Detailed information for compound 175544

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 674.793 | Formula: C25H42N10O8S2
  • H donors: 9 H acceptors: 8 LogP: -4.69 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)CC[C@@]1(CCN=C(N)N)NC(=O)[C@@H](CSSC(C)(C)C(NC(=O)[C@H](NC(=O)CNC1=O)CC(=O)O)C(=O)C)NC(=O)C
  • InChi: 1S/C25H42N10O8S2/c1-12(36)19-24(3,4)45-44-11-15(32-13(2)37)21(42)35-25(6-5-16(26)27,7-8-30-23(28)29)22(43)31-10-17(38)33-14(9-18(39)40)20(41)34-19/h14-15,19H,5-11H2,1-4H3,(H3,26,27)(H,31,43)(H,32,37)(H,33,38)(H,34,41)(H,35,42)(H,39,40)(H4,28,29,30)/t14-,15+,19?,25-/m0/s1
  • InChiKey: FFHUBOKWAHIRCD-HKTQHCCBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0083 0.0063 0.0063
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0312 0.1265 0.144
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0312 0.1265 0.2805
Loa Loa (eye worm) hypothetical protein 0.0375 0.1594 0.1594
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0274 0.1069 0.1069
Schistosoma mansoni protein kinase C mu 0.0192 0.0636 0.2115
Schistosoma mansoni nephrin 0.0204 0.0697 0.2325
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0343 0.143 1
Echinococcus granulosus cyclin dependent kinase 9 0.0084 0.007 0.0156
Brugia malayi P38 map kinase family protein 2 0.0297 0.1185 0.1185
Loa Loa (eye worm) melatonin receptor type 1A 0.0312 0.1265 0.1265
Schistosoma mansoni neuropeptide receptor 0.0312 0.1265 0.4286
Echinococcus granulosus serine:threonine protein kinase N2 0.0083 0.0063 0.014
Brugia malayi protein-tyrosine kinase 0.0155 0.0441 0.0441
Plasmodium falciparum protein serine/threonine kinase-1 0.0285 0.1124 1
Plasmodium falciparum protein kinase, putative 0.0086 0.0081 0.0361
Entamoeba histolytica protein kinase, putative 0.0233 0.0849 0.6806
Onchocerca volvulus 0.0312 0.1265 0.1224
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0182 0.0583 0.1291
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0285 0.1124 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Plasmodium vivax casein kinase 1, putative 0.0111 0.021 0.1221
Schistosoma mansoni neuropeptide F-like receptor 0.0312 0.1265 0.4286
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0111 0.021 0.021
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0233 0.0849 0.1882
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0297 0.1185 0.8235
Echinococcus granulosus neuropeptides capa receptor 0.0312 0.1265 0.2805
Brugia malayi Tachykinin-like peptides receptor 99D 0.0312 0.1265 0.1265
Plasmodium falciparum calcium-dependent protein kinase 3 0.011 0.0209 0.1543
Schistosoma mansoni protein kinase 0.0206 0.0708 0.2364
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0063 0.0155
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.0186
Giardia lamblia Kinase, NEK 0.0248 0.0931 0.6297
Onchocerca volvulus 0.0161 0.0472 0.0427
Trichomonas vaginalis STE family protein kinase 0.0343 0.143 1
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0169 0.0517 0.0588
Schistosoma mansoni protein kinase 0.0343 0.143 0.4853
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0209 0.1203
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Echinococcus multilocularis tyrosine protein kinase Srms 0.0155 0.0441 0.0502
Echinococcus multilocularis mitogen activated protein kinase 14 0.0297 0.1185 0.1348
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0152 0.0427 0.1394
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Onchocerca volvulus 0.0093 0.0118 0.0071
Trypanosoma cruzi cdc2-related kinase 1 0.0121 0.0266 0.1617
Echinococcus granulosus alpha 1A adrenergic receptor 0.0312 0.1265 0.2805
Echinococcus granulosus tyrosine protein kinase Src42A 0.0103 0.0171 0.0379
Trypanosoma brucei protein kinase, putative 0.0233 0.0849 0.5814
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0106 0.0186 0.104
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Schistosoma mansoni protein kinase 0.0413 0.1796 0.6118
Schistosoma mansoni amine GPCR 0.0312 0.1265 0.4286
Echinococcus multilocularis protein kinase c iota type 0.0115 0.0231 0.0263
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0292 0.116 0.116
Trypanosoma cruzi aurora B kinase, putative 0.0206 0.0708 0.4801
Brugia malayi ORL1-like opioid receptor 0.0312 0.1265 0.1265
Echinococcus granulosus raf serine:threonine protein kinase 0.0087 0.0085 0.0189
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Giardia lamblia Aurora kinase 0.0206 0.0708 0.4641
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0086 0.0081 0.0281
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0108 0.0196 0.0196
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0077 0.0033 0.0073
Plasmodium falciparum serine/threonine protein kinase, putative 0.0206 0.0708 0.6156
Echinococcus granulosus epidermal growth factor receptor 0.0179 0.0567 0.1256
Echinococcus multilocularis c src tyrosine kinase 0.012 0.0259 0.0295
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0384 0.1644 0.1644
Loa Loa (eye worm) AGC/PKN protein kinase 0.0083 0.0063 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0233 0.0849 0.5814
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0367 0.1556 0.1556
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0308 0.1245 0.8671
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0106 0.0186 0.104
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus multilocularis roundabout 2 0.0077 0.0033 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0234 0.073
Schistosoma mansoni vav2 0.0077 0.0035 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Loa Loa (eye worm) hypothetical protein 0.0221 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.016 0.0467 0.0467
Onchocerca volvulus 0.0233 0.0849 0.0805
Loa Loa (eye worm) hypothetical protein 0.016 0.0467 0.0467
Brugia malayi Protein kinase domain containing protein 0.0384 0.1644 0.1644
Schistosoma mansoni kinase 0.0076 0.0029 0.0022
Echinococcus multilocularis protein KINase family member (kin 25) 0.0189 0.0623 0.0709
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0413 0.1796 0.2044
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus neuroglian 0.0077 0.0033 0.0073
Trypanosoma brucei casein kinase I, isoform 2 0.0111 0.021 0.1214
Echinococcus multilocularis rho associated protein kinase 0.0338 0.1404 0.1598
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0344 0.1434 0.3178
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0042 0.0066
Schistosoma mansoni tyrosine kinase 0.012 0.0259 0.0816
Echinococcus granulosus 7TM GPCR rhodopsin 0.0312 0.1265 0.2805
Brugia malayi GnHR receptor homolog 0.0312 0.1265 0.1265
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0077 0.0033 0.0036
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0115 0.0234 0.1388
Loa Loa (eye worm) hypothetical protein 0.0115 0.0234 0.0234
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0343 0.143 0.143
Echinococcus granulosus peptide allatostatin:somatostatin 0.0312 0.1265 0.2805
Echinococcus granulosus g protein coupled receptor 0.0312 0.1265 0.2805
Echinococcus multilocularis g protein coupled receptor 0.0312 0.1265 0.144
Loa Loa (eye worm) hypothetical protein 0.0324 0.1328 0.1328
Echinococcus multilocularis roundabout 2 0.0077 0.0033 0.0037
Echinococcus multilocularis dual specificity 0.0308 0.1245 0.1417
Trichomonas vaginalis CK1 family protein kinase 0.0111 0.021 0.1214
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.1105 0.3734
Schistosoma mansoni rap gtpase-activating protein 0.0106 0.0186 0.0564
Brugia malayi G-protein coupled receptor 0.0312 0.1265 0.1265
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0312 0.1265 0.4286
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0182 0.0583 0.1291
Echinococcus granulosus tyrosine protein kinase shark 0.0093 0.0118 0.0261
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni cell adhesion molecule 0.0077 0.0033 0.0036
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0518 0.2344 0.2344
Onchocerca volvulus 0.0312 0.1265 0.1224
Giardia lamblia Kinase, CMGC GSK 0.0233 0.0849 0.5685
Brugia malayi neuropeptide F receptor 0.0312 0.1265 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0042 0.0066
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0206 0.0708 0.1569
Echinococcus multilocularis cyclin dependent kinase 0.0121 0.0266 0.0303
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0312 0.1265 0.144
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0179 0.0567 0.1256
Schistosoma mansoni tyrosine kinase 0.0377 0.1607 0.5466
Echinococcus multilocularis allatostatin A receptor 0.0312 0.1265 0.144
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.026 0.0991 0.2197
Loa Loa (eye worm) hypothetical protein 0.0254 0.0961 0.0961
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0063 0.014
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0233 0.0849 0.5814
Echinococcus multilocularis serine threonine protein kinase 0.0083 0.0063 0.0072
Plasmodium vivax protein kinase Crk2 0.0121 0.0266 0.1758
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0077 0.0033 0.0033
Echinococcus multilocularis insulin receptor 0.033 0.1359 0.1546
Echinococcus multilocularis somatostatin receptor 0.0312 0.1265 0.144
Schistosoma mansoni tyrosine kinase 0.0182 0.0583 0.1931
Brugia malayi SRC-1 0.0182 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni protein kinase 0.0344 0.1434 0.4867
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.011 0.0209 0.0209
Trichomonas vaginalis STE family protein kinase 0.0343 0.143 1
Echinococcus granulosus allatostatin A receptor 0.0312 0.1265 0.2805
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0192 0.0636 0.0636
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0182 0.0583 0.0663
Brugia malayi protein C17H12.11 0.0129 0.0305 0.0305
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0115 0.0234 0.1452
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0121 0.0266 0.0266
Onchocerca volvulus 0.0312 0.1265 0.1224
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0312 0.1265 0.4286
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0115 0.0234 0.1388
Echinococcus granulosus serotonin receptor 0.0312 0.1265 0.2805
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0281 0.1105 0.1105
Echinococcus granulosus casein kinase I alpha 0.0111 0.021 0.0466
Echinococcus granulosus rhodopsin orphan GPCR 0.0312 0.1265 0.2805
Trypanosoma cruzi casein kinase, delta isoform, putative 0.008 0.0047 0.0037
Echinococcus granulosus protein kinase C gamma type 0.0083 0.0063 0.014
Brugia malayi hypothetical protein 0.0628 0.2922 0.2922
Echinococcus granulosus g protein coupled receptor 0.0312 0.1265 0.2805
Brugia malayi Protein kinase domain containing protein 0.0093 0.0118 0.0118
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0371 0.1574 0.349
Echinococcus granulosus tyrosine protein kinase Fyn 0.0182 0.0583 0.1291
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0093 0.0118 0.0261
Echinococcus granulosus neuroglian 0.0196 0.0657 0.1456
Echinococcus granulosus cyclin dependent kinase 19 0.0307 0.1239 0.2747
Echinococcus granulosus fmrfamide receptor 0.0312 0.1265 0.2805
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0889 0.4294 0.4294
Brugia malayi C1-like domain containing protein 0.0192 0.0636 0.0636
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.0708 0.2364
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0312 0.1265 0.4286
Schistosoma mansoni tyrosine kinase 0.033 0.1359 0.4608
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0312 0.1265 0.1224
Echinococcus granulosus tyrosine kinase 0.0093 0.0118 0.0261
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni hypothetical protein 0.0312 0.1265 0.4286
Brugia malayi Protein kinase domain containing protein 0.0371 0.1574 0.1574
Echinococcus granulosus serine:threonine kinase SAD 1 0.0079 0.0042 0.0093
Echinococcus granulosus casein kinase i 0.0111 0.021 0.0466
Echinococcus multilocularis neuroglian 0.0077 0.0033 0.0037
Brugia malayi Fibronectin type III domain containing protein 0.016 0.0467 0.0467
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0206 0.0708 0.0806
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0234 0.073
Echinococcus granulosus defective proboscis extension response 0.0152 0.0427 0.0946
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0206 0.0709 0.0709
Echinococcus granulosus neuropeptide Y receptor 0.0312 0.1265 0.2805
Toxoplasma gondii AGC kinase 0.0115 0.0234 0.1779
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0312 0.1265 0.1265
Loa Loa (eye worm) AUR protein kinase 0.0206 0.0708 0.0708
Loa Loa (eye worm) TK/FAK protein kinase 0.0594 0.2743 0.2743
Onchocerca volvulus 0.0312 0.1265 0.1224
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0155 0.0441 0.0502
Echinococcus granulosus rhodopsin orphan GPCR 0.0312 0.1265 0.2805
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0371 0.1574 0.1574
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus insulin receptor 0.033 0.1359 0.3012
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0401 0.1731 0.3837
Brugia malayi Tyrosine-protein kinase abl-1 0.027 0.1043 0.1043
Echinococcus multilocularis dual specificity mitogen activated protein 0.0343 0.143 0.1627
Schistosoma mansoni amine GPCR 0.0312 0.1265 0.4286
Echinococcus granulosus neuropeptide s receptor 0.0312 0.1265 0.2805
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0206 0.0708 0.6003
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0076 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Schistosoma mansoni tyrosine kinase 0.0491 0.2206 0.7531
Echinococcus granulosus dual specificity protein kinase clk2 0.0285 0.1124 0.2492
Schistosoma mansoni serine/threonine protein kinase 0.0265 0.1018 0.3432
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0931 0.4511 1
Trypanosoma brucei aurora B kinase 0.0206 0.0708 0.4801
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.121 0.4097
Schistosoma mansoni biogenic amine receptor 0.0312 0.1265 0.4286
Schistosoma mansoni serine/threonine protein kinase 0.0367 0.1556 0.5288
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0708 0.4801
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0628 0.2922 0.6477
Entamoeba histolytica casein kinase 1, putative 0.0111 0.021 0.1664
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.0081 0.0622
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus titin 0.0083 0.0063 0.0139
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Brugia malayi SH2 domain containing protein 0.0093 0.0118 0.0118
Echinococcus granulosus rhodopsin orphan GPCR 0.0312 0.1265 0.2805
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0708 0.4801
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.011 0.0209 0.1543
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0312 0.1265 0.1265
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0206 0.0708 0.5673
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0115 0.0234 0.0519
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Trichomonas vaginalis AGC family protein kinase 0.0248 0.0931 0.6408
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0115 0.0234 0.1388
Brugia malayi Protein kinase domain containing protein 0.0121 0.0266 0.0266
Echinococcus granulosus mitogen activated protein kinase 14 0.0297 0.1185 0.2626
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0344 0.1434 0.1631
Brugia malayi hypothetical protein 0.0093 0.0118 0.0118
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0155 0.044 0.0501
Echinococcus multilocularis casein kinase I alpha 0.0111 0.021 0.0239
Loa Loa (eye worm) hypothetical protein 0.0134 0.0335 0.0335
Echinococcus multilocularis neuropeptide FF receptor 2 0.0312 0.1265 0.144
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0367 0.1556 0.1556
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0312 0.1265 0.2805
Loa Loa (eye worm) neuropeptide F receptor 0.0312 0.1265 0.1265
Entamoeba histolytica cell division protein kinase 2, putative 0.0121 0.0266 0.2115
Echinococcus multilocularis orexin receptor type 2 0.0312 0.1265 0.144
Echinococcus granulosus casein kinase I alpha 0.0111 0.021 0.0466
Echinococcus granulosus rho-associated protein kinase 1 0.0338 0.1404 0.3113
Loa Loa (eye worm) hypothetical protein 0.0129 0.0305 0.0305
Echinococcus multilocularis activin receptor type 0.0857 0.4125 0.4694
Echinococcus granulosus dual specificity mitogen activated protein 0.0343 0.143 0.3169
Echinococcus granulosus neuropeptides capa receptor 0.0312 0.1265 0.2805
Brugia malayi casein kinase 1, delta 0.0111 0.021 0.021
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0401 0.1731 0.1969
Brugia malayi serine/threonine protein kinase 6 0.0206 0.0708 0.0708
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.011 0.0209 0.1203
Brugia malayi cyclin-dependent kinase 7 homolog 0.0201 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.011 0.0209 0.1206
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0274 0.1069 0.1069
Brugia malayi neuropeptide F receptor 0.0312 0.1265 0.1265
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0233 0.0849 0.0849
Trichomonas vaginalis CK1 family protein kinase 0.0111 0.021 0.1214
Brugia malayi AKH receptor 0.0312 0.1265 0.1265
Echinococcus granulosus TGF-beta receptor type-1 0.0182 0.0585 0.1296
Brugia malayi serine/threonine-protein kinase PAK 7 0.0417 0.1816 0.1816
Brugia malayi p70 ribosomal S6 kinase beta 0.0083 0.0063 0.0063
Schistosoma mansoni vesicular amine transporter 0.0152 0.0427 0.1394
Trichomonas vaginalis STE family protein kinase 0.0343 0.143 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0084 0.0071 0.0157
Echinococcus multilocularis g protein coupled receptor 0.0312 0.1265 0.144
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.011 0.0209 0.1543
Schistosoma mansoni protein kinase 0.0264 0.1012 0.3414
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.011 0.0209 0.0209
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0343 0.143 1
Echinococcus granulosus cyclin dependent kinase 1 0.0121 0.0266 0.059
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0708 0.4801
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0129 0.0305 0.0305
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Brugia malayi SH2 domain containing protein 0.0093 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Giardia lamblia Kinase, NEK 0.0248 0.0931 0.6297
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0371 0.1574 0.1791
Schistosoma mansoni adenoreceptor 0.0312 0.1265 0.4286
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0312 0.1265 0.1265
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0266 0.1617
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0413 0.1796 0.3982
Brugia malayi Dopamine receptor protein 1 0.0312 0.1265 0.1265
Plasmodium falciparum NIMA related kinase 1 0.0248 0.0931 0.8217
Onchocerca volvulus 0.0312 0.1265 0.1224
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0628 0.2922 0.3324
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.1124 0.3799
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0312 0.1265 0.1265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Schistosoma mansoni protein kinase 0.0182 0.0585 0.1939
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0192 0.0636 0.0636
Loa Loa (eye worm) TK/ALK protein kinase 0.1428 0.7116 0.7116
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0312 0.1265 0.1265
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.012 0.0259 0.0816
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Leishmania major protein kinase A catalytic subunit isoform 2 0.0115 0.0234 0.1388
Brugia malayi Protein kinase domain containing protein 0.0093 0.0118 0.0118
Echinococcus granulosus calcium dependent protein kinase 0.0079 0.0045 0.0101
Echinococcus granulosus 7tm_1 domain containing protein 0.0312 0.1265 0.2805
Giardia lamblia Kinase, CMGC CDK 0.0121 0.0266 0.1359
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.026 0.0991 0.0991
Schistosoma mansoni tyrosine kinase 0.0587 0.2709 0.9268
Onchocerca volvulus 0.0657 0.3074 0.3042
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.021 0.0647
Entamoeba histolytica protein kinase, putative 0.009 0.0101 0.0786
Loa Loa (eye worm) TYRA-2 protein 0.0312 0.1265 0.1265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Onchocerca volvulus 0.0093 0.0118 0.0071
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.011 0.0209 0.0463
Schistosoma mansoni protein kinase 0.0371 0.1574 0.5352
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0312 0.1265 0.144
Onchocerca volvulus 0.0083 0.0063 0.0016
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0248 0.0931 0.8146
Onchocerca volvulus 0.0106 0.0186 0.014
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0152 0.0427 0.1394
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.1124 0.3799
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0274 0.1069 0.1069
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.1404 0.4766
Loa Loa (eye worm) hypothetical protein 0.0093 0.0118 0.0118
Giardia lamblia Kinase, AGC PKA 0.0115 0.0234 0.1123
Loa Loa (eye worm) hypothetical protein 0.0349 0.1461 0.1461
Loa Loa (eye worm) TK protein kinase 0.0117 0.0241 0.0241
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0518 0.2344 0.2668
Leishmania major protein kinase, putative 0.011 0.0209 0.1203
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0206 0.0708 0.5673
Brugia malayi larval opioid receptor 0.0312 0.1265 0.1265
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0312 0.1265 0.144
Loa Loa (eye worm) TK protein kinase 0.0307 0.1241 0.1241
Echinococcus multilocularis tyrosine protein kinase Blk 0.0155 0.0441 0.0502
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0233 0.0849 0.5814
Giardia lamblia Kinase, CMGC GSK 0.0233 0.0849 0.5685
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0083 0.0063 0.014
Entamoeba histolytica protein kinase domain containing protein 0.0308 0.1245 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0117 0.0241 0.0274
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0155 0.0441 0.0979
Echinococcus granulosus Protein kinase C brain isozyme 0.0115 0.0231 0.0512
Echinococcus granulosus g protein coupled receptor 0.0312 0.1265 0.2805
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0384 0.1643 0.187
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0099 0.0147 0.0327
Schistosoma mansoni hypothetical protein 0.0312 0.1265 0.4286
Schistosoma mansoni hypothetical protein 0.0312 0.1265 0.4286
Loa Loa (eye worm) hypothetical protein 0.0151 0.0421 0.0421
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0115 0.0234 0.0267
Echinococcus multilocularis raf serine:threonine protein kinase 0.0087 0.0085 0.0097
Loa Loa (eye worm) hypothetical protein 0.0292 0.116 0.116
Echinococcus multilocularis tyrosine kinase 0.0093 0.0118 0.0134
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.011 0.0209 0.1206
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus g-protein coupled receptor 0.0312 0.1265 0.2805
Trichomonas vaginalis AGC family protein kinase 0.0091 0.0105 0.0454
Echinococcus multilocularis cyclin dependent kinase 9 0.0076 0.0029 0.0033
Echinococcus granulosus somatostatin receptor 0.0312 0.1265 0.2805
Echinococcus granulosus Vam6:Vps39 protein 0.0106 0.0186 0.0413
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0103 0.0171 0.0194
Loa Loa (eye worm) AGC/NDR protein kinase 0.0083 0.0063 0.0063
Echinococcus granulosus mitogen activated protein kinase 11 0.0297 0.1185 0.2626
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0083 0.0063 0.0063
Brugia malayi Stress-activated protein kinase jnk-1 0.0518 0.2344 0.2344
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus cyclin dependent kinase 5 0.0121 0.0266 0.059
Echinococcus multilocularis cyclin dependent kinase 9 0.0084 0.007 0.008
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0083 0.0063 0.0063
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0285 0.1124 0.7799
Trichomonas vaginalis CMGC family protein kinase 0.0233 0.0849 0.5814
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus tyrosine protein kinase ABL1 0.053 0.2406 0.5334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0063 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0234 0.073
Entamoeba histolytica protein kinase , putative 0.0206 0.0708 0.5673
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0099 0.0147 0.0168
Echinococcus granulosus hypothetical protein 0.0312 0.1265 0.2805
Echinococcus granulosus aurora kinase A 0.0206 0.0708 0.1569
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0084 0.0071 0.0081
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0086 0.0081 0.0281
Loa Loa (eye worm) hypothetical protein 0.0152 0.0427 0.0427
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0083 0.0063 0.0072
Echinococcus multilocularis tyrosine protein kinase shark 0.0093 0.0118 0.0134
Echinococcus multilocularis neuropeptide receptor A26 0.0312 0.1265 0.144
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0182 0.0585 0.0665
Echinococcus granulosus neuropeptide receptor A26 0.0312 0.1265 0.2805
Onchocerca volvulus 0.0312 0.1265 0.1224
Loa Loa (eye worm) hypothetical protein 0.0233 0.0849 0.0849
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0302 0.121 0.121
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.011 0.0209 0.0463
Schistosoma mansoni opsin-like receptor 0.0312 0.1265 0.4286
Trypanosoma cruzi cdc2-related kinase 3 0.0121 0.0266 0.1617
Giardia lamblia Kinase, CMGC CLK 0.0285 0.1124 0.7731
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0285 0.1124 0.1124
Schistosoma mansoni protein kinase 0.0344 0.1434 0.4867
Echinococcus granulosus neuropeptide Y receptor 0.0312 0.1265 0.2805
Echinococcus granulosus activated cdc42 kinase 1 0.0404 0.1749 0.3878
Schistosoma mansoni amine GPCR 0.0312 0.1265 0.4286
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0266 0.084
Brugia malayi putative neuropeptide receptor NPR1 0.0312 0.1265 0.1265
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0285 0.1124 0.7799
Schistosoma mansoni biogenic amine (5HT) receptor 0.0312 0.1265 0.4286
Echinococcus multilocularis casein kinase I alpha 0.0111 0.021 0.0239
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0308 0.1245 0.8671
Schistosoma mansoni tyrosine kinase 0.0124 0.0278 0.0883
Brugia malayi Protein kinase domain containing protein 0.1428 0.7118 0.7118
Schistosoma mansoni growth hormone secretagogue receptor 0.0312 0.1265 0.4286
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0042 0.0066
Echinococcus multilocularis Immunoglobulin 0.0152 0.0427 0.0485
Leishmania major casein kinase, putative 0.0111 0.021 0.1214
Brugia malayi serine/threonine kinase 12 0.0206 0.0708 0.0708
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0297 0.1185 0.1185
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0077 0.0033 0.0037
Brugia malayi bone morphogenetic protein type 1 receptor 0.0206 0.0709 0.0709
Onchocerca volvulus 0.0312 0.1265 0.1224
Brugia malayi Protein kinase domain containing protein 0.0206 0.0709 0.0709
Echinococcus multilocularis casein kinase i 0.0111 0.021 0.0239
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0312 0.1265 0.144
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0343 0.143 1
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Brugia malayi Protein kinase domain containing protein 0.0285 0.1124 0.1124
Schistosoma mansoni titin 0.0083 0.0063 0.0138
Echinococcus granulosus sex peptide receptor 0.0312 0.1265 0.2805
Loa Loa (eye worm) AGC/PKA protein kinase 0.0115 0.0234 0.0234
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0182 0.0583 0.0663
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0063 0.014
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.011 0.0209 0.0237
Loa Loa (eye worm) neuropeptide F receptor 0.0312 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0161 0.0472 0.0472
Echinococcus multilocularis mitogen activated protein kinase 11 0.0297 0.1185 0.1348
Echinococcus multilocularis titin 0.0083 0.0063 0.0071
Leishmania major protein kinase A catalytic subunit isoform 1 0.0115 0.0234 0.1388
Giardia lamblia Kinase, CMGC CDK 0.0121 0.0266 0.1359
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0285 0.1124 0.7799
Echinococcus multilocularis neuropeptide Y receptor 0.0312 0.1265 0.144
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0297 0.1185 0.8235
Echinococcus granulosus dual specificity 0.0308 0.1245 0.276
Onchocerca volvulus 0.0093 0.0118 0.0071
Echinococcus granulosus fibroblast growth factor receptor 4 0.0264 0.1011 0.2242
Plasmodium falciparum protein kinase 5 0.0121 0.0266 0.2074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Echinococcus multilocularis serotonin receptor 0.0312 0.1265 0.144
Echinococcus multilocularis protein tyrosine kinase 0.0587 0.2709 0.3083
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0231 0.0719
Leishmania major protein kinase, putative 0.0285 0.1124 0.7799
Brugia malayi Immunoglobulin I-set domain containing protein 0.0307 0.1241 0.1241
Schistosoma mansoni serine/threonine protein kinase 0.0384 0.1644 0.5593
Loa Loa (eye worm) TK/EGFR protein kinase 0.0179 0.0567 0.0567
Echinococcus granulosus activin receptor type 0.0857 0.4125 0.9145
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0312 0.1265 0.144
Entamoeba histolytica serine/threonine protein kinase, putative 0.0079 0.0042 0.0307
Echinococcus granulosus contactin 0.0077 0.0033 0.0073
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0106 0.0186 0.0212
Toxoplasma gondii casein kinase I 0.0111 0.021 0.1557
Trypanosoma cruzi casein kinase, putative 0.0111 0.021 0.1214
Giardia lamblia Kinase, STE STE20 0.0343 0.143 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0312 0.1265 0.4286
Echinococcus multilocularis mitogen activated protein kinase 14 0.0297 0.1185 0.1348
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0182 0.0583 0.0663
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0029 0.0022
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0281 0.1105 0.1257
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0274 0.1069 0.2369
Loa Loa (eye worm) hypothetical protein 0.0221 0.079 0.079
Trypanosoma cruzi casein kinase, putative 0.0111 0.021 0.1214
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0312 0.1265 0.2805
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0077 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0077 0.0033 0.0033
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0111 0.021 0.1214
Entamoeba histolytica PH domain containing protein kinase, putative 0.0123 0.0272 0.2164
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0312 0.1265 0.1265
Echinococcus granulosus protein kinase shaggy 0.0233 0.0849 0.1881
Trypanosoma cruzi casein kinase, putative 0.0111 0.021 0.1214
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0312 0.1265 0.144
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.011 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Toxoplasma gondii AGC kinase 0.0083 0.0063 0.0199
Schistosoma mansoni tyrosine kinase 0.0093 0.0118 0.0329
Echinococcus multilocularis tyrosine protein kinase ABL1 0.053 0.2406 0.2738
Schistosoma mansoni opsin-like receptor 0.0312 0.1265 0.4286
Echinococcus multilocularis roundabout 2 0.0229 0.083 0.0945
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.011 0.0209 0.0237
Brugia malayi Protein kinase domain containing protein 0.0083 0.0063 0.0063
Brugia malayi hypothetical protein 0.0106 0.0186 0.0186
Echinococcus granulosus neuropeptide receptor 0.0312 0.1265 0.2805
Brugia malayi protein unc-22 0.0083 0.0063 0.0063
Echinococcus multilocularis epidermal growth factor receptor 0.0179 0.0567 0.0645
Schistosoma mansoni opsin-like receptor 0.0312 0.1265 0.4286
Schistosoma mansoni tyrosine kinase 0.0124 0.0278 0.0883
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0266 0.1617
Brugia malayi Serine/threonine-protein kinase SULU 0.0628 0.2922 0.2922
Entamoeba histolytica protein kinase, putative 0.0117 0.0241 0.1912
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0106 0.0186 0.0564
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.016 0.0468 0.0468
Schistosoma mansoni neuropeptide receptor 0.0312 0.1265 0.4286
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0206 0.0708 0.5673
Brugia malayi cell division control protein 2 homolog 0.0121 0.0266 0.0266
Echinococcus multilocularis tyrosine protein kinase Abl 0.0287 0.1134 0.129
Echinococcus granulosus twitchin 0.0227 0.082 0.1818
Echinococcus multilocularis cyclin dependent kinase 5 0.0121 0.0266 0.0303
Schistosoma mansoni biogenic amine receptor 0.0312 0.1265 0.4286
Echinococcus granulosus tachykinin peptides receptor 99D 0.0312 0.1265 0.2805
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Brugia malayi Protein kinase domain containing protein 0.0093 0.0118 0.0118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Brugia malayi sulfakinin receptor protein 0.0312 0.1265 0.1265
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0115 0.0234 0.0267
Schistosoma mansoni neuropeptide receptor 0.0312 0.1265 0.4286
Onchocerca volvulus 0.1978 1 1
Echinococcus granulosus titin 0.0083 0.0063 0.0139
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0312 0.1265 0.4286
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0063 0.014
Brugia malayi Protein kinase domain containing protein 0.016 0.0468 0.0468
Loa Loa (eye worm) IKK protein kinase 0.1978 1 1
Onchocerca volvulus 0.0312 0.1265 0.1224
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Loa Loa (eye worm) hypothetical protein 0.0168 0.051 0.051
Entamoeba histolytica protein kinase domain containing protein 0.0206 0.0708 0.5673
Schistosoma mansoni tyrosine kinase 0.0124 0.0278 0.0883
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0182 0.0583 0.0663
Schistosoma mansoni tyrosine kinase 0.012 0.0259 0.0816
Entamoeba histolytica protein kinase, putative 0.009 0.0101 0.0786
Echinococcus granulosus biogenic amine 5HT receptor 0.0312 0.1265 0.2805
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0086 0.0081 0.0361
Trypanosoma cruzi cdc2-related kinase 1 0.0121 0.0266 0.1617
Loa Loa (eye worm) hypothetical protein 0.0277 0.1082 0.1082
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0308 0.1245 0.1245
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0231 0.0719
Onchocerca volvulus 0.0312 0.1265 0.1224
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0077 0.0033 0.0037
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0312 0.1265 0.1265
Leishmania major protein kinase A catalytic subunit 0.0115 0.0234 0.1388
Schistosoma mansoni biogenic amine (5HT) receptor 0.0312 0.1265 0.4286
Plasmodium vivax serine/threonine kinase-1, putative 0.0285 0.1124 1
Trypanosoma cruzi cdc2-related kinase 3 0.0121 0.0266 0.1617
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Onchocerca volvulus Tyrosine kinase homolog 0.0756 0.3592 0.3562
Schistosoma mansoni serine/threonine protein kinase 0.0518 0.2344 0.8009
Plasmodium falciparum glycogen synthase kinase 3 0.0233 0.0849 0.7455
Echinococcus multilocularis twitchin 0.0075 0.0023 0.0026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0063 0.0063
Loa Loa (eye worm) TK/ROR protein kinase 0.0099 0.0147 0.0147
Loa Loa (eye worm) CAMK/PKD protein kinase 0.016 0.0468 0.0468
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0312 0.1265 0.144
Brugia malayi probable protein kinase 0.0264 0.1012 0.1012
Loa Loa (eye worm) AUR protein kinase 0.0206 0.0708 0.0708
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0083 0.0063 0.0072
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0337 0.1398 0.31
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus multilocularis cyclin dependent kinase 1 0.0121 0.0266 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0312 0.1265 0.2805
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0033 0.0033
Brugia malayi Melatonin receptor type 1A 0.0312 0.1265 0.1265
Echinococcus multilocularis epidermal growth factor receptor 0.0179 0.0567 0.0645
Schistosoma mansoni protein kinase 0.0413 0.1796 0.6118
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Brugia malayi follicle stimulating hormone receptor 0.0312 0.1265 0.1265
Brugia malayi Protein kinase domain containing protein 0.0093 0.0118 0.0118
Loa Loa (eye worm) AGC/PKA protein kinase 0.0115 0.0234 0.0234
Plasmodium falciparum calcium-dependent protein kinase 5 0.011 0.0209 0.1543
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0312 0.1265 0.4286
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0367 0.1556 0.1516
Trypanosoma brucei cdc2-related kinase 1 0.0121 0.0266 0.1617
Schistosoma mansoni protein kinase 0.0344 0.1434 0.4867
Echinococcus granulosus Immunoglobulin 0.0152 0.0427 0.0946
Loa Loa (eye worm) TK/INSR protein kinase 0.033 0.1359 0.1359
Loa Loa (eye worm) hypothetical protein 0.0404 0.1749 0.1749
Toxoplasma gondii AGC kinase 0.0115 0.0234 0.1779
Plasmodium vivax glycogen synthase kinase 3, putative 0.0233 0.0849 0.7354
Echinococcus multilocularis serine:threonine protein kinase N2 0.0083 0.0063 0.0072
Echinococcus granulosus tyrosine protein kinase Src42A 0.0182 0.0583 0.1291
Entamoeba histolytica protein kinase, putative 0.011 0.0209 0.1652
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0292 0.116 0.116
Schistosoma mansoni biogenic amine receptor 0.0312 0.1265 0.4286
Schistosoma mansoni cell adhesion molecule 0.0077 0.0033 0.0036
Echinococcus granulosus roundabout 2 0.0077 0.0033 0.0073
Echinococcus multilocularis G protein coupled receptor 139 0.0312 0.1265 0.144
Loa Loa (eye worm) SRC-1 0.0182 0.0583 0.0583
Echinococcus granulosus casein kinase I delta 0.0111 0.021 0.0466
Schistosoma mansoni cell adhesion molecule 0.0185 0.06 0.1993
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Onchocerca volvulus 0.0312 0.1265 0.1224
Schistosoma mansoni histamine h1 receptor 0.0312 0.1265 0.4286
Onchocerca volvulus 0.0312 0.1265 0.1224
Entamoeba histolytica protein kinase, putative 0.0206 0.0708 0.5673
Brugia malayi Protein kinase domain containing protein 0.0367 0.1556 0.1556
Brugia malayi Serotonin receptor 0.0312 0.1265 0.1265
Echinococcus multilocularis 0.0158 0.0456 0.0518
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0343 0.143 0.143
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0297 0.1185 0.8235
Onchocerca volvulus 0.0129 0.0305 0.0259
Loa Loa (eye worm) TK protein kinase 0.0155 0.0441 0.0441
Onchocerca volvulus 0.0312 0.1265 0.1224
Loa Loa (eye worm) hypothetical protein 0.1313 0.6515 0.6515
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0312 0.1265 0.1265
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0308 0.1245 0.8671
Brugia malayi casein kinase I 0.0111 0.021 0.021
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0285 0.1124 0.7799
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0182 0.0583 0.0663
Loa Loa (eye worm) G-protein coupled receptor 0.0312 0.1265 0.1265
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0137 0.0349 0.0398
Loa Loa (eye worm) TK/ABL protein kinase 0.053 0.2406 0.2406
Echinococcus granulosus tyrosine protein kinase Fyn 0.0182 0.0583 0.1291
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0312 0.1265 0.4286
Schistosoma mansoni tyrosine kinase 0.0264 0.1011 0.341
Echinococcus multilocularis Immunoglobulin 0.0152 0.0427 0.0485
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0312 0.1265 0.2805
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0115 0.0234 0.1779
Onchocerca volvulus 0.0292 0.116 0.1119
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0115 0.0234 0.1388
Trichomonas vaginalis STE family protein kinase 0.0248 0.0931 0.6408
Onchocerca volvulus 0.0307 0.1241 0.12
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0384 0.1643 0.3643
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0079 0.0042 0.0042
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Echinococcus granulosus tyrosine protein kinase HCK 0.0117 0.0241 0.0534
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0367 0.1556 0.1556
Entamoeba histolytica protein kinase, putative 0.0308 0.1245 1
Onchocerca volvulus 0.0312 0.1265 0.1224
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Brugia malayi serine/threonine-protein kinase 6 0.0206 0.0708 0.0708
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0155 0.0441 0.0978
Plasmodium falciparum calcium-dependent protein kinase 4 0.011 0.0209 0.1543
Echinococcus granulosus rhodopsin orphan GPCR 0.0312 0.1265 0.2805
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0312 0.1265 0.144
Echinococcus granulosus tyrosine protein kinase Blk 0.0155 0.0441 0.0979
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus rhodopsin orphan GPCR 0.0312 0.1265 0.2805
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0312 0.1265 0.144
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0115 0.0234 0.0234
Brugia malayi Protein kinase domain containing protein 0.0987 0.4807 0.4807
Echinococcus multilocularis casein kinase I alpha 0.0111 0.021 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.0642 0.2136
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0285 0.1124 0.7799
Echinococcus multilocularis protein kinase c epsilon type 0.0115 0.0231 0.0263
Schistosoma mansoni tyrosine kinase 0.0124 0.0281 0.0892
Entamoeba histolytica protein kinase, putative 0.0083 0.0063 0.0481
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0517 0.1706
Brugia malayi G-protein coupled receptor 0.0312 0.1265 0.1265
Echinococcus multilocularis neuropeptide receptor 0.0312 0.1265 0.144
Schistosoma mansoni neuroglian 0.0077 0.0033 0.0036
Schistosoma mansoni protein kinase 0.0158 0.0456 0.1494
Echinococcus granulosus neuropeptide FF receptor 2 0.0312 0.1265 0.2805
Echinococcus granulosus NDR protein kinase 0.0083 0.0063 0.014
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.011 0.0209 0.0237
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0987 0.4807 0.4807
Echinococcus granulosus rhodopsin orphan GPCR 0.0312 0.1265 0.2805
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0312 0.1265 0.144
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0176 0.0176
Entamoeba histolytica cell division protein kinase 2, putative 0.0129 0.0308 0.2449
Echinococcus multilocularis g protein coupled receptor 0.0312 0.1265 0.144
Schistosoma mansoni tyrosine kinase 0.0088 0.0091 0.0234
Echinococcus granulosus tyrosine kinase 0.0155 0.0441 0.0979
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.0186
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0121 0.0266 0.059
Echinococcus multilocularis fmrfamide receptor 0.0312 0.1265 0.144
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0302 0.121 0.121
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0367 0.1556 0.3449
Echinococcus multilocularis neuropeptide Y receptor 0.0312 0.1265 0.144
Brugia malayi Hr1 repeat family protein 0.0083 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus tyrosine protein kinase Src64B 0.0182 0.0583 0.1291
Plasmodium falciparum casein kinase 1 0.0111 0.021 0.1557
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0233 0.0849 0.2849
Schistosoma mansoni protein kinase 0.0086 0.0081 0.0201
Schistosoma mansoni vam6/vps39 related 0.0106 0.0186 0.0564
Echinococcus multilocularis casein kinase I delta 0.0111 0.021 0.0239
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0417 0.1816 0.1816
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Leishmania major protein kinase, putative 0.0206 0.0708 0.4801
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0182 0.0583 0.0663
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0312 0.1265 0.4286
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0215 0.0759 0.5165
Echinococcus multilocularis serotonin receptor 0.0312 0.1265 0.144
Brugia malayi intracellular kinase 0.0233 0.0849 0.0849
Echinococcus multilocularis calcium dependent protein kinase 0.0079 0.0045 0.0052
Echinococcus granulosus protein kinase c iota type 0.0115 0.0231 0.0512
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0121 0.0266 0.1617
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Onchocerca volvulus 0.0312 0.1265 0.1224
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0086 0.0081 0.0281
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0033 0.0033
Schistosoma mansoni alpha-1 adrenergic receptor 0.0312 0.1265 0.4286
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0264 0.1011 0.1151
Schistosoma mansoni protein kinase 0.0206 0.0709 0.2369
Onchocerca volvulus 0.0312 0.1265 0.1224
Brugia malayi Protein kinase domain containing protein 0.0307 0.1239 0.1239
Echinococcus granulosus biogenic amine 5HT receptor 0.0312 0.1265 0.2805
Schistosoma mansoni serine/threonine protein kinase 0.0307 0.1239 0.4197
Schistosoma mansoni myosin xvIII 0.0312 0.1265 0.4286
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0093 0.0118 0.0921
Echinococcus granulosus tm gpcr rhodopsin 0.0312 0.1265 0.2805
Brugia malayi Protein kinase domain containing protein 0.0083 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Loa Loa (eye worm) CAMK protein kinase 0.0083 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Echinococcus multilocularis serine:threonine protein kinase 38 0.0083 0.0063 0.0072
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0234 0.0854 0.0854
Onchocerca volvulus 0.0312 0.1265 0.1224
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0628 0.2922 0.2922
Loa Loa (eye worm) hypothetical protein 0.0189 0.0623 0.0623
Schistosoma mansoni serine/threonine kinase 0.0083 0.0063 0.014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0312 0.1265 0.144
Echinococcus granulosus tm gpcr rhodopsin 0.0312 0.1265 0.2805
Trichomonas vaginalis CK1 family protein kinase 0.0111 0.021 0.1214
Onchocerca volvulus 0.0168 0.051 0.0466
Brugia malayi Immunoglobulin I-set domain containing protein 0.016 0.0467 0.0467
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0232 0.0721
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Trypanosoma cruzi casein kinase, putative 0.0111 0.021 0.1214
Brugia malayi Serotonin receptor 0.0312 0.1265 0.1265
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.0029 0.0204
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0312 0.1265 0.4286
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0121 0.0266 0.1617
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0115 0.0234 0.0267
Echinococcus granulosus roundabout 2 0.0229 0.083 0.1841
Trypanosoma brucei protein kinase, putative 0.0086 0.0081 0.0281
Echinococcus multilocularis 0.0254 0.0961 0.1093
Toxoplasma gondii aurora kinase 0.0206 0.0708 0.6156
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0266 0.084
Schistosoma mansoni neuropeptide f receptor 76f 0.0312 0.1265 0.4286
Echinococcus granulosus tyrosine protein kinase Lyn 0.0213 0.0746 0.1654
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.0642 0.2136
Entamoeba histolytica protein kinase, putative 0.0206 0.0708 0.5673
Brugia malayi Protein kinase domain containing protein 0.0404 0.1749 0.1749
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0337 0.1398 0.1591
Brugia malayi G protein-coupled receptor 0.0312 0.1265 0.1265
Echinococcus multilocularis dro:myosuppressin receptor 0.0312 0.1265 0.144
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0233 0.0849 0.0849
Giardia lamblia Kinase, CK1 Casein kinase 0.0111 0.021 0.0944
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus casein kinase I alpha 0.0111 0.021 0.0466
Schistosoma mansoni tyrosine kinase 0.0179 0.0567 0.1876
Echinococcus multilocularis neuropeptide receptor 0.0312 0.1265 0.144
Schistosoma mansoni tyrosine kinase 0.033 0.1359 0.4608
Echinococcus granulosus activated cdc42 kinase 1 0.0404 0.1749 0.3878
Echinococcus granulosus protein tyrosine kinase 0.0587 0.2709 0.6007
Echinococcus granulosus cyclin dependent kinase 9 0.0076 0.0029 0.0064
Brugia malayi Temporarily assigned gene name protein 59 0.0106 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0106 0.0186 0.0564
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0121 0.0266 0.0266
Echinococcus multilocularis mitogen activated protein kinase 11 0.0297 0.1185 0.1348
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Onchocerca volvulus 0.0093 0.0118 0.0071
Echinococcus multilocularis death associated protein kinase 1 0.1747 0.8789 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0104 0.0176 0.0176
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0264 0.1011 0.2242
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.011 0.0209 0.0463
Schistosoma mansoni protein kinase 0.0111 0.021 0.0647
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0115 0.0231 0.0263
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0281 0.1105 0.1105
Onchocerca volvulus 0.0093 0.0118 0.0071
Echinococcus multilocularis neuropeptide s receptor 0.0312 0.1265 0.144
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0312 0.1265 0.4286
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus tm gpcr rhodopsin 0.0312 0.1265 0.2805
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0155 0.044 0.044
Schistosoma mansoni tyrosine kinase 0.0189 0.0623 0.207
Loa Loa (eye worm) hypothetical protein 0.0153 0.0431 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0085 0.0216
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0106 0.0186 0.0564
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0121 0.0266 0.2074
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0152 0.0427 0.0485
Schistosoma mansoni neuropeptide receptor 0.0312 0.1265 0.4286
Echinococcus granulosus hypothetical protein 0.0254 0.0961 0.213
Loa Loa (eye worm) hypothetical protein 0.011 0.0209 0.0209
Brugia malayi protein kinase C II. 0.0115 0.0231 0.0231
Onchocerca volvulus 0.0111 0.021 0.0164
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0115 0.0234 0.0267
Echinococcus granulosus dro:myosuppressin receptor 0.0312 0.1265 0.2805
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0312 0.1265 0.2805
Trypanosoma brucei cdc2-related kinase 3 0.0121 0.0266 0.1617
Trypanosoma brucei rac serine-threonine kinase, putative 0.009 0.0101 0.0429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0115 0.0234 0.1779
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0093 0.0118 0.0134
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0182 0.0583 0.0663
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni tyrosine kinase 0.0179 0.0567 0.1876
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0083 0.0063 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Echinococcus granulosus casein kinase I delta 0.0111 0.021 0.0466
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0193 0.0642 0.0642
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0233 0.0849 0.0966
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.016 0.0468 0.0468
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0079 0.0042 0.0047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0182 0.0583 0.0663
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Brugia malayi hypothetical protein 0.0129 0.0305 0.0305
Entamoeba histolytica protein kinase, putative 0.011 0.0209 0.1652
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0517 0.1706
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0158 0.0456 0.0456
Echinococcus granulosus cyclin dependent kinase 0.0121 0.0266 0.059
Schistosoma mansoni serine/threonine protein kinase 0.0628 0.2922 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0189 0.0623 0.138
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.026 0.0991 0.1128
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0111 0.021 0.021
Giardia lamblia Kinase, AGC AKT 0.0208 0.0721 0.4735
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0233 0.0849 0.1881
Loa Loa (eye worm) hypothetical protein 0.0277 0.1082 0.1082
Echinococcus multilocularis fmrfamide receptor 0.0312 0.1265 0.144
Giardia lamblia Kinase, NEK 0.0248 0.0931 0.6297
Loa Loa (eye worm) hypothetical protein 0.0134 0.0335 0.0335
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0111 0.021 0.021
Brugia malayi Protein kinase domain containing protein 0.033 0.1359 0.1359
Entamoeba histolytica protein kinase, putative 0.0308 0.1245 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0182 0.0583 0.1291
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Plasmodium vivax calcium-dependent protein kinase, putative 0.011 0.0209 0.1206
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0312 0.1265 0.4286
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0169 0.0517 0.1146
Brugia malayi putative serine/threonine kinase SADA gamma 0.0079 0.0042 0.0042
Schistosoma mansoni tyrosine kinase 0.0179 0.0567 0.1876
Brugia malayi Tyrosine-protein kinase abl-1 0.0287 0.1134 0.1134
Echinococcus granulosus epidermal growth factor receptor 0.0179 0.0567 0.1256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0312 0.1265 0.4286
Brugia malayi RE15519p 0.0312 0.1265 0.1265
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0308 0.1245 0.8671
Loa Loa (eye worm) hypothetical protein 0.0178 0.056 0.056
Brugia malayi hypothetical protein 0.016 0.0467 0.0467
Echinococcus multilocularis neuropeptides capa receptor 0.0312 0.1265 0.144
Loa Loa (eye worm) hypothetical protein 0.009 0.0103 0.0103
Echinococcus granulosus c src tyrosine kinase 0.012 0.0259 0.0574
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0208 0.0721 0.0721
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0233 0.0849 0.7455
Schistosoma mansoni amine GPCR 0.0312 0.1265 0.4286
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0209 0.0642
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0266 0.1617
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0115 0.0234 0.1388
Trichomonas vaginalis CMGC family protein kinase 0.0285 0.1124 0.7799
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0077 0.0033 0.0037
Brugia malayi hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.0308 0.1245 0.4217
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0248 0.0931 0.8217
Trypanosoma cruzi casein kinase, putative 0.0111 0.021 0.1214
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0312 0.1265 0.1265
Echinococcus multilocularis cyclin dependent kinase 1 0.0121 0.0266 0.0303
Brugia malayi putative neuropeptide receptor 0.0312 0.1265 0.1265
Brugia malayi Dopamine receptor protein 2 0.0312 0.1265 0.1265
Entamoeba histolytica PH domain containing protein kinase, putative 0.0123 0.0272 0.2164
Echinococcus multilocularis transfer RNA-Thr 0.0404 0.1749 0.199
Entamoeba histolytica casein kinase, putative 0.0111 0.021 0.1664
Brugia malayi Dopamine receptor 0.0312 0.1265 0.1265
Echinococcus multilocularis sex peptide receptor 0.0312 0.1265 0.144
Leishmania major protein kinase, putative 0.0285 0.1124 0.7799
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0083 0.0063 0.014
Echinococcus multilocularis G-protein coupled receptor, putative 0.0312 0.1265 0.144
Echinococcus multilocularis protein kinase shaggy 0.0233 0.0849 0.0966
Onchocerca volvulus 0.0093 0.0118 0.0071
Loa Loa (eye worm) hypothetical protein 0.0129 0.0305 0.0305
Schistosoma mansoni atypical protein kinase C 0.0115 0.0231 0.0719
Brugia malayi Protein kinase domain containing protein 0.009 0.0101 0.0101
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0033 0.0033
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0312 0.1265 0.144
Echinococcus granulosus tyrosine protein kinase Srms 0.0093 0.0118 0.0261
Schistosoma mansoni nephrin 0.0077 0.0033 0.0036
Plasmodium falciparum calcium-dependent protein kinase 2 0.011 0.0209 0.1543
Brugia malayi Cam kinase protein 1 0.011 0.0209 0.0209
Echinococcus granulosus TGF beta receptor type 1 0.0182 0.0585 0.1296
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0115 0.0234 0.1388
Echinococcus multilocularis neuropeptides capa receptor 0.0312 0.1265 0.144
Loa Loa (eye worm) gastrulation defective protein 1 0.0276 0.1076 0.1076
Leishmania major protein kinase, putative 0.0086 0.0081 0.0281
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0137 0.0349 0.0775
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Plasmodium falciparum calcium-dependent protein kinase 1 0.011 0.0209 0.1543
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0182 0.0583 0.0663
Trichomonas vaginalis AGC family protein kinase 0.009 0.0101 0.0429
Schistosoma mansoni amine GPCR 0.0312 0.1265 0.4286
Echinococcus multilocularis neuroglian 0.0196 0.0657 0.0747
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0063 0.0138
Echinococcus granulosus protein kinase 0.0158 0.0456 0.101
Onchocerca volvulus Neuropeptide F receptor homolog 0.0312 0.1265 0.1224
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0281 0.1105 0.245
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0115 0.0234 0.0519
Echinococcus multilocularis serine:threonine protein kinase N2 0.0083 0.0063 0.0072
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0115 0.0231 0.0231
Loa Loa (eye worm) AUR protein kinase 0.0206 0.0708 0.0708
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0708 0.4801
Loa Loa (eye worm) hypothetical protein 0.016 0.0467 0.0467
Echinococcus granulosus c-Jun N-terminal kinases 0.0518 0.2344 0.5198
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0264 0.1011 0.1151
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.011 0.0209 0.1206
Brugia malayi Protein kinase domain containing protein 0.0155 0.044 0.044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0312 0.1265 0.144
Entamoeba histolytica hypothetical protein 0.0308 0.1245 1
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0285 0.1124 0.7799
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0042 0.0066
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0178 0.056 0.1242
Echinococcus multilocularis TGF beta receptor type 1 0.0182 0.0585 0.0665
Brugia malayi Protein kinase domain containing protein 0.0308 0.1245 0.1245
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0367 0.1556 0.177
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0121 0.0266 0.0266
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0106 0.0186 0.104
Schistosoma mansoni tyrosine kinase 0.0182 0.0583 0.1931
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0297 0.1185 0.8235
Echinococcus granulosus protein kinase c epsilon type 0.0115 0.0231 0.0512
Echinococcus multilocularis cyclin dependent kinase 7 0.0193 0.0642 0.073
Echinococcus multilocularis cyclin dependent kinase 19 0.0307 0.1239 0.141
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0312 0.1265 0.4286
Schistosoma mansoni neuropeptide F-like receptor 0.0312 0.1265 0.4286
Loa Loa (eye worm) hypothetical protein 0.0079 0.0042 0.0042
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.011 0.0209 0.1543
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0106 0.0186 0.0413
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0312 0.1265 0.1265
Brugia malayi Protein kinase domain containing protein 0.0594 0.2743 0.2743
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Echinococcus granulosus orexin receptor type 2 0.0312 0.1265 0.2805
Echinococcus multilocularis rhodopsin orphan GPCR 0.0312 0.1265 0.144
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.026 0.0991 0.3341
Entamoeba histolytica protein kinase, putative 0.0083 0.0063 0.0481
Brugia malayi Immunoglobulin I-set domain containing protein 0.0889 0.4294 0.4294
Onchocerca volvulus 0.0338 0.1404 0.1364
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0152 0.0427 0.0427
Brugia malayi Furin-like cysteine rich region family protein 0.0179 0.0567 0.0567
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0115 0.0234 0.0519
Echinococcus multilocularis activated cdc42 kinase 1 0.0404 0.1749 0.199
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0234 0.1388
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0231 0.0719
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Loa Loa (eye worm) G-protein coupled receptor 0.0312 0.1265 0.1265
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0312 0.1265 0.4286
Entamoeba histolytica protein kinase domain containing protein 0.0233 0.0849 0.6806
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0234 0.0854 0.0854
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0115 0.0234 0.1388
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0118 0.0118
Echinococcus multilocularis g-protein coupled receptor 0.0312 0.1265 0.144
Entamoeba histolytica protein kinase domain containing protein 0.0233 0.0849 0.6806
Echinococcus multilocularis aurora kinase A 0.0206 0.0708 0.0806
Loa Loa (eye worm) AGC/AKT protein kinase 0.009 0.0101 0.0101
Echinococcus granulosus G protein coupled receptor 139 0.0312 0.1265 0.2805
Loa Loa (eye worm) hypothetical protein 0.0222 0.0792 0.0792
Echinococcus multilocularis casein kinase I delta 0.0111 0.021 0.0239
Echinococcus multilocularis dual specificity protein kinase clk2 0.0285 0.1124 0.1279
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0307 0.1239 0.1239
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0312 0.1265 0.2805
Brugia malayi G protein-coupled receptor F59B2.13 0.0312 0.1265 0.1265
Echinococcus granulosus roundabout 2 0.0077 0.0033 0.0073
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0274 0.1069 0.1216
Onchocerca volvulus 0.0312 0.1265 0.1224
Schistosoma mansoni hypothetical protein 0.0312 0.1265 0.4286
Loa Loa (eye worm) hypothetical protein 0.0312 0.1265 0.1265
Brugia malayi Protein kinase domain containing protein 0.0093 0.0118 0.0118
Brugia malayi cyclin-dependent kinase 9 0.0076 0.0029 0.0029
Echinococcus granulosus cyclin dependent kinase 7 0.0193 0.0642 0.1423
Echinococcus granulosus neuropeptide receptor 0.0312 0.1265 0.2805

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 82 uM Inhibition of canine platelet-rich plasma agregation induced by ADP ChEMBL. 1920361
Inhibition (functional) = 5 % Inhibition of canine platelet-rich plasma induced by ADP ChEMBL. 1920361

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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