TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 510.705 | Formula: C32H46O5
H donors: 0 H acceptors: 3 LogP: 5.43 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: CC(=O)O[C@H]([C@H]1OC1(C)C)C[C@H](C1=C2C=CC3[C@]([C@]2(CC1=O)C)(C)CCC1[C@]3(C)CCC(=O)C1(C)C)C
InChi: 1S/C32H46O5/c1-18(16-22(36-19(2)33)27-29(5,6)37-27)26-20-10-11-24-30(7)14-13-25(35)28(3,4)23(30)12-15-31(24,8)32(20,9)17-21(26)34/h10-11,18,22-24,27H,12-17H2,1-9H3/t18-,22+,23?,24?,27-,30+,31+,32+/m1/s1
InChiKey: ARRUGSBFWQZLTR-BGTPOSJASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	brg-1 associated factor	0.0912	0.6433	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0017	0.0011	0.0036
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0017	0.0011	0.0011
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Toxoplasma gondii	ran binding protein	0.0324	0.2219	0.3447
Schistosoma mansoni	voltage-gated potassium channel	0.0083	0.0485	0.0754
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0071	0.011
Loa Loa (eye worm)	hypothetical protein	0.0324	0.2219	0.345
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0071	0.011
Plasmodium vivax	DNA repair protein RAD5, putative	0.0017	0.0011	0.0012
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0324	0.2219	0.345
Toxoplasma gondii	helicase, putative	0.0017	0.0011	0.0012
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0022	0.005	0.005
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Trichomonas vaginalis	hypothetical protein	0.0017	0.0011	0.0017
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0324	0.2219	0.2219
Echinococcus multilocularis		0.0017	0.0011	0.0011
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0003	0.0003
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Echinococcus multilocularis	SWI:SNF matrix associated	0.0912	0.6433	0.6433
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0912	0.6433	1
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0017	0.0011	0.0017
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0017	0.0011	0.0011
Leishmania major	hypothetical protein, conserved	0.0324	0.2219	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0144	0.0225
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0144	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Leishmania major	hypothetical protein	0.0017	0.0011	0.0036
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0017	0.0011	0.0017
Schistosoma mansoni	ring finger protein 151	0.0017	0.0011	0.0017
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0144	0.0225
Schistosoma mansoni	RNA binding protein	0.0324	0.2219	0.345
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Brugia malayi	Zinc finger protein 183 homolog	0.0017	0.0011	0.0017
Echinococcus granulosus	microtubule associated protein 2	0.0673	0.4718	0.4718
Loa Loa (eye worm)	RING finger protein 20	0.0017	0.0011	0.0017
Schistosoma mansoni	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0071	0.0306
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Entamoeba histolytica	SPRY domain protein	0.0017	0.0011	0.5
Onchocerca volvulus		0.0035	0.0144	0.0208
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Brugia malayi	Neuralized family protein	0.0017	0.0011	0.0017
Echinococcus granulosus	RING finger protein 185	0.0017	0.0011	0.0011
Schistosoma mansoni	rnf5	0.0017	0.0011	0.0017
Onchocerca volvulus		0.0324	0.2219	0.3438
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0363	0.0565
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Echinococcus granulosus	voltage gated potassium channel	0.0022	0.005	0.005
Schistosoma mansoni	TRABID protein (C64 family)	0.0324	0.2219	0.345
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Chlamydia trachomatis	DNA topoisomerase I	0.0912	0.6433	0.5
Brugia malayi	RING finger protein 20	0.0017	0.0011	0.0017
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0144	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Echinococcus multilocularis	tumor protein p63	0.141	1	1
Trichomonas vaginalis	ankyrin, putative	0.0017	0.0011	0.0017
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0144	0.022
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0144	0.0225
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0728	0.1131
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0144	0.0943
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0144	0.0943
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0144	1
Echinococcus multilocularis	ring finger protein 170	0.0017	0.0011	0.0011
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0144	1
Brugia malayi	hypothetical protein	0.0017	0.0011	0.0017
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0144	0.0225
Schistosoma mansoni	peter pan-related	0.0017	0.0011	0.0017
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Leishmania major	hypothetical protein, conserved	0.0324	0.2219	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0324	0.2219	0.3447
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0025	0.0071	0.0306
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0017	0.0011	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0144	0.5
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0017	0.0011	0.0011
Leishmania major	hypothetical protein, conserved	0.0035	0.0144	0.0638
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0017	0.0011	0.0036
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0324	0.2219	0.3447
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0324	0.2219	0.3438
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0071	0.0306
Echinococcus granulosus	Zinc finger RanBP2 type	0.0324	0.2219	0.2219
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0324	0.2219	1
Toxoplasma gondii	hypothetical protein	0.0017	0.0011	0.0012
Giardia lamblia	Ser/Thr protein kinase	0.0017	0.0011	1
Entamoeba histolytica	hypothetical protein	0.0017	0.0011	0.5
Toxoplasma gondii	RING zinc finger protein	0.0017	0.0011	0.0012
Onchocerca volvulus		0.0912	0.6433	1
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Echinococcus granulosus	ring finger protein 170	0.0017	0.0011	0.0011
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0324	0.2219	0.2219
Onchocerca volvulus		0.0231	0.1549	0.2395
Loa Loa (eye worm)	RiNg Finger protein family member	0.0017	0.0011	0.0017
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0101	0.0153
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0017	0.0011	0.0017
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0017	0.0011	0.0036
Leishmania major	hypothetical protein, unknown function	0.0017	0.0011	0.0036
Echinococcus granulosus	SWI:SNF matrix associated	0.0912	0.6433	0.6433
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0022	0.005	0.0077
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0011	0.0036
Plasmodium vivax	hypothetical protein, conserved	0.0912	0.6433	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0071	0.0399	0.0621
Toxoplasma gondii	hypothetical protein	0.0017	0.0011	0.0012
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0071	0.011
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0011	0.0036
Plasmodium falciparum	trophozoite exported protein 1	0.0017	0.0011	0.0012
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0017	0.0011	0.0017
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0912	0.6433	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0912	0.6433	1
Chlamydia trachomatis	SWIB complex protein	0.0912	0.6433	0.5
Toxoplasma gondii	hypothetical protein	0.0017	0.0011	0.0012
Schistosoma mansoni	hypothetical protein	0.0912	0.6433	1
Leishmania major	hypothetical protein, conserved	0.0324	0.2219	1
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0144	0.0225
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0101	0.0158
Brugia malayi	YY1-associated factor 2	0.0324	0.2219	0.345
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0144	0.0225
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0017	0.0011	0.0017
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0101	0.0101
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Onchocerca volvulus		0.0029	0.0101	0.0141
Brugia malayi	brahma associated protein 60 kDa	0.0912	0.6433	1
Onchocerca volvulus		0.0324	0.2219	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0022	0.005	0.0077
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0101	0.0158
Trypanosoma cruzi	hypothetical protein	0.0017	0.0011	0.0036
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0017	0.0011	0.0017
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0017	0.0011	0.0017
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Brugia malayi	beta-lactamase	0.0035	0.0144	0.0225
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.005	0.0077
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0071	0.011
Brugia malayi	brahma associated protein 60 kDa	0.0912	0.6433	1
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0324	0.2219	0.345
Loa Loa (eye worm)	CYP4Cod1	0.0025	0.0071	0.011
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0022	0.005	0.005
Echinococcus granulosus	zinc finger protein Ran binding	0.0324	0.2219	0.2219
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0076	0.0435	0.0676
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0324	0.2219	0.2219
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0144	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0071	0.0399	0.0621
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0324	0.2219	1
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0011	0.0036
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0324	0.2219	1
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0017	0.0011	0.0011
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0003	0.0005
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0144	0.0943
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Entamoeba histolytica	hypothetical protein	0.0017	0.0011	0.5
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0324	0.2219	0.345
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.005	0.0077
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0011	0.0017
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0144	0.0943
Trypanosoma cruzi	hypothetical protein	0.0017	0.0011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Schistosoma mansoni	zinc finger protein	0.0017	0.0011	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0324	0.2219	1
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Onchocerca volvulus		0.0035	0.0144	0.0208
Onchocerca volvulus		0.0035	0.0144	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0011	0.0036
Plasmodium falciparum	zinc finger protein, putative	0.0017	0.0011	0.0012
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0324	0.2219	1
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trichomonas vaginalis	ankyrin, putative	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Brugia malayi	B-box zinc finger family protein	0.0017	0.0011	0.0017
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Schistosoma mansoni	fusion	0.0324	0.2219	0.345
Trichomonas vaginalis	ankyrin, putative	0.0017	0.0011	0.0017
Echinococcus multilocularis	SWI:SNF matrix associated	0.0912	0.6433	0.6433
Echinococcus multilocularis	voltage gated potassium channel	0.0022	0.005	0.005
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0003	0.0003
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0076	0.0435	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0324	0.2219	0.345
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0017	0.0011	0.0012
Echinococcus multilocularis	SWI:SNF matrix associated	0.0912	0.6433	0.6433
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0912	0.6433	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0003	0.0003
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0017	0.0011	0.0011
Echinococcus multilocularis	ring and YY1 binding protein	0.0324	0.2219	0.2219
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0324	0.2219	0.345
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0144	0.0225
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Brugia malayi	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma brucei	DNA repair protein, putative	0.0017	0.0011	0.0036
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0144	1
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0144	0.0943
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0017	0.0011	0.0012
Trypanosoma cruzi	hypothetical protein, conserved	0.0324	0.2219	1
Schistosoma mansoni	hypothetical protein	0.0912	0.6433	1
Loa Loa (eye worm)	brahma associated protein	0.0912	0.6433	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0324	0.2219	1
Trypanosoma brucei	hypothetical protein, conserved	0.0324	0.2219	1
Trypanosoma brucei	predicted zinc finger protein	0.0017	0.0011	0.0036
Schistosoma mansoni	hypothetical protein	0.0324	0.2219	0.345
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0003	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Brugia malayi	Zinc finger, C2H2 type family protein	0.0017	0.0011	0.0017
Schistosoma mansoni	hypothetical protein	0.0912	0.6433	1
Trichomonas vaginalis	ion channel nompc, putative	0.0017	0.0011	0.0017
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0017	0.0011	0.0011
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0017	0.0011	0.0036
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1372	0.2133
Toxoplasma gondii	ABC1 family protein	0.0035	0.0144	0.022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.002	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0144	0.0225
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0912	0.6433	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0101	0.0158
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1348	0.2096
Brugia malayi	Pre-SET motif family protein	0.0203	0.1348	0.2096
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0017	0.0011	0.0011
Leishmania major	DNA repair protein-like protein	0.0017	0.0011	0.0036
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0144	0.0225
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0101	0.0101
Trypanosoma cruzi	WLM domain containing protein, putative	0.0324	0.2219	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0011	0.0036
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Leishmania major	cytochrome p450-like protein	0.0025	0.0071	0.0306
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0144	0.0943
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0144	0.0144
Plasmodium vivax	SET domain protein, putative	0.0029	0.0101	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0324	0.2219	0.345
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.1549	0.2408
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0017	0.0011	0.0012
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0011	0.0036
Leishmania major	hypothetical protein, conserved	0.0324	0.2219	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0076	0.0435	0.0676
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0076	0.0435	0.0435
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Echinococcus multilocularis	microtubule associated protein 2	0.0673	0.4718	0.4718
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0011	0.0017
Brugia malayi	beta-lactamase family protein	0.0035	0.0144	0.0225
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0324	0.2219	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0003	0.0003
Echinococcus granulosus	ring and YY1 binding protein	0.0324	0.2219	0.2219
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0017	0.0011	0.0017
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0728	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0144	0.0225
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0144	0.0225
Echinococcus multilocularis	zinc finger protein Ran binding	0.0324	0.2219	0.2219
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0144	0.0943
Schistosoma mansoni	microtubule-associated protein tau	0.0673	0.4718	0.7335
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0017	0.0011	0.0011
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0144	0.0638
Brugia malayi	RING zinc finger protein	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Plasmodium vivax	trophozoite exported protein 1, putative	0.0017	0.0011	0.0012
Trichomonas vaginalis	esterase, putative	0.0035	0.0144	0.0225
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Brugia malayi	MH2 domain containing protein	0.0116	0.0728	0.1131
Echinococcus multilocularis	ring finger protein 113a	0.0017	0.0011	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.0083	0.0485	0.0754
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0003	0.0005
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0017	0.0011	0.0012
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0101	0.0101
Onchocerca volvulus		0.0324	0.2219	0.3438
Echinococcus multilocularis	RING finger protein 185	0.0017	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0324	0.2219	0.345
Leishmania major	hypothetical protein, conserved	0.0324	0.2219	1
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0912	0.6433	0.6433
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0101	0.0158
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0003	0.0003
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0017	0.0011	0.0012
Brugia malayi	SWIB/MDM2 domain containing protein	0.0912	0.6433	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0144	0.0144
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0144	0.0638
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Plasmodium vivax	RING zinc finger protein, putative	0.0017	0.0011	0.0012
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0017	0.0011	0.0011
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0017	0.0011	0.0011
Brugia malayi	Pre-SET motif family protein	0.0029	0.0101	0.0158
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0011	0.0017
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.0011	0.0017
Brugia malayi	beta-lactamase family protein	0.0035	0.0144	0.0225
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Plasmodium falciparum	RING zinc finger protein, putative	0.0017	0.0011	0.0012
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Brugia malayi	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0324	0.2219	1
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0912	0.6433	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma brucei	ring finger containing protein	0.0017	0.0011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0144	0.0225
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0912	0.6433	0.6433
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0017	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0101	0.0158
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0144	0.0943
Entamoeba histolytica	zinc finger domain containing protein	0.0017	0.0011	0.5
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Brugia malayi	hypothetical protein	0.0017	0.0011	0.0017
Toxoplasma gondii	hypothetical protein	0.0017	0.0011	0.0012
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0017	0.0011	0.0017
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0017	0.0011	0.0012
Brugia malayi	hypothetical protein	0.0017	0.0011	0.0017
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0144	0.0943
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0017	0.0011	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0912	0.6433	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0144	0.0225
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0017	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma brucei	hypothetical protein, conserved	0.0324	0.2219	1
Schistosoma mansoni	cellular tumor antigen P53	0.0206	0.1372	0.2133
Schistosoma mansoni	zinc finger protein	0.0324	0.2219	0.345
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0144	0.0225
Echinococcus granulosus	ring finger protein 113a	0.0017	0.0011	0.0011
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Trypanosoma cruzi	hypothetical protein, conserved	0.0324	0.2219	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.0144	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0011	0.0017
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0144	0.0943
Onchocerca volvulus		0.0324	0.2219	0.3438
Brugia malayi	hypothetical protein	0.0017	0.0011	0.0017
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0324	0.2219	1
Onchocerca volvulus		0.0206	0.1372	0.2119
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0011	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0324	0.2219	0.345
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0036
Giardia lamblia	Kinase, NEK	0.0017	0.0011	1
Plasmodium vivax	zinc finger protein, putative	0.0017	0.0011	0.0012
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0017	0.0011	0.0036
Schistosoma mansoni	peter pan-related	0.0017	0.0011	0.0017
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.1501	1
Schistosoma mansoni	mind bomb	0.0017	0.0011	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0144	0.0638
Giardia lamblia	Protein 21.1	0.0017	0.0011	1
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0017	0.0011	0.0011
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0003	0.0005
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0144	0.0225

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 8.4 uM	Concentration required for inhibition of nitric oxide production in LPS-activated mouse macrophages	ChEMBL.	10560729
IC50 (functional)	= 8.4 uM	Concentration required for inhibition of nitric oxide production in LPS-activated mouse macrophages	ChEMBL.	10560729
Inhibition (functional)	= 17.8 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 1 microM	ChEMBL.	10560729
Inhibition (functional)	= 17.8 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 1 microM	ChEMBL.	10560729
Inhibition (functional)	= 27.9 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 3 microM	ChEMBL.	10560729
Inhibition (functional)	= 27.9 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 3 microM	ChEMBL.	10560729
Inhibition (functional)	= 54.8 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 10 microM	ChEMBL.	10560729
Inhibition (functional)	= 54.8 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 10 microM	ChEMBL.	10560729
Inhibition (functional)	= 86.5 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 30 microM	ChEMBL.	10560729
Inhibition (functional)	= 86.5 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 30 microM	ChEMBL.	10560729
Inhibition (functional)	= 104 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 100 microM	ChEMBL.	10560729
Inhibition (functional)	= 104 %	Inhibition of nitric oxide production in LPS-activated mouse macrophages at a concentration of 100 microM	ChEMBL.	10560729

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	10560729

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL262708

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 173443