TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.336 | Formula: C23H12F2O4
H donors: 2 H acceptors: 3 LogP: 5.93 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cc(F)cc(c1)C#Cc1c(oc2c1cc(C(=O)O)c(c2)O)c1ccccc1
InChi: 1S/C23H12F2O4/c24-15-8-13(9-16(25)10-15)6-7-17-18-11-19(23(27)28)20(26)12-21(18)29-22(17)14-4-2-1-3-5-14/h1-5,8-12,26H,(H,27,28)
InChiKey: QRYRNLXHTNVLET-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, receptor type, F	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 7	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, receptor type, A	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, receptor type, C	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	Starlite/ChEMBL	References
Homo sapiens	dual specificity phosphatase 3	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 2	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 9	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, receptor type, G	Starlite/ChEMBL	References
Homo sapiens	acid phosphatase 1, soluble	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 6	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 1	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 11	Starlite/ChEMBL	References
Homo sapiens	dual specificity phosphatase 22	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	tyrosine specific protein phosphatase, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	Get druggable targets OG5_127571	All targets in OG5_127571
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	Get druggable targets OG5_141408	All targets in OG5_141408
Echinococcus multilocularis	sortilin receptor	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	ko:K05695 protein tyrosine phosphatase, receptor type, F, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	Dual specificity protein phosphatase 22-A, putative	Get druggable targets OG5_131563	All targets in OG5_131563
Schistosoma japonicum	Tyrosine-protein phosphatase 99A precursor, putative	Get druggable targets OG5_130306	All targets in OG5_130306
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	Get druggable targets OG5_128637	All targets in OG5_128637
Leishmania infantum	tyrosine specific protein phosphatase, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	Get druggable targets OG5_128637	All targets in OG5_128637
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_134130	All targets in OG5_134130
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_133865	All targets in OG5_133865
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	Get druggable targets OG5_134995	All targets in OG5_134995
Entamoeba histolytica	protein tyrosine phosphatase, putative	Get druggable targets OG5_130306	All targets in OG5_130306
Schistosoma japonicum	Receptor-type tyrosine-protein phosphatase S precursor, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128637	All targets in OG5_128637
Entamoeba histolytica	protein tyrosine phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus granulosus	dual specificity protein phosphatase	Get druggable targets OG5_131563	All targets in OG5_131563
Schistosoma mansoni	dual specificity protein phosphatase	Get druggable targets OG5_131563	All targets in OG5_131563
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma mansoni	receptor protein tyrosine phosphatase	Get druggable targets OG5_130306	All targets in OG5_130306
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus granulosus	receptor type tyrosine protein phosphatase	Get druggable targets OG5_128637	All targets in OG5_128637
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	IPR003961,Fibronectin, type III;IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_128637	All targets in OG5_128637
Onchocerca volvulus		Get druggable targets OG5_135820	All targets in OG5_135820
Brugia malayi	Ferm domain	Get druggable targets OG5_135820	All targets in OG5_135820
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	Get druggable targets OG5_128637	All targets in OG5_128637
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	Get druggable targets OG5_127571	All targets in OG5_127571
Echinococcus multilocularis	dual specificity protein phosphatase	Get druggable targets OG5_131563	All targets in OG5_131563
Schistosoma japonicum	IPR000242,Tyrosine specific protein phosphatase,domain-containing	Get druggable targets OG5_130331	All targets in OG5_130331
Schistosoma japonicum	Tyrosine-protein phosphatase Lar precursor, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	Receptor-type tyrosine-protein phosphatase F precursor, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_134130	All targets in OG5_134130
Loa Loa (eye worm)	dual specificity phosphatase	Get druggable targets OG5_131563	All targets in OG5_131563
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	Get druggable targets OG5_128637	All targets in OG5_128637
Leishmania major	tyrosine specific protein phosphatase, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	Get druggable targets OG5_132665	All targets in OG5_132665
Schistosoma japonicum	ko:K06777 protein tyrosine phosphatase, receptor type, D, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus multilocularis	protein tyrosine phosphatase n9	Get druggable targets OG5_134130	All targets in OG5_134130
Echinococcus granulosus	receptor type tyrosine protein phosphatase	Get druggable targets OG5_132665	All targets in OG5_132665
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135820	All targets in OG5_135820
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	Get druggable targets OG5_127571	All targets in OG5_127571
Onchocerca volvulus		Get druggable targets OG5_128637	All targets in OG5_128637
Echinococcus granulosus	receptor type tyrosine protein phosphatase	Get druggable targets OG5_132665	All targets in OG5_132665
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Entamoeba histolytica	dual specificity protein phosphatase, putative	Get druggable targets OG5_134995	All targets in OG5_134995
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	Get druggable targets OG5_128637	All targets in OG5_128637
Onchocerca volvulus		Get druggable targets OG5_127571	All targets in OG5_127571
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	Get druggable targets OG5_128637	All targets in OG5_128637
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Giardia lamblia	Dual specificity phosphatase, catalytic	Get druggable targets OG5_131563	All targets in OG5_131563
Candida albicans	C terminus of potential Low molecular weight phosphoTyrosine Phosphatase	Get druggable targets OG5_127571	All targets in OG5_127571
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	Get druggable targets OG5_134130	All targets in OG5_134130
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	Get druggable targets OG5_127571	All targets in OG5_127571
Leishmania mexicana	tyrosine specific protein phosphatase, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	IPR000340,Dual specificity protein phosphatase,domain-containing	Get druggable targets OG5_131563	All targets in OG5_131563
Schistosoma japonicum	Receptor-type tyrosine-protein phosphatase delta precursor, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_133865	All targets in OG5_133865
Entamoeba histolytica	protein tyrosine phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Brugia malayi	Dual specificity phosphatase, catalytic domain containing protein	Get druggable targets OG5_131563	All targets in OG5_131563
Schistosoma japonicum	ko:K07293 protein tyrosine phosphatase, non-receptor type 11, putative	Get druggable targets OG5_130331	All targets in OG5_130331
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	Get druggable targets OG5_127571	All targets in OG5_127571
Schistosoma japonicum	Receptor-type tyrosine-protein phosphatase S precursor, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	Tyrosine-protein phosphatase non-receptor type 9, putative	Get druggable targets OG5_134130	All targets in OG5_134130
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	Get druggable targets OG5_130306	All targets in OG5_130306
Echinococcus granulosus	receptor type tyrosine protein phosphatase	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	Get druggable targets OG5_130306	All targets in OG5_130306
Onchocerca volvulus		Get druggable targets OG5_131563	All targets in OG5_131563
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	Get druggable targets OG5_130331	All targets in OG5_130331
Loa Loa (eye worm)	fibronectin type III domain-containing protein	Get druggable targets OG5_128637	All targets in OG5_128637
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	Get druggable targets OG5_127571	All targets in OG5_127571
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Leishmania braziliensis	tyrosine specific protein phosphatase, putative	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	Get druggable targets OG5_128637	All targets in OG5_128637
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	Get druggable targets OG5_133865	All targets in OG5_133865
Candida albicans	3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene	Get druggable targets OG5_127571	All targets in OG5_127571

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des)	acid phosphatase 1, soluble	112 aa	107 aa	24.3 %
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	protein tyrosine phosphatase, receptor type, A	802 aa	657 aa	31.2 %
Mycobacterium tuberculosis	Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase)	protein tyrosine phosphatase, receptor type, C	87 aa	85 aa	25.9 %
Brugia malayi	Dual specificity phosphatase, catalytic domain containing protein	dual specificity phosphatase 22	205 aa	175 aa	31.4 %
Schistosoma mansoni	protein tyrosine phosphatase	protein tyrosine phosphatase, non-receptor type 2	410 aa	335 aa	25.7 %
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	protein tyrosine phosphatase, non-receptor type 9	593 aa	493 aa	22.1 %
Trypanosoma brucei	kinetoplastid-specific dual specificity phosphatase, putative	dual specificity phosphatase 3	185 aa	182 aa	25.3 %
Echinococcus granulosus	receptor type tyrosine protein phosphatase	protein tyrosine phosphatase, non-receptor type 7	434 aa	400 aa	24.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0501	0.6326	1
Brugia malayi	Dual specificity phosphatase, catalytic domain containing protein	0.0201	0.2444	0.3863
Echinococcus granulosus	carbonic anhydrase	0.0017	0.006	0.006
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.1156
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0012	0.0002	0.0003
Loa Loa (eye worm)	projectin	0.0012	0.0002	0.0003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0226	0.2764	0.2465
Brugia malayi	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0017	0.006	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0089	0.0993	0.3592
Schistosoma mansoni	titin	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0089	0.0993	0.3592
Schistosoma mansoni	neuroglian	0.0012	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.1156
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	hypothetical protein	0.0089	0.0993	0.1569
Schistosoma mansoni	titin	0.0012	0.0002	0.0003
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0226	0.276	0.3087
Loa Loa (eye worm)	hypothetical protein	0.0017	0.006	0.0095
Onchocerca volvulus		0.0089	0.0993	0.3592
Onchocerca volvulus		0.0089	0.0993	0.3592
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0017	0.006	0.0095
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.007	0.0744	0.7328
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.1433	0.1669
Echinococcus granulosus	carbonic anhydrase II	0.0017	0.006	0.006
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0703	0.8939	1
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.009	0.1011	0.1598
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.1156
Onchocerca volvulus		0.0089	0.0993	0.3592
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0123	0.1433	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0017	0.006	0.0095
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.0993
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Schistosoma mansoni	protein tyrosine phosphatase	0.0089	0.0993	0.1569
Echinococcus granulosus	dual specificity protein phosphatase	0.0201	0.2444	0.2444
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0017	0.006	0.0095
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0017	0.006	0.0095
Echinococcus granulosus	contactin	0.0012	0.0002	0.0002
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.0993
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0089	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0234	0.2872	0.3344
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0223	0.273	0.3179
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Schistosoma mansoni	protein tyrosine phosphatase	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0501	0.6326	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.036	0.45	0.524
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Schistosoma mansoni	pcd6 interacting protein-related	0.0089	0.0993	0.1569
Onchocerca volvulus		0.0095	0.1077	0.3898
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Schistosoma mansoni	dual specificity protein phosphatase	0.0201	0.2444	0.3863
Schistosoma mansoni	nephrin	0.0012	0.0002	0.0003
Onchocerca volvulus	4.1 G protein, putative homolog	0.0094	0.1056	0.3819
Echinococcus multilocularis	carbonic anhydrase	0.0017	0.006	0.007
Loa Loa (eye worm)	carbonic anhydrase 3	0.0017	0.006	0.0095
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.0993
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0089	0.0993	0.7679
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0111	0.1275	0.1484
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0226	0.2764	0.2465
Echinococcus multilocularis		0.0089	0.0993	0.1156
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0089	0.0993	0.3592
Echinococcus multilocularis	carbonic anhydrase	0.0017	0.006	0.007
Brugia malayi	hypothetical protein	0.0089	0.0993	0.1569
Onchocerca volvulus		0.0012	0.0002	0.0007
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0089	0.0993	0.0993
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0017	0.006	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Echinococcus granulosus	nephrin	0.0012	0.0002	0.0002
Onchocerca volvulus		0.0111	0.1275	0.4612
Echinococcus multilocularis	titin	0.0012	0.0002	0.0002
Onchocerca volvulus		0.0089	0.0993	0.3592
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0119	0.1387	0.1615
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0119	0.1387	0.2192
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0089	0.0993	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0234	0.2872	0.2872
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0089	0.0993	0.1569
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0156	0.1864	0.5
Onchocerca volvulus		0.0012	0.0002	0.0007
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.036	0.45	0.45
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Schistosoma mansoni	carbonic anhydrase-related	0.0017	0.006	0.0095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0501	0.6326	1
Echinococcus granulosus	titin	0.0012	0.0002	0.0002
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0089	0.0993	0.1569
Echinococcus granulosus	carbonic anhydrase	0.0017	0.006	0.006
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0089	0.0993	0.0993
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.036	0.45	0.7113
Toxoplasma gondii	hypothetical protein	0.0017	0.006	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1077	0.1703
Echinococcus granulosus	roundabout 2	0.0012	0.0002	0.0002
Echinococcus multilocularis	neuroglian	0.0012	0.0002	0.0002
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.1433	0.1433
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0703	0.8939	1
Brugia malayi	Protein-tyrosine phosphatase 1	0.009	0.1011	0.1598
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Leishmania major	hypothetical protein, conserved	0.007	0.0744	0.5627
Onchocerca volvulus		0.0089	0.0993	0.3592
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0111	0.1275	0.1484
Echinococcus multilocularis	hypothetical protein	0.0089	0.0993	0.1156
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0226	0.2764	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.036	0.45	0.7113
Loa Loa (eye worm)	dual specificity phosphatase	0.0201	0.2444	0.3863
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0017	0.006	0.0095
Leishmania major	tyrosine specific protein phosphatase, putative	0.0111	0.1275	1
Schistosoma mansoni	carbonic anhydrase	0.0017	0.006	0.0095
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0012	0.0002	0.0003
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.1433	0.1433
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0223	0.2732	0.2732
Echinococcus granulosus	roundabout 2	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0003
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0111	0.1275	0.1484
Echinococcus granulosus	roundabout 2	0.0012	0.0002	0.0002
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0226	0.2764	0.2465
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0744	0.5627
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0685	0.87	0.87
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Schistosoma mansoni	carbonic anhydrase-related	0.0017	0.006	0.0095
Echinococcus granulosus	titin	0.0012	0.0002	0.0002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0017	0.006	0.0095
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0744	0.5627
Onchocerca volvulus		0.0089	0.0993	0.3592
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0089	0.0993	0.0993
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0201	0.2444	0.8843
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0111	0.1275	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0234	0.2872	0.454
Brugia malayi	Protein-tyrosine phosphatase	0.0098	0.1105	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0226	0.2764	0.4369
Echinococcus multilocularis	roundabout 2	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.003	0.0237	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0172	0.0271
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0226	0.2764	0.3092
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0226	0.2764	0.2465
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0111	0.1275	0.2015
Trichomonas vaginalis	pten, drome, putative	0.0089	0.0993	0.0304
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	roundabout 2	0.0012	0.0002	0.0002
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0089	0.0995	0.1573
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0501	0.6326	0.6326
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Schistosoma mansoni	hypothetical protein	0.0017	0.006	0.0095
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0501	0.6326	0.7367
Echinococcus granulosus	carbonic anhydrase	0.0017	0.006	0.006
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0676	0.8588	1
Schistosoma mansoni	carbonic anhydrase-related	0.0017	0.006	0.0095
Onchocerca volvulus		0.0089	0.0993	0.3592
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0098	0.1105	0.1747
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Plasmodium falciparum	carbonic anhydrase	0.0017	0.006	0.5
Onchocerca volvulus		0.0089	0.0993	0.3592
Echinococcus granulosus	neuroglian	0.0012	0.0002	0.0002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Echinococcus multilocularis	carbonic anhydrase	0.0017	0.006	0.007
Onchocerca volvulus		0.0089	0.0993	0.3592
Onchocerca volvulus		0.0012	0.0002	0.0007
Echinococcus multilocularis	dual specificity protein phosphatase	0.0201	0.2444	0.2846
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0226	0.2764	0.2465
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0089	0.0993	0.7679
Echinococcus multilocularis	roundabout 2	0.0012	0.0002	0.0002
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0123	0.1433	0.2266
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0119	0.1387	0.2192
Brugia malayi	Ferm domain	0.0095	0.1077	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0226	0.2764	0.2465
Schistosoma mansoni	myosin-binding protein-related	0.0012	0.0002	0.0003
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0226	0.2764	0.3092
Schistosoma mansoni	nephrin	0.0012	0.0002	0.0003
Schistosoma mansoni	protein tyrosine phosphatase	0.0098	0.1105	0.1747
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0089	0.0993	1
Onchocerca volvulus		0.0089	0.0993	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Echinococcus multilocularis	carbonic anhydrase II	0.0017	0.006	0.007
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.036	0.45	0.524
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	transfer RNA-Phe	0.0012	0.0002	0.0002
Onchocerca volvulus		0.0089	0.0993	0.3592
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0089	0.0993	0.1569
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0002	0.0003
Brugia malayi	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0089	0.0993	0.0993
Onchocerca volvulus		0.0089	0.0993	0.3592
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0089	0.0993	0.0993
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0017	0.006	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0017	0.006	0.0095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Onchocerca volvulus		0.0089	0.0993	0.3592
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Giardia lamblia	Dual specificity phosphatase, catalytic	0.0201	0.2444	0.8194
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0017	0.006	0.0095
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Schistosoma mansoni	hemicentin	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0089	0.0993	0.3592
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.1433	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.009	0.1011	0.1177
Loa Loa (eye worm)	CAMK protein kinase	0.0012	0.0002	0.0003
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0119	0.1387	0.1615
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.036	0.45	0.7113
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0223	0.2732	0.3181
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0089	0.0993	0.1569
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0089	0.0993	0.1156
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0226	0.2764	0.5
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0223	0.2732	0.4318
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.009	0.1011	0.1011
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0017	0.006	0.0095
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0089	0.0993	0.1111
Onchocerca volvulus		0.0089	0.0993	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0012	0.0002	0.0002
Brugia malayi	Protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0226	0.2764	0.4369
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0089	0.0993	0.1569
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0119	0.1387	0.2192
Onchocerca volvulus		0.0089	0.0993	0.3592
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0111	0.1275	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0089	0.0993	0.1569
Echinococcus multilocularis	sortilin receptor	0.0022	0.0125	0.0146
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0089	0.0993	0.3592
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.036	0.45	0.45
Onchocerca volvulus		0.0226	0.2764	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0017	0.006	0.0095
Onchocerca volvulus		0.0089	0.0993	0.3592
Brugia malayi	hypothetical protein	0.0089	0.0993	0.1569
Onchocerca volvulus		0.0089	0.0993	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0993	0.1569
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0676	0.8588	0.8588
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Brugia malayi	protein unc-22	0.0012	0.0002	0.0003
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0089	0.0993	0.1111
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0089	0.0993	0.1569

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.3 uM	Inhibition of LYP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 1.3 uM	Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by spectrophotometric analysis	ChEMBL.	23713581
IC50 (binding)	= 1.9 uM	Inhibition of FAP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 2.2 uM	Inhibition of SHP2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 2.3 uM	Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 2.3 uM	Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 2.9 uM	Inhibition of LMWPTP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 2.9 uM	Inhibition of VHX (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 3.3 uM	Inhibition of HEPTP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 4.1 uM	Inhibition of CD45 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 4.5 uM	Inhibition of PTP1B (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 5 uM	Inhibition of PTPgamma (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 5.3 uM	Inhibition of VHR (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 6.1 uM	Inhibition of TCPTP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	> 10 uM	Inhibition of LAR (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	> 10 uM	Inhibition of PTPalpha (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	= 21 uM	Inhibition of CDC14A (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444
IC50 (binding)	> 30 uM	Inhibition of Laforin (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis	ChEMBL.	23305444

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2316906

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1740993