Detailed information for compound 172864

Basic information

Technical information
  • TDR Targets ID: 172864
  • Name: 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hyd roxy-2-phenylacetate hydrochloride
  • MW: 393.947 | Formula: C22H32ClNO3
  • H donors: 1 H acceptors: 2 LogP: 4.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC.Cl
  • InChi: 1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H
  • InChiKey: SWIJYDAEGSIQPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-acetate hydrochloride
  • 2-cyclohexyl-2-hydroxy-2-phenylacetic acid 4-(diethylamino)but-2-ynyl ester hydrochloride
  • 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate hydrochloride
  • 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 4-(diethylamino)but-2-ynyl ester hydrochloride
  • 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; hydron; chloride
  • 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-acetate; hydron; chloride
  • 2-cyclohexyl-2-hydroxy-2-phenylacetic acid 4-(diethylamino)but-2-ynyl ester; hydron; chloride
  • 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate; hydron; chloride
  • 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 4-(diethylamino)but-2-ynyl ester; hydron; chloride
  • 4-(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxybut-2-ynyl-diethylazanium chloride
  • 4-(2-cyclohexyl-2-hydroxy-2-phenyl-acetyl)oxybut-2-ynyl-diethyl-ammonium chloride
  • 4-(2-cyclohexyl-2-hydroxy-1-oxo-2-phenylethoxy)but-2-ynyl-diethylammonium chloride
  • 4-(2-cyclohexyl-2-hydroxy-2-phenyl-ethanoyl)oxybut-2-ynyl-diethyl-azanium chloride
  • oxybutynin
  • 4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; hydron; chloride
  • 4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride
  • 4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-acetate; hydron; chloride
  • 4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-acetate hydrochloride
  • 2-cyclohexyl-2-hydroxy-2-phenylacetic acid 4-diethylaminobut-2-ynyl ester; hydron; chloride
  • 2-cyclohexyl-2-hydroxy-2-phenylacetic acid 4-diethylaminobut-2-ynyl ester hydrochloride
  • 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 4-diethylaminobut-2-ynyl ester; hydron; chloride
  • 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 4-diethylaminobut-2-ynyl ester hydrochloride
  • 4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate; hydron; chloride
  • 4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate hydrochloride
  • 1508-65-2
  • Prestwick_621
  • MLS000069688
  • SMR000058490
  • O2881_SIAL
  • Dridase
  • O5015_SIAL
  • EU-0100923
  • D00722
  • Ditropan
  • Ditropan (TN)
  • Oxybutynin chloride
  • Oxybutynin chloride (USP)
  • Oxybutynin hydrochloride (JAN)
  • 4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolate hydrochloride
  • 4-(Diethylamino)but-2-ynyl cyclohexylphenylglycolate hydrochloride
  • 4-Diethylamino-2-butynyl phenyl(cyclohexyl)glycolate hydrochloride
  • Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl ester hydrochloride
  • Cyclohexaneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester, hydrochloride
  • Oxybutynin hydrochloride
  • EINECS 216-139-7
  • MJ 4309-1
  • Oxibutinina hydrochloride
  • Oxybutynin chloride [USAN]
  • Tropax
  • alpha-Phenylcyclohexaneglycolic acid 4-(diethylamino)-2-butynyl ester hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.046 0.046
Toxoplasma gondii cathepsin CPL 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0172 0.188 0.1878
Schistosoma mansoni hypothetical protein 0.0494 0.5574 0.5574
Echinococcus multilocularis cysteine protease 0.0879 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0172 0.188 0.1878
Onchocerca volvulus 0.0879 1 1
Onchocerca volvulus Cathepsin L homolog 0.0879 1 1
Leishmania major cathepsin L-like protease 0.0879 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0656 0.0525
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0172 0.188 0.1766
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6315 0.6315
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Onchocerca volvulus 0.0593 0.6708 0.6606
Schistosoma mansoni DNA polymerase eta 0.0023 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.188 0.1878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Echinococcus multilocularis snurportin 1 0.0299 0.3337 0.3337
Brugia malayi CXXC zinc finger family protein 0.0035 0.0299 0.0297
Echinococcus multilocularis cathepsin L 0.0459 0.5172 0.5172
Loa Loa (eye worm) hypothetical protein 0.0119 0.1269 0.1267
Entamoeba histolytica cysteine proteinase 1, putative 0.0459 0.5172 0.5104
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.3415 0.3323
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0049 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Echinococcus multilocularis GPCR, family 2 0.0019 0.012 0.012
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.7931 0.7931
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0172 0.188 0.1766
Trypanosoma cruzi cysteine proteinase, putative 0.0459 0.5172 0.5104
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0295 0.3289 0.3195
Echinococcus granulosus snurportin 1 0.0299 0.3337 0.3337
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Toxoplasma gondii cathepsin B 0.0295 0.3289 0.3195
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0172 0.188 0.1878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0287 0.3193 0.3192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.2251 0.2251
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Loa Loa (eye worm) cysteine protease 0.0879 1 1
Schistosoma mansoni cathepsin s 0.0287 0.3193 0.3193
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0172 0.188 0.1766
Brugia malayi Papain family cysteine protease containing protein 0.0459 0.5172 0.5171
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.012 0.0118
Trypanosoma cruzi cysteine protease, putative 0.0459 0.5172 0.5104
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0169 0.0166
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0459 0.5172 0.5171
Brugia malayi Latrophilin receptor protein 2 0.0019 0.012 0.0118
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0172 0.188 0.1878
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0049 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0172 0.188 0.188
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0138 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.0593 0.6708 0.6662
Echinococcus granulosus cathepsin b 0.0569 0.6436 0.6436
Leishmania major cysteine peptidase A (CPA) 0.0879 1 1
Plasmodium vivax unspecified product 0.0172 0.188 0.1766
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0172 0.188 0.188
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0503 0.037
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0019 0.012 0.0118
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0002 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.016
Leishmania major DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Plasmodium vivax serine-repeat antigen (SERA) 0.0172 0.188 0.1766
Echinococcus granulosus cathepsin l cysteine peptidase 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0569 0.6436 0.6386
Brugia malayi Cathepsin L-like precursor 0.0593 0.6708 0.6707
Plasmodium vivax vivapain-2 0.0879 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0138 0.0053
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0002 0.0002
Loa Loa (eye worm) ctsf protein 0.0879 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0172 0.188 0.1766
Trypanosoma cruzi major cysteine proteinase, putative 0.0172 0.188 0.1766
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Loa Loa (eye worm) hypothetical protein 0.0119 0.1269 0.1267
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Loa Loa (eye worm) hypothetical protein 0.0569 0.6436 0.6435
Leishmania major cathepsin L-like protease 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.2251 0.2251
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0172 0.188 0.188
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0593 0.6708 0.6707
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0172 0.188 0.1766
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Plasmodium vivax serine-repeat antigen (SERA) 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0299 0.3337 0.3337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0049 0.0049
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0295 0.3289 0.3195
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0295 0.3289 0.3231
Plasmodium falciparum serine repeat antigen 5 0.0172 0.188 0.1766
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0172 0.188 0.1878
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0172 0.188 0.188
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Echinococcus multilocularis cysteine protease 0.0879 1 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0169 0.0169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.012 0.0118
Echinococcus granulosus GPCR family 2 0.0019 0.012 0.012
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3415 0.3323
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0172 0.188 0.1766
Echinococcus granulosus cathepsin l1 0.0593 0.6708 0.6708
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0172 0.188 0.1878
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0413 0.041
Giardia lamblia Hypothetical protein 0.0172 0.188 0.5528
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0569 0.6436 0.6436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Onchocerca volvulus 0.0172 0.188 0.1629
Schistosoma mansoni cpg binding protein 0.0037 0.0322 0.0322
Brugia malayi cathepsin L precursor 0.0172 0.188 0.1878
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0379 0.0377
Toxoplasma gondii hypothetical protein 0.0049 0.0468 0.0335
Brugia malayi Papain family cysteine protease containing protein 0.0459 0.5172 0.5171
Loa Loa (eye worm) cathepsin B 0.0295 0.3289 0.3287
Onchocerca volvulus 0.0879 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0879 1 1
Echinococcus multilocularis dna polymerase eta 0.0023 0.0169 0.0169
Onchocerca volvulus 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0162 0.016
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0169 0.0031
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0459 0.5172 0.5104
Plasmodium falciparum cysteine proteinase falcipain 3 0.0879 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0592 0.059
Giardia lamblia Cathepsin L-like protease 0.0172 0.188 0.5528
Brugia malayi Papain family cysteine protease containing protein 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5172 0.513
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0172 0.188 0.1766
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Loa Loa (eye worm) fibroinase 0.0879 1 1
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0002 0.0002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0138 0.0136
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0169 0.0031
Toxoplasma gondii cathepsin CPC1 0.0172 0.188 0.1766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0002 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0169 0.0169
Leishmania major cathepsin L-like protease 0.0879 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0172 0.188 0.1878
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Leishmania major DNA polymerase eta, putative 0.0023 0.0169 0.0031
Trypanosoma cruzi cysteine proteinase, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0295 0.3289 0.3287
Plasmodium vivax vivapain-3 0.0459 0.5172 0.5104
Schistosoma mansoni hypothetical protein 0.0035 0.0303 0.0303
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Echinococcus granulosus cysteine protease 0.0459 0.5172 0.5172
Brugia malayi hypothetical protein 0.0035 0.0303 0.03
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Mycobacterium ulcerans hypothetical protein 0.0161 0.1752 1
Onchocerca volvulus 0.0879 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.3415 0.3359
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0223 0.0223
Trypanosoma cruzi major cysteine proteinase, putative 0.0172 0.188 0.1766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5172 0.513
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Plasmodium vivax importin-beta 2, putative 0.0028 0.0223 0.0086
Entamoeba histolytica cysteine proteinase 2 0.0459 0.5172 0.5104
Echinococcus granulosus cathepsin L cysteine proteinase 0.0879 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3337 0.3336
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Brugia malayi Cathepsin L-like precursor 0.0287 0.3193 0.3192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0169 0.0169
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Brugia malayi hypothetical protein 0.0119 0.1269 0.1267
Brugia malayi Cathepsin L-like precursor 0.0593 0.6708 0.6707
Entamoeba histolytica cysteine protease, putative 0.0879 1 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0172 0.188 0.1766
Echinococcus granulosus microtubule associated protein 2 0.0699 0.7931 0.7931
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0172 0.188 0.1766
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Plasmodium vivax vivapain-2 0.0879 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Echinococcus multilocularis cathepsin L 0.0172 0.188 0.188
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Plasmodium falciparum serine repeat antigen 4 0.0172 0.188 0.1766
Loa Loa (eye worm) hypothetical protein 0.0028 0.0223 0.0221
Leishmania major cathepsin L-like protease 0.0879 1 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0169 0.0169
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0169 0.0169
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.7931 0.7931
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Plasmodium falciparum importin beta, putative 0.0028 0.0223 0.0086
Entamoeba histolytica cysteine proteinase, putative 0.0879 1 1
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0879 1 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0138 0.0138
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Leishmania major importin beta-1 subunit, putative 0.0023 0.0162 0.0024
Schistosoma mansoni cathepsin C 0.0172 0.188 0.188
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0049 0.0049
Toxoplasma gondii preprocathepsin c precursor, putative 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1564 0.1491
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0303 0.0303
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6315 0.6315
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0169 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Plasmodium vivax unspecified product 0.0459 0.5172 0.5104
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5574 0.5574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0172 0.188 0.1878
Plasmodium falciparum serine repeat antigen 9 0.0172 0.188 0.1766
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0413 0.0413
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0879 1 1
Leishmania major cathepsin L-like protease 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0459 0.5172 0.5171
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Plasmodium vivax unspecified product 0.0287 0.3193 0.3098
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Echinococcus granulosus cathepsin L 0.0459 0.5172 0.5172
Plasmodium falciparum serine repeat antigen 8 0.0172 0.188 0.1766
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0172 0.188 0.1766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Echinococcus granulosus cpg binding protein 0.0037 0.0322 0.0322
Onchocerca volvulus 0.0879 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0162 0.0024
Schistosoma mansoni cathepsin B (C01 family) 0.0172 0.188 0.188
Leishmania major cathepsin L-like protease 0.0879 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0459 0.5172 0.5104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0374 0.0372
Onchocerca volvulus 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Onchocerca volvulus Cathepsin L homolog 0.0172 0.188 0.1629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0395 0.0261
Brugia malayi cathepsin L-like cysteine proteinase 0.0172 0.188 0.1878
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0593 0.6708 0.6662
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1564 0.1446
Schistosoma mansoni hypothetical protein 0.0041 0.0374 0.0374
Entamoeba histolytica cysteine proteinase, putative 0.0879 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0287 0.3193 0.3192
Schistosoma mansoni ran 0.0021 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0374 0.0372
Trypanosoma cruzi cruzipain precursor, putative 0.0287 0.3193 0.3098
Brugia malayi cathepsin F-like cysteine proteinase 0.0287 0.3193 0.3192
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Giardia lamblia Cathepsin L-like protease 0.0172 0.188 0.5528
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.046 0.046
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0172 0.188 0.1766
Plasmodium falciparum serine repeat antigen 7 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Brugia malayi cathepsin F-like cysteine proteinase 0.0172 0.188 0.1878
Trypanosoma cruzi cysteine peptidase, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0395 0.0261
Echinococcus multilocularis cpg binding protein 0.0037 0.0322 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6315 0.6315
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Brugia malayi RNA, U transporter 1 0.008 0.0816 0.0814
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0169 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Echinococcus multilocularis cathepsin b 0.0569 0.6436 0.6436
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Echinococcus granulosus cathepsin b 0.0569 0.6436 0.6436
Toxoplasma gondii cathepsin CPC2 0.0172 0.188 0.1766
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0592 0.059
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0379 0.0377
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0172 0.188 0.1766
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0592 0.059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0879 1 1
Plasmodium falciparum serine repeat antigen 6 0.0172 0.188 0.1766
Onchocerca volvulus 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Onchocerca volvulus Cathepsin L homolog 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Giardia lamblia Encystation-specific protease 0.0172 0.188 0.5528
Trichomonas vaginalis ran, putative 0.0021 0.0138 0.0136
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0223 0.0138
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.3193 0.3098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Brugia malayi fibroinase precursor 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0039 0.0345 0.0343
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0223 0.0086
Entamoeba histolytica hypothetical protein 0.0172 0.188 0.1766
Plasmodium falciparum serine repeat antigen 2 0.0172 0.188 0.1766
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Giardia lamblia Hypothetical protein 0.0172 0.188 0.5528
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Onchocerca volvulus Huntingtin homolog 0.0119 0.1269 0.0999
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0395 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Loa Loa (eye worm) hypothetical protein 0.006 0.0592 0.059
Schistosoma mansoni importin beta-1 0.0028 0.0223 0.0223
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0172 0.188 0.1766
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0024 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1564 0.1446
Echinococcus granulosus geminin 0.0205 0.2251 0.2251
Trypanosoma cruzi cruzipain precursor, putative 0.0879 1 1
Giardia lamblia DINP protein human, muc B family 0.0023 0.0169 0.0098
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0002 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0879 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0172 0.188 0.1766
Brugia malayi cathepsin B-like cysteine proteinase 0.0569 0.6436 0.6435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0593 0.6708 0.6707
Leishmania major cathepsin L-like protease 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Echinococcus granulosus cathepsin l1 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0299 0.0297
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0047
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0166
Echinococcus granulosus cathepsin L 0.0172 0.188 0.188
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0395 0.0312
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0879 1 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0172 0.188 0.5528
Schistosoma mansoni cpg binding protein 0.0035 0.0299 0.0299
Leishmania major cathepsin L-like protease 0.0879 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0169 0.0169
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0223 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0295 0.3289 0.3289
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.188 0.1878
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0162 0.0024
Schistosoma mansoni cathepsin S (C01 family) 0.0172 0.188 0.188
Onchocerca volvulus Cathepsin F homolog 0.0879 1 1
Schistosoma mansoni cpg binding protein 0.0037 0.0322 0.0322
Echinococcus multilocularis cathepsin b 0.0569 0.6436 0.6436
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Trypanosoma brucei unspecified product 0.0023 0.0169 0.0084
Echinococcus granulosus cathepsin L cysteine protease 0.0459 0.5172 0.5172
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1752 1
Schistosoma mansoni cathepsin F (C01 family) 0.0593 0.6708 0.6708
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6315 0.6315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Brugia malayi cathepsin L-like precursor 0.0593 0.6708 0.6707
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0223 0.0138
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3415 0.3323
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0169 0.0031
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5574 0.5574
Echinococcus multilocularis cathepsin L cysteine protease 0.0879 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0172 0.188 0.1766
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus granulosus importin subunit beta 1 0.0028 0.0223 0.0223
Brugia malayi Cathepsin L-like cysteine proteinase 0.0593 0.6708 0.6707
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Echinococcus multilocularis cathepsin L cysteine protease 0.0879 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0303 0.0303
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0303 0.0303
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Plasmodium falciparum serine repeat antigen 3 0.0172 0.188 0.1766
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Schistosoma mansoni ran 0.0021 0.0138 0.0138
Echinococcus granulosus dna polymerase eta 0.0023 0.0169 0.0169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Echinococcus multilocularis geminin 0.0205 0.2251 0.2251
Plasmodium falciparum serine repeat antigen 1 0.0172 0.188 0.1766
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.012 0.012
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.8954 0.8954
Schistosoma mansoni cathepsin F (C01 family) 0.0879 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0413 0.041
Plasmodium vivax vivapain-1 0.0459 0.5172 0.5104
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Onchocerca volvulus Huntingtin homolog 0.0119 0.1269 0.0999

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 0.51 uL/min/g Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as intrinsic clearance for enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation per mg of protein by Michaelis-Menten equation ChEMBL. 22293119
Duration (functional) = 48 min Duration of action at which functional detrusor muscle contraction strength was measured using guinea pig model of cystometrogram ChEMBL. 1920357
IC50 (functional) = -5.8 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.3 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.3 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.2 Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.2 Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5 Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -4.9 Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 19734910
Inhibition (ADMET) < 11 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 5 uM CES1 inhibitor clopidogrel-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) < 14 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 30 to 300 uM CES1 inhibitor procainamide-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) = 29 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 10 uM CES1 inhibitor NDGA-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) = 53 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 50 uM CES1 inhibitor clopidogrel-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) = 58 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 5 uM CES2 inhibitor loperamide-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) > 74 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 2 to 20 uM CES2 inhibitor eserine-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) = 80 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 50 uM CES2 inhibitor loperamide-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) > 96 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 10 uM CES inhibitor BNPP-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Inhibition (ADMET) > 97 % Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as 100 uM CES1 inhibitor NDGA-mediated inhibition of enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation at 10 uM for 30 mins by HPLC analysis ChEMBL. 22293119
Kb (binding) = 2.45 nM Antimuscarinic activity against muscarinic M1 receptor in rabbit vas deferens ChEMBL. 9873438
Kb (binding) = 3.44 nM Antimuscarinic activity was evaluated against muscarinic M3 receptor in Guinea-Pig ileum ChEMBL. 9873438
Kb (binding) = 5 nM Antimuscarinic activity was evaluated against muscarinic M2 receptor in Guinea-Pig atria ChEMBL. 9873438
Kb (functional) = 41.6 nM Antimuscarinic effect determined by comparing ability to inhibit carbachol-induced guinea pig detrusor muscle contractions ChEMBL. 1920357
Km (ADMET) = 1.1 mM Activity of human CES2 ChEMBL. 22293119
Km (ADMET) = 22 uM Drug metabolism in human liver microsomes assessed as 2-cyclohexyl-2-phenylglycolic acid formation by Michaelis-Menten equation ChEMBL. 22293119
Km (ADMET) = 62 uM Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation by Michaelis-Menten equation ChEMBL. 22293119
Potency (functional) = 0.14 Effect on in vivo functional detrusor muscle contraction strength using guinea pig model of cystometrogram ChEMBL. 1920357
Potency (functional) 0.7079 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488774] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 84.9214 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Vmax (ADMET) = 32 pmol/min Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as enzyme-mediated 2-cyclohexyl-2-phenylglycolic acid formation per mg of protein by Michaelis-Menten equation ChEMBL. 22293119
Vmax (ADMET) = 0.36 umol/min/mg Activity of human CES2 ChEMBL. 22293119

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19734910

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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