Detailed information for compound 1656205

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 562.918 | Formula: C27H30Cl3N5O2
  • H donors: 2 H acceptors: 3 LogP: 6.28 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)N[C@H]1CCCN(C1)C(=O)NC(C)(C)C
  • InChi: 1S/C27H30Cl3N5O2/c1-16-23(25(36)31-20-6-5-13-34(15-20)26(37)32-27(2,3)4)33-35(22-12-11-19(29)14-21(22)30)24(16)17-7-9-18(28)10-8-17/h7-12,14,20H,5-6,13,15H2,1-4H3,(H,31,36)(H,32,37)/t20-/m0/s1
  • InChiKey: LWZGXMGCJIJOAX-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0854 0.5129 0.5724
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0192 0.0279
Loa Loa (eye worm) hypothetical protein 0.0566 0.3372 0.3716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1129 0.1241
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0176 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0025
Brugia malayi Sodium:solute symporter family protein 0.004 0.017 0.017
Brugia malayi beta-lactamase family protein 0.004 0.0176 0.0175
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0051 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0176 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.1272 0.7672 0.8591
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1129 0.1241
Schistosoma mansoni inositol transporter 0.004 0.017 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0025
Echinococcus granulosus solute carrier family 5 0.004 0.017 0.0181
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0515 0.0562
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0176 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0176 0.086
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0102 0.5
Schistosoma mansoni hypothetical protein 0.0096 0.0515 0.0562
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0117 0.0122
Echinococcus multilocularis lysosome membrane protein 2 0.1498 0.9044 0.9043
Schistosoma mansoni high-affinity choline transporter 0.0359 0.2115 0.2333
Trichomonas vaginalis glucosylceramidase, putative 0.1272 0.7672 0.8591
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0176 0.086
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0176 0.0169
Loa Loa (eye worm) Smad1 0.0032 0.0126 0.0121
Echinococcus multilocularis CD36 class B scavenger receptor 0.1498 0.9044 0.9043
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0051 0.0049
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0192 0.0279
Mycobacterium ulcerans hypothetical protein 0.004 0.0176 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0126 0.0132
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0126 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0037
Onchocerca volvulus 0.004 0.0176 0.0175
Schistosoma mansoni DNA polymerase eta 0.002 0.0051 0.0049
Trichomonas vaginalis esterase, putative 0.004 0.0176 0.0141
Onchocerca volvulus 0.004 0.017 0.017
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0176 0.086
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0175
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.017 0.0181
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0 0.5
Schistosoma mansoni Smad4 0.0032 0.0126 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0102 0.0198
Brugia malayi N-terminal motif family protein 0.0174 0.0991 0.1078
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.017 0.0164
Echinococcus granulosus high affinity choline transporter 1 0.0359 0.2115 0.2333
Brugia malayi MH2 domain containing protein 0.0032 0.0126 0.0121
Brugia malayi MH1 domain containing protein 0.0018 0.0038 0.0023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0515 0.0551
Entamoeba histolytica hypothetical protein 0.0106 0.0577 0.1035
Schistosoma mansoni Smad4 0.0014 0.0017 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0122
Schistosoma mansoni hypothetical protein 0.0096 0.0515 0.0562
Trichomonas vaginalis glucosylceramidase, putative 0.1477 0.8921 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.1779 0.1952
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0156 0.0305
Schistosoma mansoni hypothetical protein 0.0096 0.0515 0.0562
Echinococcus multilocularis dna polymerase eta 0.002 0.0051 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1129 0.1123
Schistosoma mansoni kinase 0.0434 0.2572 0.2838
Trichomonas vaginalis glucosylceramidase, putative 0.0879 0.528 0.5896
Trichomonas vaginalis CAMK family protein kinase 0.0423 0.2503 0.2765
Loa Loa (eye worm) hypothetical protein 0.0359 0.2115 0.2324
Brugia malayi hypothetical protein 0.0028 0.0102 0.0094
Loa Loa (eye worm) hypothetical protein 0.0096 0.0515 0.0551
Echinococcus granulosus CD36 class B scavenger receptor 0.1498 0.9044 1
Trichomonas vaginalis glucosylceramidase, putative 0.1272 0.7672 0.8591
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0854 0.5129 0.5663
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.0099
Mycobacterium leprae conserved hypothetical protein 0.004 0.0176 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0304 0.1779 0.1952
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0175
Brugia malayi MH2 domain containing protein 0.0032 0.0126 0.0121
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0854 0.5129 1
Trypanosoma brucei unspecified product 0.002 0.0051 0.0099
Brugia malayi Pre-SET motif family protein 0.0031 0.0117 0.0111
Schistosoma mansoni Smad4 0.0014 0.0017 0.0012
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0515 0.0551
Echinococcus multilocularis mothers against decapentaplegic 6 0.0014 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0515 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Echinococcus granulosus dna polymerase eta 0.002 0.0051 0.0049
Echinococcus granulosus smad 0.0032 0.0126 0.0132
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0854 0.5129 0.5668
Brugia malayi Calcitonin receptor-like protein seb-1 0.0304 0.1779 0.1952
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0304 0.1779 0.1952
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0051 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.1272 0.7672 0.8591
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0192 0.0186
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0854 0.5129 0.5724
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0111
Trypanosoma cruzi polo-like protein kinase, putative 0.0854 0.5129 1
Trichomonas vaginalis CAMK family protein kinase 0.0854 0.5129 0.5724
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0175
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0102 0.5
Trichomonas vaginalis set domain proteins, putative 0.0245 0.142 0.1544
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0192 0.0194
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0175
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0175
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0102 0.0198
Loa Loa (eye worm) pax transcription factor protein 2 0.0483 0.2868 0.3158
Trichomonas vaginalis rotamase, putative 0.0038 0.0162 0.0125
Brugia malayi beta-lactamase 0.004 0.0176 0.0175
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0192 0.0205
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.011 0.0115
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0156 0.0305
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.017 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0176 0.0141
Schistosoma mansoni CD36-like class B scavenger receptor 0.1498 0.9044 1
Brugia malayi GH02984p 0.0359 0.2115 0.2324
Echinococcus granulosus geminin 0.0531 0.3161 0.349
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0192 0.0186
Loa Loa (eye worm) beta-lactamase 0.004 0.0176 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.1477 0.8921 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0051 0.0044
Schistosoma mansoni smad1 5 8 and 0.0032 0.0126 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0474 0.2817 0.3101
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1477 0.8921 0.9864
Leishmania major DNA polymerase kappa, putative 0.002 0.0051 0.0099
Plasmodium vivax hypothetical protein, conserved 0.004 0.0176 1
Trichomonas vaginalis glucosylceramidase, putative 0.1477 0.8921 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0577 0.0631
Schistosoma mansoni hypothetical protein 0.0106 0.0577 0.0631
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0051 0.0099
Schistosoma mansoni hypothetical protein 0.0531 0.3161 0.349
Trichomonas vaginalis glucosylceramidase, putative 0.1477 0.8921 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0192 0.016
Brugia malayi beta-lactamase family protein 0.004 0.0176 0.0175
Echinococcus multilocularis solute carrier family 5 0.004 0.017 0.0164
Brugia malayi hypothetical protein 0.0566 0.3372 0.3716
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0117 0.0122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.1129 0.1231
Echinococcus granulosus dna polymerase kappa 0.002 0.0051 0.0049
Brugia malayi CD36 family protein 0.1498 0.9044 1
Loa Loa (eye worm) nuclear factor I 0.0018 0.0038 0.0023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0854 0.5129 0.5125
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0051 0.0037
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0117 0.6676
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0176 0.086
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0176 0.0141
Brugia malayi MH1 domain containing protein 0.0018 0.0038 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0051 0.0049
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.1498 0.9044 1
Trichomonas vaginalis rotamase, putative 0.0037 0.0156 0.0119
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0156 0.8893
Echinococcus multilocularis CD36 class B scavenger receptor 0.1498 0.9044 0.9043
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0192 0.016
Echinococcus granulosus CD36 class B scavenger receptor 0.1498 0.9044 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0192 0.0375
Echinococcus granulosus GPCR family 2 0.0096 0.0515 0.0562
Brugia malayi hypothetical protein 0.0566 0.3372 0.3716
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0176 0.0141
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.1272 0.7672 0.8591
Onchocerca volvulus Serine\/threonine kinase homolog 0.0854 0.5129 0.5663
Echinococcus granulosus CD36 class B scavenger receptor 0.1498 0.9044 1
Trichomonas vaginalis glucosylceramidase, putative 0.1272 0.7672 0.8591
Echinococcus multilocularis geminin 0.0531 0.3161 0.3156
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0162 0.0125
Echinococcus multilocularis GPCR, family 2 0.0096 0.0515 0.0508
Brugia malayi latrophilin 2 splice variant baaae 0.0208 0.1194 0.1303
Entamoeba histolytica hypothetical protein 0.0106 0.0577 0.1035
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0175
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1239 0.1354
Schistosoma mansoni hypothetical protein 0.0531 0.3161 0.349
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.1129 0.1231
Mycobacterium ulcerans beta-lactamase 0.004 0.0176 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Brugia malayi Pre-SET motif family protein 0.0215 0.1239 0.1354
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0156 0.0208
Echinococcus granulosus mothers against decapentaplegic 6 0.0014 0.0017 0.0012
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0176 0.0187
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0156 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1129 0.1241
Loa Loa (eye worm) hypothetical protein 0.0566 0.3372 0.3716
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Echinococcus granulosus CD36 class B scavenger receptor 0.1498 0.9044 1
Toxoplasma gondii ABC1 family protein 0.004 0.0176 1
Onchocerca volvulus Glucosylceramidase homolog 0.1272 0.7672 0.848
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.0099
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0126 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.1272 0.7672 0.8591
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Trypanosoma brucei polo-like protein kinase 0.0854 0.5129 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0102 0.0094
Trypanosoma cruzi polo-like protein kinase, putative 0.0854 0.5129 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1129 0.1123
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0192 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0023
Echinococcus granulosus CD36 class B scavenger receptor 0.1498 0.9044 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0854 0.5129 1
Trichomonas vaginalis CAMK family protein kinase 0.0854 0.5129 0.5724
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.017 0.9705
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0102 0.5795
Echinococcus multilocularis CD36 class B scavenger receptor 0.1498 0.9044 0.9043
Brugia malayi hypothetical protein 0.0106 0.0577 0.062
Schistosoma mansoni hypothetical protein 0.0096 0.0515 0.0562
Schistosoma mansoni cd36 antigen 0.0566 0.3372 0.3724
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.0099
Schistosoma mansoni smad 0.0014 0.0017 0.0012
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.017 0.0164
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.0991 0.1078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0515 0.0508
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0192 0.0205
Schistosoma mansoni CD36-like class B scavenger receptor 0.1498 0.9044 1
Trichomonas vaginalis CAMK family protein kinase 0.0854 0.5129 0.5724
Mycobacterium leprae Probable lipase LipE 0.004 0.0176 0.5
Schistosoma mansoni inositol transporter 0.004 0.017 0.0181
Loa Loa (eye worm) transcription factor SMAD2 0.0474 0.2817 0.3101
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.0099
Brugia malayi Pax transcription factor protein 2 0.0483 0.2868 0.3158
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0117 0.0111
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0051 0.0099
Echinococcus multilocularis smad 0.0032 0.0126 0.0119
Loa Loa (eye worm) hypothetical protein 0.1498 0.9044 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0156 0.0305
Mycobacterium tuberculosis Conserved protein 0.004 0.0176 0.086
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0176 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Echinococcus multilocularis Smad4 0.0032 0.0126 0.0119
Loa Loa (eye worm) hypothetical protein 0.0208 0.1194 0.1303
Echinococcus multilocularis mothers against decapentaplegic 2 0.0014 0.0017 0.0011
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.1498 0.9044 1
Echinococcus multilocularis high affinity choline transporter 1 0.0359 0.2115 0.211
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0176 0.0342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1129 0.1241
Leishmania major hypothetical protein, conserved 0.004 0.0176 0.0342
Schistosoma mansoni sodium/solute symporter 0.004 0.017 0.0181
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.1503 1
Echinococcus granulosus lysosome membrane protein 2 0.1498 0.9044 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.1498 0.9044 0.9043
Schistosoma mansoni hypothetical protein 0.0208 0.1194 0.1313
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0192 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0879 0.528 0.5896
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0577 0.057
Loa Loa (eye worm) hypothetical protein 0.1498 0.9044 1
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0176 0.086
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0515 0.0508
Mycobacterium tuberculosis Conserved protein 0.004 0.0176 0.086
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0025
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.0099
Onchocerca volvulus 0.004 0.0176 0.0175
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0051 0.0049
Echinococcus multilocularis expressed protein 0.0038 0.0162 0.0155
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0126 0.0132
Giardia lamblia Kinase, PLK 0.0854 0.5129 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0176 0.086
Entamoeba histolytica hypothetical protein 0.0106 0.0577 0.1035
Schistosoma mansoni smad1 5 8 and 0.0032 0.0126 0.0132
Schistosoma mansoni smad 0.0032 0.0126 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0176 0.0342
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0176 0.086
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0176 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1129 0.1241
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0051 0.0037
Brugia malayi Smad1 0.0032 0.0126 0.0121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0176 0.0187
Echinococcus granulosus Smad4 0.0032 0.0126 0.0132
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.017 0.0181
Brugia malayi MH1 domain containing protein 0.0032 0.0126 0.0121
Mycobacterium tuberculosis Conserved protein 0.004 0.0176 0.086
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1477 0.8921 0.9864
Loa Loa (eye worm) hypothetical protein 0.0566 0.3372 0.3716
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.017 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0854 0.5129 0.5668
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0192 0.0186
Onchocerca volvulus 0.0483 0.2868 0.3158
Brugia malayi MH2 domain containing protein 0.0474 0.2817 0.3101
Brugia malayi MH1 domain containing protein 0.0032 0.0126 0.0121
Echinococcus granulosus mothers against decapentaplegic 2 0.0014 0.0017 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0176 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0126 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.0099
Leishmania major DNA polymerase eta, putative 0.002 0.0051 0.0099
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0577 0.0631
Mycobacterium ulcerans lipase LipD 0.004 0.0176 1
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0192 0.0205
Echinococcus granulosus expressed protein 0.0038 0.0162 0.0171
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.1477 0.8921 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0192 0.0375
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0051 0.0037
Onchocerca volvulus 0.0245 0.142 0.1554
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0162 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0854 0.5129 0.5724
Echinococcus multilocularis CD36 class B scavenger receptor 0.1498 0.9044 0.9043
Leishmania major hypothetical protein, conserved 0.0028 0.0102 0.0198
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0102 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0854 0.5129 0.5724
Schistosoma mansoni rotamase 0.0038 0.0162 0.0171
Loa Loa (eye worm) hypothetical protein 0.1498 0.9044 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.017 0.0181
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0162 0.016
Brugia malayi serine/threonine-protein kinase plk-2 0.0854 0.5129 0.5663
Loa Loa (eye worm) hypothetical protein 0.0043 0.0192 0.0194
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0176 0.0175
Onchocerca volvulus 0.004 0.0176 0.0175
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0515 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0423 0.2503 0.2765
Plasmodium vivax SET domain protein, putative 0.0031 0.0117 0.2095
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0126 0.0119
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0192 0.0375
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0192 0.0375
Schistosoma mansoni smad1 5 8 and 0.0032 0.0126 0.0132
Brugia malayi hypothetical protein 0.0018 0.0041 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0176 0.0187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0117 0.0111
Entamoeba histolytica hypothetical protein 0.0106 0.0577 0.1035
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0192 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.1477 0.8921 1
Onchocerca volvulus 0.0031 0.0117 0.0111
Loa Loa (eye worm) hypothetical protein 0.0174 0.0991 0.1078

Activities

Activity type Activity value Assay description Source Reference
Ke (functional) = 206 nM Antagonist activity at human CB1 receptor expressed in CHO-K1 cells co-expressing Galphaq16 assessed as inhibition of CP55940-induced intracellular calcium mobilization by fluorometry ChEMBL. 22372835

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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