Detailed information for compound 1656697

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 229.342 | Formula: C10H19N3OS
  • H donors: 3 H acceptors: 1 LogP: 0.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCCC[C@@H]1SC[C@H]2[C@@H]1NC(=O)N2
  • InChi: 1S/C10H19N3OS/c11-5-3-1-2-4-8-9-7(6-15-8)12-10(14)13-9/h7-9H,1-6,11H2,(H2,12,13,14)/t7-,8-,9-/m0/s1
  • InChiKey: WRWZCIJUQQONIV-CIUDSAMLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0158 0.0145
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0013 0.0016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0129 0.1534
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Onchocerca volvulus Lipoyltransferase 1, mitochondrial homolog 0.0015 0.0013 0.006
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0613 0.0724
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Trichomonas vaginalis tubulin epsilon chain, putative 0.0018 0.0038 0.0036
Brugia malayi LBP/BPI 0.0015 0.0016 0.002
Loa Loa (eye worm) tubulin alpha-2 chain 0.0018 0.0038 0.0049
Echinococcus multilocularis GPCR, family 2 0.0031 0.0155 0.0183
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0193 0.0191
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0222 0.1782 0.2105
Schistosoma mansoni hypothetical protein 0.0035 0.0187 0.0286
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.002 0.006 0.0078
Brugia malayi hypothetical protein 0.0064 0.0435 0.0578
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0317 0.9971
Schistosoma mansoni jun-related protein 0.007 0.0483 0.0739
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0049
Schistosoma mansoni hypothetical protein 0.0031 0.0155 0.0237
Entamoeba histolytica recQ family DNA helicase 0.0014 0.0011 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.073 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.1183 1 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0129 0.0153
Loa Loa (eye worm) hypothetical protein 0.0341 0.2805 0.3737
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.0189 0.0249
Brugia malayi lipoate-protein ligase B containing protein 0.0015 0.0013 0.0015
Trypanosoma brucei protein kinase, putative 0.005 0.0317 0.9975
Schistosoma mansoni tubulin subunit alpha 0.0018 0.0038 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0149 0.0228
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0013 0.0016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0129 0.1534
Onchocerca volvulus 0.0035 0.0189 0.0993
Echinococcus granulosus tubulin alpha 1C chain 0.0018 0.0038 0.0045
Echinococcus granulosus tubulin alpha chain 0.0018 0.0038 0.0045
Mycobacterium leprae POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS 0.0036 0.0194 0.0444
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0317 0.0421
Entamoeba histolytica hypothetical protein 0.0035 0.0187 0.0454
Plasmodium vivax SET domain protein, putative 0.003 0.0149 0.382
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0129 0.017
Echinococcus granulosus cpg binding protein 0.0058 0.0382 0.0451
Toxoplasma gondii alpha-tubulin I, putative 0.0018 0.0038 0.035
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0317 0.0316
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0317 0.0375
Schistosoma mansoni loxhd1 0.0057 0.0379 0.058
Plasmodium falciparum LCCL domain-containing protein 0.0057 0.0379 1
Trypanosoma brucei Biotin--acetyl-CoA-carboxylase ligase, putative 0.005 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0155 0.0204
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0151 0.4724
Echinococcus granulosus activated cdc42 kinase 1 0.0891 0.7503 0.8862
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0414 0.0549
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.0191
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0317 0.9975
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0015
Plasmodium vivax tubulin alpha chain, putative 0.0018 0.0038 0.0849
Echinococcus granulosus bloom syndrome protein 0.0041 0.0235 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0149 0.0228
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0129 0.0153
Trypanosoma cruzi lipoate-protein ligase, putative 0.0015 0.0013 0.0357
Echinococcus multilocularis biotin protein ligase 0.005 0.0318 0.0376
Brugia malayi Doublecortin family protein 0.0057 0.0379 0.0503
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1884 0.1883
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0158 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0414 0.0633
Chlamydia trachomatis sulfate transporter 0.0032 0.0158 0.3145
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0158 0.4942
Loa Loa (eye worm) glutaminase 2 0.0269 0.219 0.2918
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0317 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0016 0.0015
Brugia malayi Tubulin alpha-2 chain 0.0018 0.0038 0.0049
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Mycobacterium ulcerans integral membrane transporter 0.0032 0.0158 0.0145
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0013
Brugia malayi Tubulin alpha-2 chain 0.0018 0.0038 0.0049
Echinococcus granulosus tumor protein p63 0.1004 0.8467 1
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Brugia malayi biotin--acetyl-CoA-carboxylase ligase family protein 0.005 0.0318 0.0422
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Echinococcus multilocularis tumor protein p63 0.1004 0.8467 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0414 0.0633
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0193 0.2357
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1643 0.2188
Schistosoma mansoni alpha tubulin 0.0018 0.0038 0.0058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.002
Schistosoma mansoni cpg binding protein 0.0055 0.0355 0.0543
Mycobacterium ulcerans hypothetical protein 0.0105 0.0789 0.0777
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0013 0.0016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0193 0.0469
Onchocerca volvulus 0.0055 0.0355 0.1877
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0129 0.0153
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0317 0.9975
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0268 0.0355
Loa Loa (eye worm) alpha-tubulin 0.0018 0.0038 0.0049
Brugia malayi alpha-tubulin 0.0018 0.0038 0.0049
Echinococcus multilocularis Tubulin alpha 1 chain 0.0018 0.0038 0.0045
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0317 0.0774
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0414 0.0633
Toxoplasma gondii histone lysine methyltransferase SET1 0.0105 0.0782 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0193 0.6036
Trichomonas vaginalis tubulin beta chain, putative 0.0018 0.0038 0.0036
Onchocerca volvulus 0.0234 0.1884 1
Onchocerca volvulus Putative lipoyltransferase 2, mitochondrial 0.0015 0.0013 0.006
Trichomonas vaginalis glutaminase, putative 0.0269 0.219 0.2189
Echinococcus granulosus Polycystic kidney disease protein 0.0057 0.0379 0.0447
Leishmania major biotin/lipoate protein ligase-like protein 0.005 0.0318 0.0776
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0464 0.0616
Brugia malayi hypothetical protein 0.0057 0.0379 0.0503
Schistosoma mansoni rab6-interacting 0.0057 0.0379 0.058
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Trichomonas vaginalis tubulin beta chain, putative 0.0018 0.0038 0.0036
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0112 0.0171
Echinococcus multilocularis Tubulin alpha 1 chain 0.0018 0.0038 0.0045
Echinococcus multilocularis N terminal of biotin protein ligase 0.0069 0.0474 0.056
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0129 0.3181
Brugia malayi MAP kinase sur-1 0.005 0.0317 0.0421
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0235 0.0277
Entamoeba histolytica hypothetical protein 0.0035 0.0187 0.0454
Loa Loa (eye worm) hypothetical protein 0.0036 0.0194 0.0256
Echinococcus multilocularis jun protein 0.0085 0.0613 0.0724
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0251 0.2034 0.2545
Schistosoma mansoni tubulin subunit alpha 0.0018 0.0038 0.0058
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0158 0.4942
Loa Loa (eye worm) hypothetical protein 0.0341 0.2805 0.3737
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.0189 0.0249
Echinococcus granulosus dnaJ subfamily B 0.0778 0.6535 0.7718
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0117 0.2831
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.009 0.1026
Loa Loa (eye worm) doublecortin family protein 0.0057 0.0379 0.0503
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0155 0.0204
Schistosoma mansoni hypothetical protein 0.0031 0.0155 0.0237
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0117 0.2831
Plasmodium vivax tubulin alpha chain, putative 0.0018 0.0038 0.0849
Schistosoma mansoni lipoxygenase 0.0222 0.1782 0.2727
Echinococcus granulosus tubulin alpha 3 chain 0.0018 0.0038 0.0045
Onchocerca volvulus Putative sulfate transporter 0.0198 0.1582 0.8395
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0129 0.3258
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0346 0.2844 0.3359
Giardia lamblia Hypothetical protein 0.005 0.0318 1
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.126 0.1678
Onchocerca volvulus 0.0035 0.0189 0.0993
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0149 0.0176
Echinococcus multilocularis Polycystic kidney disease protein 0.0057 0.0379 0.0447
Onchocerca volvulus 0.0064 0.0435 0.2303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0268 0.041
Echinococcus granulosus octanoyltransferase mitochondrial 0.0015 0.0013 0.0015
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0235 0.0311
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0222 0.1782 0.2105
Trichomonas vaginalis tubulin beta chain, putative 0.0018 0.0038 0.0036
Schistosoma mansoni cpg binding protein 0.0058 0.0382 0.0584
Trichomonas vaginalis lipoate-protein ligase, putative 0.0015 0.0013 0.0011
Onchocerca volvulus 0.0035 0.0189 0.0993
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0155 0.0183
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0129 0.017
Schistosoma mansoni alpha tubulin 0.0018 0.0038 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0249
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0187 0.0286
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0129 0.0153
Loa Loa (eye worm) hypothetical protein 0.0067 0.0464 0.0616
Echinococcus granulosus tubulin alpha chain 0.0018 0.0038 0.0045
Echinococcus multilocularis lipoxygenase domain containing protein 0.0057 0.0379 0.0447
Onchocerca volvulus 0.0015 0.0016 0.0078
Echinococcus multilocularis lipoxygenase domain containing protein 0.0057 0.0379 0.0447
Loa Loa (eye worm) tubulin alpha 2 0.0013 0.0003 0.0002
Echinococcus multilocularis tubulin alpha chain 0.0018 0.0038 0.0045
Brugia malayi lipoate-protein ligase, mitochondrial precursor, putative 0.0015 0.0013 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0317 0.0486
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0414 0.0633
Schistosoma mansoni biotin-protein ligase 0.005 0.0318 0.0487
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0158 0.4942
Schistosoma mansoni hypothetical protein 0.0031 0.0155 0.0237
Echinococcus granulosus lipoxygenase domain containing protein 0.0057 0.0379 0.0447
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0117 0.363
Loa Loa (eye worm) hypothetical protein 0.0057 0.0379 0.0503
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0317 0.0316
Trichomonas vaginalis tubulin epsilon chain, putative 0.0018 0.0038 0.0036
Wolbachia endosymbiont of Brugia malayi biotin-(acetyl-CoA carboxylase) ligase 0.005 0.0318 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0151 0.4724
Brugia malayi glutaminase DH11.1 0.0269 0.219 0.2918
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0268 0.041
Onchocerca volvulus 0.0035 0.0189 0.0993
Schistosoma mansoni hypothetical protein 0.0031 0.0155 0.0237
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.002
Echinococcus granulosus jun protein 0.0085 0.0613 0.0724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0194 0.0256
Trypanosoma brucei alpha tubulin 0.0018 0.0038 0.1151
Echinococcus granulosus tubulin alpha chain 0.0018 0.0038 0.0045
Trypanosoma brucei alpha tubulin 0.0018 0.0038 0.1151
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0317 0.0316
Treponema pallidum biotin--acetyl-CoA-carboxylase ligase 0.0229 0.1844 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0117 0.0153
Onchocerca volvulus 0.0057 0.0379 0.2003
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0317 0.9975
Echinococcus granulosus tubulin alpha 3 chain 0.0018 0.0038 0.0045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0149 0.1786
Echinococcus granulosus lipoxygenase domain containing protein 0.0057 0.0379 0.0447
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0042 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0042 0.005
Echinococcus granulosus neuropeptide s receptor 0.0456 0.3783 0.4468
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0149 0.0176
Schistosoma mansoni tubulin subunit alpha 0.0018 0.0038 0.0058
Trypanosoma cruzi alpha tubulin, putative 0.0018 0.0038 0.1151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0268 0.0316
Echinococcus granulosus microtubule associated protein 2 0.068 0.57 0.6732
Schistosoma mansoni alpha-glucosidase 0.0138 0.1069 0.1636
Onchocerca volvulus 0.0057 0.0379 0.2003
Schistosoma mansoni cpg binding protein 0.0058 0.0382 0.0584
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Brugia malayi tubulin alpha chain - mouse 0.0018 0.0038 0.0049
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.126 0.1489
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0404 0.0403
Onchocerca volvulus 0.0035 0.0189 0.0993
Chlamydia trachomatis biotin synthetase 0.005 0.0318 0.6615
Entamoeba histolytica tubulin alpha chain, putative 0.0018 0.0038 0.0089
Schistosoma mansoni alpha tubulin 0.0018 0.0038 0.0058
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0193 0.0191
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.1144 0.1751
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0151 0.015
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0158 0.1907
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0078
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.3783 0.4468
Plasmodium vivax lipoate-protein ligase 1, putative 0.0015 0.0013 0.0174
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0013 0.0003 0.0002
Loa Loa (eye worm) tubulin alpha chain 0.0018 0.0038 0.0049
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0404 0.0536
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0078
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0229 0.1845 0.2306
Echinococcus multilocularis protein KINase family member (kin 25) 0.0346 0.2844 0.3359
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0268 0.041
Echinococcus multilocularis Tubulin alpha 1 chain 0.0018 0.0038 0.0045
Echinococcus granulosus N terminal of biotin protein ligase 0.0069 0.0474 0.056
Brugia malayi tubulin alpha-2 chain 0.0018 0.0038 0.0049
Brugia malayi hypothetical protein 0.0035 0.0187 0.0247
Schistosoma mansoni lipoate-protein ligase B 0.0015 0.0013 0.002
Brugia malayi Protein kinase domain containing protein 0.0891 0.7503 1
Loa Loa (eye worm) RecQ helicase 0.0041 0.0235 0.0311
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0158 0.3967
Entamoeba histolytica hypothetical protein 0.0035 0.0187 0.0454
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0268 0.0316
Loa Loa (eye worm) hypothetical protein 0.0057 0.0379 0.0503
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0268 0.0316
Schistosoma mansoni hypothetical protein 0.006 0.0404 0.0619
Mycobacterium ulcerans bifunctional protein BirA 0.0214 0.172 0.1709
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.073 0.0971
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0078
Plasmodium falciparum biotin--acetyl-CoA-carboxylase, putative 0.005 0.0318 0.8343
Mycobacterium tuberculosis Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas 0.0036 0.0194 0.0227
Mycobacterium leprae Probable transmembrane transport protein 0.0229 0.1845 0.4506
Loa Loa (eye worm) hypothetical protein 0.0147 0.1144 0.1523
Trichomonas vaginalis tubulin beta chain, putative 0.0018 0.0038 0.0036
Entamoeba histolytica carbonic anhydrase, putative 0.049 0.4078 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0414 0.0633
Brugia malayi hypothetical protein 0.0015 0.0016 0.002
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0213 0.5469
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.005 0.0318 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0187 0.0221
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0129 0.0153
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.002
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.3783 0.4468
Echinococcus granulosus activated cdc42 kinase 1 0.0891 0.7503 0.8862
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0317 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0149 0.0228
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0317 0.9975
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0193 0.0228
Loa Loa (eye worm) hypothetical protein 0.0079 0.0566 0.0752
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0468 0.3889 0.4879
Schistosoma mansoni hypothetical protein 0.0067 0.0464 0.0709
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0155 0.0183
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.126 0.1678
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.002 0.006 0.0078
Brugia malayi Pre-SET motif family protein 0.0205 0.1643 0.2188
Echinococcus multilocularis tubulin alpha chain 0.0018 0.0038 0.0045
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Echinococcus granulosus Tubulin alpha 1 chain 0.0018 0.0038 0.0045
Leishmania major lipoate-protein ligase-like,lipoyl ligase, putative,lipoyltransferase, putative,lipoate biosynthesis protein, putative 0.0015 0.0013 0.0028
Loa Loa (eye worm) biotin protein ligase 1 0.005 0.0318 0.0422
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.049 0.4078 1
Entamoeba histolytica hypothetical protein 0.0035 0.0187 0.0454
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0613 0.0724
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.6835 0.8073
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.126 0.1489
Loa Loa (eye worm) hypothetical protein 0.0346 0.2844 0.3789
Leishmania major hypothetical protein, conserved 0.0027 0.0117 0.0282
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0155 0.0204
Trypanosoma brucei alpha tubulin 0.0018 0.0038 0.1151
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0193 0.0191
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0035 0.0189 0.0249
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0944 0.7956 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0055 0.0355 0.0471
Echinococcus granulosus 5'partial|biotin protein ligase 0.0036 0.0194 0.0229
Brugia malayi Tubulin alpha chain 0.0018 0.0038 0.0049
Schistosoma mansoni tyrosine kinase 0.0346 0.2844 0.4352
Onchocerca volvulus 0.002 0.006 0.0312
Toxoplasma gondii lipoyl(octanoyl) transferase 0.0015 0.0013 0.0024
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.002 0.006 0.0078
Mycobacterium ulcerans glutaminase 0.0269 0.219 0.218
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0013 0.0021
Schistosoma mansoni blooms syndrome DNA helicase 0.0014 0.0011 0.0017
Onchocerca volvulus 0.003 0.0149 0.0781
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0011 0.03
Schistosoma mansoni DNA helicase recq1 0.0028 0.0129 0.0198
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0018 0.0038 0.0036
Echinococcus multilocularis tubulin alpha 3 chain 0.0018 0.0038 0.0045
Echinococcus multilocularis tubulin subunit TubB 0.0018 0.0038 0.0045
Onchocerca volvulus 0.0035 0.0189 0.0993
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0095 0.2373
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0013 0.0003 0.0001
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0169 0.0411
Trypanosoma brucei lipoyltransferase, putative 0.0015 0.0013 0.0357
Loa Loa (eye worm) hypothetical protein 0.0891 0.7503 1
Echinococcus granulosus tubulin subunit TubB 0.0018 0.0038 0.0045
Schistosoma mansoni alpha-glucosidase 0.0138 0.1069 0.1636
Trypanosoma brucei alpha tubulin 0.0018 0.0038 0.1151
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0117 0.363
Brugia malayi hypothetical protein 0.0017 0.0036 0.0045
Brugia malayi hypothetical protein 0.0057 0.0379 0.0503
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0042 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0268 0.0316
Loa Loa (eye worm) hypothetical protein 0.0027 0.0117 0.0153
Schistosoma mansoni polycystin 1-related 0.0057 0.0379 0.058
Schistosoma mansoni hypothetical protein 0.0778 0.6535 1
Brugia malayi RNA binding protein 0.0061 0.0414 0.0549
Plasmodium vivax biotin--[acetyl-CoA-carboxylase] synthetase, putative 0.005 0.0318 0.8372
Brugia malayi TAR-binding protein 0.0061 0.0414 0.0549
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0169 0.0411
Plasmodium falciparum alpha tubulin 2 0.0018 0.0038 0.0687
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0117 0.363
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0155 0.0183
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0414 0.0549
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0317 0.3975
Brugia malayi CXXC zinc finger family protein 0.0055 0.0355 0.0471
Brugia malayi Pre-SET motif family protein 0.003 0.0149 0.0196
Toxoplasma gondii alpha tubulin TUBA1 0.0018 0.0038 0.035
Echinococcus granulosus Tubulin alpha 1 chain 0.0018 0.0038 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.1183 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0018 0.0038 0.0045
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Echinococcus granulosus tubulin alpha chain 0.0018 0.0038 0.0045
Chlamydia trachomatis hypothetical protein 0.0069 0.0474 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.073 0.0971
Brugia malayi bZIP transcription factor family protein 0.0085 0.0613 0.0815
Schistosoma mansoni DNA helicase recq5 0.0028 0.0129 0.0198
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.3783 0.4468
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0155 0.0183
Mycobacterium ulcerans carbonic anhydrase 0.049 0.4078 0.4071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.073 0.0971
Trichomonas vaginalis tubulin beta chain, putative 0.0018 0.0038 0.0036
Schistosoma mansoni biotin-protein ligase 0.0069 0.0474 0.0726
Entamoeba histolytica tubulin alpha-1 chain 0.0018 0.0038 0.0089
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0414 0.0489
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0007 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.0191
Echinococcus granulosus alpha tubulin 0.0018 0.0038 0.0045
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0129 0.017
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.0191
Echinococcus multilocularis microtubule associated protein 2 0.068 0.57 0.6732
Echinococcus granulosus tubulin alpha chain 0.0018 0.0038 0.0045
Onchocerca volvulus 0.002 0.006 0.0312
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0193 0.0255
Echinococcus multilocularis octanoyltransferase, mitochondrial 0.0015 0.0013 0.0015
Plasmodium falciparum alpha tubulin 1 0.0018 0.0038 0.0687
Onchocerca volvulus 0.0147 0.1144 0.6068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0013 0.0016
Onchocerca volvulus 0.0035 0.0189 0.0993
Echinococcus granulosus RUN 0.0057 0.0379 0.0447
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0193 0.0191
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.002 0.006 0.0078
Plasmodium vivax sulfate transporter, putative 0.0032 0.0158 0.4072
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0117 0.1368
Schistosoma mansoni microtubule-associated protein tau 0.068 0.57 0.8722
Echinococcus multilocularis RUN 0.0057 0.0379 0.0447
Echinococcus multilocularis tubulin alpha 1C chain 0.0018 0.0038 0.0045
Echinococcus multilocularis peroxisome assembly protein 26 0.0018 0.0038 0.0045
Brugia malayi hypothetical protein 0.002 0.006 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0149 0.0176
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0317 0.0375
Echinococcus granulosus peroxisome assembly protein 26 0.0018 0.0038 0.0045
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0193 0.0255
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Loa Loa (eye worm) hypothetical protein 0.0028 0.0129 0.017
Loa Loa (eye worm) tubulin alpha 2 0.0013 0.0003 0.0002
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0193 0.0469
Echinococcus granulosus tar DNA binding protein 0.0061 0.0414 0.0489
Schistosoma mansoni hypothetical protein 0.0057 0.0379 0.058
Trypanosoma cruzi lipoyltransferase, putative 0.0015 0.0013 0.0357
Trichomonas vaginalis tubulin beta chain, putative 0.0018 0.0038 0.0036
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0414 0.0549
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.002
Loa Loa (eye worm) RNA binding protein 0.0061 0.0414 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0149 0.0228
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0404 0.0477
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0235 0.0233
Loa Loa (eye worm) hypothetical protein 0.0887 0.7465 0.9948
Loa Loa (eye worm) alpha-tubulin 0.0018 0.0038 0.0049
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0404 0.0477
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Plasmodium falciparum biotin protein ligase, putative 0.005 0.0318 0.8343
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0193 0.6036
Leishmania major alpha tubulin 0.0018 0.0038 0.0089
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.005 0.0318 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0891 0.7503 0.8862
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0474 0.116
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0151 0.0367
Plasmodium vivax multidomain scavenger receptor, putative 0.0057 0.0379 1
Onchocerca volvulus 0.0093 0.0682 0.3613
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0035 0.0189 0.0249
Echinococcus multilocularis transfer RNA-Thr 0.0891 0.7503 0.8862
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.0191
Echinococcus granulosus GPCR family 2 0.0031 0.0155 0.0183
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.004 0.0051
Onchocerca volvulus 0.0198 0.1582 0.8395
Echinococcus multilocularis dnaJ subfamily B 0.0778 0.6535 0.7718
Echinococcus multilocularis cpg binding protein 0.0058 0.0382 0.0451
Brugia malayi DnaJ domain containing protein 0.006 0.0404 0.0536
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.002 0.006 0.0078
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0317 0.0375
Schistosoma mansoni rab6-interacting 0.0057 0.0379 0.058
Schistosoma mansoni carbonic anhydrase 0.049 0.4078 0.6241
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0155 0.0204
Schistosoma mansoni glutaminase 0.0269 0.219 0.3352
Schistosoma mansoni lipoxygenase 0.0118 0.0899 0.1376
Echinococcus multilocularis tubulin alpha chain 0.0018 0.0038 0.0045
Echinococcus granulosus tubulin alpha 1C chain 0.0018 0.0038 0.0045
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0235 0.0233
Echinococcus multilocularis tubulin alpha 3 chain 0.0018 0.0038 0.0045
Schistosoma mansoni hypothetical protein 0.007 0.0483 0.0739
Leishmania major carbonic anhydrase family protein, putative 0.049 0.4078 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0151 0.0367
Onchocerca volvulus 0.0035 0.0189 0.0993
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0193 0.6036
Echinococcus multilocularis tubulin alpha chain 0.0018 0.0038 0.0045
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0117 0.2956
Loa Loa (eye worm) tubulin alpha chain 0.0018 0.0038 0.0049
Echinococcus multilocularis tubulin alpha 1C chain 0.0018 0.0038 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0187 0.0221
Entamoeba histolytica biotin--acetyl-CoA-carboxylase ligase, putative 0.005 0.0318 0.0776
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0268 0.0355
Echinococcus multilocularis biotin protein ligase 0.005 0.0318 0.0376
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.126 0.1489
Loa Loa (eye worm) glutaminase 0.0269 0.219 0.2918
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0193 0.0228
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0011 0.03
Brugia malayi hypothetical protein 0.002 0.006 0.0078
Brugia malayi hypothetical protein 0.0027 0.0117 0.0153
Schistosoma mansoni alpha glucosidase 0.0036 0.0193 0.0295
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0117 0.0887 0.1358
Echinococcus multilocularis tubulin alpha chain 0.0018 0.0038 0.0045
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0317 0.0375
Echinococcus multilocularis hypothetical protein 0.0018 0.0038 0.0045
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0193 0.0469
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0317 0.9975

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 20 uM Displacement of [3H]-biotin from human BPL after 20 mins by scintillation counting ChEMBL. 24900501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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