TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 370.829 | Formula: C20H19ClN2O3
H donors: 0 H acceptors: 1 LogP: 3.4 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C1=NN(C(C1)c1ccc2c(c1)OCCCO2)C(=O)C
InChi: 1S/C20H19ClN2O3/c1-13(24)23-18(12-17(22-23)14-3-6-16(21)7-4-14)15-5-8-19-20(11-15)26-10-2-9-25-19/h3-8,11,18H,2,9-10,12H2,1H3
InChiKey: DQQYGMAXFRKJKB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cathepsin b	0.0142	0.3354	0.3354
Echinococcus multilocularis	G protein coupled receptor 139	0.0036	0.0709	0.0709
Onchocerca volvulus		0.0036	0.0709	0.2272
Echinococcus granulosus	serotonin receptor	0.0036	0.0709	0.0709
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0036	0.0709	0.2272
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.1006	0.2733
Onchocerca volvulus		0.0036	0.0709	0.2272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0074	0.0074
Schistosoma mansoni	cathepsin S (C01 family)	0.0012	0.0122	0.0122
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0122	0.0144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.1008	0.1008
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.0122	0.0122
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0012	0.0122	0.0139
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Schistosoma mansoni	amine GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0709	0.0709
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.1008	0.1703
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0709	0.0709
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0036	0.0709	0.118
Brugia malayi	cathepsin L precursor	0.0012	0.0122	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0052	0.1122	0.3093
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0074	0.0059
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0724	0.1201
Brugia malayi	cathepsin B-like cysteine proteinase	0.0142	0.3354	0.5847
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0074	0.0059
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0985	0.0985
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Echinococcus granulosus	cathepsin L	0.0027	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1008	0.1703
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Onchocerca volvulus	Cathepsin L homolog	0.0048	0.1006	0.3331
Schistosoma mansoni	survival motor neuron protein	0.0048	0.1023	0.1023
Schistosoma mansoni	hypothetical protein	0.0171	0.4063	0.4063
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0014	0.0181	0.0247
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0027	0.048	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0181	0.0242
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	g-protein coupled receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.0122	0.0122
Loa Loa (eye worm)	fibroinase	0.0048	0.1006	0.1699
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.048	0.3583
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0048	0.1006	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.3354	0.3354
Echinococcus multilocularis	cathepsin L	0.0027	0.048	0.048
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	hypothetical protein	0.0048	0.1008	0.1008
Brugia malayi	Cathepsin L-like precursor	0.0048	0.1006	0.1703
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	geminin	0.0171	0.4063	0.4063
Plasmodium vivax	unspecified product	0.0027	0.048	0.4054
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0036	0.0709	0.0709
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.1333	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus granulosus	G protein coupled receptor 139	0.0036	0.0709	0.0709
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.048	0.1108
Loa Loa (eye worm)	cysteine protease	0.0048	0.1006	0.1699
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	ctsf protein	0.0048	0.1006	0.1699
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0985	0.0985
Echinococcus granulosus	allatostatin A receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0052	0.1122	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.048	0.048
Giardia lamblia	Cathepsin B precursor	0.0052	0.1122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus granulosus	neuropeptide receptor A26	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0151	0.357	0.6227
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0074	0.0059
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.1006	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0709	0.0709
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0048	0.1006	0.1006
Onchocerca volvulus		0.0036	0.0709	0.2272
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0724	0.1201
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0074	0.0054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0048	0.1006	0.1006
Echinococcus granulosus	g-protein coupled receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0724	0.0724
Onchocerca volvulus		0.0048	0.1006	0.3331
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0033	0.0647	0.1625
Schistosoma mansoni	coup transcription factor	0.001	0.0074	0.0074
Onchocerca volvulus	Cathepsin L homolog	0.0048	0.1006	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.1122	0.1122
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0014	0.0181	0.0242
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0724	0.1201
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0709	0.1176
Echinococcus granulosus	cathepsin l1	0.0033	0.0647	0.0647
Onchocerca volvulus		0.0036	0.0724	0.2323
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0074	0.0074
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	cathepsin l1	0.0048	0.1006	0.1006
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0074	0.0074
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0074	0.0074
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.1008	0.1008
Echinococcus granulosus	7tm_1 domain containing protein	0.0036	0.0709	0.0709
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Brugia malayi	putative neuropeptide receptor	0.0036	0.0709	0.118
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.1006	0.2733
Onchocerca volvulus		0.0036	0.0709	0.2272
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0139
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0709	0.0709
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0074	0.0074
Brugia malayi	beta-lactamase family protein	0.0036	0.0724	0.1205
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0537	0.0876
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0985	0.1662
Brugia malayi	Dopamine receptor	0.0036	0.0709	0.118
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0036	0.0709	0.0709
Plasmodium vivax	vivapain-2	0.0048	0.1006	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0027	0.048	0.4054
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0074	0.0074
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0052	0.1122	0.6529
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.048	0.4054
Onchocerca volvulus		0.0036	0.0709	0.2272
Onchocerca volvulus		0.0036	0.0709	0.2272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.1333	0.1333
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.048	0.4054
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0036	0.0709	0.1176
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Onchocerca volvulus		0.0036	0.0709	0.2272
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2871	0.4993
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0036	0.0709	0.118
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0012	0.0122	0.0122
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Brugia malayi	G protein-coupled receptor	0.0036	0.0709	0.118
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0036	0.0709	0.118
Schistosoma mansoni	hypothetical protein	0.0048	0.1008	0.1008
Echinococcus multilocularis	allatostatin A receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0036	0.0709	0.0709
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0709	0.0709
Echinococcus granulosus	GPCR family 2	0.0048	0.1008	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.1333	0.1256
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0012	0.0122	0.0144
Brugia malayi	ecdysteroid receptor	0.001	0.0074	0.0059
Giardia lamblia	Cathepsin B precursor	0.0052	0.1122	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0036	0.0709	0.0709
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.1333	1
Brugia malayi	Cathepsin L-like precursor	0.0048	0.1006	0.1703
Echinococcus granulosus	orexin receptor type 2	0.0036	0.0709	0.0709
Echinococcus multilocularis	cysteine protease	0.0048	0.1006	0.1006
Brugia malayi	beta-lactamase	0.0036	0.0724	0.1205
Onchocerca volvulus		0.0036	0.0709	0.2272
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	hypothetical protein	0.0036	0.0709	0.0709
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.1008	0.1008
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0647	0.5255
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Onchocerca volvulus		0.0036	0.0709	0.2272
Brugia malayi	fibroinase precursor	0.0012	0.0122	0.0144
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0074	0.0074
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0027	0.048	0.4054
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0036	0.0709	0.0709
Entamoeba histolytica	cysteine proteinase 2	0.0027	0.048	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Onchocerca volvulus		0.0036	0.0709	0.2272
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0036	0.0709	0.0709
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0036	0.0709	0.0709
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0074	0.0059
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0237	0.5706	1
Brugia malayi	Dopamine receptor protein 1	0.0036	0.0709	0.118
Schistosoma mansoni	hypothetical protein	0.0048	0.1023	0.1023
Schistosoma mansoni	growth hormone secretagogue receptor	0.0036	0.0709	0.0709
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0074	0.0074
Toxoplasma gondii	cathepsin B	0.0052	0.1122	0.8252
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0142	0.3354	0.3354
Echinococcus multilocularis	cysteine protease	0.0048	0.1006	0.1006
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0036	0.0709	0.0709
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0724	0.1861
Brugia malayi	AKH receptor	0.0036	0.0709	0.118
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0709	0.0709
Onchocerca volvulus		0.0036	0.0709	0.2272
Schistosoma mansoni	amine GPCR	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0709	0.0709
Onchocerca volvulus		0.0048	0.1023	0.3392
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0012	0.0122	0.0144
Brugia malayi	ORL1-like opioid receptor	0.0036	0.0709	0.118
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0036	0.0709	0.2272
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Brugia malayi	Cathepsin L-like precursor	0.0048	0.1006	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0647	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0036	0.0709	0.118
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0724	0.3792
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0537	0.0871
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0012	0.0122	0.0122
Schistosoma mansoni	myosin xvIII	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0048	0.1006	0.1006
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.357	0.6227
Schistosoma mansoni	opsin-like receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus granulosus	neuropeptide s receptor	0.0036	0.0709	0.0709
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.1006	0.1703
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0724	0.0724
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.048	0.1108
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0036	0.0709	0.1176
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0074	0.0074
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0048	0.1006	0.1006
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0724	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0709	0.0709
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0074	0.0059
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	cathepsin C	0.0012	0.0122	0.0122
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1338	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Onchocerca volvulus		0.0033	0.0647	0.2051
Echinococcus multilocularis	GPCR, family 2	0.0048	0.1008	0.1008
Echinococcus granulosus	somatostatin receptor	0.0036	0.0709	0.0709
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0181	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Echinococcus granulosus	hypothetical protein	0.0036	0.0709	0.0709
Echinococcus multilocularis	cathepsin L cysteine protease	0.0048	0.1006	0.1006
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.357	0.6229
Loa Loa (eye worm)	hypothetical protein	0.0142	0.3354	0.5845
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0724	0.0724
Loa Loa (eye worm)	TYRA-2 protein	0.0036	0.0709	0.1176
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.5706	0.5706
Trypanosoma cruzi	cysteine peptidase, putative	0.0014	0.0181	0.018
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0012	0.0122	0.0139
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0709	0.0709
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0036	0.0709	0.0709
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.1023	0.1733
Echinococcus granulosus	cathepsin b	0.0142	0.3354	0.3354
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus granulosus	sex peptide receptor	0.0036	0.0709	0.0709
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1333	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Onchocerca volvulus		0.0048	0.1006	0.3331
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0036	0.0709	0.1176
Brugia malayi	nuclear receptor NHR-88	0.001	0.0074	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Giardia lamblia	Cathepsin B precursor	0.0052	0.1122	1
Brugia malayi	steroid hormone receptor	0.001	0.0074	0.0059
Schistosoma mansoni	hypothetical protein	0.0036	0.0709	0.0709
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0033	0.0647	0.1071
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0074	0.0059
Echinococcus granulosus	fmrfamide receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0036	0.0709	0.0709
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2871	0.4993
Schistosoma mansoni	hypothetical protein	0.0048	0.1008	0.1008
Entamoeba histolytica	cysteine protease, putative	0.0048	0.1006	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0036	0.0709	0.0709
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0709	0.0709
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0074	0.0074
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Brugia malayi	hypothetical protein	0.0123	0.2871	0.4995
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0036	0.0709	0.0709
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0724	0.6016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Schistosoma mansoni	hypothetical protein	0.0103	0.2384	0.2384
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0709	0.0709
Onchocerca volvulus		0.0048	0.1006	0.3331
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0724	0.6016
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0074	0.0074
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0036	0.0709	0.0709
Plasmodium vivax	vivapain-1	0.0027	0.048	0.4054
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.1008	0.1008
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0709	0.0709
Brugia malayi	G protein-coupled receptor F59B2.13	0.0036	0.0709	0.118
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0052	0.1122	1
Schistosoma mansoni	opsin-like receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0074	0.0074
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0012	0.0122	0.0144
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0709	0.0709
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.1008	0.1708
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0074	0.0074
Onchocerca volvulus	Huntingtin homolog	0.0123	0.2871	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0012	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	histamine h1 receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.5706	0.5706
Schistosoma mansoni	amine GPCR	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0074	0.0074
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Schistosoma mansoni	amine GPCR	0.0036	0.0709	0.0709
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.1006	0.2733
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Onchocerca volvulus		0.0036	0.0709	0.2272
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1006	0.1699
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0074	0.0059
Brugia malayi	putative neuropeptide receptor NPR1	0.0036	0.0709	0.118
Onchocerca volvulus		0.0036	0.0709	0.2272
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.5579	1
Onchocerca volvulus		0.0048	0.1006	0.3331
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0074	0.0059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0724	0.1201
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0074	0.0059
Echinococcus granulosus	geminin	0.0171	0.4063	0.4063
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0181	0.0242
Schistosoma mansoni	neuropeptide f receptor 76f	0.0036	0.0709	0.0709
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0036	0.0709	0.1176
Onchocerca volvulus		0.0036	0.0724	0.2323
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0985	0.0985
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0074	0.0054
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0724	0.5
Echinococcus multilocularis	serotonin receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0709	0.1176
Echinococcus multilocularis	sex peptide receptor	0.0036	0.0709	0.0709
Echinococcus granulosus	cpg binding protein	0.003	0.0578	0.0578
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.048	0.0776
Onchocerca volvulus	Cathepsin L homolog	0.0012	0.0122	0.0173
Onchocerca volvulus		0.0048	0.1006	0.3331
Echinococcus granulosus	cathepsin L cysteine protease	0.0027	0.048	0.048
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0709	0.0709
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.1333	0.1333
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0647	0.0647
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Toxoplasma gondii	ABC1 family protein	0.0036	0.0724	0.4965
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.0122	0.0122
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0985	0.0985
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0709	0.0709
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0142	0.3354	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0139
Brugia malayi	neuropeptide F receptor	0.0036	0.0709	0.118
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0724	0.1201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0709	0.0709
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0985	0.1666
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Schistosoma mansoni	hypothetical protein	0.0036	0.0709	0.0709
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0709	0.0709
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.048	0.3583
Schistosoma mansoni	cathepsin F (C01 family)	0.0048	0.1006	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0074	0.0074
Echinococcus granulosus	cathepsin b	0.0142	0.3354	0.3354
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Onchocerca volvulus		0.0048	0.1006	0.3331
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0074	0.0054
Onchocerca volvulus		0.0036	0.0724	0.2323
Echinococcus multilocularis	cpg binding protein	0.003	0.0578	0.0578
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0709	0.0709
Onchocerca volvulus	Huntingtin homolog	0.0123	0.2871	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0985	0.0985
Brugia malayi	G-protein coupled receptor	0.0036	0.0709	0.118
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0709	0.0709
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0074	0.0074
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0012	0.0122	0.0139
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.048	0.048
Brugia malayi	Serotonin receptor	0.0036	0.0709	0.118
Echinococcus multilocularis	dnaJ subfamily B	0.041	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	hypothetical protein	0.041	1	1
Onchocerca volvulus		0.0048	0.1006	0.3331
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0709	0.0709
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0724	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0036	0.0709	0.0709
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.1008	0.1708
Onchocerca volvulus		0.0029	0.0537	0.1656
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	somatostatin receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	cathepsin L	0.0012	0.0122	0.0122
Onchocerca volvulus		0.0036	0.0709	0.2272
Trichomonas vaginalis	esterase, putative	0.0036	0.0724	0.6016
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0074	0.0074
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0647	0.1071
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.357	0.6229
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2384	0.4133
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Brugia malayi	beta-lactamase family protein	0.0036	0.0724	0.1205
Onchocerca volvulus	Cathepsin F homolog	0.0048	0.1006	0.3331
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0724	0.6807
Brugia malayi	larval opioid receptor	0.0036	0.0709	0.118
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Plasmodium vivax	vivapain-2	0.0048	0.1006	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.048	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.0122	0.0122
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0724	0.6016
Brugia malayi	cathepsin L-like cysteine proteinase	0.0012	0.0122	0.0144
Schistosoma mansoni	hypothetical protein	0.0036	0.0709	0.0709
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0709	0.0709
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0139
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0647	0.5946
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Schistosoma mansoni	hypothetical protein	0.0048	0.1008	0.1008
Schistosoma mansoni	cathepsin F (C01 family)	0.0048	0.1006	0.1006
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.1333	0.1333
Toxoplasma gondii	cathepsin CPL	0.0048	0.1006	0.7293
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0048	0.1006	0.1699
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1333	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Brugia malayi	cathepsin F-like cysteine proteinase	0.0012	0.0122	0.0144
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0074	0.0059
Brugia malayi	cathepsin L-like precursor	0.0033	0.0647	0.1071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Echinococcus multilocularis	neuropeptide s receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	cathepsin B	0.0052	0.1122	0.1904
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0709	0.1176
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	dro:myosuppressin receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0709	0.0709
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0709	0.0709
Brugia malayi	G-protein coupled receptor	0.0036	0.0709	0.118
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0074	0.0074
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0709	0.0709
Brugia malayi	latrophilin 2 splice variant baaae	0.0103	0.2384	0.4136
Echinococcus granulosus	cysteine protease	0.0027	0.048	0.048
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0054
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0074	0.0074
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0709	0.0709
Schistosoma mansoni	cathepsin s	0.0014	0.0181	0.0181
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0139
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0709	0.0709
Brugia malayi	nuclear hormone receptor	0.001	0.0074	0.0059
Brugia malayi	Cathepsin L-like precursor	0.0048	0.1006	0.1703
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0724	0.1205
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.1333	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0074	0.0059
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.1006	0.8838
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0036	0.0709	0.118
Entamoeba histolytica	cysteine proteinase, putative	0.0048	0.1006	1
Schistosoma mansoni	hypothetical protein	0.0171	0.4063	0.4063
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Leishmania major	cysteine peptidase A (CPA)	0.0048	0.1006	0.4624
Echinococcus multilocularis	serotonin receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0724	0.6016
Schistosoma mansoni	opsin-like receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.3354	0.3354
Trypanosoma cruzi	cysteine peptidase, putative	0.0048	0.1006	0.2733
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0036	0.0709	0.0709
Plasmodium vivax	unspecified product	0.0014	0.0181	0.066
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0724	0.0724
Schistosoma mansoni	cathepsin B (C01 family)	0.0012	0.0122	0.0122
Brugia malayi	Cathepsin L-like precursor	0.0048	0.1006	0.1703
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0036	0.0709	0.118
Brugia malayi	GnHR receptor homolog	0.0036	0.0709	0.118
Onchocerca volvulus		0.0012	0.0122	0.0173
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0074	0.0054
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Schistosoma mansoni	adenoreceptor	0.0036	0.0709	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0181	0.0242
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0985	0.0985
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0048	0.1006	1
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0709	0.0709
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0709	0.0709
Loa Loa (eye worm)	melatonin receptor type 1A	0.0036	0.0709	0.1176
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Schistosoma mansoni	cpg binding protein	0.0029	0.0537	0.0537
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Entamoeba histolytica	cysteine protease, putative	0.0027	0.048	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0036	0.0709	0.0709
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	7TM GPCR rhodopsin	0.0036	0.0709	0.0709
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0048	0.1006	0.1006
Onchocerca volvulus		0.0036	0.0709	0.2272
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0709	0.0709
Brugia malayi	Cathepsin L-like precursor	0.0048	0.1006	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0724	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0647	0.1066
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0709	0.0709
Trypanosoma cruzi	cruzipain precursor, putative	0.0014	0.0181	0.018
Trypanosoma cruzi	cysteine protease, putative	0.0027	0.048	0.1108
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1176	0.8703
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.048	0.4054
Leishmania major	cathepsin L-like protease	0.0048	0.1006	0.4624
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0048	0.1006	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0724	0.1201
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.048	0.0776
Brugia malayi	follicle stimulating hormone receptor	0.0036	0.0709	0.118
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0048	0.1006	0.8838
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0074	0.0074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0074	0.0054
Brugia malayi	hypothetical protein	0.0036	0.0709	0.118
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0074	0.0074
Brugia malayi	Dopamine receptor protein 2	0.0036	0.0709	0.118
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0122	0.0144
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0074	0.0059
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0074	0.0074
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0724	0.6016
Trypanosoma cruzi	cruzipain precursor, putative	0.0048	0.1006	0.2733
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Onchocerca volvulus		0.0036	0.0709	0.2272
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	dro:myosuppressin receptor	0.0036	0.0709	0.0709
Brugia malayi	hypothetical protein	0.0237	0.5706	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0048	0.1006	0.1699
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0709	0.0709
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1333	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.3354	0.3354
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0139
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0036	0.0709	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus multilocularis	cathepsin b	0.0142	0.3354	0.3354
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0012	0.0122	0.0122
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0074	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0724	0.1201
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0074	0.0059
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0122	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0048	0.1006	0.8189
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0074	0.0074
Brugia malayi	cathepsin F-like cysteine proteinase	0.0014	0.0181	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0647	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0074	0.0054
Echinococcus granulosus	cathepsin L	0.0012	0.0122	0.0122
Brugia malayi	neuropeptide F receptor	0.0036	0.0709	0.118
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0985	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Plasmodium vivax	vivapain-3	0.0027	0.048	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0647	0.1066
Brugia malayi	Melatonin receptor type 1A	0.0036	0.0709	0.118
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0074	0.0059
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0709	0.1176
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0074	0.0054
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0709	0.0709
Onchocerca volvulus		0.0036	0.0709	0.2272
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0074	0.0059
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0036	0.0709	0.0709
Brugia malayi	Serotonin receptor	0.0036	0.0709	0.118
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0074	0.0054
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0709	0.1176
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.0122	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.1006	0.8838
Schistosoma mansoni	amine GPCR	0.0036	0.0709	0.0709
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0074	0.0074
Brugia malayi	sulfakinin receptor protein	0.0036	0.0709	0.118
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0709	0.0709
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.048	0.1108
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0036	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0647	0.5255
Brugia malayi	RE15519p	0.0036	0.0709	0.118
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0709	0.0709

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.083	Inhibition of telomerase in human SGC7901 cells by TRAP assay	ChEMBL.	23312949
IC50 (binding)	= 82.6 uM	Inhibition of telomerase in human SGC7901 cells by TRAP assay	ChEMBL.	23312949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333202

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1732703