TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.119 | Formula: C18H15Br2N2NaO6
H donors: 3 H acceptors: 6 LogP: 0.43 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: [O-]C(=O)CN(Cc1cc(/N=C/2\C=C(Br)C(=O)C(=C2)Br)cc(c1O)C)CC(=O)O.[Na+]
InChi: 1S/C18H16Br2N2O6.Na/c1-9-2-11(21-12-4-13(19)18(28)14(20)5-12)3-10(17(9)27)6-22(7-15(23)24)8-16(25)26;/h2-5,27H,6-8H2,1H3,(H,23,24)(H,25,26);/q;+1/p-1
InChiKey: CWYYETRODOOCRC-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0561	0.2083	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0057	0.0183	0.1955
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.001	0.001
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0172	0.0616	0.0543
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0172	0.0616	0.0543
Brugia malayi	RNA binding protein	0.0074	0.0246	0.0243
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0057	0.0183	0.018
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.0185	0.0108
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0057	0.0183	0.0183
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0503	0.1866	0.1803
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0892	0.3333	0.3333
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0246	0.0243
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0892	0.3333	0.3281
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.001	0.001
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0503	0.1866	0.1803
Leishmania major	hypothetical protein, unknown function	0.0172	0.0616	0.0543
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0892	0.3333	0.3333
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0246	0.0246
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0503	0.1866	0.1864
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0003	0.0003
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.2661	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Echinococcus multilocularis	smad	0.0009	0.0003	0.0003
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0389	0.1436	0.1436
Schistosoma mansoni	cpg binding protein	0.0035	0.0101	0.0101
Leishmania major	hypothetical protein, conserved	0.0172	0.0616	0.0543
Schistosoma mansoni	immunophilin	0.0057	0.0183	0.0183
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0172	0.0616	0.0613
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0246	0.0246
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Echinococcus granulosus	geminin	0.0197	0.0711	0.0711
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0057	0.0183	0.0183
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0172	0.0616	0.0613
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0246	0.0246
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1979	0.743	0.7409
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.001	0.001
Giardia lamblia	GTOR	0.2661	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.001	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1437	0.5385	0.5349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0332	0.1219	0.115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.1866	0.1803
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0172	0.0616	0.0543
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0334	0.123	0.1161
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0246	0.0246
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1435	0.5377	0.5341
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0172	0.0616	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.0467	0.0465
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1574	0.5903	0.5871
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0172	0.0616	0.0543
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0172	0.0616	0.0616
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0197	0.0711	0.0711
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.001	0.0007
Loa Loa (eye worm)	flap endonuclease-1	0.0029	0.0078	0.0075
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0172	0.0616	0.0543
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0389	0.1436	0.1436
Schistosoma mansoni	hypothetical protein	0.047	0.1741	0.1741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.159	0.5963	0.5931
Echinococcus granulosus	smad	0.0009	0.0003	0.0003
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.0467	0.0465
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.001	0.0007
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0172	0.0616	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	0.0543
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0172	0.0616	0.0616
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2272	0.8533	0.8522
Loa Loa (eye worm)	phosphatidylinositol 3	0.0892	0.3333	0.3331
Loa Loa (eye worm)	phosphatidylinositol 3	0.0172	0.0616	0.0613
Loa Loa (eye worm)	phosphatidylinositol 3	0.0172	0.0616	0.0613
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.2661	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0172	0.0616	0.0543
Schistosoma mansoni	coup transcription factor	0.0011	0.001	0.001
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0176	0.0633	1
Giardia lamblia	Hypothetical protein	0.0172	0.0616	0.0543
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0334	0.123	0.1161
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1979	0.743	0.7409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1437	0.5385	0.5349
Toxoplasma gondii	FATC domain-containing protein	0.0503	0.1866	0.2433
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Echinococcus multilocularis		0.0172	0.0616	0.0616
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0503	0.1866	0.1866
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0003	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2116	0.7948	0.7931
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0172	0.0616	0.0543
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.001	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.001	0.0007
Leishmania major	phosphatidylinositol kinase, putative	0.0172	0.0616	0.0543
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0049	0.0154	0.0154
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.001	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1574	0.5903	0.5871
Schistosoma mansoni	cpg binding protein	0.0033	0.0094	0.0094
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0892	0.3333	0.3281
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0003	0.0003
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	0.0543
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0172	0.0616	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0094	0.009
Schistosoma mansoni	hypothetical protein	0.0389	0.1436	0.1436
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0057	0.0183	0.0106
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0561	0.2083	0.2728
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0334	0.123	0.1161
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0094	0.009
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0146	0.0069
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0503	0.1866	0.1864
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.001	0.001
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0067	0.0067
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.001	0.001
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0007	0.0004
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0057	0.0183	0.018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0892	0.3333	0.3281
Echinococcus multilocularis	Zinc finger, PHD finger	0.0172	0.0616	0.0616
Onchocerca volvulus		0.0172	0.0616	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1105	0.4135	0.4089
Mycobacterium leprae	conserved hypothetical protein	0.0172	0.0616	0.5
Trichomonas vaginalis	immunophilin, putative	0.0057	0.0183	0.0106
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0047	0.0146	0.0069
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.2661	1	1
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0172	0.0616	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0616	0.0613
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0892	0.3333	0.3333
Echinococcus multilocularis	flap endonuclease 1	0.0029	0.0078	0.0078
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0205	0.0173
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.2661	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.001	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1436	0.1369
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0172	0.0616	0.0543
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.001	0.001
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0246	0.0243
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.001	0.001
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0003	0.0003
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0172	0.0616	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0172	0.0616	0.0732
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.001	0.0007
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0332	0.1219	0.115
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0172	0.0616	0.0613
Echinococcus granulosus	flap endonuclease 1	0.0029	0.0078	0.0078
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.001	0.001
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0047	0.0146	0.0069
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0172	0.0616	0.0616
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	0.0543
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.001	0.001
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0503	0.1866	0.1866
Plasmodium vivax	hypothetical protein	0.0172	0.0616	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0172	0.0616	0.0543
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0172	0.0616	0.0732
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0892	0.3333	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Brugia malayi	steroid hormone receptor	0.0011	0.001	0.0007
Leishmania major	mitochondrial DNA polymerase beta	0.0334	0.123	0.1161
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0049	0.0154	0.0154
Schistosoma mansoni	cpg binding protein	0.0035	0.0101	0.0101
Onchocerca volvulus		0.0172	0.0616	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2661	1	1
Echinococcus multilocularis	Smad4	0.0009	0.0003	0.0003
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.001	0.001
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.001	0.001
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	0.0543
Brugia malayi	ecdysteroid receptor	0.0011	0.001	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.001	0.0007
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.2661	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.2661	1	1
Echinococcus multilocularis	cpg binding protein	0.0035	0.0101	0.0101
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0172	0.0616	0.0543
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.001	0.0007
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0172	0.0616	0.0616
Echinococcus multilocularis	fk506 binding protein	0.0057	0.0183	0.0183
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0172	0.0616	0.0543
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	0.0543
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.001	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1979	0.743	0.7409
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Schistosoma mansoni	immunophilin	0.0057	0.0183	0.0183
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0057	0.0183	0.0106
Echinococcus multilocularis	serine protein kinase ATM	0.0503	0.1866	0.1866
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0172	0.0616	0.0543
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0158	0.0566	0.0492
Trypanosoma cruzi	target of rapamycin kinase 3	0.2119	0.7956	0.794
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.001	0.001
Schistosoma mansoni	Smad4	0.0009	0.0003	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1435	0.5377	0.5341
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.159	0.5963	0.5931
Echinococcus granulosus	serine protein kinase ATM	0.0503	0.1866	0.1866
Entamoeba histolytica	hypothetical protein	0.0172	0.0616	0.0543
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0942	0.352	0.352
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2661	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0172	0.0616	0.0543
Loa Loa (eye worm)	phosphatidylinositol 3	0.0172	0.0616	0.0613
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.001	0.001
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.001	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.001	0.0007
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	1
Brugia malayi	nuclear hormone receptor	0.0011	0.001	0.0007
Brugia malayi	FAT domain containing protein	0.0389	0.1436	0.1433
Entamoeba histolytica	hypothetical protein	0.0503	0.1866	0.1803
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.2119	0.7956	0.794
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.001	0.001
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0057	0.0183	0.0106
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0158	0.0566	0.0492
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0246	0.0243
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0172	0.0616	0.0613
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.2661	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.001	0.001
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0057	0.0183	0.0183
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.001	0.001
Echinococcus granulosus	Smad4	0.0009	0.0003	0.0003
Entamoeba histolytica	hypothetical protein	0.0172	0.0616	0.0543
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.001	0.001
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.2661	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.159	0.5963	0.5931
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0892	0.3333	0.3281
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.001	0.0007
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2116	0.7948	0.7931
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0892	0.3333	0.3281
Toxoplasma gondii	hypothetical protein	0.0054	0.0172	0.0129
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0892	0.3333	0.3281
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0172	0.0616	0.0616
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0057	0.0183	0.0106
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0892	0.3333	0.3281
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0246	0.0246
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2116	0.7948	0.7931
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0172	0.0616	0.0732
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0503	0.1866	0.1866
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	1
Loa Loa (eye worm)	hypothetical protein	0.0503	0.1866	0.1864
Mycobacterium ulcerans	hypothetical protein	0.0176	0.0633	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0158	0.0566	0.0492
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0172	0.0616	0.0613
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0172	0.0616	0.0732
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0057	0.0183	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.001	0.001
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0172	0.0616	0.0616
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0172	0.0616	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0154	0.0151
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.2119	0.7956	0.794
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.001	0.0007
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.001	0.001
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0057	0.0183	0.0106
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0172	0.0616	0.0616
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0057	0.0183	0.0106
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.001	0.0007
Trichomonas vaginalis	fk506-binding protein, putative	0.0057	0.0183	0.0106
Entamoeba histolytica	hypothetical protein	0.0172	0.0616	0.0543
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0057	0.0183	0.1955
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2116	0.7948	0.7931
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0616	0.0613
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1258	0.4713	0.4671
Loa Loa (eye worm)	phosphatidylinositol 3	0.0172	0.0616	0.0613
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0172	0.0616	0.0616
Loa Loa (eye worm)	phosphatidylinositol 3	0.2661	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0172	0.0616	0.0543
Brugia malayi	nuclear receptor NHR-88	0.0011	0.001	0.0007
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0172	0.0616	0.0543
Entamoeba histolytica	protein kinase rad3, putative	0.0503	0.1866	0.1803
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0172	0.0616	0.0616
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1437	0.5385	0.5349
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0172	0.0616	0.0616
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0503	0.1866	0.1803
Echinococcus granulosus	cpg binding protein	0.0035	0.0101	0.0101
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0172	0.0616	0.0616
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0892	0.3333	0.3281
Leishmania major	peptidylprolyl isomerase-like protein	0.0057	0.0183	0.0106
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0172	0.0616	0.0543
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0172	0.0616	0.0616
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0057	0.0183	0.0183
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.001	0.0007
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0892	0.3333	0.3281
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0172	0.0616	0.0613
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0172	0.0616	0.0543
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.0233	0.0233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0172	0.0616	0.0543
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1727	0.6481	0.6453
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.2661	1	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0057	0.0183	0.0106
Leishmania major	fk506-binding protein 1-like protein	0.0057	0.0183	0.0106
Entamoeba histolytica	hypothetical protein	0.0172	0.0616	0.0543
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0892	0.3333	0.3281
Schistosoma mansoni	smad	0.0009	0.0003	0.0003
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0057	0.0183	0.0106
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.2661	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.001	0.0007
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.001	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0542	0.2013	0.2011
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0389	0.1436	0.1433
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0172	0.0616	0.0616
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0008	0.0008
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0246	0.0243
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0057	0.0183	0.018
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.001	0.001
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0172	0.0616	0.0543
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0057	0.0183	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0007
Onchocerca volvulus		0.0033	0.0094	0.1377
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0246	0.0246
Schistosoma mansoni	immunophilin	0.0049	0.0154	0.0154
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Loa Loa (eye worm)	FKBP5 protein	0.0057	0.0183	0.018
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0003	0.0003
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0172	0.0616	0.0616
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.1866	0.1803
Loa Loa (eye worm)	phosphatidylinositol 3	0.0172	0.0616	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0332	0.1219	0.1216
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.001	0.0007
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.001	0.001
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0503	0.1866	0.1866
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1979	0.743	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0503	0.1866	0.1803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0892	0.3333	0.3281
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.001	0.001
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.001	0.001
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2116	0.7948	0.7931
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1437	0.5385	0.5349
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0172	0.0616	0.0616
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0172	0.0616	1
Plasmodium vivax	hypothetical protein, conserved	0.0172	0.0616	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1435	0.5377	0.5341
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.001	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.1866	0.1803
Schistosoma mansoni	hypothetical protein	0.0197	0.0711	0.0711
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0172	0.0616	0.0543
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0172	0.0616	0.0732
Schistosoma mansoni	hypothetical protein	0.0172	0.0616	0.0616
Echinococcus multilocularis	dnaJ subfamily B	0.047	0.1741	0.1741
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0561	0.2083	0.2021
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0146	0.0069
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.001	0.0007
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.2661	1	1
Brugia malayi	MH2 domain containing protein	0.0132	0.0467	0.0465
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.001	0.001
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.001	0.0007
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0172	0.0616	0.0543
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0003	0.0003
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0172	0.0616	0.0543
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.001	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1979	0.743	0.7409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1785	0.6698	0.6672
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0172	0.0616	0.0543
Echinococcus granulosus	dnaJ subfamily B	0.047	0.1741	0.1741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1979	0.743	0.7409
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0172	0.0616	0.0616
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0057	0.0183	0.0106
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0172	0.0616	0.0613
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1979	0.743	0.7409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1979	0.743	0.7409
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0172	0.0616	0.0543
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.001	0.0007
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0172	0.0616	0.0616
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0172	0.0616	0.0613
Brugia malayi	Flap endonuclease-1	0.0029	0.0078	0.0075
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0172	0.0616	0.0616
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0172	0.0616	0.0613
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0246	0.0246
Echinococcus multilocularis	geminin	0.0197	0.0711	0.0711
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0057	0.0183	0.0106
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.001	0.001
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0172	0.0616	0.0616
Trichomonas vaginalis	conserved hypothetical protein	0.0332	0.1219	0.115
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0057	0.0183	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0714	0.266	0.2603
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2661	1	1
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0008	0.0005
Brugia malayi	TAR-binding protein	0.0074	0.0246	0.0243

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2028266

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1638491