Detailed information for compound 1697251

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.357 | Formula: C16H22N2O4
  • H donors: 0 H acceptors: 2 LogP: 2.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)Oc1cccc2c1CCN2CCC(=O)OC)C
  • InChi: 1S/C16H22N2O4/c1-4-17(2)16(20)22-14-7-5-6-13-12(14)8-10-18(13)11-9-15(19)21-3/h5-7H,4,8-11H2,1-3H3
  • InChiKey: LOMCJSSKKKRIAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0032 0.0249 0.0524
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0041 0.0354 0.0354
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0129 0.1351 0.1351
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0112 0.116 0.1252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0012 0.0018 0.0154
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1093 0.1093
Brugia malayi isocitrate dehydrogenase 0.0012 0.0018 0.0038
Echinococcus multilocularis neuroligin 0.0041 0.0354 0.0354
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.0325 0.2803
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0325
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0013 0.0033 0.0305
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0414 0.0414
Trichomonas vaginalis D-aminoacylase, putative 0.0129 0.1351 0.3734
Trypanosoma brucei trypanothione reductase 0.0112 0.116 0.3278
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0018 0.0053
Echinococcus granulosus Aminotransferase class III 0.0047 0.0414 0.0414
Echinococcus multilocularis carboxylesterase 5A 0.0246 0.2673 0.2673
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0013 0.0033 0.0094
Trypanosoma brucei hypothetical protein, conserved 0.0129 0.1351 0.3819
Loa Loa (eye worm) hypothetical protein 0.0308 0.3383 0.711
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0129 0.1351 0.284
Schistosoma mansoni hypothetical protein 0.0099 0.1006 0.1006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0028 0.0196 0.0542
Loa Loa (eye worm) acetylcholinesterase 1 0.0246 0.2673 0.5616
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.0325 0.0898
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.0325 0.0898
Echinococcus multilocularis thioredoxin glutathione reductase 0.0113 0.1166 0.1166
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0174 0.0365
Echinococcus multilocularis inositol monophosphatase 1 0.0031 0.0233 0.0233
Echinococcus granulosus acetylcholinesterase 0.0246 0.2673 0.2673
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0032 0.0249 0.0524
Brugia malayi Carboxylesterase family protein 0.0246 0.2673 0.5616
Onchocerca volvulus 0.0041 0.0354 0.1649
Echinococcus granulosus para nitrobenzyl esterase 0.0041 0.0354 0.0354
Brugia malayi beta-lactamase family protein 0.0129 0.1351 0.284
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0256 0.2796 0.7727
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0033 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0308 0.3383 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0041 0.0354 0.0354
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.0325 0.0919
Echinococcus granulosus inositol monophosphatase 1 0.0031 0.0233 0.0233
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0329 0.3619 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0208 0.0436
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0129 0.1351 0.1458
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.0325 0.0919
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0509 0.1439
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0402 0.0402
Onchocerca volvulus 0.0129 0.1351 0.6298
Brugia malayi glutathione reductase 0.0112 0.116 0.2438
Brugia malayi hypothetical protein 0.0123 0.1279 0.2688
Onchocerca volvulus 0.0129 0.1351 0.6298
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Trichomonas vaginalis inositol monophosphatase, putative 0.0031 0.0233 0.0644
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0013 0.0033 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0129 0.1351 0.1351
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Loa Loa (eye worm) carboxylesterase 0.0246 0.2673 0.5616
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Schistosoma mansoni hypothetical protein 0.0107 0.1093 0.1093
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0033 0.0094
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0041 0.0354 0.0382
Trichomonas vaginalis set domain proteins, putative 0.0199 0.2146 0.5929
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Plasmodium falciparum thioredoxin reductase 0.0039 0.0325 0.2803
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0013 0.0033 0.0805
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0174 0.1591
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0047 0.0414 0.0446
Mycobacterium tuberculosis Probable lipase LipD 0.0129 0.1351 0.1458
Echinococcus granulosus thioredoxin glutathione reductase 0.0113 0.1166 0.1166
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0182 0.1948 0.4093
Schistosoma mansoni hypothetical protein 0.0326 0.3586 0.3586
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0174 0.0491
Schistosoma mansoni hypothetical protein 0.0088 0.0877 0.0877
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0256 0.2796 0.3018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658
Onchocerca volvulus 0.0123 0.1279 0.5961
Toxoplasma gondii hypothetical protein 0.0052 0.0472 0.1396
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0013 0.0033 0.0094
Treponema pallidum NADH oxidase 0.0039 0.0325 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0365
Plasmodium falciparum thioredoxin reductase 0.0112 0.116 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0402 0.0846
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0033 0.0033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0365
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0256 0.2796 0.3018
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0047 0.0414 0.0869
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.0354 0.0354
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0018 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.14 0.14
Brugia malayi latrophilin 2 splice variant baaae 0.0099 0.1006 0.2114
Trichomonas vaginalis helicase, putative 0.0014 0.0043 0.012
Echinococcus multilocularis Aminotransferase class III 0.0047 0.0414 0.0414
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0898
Mycobacterium tuberculosis Carboxylesterase LipT 0.0041 0.0354 0.0382
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.0325 0.0961
Plasmodium falciparum glutathione reductase 0.0112 0.116 1
Schistosoma mansoni inositol monophosphatase 0.0031 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Brugia malayi hypothetical protein 0.0107 0.1093 0.2297
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.01 0.2423
Echinococcus granulosus ornithine aminotransferase 0.0047 0.0414 0.0414
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0397 0.1121
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0129 0.1351 0.3734
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0047 0.0414 0.1223
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0047 0.0414 0.0446
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0325 0.7859
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.0325 0.0919
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0329 0.3619 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658
Loa Loa (eye worm) beta-lactamase 0.0129 0.1351 0.284
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0174 0.048
Schistosoma mansoni survival motor neuron protein 0.0088 0.0877 0.0877
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Trichomonas vaginalis esterase, putative 0.0129 0.1351 0.3734
Trypanosoma cruzi trypanothione reductase, putative 0.0112 0.116 0.3278
Echinococcus multilocularis cpg binding protein 0.0066 0.0633 0.0633
Loa Loa (eye worm) carboxylesterase 0.0041 0.0354 0.0744
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.0354 0.0354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.0249 0.0249
Schistosoma mansoni neuroligin 3 (S09 family) 0.0041 0.0354 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Schistosoma mansoni ap endonuclease 0.0013 0.0033 0.0033
Brugia malayi beta-lactamase 0.0129 0.1351 0.284
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0013 0.0033 0.0094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.0325 0.0683
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.1613 0.4558
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0031 0.0233 0.2131
Echinococcus multilocularis dnaJ subfamily B 0.0891 1 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0018 0.0051
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0013 0.0033 0.0092
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0325
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0018 0.0018
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0414 0.1143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0043 0.012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0397 0.1121
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0246 0.2673 0.2673
Schistosoma mansoni BC026374 protein (S09 family) 0.0041 0.0354 0.0354
Onchocerca volvulus 0.0026 0.0181 0.0845
Loa Loa (eye worm) hypothetical protein 0.0099 0.1006 0.2114
Trypanosoma cruzi hypothetical protein, conserved 0.0129 0.1351 0.3819
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Brugia malayi beta-lactamase family protein 0.0129 0.1351 0.284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0919
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0018 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0249 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1613 0.4558
Onchocerca volvulus 0.0041 0.0354 0.1649
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0069 0.0069
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0033 0.0033
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0256 0.2796 0.3018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0285 0.3122 0.3369
Mycobacterium ulcerans acetylornithine aminotransferase 0.0047 0.0414 0.1143
Plasmodium vivax glutathione reductase, putative 0.0112 0.116 0.8584
Onchocerca volvulus 0.0063 0.0593 0.2763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0249 0.0249
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1093 0.1093
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0047 0.0414 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0047 0.0414 0.1143
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.01 0.0742
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0174 0.0491
Mycobacterium ulcerans beta-lactamase 0.0129 0.1351 0.3734
Schistosoma mansoni ap endonuclease 0.0013 0.0033 0.0033
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1093 0.1093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1808 0.1951
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0113 0.0113
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0039 0.0325 0.7859
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0174 0.0365
Echinococcus multilocularis microtubule associated protein 2 0.0542 0.6036 0.6036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0181 0.0181
Schistosoma mansoni cpg binding protein 0.0066 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0826 0.9267 1
Mycobacterium ulcerans hypothetical protein 0.0129 0.1351 0.3734
Trichomonas vaginalis spcc417.12 protein, putative 0.0041 0.0354 0.0978
Echinococcus multilocularis acetylcholinesterase 0.0246 0.2673 0.2673
Schistosoma mansoni cpg binding protein 0.0063 0.0593 0.0593
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0174 0.048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Mycobacterium tuberculosis Probable dehydrogenase 0.0256 0.2796 0.3018
Leishmania major hypothetical protein, conserved 0.0129 0.1351 0.3819
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0919
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0325
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Plasmodium falciparum glutathione reductase 0.0039 0.0325 0.2803
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.0249 0.0249
Schistosoma mansoni eyes absent homolog 0.0062 0.0589 0.0589
Leishmania major trypanothione reductase 0.0112 0.116 0.3278
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0047 0.0414 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0397 0.1121
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0181 0.0536
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0414 0.0414
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0402 0.0846
Mycobacterium ulcerans hypothetical protein 0.0329 0.3619 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Mycobacterium ulcerans esterase/lipase LipP 0.0129 0.1351 0.3734
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0047 0.0414 0.0446
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Echinococcus multilocularis GPCR, family 2 0.0046 0.0402 0.0402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0174 0.0188
Loa Loa (eye worm) hypothetical protein 0.0062 0.0589 0.1238
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Mycobacterium tuberculosis Probable hydrolase 0.0129 0.1351 0.1458
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0018 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0129 0.1351 0.3734
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0325 0.0919
Toxoplasma gondii ABC1 family protein 0.0129 0.1351 0.3994
Mycobacterium tuberculosis Conserved protein 0.0129 0.1351 0.1458
Onchocerca volvulus 0.0041 0.0354 0.1649
Trypanosoma cruzi hypothetical protein, conserved 0.0129 0.1351 0.3819
Toxoplasma gondii exonuclease III APE 0.0013 0.0033 0.0098
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0208 0.0436
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0181 0.0181
Giardia lamblia NADH oxidase lateral transfer candidate 0.0039 0.0325 0.0961
Plasmodium vivax ornithine aminotransferase, putative 0.0047 0.0414 0.3062
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0069 0.0069
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Loa Loa (eye worm) inositol-1 0.0031 0.0233 0.049
Toxoplasma gondii thioredoxin reductase 0.0112 0.116 0.3428
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0041 0.0354 0.0354
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0402 0.0402
Mycobacterium ulcerans hypothetical protein 0.0026 0.0174 0.048
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Schistosoma mansoni hypothetical protein 0.0326 0.3586 0.3586
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0031 0.0233 0.0689
Plasmodium vivax thioredoxin reductase, putative 0.0112 0.116 0.8584
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0069 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0174 0.048
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Treponema pallidum exodeoxyribonuclease (exoA) 0.0013 0.0033 0.1025
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.011 0.0231
Brugia malayi follicle stimulating hormone receptor 0.0182 0.1948 0.4093
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0012 0.0018 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0129 0.1351 0.3734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0249 0.0249
Echinococcus granulosus GPCR family 2 0.0046 0.0402 0.0402
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0033 0.0247
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Echinococcus multilocularis geminin 0.0326 0.3586 0.3586
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.0249 0.0249
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0028 0.0196 0.0212
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.0325 0.2406
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.3538 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1613 0.4558
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Schistosoma mansoni inositol monophosphatase 0.0031 0.0233 0.0233
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0174 0.1591
Onchocerca volvulus 0.0041 0.0354 0.1649
Mycobacterium ulcerans hypothetical protein 0.0169 0.1808 0.4996
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0174 0.1591
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0047 0.0414 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0041 0.0354 0.0382
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0593 0.1246
Echinococcus granulosus cpg binding protein 0.0066 0.0633 0.0633
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0414 0.1143
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0047 0.0414 0.1143
Loa Loa (eye worm) hypothetical protein 0.0246 0.2673 0.5616
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0285 0.3122 0.8625
Loa Loa (eye worm) carboxylesterase 0.0041 0.0354 0.0744
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Plasmodium vivax SET domain protein, putative 0.0026 0.0181 0.1342
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0233 0.0644
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.01 0.0108
Schistosoma mansoni acetylcholinesterase 0.0041 0.0354 0.0354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0181 0.0181
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0402 0.0846
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0129 0.1351 0.1458
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.3538 1
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0325 0.0919
Mycobacterium ulcerans L-lysine aminotransferase 0.0047 0.0414 0.1143
Loa Loa (eye worm) hypothetical protein 0.0123 0.1279 0.2688
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.0325 0.0351
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.3538 1
Brugia malayi Pre-SET motif family protein 0.0175 0.1873 0.3936
Mycobacterium tuberculosis Probable oxidoreductase 0.0285 0.3122 0.3369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Echinococcus granulosus beta LACTamase domain containing family member 0.0129 0.1351 0.1351
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0129 0.1351 0.1458
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0174 0.048
Mycobacterium ulcerans carboxylesterase, LipT 0.0041 0.0354 0.0978
Schistosoma mansoni microtubule-associated protein tau 0.0542 0.6036 0.6036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.0325 0.0898
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.01 0.0864
Brugia malayi Carboxylesterase family protein 0.0246 0.2673 0.5616
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0329 0.3619 0.3906
Brugia malayi hypothetical protein 0.0429 0.4759 1
Loa Loa (eye worm) glutathione reductase 0.0112 0.116 0.2438
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Onchocerca volvulus 0.0129 0.1351 0.6298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0145 0.1526 0.3207
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Loa Loa (eye worm) hypothetical protein 0.0246 0.2673 0.5616
Loa Loa (eye worm) hypothetical protein 0.0026 0.0181 0.0381
Echinococcus multilocularis acetylcholinesterase 0.0246 0.2673 0.2673
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0174 0.0491
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0174 0.0188
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0043 0.012
Onchocerca volvulus 0.0088 0.0877 0.4087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0041 0.0354 0.0978
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0047 0.0414 0.1143
Mycobacterium tuberculosis Probable lipase LipE 0.0129 0.1351 0.1458
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0129 0.1351 0.3734
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.0325 0.0961
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Brugia malayi Inositol-1 0.0031 0.0233 0.049
Loa Loa (eye worm) hypothetical protein 0.0429 0.4759 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0018 0.0018
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Echinococcus granulosus geminin 0.0326 0.3586 0.3586
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0069 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0129 0.1351 0.3734
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0402 0.0402
Brugia malayi hypothetical protein 0.0062 0.0589 0.1238
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0047 0.0414 0.1143
Mycobacterium tuberculosis Conserved protein 0.0129 0.1351 0.1458
Echinococcus granulosus carboxylesterase 5A 0.0246 0.2673 0.2673
Loa Loa (eye worm) hypothetical protein 0.0145 0.1526 0.3207
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0365
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0174 0.048
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0256 0.2796 0.3018
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0088 0.0877 0.1843
Onchocerca volvulus 0.0199 0.2146 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0018 0.0051
Echinococcus granulosus survival motor neuron protein 1 0.0429 0.4759 0.4759
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0402 0.0846
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0325 0.7859
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0047 0.0414 0.1143
Loa Loa (eye worm) thioredoxin reductase 0.0112 0.116 0.2438
Mycobacterium tuberculosis Probable reductase 0.0256 0.2796 0.3018
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0308 0.3383 0.3383
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0325 0.0919
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0047 0.0414 0.0414
Mycobacterium leprae conserved hypothetical protein 0.0129 0.1351 0.3734
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.01 0.0277
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.0354 0.0354
Echinococcus granulosus BC026374 protein S09 family 0.0041 0.0354 0.0354
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.0325 0.2406
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0174 0.048
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0308 0.3383 0.711
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0012 0.0018 0.0132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0033 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0129 0.1351 0.1351
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0174 0.048
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0174 0.048
Schistosoma mansoni hypothetical protein 0.0891 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0033 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0181 0.0181
Mycobacterium leprae Probable lipase LipE 0.0129 0.1351 0.3734
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Brugia malayi Calcitonin receptor-like protein seb-1 0.0145 0.1526 0.3207
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0145 0.1526 0.3207
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0113 0.0113
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0031 0.0233 0.0644
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.0325 0.2803
Mycobacterium tuberculosis Conserved protein 0.0129 0.1351 0.1458
Loa Loa (eye worm) hypothetical protein 0.0062 0.0589 0.1238
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.0325 0.0898
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Mycobacterium tuberculosis Probable aminotransferase 0.0329 0.3619 0.3906
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658
Plasmodium falciparum ornithine aminotransferase 0.0047 0.0414 0.3567
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.1239 0.3661
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Mycobacterium ulcerans lipase LipD 0.0129 0.1351 0.3734
Brugia malayi CXXC zinc finger family protein 0.0063 0.0593 0.1246
Mycobacterium tuberculosis Probable esterase LipL 0.0129 0.1351 0.1458
Echinococcus granulosus neuroligin 0.0041 0.0354 0.0354
Echinococcus multilocularis survival motor neuron protein 1 0.0429 0.4759 0.4759
Brugia malayi hypothetical protein 0.0041 0.0354 0.0744
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0012 0.0018 0.0051
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0033 0.007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0175 0.1873 0.3936
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0181 0.0181
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0233 0.0644
Brugia malayi Thioredoxin reductase 0.0112 0.116 0.2438
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0013 0.0033 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.0249 0.0249
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0033 0.0092
Brugia malayi Pre-SET motif family protein 0.0026 0.0181 0.0381
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0174 0.0365
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0031 0.0233 0.5631
Schistosoma mansoni gliotactin 0.0041 0.0354 0.0354
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0174 0.048
Onchocerca volvulus 0.0026 0.0174 0.081
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0285 0.3122 0.3369
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0012 0.0018 0.0019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.0325 0.0919
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Loa Loa (eye worm) histone methyltransferase 0.002 0.0113 0.0237
Echinococcus multilocularis para nitrobenzyl esterase 0.0041 0.0354 0.0354
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0397 0.1121
Echinococcus granulosus microtubule associated protein 2 0.0542 0.6036 0.6036
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0181 0.0181
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0308 0.3383 0.711
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0018 0.0051
Schistosoma mansoni cpg binding protein 0.0066 0.0633 0.0633
Plasmodium vivax hypothetical protein, conserved 0.0129 0.1351 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.3538 1
Onchocerca volvulus 0.0041 0.0354 0.1649
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0329 0.3619 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0308 0.3383 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0129 0.1351 0.284
Echinococcus granulosus acetylcholinesterase 0.0246 0.2673 0.2673
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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