Detailed information for compound 1730921

Basic information

Technical information
  • TDR Targets ID: 1730921
  • Name: 2,4,6-trichlorobenzene-1,3-diol
  • MW: 213.446 | Formula: C6H3Cl3O2
  • H donors: 2 H acceptors: 2 LogP: 3.1 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(Cl)c(c(c1O)Cl)O
  • InChi: 1S/C6H3Cl3O2/c7-2-1-3(8)6(11)4(9)5(2)10/h1,10-11H
  • InChiKey: NHOATJNESSAPCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,4,6-Trichlororesorcinol
  • 26378-73-4
  • 1,3-Benzenediol, 2,4,6-trichloro-
  • NSC36930
  • Resorcinol, 2,4,6-trichloro-
  • ZINC00157940
  • EINECS 247-639-3

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0116 0.0529 0.2068
Echinococcus granulosus tyrosine protein kinase otk 0.0126 0.0625 0.2457
Mycobacterium leprae Possible regulatory protein 0.0085 0.0221 0.5
Schistosoma mansoni tyrosine kinase 0.0152 0.0874 0.3414
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0083 0.021 0.0825
Brugia malayi Furin-like cysteine rich region family protein 0.0181 0.1157 0.1157
Brugia malayi SRC-1 0.0116 0.0529 0.0529
Brugia malayi Immunoglobulin domain containing protein 0.0068 0.0065 0.0065
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0068 0.0065 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0218 0.085
Echinococcus granulosus tyrosine protein kinase Src42A 0.0116 0.0529 0.208
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.013 0.0664 0.0664
Onchocerca volvulus 0.0241 0.1739 0.8855
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Echinococcus multilocularis roundabout 2 0.0126 0.0625 0.2457
Echinococcus multilocularis epidermal growth factor receptor 0.0109 0.0455 0.1789
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0587 0.2295
Schistosoma mansoni hypothetical protein 0.018 0.1148 0.4486
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0065 0.0065
Echinococcus multilocularis tyrosine protein kinase otk 0.0126 0.0625 0.2457
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0089 0.0261 0.1067
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Onchocerca volvulus 0.0118 0.0548 0.2793
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0089 0.0261 0.1067
Loa Loa (eye worm) casein kinase 0.0125 0.0615 0.0615
Loa Loa (eye worm) TK/ROR protein kinase 0.0083 0.021 0.021
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0104 0.0407 0.5072
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Echinococcus granulosus basement membrane specific heparan sulfate 0.0068 0.0065 0.0254
Schistosoma mansoni tyrosine kinase 0.0083 0.0206 0.0806
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0126 0.0625 0.0625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Echinococcus granulosus casein kinase I delta 0.0122 0.0587 0.2309
Loa Loa (eye worm) hypothetical protein 0.0323 0.2532 0.2532
Schistosoma mansoni peroxidasin 0.0068 0.0065 0.0252
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0085 0.0221 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0407 0.5072
Brugia malayi Tyrosine-protein kinase abl-1 0.0133 0.0696 0.0696
Loa Loa (eye worm) hypothetical protein 0.0108 0.0451 0.0451
Loa Loa (eye worm) TK/EGFR protein kinase 0.0181 0.1157 0.1157
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0116 0.0529 0.208
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0104 0.0407 0.16
Echinococcus granulosus tyrosine protein kinase Fyn 0.0116 0.0529 0.208
Loa Loa (eye worm) hypothetical protein 0.0323 0.2532 0.2532
Mycobacterium ulcerans putative regulatory protein 0.0241 0.1739 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0388 0.1523
Loa Loa (eye worm) hypothetical protein 0.0198 0.1319 0.1319
Brugia malayi Immunoglobulin domain containing protein 0.0068 0.0065 0.0065
Schistosoma mansoni vesicular amine transporter 0.0198 0.1319 0.5154
Brugia malayi Protein kinase domain containing protein 0.0075 0.0125 0.0125
Brugia malayi Tyrosine-protein kinase abl-1 0.0138 0.0738 0.0738
Echinococcus granulosus Immunoglobulin subtype 0.0068 0.0065 0.0254
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Echinococcus granulosus contactin 0.0126 0.0625 0.2457
Echinococcus granulosus tyrosine protein kinase Lyn 0.012 0.0568 0.2234
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0407 0.4778
Loa Loa (eye worm) hypothetical protein 0.0198 0.1319 0.1319
Echinococcus granulosus neuroglian 0.0126 0.0625 0.2457
Echinococcus granulosus Immunoglobulin 0.0068 0.0065 0.0254
Schistosoma mansoni hypothetical protein 0.0068 0.0065 0.0252
Schistosoma mansoni hypothetical protein 0.0068 0.0065 0.0252
Entamoeba histolytica casein kinase, putative 0.0122 0.0587 1
Schistosoma mansoni tyrosine kinase 0.0075 0.0125 0.0489
Onchocerca volvulus 0.0085 0.0221 0.1128
Schistosoma mansoni tyrosine kinase 0.0109 0.0455 0.1778
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0116 0.0529 0.208
Brugia malayi hypoxia-induced factor 1 0.1008 0.9179 0.9179
Plasmodium falciparum casein kinase 1 0.0122 0.0587 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0473 0.3986 0.3986
Echinococcus granulosus epidermal growth factor receptor 0.0109 0.0455 0.1789
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0116 0.0529 0.208
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0116 0.0529 0.208
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0065 0.0065
Echinococcus granulosus Immunoglobulin 0.0068 0.0065 0.0254
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0116 0.0529 0.208
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0068 0.0065 0.0252
Onchocerca volvulus 0.0181 0.1154 0.5878
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0122 0.0587 0.0587
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0198 0.1319 0.5186
Schistosoma mansoni cell adhesion molecule 0.0068 0.0065 0.0252
Echinococcus granulosus roundabout 2 0.0126 0.0625 0.2457
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Brugia malayi protein-tyrosine kinase 0.0102 0.0388 0.0388
Entamoeba histolytica casein kinase 1, putative 0.0122 0.0587 1
Schistosoma mansoni septate junction protein 0.0126 0.0625 0.2442
Echinococcus multilocularis casein kinase i 0.0122 0.0587 0.2309
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0654 0.2557
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0116 0.0529 0.208
Onchocerca volvulus Tyrosine kinase homolog 0.0264 0.1964 1
Loa Loa (eye worm) hypothetical protein 0.1092 1 1
Brugia malayi PAS domain containing protein 0.0326 0.256 0.256
Schistosoma mansoni neuroglian 0.0126 0.0625 0.2442
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0089 0.0261 0.1067
Loa Loa (eye worm) TK/ABL protein kinase 0.0257 0.1892 0.1892
Echinococcus granulosus Immunoglobulin 0.0198 0.1319 0.5186
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Brugia malayi basement membrane proteoglycan precursor 0.0068 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Schistosoma mansoni hypothetical protein 0.0068 0.0065 0.0252
Trypanosoma cruzi casein kinase, putative 0.0122 0.0587 1
Echinococcus multilocularis protein kinase shaggy 0.0104 0.0407 0.16
Echinococcus granulosus casein kinase i 0.0122 0.0587 0.2309
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0068 0.0065 0.0252
Schistosoma mansoni single-minded 0.0326 0.256 1
Schistosoma mansoni septate junction protein 0.0068 0.0065 0.0252
Schistosoma mansoni aryl hydrocarbon receptor 0.0326 0.256 1
Schistosoma mansoni netrin receptor unc5 0.0068 0.0065 0.0252
Echinococcus multilocularis netrin receptor unc 5 0.0068 0.0065 0.0254
Echinococcus multilocularis Immunoglobulin 0.0068 0.0065 0.0254
Echinococcus multilocularis hemicentin 1 0.0126 0.0625 0.2457
Echinococcus multilocularis tyrosine protein kinase Srms 0.0102 0.0388 0.1523
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0068 0.0065 0.0254
Echinococcus multilocularis roundabout 2 0.0324 0.2544 1
Echinococcus multilocularis Immunoglobulin 0.0198 0.1319 0.5186
Toxoplasma gondii casein kinase I 0.0122 0.0587 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0076 0.0139 0.0545
Schistosoma mansoni hypothetical protein 0.0068 0.0065 0.0252
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0266 0.1984 0.7797
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0126 0.0625 0.2457
Echinococcus granulosus low density lipoprotein receptor ldl 0.0068 0.0065 0.0254
Trypanosoma cruzi casein kinase, putative 0.0122 0.0587 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0116 0.0529 0.208
Onchocerca volvulus 0.0104 0.0407 0.2073
Echinococcus multilocularis transfer RNA-Lys 0.0241 0.1739 0.6834
Schistosoma mansoni basigin related 0.0068 0.0065 0.0252
Echinococcus granulosus peroxidasin 0.0126 0.0625 0.2457
Echinococcus multilocularis peroxidasin 0.0126 0.0625 0.2457
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Echinococcus granulosus roundabout 2 0.0324 0.2544 1
Echinococcus multilocularis Immunoglobulin 0.0198 0.1319 0.5186
Loa Loa (eye worm) hypothetical protein 0.0198 0.1319 0.1319
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0104 0.0407 0.16
Schistosoma mansoni tyrosine kinase 0.0083 0.0206 0.0806
Echinococcus multilocularis hemicentin 1 0.0126 0.0625 0.2457
Schistosoma mansoni tyrosine kinase 0.0116 0.0529 0.2068
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0122 0.0587 0.0587
Echinococcus granulosus netrin receptor unc 5 0.0068 0.0065 0.0254
Schistosoma mansoni cell adhesion molecule 0.0068 0.0065 0.0252
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0075 0.0125 0.0492
Echinococcus granulosus casein kinase I alpha 0.0122 0.0587 0.2309
Entamoeba histolytica protein kinase, putative 0.0104 0.0407 0.4778
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0104 0.0407 0.0407
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0116 0.0529 0.208
Schistosoma mansoni cell adhesion molecule 0.0126 0.0625 0.2442
Brugia malayi Immunoglobulin domain containing protein 0.0068 0.0065 0.0065
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0084 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0266 0.1984 0.1984
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0122 0.0587 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0085 0.0221 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0407 0.5072
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0116 0.0529 0.208
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Echinococcus multilocularis tyrosine protein kinase Abl 0.0138 0.0738 0.2902
Loa Loa (eye worm) LAD-2 short isoform 0.0068 0.0065 0.0065
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Echinococcus granulosus tyrosine protein kinase HCK 0.0087 0.0242 0.0952
Echinococcus multilocularis aryl hydrocarbon receptor 0.0085 0.0221 0.0871
Echinococcus multilocularis roundabout 2 0.0126 0.0625 0.2457
Echinococcus multilocularis muscleblind protein 1 0.0323 0.2532 0.995
Loa Loa (eye worm) hypoxia-induced factor 1 0.1008 0.9179 0.9179
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0407 0.4778
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0068 0.0065 0.0065
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0102 0.0388 0.1523
Schistosoma mansoni nephrin related 0.0068 0.0065 0.0252
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Echinococcus multilocularis insulin receptor 0.0075 0.0125 0.0492
Echinococcus multilocularis epidermal growth factor receptor 0.0181 0.1157 0.4547
Echinococcus multilocularis casein kinase I alpha 0.0122 0.0587 0.2309
Echinococcus granulosus aryl hydrocarbon receptor 0.0085 0.0221 0.0871
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0068 0.0065 0.0254
Echinococcus granulosus tyrosine protein kinase Fyn 0.0116 0.0529 0.208
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0089 0.0261 0.1067
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0104 0.0407 0.5072
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0085 0.0221 0.0871
Brugia malayi hypothetical protein 0.0198 0.1319 0.1319
Echinococcus multilocularis geminin 0.018 0.1148 0.4514
Echinococcus multilocularis tyrosine protein kinase HCK 0.0087 0.0242 0.0952
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0065 0.0065
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0126 0.0625 0.2457
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Leishmania major protein kinase, putative 0.0089 0.0261 0.1067
Echinococcus granulosus protein kinase shaggy 0.0104 0.0407 0.16
Echinococcus granulosus muscleblind protein 0.0323 0.2532 0.995
Echinococcus granulosus tyrosine kinase 0.0102 0.0388 0.1523
Echinococcus multilocularis lachesin 0.0126 0.0625 0.2457
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0065 0.0065
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0126 0.0625 0.2457
Echinococcus multilocularis muscleblind protein 0.0323 0.2532 0.995
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0076 0.0139 0.0545
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0104 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0324 0.2544 0.2544
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0218 0.085
Echinococcus granulosus epidermal growth factor receptor 0.0181 0.1157 0.4547
Echinococcus granulosus defective proboscis extension response 0.0198 0.1319 0.5186
Schistosoma mansoni titin 0.0126 0.0625 0.2442
Schistosoma mansoni septate junction protein 0.0068 0.0065 0.0252
Brugia malayi bHLH-PAS transcription factor 0.0241 0.1739 0.1739
Echinococcus granulosus insulin receptor 0.0075 0.0125 0.0492
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0126 0.0625 0.2457
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0126 0.0625 0.0625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Schistosoma mansoni tyrosine kinase 0.0242 0.1746 0.6821
Brugia malayi casein kinase I 0.0122 0.0587 0.0587
Echinococcus multilocularis neuroglian 0.0126 0.0625 0.2457
Echinococcus granulosus tyrosine protein kinase Blk 0.0102 0.0388 0.1523
Brugia malayi Immunoglobulin I-set domain containing protein 0.0473 0.3986 0.3986
Schistosoma mansoni tyrosine kinase 0.0075 0.0125 0.0489
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0068 0.0065 0.0254
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0109 0.0455 0.1789
Echinococcus granulosus neuroglian 0.0256 0.188 0.7389
Brugia malayi intracellular kinase 0.0104 0.0407 0.0407
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0068 0.0065 0.0254
Echinococcus multilocularis Immunoglobulin 0.0068 0.0065 0.0254
Echinococcus granulosus single minded 2 0.0241 0.1739 0.6834
Echinococcus multilocularis Immunoglobulin subtype 0.0068 0.0065 0.0254
Echinococcus multilocularis casein kinase I delta 0.0122 0.0587 0.2309
Echinococcus granulosus hemicentin 1 0.0126 0.0625 0.2457
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Schistosoma mansoni cell adhesion molecule 0.0126 0.0625 0.2442
Loa Loa (eye worm) hypothetical protein 0.0198 0.1319 0.1319
Trypanosoma cruzi casein kinase, putative 0.0122 0.0587 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0085 0.0221 0.0871
Trypanosoma brucei casein kinase I, isoform 2 0.0122 0.0587 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0126 0.0625 0.2442
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0068 0.0065 0.0252
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0198 0.1319 0.1319
Schistosoma mansoni tyrosine kinase 0.0083 0.0206 0.0806
Brugia malayi Immunoglobulin I-set domain containing protein 0.0198 0.1319 0.1319
Loa Loa (eye worm) TK protein kinase 0.0087 0.0242 0.0242
Brugia malayi basement membrane proteoglycan 0.0068 0.0065 0.0065
Trypanosoma cruzi casein kinase, putative 0.0122 0.0587 1
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0068 0.0065 0.0254
Trichomonas vaginalis CK1 family protein kinase 0.0122 0.0587 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0104 0.0407 0.159
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0068 0.0065 0.0254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Echinococcus multilocularis casein kinase I delta 0.0122 0.0587 0.2309
Schistosoma mansoni hypothetical protein 0.018 0.1148 0.4486
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0198 0.1319 0.5154
Leishmania major protein kinase, putative 0.0089 0.0261 0.1067
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0068 0.0065 0.0254
Echinococcus granulosus roundabout 2 0.0126 0.0625 0.2457
Schistosoma mansoni hypothetical protein 0.0068 0.0065 0.0252
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0116 0.0529 0.208
Brugia malayi Heparan sulfate 0.0068 0.0065 0.0065
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0068 0.0065 0.0254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0065 0.0065
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0198 0.1319 0.5154
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0126 0.0625 0.2442
Brugia malayi cyclin-dependent kinase 7 homolog 0.0084 0.0218 0.0218
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.021 0.021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0625 0.0625
Brugia malayi Prion-like- 0.0126 0.0625 0.0625
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0083 0.021 0.0825
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0068 0.0065 0.0252
Schistosoma mansoni protein kinase 0.0122 0.0587 0.2295
Schistosoma mansoni tyrosine kinase 0.0181 0.1157 0.4519
Echinococcus multilocularis casein kinase I gamma 0.0129 0.0654 0.2572
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0068 0.0065 0.0065
Loa Loa (eye worm) TK/INSR protein kinase 0.0075 0.0125 0.0125
Echinococcus granulosus casein kinase I gamma 0.0129 0.0654 0.2572
Trichomonas vaginalis CK1 family protein kinase 0.0122 0.0587 1
Echinococcus granulosus twitchin 0.026 0.1919 0.7543
Plasmodium vivax casein kinase 1, putative 0.0122 0.0587 1
Echinococcus granulosus casein kinase I alpha 0.0122 0.0587 0.2309
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0126 0.0625 0.0625
Echinococcus granulosus lachesin 0.0126 0.0625 0.2457
Schistosoma mansoni septate junction protein 0.0126 0.0625 0.2442
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0122 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0198 0.1319 0.1319
Schistosoma mansoni basigin related 0.0068 0.0065 0.0252
Loa Loa (eye worm) hypothetical protein 0.0085 0.0221 0.0221
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0068 0.0065 0.0254
Schistosoma mansoni hypothetical protein 0.0068 0.0065 0.0252
Onchocerca volvulus 0.0122 0.0587 0.2991
Trichomonas vaginalis CK1 family protein kinase 0.0122 0.0587 1
Schistosoma mansoni cell adhesion molecule 0.0126 0.0625 0.2442
Schistosoma mansoni cell adhesion molecule 0.0266 0.1984 0.7749
Schistosoma mansoni tyrosine kinase 0.0109 0.0455 0.1778
Giardia lamblia Kinase, CK1 Casein kinase 0.0122 0.0587 1
Echinococcus multilocularis neuroglian 0.0256 0.188 0.7389
Loa Loa (eye worm) TK protein kinase 0.0083 0.021 0.021
Brugia malayi Protein kinase domain containing protein 0.0129 0.0654 0.0654
Echinococcus granulosus tyrosine protein kinase Src64B 0.0116 0.0529 0.208
Schistosoma mansoni roundabout 0.0126 0.0625 0.2442
Schistosoma mansoni basigin related 0.0068 0.0065 0.0252
Loa Loa (eye worm) protein kinase domain-containing protein 0.0129 0.0654 0.0654
Echinococcus multilocularis casein kinase I alpha 0.0122 0.0587 0.2309
Echinococcus multilocularis casein kinase I alpha 0.0122 0.0587 0.2309
Brugia malayi Fibronectin type III domain containing protein 0.0198 0.1319 0.1319
Brugia malayi casein kinase 1, delta 0.0122 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0126 0.0625 0.0625
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0118 0.0548 0.8933
Echinococcus granulosus tyrosine protein kinase ABL1 0.0257 0.1892 0.7435
Echinococcus multilocularis cyclin dependent kinase 7 0.0084 0.0218 0.0856
Trypanosoma cruzi casein kinase, putative 0.0122 0.0587 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0102 0.0388 0.1523
Echinococcus granulosus tyrosine protein kinase Fyn 0.0116 0.0529 0.208
Echinococcus granulosus cyclin dependent kinase 7 0.0084 0.0218 0.0856
Brugia malayi Peroxidasin 0.0126 0.0625 0.0625
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0257 0.1892 0.7435
Leishmania major casein kinase, putative 0.0122 0.0587 1
Loa Loa (eye worm) SRC-1 0.0116 0.0529 0.0529
Schistosoma mansoni netrin receptor unc5 0.0068 0.0065 0.0252
Echinococcus granulosus casein kinase I delta 0.0122 0.0587 0.2309
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0075 0.0125 0.0492
Loa Loa (eye worm) TK protein kinase 0.0102 0.0388 0.0388
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0126 0.0625 0.2457
Brugia malayi Muscleblind-like protein 0.0323 0.2532 0.2532
Schistosoma mansoni nephrin 0.0256 0.188 0.7344
Schistosoma mansoni nephrin 0.0126 0.0625 0.2442
Echinococcus granulosus casein kinase I alpha 0.0122 0.0587 0.2309
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0116 0.0529 0.208
Brugia malayi hypothetical protein 0.0068 0.0065 0.0065
Echinococcus granulosus geminin 0.018 0.1148 0.4514
Loa Loa (eye worm) hypothetical protein 0.0324 0.2544 0.2544
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0126 0.0625 0.2457
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0126 0.0625 0.3184

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 73 % Inactivation of tyrosinase (unknown origin) assessed as decay half-life using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry ChEMBL. 23352755
Activity (binding) = 86 % Inactivation of tyrosinase (unknown origin) assessed as total oxygen uptake using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry ChEMBL. 23352755
Activity (binding) = 105 % Inactivation of tyrosinase (unknown origin) assessed as initial rate of oxygen utilization at absorbance 400 nm using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry ChEMBL. 23352755
Activity (binding) = 110 % Inactivation of tyrosinase (unknown origin) assessed as initial rate of oxygen utilization using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry ChEMBL. 23352755

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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