Detailed information for compound 1659184

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.595 | Formula: C25H29N5O2S
  • H donors: 1 H acceptors: 4 LogP: 3.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CC1)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1scc(n1)c1ccccc1
  • InChi: 1S/C25H29N5O2S/c26-17-25(10-11-25)28-22(31)19-8-4-5-9-20(19)23(32)29-12-14-30(15-13-29)24-27-21(16-33-24)18-6-2-1-3-7-18/h1-3,6-7,16,19-20H,4-5,8-15H2,(H,28,31)/t19-,20-/m1/s1
  • InChiKey: NEWCBLDMKSRBBC-WOJBJXKFSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Schistosoma mansoni myelin transcription factor 1 myt1 0.0045 0.1291 0.1218
Entamoeba histolytica cysteine protease, putative 0.0059 0.1924 0.5373
Schistosoma mansoni survival motor neuron protein 0.0039 0.1052 0.0978
Echinococcus granulosus SAM and MBT domain containing protein 0.0039 0.1047 0.0409
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.1924 0.2418
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.327 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.1125 0.2627
Mycobacterium ulcerans 6-phosphofructokinase 0.0089 0.327 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1125 0.1414
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0045 0.1291 0.1622
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1924 0.5373
Loa Loa (eye worm) hypothetical protein 0.0021 0.0208 0.0262
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1924 0.2686
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0752 0.105
Loa Loa (eye worm) hypothetical protein 0.0122 0.4761 0.5985
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0961 0.1208
Plasmodium vivax vivapain-2 0.0059 0.1924 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Plasmodium vivax unspecified product 0.0033 0.0752 0.3634
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.7163 0.714
Onchocerca volvulus 0.0059 0.1924 1
Echinococcus granulosus muscleblind protein 0.0122 0.4761 0.5566
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Schistosoma mansoni sex comb on midleg homolog 0.0039 0.1047 0.0972
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0089 0.327 0.5
Echinococcus granulosus 6 phosphofructokinase 0.0089 0.327 0.3495
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1924 0.5373
Schistosoma mansoni 6-phosphofructokinase 0.0089 0.327 0.3213
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0191 0.7843 0.986
Echinococcus multilocularis cysteine protease 0.0059 0.1924 0.1627
Brugia malayi hypothetical protein 0.0193 0.7955 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0083 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0961 0.0886
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0961 0.0291
Echinococcus multilocularis histone acetyltransferase MYST2 0.0045 0.1291 0.0748
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0208 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0961 0.0886
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0155 0.623 0.7606
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.2183 0.6676
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Onchocerca volvulus Cathepsin F homolog 0.0059 0.1924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.2183 0.6264
Brugia malayi Cathepsin L-like precursor 0.0041 0.1125 0.1414
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.327 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0083 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Brugia malayi Cytochrome P450 family protein 0.0024 0.0381 0.0479
Toxoplasma gondii phosphofructokinase PFKII 0.0024 0.0361 0.0772
Brugia malayi 6-phosphofructokinase 0.0089 0.327 0.411
Brugia malayi phosphofructokinase 0.0089 0.327 0.411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0752 0.105
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.1924 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0045 0.1291 0.0748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0752 0.0675
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0961 0.0291
Leishmania major ATP-dependent phosphofructokinase 0.0089 0.327 1
Leishmania major hypothetical protein, conserved 0.0021 0.0208 0.0637
Brugia malayi Cathepsin L-like precursor 0.0059 0.1924 0.2418
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0089 0.327 1
Onchocerca volvulus 0.0059 0.1924 1
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.1924 0.2686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0961 0.0291
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0208 0.068
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0752 0.105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0083 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0961 0.0886
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0089 0.327 0.4564
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0208 0.0291
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Loa Loa (eye worm) MBCTL1 0.0045 0.1291 0.1622
Echinococcus multilocularis survival motor neuron protein 1 0.0193 0.7955 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0752 0.23
Plasmodium vivax vivapain-2 0.0059 0.1924 1
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0083 0.0116
Brugia malayi Muscleblind-like protein 0.0122 0.4761 0.5985
Giardia lamblia Cathepsin B precursor 0.0065 0.2183 1
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1924 0.2686
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0089 0.327 0.5
Echinococcus multilocularis muscleblind protein 0.0122 0.4761 0.5566
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0024 0.0361 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Echinococcus granulosus cathepsin b 0.0176 0.7163 0.8901
Onchocerca volvulus 0.0059 0.1924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0752 0.23
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.1924 0.2418
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.1924 0.1627
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1924 0.1627
Brugia malayi Cathepsin L-like precursor 0.0059 0.1924 0.2418
Schistosoma mansoni sex comb on midleg homolog 0.0039 0.1047 0.0972
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0961 0.1208
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0039 0.1047 0.0972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.1125 0.2627
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.1924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.1125 0.2627
Loa Loa (eye worm) ctsf protein 0.0059 0.1924 0.2418
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1924 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0752 0.1345
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.7163 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1924 0.1627
Brugia malayi mbt repeat family protein 0.0039 0.1047 0.1316
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0155 0.623 0.7606
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0961 0.0291
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1924 0.1627
Toxoplasma gondii cathepsin CPL 0.0059 0.1924 0.8688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0752 0.105
Loa Loa (eye worm) 6-phosphofructokinase 0.0089 0.327 0.411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0752 0.1345
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.2183 0.2118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Loa Loa (eye worm) hypothetical protein 0.0193 0.7955 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.1924 0.1627
Echinococcus granulosus survival motor neuron protein 1 0.0193 0.7955 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Echinococcus multilocularis polycomb protein SCMH1 0.0039 0.1047 0.0409
Loa Loa (eye worm) hypothetical protein 0.0041 0.1125 0.1414
Toxoplasma gondii 6-phosphofructokinase 0.0024 0.0361 0.0772
Brugia malayi Cathepsin L-like precursor 0.0059 0.1924 0.2418
Echinococcus granulosus cathepsin l1 0.0041 0.1125 0.0518
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0381 0.0479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1924 0.1856
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0083 0.0104
Brugia malayi Cathepsin L-like precursor 0.0059 0.1924 0.2418
Brugia malayi Cathepsin L-like precursor 0.0041 0.1125 0.1414
Loa Loa (eye worm) hypothetical protein 0.0041 0.1125 0.1414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0752 0.1345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Schistosoma mansoni hypothetical protein 0.0039 0.1052 0.0978
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0752 0.1345
Loa Loa (eye worm) 6-phosphofructokinase 0.0089 0.327 0.411
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1924 0.2686
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0752 0.0945
Onchocerca volvulus 0.0059 0.1924 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.7163 0.714
Entamoeba histolytica phosphofructokinase, putative 0.0089 0.327 1
Giardia lamblia Cathepsin B precursor 0.0065 0.2183 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Onchocerca volvulus 0.0059 0.1924 1
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0752 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0361 0.1509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0208 0.0637
Onchocerca volvulus 0.0039 0.1052 0.0066
Brugia malayi 6-phosphofructokinase 0.0089 0.327 0.411
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0752 0.1345
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.0752 0.3169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0083 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.327 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0039 0.1052 0.1323
Giardia lamblia Cathepsin B precursor 0.0065 0.2183 1
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.327 1
Schistosoma mansoni 6-phosphofructokinase 0.0089 0.327 0.3213
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Loa Loa (eye worm) hypothetical protein 0.0059 0.1924 0.2418
Onchocerca volvulus 0.0041 0.1125 0.0891
Toxoplasma gondii cathepsin B 0.0065 0.2183 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0024 0.0361 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Brugia malayi mbt repeat family protein 0.0039 0.1047 0.1316
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.7163 0.714
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0752 0.0675
Echinococcus granulosus cathepsin l1 0.0059 0.1924 0.1627
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1924 0.1627
Loa Loa (eye worm) hypothetical protein 0.0018 0.0083 0.0104
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1924 1
Brugia malayi follicle stimulating hormone receptor 0.0191 0.7843 0.986
Loa Loa (eye worm) cathepsin B 0.0065 0.2183 0.2744
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1924 0.5373
Plasmodium vivax vivapain-1 0.0033 0.0752 0.3634
Echinococcus multilocularis cysteine protease 0.0059 0.1924 0.1627
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.327 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Echinococcus multilocularis cathepsin b 0.0176 0.7163 0.8901
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.1125 0.157
Loa Loa (eye worm) fibroinase 0.0059 0.1924 0.2418
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.2183 0.3047
Brugia malayi Cathepsin L-like precursor 0.0059 0.1924 0.2418
Loa Loa (eye worm) hypothetical protein 0.0122 0.4761 0.5985
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0361 0.1509
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.1924 0.2418
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1924 0.1856
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.1924 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0752 0.1345
Echinococcus granulosus polycomb protein SCMH1 0.0039 0.1047 0.0409
Brugia malayi cathepsin L-like precursor 0.0041 0.1125 0.1414
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0024 0.0361 0.0772
Loa Loa (eye worm) hypothetical protein 0.0039 0.1047 0.1316
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.7163 0.9005
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0361 0.0889
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.2183 0.6676
Echinococcus granulosus histone acetyltransferase MYST2 0.0045 0.1291 0.0748
Loa Loa (eye worm) hypothetical protein 0.0176 0.7163 0.9005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Leishmania major cathepsin L-like protease 0.0059 0.1924 0.5884
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0752 0.0945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1924 0.5884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Echinococcus granulosus cathepsin b 0.0176 0.7163 0.8901
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0045 0.1291 0.0748
Loa Loa (eye worm) hypothetical protein 0.0045 0.1291 0.1622
Brugia malayi hypothetical protein 0.0021 0.0208 0.0262
Leishmania major cysteine peptidase A (CPA) 0.0059 0.1924 0.5884
Onchocerca volvulus 0.0059 0.1924 1
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0752 0.105
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.1125 0.1414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1924 0.5373
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0083 0.0104
Loa Loa (eye worm) cysteine protease 0.0059 0.1924 0.2418
Trichomonas vaginalis phosphofructokinase, putative 0.0089 0.327 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Echinococcus multilocularis cathepsin b 0.0176 0.7163 0.8901
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0089 0.327 1
Echinococcus multilocularis 6 phosphofructokinase 0.0089 0.327 0.3495
Echinococcus multilocularis muscleblind protein 1 0.0122 0.4761 0.5566
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1924 0.5373
Plasmodium vivax vivapain-3 0.0033 0.0752 0.3634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.7163 0.714
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.1125 0.1051
Loa Loa (eye worm) phosphofructokinase 0.0089 0.327 0.411
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0083 0.0116
Loa Loa (eye worm) mbt repeat family protein 0.0039 0.1047 0.1316
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0752 0.0675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Brugia malayi Cathepsin L-like precursor 0.0059 0.1924 0.2418
Onchocerca volvulus 0.0059 0.1924 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0361 0.0889
Echinococcus multilocularis SAM and MBT domain containing protein 0.0039 0.1047 0.0409
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1924 0.2686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1924 0.5373
Entamoeba histolytica cysteine protease, putative 0.0033 0.0752 0.1345
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0752 0.1345

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 4 Inhibition of human recombinant cathepsin L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142
IC50 (binding) = 4.6 Inhibition of human ERG ChEMBL. 22858142
IC50 (binding) = 5.4 Inhibition of human recombinant cathepsin B using Z-Arg-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142
IC50 (binding) = 5.8 Inhibition of human recombinant cathepsin S using Z-Val-Val-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142
IC50 (binding) = 7.8 Inhibition of human recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.