Detailed information for compound 1638506

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.93 | Formula: C22H19ClN4O2S
  • H donors: 1 H acceptors: 2 LogP: 4.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c2ccccc2c2c1c(=O)n1CCSc1n2)NCCc1ccc(cc1)Cl
  • InChi: 1S/C22H19ClN4O2S/c23-15-7-5-14(6-8-15)9-10-24-18(28)13-27-17-4-2-1-3-16(17)19-20(27)21(29)26-11-12-30-22(26)25-19/h1-8H,9-13H2,(H,24,28)
  • InChiKey: OZOKYDMSYSVHFY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0215 0.0604 0.0604
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1387 0.4128 0.4128
Trichomonas vaginalis PIKK family atypical protein kinase 0.112 0.3324 0.3324
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0215 0.0604 0.0604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0112 0.0112
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0215 0.0604 0.0604
Trypanosoma brucei rac serine-threonine kinase, putative 0.0033 0.0056 0.0056
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3338 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0215 0.0604 0.0604
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0022
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0416 0.1207 0.1207
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.112 0.3324 0.3324
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0122 0.0122
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3338 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0215 0.0604 0.0604
Toxoplasma gondii AGC kinase 0.0031 0.0049 0.0067
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0022 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0053 0.0053
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0215 0.0604 0.0604
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0022 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0053 0.0053
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.027 0.027
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0604 0.0813
Entamoeba histolytica hypothetical protein 0.0215 0.0604 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0604 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0001 0.0001
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0604 0.0604
Entamoeba histolytica protein kinase, putative 0.0033 0.0056 0.0038
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0022 0.0022
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0292 0.0292
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0022 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0604 0.0604
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.112 0.3324 0.3324
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0215 0.0604 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0631 0.1855 0.1855
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0215 0.0604 0.0604
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3338 1 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0056 0.0056
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0215 0.0604 0.0604
Onchocerca volvulus 0.0279 0.0796 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0058 0.0058
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0018 0.0018
Loa Loa (eye worm) AGC/PKG protein kinase 0.0015 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0292 0.0292
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0001 0.0001
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0017 0.0017
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3338 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0022 0.0022
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0024 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0112 0.0112
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0215 0.0604 0.0604
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0604 0.0604
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0215 0.0604 0.0587
Echinococcus granulosus nervana 2 0.002 0.0017 0.0017
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0604 0.0604
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0056 0.0056
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3338 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.7426 0.7426
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0604 0.0604
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0015 0 0.5
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0122 0.0122
Trypanosoma cruzi target of rapamycin kinase 3 0.2658 0.7953 0.7953
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0604 0.0813
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0099 0.0099
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0021 0.0018 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0112 0.0112
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0631 0.1855 0.1855
Trichomonas vaginalis PIKK family atypical protein kinase 0.1995 0.5957 0.5957
Leishmania major phosphatidylinositol kinase, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.18 0.5371 0.5371
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0022 0.0022
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0022 0.0022
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.3338 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0215 0.0604 0.0604
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0022 0.0022
Echinococcus multilocularis serine protein kinase ATM 0.0631 0.1855 0.1855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.0604 0.0604
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.112 0.3324 0.3324
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0416 0.1207 0.1207
Echinococcus multilocularis nervana 2 0.002 0.0017 0.0017
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0631 0.1855 0.1841
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0009 0.0009
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0022 0.0022
Schistosoma mansoni immunophilin 0.0055 0.0122 0.0122
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0055 0.0122 0.0122
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2658 0.7953 0.7953
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0122 0.0122
Leishmania major fk506-binding protein 1-like protein 0.0055 0.0122 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0062 0.0062
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0323 0.0323
Mycobacterium leprae conserved hypothetical protein 0.0215 0.0604 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0215 0.0604 0.0604
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0062 0.0062
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0704 0.2072 0.2072
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0055 0.0122 0.0122
Loa Loa (eye worm) phosphatidylinositol 3 0.112 0.3324 0.3324
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.112 0.3324 0.3324
Trichomonas vaginalis immunophilin, putative 0.0055 0.0122 0.0122
Toxoplasma gondii FATC domain-containing protein 0.0631 0.1855 0.2498
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3338 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0122 0.0122
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0631 0.1855 0.1855
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0215 0.0604 0.0604
Leishmania major phosphatidylinositol 3-related kinase, putative 0.112 0.3324 0.3324
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0022 0.0022
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0631 0.1855 0.1855
Brugia malayi Protein kinase domain containing protein 0.0033 0.0056 0.0056
Leishmania major hypothetical protein, unknown function 0.0215 0.0604 0.0604
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0488 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0053
Leishmania major phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0604
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0587
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0215 0.0604 0.0604
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0055 0.0122 0.0122
Schistosoma mansoni immunophilin 0.0048 0.0099 0.0099
Plasmodium vivax hypothetical protein, conserved 0.0215 0.0604 1
Trichomonas vaginalis fk506-binding protein, putative 0.0055 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0631 0.1855 0.1855
Trichomonas vaginalis PIKK family atypical protein kinase 0.1803 0.5379 0.5379
Echinococcus multilocularis 0.0215 0.0604 0.0604
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0018 0.0018
Schistosoma mansoni immunophilin 0.0055 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.7426 0.7426
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0215 0.0604 0.0604
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0024 0.0024
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3338 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0215 0.0604 0.0604
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0055 0.0122 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1975 0.5898 0.5898
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.18 0.5371 0.5371
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0215 0.0604 0.0604
Giardia lamblia Phosphatidylinositol 4-kinase 0.0215 0.0604 0.0604
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.0694 0.0694
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0055 0.0122 0.2014
Trichomonas vaginalis PIKK family atypical protein kinase 0.1995 0.5957 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0488 0.1424 0.1424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.1207 0.1207
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0215 0.0604 0.0604
Giardia lamblia Kinase, AGC PKA 0.0021 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0053 0.0053
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0604 0.0604
Giardia lamblia GTOR 0.3338 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.112 0.3324 0.3324
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.285 0.8531 0.8531
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0215 0.0604 0.0604
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0122 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0604 0.0604
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0215 0.0604 0.0604
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0215 0.0604 0.0604
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0215 0.0604 0.0604
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0604
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0022 0.0022
Entamoeba histolytica protein kinase rad3, putative 0.0631 0.1855 0.1841
Trypanosoma cruzi Protein kinase B 0.0023 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.7426 0.7426
Trichomonas vaginalis set domain proteins, putative 0.0279 0.0796 0.0796
Trichomonas vaginalis PIKK family atypical protein kinase 0.1803 0.5379 0.5379
Echinococcus multilocularis nervana 2 0.002 0.0017 0.0017
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0017 0.0017
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0215 0.0604 0.0604
Schistosoma mansoni hypothetical protein 0.0488 0.1424 0.1424
Trichomonas vaginalis PIKK family atypical protein kinase 0.2655 0.7945 0.7945
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0604 0.0604
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0896 0.2651 0.2651
Trichomonas vaginalis PIKK family atypical protein kinase 0.1975 0.5898 0.5898
Brugia malayi Pre-SET motif family protein 0.0035 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0097 0.0247 0.0247
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0022 0.0022
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0055 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.068 0.2003 0.2003
Brugia malayi Pre-SET motif family protein 0.0245 0.0694 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0416 0.1207 0.1207
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0604 0.0813
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0056 0.0056
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0215 0.0604 0.0587
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0022 0.0022
Entamoeba histolytica protein kinase, putative 0.0033 0.0056 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0631 0.1855 0.1855
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0056 0.0056
Plasmodium falciparum cGMP-dependent protein kinase 0.0015 0.0001 0.0011
Echinococcus multilocularis expressed conserved protein 0.0015 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0215 0.0604 0.0604
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0053 0.0053
Leishmania major protein kinase, putative 0.0015 0.0001 0.0001
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0055 0.0122 0.0122
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0587
Echinococcus granulosus serine protein kinase ATM 0.0631 0.1855 0.1855
Leishmania major protein kinase, putative 0.0015 0.0001 0.0001
Brugia malayi FAT domain containing protein 0.0488 0.1424 0.1424
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0022 0.0022
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0215 0.0604 0.0604
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0024 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0112 0.0112
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0055 0.0122 0.0104
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0215 0.0604 0.0604
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0062 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0056 0.0056
Loa Loa (eye worm) FKBP5 protein 0.0055 0.0122 0.0122
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0022 0.0022
Schistosoma mansoni fkbp-rapamycin associated protein 0.0631 0.1855 0.1855
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0215 0.0604 0.0604
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.027 0.027
Entamoeba histolytica hypothetical protein 0.0215 0.0604 0.0587
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0055 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.7426 0.7426
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0631 0.1855 0.1855
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0022 0.0022
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0587
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0021 0.0018 0.0298
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0215 0.0604 0.0604
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0022 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0631 0.1855 0.1855
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0022 0.0022
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.112 0.3324 0.3324
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0024 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.18 0.5371 0.5371
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0215 0.0604 0.0604
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0215 0.0604 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0292 0.0292
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0024 0.0006
Plasmodium vivax hypothetical protein 0.0215 0.0604 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1803 0.5379 0.5379
Trichomonas vaginalis PIKK family atypical protein kinase 0.2655 0.7945 0.7945
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0704 0.2072 0.2791
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0056 0.0056
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0024 0.0024
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0215 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0488 0.1424 0.1424
Leishmania major hypothetical protein, conserved 0.0215 0.0604 0.0604
Mycobacterium tuberculosis Conserved hypothetical protein 0.0215 0.0604 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0215 0.0604 0.0604
Entamoeba histolytica hypothetical protein 0.0631 0.1855 0.1841
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0018 0.0018
Brugia malayi Egg laying defective protein 4 0.0015 0.0001 0.0001
Echinococcus multilocularis fk506 binding protein 0.0055 0.0122 0.0122
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3338 1 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0604 0.0604
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0488 0.1424 0.1424
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.7426 0.7426
Trichomonas vaginalis PIKK family atypical protein kinase 0.2239 0.6693 0.6693
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0604 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0001 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0292 0.0292
Toxoplasma gondii target of rapamycin (TOR), putative 0.2483 0.7426 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.0604 0.0604
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0099 0.0099
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.7426 0.7426
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0215 0.0604 0.0604
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0215 0.0604 0.0604
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0604 0.0813
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.7426 0.7426
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0215 0.0604 0.0604
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0022 0.0022
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0215 0.0604 1
Entamoeba histolytica hypothetical protein 0.0215 0.0604 0.0587
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0112 0.0112
Leishmania major peptidylprolyl isomerase-like protein 0.0055 0.0122 0.0122
Entamoeba histolytica hypothetical protein 0.0215 0.0604 0.0587
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0215 0.0604 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0122 0.0122
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0122 0.2014
Trichomonas vaginalis PIKK family atypical protein kinase 0.3338 1 1
Echinococcus granulosus cGMP dependent protein kinase 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0704 0.2072 0.2072
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0587
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0049 0.0049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0062 0.0062
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0122 0.0122
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0215 0.0604 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3338 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0049 0.0049
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.1995 0.5957 0.5957
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.112 0.3324 0.3324
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0017 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0215 0.0604 0.0587
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0001 0.0001
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0215 0.0604 0.0604
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3338 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.112 0.3324 0.3324
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2655 0.7945 0.7945
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0112 0.0112
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0604 0.0604
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.112 0.3324 0.3324
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0122 0.0122
Onchocerca volvulus 0.0215 0.0604 0.7583
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.112 0.3324 0.3324
Onchocerca volvulus 0.0035 0.0062 0.0773
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0631 0.1855 0.1855
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0631 0.1855 0.1855
Trichomonas vaginalis PIKK family atypical protein kinase 0.2655 0.7945 0.7945
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0099
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0215 0.0604 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.0604 0.0604
Echinococcus multilocularis Zinc finger, PHD finger 0.0215 0.0604 0.0604
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0055 0.0122 0.0104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0062 0.0083
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0323 0.0323
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0604 0.0813
Entamoeba histolytica protein kinase, putative 0.0031 0.0049 0.0032
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0215 0.0604 0.0604
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0112 0.0112
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0009 0.0009
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2658 0.7953 0.7953
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0022 0.0022
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0015 0.0001 0.0001
Plasmodium vivax SET domain protein, putative 0.0035 0.0062 0.1019
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1579 0.4706 0.4706
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2655 0.7945 0.7945
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0122 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0112 0.0112
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0215 0.0604 0.0604
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0604 0.0604
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0215 0.0604 0.0604
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0631 0.1855 0.1855
Echinococcus granulosus nervana 2 0.002 0.0017 0.0017
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0215 0.0604 0.0604
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0215 0.0604 0.0587
Leishmania major phosphatidylinositol 4-kinase, putative 0.0215 0.0604 0.0604
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3338 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.112 0.3324 0.3324
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0062 0.0062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0631 0.1855 0.1855
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0215 0.0604 0.0604
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0056 0.0056
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.1803 0.5379 0.5379
Giardia lamblia Hypothetical protein 0.0215 0.0604 0.0604
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0215 0.0604 0.0604
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0122 0.0122
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0215 0.0604 0.0604
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0215 0.0604 0.0604
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2167 0.6476 0.6476
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0053 0.0053
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.112 0.3324 0.3324
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0022 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0062 0.0062
Leishmania major phosphatidylinositol 3-kinase, putative 0.112 0.3324 0.3324
Onchocerca volvulus 0.0215 0.0604 0.7583
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0055 0.0122 1
Loa Loa (eye worm) phosphatidylinositol 3 0.3338 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.3338 1 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0112 0.0112

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM Antifungal activity against fluconazole-resistant Candida albicans isolate 2 assessed as growth inhibition after 48 hrs by alamar blue fluorescence assay in presence of 8 ug/ml fluconazole ChEMBL. 22497765
IC50 (functional) = 23.4 uM Antifungal activity against fluconazole-resistant Candida albicans isolate 8 assessed as growth inhibition after 48 hrs by alamar blue fluorescence assay in presence of 8 ug/ml fluconazole ChEMBL. 22497765

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Candida albicans ChEMBL23 22497765

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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