Detailed information for compound 1646752

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.296 | Formula: C18H11F2N3O
  • H donors: 1 H acceptors: 2 LogP: 3.77 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1cc(=O)n2c([nH]1)c(cn2)c1ccc(cc1)F
  • InChi: 1S/C18H11F2N3O/c19-13-5-1-11(2-6-13)15-10-21-23-17(24)9-16(22-18(15)23)12-3-7-14(20)8-4-12/h1-10,22H
  • InChiKey: HNZBELVVHGZHII-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL No references
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens cell division cycle 7 Starlite/ChEMBL No references
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0137 0.1637 0.5578
Echinococcus multilocularis neuropeptide Y receptor 0.0137 0.1637 0.5316
Echinococcus granulosus allatostatin A receptor 0.0137 0.1637 0.5316
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.0423 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0137 0.1637 0.5316
Echinococcus granulosus neuropeptides capa receptor 0.0137 0.1637 0.5316
Onchocerca volvulus 0.018 0.2507 0.8775
Echinococcus multilocularis neuropeptides capa receptor 0.0137 0.1637 0.5316
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0137 0.1637 0.1637
Echinococcus granulosus protein kinase 0.0077 0.0417 0.1355
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Schistosoma mansoni amine GPCR 0.0137 0.1637 0.5316
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0197 0.284 0.9222
Schistosoma mansoni opsin-like receptor 0.0137 0.1637 0.5316
Echinococcus granulosus 7TM GPCR rhodopsin 0.0137 0.1637 0.5316
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0137 0.1637 0.5316
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0137 0.1637 0.5316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0137 0.1637 0.1637
Onchocerca volvulus 0.0137 0.1637 0.5578
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.1637 0.5316
Schistosoma mansoni alpha-1 adrenergic receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0197 0.284 0.9222
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.1637 0.5316
Schistosoma mansoni protein kinase 0.0077 0.0417 0.1355
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi AKH receptor 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Schistosoma mansoni hypothetical protein 0.0137 0.1637 0.5316
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.012 0.2833
Onchocerca volvulus 0.0137 0.1637 0.5578
Echinococcus granulosus neuropeptide receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus sex peptide receptor 0.0137 0.1637 0.5316
Plasmodium falciparum protein serine/threonine kinase-1 0.0077 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Onchocerca volvulus 0.0137 0.1637 0.5578
Brugia malayi sulfakinin receptor protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) melatonin receptor type 1A 0.0137 0.1637 0.1637
Plasmodium vivax serine/threonine kinase-1, putative 0.0077 0.0423 1
Echinococcus granulosus somatostatin receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) CDC7 protein kinase 0.0073 0.0337 0.0337
Echinococcus granulosus neuropeptide s receptor 0.0137 0.1637 0.5316
Echinococcus granulosus tachykinin peptides receptor 99D 0.0137 0.1637 0.5316
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0137 0.1637 0.5316
Echinococcus granulosus biogenic amine 5HT receptor 0.0137 0.1637 0.5316
Schistosoma mansoni biogenic amine receptor 0.0137 0.1637 0.5316
Schistosoma mansoni serine/threonine protein kinase 0.018 0.2507 0.814
Brugia malayi ORL1-like opioid receptor 0.0137 0.1637 0.1637
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Schistosoma mansoni neuropeptide receptor 0.0137 0.1637 0.5316
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Echinococcus multilocularis g protein coupled receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.012 0.2833
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Trypanosoma brucei protein kinase, putative 0.0062 0.012 0.2833
Echinococcus granulosus neuropeptide receptor A26 0.0137 0.1637 0.5316
Onchocerca volvulus 0.0137 0.1637 0.5578
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.012 0.2833
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.0423 1
Entamoeba histolytica protein kinase domain containing protein 0.0208 0.308 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0077 0.0423 0.0423
Onchocerca volvulus 0.0137 0.1637 0.5578
Echinococcus multilocularis protein kinase shaggy 0.0062 0.012 0.0389
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus biogenic amine 5HT receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis G-protein coupled receptor, putative 0.0137 0.1637 0.5316
Echinococcus granulosus neuropeptide receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Echinococcus granulosus g protein coupled receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) neuropeptide F receptor 0.0137 0.1637 0.1637
Brugia malayi Serotonin receptor 0.0137 0.1637 0.1637
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0208 0.308 0.308
Echinococcus granulosus g protein coupled receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.284 0.284
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0137 0.1637 0.1637
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0137 0.1637 0.5316
Onchocerca volvulus 0.0073 0.0337 0.0799
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.012 0.012
Echinococcus granulosus CDC7 cell division cycle 7 0.0073 0.0337 0.1095
Giardia lamblia Kinase, CMGC CLK 0.0077 0.0423 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Echinococcus granulosus g protein coupled receptor 0.0137 0.1637 0.5316
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Schistosoma mansoni neuropeptide F-like receptor 0.0137 0.1637 0.5316
Schistosoma mansoni biogenic amine receptor 0.0137 0.1637 0.5316
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.012 0.0389
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0137 0.1637 0.5316
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.284 0.9222
Schistosoma mansoni biogenic amine (5HT) receptor 0.0137 0.1637 0.5316
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi Dopamine receptor protein 2 0.0137 0.1637 0.1637
Brugia malayi larval opioid receptor 0.0137 0.1637 0.1637
Schistosoma mansoni hypothetical protein 0.0137 0.1637 0.5316
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0137 0.1637 0.5316
Schistosoma mansoni growth hormone secretagogue receptor 0.0137 0.1637 0.5316
Giardia lamblia Kinase, CMGC GSK 0.0062 0.012 0.2833
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0137 0.1637 0.5316
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0197 0.284 1
Loa Loa (eye worm) G-protein coupled receptor 0.0137 0.1637 0.1637
Echinococcus granulosus neuropeptide Y receptor 0.0137 0.1637 0.5316
Onchocerca volvulus 0.0137 0.1637 0.5578
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Onchocerca volvulus 0.0137 0.1637 0.5578
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Brugia malayi putative neuropeptide receptor 0.0137 0.1637 0.1637
Echinococcus multilocularis fmrfamide receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis fmrfamide receptor 0.0137 0.1637 0.5316
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0423 0.1374
Brugia malayi Dopamine receptor 0.0137 0.1637 0.1637
Schistosoma mansoni neuropeptide receptor 0.0137 0.1637 0.5316
Schistosoma mansoni biogenic amine receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0337 0.1095
Schistosoma mansoni neuropeptide receptor 0.0137 0.1637 0.5316
Schistosoma mansoni opsin-like receptor 0.0137 0.1637 0.5316
Brugia malayi GnHR receptor homolog 0.0137 0.1637 0.1637
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0077 0.0423 1
Echinococcus granulosus orexin receptor type 2 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Echinococcus multilocularis neuropeptides capa receptor 0.0137 0.1637 0.5316
Echinococcus granulosus neuropeptides capa receptor 0.0137 0.1637 0.5316
Brugia malayi Tachykinin-like peptides receptor 99D 0.0137 0.1637 0.1637
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0137 0.1637 0.5316
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.0423 1
Onchocerca volvulus 0.0137 0.1637 0.5578
Echinococcus multilocularis serotonin receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi G-protein coupled receptor 0.0137 0.1637 0.1637
Schistosoma mansoni histamine h1 receptor 0.0137 0.1637 0.5316
Echinococcus granulosus neuropeptide FF receptor 2 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis g-protein coupled receptor 0.0137 0.1637 0.5316
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.1637 0.5316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Loa Loa (eye worm) neuropeptide F receptor 0.0137 0.1637 0.1637
Brugia malayi neuropeptide F receptor 0.0137 0.1637 0.1637
Echinococcus multilocularis neuropeptide Y receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis serotonin receptor 0.0137 0.1637 0.5316
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis G protein coupled receptor 139 0.0137 0.1637 0.5316
Echinococcus multilocularis neuropeptide s receptor 0.0137 0.1637 0.5316
Echinococcus granulosus rho-associated protein kinase 1 0.018 0.2507 0.814
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi neuropeptide F receptor 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0337 0.797
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus g-protein coupled receptor 0.0137 0.1637 0.5316
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0137 0.1637 0.5316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.055 1 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0208 0.308 0.308
Entamoeba histolytica protein kinase, putative 0.0062 0.012 0.0389
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0077 0.0423 1
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.012 0.2833
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0137 0.1637 0.1637
Echinococcus multilocularis 0.0077 0.0417 0.1355
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.1637 0.5316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Echinococcus granulosus neuropeptide Y receptor 0.0137 0.1637 0.5316
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.0936 0.3041
Echinococcus granulosus dro:myosuppressin receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0137 0.1637 0.5316
Schistosoma mansoni amine GPCR 0.0137 0.1637 0.5316
Echinococcus multilocularis neuropeptide receptor A26 0.0137 0.1637 0.5316
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.284 0.284
Onchocerca volvulus 0.0137 0.1637 0.5578
Echinococcus granulosus G protein coupled receptor 139 0.0137 0.1637 0.5316
Loa Loa (eye worm) TYRA-2 protein 0.0137 0.1637 0.1637
Echinococcus granulosus dual specificity protein kinase clk2 0.0077 0.0423 0.1374
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.012 0.0389
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi Dopamine receptor protein 1 0.0137 0.1637 0.1637
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0137 0.1637 0.5316
Schistosoma mansoni amine GPCR 0.0137 0.1637 0.5316
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0137 0.1637 0.5316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.1637 0.5316
Brugia malayi intracellular kinase 0.0062 0.012 0.012
Loa Loa (eye worm) G-protein coupled receptor 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0137 0.1637 0.1637
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.012 0.2833
Echinococcus multilocularis dual specificity protein kinase clk2 0.0077 0.0423 0.1374
Echinococcus multilocularis g protein coupled receptor 0.0137 0.1637 0.5316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0137 0.1637 0.5316
Onchocerca volvulus 0.0137 0.1637 0.5578
Schistosoma mansoni neuropeptide receptor 0.0137 0.1637 0.5316
Brugia malayi follicle stimulating hormone receptor 0.0137 0.1637 0.1637
Schistosoma mansoni neuropeptide F-like receptor 0.0137 0.1637 0.5316
Schistosoma mansoni adenoreceptor 0.0137 0.1637 0.5316
Echinococcus granulosus hypothetical protein 0.0072 0.0329 0.1069
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0137 0.1637 0.5316
Brugia malayi Protein kinase domain containing protein 0.0197 0.284 0.284
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0137 0.1637 0.1637
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0137 0.1637 0.1637
Onchocerca volvulus 0.0137 0.1637 0.5578
Leishmania major protein kinase, putative 0.0077 0.0423 1
Onchocerca volvulus 0.0137 0.1637 0.5578
Onchocerca volvulus 0.0137 0.1637 0.5578
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi RE15519p 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.012 0.2833
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi probable protein kinase 0.0107 0.103 0.103
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0423 1
Leishmania major protein kinase, putative 0.0077 0.0423 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Schistosoma mansoni protein kinase 0.0107 0.103 0.3346
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Brugia malayi G protein-coupled receptor F59B2.13 0.0137 0.1637 0.1637
Echinococcus multilocularis CDC7 cell division cycle 7 0.0073 0.0337 0.1095
Schistosoma mansoni amine GPCR 0.0137 0.1637 0.5316
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus peptide allatostatin:somatostatin 0.0137 0.1637 0.5316
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.012 0.2833
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0137 0.1637 0.5316
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.308 1
Echinococcus granulosus protein kinase shaggy 0.0062 0.012 0.0389
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.012 0.0389
Echinococcus multilocularis dro:myosuppressin receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Brugia malayi putative neuropeptide receptor NPR1 0.0137 0.1637 0.1637
Echinococcus multilocularis rho associated protein kinase 0.018 0.2507 0.814
Echinococcus granulosus alpha 1A adrenergic receptor 0.0137 0.1637 0.5316
Onchocerca volvulus 0.0137 0.1637 0.5578
Onchocerca volvulus 0.0073 0.0337 0.0799
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0137 0.1637 0.5316
Schistosoma mansoni amine GPCR 0.0137 0.1637 0.5316
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.1637 0.5316
Schistosoma mansoni myosin xvIII 0.0137 0.1637 0.5316
Brugia malayi Melatonin receptor type 1A 0.0137 0.1637 0.1637
Echinococcus multilocularis neuropeptide FF receptor 2 0.0137 0.1637 0.5316
Schistosoma mansoni biogenic amine (5HT) receptor 0.0137 0.1637 0.5316
Giardia lamblia Kinase, CMGC GSK 0.0062 0.012 0.2833
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus hypothetical protein 0.0137 0.1637 0.5316
Brugia malayi Serotonin receptor 0.0137 0.1637 0.1637
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0077 0.0417 0.0417
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0137 0.1637 0.5316
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0337 0.797
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0137 0.1637 0.5316
Echinococcus granulosus fmrfamide receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.012 0.012
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0137 0.1637 0.1637
Echinococcus granulosus 7tm_1 domain containing protein 0.0137 0.1637 0.5316
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.0423 1
Echinococcus multilocularis allatostatin A receptor 0.0137 0.1637 0.5316
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0337 0.797
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis orexin receptor type 2 0.0137 0.1637 0.5316
Schistosoma mansoni opsin-like receptor 0.0137 0.1637 0.5316
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.012 0.0389
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0137 0.1637 0.5316
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.1637 0.5316
Schistosoma mansoni hypothetical protein 0.0137 0.1637 0.5316
Echinococcus multilocularis neuropeptide receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis neuropeptide receptor 0.0137 0.1637 0.5316
Brugia malayi Protein kinase domain containing protein 0.0073 0.0337 0.0337
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.1637 0.5316
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.012 0.0389
Onchocerca volvulus 0.0137 0.1637 0.5578
Onchocerca volvulus Neuropeptide F receptor homolog 0.0137 0.1637 0.5578
Echinococcus granulosus serotonin receptor 0.0137 0.1637 0.5316
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0423 0.1374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.1637 0.5316
Echinococcus multilocularis somatostatin receptor 0.0137 0.1637 0.5316
Giardia lamblia Kinase, CDC7 0.0073 0.0337 0.797
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0137 0.1637 0.5316
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0197 0.284 0.284
Brugia malayi G protein-coupled receptor 0.0137 0.1637 0.1637
Echinococcus multilocularis g protein coupled receptor 0.0137 0.1637 0.5316
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0137 0.1637 0.5316
Schistosoma mansoni neuropeptide f receptor 76f 0.0137 0.1637 0.5316
Brugia malayi Protein kinase domain containing protein 0.0077 0.0423 0.0423
Brugia malayi hypothetical protein 0.0137 0.1637 0.1637
Brugia malayi G-protein coupled receptor 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0208 0.308 1
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0208 0.308 1
Echinococcus multilocularis 0.0072 0.0329 0.1069
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0077 0.0423 1
Onchocerca volvulus 0.0137 0.1637 0.5578
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Echinococcus multilocularis sex peptide receptor 0.0137 0.1637 0.5316
Schistosoma mansoni hypothetical protein 0.0137 0.1637 0.5316
Loa Loa (eye worm) hypothetical protein 0.0137 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0072 0.0329 0.0329
Onchocerca volvulus 0.0137 0.1637 0.5578
Onchocerca volvulus 0.0175 0.2413 0.843

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) > 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) > 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 6.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference
Ki (functional) = 6.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 6.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (functional) = 7.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 ChEMBL. No reference
Ki (functional) = 7.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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