Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.5596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0116 | 0.5596 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0116 | 0.5596 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0116 | 0.5596 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.5596 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0116 | 0.5596 | 0.5596 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0116 | 0.5596 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 1 | 1 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0031 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0116 | 0.5596 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.5596 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0116 | 0.5596 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0116 | 0.5596 | 0.5596 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0116 | 0.5596 | 0.5596 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0116 | 0.5596 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.5596 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0116 | 0.5596 | 0.5596 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0116 | 0.5596 | 0.5596 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0116 | 0.5596 | 0.5596 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0116 | 0.5596 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0032 | 0.0069 | 0.0069 |
Plasmodium vivax | amine transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0116 | 0.5596 | 0.5596 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0116 | 0.5596 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0116 | 0.5596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 71 uM kg-1 | Assessed for thymoleptic activity by its ability to antagonize tetrabenazine ptosis in mice | ChEMBL. | 6134833 |
IC50 (functional) | = 0.3 nM | Effect on synaptosomal uptake inhibition of Noradrenaline (NA) | ChEMBL. | 6134833 |
IC50 (functional) | = 5.6 nM | Effect on synaptosomal uptake inhibition of Dopamine receptor | ChEMBL. | 6134833 |
IC50 (functional) | = 440 nM | Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT) | ChEMBL. | 6134833 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.