Detailed information for compound 1665917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 204.225 | Formula: C11H12N2O2
  • H donors: 2 H acceptors: 3 LogP: 1.59 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC[C@@H]1[C@H]2[C@@H]1c1c(C2)c(n[nH]1)C(=O)O
  • InChi: 1S/C11H12N2O2/c1-2-3-5-6-4-7-9(8(5)6)12-13-10(7)11(14)15/h2,5-6,8H,1,3-4H2,(H,12,13)(H,14,15)/t5-,6+,8-/m1/s1
  • InChiKey: PFNXDXYYLHIYHO-GKROBHDKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxycarboxylic acid receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis G-protein coupled receptor, putative hydroxycarboxylic acid receptor 2 363 aa 294 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1114 0.1114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0139 0.162 0.3716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Onchocerca volvulus 0.0037 0.0322 0.0739
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.035 0.4298 1
Brugia malayi beta-lactamase 0.0035 0.0299 0.0685
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus granulosus Dipeptidyl peptidase 9 0.0142 0.1652 0.379
Brugia malayi ORL1-like opioid receptor 0.0032 0.026 0.0597
Brugia malayi sulfakinin receptor protein 0.0032 0.026 0.0597
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0299 0.0332
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0178 0.0407
Schistosoma mansoni hypothetical protein 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Brugia malayi hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0262 0.0601
Trypanosoma brucei aurora B kinase 0.005 0.0486 0.1061
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0002
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0355 0.4359 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0026 0.0059
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0107 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1114 0.1236
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0107 0.0246
Schistosoma mansoni hypothetical protein 0.0032 0.026 0.0289
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0169 0.0317
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0299 0.0692
Onchocerca volvulus 0.0012 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0082 0.0892 0.0991
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0355 0.4359 1
Leishmania major hypothetical protein, conserved 0.0033 0.0262 0.0607
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0145 0.0332
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0169 0.039
Brugia malayi nuclear receptor NHR-88 0.002 0.0107 0.0246
Echinococcus granulosus FTZ F1 alpha 0.002 0.0107 0.0246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Onchocerca volvulus 0.0012 0.0001 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0299 0.1314
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.026 0.026
Trypanosoma cruzi oligopeptidase b 0.0154 0.1812 0.4215
Mycobacterium leprae Probable lipase LipE 0.0035 0.0299 0.0923
Echinococcus granulosus geminin 0.0225 0.2705 0.6205
Entamoeba histolytica cell division protein kinase 2, putative 0.0039 0.0339 0.0803
Trypanosoma cruzi PAB1-binding protein , putative 0.0033 0.0262 0.0607
Onchocerca volvulus 0.0032 0.026 0.0597
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0299 0.2511
Loa Loa (eye worm) TK/INSR protein kinase 0.0075 0.0801 0.1839
Trichomonas vaginalis cyclin B, putative 0.0027 0.0192 0.1246
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.1114 0.2555
Onchocerca volvulus 0.0032 0.026 0.0597
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.026 0.0597
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.002 0.0103 0.0237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0178 0.0178
Brugia malayi Cyclin, N-terminal domain containing protein 0.0065 0.0673 0.1544
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.026 0.026
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0059 0.0604 0.1337
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0034 0.0077
Toxoplasma gondii hypothetical protein 0.0021 0.0109 0.0251
Entamoeba histolytica cyclin, putative 0.0027 0.0192 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0604 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0145 0.0431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0025 0.0169 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0381 0.3485
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0059 0.0604 0.6124
Brugia malayi GnHR receptor homolog 0.0032 0.026 0.0597
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0169 0.0973
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0685
Echinococcus granulosus expressed conserved protein 0.0187 0.222 0.5092
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0107 0.0107
Trypanosoma cruzi aurora B kinase, putative 0.005 0.0486 0.1128
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.026 0.0597
Schistosoma mansoni sodium/solute symporter 0.003 0.0223 0.0248
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0178 0.0407
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.026 0.0597
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0034 0.0075
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0169 0.0387
Onchocerca volvulus 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0107 0.0107
Onchocerca volvulus 0.0012 0.0001 0.0002
Echinococcus granulosus orexin receptor type 2 0.0032 0.026 0.0597
Brugia malayi Patched protein homolog 1 0.0012 0.0001 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.026 0.0289
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0065 0.0673 0.1563
Schistosoma mansoni tyrosine kinase 0.0075 0.0801 0.089
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.026 0.0597
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.026 0.0597
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0145 0.0431
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0107 0.0246
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.026 0.0289
Entamoeba histolytica serine/threonine protein kinase, putative 0.0083 0.0909 0.226
Echinococcus granulosus cyclins 0.0027 0.0192 0.044
Echinococcus granulosus insulin receptor 0.0075 0.0801 0.1839
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.026 0.0597
Trichomonas vaginalis cyclin D, putative 0.0027 0.0192 0.1246
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Schistosoma mansoni biogenic amine receptor 0.0032 0.026 0.0289
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0178 0.0407
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0107 0.0107
Brugia malayi Dopamine receptor protein 1 0.0032 0.026 0.0597
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0107 0.0246
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.1114 0.2555
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.007 0.1139
Schistosoma mansoni hypothetical protein 0.0225 0.2705 0.3003
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0909 0.9735
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Trichomonas vaginalis cyclins, putative 0.0065 0.0673 0.694
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0154 0.1812 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0026 0.0178 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0107 0.0246
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0299 0.0692
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0107 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0107 0.0246
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0044 0.0408 0.0408
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.026 0.0597
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0299 0.2511
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0178 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0107 0.0246
Onchocerca volvulus 0.0012 0.0001 0.0003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0169 0.039
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0034 0.0034
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.026 0.0597
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0107 0.0119
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.2373 0.6005
Mycobacterium ulcerans lipase LipD 0.0035 0.0299 0.1314
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Trypanosoma cruzi CYC2-like cyclin, putative 0.0065 0.0673 0.1563
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0154 0.1812 0.4215
Trypanosoma cruzi cyclin, putative 0.0065 0.0673 0.1563
Echinococcus multilocularis nAChR subunit 0.0014 0.0026 0.0026
Brugia malayi hypothetical protein 0.0082 0.0896 0.2055
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0083 0.0909 0.2086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0145 0.0431
Loa Loa (eye worm) GABA receptor subunit 0.0014 0.0026 0.0059
Echinococcus multilocularis fmrfamide receptor 0.0032 0.026 0.026
Echinococcus multilocularis cyclin B 0.0065 0.0673 0.0673
Trichomonas vaginalis cyclins, putative 0.0065 0.0673 0.694
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.026 0.026
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0015 0.0034 0.0077
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.026 0.0597
Echinococcus multilocularis tissue type plasminogen activator 0.0012 0.0001 0.0001
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0026 0.0178 0.0407
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.026 0.026
Brugia malayi Serotonin receptor 0.0032 0.026 0.0597
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.005 0.0486 0.1178
Brugia malayi hypothetical protein 0.0021 0.0115 0.0265
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0034 0.0541
Giardia lamblia Aurora kinase 0.005 0.0486 0.0843
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0685
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.003 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Plasmodium falciparum ataxin-2 like protein, putative 0.0033 0.0262 0.433
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.026 0.0597
Echinococcus multilocularis Niemann Pick C1 protein 0.0284 0.3456 0.3456
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0299 0.0755
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.007 0.0103
Echinococcus multilocularis cyclin B3 1 0.0027 0.0192 0.0192
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Onchocerca volvulus 0.0023 0.0145 0.0332
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0059 0.0604 0.0671
Schistosoma mansoni tyrosine kinase 0.0034 0.0282 0.0313
Loa Loa (eye worm) TTK protein kinase 0.0064 0.066 0.1515
Schistosoma mansoni neuropeptide receptor 0.0032 0.026 0.0289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0058 0.0068
Trichomonas vaginalis cyclin B, putative 0.0065 0.0673 0.694
Schistosoma mansoni protein kinase 0.005 0.0486 0.054
Schistosoma mansoni inositol transporter 0.003 0.0223 0.0248
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0154 0.1812 0.4171
Brugia malayi putative neuropeptide receptor 0.0032 0.026 0.0597
Schistosoma mansoni hypothetical protein 0.0082 0.0892 0.0991
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0026 0.0178 0.0407
Onchocerca volvulus Protein patched homolog 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Schistosoma mansoni tyrosine kinase 0.0034 0.0282 0.0313
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0739
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0058 0.0068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0032 0.026 0.026
Onchocerca volvulus 0.0026 0.0178 0.0407
Echinococcus multilocularis tumor protein p63 0.0255 0.3089 0.3089
Brugia malayi AKH receptor 0.0032 0.026 0.0597
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0154 0.1812 0.507
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0931 0.2137
Plasmodium falciparum peptidase, putative 0.0059 0.0604 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0083 0.0909 0.0909
Brugia malayi GH02984p 0.0268 0.325 0.7457
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.035 0.4298 0.4772
Entamoeba histolytica hypothetical protein 0.0022 0.0128 0.0263
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Plasmodium falciparum ataxin-2 like protein, putative 0.0033 0.0262 0.433
Onchocerca volvulus 0.0047 0.0452 0.1036
Onchocerca volvulus 0.0035 0.0299 0.0685
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.026 0.0597
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1114 0.1114
Brugia malayi Patched related family protein 10 0.0012 0.0001 0.0002
Giardia lamblia DNA repair protein RAD52 0.0321 0.3934 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0023 0.0145 0.0332
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0604 0.6124
Onchocerca volvulus 0.0032 0.026 0.0597
Brugia malayi beta-lactamase family protein 0.0035 0.0299 0.0685
Loa Loa (eye worm) hypothetical protein 0.0085 0.0931 0.2137
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.026 0.0597
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.026 0.0597
Leishmania major cyclin 0.0065 0.0673 0.1563
Loa Loa (eye worm) latrophilin receptor protein 2 0.0044 0.0408 0.0937
Trypanosoma cruzi PAB1-binding protein , putative 0.0033 0.0262 0.0607
Echinococcus multilocularis Lipid transport protein, N terminal 0.0071 0.0748 0.0748
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2728 0.7679
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.026 0.0289
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0026 0.0178 0.0197
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.016
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Mycobacterium ulcerans hypothetical protein 0.0035 0.0299 0.1314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0107 0.0246
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0026 0.0178 0.0178
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0387
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0059 0.0604 0.0671
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0486 0.054
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Schistosoma mansoni hypothetical protein 0.0095 0.1059 0.1176
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0064 0.066 0.1515
Loa Loa (eye worm) hypothetical protein 0.0125 0.1434 0.329
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0039 0.0339 0.0778
Echinococcus multilocularis sodium:myo inositol cotransporter 0.003 0.0223 0.0223
Entamoeba histolytica hypothetical protein 0.0022 0.0128 0.0263
Echinococcus granulosus hypothetical protein 0.0032 0.026 0.0597
Trypanosoma brucei mitotic cyclin 6 0.0065 0.0673 0.1499
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0299 0.0755
Entamoeba histolytica protein kinase, putative 0.005 0.0486 0.1178
Brugia malayi protein C24B5.3 0.0012 0.0001 0.0002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0034 0.0282 0.0646
Echinococcus multilocularis prolyl endopeptidase 0.035 0.4298 0.4298
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.016
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0044 0.0408 0.0937
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0452 0.1036
Echinococcus granulosus Niemann Pick C1 protein 0.0284 0.3456 0.7929
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0299 0.0755
Echinococcus multilocularis cyclin dependent kinase 1 0.0039 0.0339 0.0339
Trypanosoma brucei oligopeptidase b 0.0154 0.1812 0.4171
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0299 0.2511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0178 0.0407
Trichomonas vaginalis cyclin B3, putative 0.0027 0.0192 0.1246
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0145 0.0305
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0178 0.0407
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Echinococcus multilocularis expressed conserved protein 0.0187 0.222 0.222
Echinococcus granulosus prolyl endopeptidase 0.035 0.4298 0.9861
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0026 0.0178 0.0407
Entamoeba histolytica protein kinase, putative 0.005 0.0486 0.1178
Loa Loa (eye worm) transcription factor SMAD2 0.011 0.1251 0.2871
Echinococcus granulosus cyclins 0.0027 0.0192 0.044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0107 0.0246
Echinococcus granulosus microsomal triglyceride transfer protein large 0.0125 0.1434 0.329
Brugia malayi serine/threonine kinase 12 0.005 0.0486 0.1115
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Brugia malayi hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0408 0.0937
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0145 0.0332
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0107 0.0246
Giardia lamblia Alanyl dipeptidyl peptidase 0.0059 0.0604 0.1156
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0034 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0486 0.1178
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0034 0.0077
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0012 0.0001 0.0005
Brugia malayi beta-lactamase family protein 0.0035 0.0299 0.0685
Loa Loa (eye worm) hypothetical protein 0.0104 0.1175 0.2696
Brugia malayi Protein kinase domain containing protein 0.0041 0.0375 0.0861
Echinococcus multilocularis nAChR subunit 0.0026 0.0178 0.0178
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0026 0.0178 0.0407
Schistosoma mansoni opsin-like receptor 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0685
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.026 0.0289
Brugia malayi G-protein coupled receptor 0.0032 0.026 0.0597
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0026 0.0059
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0107 0.0246
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.0604 0.148
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0909 0.9735
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.035 0.4298 0.9861
Schistosoma mansoni hypothetical protein 0.0032 0.026 0.0289
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.005 0.0486 0.1178
Echinococcus granulosus epidermal growth factor receptor 0.0034 0.0282 0.0646
Brugia malayi serine/threonine protein kinase 6 0.005 0.0486 0.1115
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0034 0.0077
Echinococcus multilocularis cyclins 0.0027 0.0192 0.0192
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.026 0.0597
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0145 0.0305
Schistosoma mansoni amine GPCR 0.072 0.9008 1
Echinococcus multilocularis g protein coupled receptor 0.0032 0.026 0.026
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus granulosus aurora kinase A 0.005 0.0486 0.1115
Trichomonas vaginalis cyclin B, putative 0.0065 0.0673 0.694
Echinococcus multilocularis insulin receptor 0.0075 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0233 0.2808 0.6443
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.026 0.026
Onchocerca volvulus 0.0012 0.0001 0.0002
Brugia malayi Dopamine receptor protein 2 0.0032 0.026 0.0597
Brugia malayi RE15519p 0.0032 0.026 0.0597
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0022 0.0128 0.0128
Echinococcus multilocularis cyclins 0.0027 0.0192 0.0192
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.026 0.0597
Brugia malayi Latrophilin receptor protein 2 0.0044 0.0408 0.0937
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0299 0.2511
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0154 0.1812 0.4215
Loa Loa (eye worm) hypothetical protein 0.0059 0.0604 0.1386
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0107 0.0246
Loa Loa (eye worm) hypothetical protein 0.0139 0.162 0.3716
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0299 0.0755
Toxoplasma gondii hypothetical protein 0.0059 0.0604 0.1403
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0299 0.1314
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.026 0.026
Loa Loa (eye worm) AUR protein kinase 0.005 0.0486 0.1115
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0107 0.0246
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0139 0.162 0.3716
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0145 0.0317
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0002
Echinococcus granulosus cyclins 0.0027 0.0192 0.044
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0299 0.0622
Schistosoma mansoni adenoreceptor 0.0032 0.026 0.0289
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.026 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0107 0.0246
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0026 0.0178 0.0178
Echinococcus multilocularis cyclins 0.0027 0.0192 0.0192
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0107 0.0119
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0034 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Echinococcus granulosus cyclin dependent kinase 1 0.0039 0.0339 0.0778
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0604 0.1403
Schistosoma mansoni tyrosine kinase 0.0034 0.0274 0.0304
Echinococcus granulosus neuropeptide receptor 0.0032 0.026 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0909 0.1009
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.0604 0.1386
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.2373 0.5444
Onchocerca volvulus Prolyl endopeptidase homolog 0.035 0.4298 0.9861
Schistosoma mansoni neuropeptide receptor 0.0032 0.026 0.0289
Trypanosoma brucei prolyl endopeptidase 0.035 0.4298 1
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0107 0.0246
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0178 0.0407
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.002 0.0103 0.0237
Brugia malayi serine/threonine-protein kinase 6 0.005 0.0486 0.1115
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.026 0.0597
Brugia malayi protein C24B5.3 0.0012 0.0001 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0909 0.9735
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.026 0.0289
Brugia malayi Serotonin receptor 0.0032 0.026 0.0597
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Echinococcus granulosus cyclin dependent kinase 0.0039 0.0339 0.0778
Brugia malayi prolyl oligopeptidase family protein 0.0355 0.4359 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0026 0.0028
Schistosoma mansoni hypothetical protein 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Brugia malayi prolyl oligopeptidase family protein 0.035 0.4298 0.9861
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0145 0.0431
Loa Loa (eye worm) hypothetical protein 0.0065 0.0673 0.1544
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.026 0.0597
Trypanosoma cruzi polo-like protein kinase, putative 0.0083 0.0909 0.2113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.026 0.0289
Brugia malayi Patched related family protein 12 0.0012 0.0001 0.0002
Trichomonas vaginalis cyclin D, putative 0.0027 0.0192 0.1246
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Mycobacterium ulcerans beta-lactamase 0.0035 0.0299 0.1314
Echinococcus multilocularis cyclins 0.0027 0.0192 0.0192
Schistosoma mansoni nAChR subunit 0.0026 0.0178 0.0197
Schistosoma mansoni nAChR subunit 0.0026 0.0178 0.0197
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0178 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0381 0.3485
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0034 0.0037
Echinococcus granulosus fmrfamide receptor 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0178 0.0407
Entamoeba histolytica prolyl oligopeptidase family protein 0.0059 0.0604 0.148
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0339 0.0377
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.026 0.0597
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0225 0.2705 0.3003
Echinococcus multilocularis cyclin dependent kinase 1 0.0039 0.0339 0.0339
Echinococcus granulosus serotonin receptor 0.0032 0.026 0.0597
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.026 0.0289
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.026 0.0597
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0145 0.0334
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.026 0.0289
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0034 0.0076
Trypanosoma brucei PAB1-binding protein , putative 0.0033 0.0262 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0107 0.0246
Schistosoma mansoni nuclear hormone receptor 0.002 0.0107 0.0119
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0026 0.0059
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.026 0.026
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0178 0.0197
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.026 0.0597
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.026 0.026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0299 0.0685
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0685
Echinococcus multilocularis high affinity choline transporter 1 0.0268 0.325 0.325
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0142 0.1652 0.3795
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0034 0.0282 0.0646
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0058 0.0068
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0299 0.0755
Echinococcus multilocularis allatostatin A receptor 0.0032 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Schistosoma mansoni tyrosine kinase 0.0034 0.0274 0.0304
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0026 0.0178 0.0407
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0145 0.0305
Echinococcus multilocularis sex peptide receptor 0.0032 0.026 0.026
Brugia malayi ecdysteroid receptor 0.002 0.0107 0.0246
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.1251 0.2871
Brugia malayi Calcitonin receptor-like protein seb-1 0.0139 0.162 0.3716
Schistosoma mansoni cellular tumor antigen P53 0.0037 0.0322 0.0358
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0064 0.066 0.0733
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0026 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.026 0.0289
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0178 0.0178
Giardia lamblia Kinase, TTK 0.0064 0.066 0.1305
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Brugia malayi Cation transporter family protein 0.0173 0.2049 0.4702
Schistosoma mansoni inositol transporter 0.003 0.0223 0.0248
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0064 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Brugia malayi excitatory GABA receptor EXP-1A 0.0026 0.0178 0.0407
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0026 0.0059
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0107 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0909 0.9735
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0355 0.4359 0.4839
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.2412 0.2678
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0026 0.0178 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0107 0.0246
Echinococcus granulosus GPCR family 2 0.0044 0.0408 0.0937
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0178 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1114 0.1236
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0044 0.0408 0.0408
Giardia lamblia Kinase, PLK 0.0083 0.0909 0.1966
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0299 0.4937
Onchocerca volvulus 0.0032 0.026 0.0597
Schistosoma mansoni nAChR subunit 0.0026 0.0178 0.0197
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1114 0.2555
Echinococcus multilocularis ubiquitin specific protease 41 0.0025 0.0169 0.0169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0058 0.0068
Onchocerca volvulus 0.0032 0.026 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0091 0.1011 0.252
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0339 0.0377
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0107 0.0246
Echinococcus multilocularis neuropeptide receptor 0.0032 0.026 0.026
Echinococcus granulosus g protein coupled receptor 0.0032 0.026 0.0597
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0044 0.0408 0.0937
Trypanosoma cruzi oligopeptidase b 0.0154 0.1812 0.4215
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Brugia malayi follicle stimulating hormone receptor 0.0032 0.026 0.0597
Trichomonas vaginalis AGC family protein kinase 0.005 0.0486 0.4729
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0034 0.0075
Schistosoma mansoni tyrosine kinase 0.0034 0.0282 0.0313
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0299 0.0685
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.005 0.0486 0.0486
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0145 0.0431
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0026 0.0178 0.0407
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0142 0.1652 0.3841
Onchocerca volvulus 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0026 0.0178 0.0407
Leishmania major protein kinase, putative 0.005 0.0486 0.1128
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0909 0.9735
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Trypanosoma cruzi polo-like protein kinase, putative 0.0083 0.0909 0.2113
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.026 0.0597
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0025 0.0169 0.039
Trichomonas vaginalis AGC family protein kinase 0.005 0.0486 0.4729
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.026 0.026
Brugia malayi neuropeptide F receptor 0.0032 0.026 0.0597
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0107 0.0107
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0091 0.1011 0.252
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0127 0.0141
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0059 0.0604 0.148
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0178 0.0407
Schistosoma mansoni transcription factor LCR-F1 0.0022 0.0128 0.0142
Schistosoma mansoni cyclin B 0.0065 0.0673 0.0747
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0291 0.3542 1
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0604 0.1403
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0107 0.0246
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0027 0.0192 0.044
Schistosoma mansoni hypothetical protein 0.0047 0.0452 0.0502
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Trichomonas vaginalis cyclin B, putative 0.0065 0.0673 0.694
Echinococcus multilocularis cyclin dependent kinase 5 0.0039 0.0339 0.0339
Echinococcus multilocularis cyclins 0.0027 0.0192 0.0192
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0178 0.0197
Brugia malayi Furin-like cysteine rich region family protein 0.0034 0.0282 0.0646
Schistosoma mansoni hypothetical protein 0.0022 0.0128 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.066 0.679
Brugia malayi latrophilin 2 splice variant baaae 0.0095 0.1059 0.243
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Loa Loa (eye worm) hypothetical protein 0.0199 0.2373 0.5444
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Schistosoma mansoni opsin-like receptor 0.0032 0.026 0.0289
Trichomonas vaginalis cyclins, putative 0.0065 0.0673 0.694
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0355 0.4359 0.4359
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Mycobacterium tuberculosis Conserved protein 0.0035 0.0299 0.0755
Schistosoma mansoni neuropeptide receptor 0.0032 0.026 0.0289
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0026 0.0178 0.0407
Entamoeba histolytica cell division protein kinase 2, putative 0.0039 0.0339 0.0803
Trypanosoma brucei cdc2-related kinase 1 0.0039 0.0339 0.0717
Toxoplasma gondii ABC1 family protein 0.0035 0.0299 0.0693
Entamoeba histolytica prolyl oligopeptidase family protein 0.0059 0.0604 0.148
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0002
Echinococcus granulosus allatostatin A receptor 0.0032 0.026 0.0597
Echinococcus granulosus neuropeptide s receptor 0.0032 0.026 0.0597
Trypanosoma brucei cdc2-related kinase 3 0.0039 0.0339 0.0717
Loa Loa (eye worm) AUR protein kinase 0.005 0.0486 0.1115
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.026 0.0597
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.026 0.0597
Loa Loa (eye worm) TK/ROR protein kinase 0.0013 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0178 0.0407
Loa Loa (eye worm) LGC-31 protein 0.0026 0.0178 0.0407
Trypanosoma cruzi cdc2-related kinase 3 0.0039 0.0339 0.0786
Brugia malayi hypothetical protein 0.0033 0.0262 0.0601
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0178 0.0178
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0178 0.0197
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.026 0.026
Mycobacterium tuberculosis Conserved protein 0.0035 0.0299 0.0755
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0039 0.0339 0.0778
Echinococcus granulosus cyclins 0.0027 0.0192 0.044
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0178 0.0407
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.005 0.0486 0.1178
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.026 0.026
Echinococcus granulosus cyclin B3 1 0.0027 0.0192 0.044
Loa Loa (eye worm) hypothetical protein 0.0173 0.2049 0.4702
Echinococcus multilocularis protein patched 0.0085 0.0931 0.0931
Schistosoma mansoni histamine h1 receptor 0.0032 0.026 0.0289
Onchocerca volvulus 0.0012 0.0001 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.026 0.026
Onchocerca volvulus 0.0032 0.026 0.0597
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Onchocerca volvulus 0.003 0.0223 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0107 0.0246
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0145 0.0334
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.026 0.0597
Trypanosoma cruzi cdc2-related kinase 3 0.0039 0.0339 0.0786
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0178 0.0407
Brugia malayi MH2 domain containing protein 0.011 0.1251 0.2871
Echinococcus granulosus solute carrier family 5 0.003 0.0223 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Echinococcus granulosus cyclin B 0.0065 0.0673 0.1544
Toxoplasma gondii prolyl endopeptidase 0.035 0.4298 1
Trichomonas vaginalis cyclins, putative 0.0044 0.0412 0.3852
Onchocerca volvulus 0.0065 0.0673 0.1544
Giardia lamblia Alanyl dipeptidyl peptidase 0.0059 0.0604 0.1156
Loa Loa (eye worm) hypothetical protein 0.0037 0.0321 0.0735
Brugia malayi Kringle domain containing protein 0.0012 0.0001 0.0003
Onchocerca volvulus 0.0012 0.0001 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0299 0.0685
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0909 0.9735
Echinococcus multilocularis microsomal triglyceride transfer protein large 0.0125 0.1434 0.1434
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0107 0.0246
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.026 0.0597
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Onchocerca volvulus 0.0173 0.2049 0.4702
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0082 0.0892 0.0991
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.026 0.0289
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.026 0.0597
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Onchocerca volvulus 0.0014 0.0026 0.0059
Onchocerca volvulus 0.002 0.0107 0.0246
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0075 0.0801 0.0801
Trypanosoma brucei polo-like protein kinase 0.0083 0.0909 0.2053
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0107 0.0119
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0107 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0107 0.0246
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0169 0.0387
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0039 0.0339 0.0778
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0026 0.0178 0.0407
Giardia lamblia Kinase, CMGC CDK 0.0039 0.0339 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0107 0.0246
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0178 0.0407
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.026 0.0597
Echinococcus multilocularis g protein coupled receptor 0.0032 0.026 0.026
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.026 0.0597
Entamoeba histolytica cyclin family protein 0.0027 0.0192 0.0425
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.0604 0.1386
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus multilocularis GPCR, family 2 0.0044 0.0408 0.0408
Trypanosoma cruzi prolyl endopeptidase 0.035 0.4298 1
Echinococcus granulosus tumor protein p63 0.0255 0.3089 0.7087
Toxoplasma gondii kringle domain-containing protein 0.0012 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0192 0.1246
Schistosoma mansoni thyroid hormone receptor 0.002 0.0107 0.0119
Brugia malayi Cyclin, N-terminal domain containing protein 0.0027 0.0192 0.044
Echinococcus multilocularis cyclin b3 0.0027 0.0192 0.0192
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0145 0.0332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.026 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0909 0.9735
Giardia lamblia Kinase, CMGC CDK 0.0039 0.0339 0.0453
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.026 0.0289
Trichomonas vaginalis cyclins, putative 0.0065 0.0673 0.694
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0339 0.2991
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.026 0.0597
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0169 0.0973
Echinococcus granulosus g protein coupled receptor 0.0032 0.026 0.0597
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0339 0.2991
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.026 0.0597
Echinococcus granulosus acylamino acid releasing enzyme 0.0059 0.0604 0.1386
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0002
Schistosoma mansoni kinase 0.0043 0.0395 0.0438
Onchocerca volvulus 0.0032 0.026 0.0597
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.026 0.0289
Brugia malayi nuclear hormone receptor 0.002 0.0107 0.0246
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0059 0.0604 0.1403
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0107 0.0107
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.026 0.0597
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0026 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0685
Loa Loa (eye worm) hypothetical protein 0.0082 0.0896 0.2055
Trypanosoma brucei prolyl oligopeptidase, putative 0.0154 0.1812 0.4171
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0145 0.0431
Giardia lamblia Hypothetical protein 0.0027 0.0192 0.0061
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0026 0.0178 0.0407
Schistosoma mansoni coup transcription factor 0.002 0.0107 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0169 0.0973
Schistosoma mansoni hypothetical protein 0.0044 0.0408 0.0453
Echinococcus multilocularis protein dispatched 1 0.0097 0.1085 0.1085
Loa Loa (eye worm) prolyl oligopeptidase 0.0059 0.0604 0.1386
Brugia malayi prolyl oligopeptidase family protein 0.0142 0.1652 0.379
Echinococcus granulosus cyclin dependent kinase 5 0.0039 0.0339 0.0778
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.026 0.0597
Mycobacterium tuberculosis Probable peptidase 0.0154 0.1812 0.507
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0026 0.0178 0.0178
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus multilocularis fmrfamide receptor 0.0032 0.026 0.026
Onchocerca volvulus 0.0032 0.026 0.0597
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0299 0.0755
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0299 0.2511
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0059 0.0604 0.6124
Echinococcus multilocularis cyclins 0.0027 0.0192 0.0192
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.026 0.0289
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0083 0.0909 0.2113
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.003 0.0223 0.0512
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.2373 0.2373
Onchocerca volvulus 0.0035 0.0299 0.0685
Brugia malayi serine/threonine-protein kinase plk-2 0.0083 0.0909 0.2086
Echinococcus granulosus tissue type plasminogen activator 0.0012 0.0001 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0022 0.0128 0.0294
Leishmania major oligopeptidase b 0.0154 0.1812 0.4215
Loa Loa (eye worm) beta-lactamase 0.0035 0.0299 0.0685
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.026 0.0597
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.026 0.0597
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.026 0.0597
Schistosoma mansoni patched 1 0.0085 0.0931 0.1034
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0107 0.0119
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0103 0.0237
Schistosoma mansoni hypothetical protein 0.0082 0.0892 0.0991
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Trichomonas vaginalis cyclins, putative 0.0027 0.0192 0.1246
Echinococcus granulosus sodium:glucose cotransporter 0.003 0.0223 0.0512
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.026 0.026
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.026 0.026
Schistosoma mansoni nAChR subunit 0.0026 0.0178 0.0197
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0027 0.0192 0.0192
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0145 0.0431
Onchocerca volvulus Protein patched homolog 0.0012 0.0001 0.0002
Echinococcus granulosus Lipid transport protein N terminal 0.0071 0.0748 0.1716
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0154 0.1812 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0299 0.0923
Echinococcus multilocularis epidermal growth factor receptor 0.0034 0.0282 0.0282
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0044 0.0408 0.0453
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0173 0.2049 0.2275
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0169 0.0169
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0142 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Schistosoma mansoni hypothetical protein 0.0125 0.1434 0.1592
Loa Loa (eye worm) hypothetical protein 0.0095 0.1059 0.243
Trichomonas vaginalis AGC family protein kinase 0.005 0.0486 0.4729
Echinococcus multilocularis g protein coupled receptor 0.0032 0.026 0.026
Schistosoma mansoni myosin xvIII 0.0032 0.026 0.0289
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0931 0.2137
Mycobacterium tuberculosis Conserved protein 0.0035 0.0299 0.0755
Loa Loa (eye worm) hypothetical protein 0.0161 0.1897 0.4353
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.007 0.1139
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0026 0.0178 0.0407
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0142 0.1652 0.3841
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0299 0.0332
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.026 0.0597
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.026 0.0597
Echinococcus granulosus cyclin b3 0.0027 0.0192 0.044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0755
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0107 0.0246
Brugia malayi larval opioid receptor 0.0032 0.026 0.0597
Echinococcus granulosus sex peptide receptor 0.0032 0.026 0.0597
Trypanosoma cruzi cdc2-related kinase 1 0.0039 0.0339 0.0786
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0064 0.066 0.1515
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0685
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0107 0.0246
Trypanosoma cruzi cyclin, putative 0.0065 0.0673 0.1563
Loa Loa (eye worm) hypothetical protein 0.0173 0.2049 0.4702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1114 0.2555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1114 0.1236
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0039 0.0339 0.0778
Loa Loa (eye worm) hypothetical protein 0.0059 0.0604 0.1386
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0268 0.325 0.7457
Echinococcus multilocularis cyclins 0.0027 0.0192 0.0192
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0107 0.0246
Schistosoma mansoni hypothetical protein 0.0044 0.0408 0.0453
Trypanosoma cruzi cdc2-related kinase 1 0.0039 0.0339 0.0786
Echinococcus granulosus epidermal growth factor receptor 0.0034 0.0282 0.0646
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0673 0.1544
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Echinococcus granulosus nAChR subunit 0.0014 0.0026 0.0059
Brugia malayi Cation transporter family protein 0.0026 0.0178 0.0407
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0142 0.1652 0.3841
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Brugia malayi Cation transporter family protein 0.0026 0.0178 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0107 0.0246
Brugia malayi Dopamine receptor 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Schistosoma mansoni biogenic amine receptor 0.0032 0.026 0.0289
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0299 0.0755
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0142 0.1652 0.1834
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0039 0.0339 0.0786
Brugia malayi Protein kinase domain containing protein 0.0013 0.0009 0.0021
Echinococcus granulosus g protein coupled receptor 0.0032 0.026 0.0597
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Trichomonas vaginalis cyclin B, putative 0.0065 0.0673 0.694
Schistosoma mansoni amine GPCR 0.0032 0.026 0.0289
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0321 0.3934 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0015 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0178 0.0407
Schistosoma mansoni biogenic amine receptor 0.0032 0.026 0.0289
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0142 0.1652 0.3842
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0142 0.1652 0.3795
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0931 0.0931
Brugia malayi steroid hormone receptor 0.002 0.0107 0.0246
Onchocerca volvulus 0.0032 0.026 0.0597
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0107 0.0107
Onchocerca volvulus 0.0032 0.026 0.0597
Plasmodium vivax protein kinase Crk2 0.0039 0.0339 0.5609
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2808 0.6443
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0107 0.0246
Schistosoma mansoni amine GPCR 0.0032 0.026 0.0289
Schistosoma mansoni amine GPCR 0.0032 0.026 0.0289
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.026 0.026
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0026 0.0178 0.0407
Brugia malayi neuropeptide F receptor 0.0032 0.026 0.0597
Brugia malayi G-protein coupled receptor 0.0032 0.026 0.0597
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0173 0.2049 0.2275
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0034 0.0034
Entamoeba histolytica cyclin family protein 0.0027 0.0192 0.0425
Trypanosoma cruzi cyclin 6, putative 0.0065 0.0673 0.1563
Entamoeba histolytica prolyl oligopeptidase family protein 0.0059 0.0604 0.148
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0178 0.0407
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0044 0.0408 0.0937
Echinococcus granulosus high affinity choline transporter 1 0.0268 0.325 0.7457
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0339 0.2991
Onchocerca volvulus 0.0173 0.2049 0.4702
Schistosoma mansoni hypothetical protein 0.0044 0.0408 0.0453
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Giardia lamblia G2/mitotic-specific cyclin B 0.0065 0.0673 0.1339
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.026 0.0597
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0059 0.0604 0.148
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.026 0.026
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Onchocerca volvulus Serine\/threonine kinase homolog 0.0083 0.0909 0.2086
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2808 0.2808
Brugia malayi hypothetical protein 0.0233 0.2808 0.6443
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.016
Schistosoma mansoni neuropeptide receptor 0.0032 0.026 0.0289
Brugia malayi Patched related family protein 4 0.0012 0.0001 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.026 0.026
Plasmodium vivax serine/threonine protein kinase 6, putative 0.005 0.0486 0.8045
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.026 0.0289
Toxoplasma gondii aurora kinase 0.005 0.0486 0.1129
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.026 0.0597
Schistosoma mansoni tyrosine kinase 0.0034 0.0274 0.0304
Brugia malayi Protein kinase domain containing protein 0.0075 0.0801 0.1839
Schistosoma mansoni cyclins 0.0027 0.0192 0.0213
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Plasmodium falciparum serine/threonine protein kinase, putative 0.005 0.0486 0.8045
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0154 0.1812 0.4215
Onchocerca volvulus Putative nachr subunit 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0107 0.0246
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.026 0.0289
Schistosoma mansoni nAChR subunit 0.0026 0.0178 0.0197
Entamoeba histolytica hypothetical protein 0.0022 0.0128 0.0263
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.026 0.0597
Echinococcus multilocularis serotonin receptor 0.0032 0.026 0.026
Onchocerca volvulus 0.0173 0.2049 0.4702
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.026 0.0597
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0107 0.0119
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0107 0.0246
Plasmodium falciparum cysteine repeat modular protein 1 0.0012 0.0001 0.0005
Brugia malayi Cyclin, N-terminal domain containing protein 0.0065 0.0673 0.1544
Trichomonas vaginalis cyclin A, putative 0.0065 0.0673 0.694
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0145 0.0334
Brugia malayi CHE-14 protein 0.0085 0.0931 0.2137
Onchocerca volvulus Apolipophorins homolog 0.0071 0.0748 0.1716
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0026 0.0178 0.0407
Brugia malayi G protein-coupled receptor 0.0032 0.026 0.0597
Echinococcus granulosus g-protein coupled receptor 0.0032 0.026 0.0597
Plasmodium vivax ataxin-2 like protein, putative 0.0033 0.0262 0.433
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0034 0.0034
Schistosoma mansoni tyrosine kinase 0.0075 0.0801 0.089
Brugia malayi Myosin head containing protein 0.0012 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0025 0.0169 0.0366
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.066 0.679
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0107 0.0107
Schistosoma mansoni nAChR subunit 0.0026 0.0178 0.0197
Plasmodium falciparum protein kinase 5 0.0039 0.0339 0.5609
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0844
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0145 0.0317
Loa Loa (eye worm) AUR protein kinase 0.005 0.0486 0.1115
Brugia malayi Protein kinase domain containing protein 0.0039 0.0339 0.0778
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus multilocularis cyclin dependent kinase 0.0039 0.0339 0.0339
Brugia malayi hypothetical protein 0.0032 0.026 0.0597
Trichomonas vaginalis AGC family protein kinase 0.005 0.0486 0.4729
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.2373 0.5444
Echinococcus multilocularis acylamino acid releasing enzyme 0.0059 0.0604 0.0604
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Brugia malayi isocitrate dehydrogenase 0.0015 0.0034 0.0077
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0059
Echinococcus multilocularis epidermal growth factor receptor 0.0034 0.0282 0.0282
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.026 0.0597
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.026 0.0597
Echinococcus granulosus ubiquitin specific protease 41 0.0025 0.0169 0.0387
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.026 0.0597
Echinococcus multilocularis somatostatin receptor 0.0032 0.026 0.026
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0169 0.0387
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus multilocularis sodium:glucose cotransporter 2 0.003 0.0223 0.0223
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0178 0.0178
Echinococcus multilocularis aurora kinase A 0.005 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0107 0.0119
Brugia malayi hypothetical protein 0.0012 0.0001 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0127 0.0141
Schistosoma mansoni opsin-like receptor 0.0032 0.026 0.0289
Echinococcus granulosus cyclins 0.0027 0.0192 0.044
Toxoplasma gondii LsmAD domain-containing protein 0.0033 0.0262 0.0608
Brugia malayi cell division control protein 2 homolog 0.0039 0.0339 0.0778
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0107 0.0246
Brugia malayi Protein kinase domain containing protein 0.0064 0.066 0.1515
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.026 0.0597
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0107 0.0246
Echinococcus multilocularis orexin receptor type 2 0.0032 0.026 0.026
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0178 0.0407
Brugia malayi hypothetical protein 0.0012 0.0001 0.0002
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.035 0.4298 0.4772
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0034 0.0541
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.003 0.0223 0.0517
Entamoeba histolytica hypothetical protein 0.0022 0.0128 0.0263
Trichomonas vaginalis esterase, putative 0.0035 0.0299 0.2511
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0075 0.0801 0.1839
Giardia lamblia Cyclin A 0.0027 0.0192 0.0061
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0299 0.0299
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.026 0.0597
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0145 0.0431
Loa Loa (eye worm) hypothetical protein 0.0071 0.0748 0.1716
Echinococcus granulosus sodium:glucose cotransporter 2 0.003 0.0223 0.0512
Schistosoma mansoni high-affinity choline transporter 0.0268 0.325 0.3608
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0246
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0025 0.0169 0.0187
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus granulosus sodium:myo inositol cotransporter 0.003 0.0223 0.0512
Loa Loa (eye worm) hypothetical protein 0.0023 0.0145 0.0332
Onchocerca volvulus 0.0035 0.0299 0.0685
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.026 0.026
Echinococcus multilocularis serotonin receptor 0.0032 0.026 0.026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0107 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0107 0.0246
Schistosoma mansoni nAChR subunit 0.0026 0.0178 0.0197
Echinococcus granulosus neuropeptide receptor 0.0032 0.026 0.0597
Plasmodium falciparum cyclin 0.0027 0.0192 0.3164
Schistosoma mansoni survival motor neuron protein 0.0047 0.0452 0.0502
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0103 0.0103
Leishmania major hypothetical protein, conserved 0.0035 0.0299 0.0692
Entamoeba histolytica cyclin, putative 0.0065 0.0673 0.1656
Echinococcus multilocularis geminin 0.0225 0.2705 0.2705
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Onchocerca volvulus 0.0012 0.0001 0.0002
Brugia malayi Melatonin receptor type 1A 0.0032 0.026 0.0597
Echinococcus granulosus nAChR subunit 0.0026 0.0178 0.0407
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0178 0.0178
Onchocerca volvulus 0.0014 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0039 0.0339 0.0787
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus granulosus serine:threonine protein kinase 12 B 0.005 0.0486 0.1115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0014 0.0026 0.0028
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0026 0.0178 0.0407
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0107 0.0107
Echinococcus granulosus somatostatin receptor 0.0032 0.026 0.0597
Entamoeba histolytica protein kinase , putative 0.005 0.0486 0.1178
Loa Loa (eye worm) hypothetical protein 0.0023 0.0145 0.0332
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0407
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0597
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0931 0.2137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.026 0.0289
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0039 0.0339 0.0786
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Loa Loa (eye worm) cyclin domain-containing protein 0.0027 0.0192 0.044
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0083 0.0909 0.2086
Schistosoma mansoni cyclin B3 0.0027 0.0192 0.0213
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0107 0.0119
Echinococcus multilocularis solute carrier family 5 0.003 0.0223 0.0223
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.026 0.0289
Brugia malayi Sodium:solute symporter family protein 0.003 0.0223 0.0512
Brugia malayi Patched family protein 0.0012 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0032 0.026 0.0289
Brugia malayi hypothetical protein 0.0022 0.0128 0.0294
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.026 0.026
Schistosoma mansoni thyroid hormone receptor 0.002 0.0107 0.0119
Loa Loa (eye worm) prolyl oligopeptidase 0.0355 0.4359 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Agonist activity at human GPR109b assessed as decrease in forskolin-stimulated cAMP production by HTRF assay ChEMBL. 22435740
EC50 (functional) = 28 nM Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay ChEMBL. 22435740
Efficacy (functional) = 98 % Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assay relative to 100 uM niacin ChEMBL. 22435740

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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