Detailed information for compound 1635341

Basic information

Technical information
  • TDR Targets ID: 1635341
  • Name: 1,1-dimethyl-4-phenylazepan-1-ium-4-carbonitr ile
  • MW: 229.341 | Formula: C15H21N2+
  • H donors: 0 H acceptors: 1 LogP: 2.33 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CCC[N+](CC1)(C)C)c1ccccc1
  • InChi: 1S/C15H21N2/c1-17(2)11-6-9-15(13-16,10-12-17)14-7-4-3-5-8-14/h3-5,7-8H,6,9-12H2,1-2H3/q+1
  • InChiKey: YWGSRELTNDVXPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,1-dimethyl-4-phenyl-azepan-1-ium-4-carbonitrile
  • 1,1-dimethyl-4-phenyl-4-azepan-1-iumcarbonitrile
  • NCI60_003742
  • 1,1-Dimethyl-4-phenyl-1.lambda.~5~-azepane-4-carbonitrile
  • AIDS-130248
  • AIDS130248
  • 1,1-Dimethyl-4-phenyl-1lambda(5)-azepane-4-carbonitrile
  • NSC 400480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Sugar transporter family protein 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.3837 0.5378 0.5352
Echinococcus granulosus Sugar transporter ERD6 protein 0.022 0.0225 0.0225
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0467 0.0577 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.4232 0.5941 0.5919
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1357 0.1845 0.18
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0506 0.0633 0.0632
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2452 0.3405 0.3402
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0486 0.0604 0.0601
Loa Loa (eye worm) phosphatidylinositol 3 0.7081 1 1
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Leishmania major glucose transporter, lmgt1 0.022 0.0225 0.0074
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.001 0.0009
Plasmodium falciparum hexose transporter 0.022 0.0225 0.3707
Trichomonas vaginalis PIKK family atypical protein kinase 0.089 0.118 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0576
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1357 0.1845 0.1842
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5646 0.7956 0.7925
Loa Loa (eye worm) FKBP5 protein 0.0169 0.0152 0.0148
Leishmania major glucose transporter, lmgt2 0.022 0.0225 0.0074
Mycobacterium ulcerans sugar transporter 0.022 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0169 0.0152 0.0148
Brugia malayi hypothetical protein 0.022 0.0225 0.0221
Leishmania major myo-inositol/proton symporter (MIT) 0.022 0.0225 0.0074
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis myo-inositol transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7081 1 1
Schistosoma mansoni glucose transport protein 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.7081 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0547 0.0691 0.069
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.0604 0.0552
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0586 0.0747 0.0747
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.9541
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Mycobacterium leprae conserved hypothetical protein 0.0467 0.0577 0.5
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Brugia malayi Cytochrome P450 family protein 0.0071 0.0013 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Schistosoma mansoni immunophilin 0.0169 0.0152 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Loa Loa (eye worm) sugar transporter 0.022 0.0225 0.0221
Trypanosoma cruzi sugar transporter, putative 0.022 0.0225 0.0224
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1357 0.1845 0.1845
Loa Loa (eye worm) hypothetical protein 0.0068 0.0009 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0577 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Trypanosoma cruzi target of rapamycin kinase 3 0.5646 0.7956 0.7956
Echinococcus multilocularis 0.0467 0.0577 0.0577
Schistosoma mansoni voltage-gated potassium channel 0.0244 0.026 0.0256
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0719 0.0937 0.0937
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0069 0.001 0.0009
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.022 0.0225 0.0225
Toxoplasma gondii transporter, major facilitator family protein 0.022 0.0225 0.0242
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0169 0.0152 0.5
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0152 0.0151
Brugia malayi Major Facilitator Superfamily protein 0.022 0.0225 0.0221
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0486 0.0604 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0169 0.0152 0.0148
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0467 0.0577 0.0576
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1357 0.1845 0.1842
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0467 0.0577 0.0719
Schistosoma mansoni hypothetical protein 0.022 0.0225 0.0221
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2402 0.3334 0.3297
Trypanosoma cruzi hexose transporter 0.022 0.0225 0.0224
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.089 0.118 0.1177
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0152 0.0152
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Entamoeba histolytica hypothetical protein 0.0467 0.0577 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.7081 1 1
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0486 0.0604 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2952 0.4117 0.4085
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0467 0.0577 0.0576
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.0604 0.0552
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei glucose transporter 2A 0.022 0.0225 0.0171
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7081 1 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0169 0.0152 0.0151
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0526 0.0661 0.0609
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Toxoplasma gondii facilitative glucose transporter GT1 0.022 0.0225 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.7081 1 1
Brugia malayi major facilitator superfamily protein 0.022 0.0225 0.0221
Entamoeba histolytica protein kinase, putative 0.0101 0.0055 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.089 0.118 0.1132
Trypanosoma brucei THT1 - hexose transporter, putative 0.022 0.0225 0.0171
Onchocerca volvulus 0.0467 0.0577 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.001 0.0009
Entamoeba histolytica protein kinase, putative 0.0101 0.0055 0.0054
Trichomonas vaginalis glucose transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Brugia malayi major facilitator superfamily protein 0.022 0.0225 0.0221
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0188 0.0179 0.0178
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.022 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Brugia malayi hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.4206 0.5904 0.5881
Loa Loa (eye worm) hypothetical protein 0.0146 0.0119 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.1901 0.2621 0.258
Toxoplasma gondii sugar transporter ST2 0.022 0.0225 0.0242
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0209 0.021 0.0156
Entamoeba histolytica hypothetical protein 0.0615 0.0788 0.0787
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0467 0.0577 0.0573
Plasmodium vivax hexose transporter 0.022 0.0225 0.3707
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.089 0.118 0.1179
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.1435 0.1955 0.1952
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0825 0.1086 0.1086
Plasmodium vivax sugar transporter, putative 0.022 0.0225 0.3707
Schistosoma mansoni glucose transport protein 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.1357 0.1845 0.18
Echinococcus multilocularis fk506 binding protein 0.0169 0.0152 0.0152
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0013 0.0009
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0169 0.0152 0.0151
Echinococcus multilocularis rac serine:threonine kinase 0.0069 0.001 0.001
Brugia malayi Major Facilitator Superfamily protein 0.022 0.0225 0.0221
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0526 0.0661 0.0609
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0486 0.0604 0.0756
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0486 0.0604 0.0552
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0169 0.0152 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.6036 0.8511 0.8503
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2413 0.3349 0.3246
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0486 0.0604 0.0756
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7081 1 1
Trichomonas vaginalis fk506-binding protein, putative 0.0169 0.0152 0.0098
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0603
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0654 0.0844 0.0843
Entamoeba histolytica hypothetical protein 0.0467 0.0577 0.0576
Brugia malayi p70 ribosomal S6 kinase beta 0.0094 0.0046 0.0042
Echinococcus granulosus serine threonine protein kinase nrc 0.0063 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Toxoplasma gondii target of rapamycin (TOR), putative 0.5277 0.743 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0825 0.1086 0.1083
Loa Loa (eye worm) hypothetical protein 0.1357 0.1845 0.1842
Schistosoma mansoni glucose transporter 0.022 0.0225 0.0221
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0152 0.0152
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1045 0.14 0.14
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0209 0.021 0.0156
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0486 0.0604 1
Onchocerca volvulus 0.0467 0.0577 1
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0063 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Schistosoma mansoni hypothetical protein 0.0467 0.0577 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.001 0.0006
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0526 0.0661 0.0609
Trypanosoma brucei sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0654 0.0844 0.0793
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0467 0.0577 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Leishmania major phosphatidylinositol kinase related protein, putative 0.0467 0.0577 0.0431
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Giardia lamblia GTOR 0.7081 1 1
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0719 0.0937 0.0937
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1357 0.1845 0.1845
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0615 0.0788 0.0787
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0825 0.1086 0.1086
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.3837 0.5378 0.5352
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0467 0.0577 0.0525
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.9541
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.4206 0.5904 0.5881
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0526 0.0661 0.0609
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0654 0.0844 0.0843
Giardia lamblia Sugar-proton symporter 0.022 0.0225 0.0224
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.022 0.0225 0.0221
Echinococcus granulosus Solute carrier family 22 5 0.1035 0.1386 0.1386
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0486 0.0604 0.0603
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0169 0.0152 0.2507
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0154 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.4232 0.5941 0.5919
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1045 0.14 0.14
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1512 0.2065 0.2735
Mycobacterium ulcerans integral membrane transport protein 0.022 0.0225 1
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0169 0.0152 0.0148
Leishmania major glucose transporter/membrane transporter D2, putative 0.022 0.0225 0.0074
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0224 0.0231 0.0227
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0554 0.0701 0.07
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0467 0.0577 0.0719
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.1357 0.1845 0.18
Leishmania major phosphatidylinositol 3-kinase, putative 0.2402 0.3334 0.3231
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Schistosoma mansoni immunophilin 0.0146 0.0119 0.0115
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2452 0.3405 0.3405
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.022 0.0225 0.0171
Toxoplasma gondii FATC domain-containing protein 0.1357 0.1845 0.2437
Loa Loa (eye worm) phosphatidylinositol kinase 0.0467 0.0577 0.0573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2452 0.3405 0.3402
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Entamoeba histolytica protein kinase rad3, putative 0.1357 0.1845 0.1845
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7081 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0152 0.0151
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0169 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.1045 0.14 0.1397
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Plasmodium vivax hypothetical protein 0.0467 0.0577 0.9541
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Loa Loa (eye worm) hypothetical protein 0.0467 0.0577 0.0573
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0467 0.0577 0.9541
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0467 0.0577 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Trichomonas vaginalis immunophilin, putative 0.0169 0.0152 0.0098
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0552
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0486 0.0604 0.0603
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0467 0.0577 0.0576
Toxoplasma gondii sugar transporter ST3 0.022 0.0225 0.0242
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0467 0.0577 0.0573
Echinococcus multilocularis solute carrier family 22 0.022 0.0225 0.0225
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0654 0.0844 0.0793
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Leishmania major glucose transporter, lmgt3 0.022 0.0225 0.0074
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Mycobacterium tuberculosis Conserved hypothetical protein 0.0467 0.0577 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0654 0.0844 0.0843
Loa Loa (eye worm) hypothetical protein 0.1512 0.2065 0.2062
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7081 1 1
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni immunophilin 0.0169 0.0152 0.0148
Echinococcus multilocularis synaptic vesicle 2 protein 0.022 0.0225 0.0225
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0152 0.0098
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1368 0.186 0.186
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0654 0.0844 0.084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0577 0.0573
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0467 0.0577 0.0719
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0576
Schistosoma mansoni hypothetical protein 0.1045 0.14 0.1397
Brugia malayi Major Facilitator Superfamily protein 0.022 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.1512 0.2065 0.2022
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7081 1 1
Giardia lamblia Hexose transporter 0.022 0.0225 0.0224
Echinococcus multilocularis Sugar transporter ERD6 protein 0.022 0.0225 0.0225
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Leishmania major hypothetical protein, unknown function 0.0467 0.0577 0.0431
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0152 0.0098
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0224 0.0231 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.475 0.6679 0.6661
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0577 0.0525
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0152 0.0151
Brugia malayi FAT domain containing protein 0.1045 0.14 0.1397
Leishmania major hypothetical protein, conserved 0.0556 0.0704 0.0561
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0152 0.0098
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0586 0.0747 0.0743
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni fkbp-rapamycin associated protein 0.1357 0.1845 0.1842
Trypanosoma cruzi Protein kinase B 0.0069 0.001 0.0009
Leishmania major phosphatidylinositol 3-kinase, putative 0.0486 0.0604 0.0459
Loa Loa (eye worm) phosphatidylinositol 3 0.0785 0.103 0.1027
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.022 0.0225 0.3707
Trypanosoma cruzi hexose transporter, putative 0.022 0.0225 0.0224
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1357 0.1845 0.1842
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.743 0.7416
Echinococcus multilocularis serine protein kinase ATM 0.1357 0.1845 0.1845
Leishmania major hypothetical protein, conserved 0.022 0.0225 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.2413 0.3349 0.3346
Trypanosoma brucei THT1 - hexose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0467 0.0577 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Trypanosoma brucei THT1 - hexose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.3837 0.5378 0.5352
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0467 0.0577 0.9541
Brugia malayi Sugar transporter family protein 0.022 0.0225 0.0221
Echinococcus multilocularis voltage gated potassium channel 0.0065 0.0004 0.0004
Brugia malayi hypothetical protein 0.022 0.0225 0.0221
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0169 0.0152 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.186 0.1816
Echinococcus granulosus synaptic vesicle 2 protein 0.022 0.0225 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.1045 0.14 0.1353
Brugia malayi Protein kinase domain containing protein 0.0101 0.0055 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0594 0.0758 0.0707
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0152 0.0098
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni sugar transporter 0.022 0.0225 0.0221
Entamoeba histolytica hypothetical protein 0.0467 0.0577 0.0576
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0467 0.0577 0.0525
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi glucose transporter, putative 0.022 0.0225 0.0224
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0063 0.0001 0.0001
Toxoplasma gondii sugar transporter ST1 0.022 0.0225 0.0242
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0525
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0152 0.0151
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0486 0.0604 0.0601
Brugia malayi Sugar transporter family protein 0.022 0.0225 0.0221
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Giardia lamblia Hypothetical protein 0.0467 0.0577 0.0576
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0486 0.0604 0.0601
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Schistosoma mansoni voltage-gated potassium channel 0.0244 0.026 0.0256
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.4596 0.6459 0.644
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7081 1 1
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) sugar transporter 0.022 0.0225 0.0221
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0526 0.0661 0.0657
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2413 0.3349 0.3312
Loa Loa (eye worm) hypothetical protein 0.0194 0.0188 0.0184
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0094 0.0046 0.0042
Loa Loa (eye worm) AGC/AKT protein kinase 0.0101 0.0055 0.0051
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7081 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0169 0.0152 0.0152
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) major facilitator superfamily transporter 0.022 0.0225 0.0221
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0065 0.0004 0.0004
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0586 0.0747 0.0747
Loa Loa (eye worm) major facilitator superfamily transporter 0.022 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.0119 0.0119
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0486 0.0604 0.0604
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3342 0.4673 0.4643
Echinococcus multilocularis Zinc finger, PHD finger 0.0486 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0577 0.0525
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0526 0.0661 0.0657
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7081 1 1
Trichomonas vaginalis glucose transporter, putative 0.022 0.0225 0.0171
Echinococcus granulosus serine/threonine protein kinase 0.0069 0.001 0.001
Giardia lamblia Phosphatidylinositol 4-kinase 0.0467 0.0577 0.0576
Echinococcus granulosus serine protein kinase ATM 0.1357 0.1845 0.1845
Plasmodium vivax hypothetical protein, conserved 0.0467 0.0577 0.9541
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0526 0.0661 0.066
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5386 0.5361
Entamoeba histolytica hypothetical protein 0.1357 0.1845 0.1845
Schistosoma mansoni glucose transport protein 0.022 0.0225 0.0221
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.2413 0.3349 0.3312
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.022 0.0225 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Leishmania major phosphatidylinositol 4-kinase, putative 0.0467 0.0577 0.0431
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1357 0.1845 0.1845
Leishmania major phosphatidylinositol kinase, putative 0.0467 0.0577 0.0431
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1357 0.1845 0.1845
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0654 0.0844 0.0793
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0486 0.0604 0.0459
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0467 0.0577 0.9541
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Trypanosoma brucei glucose transporter 1E 0.022 0.0225 0.0171
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0065 0.0004 0.0004
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0224 0.0231 0.0231
Loa Loa (eye worm) phosphatidylinositol 3 0.0467 0.0577 0.0573
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.022 0.0225 0.5
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5646 0.7956 0.7945
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Loa Loa (eye worm) hypothetical protein 0.022 0.0225 0.0221
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0486 0.0604 0.0604
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7081 1 1
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0467 0.0577 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0225 0.0171
Echinococcus granulosus voltage gated potassium channel 0.0065 0.0004 0.0004
Entamoeba histolytica protein kinase, putative 0.0094 0.0046 0.0045
Trypanosoma brucei glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis glucose transporter, putative 0.022 0.0225 0.0171
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0594 0.0758 0.0707
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0169 0.0152 0.2507
Echinococcus granulosus solute carrier family 22 0.022 0.0225 0.0225
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.001 0.0006
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0526 0.0661 0.066
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7081 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0526 0.0661 0.066
Trichomonas vaginalis PIKK family atypical protein kinase 0.4232 0.5941 0.5919
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2452 0.3405 0.3404
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0224 0.0231 0.0227
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0467 0.0577 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.564 0.7948 0.7937
Trichomonas vaginalis PIKK family atypical protein kinase 0.2402 0.3334 0.3297
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2452 0.3405 0.3405
Trichomonas vaginalis sugar transport protein, putative 0.022 0.0225 0.0171
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.0119 0.0119
Trichomonas vaginalis sugar transporter, putative 0.022 0.0225 0.0171
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0486 0.0604 0.0604
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.0225 0.0225
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2452 0.3405 0.3404
Loa Loa (eye worm) hypothetical protein 0.0586 0.0747 0.0743

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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