Detailed information for compound 16547

Basic information

Technical information
  • TDR Targets ID: 16547
  • Name: (5Z)-5-[(3,5-ditert-butyl-4-hydroxyphenyl)met hylidene]-2-(prop-2-enoxyamino)-1,3-thiazol-4 -one
  • MW: 388.524 | Formula: C21H28N2O3S
  • H donors: 2 H acceptors: 2 LogP: 5.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCONC1=NC(=O)/C(=C/c2cc(c(c(c2)C(C)(C)C)O)C(C)(C)C)/S1
  • InChi: 1S/C21H28N2O3S/c1-8-9-26-23-19-22-18(25)16(27-19)12-13-10-14(20(2,3)4)17(24)15(11-13)21(5,6)7/h8,10-12,24H,1,9H2,2-7H3,(H,22,23,25)/b16-12-
  • InChiKey: VOOYURWLZHBICA-VBKFSLOCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-2-(allyloxyamino)-5-[(3,5-ditert-butyl-4-hydroxy-phenyl)methylene]thiazol-4-one
  • (5Z)-2-(allyloxyamino)-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylene]-4-thiazolone
  • (5Z)-5-[(3,5-ditert-butyl-4-hydroxy-phenyl)methylidene]-2-(prop-2-enoxyamino)-1,3-thiazol-4-one
  • (5Z)-2-(allyloxyamino)-5-(3,5-ditert-butyl-4-hydroxy-benzylidene)-2-thiazolin-4-one
  • (5Z)-2-(allyloxyamino)-5-(3,5-ditert-butyl-4-hydroxy-benzylidene)thiazol-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Mus musculus prostaglandin-endoperoxide synthase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0034 0.0507 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Giardia lamblia Hexose transporter 0.0031 0.044 0.0286
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0492 0.1083
Schistosoma mansoni hypothetical protein 0.0089 0.1697 0.3734
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.044 0.0552
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0391 0.8206 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Schistosoma mansoni slit 0.0021 0.0212 0.0466
Schistosoma mansoni hypothetical protein 0.0021 0.0212 0.0466
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0212 0.0265
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0307 0.0385
Onchocerca volvulus 0.0391 0.8206 1
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.114 0.1389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.013 0.0163
Brugia malayi Delta serrate ligand family protein 0.0021 0.0212 0.0258
Onchocerca volvulus 0.0028 0.0364 0.0444
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Schistosoma mansoni notch 0.0021 0.0212 0.0466
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0161 0.3253 0.5662
Schistosoma mansoni glutamate receptor AMPA 0.0063 0.1128 0.2483
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0166 0.3349 0.7372
Brugia malayi Animal haem peroxidase family protein 0.0063 0.114 0.1389
Entamoeba histolytica hypothetical protein 0.0025 0.0307 0.0124
Echinococcus granulosus tyrosine kinase 0.0032 0.0465 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.044 0.032
Plasmodium vivax sugar transporter, putative 0.0031 0.044 0.0261
Onchocerca volvulus 0.0031 0.044 0.0536
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.024 0.0071
Brugia malayi Animal haem peroxidase family protein 0.0063 0.114 0.1389
Echinococcus multilocularis fat cadherin tumor suppressor 0.0021 0.0212 0.0265
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0391 0.8206 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.044 0.0536
Entamoeba histolytica hypothetical protein 0.0032 0.0465 0.0323
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0095 0.1825 0.2288
Brugia malayi major facilitator superfamily protein 0.0031 0.044 0.0536
Schistosoma mansoni protein kinase 0.0032 0.0465 0.1025
Echinococcus multilocularis glutamate receptor 2 0.0095 0.1825 0.2288
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0084 0.1574 0.3463
Loa Loa (eye worm) hypothetical protein 0.0229 0.4713 0.5744
Plasmodium vivax hexose transporter 0.0221 0.4543 0.4441
Loa Loa (eye worm) hypothetical protein 0.0077 0.1421 0.1732
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0816 0.1023
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.1244 0.2737
Brugia malayi Guanylyl cyclase protein 23 0.0032 0.0465 0.0567
Brugia malayi calpain family protein 1 0.0068 0.1244 0.1515
Entamoeba histolytica protein kinase, putative 0.0034 0.0507 0.0374
Brugia malayi hypothetical protein 0.0063 0.114 0.1389
Onchocerca volvulus 0.0031 0.044 0.0536
Echinococcus granulosus calpain A 0.0072 0.1319 0.1654
Schistosoma mansoni glutamate receptor kainate 0.0063 0.1128 0.2483
Brugia malayi Receptor family ligand binding region containing protein 0.0032 0.0465 0.0567
Onchocerca volvulus Peroxidasin homolog 0.0063 0.114 0.1389
Onchocerca volvulus Peroxidase homolog 0.0063 0.114 0.1389
Onchocerca volvulus 0.0021 0.0212 0.0258
Brugia malayi Blistered cuticle protein 3 0.0063 0.114 0.1389
Leishmania major protein kinase, putative 0.0034 0.0507 0.1384
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.013 0.0158
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0507 0.033
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0212 0.0265
Echinococcus multilocularis NMDA receptor 0.0063 0.1128 0.1414
Brugia malayi calpain 7 0.002 0.0207 0.0253
Echinococcus granulosus glutamate receptor 2 0.0032 0.0465 0.0584
Schistosoma mansoni sugar transporter 0.0031 0.044 0.0968
Leishmania major glucose transporter, lmgt3 0.0069 0.1249 0.4819
Schistosoma mansoni serine-rich repeat protein 0.0089 0.1697 0.3734
Brugia malayi Glutamate receptor 2 precursor 0.0063 0.1128 0.1375
Brugia malayi Cadherin domain containing protein 0.0021 0.0212 0.0258
Trichomonas vaginalis glucose transporter, putative 0.0069 0.1249 0.1329
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0492 0.0617
Brugia malayi calpain 5 0.002 0.0207 0.0253
Echinococcus multilocularis voltage dependent calcium channel subunit 0.038 0.7976 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0021 0.0212 0.0265
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0307 0.0345
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0612 0.1869
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0307 0.0126
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0032 0.0465 0.0584
Schistosoma mansoni calpain C (C02 family) 0.002 0.0207 0.0457
Onchocerca volvulus 0.0032 0.0465 0.0567
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.4543 0.5696
Schistosoma mansoni glutamate receptor NMDA 0.0095 0.1825 0.4017
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0307 0.0385
Echinococcus granulosus calpain 5 0.002 0.0207 0.026
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0207 0.0457
Brugia malayi GCC2 and GCC3 family protein 0.0021 0.0212 0.0258
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.018 0.3664 0.3546
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.4543 0.5434
Toxoplasma gondii EGF family domain-containing protein 0.0021 0.0212 0.0044
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0492 0.0599
Echinococcus granulosus neural cadherin 0.0021 0.0212 0.0265
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0343 0.0199
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0183 0.0195
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0212 0.0265
Schistosoma mansoni glutamate receptor kainate 0.0063 0.1128 0.2483
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0507 0.1115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0816 0.1023
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Trypanosoma cruzi sugar transporter, putative 0.0031 0.044 0.1075
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0612 0.1869
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.044 0.0536
Brugia malayi Animal haem peroxidase family protein 0.0063 0.114 0.1389
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0072 0.1319 0.1654
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0027 0.0343 0.0756
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.114 0.1389
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0507 0.033
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0391 0.8206 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0364 0.0444
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0391 0.8206 1
Loa Loa (eye worm) Notch2 0.0021 0.0212 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0307 0.0126
Schistosoma mansoni hypothetical protein 0.0221 0.4543 1
Echinococcus granulosus solute carrier family 22 0.0031 0.044 0.0552
Schistosoma mansoni calpain (C02 family) 0.002 0.0207 0.0457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.044 0.032
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Trypanosoma cruzi glucose transporter, putative 0.0031 0.044 0.1075
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.044 0.0536
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0161 0.3253 0.3946
Schistosoma mansoni tyrosine kinase 0.0032 0.0465 0.1025
Trypanosoma brucei glucose transporter 2A 0.0069 0.1249 0.4819
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0307 0.0459
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0161 0.3253 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Echinococcus multilocularis nmda type glutamate receptor 0.0224 0.4612 0.5783
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0069 0.1249 0.1329
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0236 0.4873 0.611
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Loa Loa (eye worm) hypothetical protein 0.0028 0.0364 0.0444
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.2369 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Echinococcus multilocularis notch 0.0021 0.0212 0.0265
Brugia malayi EGF-like domain containing protein 0.0021 0.0212 0.0258
Leishmania major extracellular receptor, putative 0.0032 0.0465 0.1193
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0226 0.137
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Onchocerca volvulus 0.0021 0.0212 0.0258
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Onchocerca volvulus Putative cubilin 0.0021 0.0212 0.0258
Echinococcus granulosus neurogenic locus protein delta 0.0021 0.0212 0.0265
Schistosoma mansoni notch 0.0021 0.0212 0.0466
Onchocerca volvulus 0.0048 0.0805 0.0981
Schistosoma mansoni notch 0.0021 0.0212 0.0466
Loa Loa (eye worm) RGC/RGC protein kinase 0.0032 0.0465 0.0567
Schistosoma mansoni notch 0.0021 0.0212 0.0466
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0507 0.033
Brugia malayi EGF-like domain containing protein 0.0021 0.0212 0.0258
Brugia malayi hypothetical protein 0.0031 0.044 0.0536
Toxoplasma gondii sugar transporter ST1 0.0031 0.044 0.0401
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Onchocerca volvulus Putative transporter 0.0031 0.044 0.0536
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.044 0.0508
Echinococcus multilocularis solute carrier family 22 0.0031 0.044 0.0552
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0461 0.0578
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Leishmania major glucose transporter, lmgt2 0.0069 0.1249 0.4819
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0072 0.1319 0.2903
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0343 0.0199
Echinococcus multilocularis hypothetical protein 0.002 0.0207 0.026
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0549 0.0669
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.044 0.032
Loa Loa (eye worm) sugar transporter 0.0221 0.4543 0.5536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.4543 0.5696
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.044 0.032
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0207 0.0457
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.044 0.0536
Schistosoma mansoni glucose transporter 0.0031 0.044 0.0968
Echinococcus multilocularis fibropellin Ia 0.0021 0.0212 0.0265
Schistosoma mansoni hypothetical protein 0.0021 0.0212 0.0466
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.2369 0.2725
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0492 0.1083
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0032 0.0465 0.0567
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.044 0.1075
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0095 0.1825 0.2288
Echinococcus multilocularis calpain 5 0.002 0.0207 0.026
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0391 0.8206 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.013 0.0163
Echinococcus granulosus General substrate transporter 0.019 0.3872 0.4854
Loa Loa (eye worm) sugar transporter 0.0031 0.044 0.0536
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Schistosoma mansoni notch 0.0021 0.0212 0.0466
Schistosoma mansoni metabotropic glutamate receptor 0.0032 0.0465 0.1025
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.044 0.0508
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0391 0.8206 1
Schistosoma mansoni protein kinase 0.0034 0.0507 0.1115
Onchocerca volvulus 0.0063 0.114 0.1389
Brugia malayi Cam kinase protein 1 0.0034 0.0507 0.0618
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.1249 0.1329
Plasmodium falciparum protein kinase 7 0.0315 0.658 0.6516
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0492 0.0599
Entamoeba histolytica protein kinase, putative 0.0022 0.0254 0.0058
Echinococcus granulosus voltage dependent calcium channel subunit 0.038 0.7976 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0027 0.0343 0.0628
Brugia malayi N-terminal motif family protein 0.0191 0.3902 0.4755
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0492 1
Loa Loa (eye worm) calpain family protein 1 0.0068 0.1244 0.1515
Trypanosoma cruzi hexose transporter, putative 0.0069 0.1249 0.4819
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0226 0.0078
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Echinococcus multilocularis nmda type glutamate receptor 0.0032 0.0465 0.0584
Echinococcus multilocularis protein jagged 1 0.0021 0.0212 0.0265
Toxoplasma gondii sugar transporter ST2 0.0031 0.044 0.0401
Onchocerca volvulus 0.0031 0.044 0.0536
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0343 0.0628
Schistosoma mansoni sugar transporter 0.0031 0.044 0.0968
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0507 0.033
Brugia malayi Animal haem peroxidase family protein 0.0063 0.114 0.1389
Onchocerca volvulus Peroxidasin homolog 0.0063 0.114 0.1389
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0021 0.0212 0.0258
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0095 0.1825 0.2288
Schistosoma mansoni glucose transport protein 0.0221 0.4543 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0507 0.033
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0612 0.1869
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.012 0.2369 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0032 0.0465 0.0584
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Toxoplasma gondii protein kinase, putative 0.0315 0.658 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0391 0.8206 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0072 0.1319 0.2903
Leishmania major glucose transporter/membrane transporter D2, putative 0.0069 0.1249 0.4819
Loa Loa (eye worm) hypothetical protein 0.0017 0.013 0.0158
Loa Loa (eye worm) hypothetical protein 0.0027 0.0356 0.0434
Brugia malayi Peroxidasin 0.0063 0.114 0.1389
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0212 0.0258
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0095 0.1825 0.2288
Onchocerca volvulus 0.0063 0.114 0.1389
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0032 0.0465 0.0567
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.4543 0.5696
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0612 0.1869
Loa Loa (eye worm) RGC/RGC protein kinase 0.0032 0.0465 0.0567
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0507 0.0635
Onchocerca volvulus 0.0021 0.0212 0.0258
Loa Loa (eye worm) hypothetical protein 0.0068 0.1244 0.1515
Leishmania major hypothetical protein, conserved 0.0031 0.044 0.1075
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Trypanosoma cruzi hexose transporter, putative 0.0069 0.1249 0.4819
Brugia malayi Sugar transporter family protein 0.0221 0.4543 0.5536
Onchocerca volvulus Chorion peroxidase homolog 0.0063 0.114 0.1389
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0095 0.1825 0.2288
Loa Loa (eye worm) hypothetical protein 0.0027 0.0343 0.0418
Echinococcus granulosus protein jagged 2 0.0021 0.0212 0.0265
Plasmodium vivax CDK-related protein kinase 6, putative 0.0474 1 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.044 0.0473
Echinococcus multilocularis calpain 0.002 0.0207 0.026
Echinococcus granulosus protein jagged 2 0.0021 0.0212 0.0265
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0191 0.3902 0.4755
Toxoplasma gondii sugar transporter ST3 0.0031 0.044 0.0401
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Echinococcus granulosus nmda type glutamate receptor 0.0224 0.4612 0.5783
Brugia malayi EGF-like domain containing protein 0.0021 0.0212 0.0258
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0507 0.1384
Echinococcus granulosus atrial natriuretic peptide receptor 0.0032 0.0465 0.0584
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.044 0.0968
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0507 0.033
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.044 0.0552
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0063 0.1128 0.1414
Onchocerca volvulus Neurogenic locus notch homolog 0.0021 0.0212 0.0258
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0578 0.1714
Schistosoma mansoni glutamate receptor AMPA 0.0063 0.1128 0.2483
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0816 0.1796
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0343 0.0418
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0507 0.0635
Loa Loa (eye worm) RGC/RGC protein kinase 0.0032 0.0465 0.0567
Onchocerca volvulus Slit protein homolog 0.0021 0.0212 0.0258
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Loa Loa (eye worm) hypothetical protein 0.0036 0.0549 0.0669
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0391 0.8206 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0307 0.0154
Echinococcus granulosus receptor type guanylyl cyclase 0.0032 0.0465 0.0584
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.4543 0.5696
Echinococcus multilocularis GPCR, family 2 0.0017 0.013 0.0163
Echinococcus granulosus GPCR family 2 0.0017 0.013 0.0163
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0063 0.1128 0.1414
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0221 0.4543 0.5696
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0492 0.0617
Echinococcus granulosus protein jagged 1 0.0021 0.0212 0.0265
Schistosoma mansoni ATP-binding cassette transporter 0.0063 0.1128 0.2483
Onchocerca volvulus 0.0031 0.044 0.0536
Brugia malayi EGF-like domain containing protein 0.0021 0.0212 0.0258
Trypanosoma cruzi hexose transporter, putative 0.0031 0.044 0.1075
Loa Loa (eye worm) notch protein 0.0021 0.0212 0.0258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0816 0.1796
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0507 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.044 0.032
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0612 0.0436
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.013 0.0163
Trypanosoma cruzi extracellular receptor, putative 0.0032 0.0465 0.1193
Schistosoma mansoni notch 0.0021 0.0212 0.0466
Schistosoma mansoni sugar transporter 0.0031 0.044 0.0968
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0286
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.044 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0183 0.0195
Onchocerca volvulus 0.0031 0.044 0.0536
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.1249 0.4819
Onchocerca volvulus 0.0031 0.044 0.0536
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0207 0.0457
Trypanosoma brucei sugar transporter, putative 0.0031 0.044 0.1075
Echinococcus granulosus solute carrier family 22 0.0031 0.044 0.0552
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0816 0.1796
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.4543 0.5696
Echinococcus granulosus fibropellin Ia 0.0021 0.0212 0.0265
Schistosoma mansoni peroxidasin 0.0063 0.114 0.2508
Schistosoma mansoni sugar transporter 0.0031 0.044 0.0968
Echinococcus multilocularis tyrosine kinase 0.0032 0.0465 0.0584
Brugia malayi Animal haem peroxidase family protein 0.0063 0.114 0.1389
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Echinococcus granulosus calpain 0.002 0.0207 0.026
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.018 0.3664 0.5442
Schistosoma mansoni glucose transport protein 0.0221 0.4543 1
Brugia malayi calpain family protein 1 0.0068 0.1244 0.1515
Onchocerca volvulus 0.0031 0.044 0.0536
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0286
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0032 0.0465 0.0567
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0095 0.1825 0.2288
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0507 0.0635
Trypanosoma brucei glucose transporter 1E 0.0069 0.1249 0.4819
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.4543 0.5696
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Leishmania major glucose transporter, lmgt1 0.0069 0.1249 0.4819
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0063 0.1128 0.1414
Echinococcus multilocularis receptor type guanylyl cyclase 0.0032 0.0465 0.0584
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0507 0.0635
Brugia malayi metabotropic glutamate receptor type 2 0.0032 0.0465 0.0567
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Echinococcus granulosus nmda type glutamate receptor 0.0032 0.0465 0.0584
Brugia malayi Cache domain containing protein 0.0077 0.1421 0.1732
Giardia lamblia Sugar-proton symporter 0.0031 0.044 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Plasmodium falciparum mitogen-activated protein kinase 2 0.018 0.3664 0.3546
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Echinococcus granulosus slit 2 protein 0.0021 0.0212 0.0265
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0507 0.0506
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0307 0.0675
Brugia malayi hypothetical protein 0.0032 0.0465 0.0567
Echinococcus multilocularis protein jagged 1 0.0021 0.0212 0.0265
Mycobacterium ulcerans sugar transporter 0.0031 0.044 0.0508
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0492 0.0355
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Onchocerca volvulus 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0034 0.0507 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Echinococcus multilocularis slit 2 protein 0.0021 0.0212 0.0265
Onchocerca volvulus 0.0031 0.044 0.0536
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.091 0.1109
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0027 0.0343 0.043
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0063 0.1128 0.1414
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0507 0.0506
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0816 0.1023
Echinococcus multilocularis solute carrier family 22 0.0031 0.044 0.0552
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0095 0.1825 0.2288
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.013 0.0163
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0063 0.1128 0.1414
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0307 0.0459
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0507 0.0506
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0224 0.4612 0.5783
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0507 0.0635
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.044 0.032
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0212 0.0265
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.114 0.1389
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0028 0.0364 0.0444
Leishmania major hypothetical protein, conserved 0.012 0.2369 1
Echinococcus granulosus voltage dependent calcium channel subunit 0.0173 0.3501 0.439
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0032 0.0465 0.0567
Schistosoma mansoni hypothetical protein 0.0063 0.1128 0.2483
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0212 0.0265
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0461 0.0578
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Loa Loa (eye worm) hypothetical protein 0.021 0.4299 0.5238
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0343 0.0756
Loa Loa (eye worm) hypothetical protein 0.0033 0.0492 0.0599
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0183 0.0195
Loa Loa (eye worm) glutamate receptor 0.0032 0.0465 0.0567
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0583 0.0407
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.2369 0.2725
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Onchocerca volvulus 0.0031 0.044 0.0536
Echinococcus granulosus glutamate receptor subunit protein glur 0.0063 0.1128 0.1414
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0021 0.0212 0.0466
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0391 0.8206 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.114 0.1389
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Onchocerca volvulus 0.0031 0.044 0.0536
Schistosoma mansoni laminin gamma-3 chain 0.0021 0.0212 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0307 0.0119
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0507 0.0635
Schistosoma mansoni metabotropic glutamate receptor 0.0032 0.0465 0.1025
Brugia malayi Sugar transporter family protein 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Brugia malayi notch-like transmembrane receptor 0.0021 0.0212 0.0258
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0465 0.0584
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0286
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Echinococcus multilocularis protein jagged 2 0.0021 0.0212 0.0265
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.027 0.5605 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0507 0.0635
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0063 0.1128 0.1414
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0027 0.0343 0.0628
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0612 0.067
Trypanosoma cruzi hexose transporter 0.0069 0.1249 0.4819
Loa Loa (eye worm) calpain family protein 1 0.0048 0.0805 0.0981
Brugia malayi EGF-like domain containing protein 0.0021 0.0212 0.0258
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0212 0.0258
Brugia malayi EGF-like domain containing protein 0.0021 0.0212 0.0258
Echinococcus multilocularis solute carrier family 22 0.0031 0.044 0.0552
Echinococcus granulosus metabotropic glutamate receptor 2 0.0032 0.0465 0.0584
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0286
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0492 0.0351
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.044 0.1075
Schistosoma mansoni peroxidasin 0.0063 0.114 0.2508
Onchocerca volvulus 0.0063 0.114 0.1389
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Brugia malayi Receptor family ligand binding region containing protein 0.0032 0.0465 0.0567
Echinococcus granulosus neurogenic locus notch protein 4 0.0021 0.0212 0.0265
Plasmodium falciparum hexose transporter 0.0221 0.4543 0.4441
Onchocerca volvulus 0.0031 0.044 0.0536
Schistosoma mansoni cell polarity protein 0.0021 0.0212 0.0466
Trichomonas vaginalis glucose transporter, putative 0.0069 0.1249 0.1329
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.044 0.0261
Schistosoma mansoni hypothetical protein 0.0021 0.0212 0.0466
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0307 0.0459
Onchocerca volvulus 0.0021 0.0212 0.0258
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.044 0.0508
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0507 0.0635
Echinococcus multilocularis calpain A 0.0072 0.1319 0.1654
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.044 0.032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Echinococcus multilocularis General substrate transporter 0.019 0.3872 0.4854
Schistosoma mansoni glucose transport protein 0.0221 0.4543 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Onchocerca volvulus 0.0032 0.0465 0.0567
Schistosoma mansoni tyrosine kinase 0.0032 0.0465 0.1025
Schistosoma mansoni protein kinase 0.0034 0.0507 0.1115
Toxoplasma gondii facilitative glucose transporter GT1 0.0221 0.4543 0.6816
Loa Loa (eye worm) hypothetical protein 0.0048 0.0805 0.0981
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0391 0.8206 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0207 0.026
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0161 0.3253 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Loa Loa (eye worm) glutamate receptor 1 0.0063 0.1128 0.1375
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0307 0.0875
Brugia malayi Cadherin domain containing protein 0.0021 0.0212 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.2369 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.044 0.0473
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0391 0.8206 1
Brugia malayi hypothetical protein 0.0031 0.044 0.0536
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Loa Loa (eye worm) hypothetical protein 0.0048 0.0805 0.0981
Trichomonas vaginalis sugar transporter, putative 0.0069 0.1249 0.1329
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0343 0.0199
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0343 0.0628
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0307 0.0345
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Echinococcus granulosus glutamate receptor 2 0.0095 0.1825 0.2288
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0816 0.0994
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.091 0.1109
Plasmodium vivax calpain, putative 0.002 0.0207 0.0025
Brugia malayi hypothetical protein 0.0031 0.044 0.0536
Echinococcus granulosus delta-like protein 1 0.0021 0.0212 0.0265
Echinococcus multilocularis solute carrier family 22 0.0031 0.044 0.0552
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0391 0.8206 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Echinococcus granulosus protein jagged 1 0.0021 0.0212 0.0265
Schistosoma mansoni protein kinase 0.0034 0.0507 0.1115
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Schistosoma mansoni hypothetical protein 0.0021 0.0212 0.0466
Brugia malayi EGF-like domain containing protein 0.0021 0.0212 0.0258
Loa Loa (eye worm) calpain 5 0.002 0.0207 0.0253
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0032 0.0465 0.0584
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0063 0.1128 0.1414
Echinococcus granulosus calpain 7 C02 family 0.002 0.0207 0.026
Trypanosoma brucei glucose transporter, putative 0.0069 0.1249 0.4819
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1109
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0173 0.3501 0.439
Chlamydia trachomatis glutamine binding protein 0.0161 0.3253 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.044 0.0552
Loa Loa (eye worm) calpain 0.002 0.0207 0.0253
Loa Loa (eye worm) blistered cuticle protein 3 0.0063 0.114 0.1389
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0032 0.0465 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.1249 0.1329
Echinococcus granulosus peroxidasin 0.0063 0.114 0.1429
Schistosoma mansoni hypothetical protein 0.0021 0.0212 0.0466
Echinococcus granulosus solute carrier family 22 0.0031 0.044 0.0552
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0161 0.3253 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Schistosoma mansoni septate junction protein 0.0021 0.0212 0.0466
Brugia malayi Glutamate receptor 1 precursor 0.0063 0.1128 0.1375
Echinococcus granulosus notch 0.0021 0.0212 0.0265
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0343 0.0199
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0507 0.0403
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0343 0.0628
Echinococcus multilocularis neural cadherin 0.0021 0.0212 0.0265
Onchocerca volvulus 0.0031 0.044 0.0536
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0507 0.033
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0095 0.1825 0.2288
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.044 0.0552
Onchocerca volvulus Dual oxidase homolog 0.0063 0.114 0.1389
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Echinococcus multilocularis glutamate receptor 2 0.0063 0.1128 0.1414
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0236 0.4873 0.5939
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.044 0.0401
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.1249 0.4819
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0212 0.0258
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0612 0.1869
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0507 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0507 0.0618
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0226 0.0078
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0307 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0816 0.0994
Schistosoma mansoni glutamate receptor kainate 0.0063 0.1128 0.2483
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.1249 0.4819
Trichomonas vaginalis glucose transporter, putative 0.0031 0.044 0.032
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Brugia malayi major facilitator superfamily protein 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Echinococcus multilocularis peroxidasin 0.0063 0.114 0.1429
Onchocerca volvulus Peroxidase homolog 0.0063 0.114 0.1389
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Brugia malayi Sugar transporter family protein 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.0536
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0236 0.4873 0.611
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0307 0.3999
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Loa Loa (eye worm) hypothetical protein 0.0068 0.1244 0.1515
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.091 0.1109
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0212 0.0265
Schistosoma mansoni glutamate receptor NMDA 0.0063 0.1128 0.2483
Schistosoma mansoni hypothetical protein 0.0036 0.0549 0.1208
Loa Loa (eye worm) glutamate receptor 2 0.0063 0.1128 0.1375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Loa Loa (eye worm) hypothetical protein 0.0191 0.3902 0.4755
Schistosoma mansoni hypothetical protein 0.0021 0.0212 0.0466
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0612 0.0436
Onchocerca volvulus 0.0031 0.044 0.0536
Echinococcus granulosus calpain A 0.002 0.0207 0.026
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0307 0.0675
Loa Loa (eye worm) hypothetical protein 0.0033 0.0492 0.0599
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trypanosoma cruzi hexose transporter, putative 0.0069 0.1249 0.4819
Echinococcus multilocularis calpain family protein 1, d 0.0048 0.0805 0.1009
Schistosoma mansoni hypothetical protein 0.0021 0.0212 0.0466
Loa Loa (eye worm) hypothetical protein 0.0063 0.114 0.1389
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0343 0.0199
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0492 0.0385
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0507 0.0618
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0027 0.0343 0.043
Onchocerca volvulus 0.0031 0.044 0.0536
Loa Loa (eye worm) hypothetical protein 0.0025 0.0307 0.0374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0258
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0032 0.0465 0.0584
Trichomonas vaginalis sugar transporter, putative 0.0069 0.1249 0.1329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0816 0.1023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.013 0.0158
Trichomonas vaginalis sugar transporter, putative 0.0031 0.044 0.032
Brugia malayi Latrophilin receptor protein 2 0.0017 0.013 0.0158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0567
Echinococcus granulosus solute carrier family 22 0.0031 0.044 0.0552
Onchocerca volvulus 0.0031 0.044 0.0536
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0065 0.008
Brugia malayi Muscle positioning protein 4 0.0021 0.0212 0.0258
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0072 0.1319 0.1654
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.4543 0.5696
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0307 0.0374
Echinococcus granulosus glutamate NMDA receptor subunit 0.0063 0.1128 0.1414
Brugia malayi Metabotropic glutamate receptor precursor. 0.0032 0.0465 0.0567

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.6 uM IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines. ChEMBL. 10197959
IC50 (binding) = 1.6 uM IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines. ChEMBL. 10197959
IC50 (binding) = 2.7 uM IC50 against recombinant human Prostaglandin G/H synthase 2 ChEMBL. 10197959
IC50 (binding) = 2.7 uM IC50 against recombinant human Prostaglandin G/H synthase 2 ChEMBL. 10197959
IC50 (binding) > 20 uM IC50 value was determined against Prostaglandin G/H synthase 1 of human platelet rich plasma; Not active ChEMBL. 10197959
IC50 (binding) > 20 uM IC50 value was determined against Prostaglandin G/H synthase 1 of human platelet rich plasma; Not active ChEMBL. 10197959
Inhibition (binding) < 20 % IC50 value of the compound was tested against ovine Prostaglandin G/H synthase 1; Not active ChEMBL. 10197959
Inhibition (binding) < 20 % IC50 value of the compound was tested against ovine Prostaglandin G/H synthase 1; Not active ChEMBL. 10197959

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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