Detailed information for compound 1646309

Basic information

Technical information
  • TDR Targets ID: 1646309
  • Name: 4-amino-N'-[[3-bromo-4-[(4-chlorophenyl)metho xy]-5-ethoxyphenyl]methylideneamino]-1,2,5-ox adiazole-3-carboximidamide
  • MW: 493.742 | Formula: C19H18BrClN6O3
  • H donors: 2 H acceptors: 2 LogP: 4.2 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(/C=N/N=C(\c2nonc2N)/N)cc(c1OCc1ccc(cc1)Cl)Br
  • InChi: 1S/C19H18BrClN6O3/c1-2-28-15-8-12(9-24-25-18(22)16-19(23)27-30-26-16)7-14(20)17(15)29-10-11-3-5-13(21)6-4-11/h3-9H,2,10H2,1H3,(H2,22,25)(H2,23,27)/b24-9+
  • InChiKey: HAULVVWXOGVAOG-PGGKNCGUSA-N  


Substructure search Similarity search

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Synonyms

  • 4-amino-N'-[[3-bromo-4-[(4-chlorophenyl)methoxy]-5-ethoxy-phenyl]methyleneamino]-1,2,5-oxadiazole-3-carboxamidine
  • 4-amino-N'-[[3-bromo-4-[(4-chlorophenyl)methoxy]-5-ethoxyphenyl]methyleneamino]-1,2,5-oxadiazole-3-carboxamidine
  • 4-amino-N'-[[3-bromo-4-(4-chlorobenzyl)oxy-5-ethoxy-benzylidene]amino]furazan-3-carboxamidine
  • 4-amino-N'-[[3-bromo-4-[(4-chlorophenyl)methoxy]-5-ethoxy-phenyl]methylideneamino]-1,2,5-oxadiazole-3-carboximidamide
  • MLS000556327
  • SMR000147644
  • STOCK3S-45160

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0036 0.0318 0.0871
Trypanosoma cruzi histone deacetylase, putative 0.0115 0.1278 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0126 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0029 0.0029
Echinococcus multilocularis cysteine protease 0.002 0.0126 0.0126
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0422 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0126 0.0126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0029 0.0099
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0029 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0102 0.1124 0.3338
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2933 1
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0007 0.0025
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0422 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.0126 0.0431
Trichomonas vaginalis histone deacetylase, putative 0.0102 0.1124 0.3338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Trichomonas vaginalis histone deacetylase, putative 0.0102 0.1124 0.3338
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0126 0.0126
Toxoplasma gondii histone deacetylase HDAC3 0.0102 0.1124 0.8668
Echinococcus multilocularis histone deacetylase 1 0.0102 0.1124 0.1124
Brugia malayi Cathepsin L-like precursor 0.0014 0.0045 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Echinococcus multilocularis cathepsin L 0.001 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.025 0.2923 0.9966
Brugia malayi Cathepsin L-like precursor 0.002 0.0126 0.0431
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0816 0.6368
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0029 0.0099
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0102 0.1124 0.3338
Echinococcus multilocularis histone deacetylase 6 0.0122 0.1365 0.1365
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0029 0.0099
Echinococcus multilocularis histone deacetylase 6 0.0115 0.1278 0.1278
Echinococcus granulosus histone deacetylase 3 0.0102 0.1124 0.1124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0045 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Brugia malayi Cathepsin L-like precursor 0.002 0.0126 0.0431
Brugia malayi Histone deacetylase family protein 0.0115 0.1278 0.4357
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0029 0.0029
Plasmodium vivax histone deacetylase, putative 0.0049 0.048 0.3725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Trichomonas vaginalis AGC family protein kinase 0.025 0.2923 0.871
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0551 0.188
Schistosoma mansoni histone deacetylase hda2 0.0049 0.048 0.048
Echinococcus multilocularis histone deacetylase 6 0.0115 0.1278 0.1278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0318 0.0318
Trypanosoma cruzi histone deacetylase, putative 0.0115 0.1278 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0126 0.0126
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0735 0.5729
Schistosoma mansoni histone deacetylase 0.0102 0.1124 0.1124
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0126 0.0356
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0007 0.0025
Brugia malayi steroid hormone receptor 0.0012 0.0029 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0029 0.0029
Schistosoma mansoni inositol monophosphatase 0.0045 0.0422 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0302 0.0302
Echinococcus granulosus histone deacetylase 1 0.0102 0.1124 0.1124
Onchocerca volvulus Cathepsin F homolog 0.002 0.0126 0.0293
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.025 0.2923 0.2923
Echinococcus granulosus histone deacetylase 6 0.0115 0.1278 0.1278
Brugia malayi Inositol-1 0.0045 0.0422 0.144
Onchocerca volvulus 0.0286 0.3354 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus granulosus cathepsin L 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0154
Echinococcus granulosus histone deacetylase 6 0.0115 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0036 0.0318 0.1086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Schistosoma mansoni histone deacetylase 0.0102 0.1124 0.1124
Leishmania major histone deacetylase, putative 0.0102 0.1124 0.8668
Echinococcus multilocularis histone deacetylase 3 0.0102 0.1124 0.1124
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1631 0.5563
Echinococcus multilocularis geminin 0.0205 0.2366 0.2366
Onchocerca volvulus 0.002 0.0126 0.0293
Loa Loa (eye worm) histone deacetylase 1 0.0102 0.1124 0.3834
Trypanosoma brucei histone deacetylase 2 0.0049 0.048 0.3725
Trypanosoma cruzi histone deacetylase 1, putative 0.0102 0.1124 0.8793
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0366 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0422 0.3268
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0431
Onchocerca volvulus 0.0014 0.0045 0.0049
Echinococcus granulosus cathepsin l1 0.002 0.0126 0.0126
Echinococcus granulosus histone deacetylase 7 0.0115 0.1278 0.1278
Plasmodium vivax histone deacetylase 2, putative 0.0115 0.1278 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0126 0.0126
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0366 0.5
Trypanosoma brucei histone deacetylase 4 0.0115 0.1278 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0422 0.0422
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Brugia malayi nuclear receptor NHR-88 0.0012 0.0029 0.0099
Plasmodium vivax vivapain-2 0.002 0.0126 0.0937
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0422 0.124
Brugia malayi nuclear hormone receptor 0.0012 0.0029 0.0099
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus multilocularis histone deacetylase 0.0115 0.1278 0.1278
Onchocerca volvulus 0.002 0.0126 0.0293
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0126 0.0408
Brugia malayi Cathepsin L-like precursor 0.002 0.0126 0.0431
Trypanosoma cruzi histone deacetylase, putative 0.0115 0.1278 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0029 0.0099
Brugia malayi histone deacetylase 1 (HD1) 0.0102 0.1124 0.3834
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0029 0.0029
Loa Loa (eye worm) histone deacetylase 7A 0.0115 0.1278 0.4357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.0551
Toxoplasma gondii histone deacetylase HDAC4 0.0049 0.048 0.3076
Trypanosoma cruzi histone deacetylase, putative 0.0049 0.048 0.3725
Loa Loa (eye worm) hypothetical protein 0.0066 0.0678 0.2312
Echinococcus granulosus histone deacetylase 0.0115 0.1278 0.1278
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0029 0.0099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Loa Loa (eye worm) histone deacetylase 0.0115 0.1278 0.4357
Giardia lamblia Histone deacetylase 0.0102 0.1124 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0029 0.0029
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0126 0.0937
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0551 0.188
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.0551
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0029 0.0029
Plasmodium vivax SET domain protein, putative 0.0036 0.0318 0.245
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0422 0.1424
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0422 0.3268
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Brugia malayi Histone deacetylase family protein 0.0115 0.1278 0.4357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Loa Loa (eye worm) inositol-1 0.0045 0.0422 0.144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0318 0.0318
Trypanosoma cruzi histone deacetylase 1, putative 0.0102 0.1124 0.8793
Onchocerca volvulus 0.0182 0.2097 0.6218
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0029 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0126 0.0431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Plasmodium falciparum histone deacetylase 2 0.0115 0.1278 1
Schistosoma mansoni histone deacetylase 4 5 0.0115 0.1278 0.1278
Leishmania major cathepsin L-like protease 0.0077 0.0816 0.5992
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3354 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0029 0.0029
Onchocerca volvulus 0.002 0.0126 0.0293
Loa Loa (eye worm) hypothetical protein 0.0049 0.048 0.1638
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0029 0.0099
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0816 0.6368
Plasmodium falciparum histone deacetylase 1 0.0102 0.1124 0.8793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0318 0.0318
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.002 0.0126 0.0408
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0029 0.0099
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0029 0.0029
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0126 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0318 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0045 0.0113
Brugia malayi cathepsin L-like precursor 0.0014 0.0045 0.0154
Loa Loa (eye worm) ctsf protein 0.002 0.0126 0.0431
Trichomonas vaginalis AGC family protein kinase 0.025 0.2923 0.871
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0007 0.0007
Echinococcus granulosus histone deacetylase 8 0.0049 0.048 0.048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0029 0.0099
Loa Loa (eye worm) hypothetical protein 0.0182 0.2097 0.7149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0029 0.0029
Onchocerca volvulus 0.002 0.0126 0.0293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0126 0.0937
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0029 0.0099
Schistosoma mansoni histone deacetylase 4 5 0.0115 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Trichomonas vaginalis AGC family protein kinase 0.025 0.2923 0.871
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0318 0.1669
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0029 0.0099
Echinococcus multilocularis histone deacetylase 7 0.0115 0.1278 0.1278
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0126 0.0937
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0126 0.0126
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0029 0.0029
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Entamoeba histolytica protein kinase, putative 0.025 0.2923 1
Echinococcus multilocularis histone deacetylase 8 0.0049 0.048 0.048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0029 0.0099
Onchocerca volvulus 0.002 0.0126 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0029 0.0099
Trichomonas vaginalis histone deacetylase, putative 0.0102 0.1124 0.3338
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0765 0.261
Leishmania major histone deacetylase, putative 0.0115 0.1278 1
Leishmania major histone deacetylase, putative 0.0102 0.1124 0.8668
Trypanosoma cruzi histone deacetylase, putative 0.0049 0.048 0.3725
Loa Loa (eye worm) cysteine protease 0.002 0.0126 0.0431
Toxoplasma gondii histone deacetylase HDAC1 0.0115 0.1278 1
Trichomonas vaginalis histone deacetylase, putative 0.0102 0.1124 0.3338
Leishmania major cathepsin L-like protease 0.0077 0.0816 0.5992
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0126 0.0431
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0126 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0029 0.0099
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0029 0.0099
Leishmania major histone deacetylase, putative 0.0115 0.1278 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0029 0.0029
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.025 0.2923 0.9966
Onchocerca volvulus 0.002 0.0126 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0029 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Echinococcus granulosus histone deacetylase 6 0.0122 0.1365 0.1365
Loa Loa (eye worm) hypothetical protein 0.0102 0.1124 0.3834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Schistosoma mansoni hypothetical protein 0.0205 0.2366 0.2366
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Schistosoma mansoni hypothetical protein 0.0205 0.2366 0.2366
Plasmodium vivax histone deacetylase, putative 0.0115 0.1278 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0422 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0551 0.0551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0126 0.0431
Echinococcus multilocularis cysteine protease 0.002 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0029 0.0099
Loa Loa (eye worm) fibroinase 0.002 0.0126 0.0431
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0126 0.0126
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0422 0.124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0029 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0029 0.0029
Brugia malayi ecdysteroid receptor 0.0012 0.0029 0.0099
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0422 0.2571
Plasmodium vivax vivapain-2 0.002 0.0126 0.0937
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0045 0.0154
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0422 0.3268
Schistosoma mansoni coup transcription factor 0.0012 0.0029 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0816 0.6368
Echinococcus granulosus cysteine protease 0.001 0.0007 0.0007
Brugia malayi Cathepsin L-like precursor 0.002 0.0126 0.0431
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Trypanosoma brucei histone deacetylase 3 0.0115 0.1278 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0029 0.0099
Schistosoma mansoni histone deacetylase hda2 0.0122 0.1365 0.1365
Brugia malayi histone deacetylase 3 (HD3) 0.0102 0.1124 0.3834
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0029 0.0029
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0045 0.013
Echinococcus granulosus geminin 0.0205 0.2366 0.2366
Brugia malayi Histone deacetylase 1 0.0102 0.1124 0.3834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Plasmodium falciparum histone deacetylase, putative 0.0115 0.1278 1
Toxoplasma gondii histone deacetylase HDAC2 0.0102 0.1124 0.8668
Schistosoma mansoni serine/threonine protein kinase 0.025 0.2923 0.2923
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0422 0.124
Brugia malayi MH2 domain containing protein 0.0144 0.1631 0.5563
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1631 0.5563
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0816 0.6368
Onchocerca volvulus Histone deacetylase 10 homolog 0.0049 0.048 0.1358
Brugia malayi Cathepsin L-like precursor 0.002 0.0126 0.0431
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0422 0.0422
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0029 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0126 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0029 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0029 0.0029
Brugia malayi histone deacetylase 11 0.0049 0.048 0.1638
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0616 0.4792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0126 0.0937
Entamoeba histolytica histone deacetylase, putative 0.0102 0.1124 0.3832
Loa Loa (eye worm) histone deacetylase 11 0.0049 0.048 0.1638
Onchocerca volvulus 0.002 0.0126 0.0293
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0029 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0029 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0318 0.0318
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0029 0.0029
Brugia malayi Pre-SET motif family protein 0.0251 0.2933 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0551 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0029 0.0099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Trypanosoma brucei histone deacetylase 1 0.0102 0.1124 0.8793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Onchocerca volvulus Cathepsin L homolog 0.002 0.0126 0.0293
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.025 0.2923 0.9966
Toxoplasma gondii histone deacetylase HDAC5 0.0049 0.048 0.3076
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0077 0.0816 0.5992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.0551
Plasmodium vivax histone deacetylase 1, putative 0.0102 0.1124 0.8793
Brugia malayi Pre-SET motif family protein 0.0036 0.0318 0.1086
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0422 0.2571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Brugia malayi Cathepsin L-like precursor 0.0014 0.0045 0.0154
Schistosoma mansoni histone deacetylase 1 2 3 0.0049 0.048 0.048
Loa Loa (eye worm) histone deacetylase 3 0.0102 0.1124 0.3834
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Brugia malayi hypothetical protein 0.0182 0.2097 0.7149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0029 0.0099
Trypanosoma brucei histone deacetylase, putative 0.0115 0.1278 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0029 0.0029
Brugia malayi phosphoinositide-dependent protein kinase I 0.025 0.2923 0.9966
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0318 0.0318
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0551 0.0551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0126 0.0356
Echinococcus granulosus cathepsin l1 0.0014 0.0045 0.0045
Trichomonas vaginalis histone deacetylase, putative 0.0102 0.1124 0.3338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0816 0.6368
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0102 0.1124 0.3338
Trichomonas vaginalis histone deacetylase, putative 0.0102 0.1124 0.3338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0551 0.0551
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.025 0.2923 0.2923

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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