Detailed information for compound 1759770

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.433 | Formula: C20H27NO3
  • H donors: 1 H acceptors: 2 LogP: 4.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCON=C(C1=C(O)CC(CC1=O)c1c(C)cc(cc1C)C)CC
  • InChi: 1S/C20H27NO3/c1-6-16(21-24-7-2)20-17(22)10-15(11-18(20)23)19-13(4)8-12(3)9-14(19)5/h8-9,15,22H,6-7,10-11H2,1-5H3
  • InChiKey: DQFPEYARZIQXRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references
Homo sapiens galactosylceramidase No references
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.0279 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0029 0.0107
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0029 0.0051
Schistosoma mansoni neuropeptide receptor 0.0111 0.0279 0.0494
Schistosoma mansoni nAChR subunit 0.0243 0.0696 0.1232
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0136 0.0356 0.063
Loa Loa (eye worm) PAN domain-containing protein 0.0172 0.047 0.1797
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0012 0.0022
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0243 0.0696 0.0695
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0136 0.0356 0.1359
Echinococcus multilocularis lamin dm0 0.0029 0.002 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0107 0.0267 0.1017
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0029 0.0028
Schistosoma mansoni neuropeptide receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Echinococcus multilocularis sodium channel protein 0.0041 0.0055 0.0054
Onchocerca volvulus 0.0145 0.0386 0.1474
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus granulosus lamin 0.0029 0.002 0.0018
Toxoplasma gondii PAN domain-containing protein 0.1837 0.5751 1
Trichomonas vaginalis rotamase, putative 0.0033 0.0031 0.4678
Echinococcus multilocularis serotonin receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0118
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0104 0.0257 0.3481
Echinococcus multilocularis nAChR subunit 0.0136 0.0356 0.0355
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0104 0.0257 0.625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Brugia malayi Trypsin family protein 0.0145 0.0386 0.1474
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0051 0.0556
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0029 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0696 0.2662
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0111 0.0279 0.0278
Echinococcus granulosus tyrosine protein kinase Lyn 0.0185 0.0512 0.0511
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0185 0.0512 0.0511
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0029 0.0107
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0107 0.0267 0.0265
Loa Loa (eye worm) hypothetical protein 0.0172 0.047 0.1797
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0243 0.0696 0.2662
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0136 0.0356 0.063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0029 0.0107
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0243 0.0696 0.2662
Onchocerca volvulus 0.0172 0.047 0.1797
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0243 0.0696 0.0695
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0243 0.0696 0.0695
Echinococcus multilocularis lamin 0.0029 0.002 0.0018
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0185 0.0512 0.0511
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0145 0.0386 0.0683
Brugia malayi Sex muscle abnormal protein 5 0.0037 0.0042 0.0157
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0136 0.0356 0.1359
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0167 0.0455 0.0454
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0051 0.1266
Loa Loa (eye worm) GABA receptor subunit 0.0136 0.0356 0.1359
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0107 0.0267 0.1017
Toxoplasma gondii microneme protein, putative 0.0172 0.047 0.0798
Schistosoma mansoni lamin 0.0029 0.002 0.0035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0111 0.0279 0.1065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0081 0.0305
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.0279 0.0278
Onchocerca volvulus 0.0455 0.1368 0.5235
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.0512 0.0511
Entamoeba histolytica hypothetical protein 0.0136 0.0356 0.8972
Brugia malayi neuropeptide F receptor 0.0111 0.0279 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0033 0.5323
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0157
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0185 0.0512 0.0511
Onchocerca volvulus 0.0029 0.002 0.0071
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0096 0.023 0.0229
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0051 1
Echinococcus granulosus g-protein coupled receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi SRC-1 0.0185 0.0512 0.1958
Echinococcus multilocularis tyrosine protein kinase HCK 0.0148 0.0397 0.0395
Echinococcus granulosus fmrfamide receptor 0.0111 0.0279 0.0278
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0243 0.0696 0.1232
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0107 0.0267 0.0265
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni rotamase 0.0034 0.0033 0.0059
Echinococcus granulosus neuropeptide receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0107 0.0267 0.1017
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0058 0.0111 0.1406
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Echinococcus granulosus tissue type plasminogen activator 0.0249 0.0715 0.0713
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0104 0.0257 0.3481
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0243 0.0696 0.0695
Brugia malayi RE15519p 0.0111 0.0279 0.1065
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.0512 0.0511
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0696 0.2662
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0243 0.0696 0.2662
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Schistosoma mansoni hypothetical protein 0.0033 0.0032 0.0056
Plasmodium falciparum cysteine repeat modular protein 1 0.0249 0.0715 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0167 0.0455 0.0454
Echinococcus granulosus pikachurin 0.0035 0.0039 0.0037
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0104 0.0257 0.0256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0249 0.0715 0.2733
Loa Loa (eye worm) hypothetical protein 0.0172 0.047 0.1797
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0111 0.0279 0.0278
Toxoplasma gondii PAN domain-containing protein 0.0172 0.047 0.0798
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0185 0.0512 0.0511
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0111 0.0279 0.0494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Echinococcus granulosus tyrosine protein kinase Src42A 0.0162 0.0439 0.0437
Onchocerca volvulus 0.0111 0.0279 0.1065
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Loa Loa (eye worm) PAN domain-containing protein 0.0172 0.047 0.1797
Echinococcus multilocularis enteropeptidase 0.0145 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Brugia malayi neuropeptide F receptor 0.0111 0.0279 0.1065
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0029 0.0107
Schistosoma mansoni nAChR subunit 0.0243 0.0696 0.1232
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0051 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Schistosoma mansoni growth factor receptor-bound protein 0.0037 0.0042 0.0075
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0029 0.0028
Echinococcus multilocularis growth factor receptor bound protein 2 0.0037 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0145 0.0386 0.1474
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0243 0.0696 0.2662
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0037 0.0042 0.0075
Echinococcus granulosus allatostatin A receptor 0.0111 0.0279 0.0278
Onchocerca volvulus 0.0172 0.047 0.1797
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0108 0.0269 0.1026
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0029 0.0028
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0243 0.0696 0.2662
Onchocerca volvulus 0.0847 0.2612 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0033 0.0123
Onchocerca volvulus 0.0107 0.0267 0.1017
Brugia malayi Dopamine receptor 0.0111 0.0279 0.1065
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) 0.0068 0.0142 1
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0111 0.0279 0.0278
Leishmania major hypothetical protein, conserved 0.0249 0.0715 1
Onchocerca volvulus 0.0249 0.0715 0.2733
Echinococcus multilocularis tyrosine protein kinase Srms 0.0167 0.0455 0.0454
Loa Loa (eye worm) hypothetical protein 0.0145 0.0386 0.1474
Echinococcus granulosus intermediate filament protein 0.0029 0.002 0.0018
Echinococcus granulosus glycine receptor subunit beta 0.0243 0.0696 0.0695
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0145 0.0386 0.0385
Echinococcus granulosus geminin 0.019 0.0529 0.0527
Brugia malayi Trypsin-like protease protein 5 0.0145 0.0386 0.1474
Brugia malayi hypothetical protein 0.0107 0.0267 0.1017
Loa Loa (eye worm) ACC-1 protein 0.0243 0.0696 0.2662
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0208 0.0207
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0111 0.0279 0.1065
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Echinococcus granulosus tyrosine protein kinase Src64B 0.0185 0.0512 0.0511
Brugia malayi laminin alpha chain 0.0035 0.0039 0.0144
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0029 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0051 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0107 0.0267 0.0472
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0029 0.0051
Schistosoma mansoni hypothetical protein 0.0249 0.0715 0.1264
Onchocerca volvulus 0.0172 0.047 0.1797
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Schistosoma mansoni opsin-like receptor 0.0111 0.0279 0.0494
Echinococcus granulosus expressed protein 0.0034 0.0033 0.0032
Schistosoma mansoni amine GPCR 0.0111 0.0279 0.0494
Loa Loa (eye worm) TYRA-2 protein 0.0111 0.0279 0.1065
Echinococcus multilocularis musashi 0.0029 0.002 0.0018
Brugia malayi Protein kinase domain containing protein 0.0024 0.0001 0.0001
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0243 0.0696 0.0695
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0111 0.0279 0.1065
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0104 0.0257 0.3481
Schistosoma mansoni acetylcholine receptor-related 0.0107 0.0267 0.0472
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0243 0.0696 0.0695
Echinococcus granulosus 7tm_1 domain containing protein 0.0111 0.0279 0.0278
Schistosoma mansoni adapter molecule crk 0.0037 0.0042 0.0075
Brugia malayi Trypsin family protein 0.0145 0.0386 0.1474
Loa Loa (eye worm) calcium channel 0.0096 0.023 0.0877
Loa Loa (eye worm) acetylcholine receptor protein 0.0107 0.0267 0.1017
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0096 0.023 0.0229
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0172 0.047 0.1797
Loa Loa (eye worm) abnormal epIthelia family member 0.0035 0.0039 0.0144
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis neurogenic locus notch protein 0.0035 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Brugia malayi Dopamine receptor protein 2 0.0111 0.0279 0.1065
Schistosoma mansoni neuropeptide f receptor 76f 0.0111 0.0279 0.0494
Brugia malayi EGF-like domain containing protein 0.004 0.0052 0.0195
Onchocerca volvulus 0.0029 0.002 0.0071
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi SH2 domain containing protein 0.0024 0.0001 0.0001
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0243 0.0696 0.2662
Onchocerca volvulus 0.0111 0.0279 0.1065
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.0279 0.1065
Echinococcus granulosus tachykinin peptides receptor 99D 0.0111 0.0279 0.0278
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0243 0.0696 0.0695
Schistosoma mansoni neurotransmitter gated ion channel 0.0107 0.0267 0.0472
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0051 1
Schistosoma mansoni alpha-glucosidase 0.0153 0.0412 0.0728
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0096 0.023 0.0877
Echinococcus granulosus glycine receptor subunit alpha 1 0.0243 0.0696 0.0695
Brugia malayi Dopamine receptor protein 1 0.0111 0.0279 0.1065
Echinococcus granulosus lamin dm0 0.0029 0.002 0.0018
Echinococcus granulosus peptide allatostatin:somatostatin 0.0111 0.0279 0.0278
Schistosoma mansoni tyrosine kinase 0.0042 0.0059 0.0104
Brugia malayi putative neuropeptide receptor NPR1 0.0111 0.0279 0.1065
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0111 0.0279 0.0278
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.0279 0.1065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0029 0.0028
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0031 0.026
Schistosoma mansoni hypothetical protein 0.0111 0.0279 0.0494
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0185 0.0512 0.0511
Schistosoma mansoni voltage-gated cation channel 0.0096 0.023 0.0407
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0208 0.0207
Echinococcus multilocularis G protein coupled receptor 139 0.0111 0.0279 0.0278
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0068 0.0142 1
Trichomonas vaginalis rotamase, putative 0.0034 0.0033 0.5323
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Toxoplasma gondii subtilisin SUB12 0.0172 0.047 0.0798
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0886 0.2734 0.4835
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0042 0.0059 0.0057
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0243 0.0696 0.0695
Schistosoma mansoni tyrosine kinase 0.0185 0.0512 0.0906
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0029 0.0107
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0037 0.0042 0.0157
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Brugia malayi AKH receptor 0.0111 0.0279 0.1065
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0104 0.0257 0.625
Brugia malayi Protein kinase domain containing protein 0.0024 0.0001 0.0001
Schistosoma mansoni laminin gamma-3 chain 0.004 0.0052 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0104 0.0256 0.0975
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0279 0.0278
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0031 0.0032
Onchocerca volvulus 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0243 0.0696 0.2662
Echinococcus multilocularis tyrosine protein kinase Abl 0.0042 0.0059 0.0057
Brugia malayi sulfakinin receptor protein 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0111 0.0279 0.1065
Echinococcus granulosus NCK adaptor protein 0.0037 0.0042 0.0041
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.0512 0.0511
Echinococcus granulosus glycine receptor subunit alpha 1 0.0243 0.0696 0.0695
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Brugia malayi Melatonin receptor type 1A 0.0111 0.0279 0.1065
Echinococcus granulosus tyrosine protein kinase Blk 0.0167 0.0455 0.0454
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0145 0.0386 0.0385
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0051 0.0193
Echinococcus multilocularis tissue type plasminogen activator 0.0249 0.0715 0.0713
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0029 0.0028
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0243 0.0696 0.2662
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0036 0.0042 0.0155
Echinococcus multilocularis nAChR subunit 0.0243 0.0696 0.0695
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0162 0.0439 0.0437
Brugia malayi Protein kinase domain containing protein 0.0024 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0696 0.2662
Echinococcus granulosus biogenic amine 5HT receptor 0.0111 0.0279 0.0278
Echinococcus multilocularis neuropeptide FF receptor 2 0.0111 0.0279 0.0278
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0041 0.0055 0.0054
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0029 0.0051
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Onchocerca volvulus Putative nachr subunit 0.0243 0.0696 0.2662
Toxoplasma gondii PAN domain-containing protein 0.0172 0.047 0.0798
Schistosoma mansoni tyrosine kinase 0.0024 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0144
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni neurotransmitter gated ion channel 0.0136 0.0356 0.063
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.0279 0.0278
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0104 0.0257 0.3481
Onchocerca volvulus 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0036 0.0042 0.0155
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0243 0.0696 0.0695
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0107 0.0267 0.1017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0029 0.0107
Brugia malayi ORL1-like opioid receptor 0.0111 0.0279 0.1065
Toxoplasma gondii microneme protein MIC4 0.0172 0.047 0.0798
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0051 0.0556
Echinococcus granulosus hypothetical protein 0.0111 0.0279 0.0278
Schistosoma mansoni nAChR subunit 0.0107 0.0267 0.0472
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.0042 0.0051
Schistosoma mansoni adenoreceptor 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0145 0.0386 0.1474
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0042 0.0059 0.0057
Brugia malayi steroid hormone receptor 0.0032 0.0029 0.0107
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0096 0.023 0.0877
Onchocerca volvulus 0.0243 0.0696 0.2662
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0096 0.023 0.0229
Echinococcus multilocularis serotonin receptor 0.0111 0.0279 0.0278
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0051 1
Brugia malayi hypothetical protein 0.0024 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0029 0.0107
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0172 0.047 0.1797
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.0279 0.1065
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0185 0.0512 0.0511
Onchocerca volvulus 0.0172 0.047 0.1797
Loa Loa (eye worm) hypothetical protein 0.0455 0.1368 0.5235
Echinococcus granulosus alpha 1A adrenergic receptor 0.0111 0.0279 0.0278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0696 0.2662
Brugia malayi hypothetical protein 0.0107 0.0267 0.1017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0144
Echinococcus multilocularis neuropeptide receptor A26 0.0111 0.0279 0.0278
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0051 0.0193
Onchocerca volvulus 0.0172 0.047 0.1797
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0111 0.0279 0.0494
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.0279 0.0278
Onchocerca volvulus 0.0455 0.1368 0.5235
Brugia malayi hypothetical protein 0.0107 0.0267 0.1017
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0104 0.0257 0.3481
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0012 0.0279
Loa Loa (eye worm) hypothetical protein 0.0145 0.0386 0.1474
Brugia malayi G-protein coupled receptor 0.0111 0.0279 0.1065
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0029 0.0051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0155
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.002 0.0071
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0104 0.0257 0.5
Loa Loa (eye worm) hypothetical protein 0.0847 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Echinococcus granulosus neuropeptide receptor A26 0.0111 0.0279 0.0278
Echinococcus multilocularis sex peptide receptor 0.0111 0.0279 0.0278
Schistosoma mansoni tyrosine kinase 0.0024 0.0001 0.0003
Onchocerca volvulus 0.0172 0.047 0.1797
Toxoplasma gondii microneme protein MIC17C 0.0172 0.047 0.0798
Onchocerca volvulus 0.0036 0.0042 0.0155
Schistosoma mansoni hypothetical protein 0.019 0.0529 0.0935
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Echinococcus granulosus tyrosine kinase 0.0167 0.0455 0.0454
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.0279 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0029 0.0107
Onchocerca volvulus 0.0111 0.0279 0.1065
Schistosoma mansoni intermediate filament proteins 0.0029 0.002 0.0035
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Onchocerca volvulus 0.0111 0.0279 0.1065
Schistosoma mansoni opsin-like receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Echinococcus granulosus glycoprotein Antigen 5 0.0145 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0455 0.1368 0.5235
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) 0.0068 0.0142 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0037 0.0042 0.0041
Schistosoma mansoni histamine h1 receptor 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0024 0.0001 0.0001
Schistosoma mansoni alpha-glucosidase 0.0153 0.0412 0.0728
Schistosoma mansoni biogenic amine receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) LGC-31 protein 0.0243 0.0696 0.2662
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0029 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.0279 0.0278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0029 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0029 0.0107
Onchocerca volvulus 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0104 0.0256 0.0975
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0012 0.0044
Schistosoma mansoni acetylcholine receptor subunit beta 0.0107 0.0267 0.0472
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0081 0.0305
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.049 0.0489
Schistosoma mansoni hypothetical protein 0.0111 0.0279 0.0494
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Echinococcus multilocularis pikachurin 0.0035 0.0039 0.0037
Onchocerca volvulus 0.0172 0.047 0.1797
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Loa Loa (eye worm) hypothetical protein 0.0172 0.047 0.1797
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Brugia malayi Tachykinin-like peptides receptor 99D 0.0111 0.0279 0.1065
Echinococcus granulosus glycine receptor subunit alpha 1 0.0243 0.0696 0.0695
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0031 0.074
Loa Loa (eye worm) TK/ABL protein kinase 0.0024 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Onchocerca volvulus 0.0107 0.0267 0.1017
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0111 0.0279 0.1065
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0029 0.0051
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0243 0.0696 0.1232
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.049 0.0489
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0104 0.0257 0.098
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Toxoplasma gondii PAN domain-containing protein 0.1837 0.5751 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.049 0.0489
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0096 0.023 0.0229
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0107 0.0267 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0145 0.0386 0.1474
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0111 0.0279 0.1065
Schistosoma mansoni growth factor receptor-bound protein 0.0037 0.0042 0.0075
Onchocerca volvulus 0.0145 0.0386 0.1474
Loa Loa (eye worm) hypothetical protein 0.0172 0.047 0.1797
Onchocerca volvulus 0.0111 0.0279 0.1065
Schistosoma mansoni amine GPCR 0.0111 0.0279 0.0494
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni amine GPCR 0.0111 0.0279 0.0494
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0111 0.0279 0.0278
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.049 0.1872
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0058 0.0111 0.4038
Echinococcus multilocularis tyrosine protein kinase Blk 0.0167 0.0455 0.0454
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0031 0.026
Schistosoma mansoni neuropeptide receptor 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0111 0.0279 0.1065
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Loa Loa (eye worm) TK protein kinase 0.0148 0.0397 0.1515
Toxoplasma gondii microneme protein MIC17A 0.0172 0.047 0.0798
Schistosoma mansoni nAChR subunit 0.0107 0.0267 0.0472
Onchocerca volvulus 0.0104 0.0256 0.0975
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi GnHR receptor homolog 0.0111 0.0279 0.1065
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0104 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0847 0.2612 1
Echinococcus multilocularis NCK adaptor protein 0.0037 0.0042 0.0041
Echinococcus multilocularis geminin 0.019 0.0529 0.0527
Echinococcus granulosus sex peptide receptor 0.0111 0.0279 0.0278
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0104 0.0257 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Echinococcus multilocularis G-protein coupled receptor, putative 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0145 0.0386 0.1474
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0104 0.0257 0.0454
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0051 0.005
Loa Loa (eye worm) intermediate filament protein 0.0029 0.002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0081 0.0305
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0111 0.0279 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0029 0.0107
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.0279 0.0494
Echinococcus multilocularis allatostatin A receptor 0.0111 0.0279 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0029 0.0107
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0243 0.0696 0.0695
Echinococcus granulosus tyrosine protein kinase Src42A 0.0185 0.0512 0.0511
Loa Loa (eye worm) TK/ROR protein kinase 0.0254 0.0731 0.2796
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0111 0.0279 0.1065
Echinococcus multilocularis neuropeptide s receptor 0.0111 0.0279 0.0278
Schistosoma mansoni amine GPCR 0.0111 0.0279 0.0494
Schistosoma mansoni serine-type protease inhibitor 0.1807 0.5654 1
Brugia malayi follicle stimulating hormone receptor 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0172 0.047 0.1797
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0029 0.0107
Schistosoma mansoni tyrosine kinase 0.0185 0.0512 0.0906
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0243 0.0696 0.0695
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0136 0.0356 0.1359
Brugia malayi Protein kinase domain containing protein 0.0254 0.0731 0.2796
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.002 0.0071
Loa Loa (eye worm) PAN domain-containing protein 0.0172 0.047 0.1797
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0243 0.0696 0.0695
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0107 0.0267 0.0265
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0107 0.0267 0.1017
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0012 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Echinococcus multilocularis orexin receptor type 2 0.0111 0.0279 0.0278
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0012 0.0022
Brugia malayi intermediate filament protein 0.0029 0.002 0.0071
Echinococcus granulosus tyrosine protein kinase HCK 0.0148 0.0397 0.0395
Onchocerca volvulus 0.0111 0.0279 0.1065
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.0279 0.0494
Brugia malayi G protein-coupled receptor F59B2.13 0.0111 0.0279 0.1065
Schistosoma mansoni hypothetical protein 0.0145 0.0386 0.0683
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0051 0.1266
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0164 0.0447 0.0791
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3178 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0111 0.0279 0.1065
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0068 0.0142 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0243 0.0696 0.2662
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni slit 0.004 0.0052 0.0092
Brugia malayi nuclear hormone receptor 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0071
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0104 0.0257 0.0426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Echinococcus multilocularis neuropeptide receptor 0.0111 0.0279 0.0278
Brugia malayi Serotonin receptor 0.0111 0.0279 0.1065
Echinococcus granulosus g protein coupled receptor 0.0111 0.0279 0.0278
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0455 0.1368 0.242
Echinococcus granulosus slit 2 protein 0.004 0.0052 0.0051
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0243 0.0696 0.2662
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0051 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0029 0.0051
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0172 0.047 0.0798
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0029 0.0028
Echinococcus granulosus c src tyrosine kinase 0.0042 0.0059 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Onchocerca volvulus 0.0136 0.0356 0.1359
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0104 0.0256 0.0975
Loa Loa (eye worm) trypsin family protein 0.0145 0.0386 0.1474
Echinococcus multilocularis transmembrane protease serine 3 0.0145 0.0386 0.0385
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0012 0.0044
Brugia malayi G-protein coupled receptor 0.0111 0.0279 0.1065
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0249 0.0715 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Toxoplasma gondii hypothetical protein 0.0172 0.047 0.0798
Schistosoma mansoni opsin-like receptor 0.0111 0.0279 0.0494
Echinococcus multilocularis c src tyrosine kinase 0.0042 0.0059 0.0057
Onchocerca volvulus Fatty acid synthase homolog 0.0036 0.0042 0.0155
Brugia malayi excitatory GABA receptor EXP-1A 0.0243 0.0696 0.2662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0029 0.0107
Brugia malayi hypothetical protein 0.0145 0.0386 0.1474
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0243 0.0696 0.2662
Echinococcus granulosus g protein coupled receptor 0.0111 0.0279 0.0278
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0847 0.2612 0.4621
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0051 0.0068
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0042 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0029 0.0051
Onchocerca volvulus 0.0172 0.047 0.1797
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0051 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0042 0.0059 0.0104
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0111 0.0279 0.0278
Onchocerca volvulus 0.0111 0.0279 0.1065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0107 0.0267 0.1017
Echinococcus granulosus enteropeptidase 0.0145 0.0386 0.0385
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0031 0.0747
Echinococcus multilocularis dro:myosuppressin receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) PAN domain-containing protein 0.0172 0.047 0.1797
Brugia malayi Protein kinase domain containing protein 0.0024 0.0001 0.0001
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni neuropeptide receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi hypothetical protein 0.0107 0.0267 0.1017
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0029 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0051 0.0556
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0111 0.0279 0.0278
Onchocerca volvulus 0.0024 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0696 0.2662
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0096 0.023 0.0407
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.0279 0.0278
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0279 0.0278
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0243 0.0696 0.0695
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Brugia malayi nuclear receptor NHR-88 0.0032 0.0029 0.0107
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0032 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0715 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0243 0.0696 0.2662
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0107 0.0267 0.1017
Onchocerca volvulus 0.0111 0.0279 0.1065
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.0042 0.0051
Echinococcus granulosus transmembrane protease serine 3 0.0145 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0172 0.047 0.1797
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0111 0.0279 0.0278
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0243 0.0696 0.2662
Echinococcus multilocularis glycine receptor subunit beta 0.0243 0.0696 0.0695
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0029 0.0107
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0096 0.023 0.0407
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0081 0.0305
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0012 0.0011
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Schistosoma mansoni lamin 0.0029 0.002 0.0035
Brugia malayi ecdysteroid receptor 0.0032 0.0029 0.0107
Brugia malayi hypothetical protein 0.0107 0.0267 0.1017
Brugia malayi laminin-like protein K08C7.3 precursor 0.0035 0.0039 0.0144
Echinococcus multilocularis expressed protein 0.0034 0.0033 0.0032
Onchocerca volvulus 0.0172 0.047 0.1797
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0104 0.0257 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0029 0.0028
Schistosoma mansoni biogenic amine (5HT) receptor 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0104 0.0256 0.0975
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0145 0.0386 0.1474
Onchocerca volvulus 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0024 0.0001 0.0001
Schistosoma mansoni growth hormone secretagogue receptor 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0103 0.0252 0.0962
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0279 0.0494
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0136 0.0356 0.1359
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0104 0.0257 0.098
Echinococcus multilocularis neuropeptide receptor 0.0111 0.0279 0.0278
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0136 0.0356 0.1359
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0145 0.0386 0.1474
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Echinococcus multilocularis glycine receptor subunit beta 0.0243 0.0696 0.0695
Onchocerca volvulus 0.0145 0.0386 0.1474
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.0279 0.0278
Schistosoma mansoni nAChR subunit 0.0243 0.0696 0.1232
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0243 0.0696 0.0695
Schistosoma mansoni hypothetical protein 0.0104 0.0256 0.0452
Echinococcus granulosus nAChR subunit 0.0136 0.0356 0.0355
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0243 0.0696 0.1232
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0035 0.0039 0.0068
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0111 0.0279 0.0278
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0051 1
Echinococcus granulosus g protein coupled receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis somatostatin receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0455 0.1368 0.242
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0036 0.0042 0.0051
Schistosoma mansoni hypothetical protein 0.0145 0.0386 0.0683
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.0279 0.0278
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.0512 0.0511
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0096 0.023 0.0229
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) SRC-1 0.0185 0.0512 0.1958
Brugia malayi putative neuropeptide receptor 0.0111 0.0279 0.1065
Brugia malayi Cation transporter family protein 0.0243 0.0696 0.2662
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0035 0.0039 0.0144
Loa Loa (eye worm) hypothetical protein 0.004 0.0052 0.0195
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Onchocerca volvulus 0.0111 0.0279 0.1065
Echinococcus granulosus neuropeptide receptor 0.0111 0.0279 0.0278
Toxoplasma gondii PAN domain-containing protein 0.0172 0.047 0.0798
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0012 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0029 0.0051
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0243 0.0696 0.2662
Toxoplasma gondii kringle domain-containing protein 0.0249 0.0715 0.1224
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Schistosoma mansoni alpha glucosidase 0.0039 0.0051 0.0091
Schistosoma mansoni cell polarity protein 0.0035 0.0039 0.0068
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.049 0.1872
Loa Loa (eye worm) hypothetical protein 0.0347 0.1028 0.3932
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi protein-tyrosine kinase 0.0167 0.0455 0.1739
Schistosoma mansoni coup transcription factor 0.0032 0.0029 0.0051
Brugia malayi Serotonin receptor 0.0111 0.0279 0.1065
Echinococcus multilocularis glycoprotein Antigen 5 0.0145 0.0386 0.0385
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0037 0.0042 0.0157
Brugia malayi PAN domain containing protein 0.0172 0.047 0.1797
Schistosoma mansoni myosin xvIII 0.0111 0.0279 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0029 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) TK protein kinase 0.0167 0.0455 0.1739
Brugia malayi Cation transporter family protein 0.0455 0.1368 0.5235
Loa Loa (eye worm) hypothetical protein 0.0038 0.0048 0.0178
Schistosoma mansoni nAChR subunit 0.0243 0.0696 0.1232
Onchocerca volvulus 0.0243 0.0696 0.2662
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0243 0.0696 0.0695
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0386 0.0683
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.0512 0.0511
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0031 0.026
Echinococcus granulosus dro:myosuppressin receptor 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Brugia malayi Muscle positioning protein 4 0.0108 0.0269 0.1026
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0243 0.0696 0.0695
Onchocerca volvulus 0.0172 0.047 0.1797
Echinococcus granulosus G protein coupled receptor 139 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0029 0.0107
Schistosoma mansoni nAChR subunit 0.0243 0.0696 0.1232
Echinococcus granulosus nAChR subunit 0.0243 0.0696 0.0695
Echinococcus granulosus orexin receptor type 2 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi Tyrosine-protein kinase abl-1 0.0042 0.0059 0.022
Schistosoma mansoni nAChR subunit 0.0243 0.0696 0.1232
Schistosoma mansoni biogenic amine receptor 0.0111 0.0279 0.0494
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0051 0.005
Brugia malayi Trypsin family protein 0.0145 0.0386 0.1474
Mycobacterium ulcerans hypothetical protein 0.0145 0.0386 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0136 0.0356 0.1359
Entamoeba histolytica protein kinase, putative 0.0148 0.0397 1
Schistosoma mansoni hypothetical protein 0.019 0.0529 0.0935
Schistosoma mansoni nck2/grb4 0.0037 0.0042 0.0075
Loa Loa (eye worm) PAN domain-containing protein 0.0172 0.047 0.1797
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0012 0.0022
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0243 0.0696 0.2662
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.0279 0.0278
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Loa Loa (eye worm) ACC-1 protein 0.0243 0.0696 0.2662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0029 0.0107
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0029 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0696 0.2662
Schistosoma mansoni serine-type protease inhibitor 0.1807 0.5654 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0107 0.0267 0.1017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0243 0.0696 0.0695
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0111 0.0279 0.0278
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Toxoplasma gondii hypothetical protein 0.0172 0.047 0.0798
Onchocerca volvulus Neuropeptide F receptor homolog 0.0111 0.0279 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0029 0.0107
Onchocerca volvulus 0.0107 0.0267 0.1017
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0051 1
Schistosoma mansoni nAChR subunit 0.0243 0.0696 0.1232
Brugia malayi larval opioid receptor 0.0111 0.0279 0.1065
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0243 0.0696 0.2662
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0243 0.0696 0.0695
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0185 0.0512 0.0511
Loa Loa (eye worm) hypothetical protein 0.0038 0.0048 0.0178
Brugia malayi Variant SH3 domain containing protein 0.0037 0.0042 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0065
Brugia malayi Protein kinase domain containing protein 0.0024 0.0001 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0029 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus granulosus glycine receptor subunit beta 0.0243 0.0696 0.0695
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0243 0.0696 0.2662
Echinococcus multilocularis voltage dependent calcium channel 0.0096 0.023 0.0229
Echinococcus granulosus biogenic amine 5HT receptor 0.0111 0.0279 0.0278
Schistosoma mansoni biogenic amine (5HT) receptor 0.0111 0.0279 0.0494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Schistosoma mansoni hypothetical protein 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0111 0.0279 0.1065
Echinococcus multilocularis Mastin 0.0145 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.0279 0.0278
Echinococcus granulosus neuropeptide FF receptor 2 0.0111 0.0279 0.0278
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0111 0.0279 0.0278
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0111 0.0279 0.0278
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.0279 0.0278
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0145 0.0386 0.0385
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0029 0.0051
Echinococcus granulosus neurogenic locus notch protein 0.0035 0.0039 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0029 0.0028
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.0279 0.0494
Onchocerca volvulus 0.0024 0.0001 0.0001
Onchocerca volvulus 0.0455 0.1368 0.5235
Echinococcus granulosus serotonin receptor 0.0111 0.0279 0.0278
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0386 0.0683
Brugia malayi G protein-coupled receptor 0.0111 0.0279 0.1065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0279 0.0494
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0096 0.023 0.0229
Onchocerca volvulus 0.0024 0.0001 0.0001
Echinococcus granulosus somatostatin receptor 0.0111 0.0279 0.0278
Brugia malayi Kringle domain containing protein 0.0249 0.0715 0.2733
Schistosoma mansoni tyrosine kinase 0.0042 0.0059 0.0104
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0107 0.0267 0.0265
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0386 0.0683
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0386 0.0683
Toxoplasma gondii PAN/Apple domain-containing protein 0.0172 0.047 0.0798
Brugia malayi CUB domain containing protein 0.0038 0.0048 0.0178
Brugia malayi SH2 domain containing protein 0.0024 0.0001 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0029 0.0028
Echinococcus granulosus Mastin 0.0145 0.0386 0.0385
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0096 0.023 0.0229
Toxoplasma gondii PAN domain-containing protein 0.0172 0.047 0.0798
Echinococcus granulosus voltage dependent calcium channel 0.0096 0.023 0.0229
Echinococcus multilocularis fmrfamide receptor 0.0111 0.0279 0.0278
Echinococcus multilocularis g-protein coupled receptor 0.0111 0.0279 0.0278
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0107
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0033 0.0123
Brugia malayi hypothetical protein 0.0111 0.0279 0.1065
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.1017
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0111 0.0279 0.0278
Schistosoma mansoni amine GPCR 0.0111 0.0279 0.0494
Echinococcus multilocularis voltage dependent calcium channel 0.0096 0.023 0.0229
Echinococcus multilocularis slit 2 protein 0.004 0.0052 0.0051
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0035 0.0062
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0111 0.0279 0.0278
Schistosoma mansoni hypothetical protein 0.0111 0.0279 0.0494
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.0279 0.0278
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0029 0.0028
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0111 0.0279 0.1065
Onchocerca volvulus 0.0108 0.0269 0.1026
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0279 0.0278
Schistosoma mansoni biogenic amine receptor 0.0111 0.0279 0.0494
Brugia malayi Trypsin family protein 0.0847 0.2612 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0029 0.0107
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Toxoplasma gondii microneme protein MIC17B 0.0172 0.047 0.0798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0029 0.0028
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0386 0.0683
Brugia malayi Cation transporter family protein 0.0243 0.0696 0.2662
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0111 0.0279 0.0494
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0029 0.0051
Trypanosoma brucei glucosidase, putative 0.0039 0.0051 0.1596
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.0512 0.0511
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0155
Echinococcus granulosus 7TM GPCR rhodopsin 0.0111 0.0279 0.0278
Loa Loa (eye worm) DOMON domain-containing protein 0.0104 0.0256 0.0975
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0243 0.0696 0.1232
Onchocerca volvulus 0.0702 0.2153 0.824
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0185 0.0512 0.0511
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0001 0.0001
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0243 0.0696 0.2662
Brugia malayi SEA domain containing protein 0.0104 0.0256 0.0975
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.0279 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.1065
Brugia malayi Variant SH3 domain containing protein 0.0037 0.0042 0.0157
Onchocerca volvulus 0.0111 0.0279 0.1065
Echinococcus multilocularis fmrfamide receptor 0.0111 0.0279 0.0278

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3794 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9494 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.2892 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.8724 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 68.5199 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.