Detailed information for compound 1735395

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.358 | Formula: C19H19NO5
  • H donors: 1 H acceptors: 1 LogP: 3.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)c1c[nH]c2c1cc(OC)c(c2OC)OC
  • InChi: 1S/C19H19NO5/c1-22-12-7-5-6-11(8-12)17(21)14-10-20-16-13(14)9-15(23-2)18(24-3)19(16)25-4/h5-10,20H,1-4H3
  • InChiKey: OBSGUMGDTIDCGA-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0117 0.003 0.0029
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0231 0.0255 0.0277
Echinococcus granulosus c-Jun N-terminal kinases 0.5141 1 1
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0231 0.0255 0.0255
Trypanosoma cruzi 5'-AMP-activated protein kinase subunit beta, putative 0.1245 0.2269 0.275
Brugia malayi Protein kinase domain containing protein 0.0228 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0495 0.0778 0.0778
Echinococcus multilocularis activin receptor type 0.0117 0.003 0.0029
Brugia malayi chloride channel protein 7 0.0231 0.0255 0.0255
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0117 0.003 0.0029
Toxoplasma gondii IMP dehydrogenas 0.0231 0.0255 0.0893
Toxoplasma gondii histone kinase SNF1, putative 0.0569 0.0926 0.355
Brugia malayi hypothetical protein 0.0126 0.0046 0.0046
Mycobacterium ulcerans hypothetical protein 0.0231 0.0255 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0631 0.1048 0.1048
Schistosoma mansoni serine/threonine protein kinase 0.1674 0.312 0.312
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Echinococcus multilocularis protein kinase c iota type 0.0228 0.0249 0.0249
Trichomonas vaginalis AGC family protein kinase 0.0228 0.0249 0.0602
Leishmania major protein kinase A catalytic subunit 0.139 0.2555 0.3102
Echinococcus granulosus epidermal growth factor receptor 0.1132 0.2043 0.2043
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0231 0.0255 0.0255
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0231 0.0255 0.5
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0158 0.011 0.0317
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0375 0.0542 0.2029
Loa Loa (eye worm) hypothetical protein 0.0569 0.0926 0.0926
Brugia malayi CLC chloride channel protein 0.0231 0.0255 0.0255
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0228 0.0249 0.0249
Echinococcus granulosus NDR protein kinase 0.0228 0.0249 0.0249
Echinococcus granulosus H:Cl exchange transporter 4 0.0231 0.0255 0.0255
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.139 0.2555 1
Onchocerca volvulus Alicorn homolog 0.1088 0.1956 0.6212
Echinococcus granulosus mitogen activated protein kinase 14 0.422 0.8172 0.8172
Trypanosoma cruzi GMP reductase 0.0231 0.0255 0.0277
Echinococcus multilocularis 5' AMP activated protein kinase subunit beta 1 0.0668 0.1123 0.1123
Echinococcus granulosus tyrosine protein kinase HCK 0.0364 0.0519 0.0519
Echinococcus multilocularis neuroglian 0.0129 0.0052 0.0052
Plasmodium falciparum serine/threonine protein kinase KIN 0.0569 0.0926 0.355
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0231 0.0255 0.0255
Echinococcus granulosus tyrosine protein kinase Lyn 0.0602 0.0992 0.0992
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0228 0.0249 0.0249
Trypanosoma brucei developmentally regulated phosphoprotein 0.1311 0.2398 0.2909
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.139 0.2555 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0231 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0228 0.0249 0.0249
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.268 0.5116 0.5116
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0447 0.0684 0.0684
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0231 0.0255 0.0277
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0599 0.0985 0.0985
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0207 0.0207 0.0207
Leishmania major hypothetical protein, conserved 0.0231 0.0255 0.0277
Echinococcus multilocularis protein kinase c epsilon type 0.0228 0.0249 0.0249
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0231 0.0255 0.5
Schistosoma mansoni atypical protein kinase C 0.0228 0.0249 0.0249
Leishmania major inosine-5-monophosphate dehydrogenase 0.0231 0.0255 0.0277
Brugia malayi Protein kinase domain containing protein 0.5052 0.9824 0.9824
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0458 0.0706 0.0831
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0631 0.1048 0.1251
Echinococcus multilocularis serine:threonine protein kinase N2 0.0228 0.0249 0.0249
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.422 0.8172 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.0255 0.0255
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0164 0.0122 0.0122
Giardia lamblia Kinase, AGC PKA 0.0375 0.0542 0.0619
Brugia malayi Protein kinase domain containing protein 0.1912 0.3592 0.3592
Toxoplasma gondii 5'-AMP-activated protein kinase subunit beta-1 family protein, putative 0.0735 0.1255 0.4853
Trypanosoma brucei SNF1-related protein kinases, putative 0.0569 0.0926 0.1101
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0847 0.3037
Echinococcus multilocularis insulin receptor 0.0648 0.1083 0.1083
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.422 0.8172 0.8172
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.268 0.5116 0.5116
Schistosoma mansoni adapter molecule crk 0.0164 0.0122 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Echinococcus multilocularis tyrosine protein kinase Abl 0.0207 0.0207 0.0207
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0458 0.0706 0.2679
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.1311 0.2398 0.2398
Brugia malayi Furin-like cysteine rich region family protein 0.1968 0.3703 0.3703
Trypanosoma cruzi Protein kinase B 0.0375 0.0542 0.0629
Trypanosoma brucei hypothetical protein, conserved 0.0158 0.011 0.0098
Loa Loa (eye worm) hypothetical protein 0.0231 0.0255 0.0255
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0207 0.0207 0.0207
Entamoeba histolytica protein kinase, putative 0.0599 0.0985 0.3782
Echinococcus multilocularis protein kinase shaggy 0.0599 0.0985 0.0985
Echinococcus multilocularis growth factor receptor bound protein 2 0.0164 0.0122 0.0122
Loa Loa (eye worm) AGC/PKA protein kinase 0.139 0.2555 0.2555
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0569 0.0926 0.1101
Loa Loa (eye worm) hypothetical protein 0.0231 0.0255 0.0255
Brugia malayi CBS domain containing protein 0.0231 0.0255 0.0255
Echinococcus granulosus tyrosine kinase 0.0126 0.0046 0.0046
Brugia malayi kinase, mitochondrial precursor 0.1311 0.2398 0.2398
Giardia lamblia Kinase, CMGC GSK 0.0599 0.0985 0.1576
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0569 0.0926 0.0926
Schistosoma mansoni serine/threonine protein kinase 0.0631 0.1048 0.1048
Trichomonas vaginalis AGC family protein kinase 0.0228 0.0249 0.0602
Brugia malayi Protein kinase domain containing protein 0.0648 0.1083 0.1083
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.2564 0.4886 0.4886
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Leishmania major hypothetical protein, conserved,leucine-rich repeat protein, putative 0.0158 0.011 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0249 0.0249
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0528 0.0844 0.0844
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.2334 0.4428 0.4428
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0228 0.0249 0.0249
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.2564 0.4886 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.139 0.2555 1
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0249 0.0249
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1311 0.2398 0.2398
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0249 0.0249
Schistosoma mansoni growth factor receptor-bound protein 0.0164 0.0122 0.0122
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0231 0.0255 0.0255
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.139 0.2555 0.2555
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0847 0.3037
Schistosoma mansoni protein kinase subunit beta 0.0668 0.1123 0.1123
Toxoplasma gondii AGC kinase 0.139 0.2555 1
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Treponema pallidum hemolysin (tlyC) 0.0231 0.0255 1
Trypanosoma brucei AIR9-like protein 0.0158 0.011 0.0098
Schistosoma mansoni nephrin 0.0129 0.0052 0.0052
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0231 0.0255 0.0255
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0231 0.0255 0.0255
Brugia malayi hypothetical protein 0.0495 0.0778 0.0778
Echinococcus granulosus tyrosine protein kinase Srms 0.0126 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase HCK 0.0364 0.0519 0.0519
Toxoplasma gondii CBS domain-containing protein 0.0231 0.0255 0.0893
Schistosoma mansoni protein kinase subunit beta 0.1245 0.2269 0.2269
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0631 0.1048 0.1251
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0126 0.0046 0.0046
Echinococcus multilocularis mitogen activated protein kinase 11 0.422 0.8172 0.8172
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0528 0.0844 0.0844
Schistosoma mansoni chloride channel protein 0.0231 0.0255 0.0255
Schistosoma mansoni serine/threonine protein kinase 0.139 0.2555 0.2555
Loa Loa (eye worm) SRC-1 0.0528 0.0844 0.0844
Schistosoma mansoni protein kinase 0.0117 0.003 0.003
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.268 0.5116 0.5116
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0528 0.0844 0.0844
Echinococcus granulosus serine:threonine kinase SAD 1 0.0569 0.0926 0.0926
Schistosoma mansoni protein kinase 0.0117 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.139 0.2555 0.2555
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0631 0.1048 0.1251
Entamoeba histolytica protein kinase, putative 0.0529 0.0847 0.3235
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0231 0.0255 0.5
Trypanosoma brucei 5'-AMP-activated protein kinase subunit beta 0.1245 0.2269 0.275
Toxoplasma gondii glycogen synthase, putative 0.0158 0.011 0.0317
Echinococcus multilocularis NCK adaptor protein 0.0164 0.0122 0.0122
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0164 0.0122 0.0122
Leishmania major hypothetical protein, conserved 0.1245 0.2269 0.275
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.139 0.2555 0.3102
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0231 0.0255 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Echinococcus multilocularis mitogen activated protein kinase 14 0.422 0.8172 0.8172
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0228 0.0249 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0528 0.0844 0.0844
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0631 0.1048 0.1251
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0231 0.0255 0.5
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0599 0.0985 0.1173
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.139 0.2555 0.3102
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.139 0.2555 0.2555
Mycobacterium ulcerans hypothetical protein 0.0231 0.0255 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0528 0.0844 0.0844
Brugia malayi p70 ribosomal S6 kinase beta 0.0529 0.0847 0.0846
Schistosoma mansoni serine/threonine protein kinase 0.139 0.2555 0.2555
Mycobacterium ulcerans hypothetical protein 0.0231 0.0255 0.5
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.139 0.2555 0.2555
Loa Loa (eye worm) AGC/PKN protein kinase 0.0228 0.0249 0.0249
Brugia malayi Variant SH3 domain containing protein 0.0164 0.0122 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.1048 0.3858
Schistosoma mansoni protein kinase 0.0117 0.003 0.003
Onchocerca volvulus 0.152 0.2813 0.9003
Leishmania major protein kinase A catalytic subunit isoform 1 0.139 0.2555 0.3102
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0847 0.3037
Echinococcus multilocularis mitogen activated protein kinase 11 0.422 0.8172 0.8172
Loa Loa (eye worm) hypothetical protein 0.1311 0.2398 0.2398
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0042 0.0042
Echinococcus multilocularis mitogen activated protein kinase 14 0.422 0.8172 0.8172
Schistosoma mansoni tyrosine kinase 0.0207 0.0207 0.0207
Echinococcus granulosus protein kinase c epsilon type 0.0228 0.0249 0.0249
Schistosoma mansoni tyrosine kinase 0.1968 0.3703 0.3703
Echinococcus multilocularis nervana 2 0.0301 0.0394 0.0394
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0126 0.0046 0.0066
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0569 0.0926 0.1908
Echinococcus multilocularis AMPK beta subunit 0.1245 0.2269 0.2268
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.1315 0.2407 0.2407
Onchocerca volvulus Tyrosine kinase homolog 0.1589 0.295 0.9448
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0207 0.0207 0.0207
Loa Loa (eye worm) AGC/PKA protein kinase 0.139 0.2555 0.2555
Brugia malayi protein-tyrosine kinase 0.0447 0.0684 0.0684
Onchocerca volvulus 0.0599 0.0985 0.3053
Giardia lamblia 5-AMP-activated protein kinase, beta-1 subunit 0.1245 0.2269 0.4348
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0126 0.0046 0.0046
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0599 0.0985 0.0985
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Brugia malayi P38 map kinase family protein 2 0.422 0.8172 0.8172
Brugia malayi SH2 domain containing protein 0.0126 0.0046 0.0046
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.139 0.2555 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0648 0.1083 0.1083
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0231 0.0255 0.0255
Brugia malayi Variant SH3 domain containing protein 0.0164 0.0122 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0375 0.0542 0.0629
Brugia malayi intracellular kinase 0.0599 0.0985 0.0985
Echinococcus granulosus neuroglian 0.0129 0.0052 0.0052
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0231 0.0255 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0631 0.1048 0.1048
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.1048 0.3858
Brugia malayi protein kinase C II. 0.0228 0.0249 0.0249
Entamoeba histolytica protein kinase, putative 0.0364 0.0519 0.1938
Trypanosoma cruzi leucine rich repeat protein, putative 0.0158 0.011 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Entamoeba histolytica protein kinase, putative 0.0228 0.0249 0.087
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.139 0.2555 0.3102
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.1315 0.2407 0.2407
Echinococcus multilocularis serine:threonine protein kinase N2 0.0228 0.0249 0.0249
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.139 0.2555 0.3102
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.139 0.2555 0.3102
Echinococcus granulosus serine:threonine protein kinase N2 0.0228 0.0249 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Loa Loa (eye worm) hypothetical protein 0.0231 0.0255 0.0255
Schistosoma mansoni protein kinase subunit beta 0.0158 0.011 0.011
Echinococcus granulosus protein kinase c iota type 0.0228 0.0249 0.0249
Echinococcus multilocularis mitogen activated protein kinase 0.0631 0.1048 0.1048
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0375 0.0542 0.0542
Schistosoma mansoni serine/threonine protein kinase 0.0569 0.0926 0.0926
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.139 0.2555 0.3102
Schistosoma mansoni pyruvate dehydrogenase 0.1311 0.2398 0.2398
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.1912 0.3592 0.3592
Schistosoma mansoni serine/threonine protein kinase 0.139 0.2555 0.2555
Echinococcus granulosus tyrosine protein kinase Fyn 0.0528 0.0844 0.0844
Loa Loa (eye worm) hypothetical protein 0.0162 0.0118 0.0118
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0231 0.0255 0.5
Giardia lamblia Kinase, CAMK CAMKL 0.0569 0.0926 0.1449
Schistosoma mansoni protein kinase subunit gamma 0.2564 0.4886 0.4886
Echinococcus granulosus nervana 2 0.0301 0.0394 0.0394
Echinococcus granulosus 5' AMP activated protein kinase subunit beta 1 0.0668 0.1123 0.1123
Echinococcus granulosus protein kinase C gamma type 0.0228 0.0249 0.0249
Toxoplasma gondii AGC kinase 0.0529 0.0847 0.3235
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0231 0.0255 0.0277
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0528 0.0844 0.0844
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0231 0.0255 0.0277
Trypanosoma cruzi SNF1-related protein kinase regulatory subunit beta, putative 0.1245 0.2269 0.275
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0528 0.0844 0.0844
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.139 0.2555 0.2555
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.139 0.2555 0.2555
Loa Loa (eye worm) hypothetical protein 0.0158 0.011 0.0109
Entamoeba histolytica PH domain containing protein kinase, putative 0.139 0.2555 1
Brugia malayi Protein kinase domain containing protein 0.0126 0.0046 0.0046
Brugia malayi Protein kinase domain containing protein 0.0126 0.0046 0.0046
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0569 0.0926 0.0926
Echinococcus multilocularis Glutaredoxin protein 5 0.0301 0.0394 0.0394
Schistosoma mansoni vesicular amine transporter 0.0105 0.0005 0.0005
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0228 0.0249 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.0569 0.0926 0.0926
Schistosoma mansoni tyrosine kinase 0.1089 0.1958 0.1958
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1699 0.3168 0.3168
Toxoplasma gondii serine/threonine specific protein phosphatase 0.0158 0.011 0.0317
Brugia malayi Protein kinase domain containing protein 0.0126 0.0046 0.0046
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0231 0.0255 0.5
Plasmodium vivax glycogen synthase kinase 3, putative 0.0599 0.0985 0.22
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0231 0.0255 0.0277
Leishmania major chloride channel protein, putative 0.0231 0.0255 0.0277
Schistosoma mansoni serine/threonine kinase 0.0228 0.0249 0.0249
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0231 0.0255 0.5
Giardia lamblia Kinase, CMGC GSK 0.0599 0.0985 0.1576
Echinococcus granulosus Protein kinase C brain isozyme 0.0228 0.0249 0.0249
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0231 0.0255 0.0277
Echinococcus granulosus epidermal growth factor receptor 0.1968 0.3703 0.3703
Echinococcus multilocularis c src tyrosine kinase 0.0207 0.0207 0.0207
Schistosoma mansoni tyrosine kinase 0.0126 0.0046 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Schistosoma mansoni serine/threonine-protein kinase 0.0375 0.0542 0.0542
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0231 0.0255 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0447 0.0684 0.0684
Brugia malayi Sex muscle abnormal protein 5 0.0164 0.0122 0.0122
Echinococcus granulosus H:Cl exchange transporter 7 0.0231 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0495 0.0778 0.0778
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0249 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Schistosoma mansoni tyrosine kinase 0.1132 0.2043 0.2043
Entamoeba histolytica protein kinase, putative 0.0157 0.0109 0.0315
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0458 0.0706 0.0831
Echinococcus granulosus Glutaredoxin protein 5 0.0301 0.0394 0.0394
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0228 0.0249 0.0249
Echinococcus granulosus serine/threonine protein kinase 0.0375 0.0542 0.0542
Onchocerca volvulus 0.16 0.2972 0.9519
Loa Loa (eye worm) IMP dehydrogenase 1 0.0231 0.0255 0.0255
Toxoplasma gondii IQ calmodulin-binding motif domain-containing protein 0.0158 0.011 0.0317
Echinococcus granulosus roundabout 2 0.0162 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0162 0.0118 0.0118
Trypanosoma brucei protein kinase, putative 0.0631 0.1048 0.1251
Entamoeba histolytica protein kinase, putative 0.0529 0.0847 0.3235
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0631 0.1048 0.1251
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0599 0.0985 0.0985
Trichomonas vaginalis CMGC family protein kinase 0.0599 0.0985 0.36
Plasmodium falciparum glycogen synthase kinase 3 0.0599 0.0985 0.3782
Brugia malayi ancient conserved domain protein 4 0.0231 0.0255 0.0255
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0228 0.0249 0.0249
Echinococcus granulosus tyrosine protein kinase Src42A 0.0404 0.0599 0.0598
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Brugia malayi Protein kinase domain containing protein 0.0228 0.0249 0.0249
Toxoplasma gondii CBS family protein 0.0231 0.0255 0.0893
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0569 0.0926 0.0926
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0631 0.1048 0.1251
Treponema pallidum Mg2+ transport protein (mgtE) 0.0231 0.0255 1
Toxoplasma gondii CBS domain-containing protein 0.0231 0.0255 0.0893
Giardia lamblia Kinase, AGC PKA 0.139 0.2555 0.4966
Trypanosoma cruzi chloride channel protein, putative 0.0231 0.0255 0.0277
Loa Loa (eye worm) AGC/NDR protein kinase 0.0228 0.0249 0.0249
Leishmania major guanosine monophosphate reductase 0.0231 0.0255 0.0277
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0231 0.0255 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.1699 0.3168 0.3168
Schistosoma mansoni tyrosine kinase 0.1089 0.1958 0.1958
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.422 0.8172 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.1311 0.2398 0.2909
Schistosoma mansoni growth factor receptor-bound protein 0.0164 0.0122 0.0122
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0648 0.1083 0.1083
Echinococcus granulosus serine threonine protein kinase nrc 0.0375 0.0542 0.0542
Brugia malayi SRC-1 0.0528 0.0844 0.0844
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0847 0.3037
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.268 0.5116 0.5116
Loa Loa (eye worm) chloride channel 3 0.0231 0.0255 0.0255
Leishmania major chloride channel protein, putative 0.0231 0.0255 0.0277
Echinococcus multilocularis serine:threonine protein kinase 38 0.0228 0.0249 0.0249
Schistosoma mansoni tyrosine kinase 0.0207 0.0207 0.0207
Echinococcus multilocularis c Jun NH2 terminal kinase 0.5141 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.1238 0.2253 0.2253
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0228 0.0249 0.0249
Loa Loa (eye worm) 5'-AMP-activated protein kinase 0.1245 0.2269 0.2268
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.2564 0.4886 0.4886
Onchocerca volvulus 0.1674 0.312 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0231 0.0255 0.5
Echinococcus granulosus NCK adaptor protein 0.0164 0.0122 0.0122
Trypanosoma cruzi GMP reductase 0.0231 0.0255 0.0277
Entamoeba histolytica protein kinase, putative 0.0529 0.0847 0.3235
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0569 0.0926 0.1101
Giardia lamblia Kinase, CMGC MAPK 0.0631 0.1048 0.1713
Entamoeba histolytica PH domain containing protein kinase, putative 0.0375 0.0542 0.2029
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0231 0.0255 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0164 0.0122 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Echinococcus granulosus tyrosine protein kinase ABL1 0.0126 0.0046 0.0046
Echinococcus multilocularis epidermal growth factor receptor 0.1132 0.2043 0.2043
Trypanosoma cruzi chloride channel protein, putative 0.0231 0.0255 0.0277
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0599 0.0985 0.0985
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0569 0.0926 0.1101
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0134 0.0063 0.0063
Chlamydia trachomatis CBS domain-containing protein 0.0231 0.0255 0.5
Schistosoma mansoni serine/threonine-protein kinase 0.0375 0.0542 0.0542
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1311 0.2398 0.2398
Schistosoma mansoni tyrosine kinase 0.0126 0.0046 0.0046
Echinococcus granulosus rho-associated protein kinase 1 0.1674 0.312 0.312
Brugia malayi Protein kinase domain containing protein 0.0126 0.0046 0.0046
Loa Loa (eye worm) TK/INSR protein kinase 0.0648 0.1083 0.1083
Trichomonas vaginalis CMGC family protein kinase 0.0599 0.0985 0.36
Chlamydia trachomatis Mg++ transporter 0.0231 0.0255 0.5
Echinococcus granulosus AMPK beta subunit 0.1245 0.2269 0.2268
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0164 0.0122 0.0122
Plasmodium falciparum protein MAM3, putative 0.0231 0.0255 0.0893
Onchocerca volvulus 0.0155 0.0105 0.0191
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0228 0.0249 0.0249
Echinococcus multilocularis tyrosine protein kinase shark 0.0126 0.0046 0.0046
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0231 0.0255 0.0277
Schistosoma mansoni nck2/grb4 0.0164 0.0122 0.0122
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0136 0.0066 0.0066
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Mycobacterium ulcerans transcriptional regulator 0.0231 0.0255 0.5
Onchocerca volvulus 0.0231 0.0255 0.0679
Loa Loa (eye worm) TK protein kinase 0.0364 0.0519 0.0519
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0231 0.0255 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0249 0.0249
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0231 0.0255 0.0277
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0528 0.0844 0.0844
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0157 0.0109 0.0315
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0231 0.0255 0.0255
Echinococcus multilocularis tyrosine protein kinase Srms 0.0447 0.0684 0.0684
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0231 0.0255 0.0255
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0528 0.0844 0.0844
Giardia lamblia Kinase, CAMK CAMKL 0.0569 0.0926 0.1449
Brugia malayi Voltage gated chloride channel family protein 0.0231 0.0255 0.0255
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.422 0.8172 1
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Schistosoma mansoni serine/threonine protein kinase 0.0569 0.0926 0.0926
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0599 0.0985 0.3782
Entamoeba histolytica protein kinase domain containing protein 0.0599 0.0985 0.3782
Mycobacterium leprae conserved hypothetical protein 0.0231 0.0255 0.5
Leishmania major CBS domain protein, conserved 0.0231 0.0255 0.0277
Echinococcus multilocularis serine threonine protein kinase 0.0228 0.0249 0.0249
Echinococcus granulosus tm gpcr rhodopsin 0.4858 0.9438 0.9438
Loa Loa (eye worm) AGC/AKT protein kinase 0.0529 0.0847 0.0846
Trichomonas vaginalis CAMK family protein kinase 0.0569 0.0926 0.3361
Trypanosoma brucei GMP reductase 0.0231 0.0255 0.0277
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0599 0.0985 0.0985
Entamoeba histolytica serine/threonine protein kinase, putative 0.0569 0.0926 0.355
Mycobacterium tuberculosis Conserved protein 0.0231 0.0255 0.5
Schistosoma mansoni tyrosine kinase 0.0528 0.0844 0.0844
Toxoplasma gondii AGC kinase 0.139 0.2555 1
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0231 0.0255 0.0893
Brugia malayi MAP kinase sur-1 0.0631 0.1048 0.1048
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0231 0.0255 0.0277
Echinococcus multilocularis 0.0687 0.1161 0.1161
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0231 0.0255 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4858 0.9438 0.9438
Echinococcus granulosus tyrosine protein kinase Src42A 0.0528 0.0844 0.0844
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0631 0.1048 0.4033
Echinococcus granulosus c src tyrosine kinase 0.0207 0.0207 0.0207
Trypanosoma cruzi chloride channel protein, putative 0.0231 0.0255 0.0277
Loa Loa (eye worm) loechrig isoform VII 0.2564 0.4886 0.4886
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0631 0.1048 0.1251
Trichomonas vaginalis AGC family protein kinase 0.0228 0.0249 0.0602
Echinococcus multilocularis nervana 2 0.0301 0.0394 0.0394
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0231 0.0255 0.0255
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.5052 0.9824 0.9824
Mycobacterium ulcerans cystathionine beta-synthase 0.0231 0.0255 0.5
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.139 0.2555 0.2555
Brugia malayi Hr1 repeat family protein 0.0228 0.0249 0.0249
Brugia malayi Protein kinase domain containing protein 0.0126 0.0046 0.0046
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0528 0.0844 0.0844
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0231 0.0255 0.0255
Echinococcus granulosus tyrosine kinase 0.0447 0.0684 0.0684
Trichomonas vaginalis AGC family protein kinase 0.139 0.2555 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.139 0.2555 0.3102
Echinococcus granulosus H:Cl exchange transporter 3 0.0231 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0164 0.0122 0.0122
Trichomonas vaginalis AGC family protein kinase 0.0228 0.0249 0.0602
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0528 0.0844 0.0844
Schistosoma mansoni tyrosine kinase 0.0528 0.0844 0.0844
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1132 0.2043 0.2043
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0231 0.0255 0.0255
Brugia malayi putative serine/threonine kinase SADA gamma 0.0569 0.0926 0.0926
Schistosoma mansoni chloride channel protein 0.0231 0.0255 0.0255
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Loa Loa (eye worm) chloride channel protein 7 0.0231 0.0255 0.0255
Brugia malayi Tyrosine-protein kinase abl-1 0.0207 0.0207 0.0207
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0531 0.0851 0.3251
Schistosoma mansoni tyrosine kinase 0.1132 0.2043 0.2043
Entamoeba histolytica protein kinase 2, putative 0.0375 0.0542 0.2029
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0569 0.0926 0.1101
Loa Loa (eye worm) TK protein kinase 0.0447 0.0684 0.0684
Schistosoma mansoni serine/threonine protein kinase 0.268 0.5116 0.5116
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0301 0.0394 0.0394
Echinococcus multilocularis roundabout 2 0.0162 0.0118 0.0118
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0599 0.0985 0.1173
Echinococcus granulosus activin receptor type 0.0117 0.003 0.0029
Echinococcus multilocularis rac serine:threonine kinase 0.0375 0.0542 0.0542
Loa Loa (eye worm) TK/EGFR protein kinase 0.1968 0.3703 0.3703
Loa Loa (eye worm) hypothetical protein 0.0136 0.0066 0.0066
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0231 0.0255 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0528 0.0844 0.0844
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0301 0.0394 0.0394
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0458 0.0706 0.0831
Brugia malayi SH2 domain containing protein 0.0126 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.1089 0.1958 0.1958
Echinococcus granulosus tyrosine protein kinase shark 0.0126 0.0046 0.0046
Entamoeba histolytica protein kinase domain containing protein 0.0599 0.0985 0.3782
Echinococcus granulosus mitogen activated protein kinase 0.0631 0.1048 0.1048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0447 0.0684 0.0684
Mycobacterium tuberculosis Conserved protein 0.0231 0.0255 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0528 0.0844 0.0844
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.1048 0.3858
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0249 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0249 0.0249
Trypanosoma brucei protein kinase, putative 0.0599 0.0985 0.1173
Echinococcus granulosus tyrosine protein kinase Fyn 0.0528 0.0844 0.0844
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0126 0.0046 0.0046
Echinococcus granulosus nervana 2 0.0301 0.0394 0.0394
Mycobacterium tuberculosis Conserved protein 0.0231 0.0255 0.5
Schistosoma mansoni serine/threonine protein kinase 0.5141 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0529 0.0847 0.1003
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.5141 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0529 0.0847 0.0846
Loa Loa (eye worm) TK/FER protein kinase 0.0126 0.0046 0.0046
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0231 0.0255 0.5
Brugia malayi loechrig isoform VII 0.2564 0.4886 0.4886
Echinococcus multilocularis tyrosine kinase 0.0126 0.0046 0.0046
Echinococcus granulosus insulin receptor 0.0648 0.1083 0.1083
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.422 0.8172 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0631 0.1048 0.1048
Echinococcus multilocularis rho associated protein kinase 0.1674 0.312 0.312
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.1245 0.2269 0.2268
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.139 0.2555 0.3102
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.139 0.2555 0.2555
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.1245 0.2269 0.2268
Schistosoma mansoni serine/threonine protein kinase 0.1912 0.3592 0.3592
Echinococcus granulosus tyrosine protein kinase Blk 0.0447 0.0684 0.0684
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0569 0.0926 0.1101
Trypanosoma cruzi chloride channel protein, putative 0.0231 0.0255 0.0277
Loa Loa (eye worm) TK/ABL protein kinase 0.0126 0.0046 0.0046
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.139 0.2555 0.2555
Brugia malayi ancient conserved domain protein 2 0.0231 0.0255 0.0255
Entamoeba histolytica PH domain containing protein kinase, putative 0.0375 0.0542 0.2029
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0231 0.0255 0.5
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0847 0.3037
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0375 0.0542 0.0542
Schistosoma mansoni tyrosine kinase 0.0648 0.1083 0.1083
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0228 0.0249 0.0249
Toxoplasma gondii hypothetical protein 0.0158 0.011 0.0317
Loa Loa (eye worm) hypothetical protein 0.0126 0.0046 0.0046
Echinococcus granulosus twitchin 0.0203 0.02 0.02
Schistosoma mansoni pyruvate dehydrogenase 0.1238 0.2253 0.2253
Schistosoma mansoni cell adhesion molecule 0.0136 0.0066 0.0066
Echinococcus multilocularis epidermal growth factor receptor 0.1968 0.3703 0.3703
Echinococcus granulosus mitogen activated protein kinase 11 0.422 0.8172 0.8172
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0847 0.3037
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0228 0.0249 0.0249
Schistosoma mansoni tyrosine kinase 0.0648 0.1083 0.1083
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.1048 0.3858
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0404 0.0599 0.0598
Schistosoma mansoni chloride channel protein 0.0231 0.0255 0.0255
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0375 0.0542 0.0629
Brugia malayi Protein kinase domain containing protein 0.0529 0.0847 0.0846
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0847 0.3037
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.1311 0.2398 0.2909
Echinococcus granulosus protein kinase shaggy 0.0599 0.0985 0.0985

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10000 nM Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay ChEMBL. 23360369

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23360369

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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