Detailed information for compound 1656955

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.469 | Formula: C16H18N4O4S2
  • H donors: 0 H acceptors: 4 LogP: 2.37 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOc1cc2c(ncnc2cc1OCCOC)Sc1nncs1
  • InChi: 1S/C16H18N4O4S2/c1-21-3-5-23-13-7-11-12(8-14(13)24-6-4-22-2)17-9-18-15(11)26-16-20-19-10-25-16/h7-10H,3-6H2,1-2H3
  • InChiKey: ZLZOVDRPXBJYCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei beta tubulin 0.0142 0.0613 0.2291
Echinococcus granulosus beta tubulin 0.0142 0.0613 0.4194
Entamoeba histolytica tubulin family protein 0.0142 0.0613 0.4946
Echinococcus multilocularis Tubulin alpha 1 chain 0.0265 0.124 0.1466
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0735 0.5924
Echinococcus multilocularis tubulin alpha chain 0.0265 0.124 0.1466
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.02 0.0756
Schistosoma mansoni patched 1 0.0044 0.011 0.0591
Plasmodium falciparum tubulin gamma chain 0.0142 0.0613 0.2291
Echinococcus granulosus tubulin alpha 1C chain 0.0265 0.124 0.868
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0142 0.0613 0.2291
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.0039
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1641 0.8301 1
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.124 1
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Loa Loa (eye worm) tubulin beta-2A chain 0.0142 0.0613 0.4269
Brugia malayi Telomerase reverse transcriptase 0.1433 0.7237 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0035
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.011 0.01
Schistosoma mansoni transient receptor potential channel 0.0063 0.0204 0.1268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0594 0.4054
Trypanosoma cruzi beta tubulin, putative 0.0142 0.0613 0.2318
Leishmania major epsilon tubulin, putative 0.0142 0.0613 0.2318
Brugia malayi TAR-binding protein 0.0067 0.0225 0.0299
Schistosoma mansoni tubulin subunit beta 0.0142 0.0613 0.4194
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0613 0.4946
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0008
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Entamoeba histolytica tubulin family protein 0.0142 0.0613 0.4946
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0225 0.0299
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.042 0.281
Loa Loa (eye worm) hypothetical protein 0.0044 0.011 0.0712
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0369 0.2446
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0613 0.4194
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0064 0.0075
Echinococcus granulosus tubulin alpha 0.0142 0.0613 0.4194
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Brugia malayi CHE-14 protein 0.0044 0.011 0.0139
Trypanosoma brucei alpha tubulin 0.0265 0.124 0.4668
Loa Loa (eye worm) tubulin gamma chain 0.0142 0.0613 0.4269
Echinococcus multilocularis tubulin subunit beta 0.0142 0.0613 0.0708
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0296 0.2389
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0203 0.0923 0.6456
Schistosoma mansoni tubulin subunit alpha 0.0265 0.124 0.868
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0044 0.0247
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Brugia malayi Tubulin beta chain 0.0081 0.0296 0.0397
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0735 0.5924
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0613 0.4946
Echinococcus granulosus tar DNA binding protein 0.0067 0.0225 0.1417
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0613 0.2318
Echinococcus granulosus snurportin 1 0.03 0.1425 1
Echinococcus multilocularis tubulin alpha chain 0.0265 0.124 0.1466
Echinococcus granulosus alpha tubulin 0.0265 0.124 0.868
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1181 0.9524
Loa Loa (eye worm) alpha-tubulin 0.0265 0.124 0.8697
Echinococcus multilocularis tubulin alpha chain 0.0265 0.124 0.1466
Loa Loa (eye worm) beta-tubulin 0.0142 0.0613 0.4269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0594 0.0685
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0385
Trypanosoma brucei alpha tubulin 0.0265 0.124 0.4668
Schistosoma mansoni tubulin subunit beta 0.0142 0.0613 0.4194
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0044 0.012
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0735 0.5924
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0225 0.1528
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0735 0.5924
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0008
Echinococcus multilocularis tubulin gamma 1 chain 0.0142 0.0613 0.0708
Trypanosoma cruzi alpha tubulin, putative 0.0265 0.124 0.4687
Plasmodium falciparum tubulin delta chain, putative 0.0062 0.02 0.0724
Brugia malayi RNA, U transporter 1 0.008 0.0294 0.0394
Schistosoma mansoni tubulin subunit beta 0.0142 0.0613 0.4194
Trichomonas vaginalis tubulin, putative 0.0081 0.0296 0.2389
Schistosoma mansoni hypothetical protein 0.0038 0.0076 0.035
Trypanosoma cruzi tubulin delta chain 0.0062 0.02 0.0756
Echinococcus multilocularis Tubulin alpha 1 chain 0.0265 0.124 0.1466
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0412 0.3321
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0076 0.0059
Trypanosoma brucei epsilon tubulin 0.0142 0.0613 0.2291
Echinococcus granulosus Tubulin alpha 1 chain 0.0265 0.124 0.868
Schistosoma mansoni transient receptor potential channel 0.0095 0.0369 0.2446
Echinococcus granulosus tubulin alpha chain 0.0265 0.124 0.868
Brugia malayi Tubulin alpha-2 chain 0.0265 0.124 0.1703
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.1181 0.8279
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Loa Loa (eye worm) tubulin beta-4 chain 0.0142 0.0613 0.4269
Plasmodium vivax tubulin alpha chain, putative 0.0265 0.124 0.4668
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0231 0.0307
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.124 1
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.124 1
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Loa Loa (eye worm) tubulin alpha 2 0.0122 0.051 0.3536
Giardia lamblia Alpha-tubulin 0.0265 0.124 0.4252
Leishmania major hypothetical protein, conserved 0.0025 0.0009 0.0035
Giardia lamblia Alpha-tubulin 0.0265 0.124 0.4252
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Plasmodium vivax importin-beta 2, putative 0.0028 0.0027 0.0069
Schistosoma mansoni tubulin subunit alpha 0.0265 0.124 0.868
Mycobacterium tuberculosis Cell division protein FtsZ 0.0062 0.02 0.153
Loa Loa (eye worm) tubulin alpha chain 0.0265 0.124 0.8697
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.012
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0613 0.4194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0594 0.0685
Echinococcus granulosus expressed conserved protein 0.0097 0.038 0.2522
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0613 0.4269
Echinococcus multilocularis tubulin beta 1 chain 0.0142 0.0613 0.0708
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0267 0.1251 1
Toxoplasma gondii beta-tubulin, putative 0.0142 0.0613 0.2291
Treponema pallidum cell division protein FtsZ 0.0062 0.02 0.5
Brugia malayi Tubulin alpha chain 0.0265 0.124 0.1703
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1181 0.9524
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0035
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.02 0.1613
Loa Loa (eye worm) RNA binding protein 0.0067 0.0225 0.1528
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0539 0.2646 1
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0064 0.026
Entamoeba histolytica tubulin gamma chain 0.0142 0.0613 0.4946
Echinococcus multilocularis tubulin alpha chain 0.0265 0.124 0.1466
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.124 1
Echinococcus granulosus tubulin delta chain 0.0062 0.02 0.1236
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.011 0.0712
Schistosoma mansoni tubulin subunit beta 0.0142 0.0613 0.4194
Trichomonas vaginalis tubulin, putative 0.0142 0.0613 0.4946
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.124 1
Trypanosoma brucei beta tubulin 0.0142 0.0613 0.2291
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0613 0.0708
Toxoplasma gondii beta-1 tubulin, putative 0.0142 0.0613 0.2291
Giardia lamblia Telomerase catalytic subunit 0.0539 0.2646 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.0827 0.5777
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0204 0.0214
Loa Loa (eye worm) hypothetical protein 0.0054 0.0161 0.1072
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0613 0.0708
Brugia malayi alpha-tubulin 0.0265 0.124 0.1703
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0412 0.0465
Giardia lamblia Beta tubulin 0.0142 0.0613 0.169
Loa Loa (eye worm) tubulin alpha chain 0.0265 0.124 0.8697
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0128
Echinococcus granulosus tubulin alpha 3 chain 0.0265 0.124 0.868
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0594 0.0809
Echinococcus multilocularis protein patched 0.0044 0.011 0.01
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0044 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0594 0.413
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Trypanosoma brucei beta tubulin 0.0142 0.0613 0.2291
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.02 0.1613
Trypanosoma cruzi tubulin gamma chain 0.0142 0.0613 0.2318
Plasmodium vivax telomerase reverse transcriptase, putative 0.0539 0.2646 1
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0613 0.4194
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0539 0.2646 1
Echinococcus granulosus tubulin alpha chain 0.0265 0.124 0.868
Leishmania major delta tubulin, putative 0.0062 0.02 0.0756
Schistosoma mansoni tubulin subunit delta 0.0062 0.02 0.1236
Trichomonas vaginalis tubulin, putative 0.0062 0.02 0.1613
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0225 0.1417
Echinococcus granulosus tubulin epsilon chain 0.0142 0.0613 0.4194
Plasmodium falciparum importin beta, putative 0.0028 0.0027 0.0069
Echinococcus granulosus Tubulin alpha 1 chain 0.0265 0.124 0.868
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0639 0.0739
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.1355 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0613 0.4946
Plasmodium vivax tubulin beta chain, putative 0.0142 0.0613 0.2291
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0203 0.0923 0.7442
Loa Loa (eye worm) hypothetical protein 0.0099 0.0393 0.2708
Echinococcus granulosus tubulin subunit beta 0.0142 0.0613 0.4194
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0225 0.0239
Echinococcus granulosus tubulin alpha 3 chain 0.0265 0.124 0.868
Loa Loa (eye worm) hypothetical protein 0.0265 0.124 0.8697
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0353 0.233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0594 0.4054
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0532
Schistosoma mansoni alpha tubulin 0.0265 0.124 0.868
Entamoeba histolytica tubulin alpha chain, putative 0.0265 0.124 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.1181 0.1622
Plasmodium vivax tubulin gamma chain, putative 0.0142 0.0613 0.2291
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0225 0.1417
Echinococcus multilocularis hypothetical protein 0.0265 0.124 0.1466
Echinococcus multilocularis tubulin alpha 3 chain 0.0265 0.124 0.1466
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0296 0.2389
Plasmodium falciparum telomerase reverse transcriptase 0.0539 0.2646 1
Trypanosoma brucei alpha tubulin 0.0265 0.124 0.4668
Echinococcus multilocularis snurportin 1 0.03 0.1425 0.1689
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0225 0.1528
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.124 1
Schistosoma mansoni tubulin subunit epsilon 0.0142 0.0613 0.4194
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.124 1
Schistosoma mansoni alpha tubulin 0.0265 0.124 0.868
Loa Loa (eye worm) hypothetical protein 0.0095 0.0369 0.2543
Echinococcus multilocularis beta tubulin 0.0142 0.0613 0.0708
Schistosoma mansoni tubulin subunit gamma 0.0142 0.0613 0.4194
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0225 0.1417
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1181 0.9524
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.001 0.0083
Plasmodium vivax tubulin epsilon chain, putative 0.0142 0.0613 0.2291
Echinococcus multilocularis Tubulin alpha 1 chain 0.0265 0.124 0.1466
Schistosoma mansoni transient receptor potential channel 0.0063 0.0204 0.1268
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.012
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0613 0.0708
Schistosoma mansoni tubulin subunit alpha 0.0062 0.02 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1181 0.9524
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0044 0.012
Toxoplasma gondii beta tubulin 0.0142 0.0613 0.2291
Echinococcus granulosus peroxisome assembly protein 26 0.0265 0.124 0.868
Brugia malayi Tubulin gamma chain 0.0142 0.0613 0.0836
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0594 0.4054
Trypanosoma cruzi tubulin delta chain 0.0062 0.02 0.0756
Echinococcus granulosus beta tubulin 0.0142 0.0613 0.4194
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.02 0.0756
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0735 0.5924
Schistosoma mansoni tubulin subunit beta 0.0062 0.02 0.1236
Echinococcus granulosus tubulin alpha chain 0.0265 0.124 0.868
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0296 0.2389
Trypanosoma brucei alpha tubulin 0.0265 0.124 0.4668
Loa Loa (eye worm) tubulin beta chain 0.0062 0.02 0.1349
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Trypanosoma brucei beta tubulin 0.0142 0.0613 0.2291
Toxoplasma gondii alpha tubulin TUBA1 0.0265 0.124 0.4668
Echinococcus multilocularis tubulin epsilon chain 0.0142 0.0613 0.0708
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0613 0.4946
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0062 0.02 0.5
Brugia malayi Tubulin beta-1 chain 0.0142 0.0613 0.0836
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0081 0.0296 0.2389
Echinococcus multilocularis tubulin alpha chain 0.0265 0.124 0.1466
Entamoeba histolytica hypothetical protein 0.0038 0.0076 0.0614
Loa Loa (eye worm) tubulin alpha 2 0.0203 0.0923 0.6456
Entamoeba histolytica tubulin alpha-1 chain 0.0265 0.124 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0393 0.053
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0204 0.1268
Plasmodium falciparum tubulin epsilon chain, putative 0.0142 0.0613 0.2291
Brugia malayi RNA binding protein 0.0067 0.0225 0.0299
Giardia lamblia Beta tubulin 0.0142 0.0613 0.169
Brugia malayi beta-tubulin, identical 0.0142 0.0613 0.0836
Loa Loa (eye worm) tubulin beta-1 chain 0.0142 0.0613 0.4269
Echinococcus granulosus tubulin alpha 1C chain 0.0265 0.124 0.868
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.1355 1
Schistosoma mansoni tubulin subunit beta 0.0142 0.0613 0.4194
Brugia malayi hypothetical protein 0.0038 0.0076 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0735 0.5924
Leishmania major zeta tubulin, putative 0.0062 0.02 0.0756
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Loa Loa (eye worm) tubulin alpha-3 chain 0.0184 0.0827 0.5777
Brugia malayi tubulin alpha chain - mouse 0.0265 0.124 0.1703
Schistosoma mansoni tubulin subunit alpha 0.0265 0.124 0.868
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0296 0.2389
Echinococcus granulosus tubulin alpha chain 0.0265 0.124 0.868
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Plasmodium vivax delta tubulin, putative 0.0062 0.02 0.0724
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1181 0.9524
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0002
Echinococcus multilocularis tubulin subunit TubB 0.0265 0.124 0.1466
Echinococcus multilocularis expressed conserved protein 0.0097 0.038 0.0426
Trypanosoma brucei epsilon tubulin 0.0142 0.0613 0.2291
Trypanosoma brucei telomerase reverse transcriptase 0.0539 0.2646 1
Leishmania major telomerase reverse transcriptase, putative 0.0539 0.2646 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.02 0.0724
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0613 0.4194
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0412 0.2752
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0532
Brugia malayi Importin beta-1 subunit 0.0028 0.0027 0.0025
Trypanosoma brucei epsilon tubulin 0.0142 0.0613 0.2291
Trypanosoma brucei tubulin gamma chain 0.0142 0.0613 0.2291
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0044 0.002
Plasmodium falciparum tubulin beta chain 0.0142 0.0613 0.2291
Echinococcus multilocularis tubulin alpha 1C chain 0.0265 0.124 0.1466
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.124 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0781 0.6294
Loa Loa (eye worm) tubulin beta chain 0.0142 0.0613 0.4269
Brugia malayi Cell division protein ftsZ 0.0062 0.02 0.0264
Toxoplasma gondii alpha-tubulin I, putative 0.0265 0.124 0.4668
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0204 0.0214
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0613 0.0708
Entamoeba histolytica hypothetical protein 0.0038 0.0076 0.0614
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0353 0.0393
Mycobacterium ulcerans cell division protein FtsZ 0.0062 0.02 0.1412
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0265 0.124 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0265 0.124 0.868
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0594 0.4054
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0002
Echinococcus multilocularis protein dispatched 1 0.005 0.0142 0.0139
Echinococcus multilocularis peroxisome assembly protein 26 0.0265 0.124 0.1466
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0594 0.4054
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0076 0.035
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0225 0.1417
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0044 0.002
Brugia malayi Tubulin alpha chain 0.0062 0.02 0.0264
Echinococcus multilocularis tubulin alpha 0.0142 0.0613 0.0708
Echinococcus granulosus tubulin alpha chain 0.0265 0.124 0.868
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0735 0.0725
Brugia malayi Tubulin beta chain 0.0062 0.02 0.0264
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0532
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0008
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0639 0.4376
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.012
Trichomonas vaginalis tubulin beta chain, putative 0.0142 0.0613 0.4946
Echinococcus granulosus tubulin subunit TubB 0.0265 0.124 0.868
Trypanosoma brucei tubulin delta chain 0.0062 0.02 0.0724
Schistosoma mansoni hypothetical protein 0.0068 0.0231 0.146
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0204 0.1268
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0393 0.053
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Loa Loa (eye worm) hypothetical protein 0.0068 0.0231 0.1569
Trypanosoma brucei zeta tubulin 0.0062 0.02 0.0724
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0027 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1181 0.9524
Loa Loa (eye worm) tubulin alpha 2 0.0203 0.0923 0.6456
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0613 0.4194
Loa Loa (eye worm) alpha-tubulin 0.0265 0.124 0.8697
Trypanosoma brucei zeta tubulin, putative 0.0062 0.02 0.0724
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Loa Loa (eye worm) hypothetical protein 0.0103 0.0412 0.2845
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0044 0.0048
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0142 0.0613 0.0708
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0369 0.2446
Echinococcus multilocularis tubulin delta chain 0.0062 0.02 0.0209
Trichomonas vaginalis tubulin, putative 0.0081 0.0296 0.2389
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.001 0.0083
Mycobacterium leprae cell division protein FtsZ 0.0062 0.02 1
Brugia malayi tubulin alpha-2 chain 0.0265 0.124 0.1703
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0393 0.2708
Loa Loa (eye worm) hypothetical protein 0.006 0.0188 0.1265
Echinococcus granulosus tubulin beta 4A class IVa 0.0142 0.0613 0.4194
Plasmodium falciparum alpha tubulin 1 0.0265 0.124 0.4668
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.011 0.0886
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0271
Toxoplasma gondii RNA-directed DNA polymerase 0.0539 0.2646 1
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.011 0.0591
Entamoeba histolytica hypothetical protein 0.0038 0.0076 0.0614
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0062 0.02 0.1613
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0002
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0532
Echinococcus multilocularis GPCR, family 2 0.0031 0.0044 0.002
Brugia malayi Tubulin alpha-2 chain 0.0265 0.124 0.1703
Trichomonas vaginalis tubulin epsilon chain, putative 0.0062 0.02 0.1613
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0613 0.4269
Giardia lamblia Gamma tubulin 0.0142 0.0613 0.169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0076 0.035
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0369 0.0413
Echinococcus multilocularis tubulin alpha 3 chain 0.0265 0.124 0.1466
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0412 0.0557
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0735 0.5924
Onchocerca volvulus 0.0081 0.0296 0.0286
Schistosoma mansoni hypothetical protein 0.03 0.1425 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0247
Plasmodium falciparum alpha tubulin 2 0.0265 0.124 0.4668
Loa Loa (eye worm) tubulin alpha-2 chain 0.0265 0.124 0.8697
Loa Loa (eye worm) hypothetical protein 0.0203 0.0923 0.6456
Schistosoma mansoni alpha tubulin 0.0265 0.124 0.868
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.012
Echinococcus granulosus Protein patched homolog 1 0.0044 0.011 0.0591
Leishmania major alpha tubulin 0.0265 0.124 0.4687
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0064 0.0044
Plasmodium vivax tubulin alpha chain, putative 0.0265 0.124 0.4668
Schistosoma mansoni tubulin subunit beta 0.0142 0.0613 0.4194
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0027 0.0069
Echinococcus granulosus tubulin beta 1 chain 0.0142 0.0613 0.4194
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0027 0.0069
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0613 0.4946
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0613 0.0708
Echinococcus granulosus GPCR family 2 0.0031 0.0044 0.012
Leishmania major gamma-tubulin 0.0142 0.0613 0.2318
Trypanosoma brucei beta tubulin 0.0142 0.0613 0.2291
Trypanosoma brucei alpha tubulin, putative 0.0081 0.0296 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.02 0.1613
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0225 0.1417
Leishmania major beta tubulin 0.0142 0.0613 0.2318
Giardia lamblia Beta tubulin 0.0142 0.0613 0.169
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0613 0.4946
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0781 0.6294
Entamoeba histolytica hypothetical protein 0.0038 0.0076 0.0614
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.1425 1
Echinococcus granulosus tubulin gamma 1 chain 0.0142 0.0613 0.4194
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0613 0.4946
Echinococcus multilocularis beta tubulin 0.0142 0.0613 0.0708
Echinococcus multilocularis tubulin alpha 1C chain 0.0265 0.124 0.1466
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0184 0.0827 0.6667
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.001 0.0083
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.02 0.0724
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0613 0.2318

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.35 uM Cytotoxicity against FLT3-dependent human MV4-11 cells after 72 hrs by MTT assay ChEMBL. 22452518

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22452518

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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