Detailed information for compound 1632789

Basic information

Technical information
  • TDR Targets ID: 1632789
  • Name: 1-ethyl-4-phenylazepane-4-carbonitrile
  • MW: 228.333 | Formula: C15H20N2
  • H donors: 0 H acceptors: 1 LogP: 2.68 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCCC(CC1)(C#N)c1ccccc1
  • InChi: 1S/C15H20N2/c1-2-17-11-6-9-15(13-16,10-12-17)14-7-4-3-5-8-14/h3-5,7-8H,2,6,9-12H2,1H3
  • InChiKey: VGTIIMMLFBZHTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-ethyl-4-phenyl-azepane-4-carbonitrile
  • 1-Ethyl-4-phenyl-4-azepanecarbonitrile
  • AIDS-130246
  • AIDS130246
  • NCI60_003740
  • NSC 400476

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1357 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0719 0.0937 0.0937
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Leishmania major phosphatidylinositol kinase related protein, putative 0.0467 0.0577 0.0431
Giardia lamblia GTOR 0.7081 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0467 0.0577 0.0573
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0526 0.0661 0.0609
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.001 0.0006
Trypanosoma brucei sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0654 0.0844 0.0793
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0063 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0467 0.0577 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1045 0.14 0.14
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0154 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.4232 0.5941 0.5919
Echinococcus granulosus Solute carrier family 22 5 0.1035 0.1386 0.1386
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0486 0.0604 0.0603
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0169 0.0152 0.2507
Giardia lamblia Sugar-proton symporter 0.022 0.0225 0.0224
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0654 0.0844 0.0843
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0526 0.0661 0.0609
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.4206 0.5904 0.5881
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.9541
Trichomonas vaginalis PIKK family atypical protein kinase 0.3837 0.5378 0.5352
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0467 0.0577 0.0525
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0825 0.1086 0.1086
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0615 0.0788 0.0787
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni immunophilin 0.0146 0.0119 0.0115
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2452 0.3405 0.3405
Leishmania major phosphatidylinositol 3-kinase, putative 0.2402 0.3334 0.3231
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.1357 0.1845 0.18
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0224 0.0231 0.0227
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0554 0.0701 0.07
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0467 0.0577 0.0719
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Mycobacterium ulcerans integral membrane transport protein 0.022 0.0225 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0169 0.0152 0.0148
Leishmania major glucose transporter/membrane transporter D2, putative 0.022 0.0225 0.0074
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1512 0.2065 0.2735
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Plasmodium vivax hypothetical protein 0.0467 0.0577 0.9541
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0169 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.1045 0.14 0.1397
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0152 0.0151
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7081 1 1
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Entamoeba histolytica protein kinase rad3, putative 0.1357 0.1845 0.1845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2452 0.3405 0.3402
Loa Loa (eye worm) phosphatidylinositol kinase 0.0467 0.0577 0.0573
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.022 0.0225 0.0171
Toxoplasma gondii FATC domain-containing protein 0.1357 0.1845 0.2437
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0825 0.1086 0.1086
Loa Loa (eye worm) hypothetical protein 0.1435 0.1955 0.1952
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.089 0.118 0.1179
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0467 0.0577 0.0573
Plasmodium vivax hexose transporter 0.022 0.0225 0.3707
Entamoeba histolytica hypothetical protein 0.0615 0.0788 0.0787
Toxoplasma gondii sugar transporter ST2 0.022 0.0225 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.1901 0.2621 0.258
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0209 0.021 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.4206 0.5904 0.5881
Loa Loa (eye worm) hypothetical protein 0.0146 0.0119 0.0115
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.022 0.0225 1
Brugia malayi hypothetical protein 0.022 0.0225 0.0221
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Echinococcus multilocularis rac serine:threonine kinase 0.0069 0.001 0.001
Brugia malayi Major Facilitator Superfamily protein 0.022 0.0225 0.0221
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0526 0.0661 0.0609
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0169 0.0152 0.0151
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0013 0.0009
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Echinococcus multilocularis fk506 binding protein 0.0169 0.0152 0.0152
Schistosoma mansoni glucose transport protein 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.1357 0.1845 0.18
Plasmodium vivax sugar transporter, putative 0.022 0.0225 0.3707
Brugia malayi p70 ribosomal S6 kinase beta 0.0094 0.0046 0.0042
Entamoeba histolytica hypothetical protein 0.0467 0.0577 0.0576
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0654 0.0844 0.0843
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis fk506-binding protein, putative 0.0169 0.0152 0.0098
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7081 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0603
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2413 0.3349 0.3246
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0486 0.0604 0.0756
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0169 0.0152 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.6036 0.8511 0.8503
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0486 0.0604 0.0552
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0486 0.0604 0.0756
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0486 0.0604 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1045 0.14 0.14
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0209 0.021 0.0156
Onchocerca volvulus 0.0467 0.0577 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.1357 0.1845 0.1842
Schistosoma mansoni glucose transporter 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Toxoplasma gondii target of rapamycin (TOR), putative 0.5277 0.743 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0825 0.1086 0.1083
Echinococcus granulosus serine threonine protein kinase nrc 0.0063 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0486 0.0604 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Brugia malayi Major Facilitator Superfamily protein 0.022 0.0225 0.0221
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0152 0.0151
Toxoplasma gondii transporter, major facilitator family protein 0.022 0.0225 0.0242
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0169 0.0152 0.5
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0069 0.001 0.0009
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.022 0.0225 0.0225
Echinococcus multilocularis 0.0467 0.0577 0.0577
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0719 0.0937 0.0937
Schistosoma mansoni voltage-gated potassium channel 0.0244 0.026 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.7081 1 1
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Entamoeba histolytica hypothetical protein 0.0467 0.0577 0.0576
Loa Loa (eye worm) hypothetical protein 0.089 0.118 0.1177
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0152 0.0152
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi hexose transporter 0.022 0.0225 0.0224
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0467 0.0577 0.0719
Schistosoma mansoni hypothetical protein 0.022 0.0225 0.0221
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2402 0.3334 0.3297
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0467 0.0577 0.0576
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1357 0.1845 0.1842
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0169 0.0152 0.0148
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0526 0.0661 0.0609
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0169 0.0152 0.0151
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7081 1 1
Trypanosoma brucei glucose transporter 2A 0.022 0.0225 0.0171
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.0604 0.0552
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2952 0.4117 0.4085
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0467 0.0577 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0486 0.0604 1
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Brugia malayi major facilitator superfamily protein 0.022 0.0225 0.0221
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0188 0.0179 0.0178
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis glucose transporter, putative 0.022 0.0225 0.0171
Onchocerca volvulus 0.0467 0.0577 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.022 0.0225 0.0171
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.001 0.0009
Entamoeba histolytica protein kinase, putative 0.0101 0.0055 0.0054
Entamoeba histolytica protein kinase, putative 0.0101 0.0055 0.0054
Brugia malayi major facilitator superfamily protein 0.022 0.0225 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.089 0.118 0.1132
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Toxoplasma gondii facilitative glucose transporter GT1 0.022 0.0225 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.7081 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0603
Leishmania major glucose transporter, lmgt1 0.022 0.0225 0.0074
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0486 0.0604 0.0601
Loa Loa (eye worm) phosphatidylinositol 3 0.7081 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1357 0.1845 0.18
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0506 0.0633 0.0632
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2452 0.3405 0.3402
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0467 0.0577 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.4232 0.5941 0.5919
Trichomonas vaginalis PIKK family atypical protein kinase 0.3837 0.5378 0.5352
Echinococcus granulosus Sugar transporter ERD6 protein 0.022 0.0225 0.0225
Brugia malayi Sugar transporter family protein 0.022 0.0225 0.0221
Leishmania major glucose transporter, lmgt2 0.022 0.0225 0.0074
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Mycobacterium ulcerans sugar transporter 0.022 0.0225 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5646 0.7956 0.7925
Loa Loa (eye worm) FKBP5 protein 0.0169 0.0152 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.089 0.118 0.1132
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1357 0.1845 0.1842
Plasmodium falciparum hexose transporter 0.022 0.0225 0.3707
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.001 0.0009
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.9541
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.0604 0.0552
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0547 0.0691 0.069
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0586 0.0747 0.0747
Trichomonas vaginalis PIKK family atypical protein kinase 0.7081 1 1
Schistosoma mansoni glucose transport protein 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis myo-inositol transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7081 1 1
Leishmania major myo-inositol/proton symporter (MIT) 0.022 0.0225 0.0074
Brugia malayi hypothetical protein 0.022 0.0225 0.0221
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0169 0.0152 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Trypanosoma cruzi target of rapamycin kinase 3 0.5646 0.7956 0.7956
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0577 0.0573
Trypanosoma cruzi sugar transporter, putative 0.022 0.0225 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.0039 0.0038
Loa Loa (eye worm) sugar transporter 0.022 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1357 0.1845 0.1845
Loa Loa (eye worm) hypothetical protein 0.0068 0.0009 0.0005
Schistosoma mansoni immunophilin 0.0169 0.0152 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Brugia malayi Cytochrome P450 family protein 0.0071 0.0013 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0467 0.0577 0.5
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0467 0.0577 0.9541
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0459
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0654 0.0844 0.0793
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1357 0.1845 0.1845
Leishmania major phosphatidylinositol kinase, putative 0.0467 0.0577 0.0431
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1357 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Leishmania major phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0431
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0486 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5646 0.7956 0.7945
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.022 0.0225 0.5
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0224 0.0231 0.0231
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0065 0.0004 0.0004
Trypanosoma brucei glucose transporter 1E 0.022 0.0225 0.0171
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0224 0.0231 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.4232 0.5941 0.5919
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2452 0.3405 0.3404
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0526 0.0661 0.066
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0169 0.0152 0.2507
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.001 0.0006
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7081 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0526 0.0661 0.066
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0594 0.0758 0.0707
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis glucose transporter, putative 0.022 0.0225 0.0171
Echinococcus granulosus voltage gated potassium channel 0.0065 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Entamoeba histolytica protein kinase, putative 0.0094 0.0046 0.0045
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7081 1 1
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0486 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0586 0.0747 0.0743
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2452 0.3405 0.3404
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.0119 0.0119
Trichomonas vaginalis sugar transport protein, putative 0.022 0.0225 0.0171
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2452 0.3405 0.3405
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0467 0.0577 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Schistosoma mansoni voltage-gated potassium channel 0.0244 0.026 0.0256
Giardia lamblia Hypothetical protein 0.0467 0.0577 0.0576
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0486 0.0604 0.0601
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.4596 0.6459 0.644
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Brugia malayi Sugar transporter family protein 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0152 0.0151
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0486 0.0604 0.0601
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0525
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0169 0.0152 0.0152
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7081 1 1
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) AGC/AKT protein kinase 0.0101 0.0055 0.0051
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0094 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0194 0.0188 0.0184
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0526 0.0661 0.0657
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2413 0.3349 0.3312
Loa Loa (eye worm) sugar transporter 0.022 0.0225 0.0221
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7081 1 1
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0486 0.0604 0.0604
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3342 0.4673 0.4643
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.0119 0.0119
Loa Loa (eye worm) major facilitator superfamily transporter 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0586 0.0747 0.0747
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) major facilitator superfamily transporter 0.022 0.0225 0.0221
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0065 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.2413 0.3349 0.3312
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.022 0.0225 1
Entamoeba histolytica hypothetical protein 0.1357 0.1845 0.1845
Schistosoma mansoni glucose transport protein 0.022 0.0225 0.0221
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0526 0.0661 0.066
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Plasmodium vivax hypothetical protein, conserved 0.0467 0.0577 0.9541
Giardia lamblia Phosphatidylinositol 4-kinase 0.0467 0.0577 0.0576
Echinococcus granulosus serine protein kinase ATM 0.1357 0.1845 0.1845
Echinococcus granulosus serine/threonine protein kinase 0.0069 0.001 0.001
Trichomonas vaginalis glucose transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis Zinc finger, PHD finger 0.0486 0.0604 0.0604
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7081 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0577 0.0525
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0526 0.0661 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1357 0.1845 0.1842
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.022 0.0225 0.3707
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Loa Loa (eye worm) phosphatidylinositol 3 0.0785 0.103 0.1027
Leishmania major phosphatidylinositol 3-kinase, putative 0.0486 0.0604 0.0459
Trypanosoma cruzi Protein kinase B 0.0069 0.001 0.0009
Schistosoma mansoni fkbp-rapamycin associated protein 0.1357 0.1845 0.1842
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0586 0.0747 0.0743
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Leishmania major hypothetical protein, conserved 0.0556 0.0704 0.0561
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0152 0.0098
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Brugia malayi Sugar transporter family protein 0.022 0.0225 0.0221
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0467 0.0577 0.9541
Trichomonas vaginalis PIKK family atypical protein kinase 0.3837 0.5378 0.5352
Echinococcus multilocularis voltage gated potassium channel 0.0065 0.0004 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei THT1 - hexose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0577 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Trypanosoma brucei THT1 - hexose transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis serine protein kinase ATM 0.1357 0.1845 0.1845
Leishmania major hypothetical protein, conserved 0.022 0.0225 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.2413 0.3349 0.3346
Entamoeba histolytica hypothetical protein 0.0467 0.0577 0.0576
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0152 0.0098
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0594 0.0758 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.186 0.1816
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0169 0.0152 0.0151
Brugia malayi Protein kinase domain containing protein 0.0101 0.0055 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.1045 0.14 0.1353
Echinococcus granulosus synaptic vesicle 2 protein 0.022 0.0225 0.0225
Brugia malayi hypothetical protein 0.022 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Toxoplasma gondii sugar transporter ST1 0.022 0.0225 0.0242
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi glucose transporter, putative 0.022 0.0225 0.0224
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0063 0.0001 0.0001
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0467 0.0577 0.0525
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0486 0.0604 0.0603
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0552
Toxoplasma gondii sugar transporter ST3 0.022 0.0225 0.0242
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0467 0.0577 0.0576
Trichomonas vaginalis immunophilin, putative 0.0169 0.0152 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0467 0.0577 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0467 0.0577 0.9541
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.0467 0.0577 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0152 0.0098
Schistosoma mansoni immunophilin 0.0169 0.0152 0.0148
Echinococcus multilocularis synaptic vesicle 2 protein 0.022 0.0225 0.0225
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7081 1 1
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.1512 0.2065 0.2062
Leishmania major glucose transporter, lmgt3 0.022 0.0225 0.0074
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0654 0.0844 0.0843
Mycobacterium tuberculosis Conserved hypothetical protein 0.0467 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0654 0.0844 0.0793
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0467 0.0577 0.0573
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Giardia lamblia Hexose transporter 0.022 0.0225 0.0224
Echinococcus multilocularis Sugar transporter ERD6 protein 0.022 0.0225 0.0225
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7081 1 1
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.1512 0.2065 0.2022
Brugia malayi Major Facilitator Superfamily protein 0.022 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0576
Schistosoma mansoni hypothetical protein 0.1045 0.14 0.1397
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0577 0.0573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0654 0.0844 0.084
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0467 0.0577 0.0719
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1368 0.186 0.186
Brugia malayi FAT domain containing protein 0.1045 0.14 0.1397
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0152 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0577 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.475 0.6679 0.6661
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0224 0.0231 0.0231
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0152 0.0098
Leishmania major hypothetical protein, unknown function 0.0467 0.0577 0.0431

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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