TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 515.618 | Formula: C31H34FN3O3
H donors: 1 H acceptors: 3 LogP: 4.03 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCN(C(=O)C1=C(C)N(C(=O)C(C1)CC(=O)NCc1cccc2c1cccc2)Cc1ccc(cc1)F)CC
InChi: 1S/C31H34FN3O3/c1-4-34(5-2)31(38)28-17-25(30(37)35(21(28)3)20-22-13-15-26(32)16-14-22)18-29(36)33-19-24-11-8-10-23-9-6-7-12-27(23)24/h6-16,25H,4-5,17-20H2,1-3H3,(H,33,36)
InChiKey: NGAGDOGYFDUGRF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0041	0.0275	0.182
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0139	0.0152
Plasmodium falciparum	plasmepsin I	0.0131	0.1044	0.3599
Onchocerca volvulus		0.0072	0.0538	0.0549
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.151	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0022	0.011	0.0104
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.011	0.0158
Schistosoma mansoni	hypothetical protein	0.1025	0.871	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0012	0.0023	0.0033
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0139	0.0133
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0139	0.0917
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.0139	0.0198
Plasmodium falciparum	plasmepsin IX	0.0031	0.0187	0.0018
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0139	0.0152
Onchocerca volvulus	Putative nachr subunit	0.0022	0.011	0.0105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0006	0.0039
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0139	0.0133
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0022	0.011	0.0104
Echinococcus granulosus	glycine receptor subunit beta	0.0022	0.011	0.012
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0041	0.0275	0.0309
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0139	0.0917
Onchocerca volvulus		0.0072	0.0538	0.0549
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0065	0.0432
Brugia malayi	Cation transporter family protein	0.0022	0.011	0.0158
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0131	0.1044	0.1193
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0022	0.011	0.0104
Schistosoma mansoni	opsin-like receptor	0.0025	0.0139	0.0152
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.011	0.0158
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.011	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0022	0.0113	0.0107
Schistosoma mansoni	hypothetical protein	0.0025	0.0139	0.0152
Brugia malayi	Smad1	0.001	0.0006	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0275	0.182
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0022	0.011	0.0104
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.001	0.0009	0.0003
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0139	0.0152
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0139	0.0133
Loa Loa (eye worm)	Smad1	0.001	0.0006	0.0039
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0139	0.0133
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0022	0.011	0.012
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0022	0.011	0.012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0139	0.0152
Schistosoma mansoni	acetylcholine receptor subunit beta	0.001	0.0009	0.0003
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0139	0.0152
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.001	0.0009	0.0003
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0012	0.0023	0.002
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0139	0.0133
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0017	0.0068	0.0449
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0022	0.011	0.012
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0006	0.0039
Onchocerca volvulus		0.0025	0.0139	0.0135
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.001	0.0009	0.0012
Brugia malayi	sulfakinin receptor protein	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Brugia malayi	MH2 domain containing protein	0.001	0.0006	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	cathepsin D (A01 family)	0.0233	0.1919	0.2198
Schistosoma mansoni	neurotransmitter gated ion channel	0.0012	0.0023	0.002
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.001	0.0009	0.0012
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	acetylcholine receptor-related	0.001	0.0009	0.0003
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.011	0.0158
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0139	0.0917
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0139	0.0152
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.001	0.0009	0.0012
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	nAChR subunit	0.0022	0.011	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0068	0.0449
Schistosoma mansoni	hypothetical protein	0.0143	0.1148	0.1312
Echinococcus multilocularis	glycine receptor subunit beta	0.0022	0.011	0.0104
Brugia malayi	hypothetical protein	0.002	0.009	0.0129
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0022	0.011	0.0158
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Onchocerca volvulus		0.0025	0.0139	0.0135
Echinococcus granulosus	somatostatin receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0022	0.011	0.0104
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0023	0.0122	1
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0139	0.0152
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0139	0.0133
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Onchocerca volvulus		0.0025	0.0139	0.0135
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.011	0.0158
Onchocerca volvulus		0.0025	0.0139	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1044	0.6916
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0139	0.0917
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Onchocerca volvulus		0.0031	0.0187	0.0185
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.0139	0.0135
Plasmodium vivax	aspartyl proteinase, putative	0.0031	0.0187	0.0018
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0022	0.011	0.0729
Plasmodium falciparum	plasmepsin V	0.0031	0.0187	0.0018
Loa Loa (eye worm)	LGC-31 protein	0.0022	0.011	0.0729
Brugia malayi	G protein-coupled receptor	0.0025	0.0139	0.0198
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0022	0.011	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0139	0.0152
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0023	0.0122	0.0116
Schistosoma mansoni	amine GPCR	0.0025	0.0139	0.0152
Schistosoma mansoni	lamin	0.0017	0.0068	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0014	0.0039	0.0033
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0139	0.0152
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.001	0.0009	0.0012
Trichomonas vaginalis	glucosylceramidase, putative	0.0122	0.0964	0.6229
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0023	0.0122	0.0116
Schistosoma mansoni	hypothetical protein	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Onchocerca volvulus		0.0012	0.0023	0.0015
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0139	0.0152
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.0139	0.0198
Plasmodium falciparum	plasmepsin VII	0.0031	0.0187	0.0018
Loa Loa (eye worm)	intermediate filament protein	0.0017	0.0068	0.0449
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0139	0.0152
Brugia malayi	Melatonin receptor type 1A	0.0025	0.0139	0.0198
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.151	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0139	0.0152
Plasmodium falciparum	plasmepsin VI	0.0131	0.1044	0.3599
Schistosoma mansoni	neurotransmitter gated ion channel	0.001	0.0009	0.0003
Plasmodium vivax	aspartyl protease, putative	0.0031	0.0187	0.0018
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0022	0.011	0.0104
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.031	0.2577	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0072	0.0538	0.0611
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0139	0.0133
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0139	0.0133
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0139	0.0133
Leishmania major	hypothetical protein, conserved	0.003	0.0183	0.0247
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0139	0.0152
Loa Loa (eye worm)	histone methyltransferase	0.0022	0.0113	0.0746
Brugia malayi	Pepsin A precursor	0.0031	0.0187	0.0268
Onchocerca volvulus		0.0025	0.0139	0.0135
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0139	0.0152
Brugia malayi	Cation transporter family protein	0.0022	0.011	0.0158
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	dnaJ subfamily B	0.1025	0.871	0.871
Loa Loa (eye worm)	acetylcholine receptor protein	0.001	0.0009	0.0057
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.001	0.0009	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.1134	0.9643	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0022	0.011	0.0158
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Schistosoma mansoni	amine GPCR	0.0025	0.0139	0.0152
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0153	0.1231	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	cathepsin D (A01 family)	0.0233	0.1919	0.2198
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0031	0.0187	0.0268
Brugia malayi	MH1 domain containing protein	0.001	0.0006	0.0009
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0022	0.011	0.0158
Brugia malayi	hypothetical protein	0.001	0.0009	0.0012
Brugia malayi	RE15519p	0.0025	0.0139	0.0198
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0131	0.1044	0.1193
Onchocerca volvulus		0.0025	0.0139	0.0135
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0109	0.0855	0.5661
Plasmodium falciparum	plasmepsin II	0.0131	0.1044	0.3599
Echinococcus multilocularis	GPCR, family 2	0.0041	0.0275	0.0269
Trichomonas vaginalis	glucosylceramidase, putative	0.0122	0.0964	0.6229
Schistosoma mansoni	hypothetical protein	0.0041	0.0275	0.0309
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0139	0.0152
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0022	0.0113	0.0123
Schistosoma mansoni	amine GPCR	0.0025	0.0139	0.0152
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0139	0.0133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0109	0.0855	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Brugia malayi	Dopamine receptor protein 1	0.0025	0.0139	0.0198
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Onchocerca volvulus		0.0025	0.0139	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0122	0.0418
Brugia malayi	aspartic protease BmAsp-2, identical	0.0031	0.0187	0.0268
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0139	0.0133
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0139	0.0152
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0041	0.0275	0.0309
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0022	0.011	0.0104
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0022	0.011	0.0158
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.001	0.0009	0.0003
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0022	0.011	0.0729
Leishmania major	telomerase reverse transcriptase, putative	0.031	0.2577	1
Echinococcus granulosus	geminin	0.0143	0.1148	0.1312
Onchocerca volvulus		0.0072	0.0539	0.055
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0139	0.0133
Brugia malayi	hypothetical protein	0.001	0.0009	0.0012
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Brugia malayi	putative neuropeptide receptor	0.0025	0.0139	0.0198
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0139	0.0152
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0139	0.0152
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Echinococcus multilocularis	G protein coupled receptor 139	0.0888	0.7533	0.7532
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0014	0.0039	0.0038
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0023	0.0122	0.0133
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0139	0.0133
Echinococcus granulosus	neuropeptide receptor	0.0888	0.7533	0.8647
Brugia malayi	hypothetical protein	0.0031	0.0187	0.0268
Toxoplasma gondii	aspartyl protease ASP3	0.0031	0.0187	0.0018
Trichomonas vaginalis	glucosylceramidase, putative	0.0122	0.0964	0.6229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0139	0.0133
Onchocerca volvulus		0.0031	0.0187	0.0185
Echinococcus granulosus	sex peptide receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	neuropeptide receptor	0.0888	0.7533	0.7532
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Schistosoma mansoni	hypothetical protein	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0685	0.4534
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0139	0.0152
Brugia malayi	larval opioid receptor	0.0025	0.0139	0.0198
Schistosoma mansoni	nAChR subunit	0.001	0.0009	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0139	0.0152
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.001	0.0009	0.0003
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.011	0.0158
Loa Loa (eye worm)	hypothetical protein	0.003	0.0183	0.121
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1158	0.7667
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0023	0.0122	0.0133
Brugia malayi	excitatory GABA receptor EXP-1A	0.0022	0.011	0.0158
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0139	0.0152
Plasmodium vivax	aspartyl proteinase, putative	0.0131	0.1044	0.3599
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0139	0.0152
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0139	0.0133
Brugia malayi	Serotonin receptor	0.0025	0.0139	0.0198
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Onchocerca volvulus		0.0025	0.0139	0.0135
Brugia malayi	F/Y-rich N-terminus family protein	0.0022	0.011	0.0158
Onchocerca volvulus	Glucosylceramidase homolog	0.0122	0.0964	0.0991
Schistosoma mansoni	opsin-like receptor	0.0025	0.0139	0.0152
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.011	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.0139	0.0133
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0018	0.0075	0.0069
Schistosoma mansoni	hypothetical protein	0.0041	0.0275	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	hypothetical protein	0.0025	0.0139	0.0152
Echinococcus granulosus	GPCR family 2	0.0041	0.0275	0.0309
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0185	0.151	0.2161
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0022	0.011	0.0729
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Onchocerca volvulus		0.0025	0.0139	0.0135
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0022	0.011	0.0729
Schistosoma mansoni	amine GPCR	0.0025	0.0139	0.0152
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Schistosoma mansoni	nAChR subunit	0.001	0.0009	0.0003
Brugia malayi	intermediate filament protein	0.0017	0.0068	0.0097
Brugia malayi	G-protein coupled receptor	0.0025	0.0139	0.0198
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0136	0.1091	0.3793
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.011	0.0158
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0012	0.0023	0.0033
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0139	0.0917
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0139	0.0152
Onchocerca volvulus		0.0025	0.0139	0.0135
Echinococcus granulosus	glycine receptor subunit beta	0.0022	0.011	0.012
Plasmodium vivax	plasmepsin V, putative	0.0031	0.0187	0.0018
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0185	0.151	1
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0022	0.011	0.0104
Toxoplasma gondii	aspartyl protease ASP1	0.0131	0.1044	0.3599
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.0139	0.0198
Plasmodium vivax	aspartyl protease, putative	0.0031	0.0187	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	neuropeptide receptor	0.0888	0.7533	0.8647
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Brugia malayi	MH1 domain containing protein	0.001	0.0006	0.0009
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0023	0.0122	0.0418
Plasmodium falciparum	plasmepsin VIII, putative	0.0031	0.0187	0.0018
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.0139	0.0135
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.151	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.011	0.012
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	aspartyl protease 6	0.0031	0.0187	0.1239
Trypanosoma brucei	telomerase reverse transcriptase	0.031	0.2577	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0131	0.1044	0.1039
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0139	0.0152
Echinococcus granulosus	nAChR subunit	0.0022	0.011	0.012
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0022	0.011	0.012
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	lamin	0.0017	0.0068	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	nAChR subunit	0.0022	0.011	0.012
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0072	0.0539	0.3568
Onchocerca volvulus		0.0025	0.0139	0.0135
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0538	0.3563
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Onchocerca volvulus		0.0022	0.011	0.0105
Trichomonas vaginalis	glucosylceramidase, putative	0.0122	0.0964	0.6229
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus granulosus	hypothetical protein	0.0025	0.0139	0.0152
Schistosoma mansoni	memapsin-2 (A01 family)	0.0031	0.0187	0.0208
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0023	0.0122	0.0175
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0139	0.0133
Schistosoma mansoni	hypothetical protein	0.0143	0.1148	0.1312
Schistosoma mansoni	amine GPCR	0.0025	0.0139	0.0152
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.151	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0187	0.1239
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0139	0.0917
Schistosoma mansoni	nAChR subunit	0.0022	0.011	0.012
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0139	0.0133
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0126	0.1002	0.1031
Brugia malayi	MH2 domain containing protein	0.0144	0.1158	0.1657
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0109	0.0855	0.0975
Schistosoma mansoni	nAChR subunit	0.0022	0.011	0.012
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0538	0.3563
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Loa Loa (eye worm)	ACC-1 protein	0.0022	0.011	0.0729
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0022	0.011	0.012
Onchocerca volvulus		0.0025	0.0139	0.0135
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	opsin-like receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	nAChR subunit	0.0022	0.011	0.012
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0139	0.0917
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.0139	0.0198
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.013	0.1038	0.6872
Schistosoma mansoni	hypothetical protein	0.0041	0.0275	0.0309
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	lamin dm0	0.0017	0.0068	0.0062
Brugia malayi	Dopamine receptor protein 2	0.0025	0.0139	0.0198
Echinococcus granulosus	dnaJ subfamily B	0.1025	0.871	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0139	0.0152
Brugia malayi	Serotonin receptor	0.0025	0.0139	0.0198
Onchocerca volvulus		0.0025	0.0139	0.0135
Brugia malayi	Intermediate filament tail domain containing protein	0.0017	0.0068	0.0097
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	musashi	0.0017	0.0068	0.0062
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0022	0.011	0.0729
Schistosoma mansoni	lamin	0.0017	0.0068	0.0071
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0022	0.011	0.012
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0139	0.0152
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0139	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0154
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0139	0.0152
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0131	0.1044	0.6785
Plasmodium falciparum	plasmepsin III	0.0031	0.0187	0.0018
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0023	0.0122	0.0133
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0109	0.0855	0.0975
Echinococcus granulosus	ubiquitin specific protease 41	0.0023	0.0122	0.0133
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0139	0.0917
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0139	0.0152
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0041	0.0275	0.0393
Schistosoma mansoni	hypothetical protein	0.0089	0.0685	0.078
Plasmodium falciparum	plasmepsin X	0.0031	0.0187	0.0018
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Plasmodium vivax	telomerase reverse transcriptase, putative	0.031	0.2577	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0022	0.011	0.0729
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Echinococcus granulosus	nAChR subunit	0.0012	0.0023	0.002
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Schistosoma mansoni	adenoreceptor	0.0025	0.0139	0.0152
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Echinococcus multilocularis	serotonin receptor	0.0025	0.0139	0.0133
Echinococcus multilocularis	nAChR subunit	0.0012	0.0023	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0122	0.0808
Brugia malayi	neuropeptide F receptor	0.0025	0.0139	0.0198
Schistosoma mansoni	cpg binding protein	0.0072	0.0539	0.0612
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0183	0.0247
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0183	0.0247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Onchocerca volvulus		0.0025	0.0139	0.0135
Schistosoma mansoni	nAChR subunit	0.0022	0.011	0.012
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0139	0.0152
Echinococcus granulosus	serotonin receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0139	0.0133
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.001	0.0009	0.0012
Loa Loa (eye worm)	hypothetical protein	0.013	0.1038	0.6872
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0139	0.0152
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.0139	0.0198
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.151	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0031	0.0187	0.0208
Toxoplasma gondii	aspartyl protease	0.0031	0.0187	0.0018
Brugia malayi	ORL1-like opioid receptor	0.0025	0.0139	0.0198
Echinococcus multilocularis	ubiquitin specific protease 41	0.0023	0.0122	0.0116
Schistosoma mansoni	neurotransmitter gated ion channel	0.001	0.0009	0.0003
Onchocerca volvulus		0.0022	0.011	0.0105
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0022	0.011	0.0158
Schistosoma mansoni	myosin xvIII	0.0025	0.0139	0.0152
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.001	0.0009	0.0012
Brugia malayi	CXXC zinc finger family protein	0.0072	0.0539	0.0771
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0109	0.0855	0.0849
Brugia malayi	MH2 domain containing protein	0.001	0.0006	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0139	0.0152
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0139	0.0152
Schistosoma mansoni	cpg binding protein	0.0076	0.0574	0.0653
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0022	0.011	0.0158
Trichomonas vaginalis	glucosylceramidase, putative	0.0128	0.102	0.6617
Echinococcus granulosus	intermediate filament protein	0.0017	0.0068	0.0071
Loa Loa (eye worm)	GABA receptor subunit	0.0012	0.0023	0.0154
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Brugia malayi	hypothetical protein	0.003	0.0183	0.0261
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.0139	0.0198
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0023	0.0122	0.0133
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0022	0.011	0.012
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0139	0.0152
Brugia malayi	Cation transporter family protein	0.0072	0.0538	0.077
Onchocerca volvulus		0.0012	0.0023	0.0015
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0131	0.1044	0.3599
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Brugia malayi	Calcitonin receptor-like protein seb-1	0.013	0.1038	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0109	0.0855	0.1223
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.011	0.012
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0187	0.1239
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0139	0.0133
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0139	0.0152
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0198
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	serotonin receptor	0.0025	0.0139	0.0133
Schistosoma mansoni	hypothetical protein	0.0041	0.0275	0.0309
Brugia malayi	latrophilin 2 splice variant baaae	0.0089	0.0685	0.098
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0139	0.0133
Onchocerca volvulus		0.0017	0.0068	0.0061
Onchocerca volvulus		0.0025	0.0139	0.0135
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0022	0.011	0.012
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1158	0.7667
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	nAChR subunit	0.0022	0.011	0.012
Echinococcus granulosus	lamin	0.0017	0.0068	0.0071
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0139	0.0133
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0139	0.0152
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0139	0.0152
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0131	0.1044	0.6916
Plasmodium vivax	aspartyl protease, putative	0.0031	0.0187	0.0018
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.011	0.012
Trichomonas vaginalis	glucosylceramidase, putative	0.0122	0.0964	0.6229
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0022	0.011	0.012
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.013	0.1038	0.1485
Brugia malayi	hypothetical protein	0.001	0.0009	0.0012
Brugia malayi	Dopamine receptor	0.0025	0.0139	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Brugia malayi	GnHR receptor homolog	0.0025	0.0139	0.0198
Loa Loa (eye worm)	ACC-1 protein	0.0022	0.011	0.0729
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.001	0.001	0.0005
Giardia lamblia	Telomerase catalytic subunit	0.031	0.2577	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0039	0.0038
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0022	0.011	0.012
Onchocerca volvulus		0.0017	0.0068	0.0061
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0139	0.0152
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0139	0.0133
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0012	0.0023	0.002
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1002	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0139	0.0152
Brugia malayi	hypothetical protein	0.0031	0.0187	0.0268
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0041	0.0275	0.0269
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0075	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.001	0.0009	0.0003
Echinococcus granulosus	lamin dm0	0.0017	0.0068	0.0071
Brugia malayi	N-terminal motif family protein	0.0126	0.1002	0.1434
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0183	0.0247
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0057
Onchocerca volvulus		0.0025	0.0139	0.0135
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0018	0.0075	0.0079
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.151	1
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0139	0.0133
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0022	0.011	0.012
Brugia malayi	Latrophilin receptor protein 2	0.0041	0.0275	0.0393
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0022	0.011	0.0104
Onchocerca volvulus		0.0022	0.011	0.0105
Brugia malayi	neuropeptide F receptor	0.0025	0.0139	0.0198
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.001	0.0009	0.0057
Trichomonas vaginalis	glucosylceramidase, putative	0.0128	0.102	0.6617
Brugia malayi	hypothetical protein	0.001	0.0009	0.0012
Brugia malayi	hypothetical protein	0.001	0.0009	0.0012
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0139	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0451	0.2987
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0139	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0012	0.0023	0.0033
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0012	0.0023	0.0033
Schistosoma mansoni	cpg binding protein	0.0076	0.0574	0.0653
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0109	0.0855	0.0849
Toxoplasma gondii	RNA-directed DNA polymerase	0.031	0.2577	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Echinococcus multilocularis	glycine receptor subunit beta	0.0022	0.011	0.0104
Brugia malayi	G-protein coupled receptor	0.0025	0.0139	0.0198
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0031	0.0187	0.0018
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0139	0.0152
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0109	0.0855	0.0975
Schistosoma mansoni	nAChR subunit	0.0022	0.011	0.012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0139	0.0152
Brugia malayi	aspartic protease BmAsp-1, identical	0.0031	0.0187	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0139	0.0133
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0139	0.0133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0109	0.0855	0.0975
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0139	0.0917
Brugia malayi	AKH receptor	0.0025	0.0139	0.0198
Echinococcus granulosus	cpg binding protein	0.0076	0.0574	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0072	0.0538	0.0611
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.031	0.2577	1
Schistosoma mansoni	intermediate filament proteins	0.0017	0.0068	0.0071
Plasmodium falciparum	plasmepsin IV	0.0131	0.1044	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0022	0.011	0.012
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0041	0.0275	0.0269
Echinococcus multilocularis	cpg binding protein	0.0076	0.0574	0.0568
Onchocerca volvulus		0.0072	0.0538	0.0549
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0139	0.0917
Trichomonas vaginalis	glucosylceramidase, putative	0.0122	0.0964	0.6229
Onchocerca volvulus		0.0025	0.0139	0.0135
Plasmodium vivax	plasmepsin IV, putative	0.0131	0.1044	0.3599
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.011	0.0158
Brugia malayi	Telomerase reverse transcriptase	0.0824	0.6988	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.011	0.0729
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0075	0.0079
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0023	0.0122	0.0418
Echinococcus multilocularis	geminin	0.0143	0.1148	0.1143
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0139	0.0133
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.0139	0.0198
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0022	0.011	0.0158
Plasmodium falciparum	telomerase reverse transcriptase	0.031	0.2577	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0139	0.0152
Trichomonas vaginalis	glucosylceramidase, putative	0.0122	0.0964	0.6229
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0031	0.0187	0.1239
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0018	0.0075	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0917

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2140517

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1703275