Detailed information for compound 1648446

Basic information

Technical information
  • TDR Targets ID: 1648446
  • Name: NSC702425
  • MW: 483.487 | Formula: C28H20F3N5
  • H donors: 0 H acceptors: 3 LogP: 7.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn(c2c1c(c1ccc(cc1)C(F)(F)F)c1c(C)nn(c1n2)c1ccccc1)c1ccccc1
  • InChi: 1S/C28H20F3N5/c1-17-23-25(19-13-15-20(16-14-19)28(29,30)31)24-18(2)34-36(22-11-7-4-8-12-22)27(24)32-26(23)35(33-17)21-9-5-3-6-10-21/h3-16H,1-2H3
  • InChiKey: CVYQKPIIGFCRAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCI60_036695

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine protein kinase ATM 0.0094 0.0313 0.0304
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0052 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0052 0.0066
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0834
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0032 0.0052 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Brugia malayi hypothetical protein 0.004 0.0086 0.0979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Schistosoma mansoni hypothetical protein 0.0072 0.0223 0.3507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0094 0.0313 0.077
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0052 0.0396
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0166 0.0619 0.1673
Schistosoma mansoni fkbp-rapamycin associated protein 0.0094 0.0313 0.498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Echinococcus multilocularis 0.0032 0.0052 0.0043
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0086 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0028 0.5473
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0166 0.0619 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0032 0.0052 0.0043
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0052 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0032 0.0052 0.0396
Onchocerca volvulus 0.0032 0.0052 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0052 0.0834
Loa Loa (eye worm) phosphatidylinositol 3 0.0166 0.0619 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0166 0.0619 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0052 0.0396
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0166 0.0619 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0052 1
Leishmania major hypothetical protein, unknown function 0.0032 0.0052 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0096 0.1423
Loa Loa (eye worm) hypothetical protein 0.0045 0.0109 0.1754
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0166 0.0619 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0086 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Entamoeba histolytica hypothetical protein 0.004 0.0086 0.0979
Leishmania major hypothetical protein, conserved 0.0866 0.3578 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0052 0.0702
Schistosoma mansoni hypothetical protein 0.0157 0.058 0.9363
Loa Loa (eye worm) phosphatidylinositol kinase 0.0032 0.0052 0.0834
Schistosoma mansoni hypothetical protein 0.0023 0.0014 0.0082
Loa Loa (eye worm) hypothetical protein 0.0079 0.025 0.4037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0052 0.0396
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0028 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0052 0.0834
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0072 0.0223 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0104 0.0358 0.5399
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0096 0.114
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0457
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0166 0.0619 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0032 0.0052 1
Entamoeba histolytica protein kinase rad3, putative 0.0094 0.0313 0.4815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trypanosoma cruzi hypothetical protein, conserved 0.0834 0.3443 1
Schistosoma mansoni hypothetical protein 0.0157 0.058 0.9363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Entamoeba histolytica hypothetical protein 0.0032 0.0052 0.0396
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0166 0.0619 0.1673
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0032 0.0052 0.0834
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0052 0.0396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0096 0.1423
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0166 0.0619 0.1664
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0166 0.0619 0.1664
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0313 0.4815
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0028 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0096 0.0087
Plasmodium vivax hypothetical protein 0.0032 0.0052 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0096 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0358 0.5399
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0028 0.5473
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2385 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0166 0.0619 0.0611
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0166 0.0619 0.1673
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0028 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0166 0.0619 0.1664
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0166 0.0619 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0086 0.0077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0086 0.0077
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0094 0.0313 0.4601
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0028 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0032 0.0052 0.0066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0052 0.0396
Entamoeba histolytica hypothetical protein 0.004 0.0086 0.0979
Brugia malayi FAT domain containing protein 0.0072 0.0223 0.3293
Brugia malayi Bromodomain containing protein 0.0043 0.0097 0.1165
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0166 0.0619 0.0611
Mycobacterium ulcerans hypothetical protein 0.0026 0.0028 1
Brugia malayi Bromodomain containing protein 0.0084 0.027 0.4094
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0032 0.0052 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0052 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0094 0.0313 0.498
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0062 0.0178 0.0371
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0166 0.0619 0.0611
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0052 0.0396
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0094 0.0313 0.077
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0032 0.0052 0.0702
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0166 0.0619 0.0611
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0052 0.0702
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0032 0.0052 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Entamoeba histolytica hypothetical protein 0.004 0.0086 0.0979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0178 0.2219
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0198 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0032 0.0052 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0028 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0097 0.1573
Toxoplasma gondii target of rapamycin (TOR), putative 0.0166 0.0619 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0052 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Entamoeba histolytica hypothetical protein 0.0032 0.0052 0.0396
Brugia malayi PHD-finger family protein 0.0028 0.0034 0.0096
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0052 0.0396
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0166 0.0619 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0313 0.5051
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0028 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0032 0.0052 0.0702
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0052 0.0396
Echinococcus multilocularis serine protein kinase ATM 0.0094 0.0313 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0358 0.5399
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0023 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0178 0.2219
Leishmania major phosphatidylinositol kinase, putative 0.0032 0.0052 0.0066
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0052 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0052 0.0396
Entamoeba histolytica hypothetical protein 0.004 0.0086 0.0979
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0096 0.1545
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0032 0.0052 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0166 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0052 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0223 0.3017
Loa Loa (eye worm) hypothetical protein 0.0062 0.0178 0.2868
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0032 0.0052 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0313 0.4815
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0457
Loa Loa (eye worm) hypothetical protein 0.0048 0.0118 0.1899
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0104 0.0358 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0032 0.0052 0.0043
Trypanosoma cruzi target of rapamycin kinase 3 0.0166 0.0619 0.1673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0032 0.0052 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0032 0.0052 0.0043
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0032 0.0052 0.0043
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0032 0.0052 0.0043
Entamoeba histolytica hypothetical protein 0.0032 0.0052 0.0396
Toxoplasma gondii FATC domain-containing protein 0.0094 0.0313 0.4601
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0032 0.0052 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0166 0.0619 0.1664
Schistosoma mansoni hypothetical protein 0.004 0.0086 0.1267
Onchocerca volvulus 0.0032 0.0052 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0166 0.0619 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0032 0.0052 0.0066
Loa Loa (eye worm) hypothetical protein 0.0072 0.0223 0.3599
Schistosoma mansoni hypothetical protein 0.0032 0.0052 0.0702
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0834
Echinococcus multilocularis geminin 0.0157 0.058 0.0572
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0166 0.0619 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0032 0.0052 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0166 0.0619 0.1664
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0096 0.1423
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0052 0.0066
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0166 0.0619 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0358 0.5783
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0094 0.0313 0.0304
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0052 0.0043
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0086 0.1267
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0032 0.0052 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0032 0.0052 0.0043
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0904 0.374 0.3734
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0032 0.0052 0.0043
Echinococcus granulosus geminin 0.0157 0.058 0.0572
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0094 0.0313 0.4815
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0166 0.0619 0.1673
Entamoeba histolytica hypothetical protein 0.0094 0.0313 0.4815
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0032 0.0052 0.0396
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0032 0.0052 0.0396
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0052 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0166 0.0619 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0032 0.0052 0.0396
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0023 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Giardia lamblia GTOR 0.0166 0.0619 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0032 0.0052 0.0396
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0072 0.0223 0.0214
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0032 0.0052 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0313 0.4601
Entamoeba histolytica hypothetical protein 0.0032 0.0052 0.0396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0096 0.0087
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0198 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0096 0.0087
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0023 0.0014
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0014 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0619 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0094 0.0313 0.0304
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0052 0.0834
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0028 1
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0052 1
Schistosoma mansoni bromodomain containing protein 0.0071 0.0215 0.3377

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.141 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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