TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.551 | Formula: C25H36O4
H donors: 2 H acceptors: 3 LogP: 7.02 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCC(c1cc(O)c2c(c1)OC([C@H]1C2CC(=CC1)C(=O)O)(C)C)(C)C
InChi: 1S/C25H36O4/c1-6-7-8-9-12-24(2,3)17-14-20(26)22-18-13-16(23(27)28)10-11-19(18)25(4,5)29-21(22)15-17/h10,14-15,18-19,26H,6-9,11-13H2,1-5H3,(H,27,28)/t18?,19-/m1/s1
InChiKey: YCHYFHOSGQABSW-MUMRKEEXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Rattus norvegicus	Cannabinoid CB1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	RNA, U transporter 1	0.0096	0.0348	0.0391
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0146	0.0572	0.0572
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0146	0.0572	0.0572
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0146	0.0572	0.0656
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0146	0.0572	0.0572
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1424	0.6278	1
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0146	0.0572	0.0642
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0642	0.2787	0.3266
Echinococcus granulosus	importin subunit beta 1	0.0034	0.007	0.007
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Entamoeba histolytica	hypothetical protein	0.0123	0.0471	0.0522
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0123	0.0471	0.0471
Echinococcus multilocularis	calcium activated potassium channel	0.0146	0.0572	0.0572
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0123	0.0471	0.0522
Echinococcus multilocularis	sodium channel protein	0.2257	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0123	0.0471	0.0536
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0123	0.0471	0.0471
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0123	0.0471	0.0471
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.007	0.007
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0146	0.0572	0.0656
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0123	0.0471	0.0522
Brugia malayi	Pre-SET motif family protein	0.0036	0.0082	0.0077
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0146	0.0572	0.0572
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0905	0.3963	0.466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1914	0.8469	1
Brugia malayi	cation channel family protein	0.0146	0.0572	0.0656
Trypanosoma cruzi	target of rapamycin kinase 3	0.1524	0.6727	0.7935
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0123	0.0471	0.0471
Echinococcus granulosus	hypothetical protein	0.0146	0.0572	0.0572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1033	0.4536	0.5339
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Echinococcus multilocularis	geminin	0.0198	0.0804	0.0804
Schistosoma mansoni	60S ribosomal protein L21	0.0146	0.0572	0.0675
Entamoeba histolytica	hypothetical protein	0.0042	0.0108	0.0091
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0123	0.0471	0.0522
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.007	0.0047
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0146	0.0572	0.0656
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0123	0.0471	0.0557
Toxoplasma gondii	FATC domain-containing protein	0.0362	0.1537	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0146	0.0572	0.0656
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0146	0.0572	0.0656
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0642	0.2787	0.2765
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1132	0.4977	0.5862
Echinococcus granulosus	transient receptor potential cation channel	0.0146	0.0572	0.0572
Echinococcus multilocularis	shaker cognate	0.0146	0.0572	0.0572
Trichomonas vaginalis	conserved hypothetical protein	0.0403	0.1721	0.2004
Echinococcus multilocularis	two pore calcium channel protein 2	0.0146	0.0572	0.0572
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0146	0.0572	0.0572
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1914	0.8469	1
Echinococcus multilocularis	voltage gated potassium channel	0.0146	0.0572	0.0572
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0146	0.0572	0.0572
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0123	0.0471	0.0706
Giardia lamblia	Hypothetical protein	0.0123	0.0471	0.0522
Loa Loa (eye worm)	voltage-gated calcium channel	0.0146	0.0572	0.0655
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0146	0.0572	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Trichomonas vaginalis	conserved hypothetical protein	0.0239	0.0985	0.1131
Echinococcus granulosus	TRP transient receptor potential channel	0.0146	0.0572	0.0572
Echinococcus multilocularis	transient receptor potential cation channel	0.0146	0.0572	0.0572
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0362	0.1537	0.1785
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1524	0.6727	0.7935
Echinococcus multilocularis	two pore calcium channel protein 1	0.0146	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0362	0.1537	0.1797
Schistosoma mansoni	voltage-gated cation channel	0.0146	0.0572	0.0675
Echinococcus granulosus	transient receptor potential cation channel	0.0146	0.0572	0.0572
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0128	0.0493	0.0741
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1914	0.8469	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	0.0522
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0146	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0146	0.0572	0.0867
Echinococcus granulosus	two pore calcium channel protein 1	0.0146	0.0572	0.0572
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0123	0.0471	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1424	0.6278	0.7404
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0947	0.4152	0.4152
Mycobacterium leprae	conserved hypothetical protein	0.0123	0.0471	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0146	0.0572	0.0572
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0123	0.0471	0.0522
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0522
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0123	0.0471	0.0522
Schistosoma mansoni	cpg binding protein	0.0071	0.0237	0.0279
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1914	0.8469	0.8469
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0146	0.0572	0.0572
Echinococcus granulosus	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0042	0.0013
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0146	0.0572	0.0642
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0123	0.0471	0.0471
Echinococcus granulosus	geminin	0.0198	0.0804	0.0804
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0146	0.0572	0.0675
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.2257	1	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Schistosoma mansoni	hypothetical protein	0.0123	0.0471	0.0557
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0146	0.0572	0.0656
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0123	0.0471	0.0471
Echinococcus granulosus	voltage gated potassium channel	0.0146	0.0572	0.0572
Brugia malayi	cation channel family protein	0.0146	0.0572	0.0656
Echinococcus multilocularis	dnaJ subfamily B	0.0956	0.4189	0.4189
Echinococcus granulosus	two pore calcium channel protein 2	0.0146	0.0572	0.0572
Toxoplasma gondii	transporter, cation channel family protein	0.0146	0.0572	0.0867
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0146	0.0572	0.0867
Echinococcus granulosus	dnaJ subfamily B	0.0956	0.4189	0.4189
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	0.0522
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0146	0.0572	0.0572
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0031	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1522	0.672	0.7927
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0042	0.0013
Loa Loa (eye worm)	phosphatidylinositol 3	0.0642	0.2787	0.3276
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.007	0.0064
Echinococcus multilocularis		0.0123	0.0471	0.0471
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0123	0.0471	0.0706
Echinococcus multilocularis	transient receptor potential cation channel	0.0146	0.0572	0.0572
Schistosoma mansoni	ran	0.0025	0.0031	0.0036
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0146	0.0572	0.0572
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0146	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0082	0.0076
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0146	0.0572	0.0675
Echinococcus multilocularis	potassium large conductance calcium activated	0.0146	0.0572	0.0572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1522	0.672	0.7927
Entamoeba histolytica	hypothetical protein	0.0042	0.0108	0.0091
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0146	0.0572	0.0675
Loa Loa (eye worm)	calcium channel	0.0146	0.0572	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1424	0.6278	0.7404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1424	0.6278	0.7404
Echinococcus multilocularis	transient receptor potential cation channel	0.0146	0.0572	0.0572
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0123	0.0471	0.0557
Schistosoma mansoni	voltage-dependent calcium channel	0.0146	0.0572	0.0675
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0123	0.0471	0.0522
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0642	0.2787	0.2765
Loa Loa (eye worm)	phosphatidylinositol 3	0.1914	0.8469	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0123	0.0471	0.0522
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	0.0522
Schistosoma mansoni	transient receptor potential channel 4	0.0146	0.0572	0.0675
Echinococcus granulosus	ryanodine receptor 44f	0.0146	0.0572	0.0572
Brugia malayi	Importin beta-1 subunit	0.0034	0.007	0.0063
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.028	0.117	0.117
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0146	0.0572	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Brugia malayi	olfactory channel protein osm-9	0.0146	0.0572	0.0656
Brugia malayi	Pre-SET motif family protein	0.0245	0.1012	0.1178
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0123	0.0471	0.0522
Loa Loa (eye worm)	ryanodine receptor	0.0146	0.0572	0.0655
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0123	0.0471	0.0536
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0123	0.0471	0.0522
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0522
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1914	0.8469	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0067	0.022	0.0238
Entamoeba histolytica	protein kinase rad3, putative	0.0362	0.1537	0.1785
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0642	0.2787	0.3266
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0146	0.0572	0.0675
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0146	0.0572	0.0642
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0642	0.2787	0.3266
Onchocerca volvulus		0.0278	0.1163	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0146	0.0572	0.4533
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0146	0.0572	0.0572
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0123	0.0471	0.0538
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0362	0.1537	0.1785
Loa Loa (eye worm)	ion channel NompC	0.0146	0.0572	0.0655
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0123	0.0471	0.0522
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1424	0.6278	0.7404
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1424	0.6278	0.7404
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	1
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	0.0442
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0042	0.0013
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0146	0.0572	0.0655
Schistosoma mansoni	cpg binding protein	0.0067	0.022	0.0259
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0362	0.1537	0.1815
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1424	0.6278	0.7404
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0146	0.0572	0.0572
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0123	0.0471	1
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0146	0.0572	0.0642
Schistosoma mansoni	hypothetical protein	0.028	0.117	0.1381
Loa Loa (eye worm)	hypothetical protein	0.039	0.1662	0.1945
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0123	0.0471	0.0557
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0146	0.0572	0.0572
Plasmodium vivax	hypothetical protein, conserved	0.0123	0.0471	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0146	0.0572	0.0675
Leishmania major	hypothetical protein, unknown function	0.0123	0.0471	0.0442
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0146	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.007	0.0047
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0146	0.0572	0.0675
Echinococcus multilocularis	conserved hypothetical protein	0.0146	0.0572	0.0572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1033	0.4536	0.5339
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0123	0.0471	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0146	0.0572	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1132	0.4977	0.5862
Leishmania major	hypothetical protein, conserved	0.0146	0.0572	0.0543
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1524	0.6727	0.6717
Echinococcus multilocularis	transient receptor potential cation channel	0.0146	0.0572	0.0572
Echinococcus multilocularis	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0362	0.1537	0.1537
Echinococcus granulosus	short transient receptor potential channel 6	0.0146	0.0572	0.0572
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0642	0.2787	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0034	0.007	0.0062
Echinococcus granulosus	transient receptor potential cation channel	0.0146	0.0572	0.0572
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0146	0.0572	0.0572
Brugia malayi	hypothetical protein	0.0146	0.0572	0.0656
Schistosoma mansoni	hypothetical protein	0.0198	0.0804	0.0949
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0471	0.0522
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0123	0.0471	0.0522
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0123	0.0471	0.0538
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0146	0.0572	0.0675
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0123	0.0471	0.0522
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0642	0.2787	0.3266
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	0.0522
Echinococcus granulosus	serine protein kinase ATM	0.0362	0.1537	0.1537
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0123	0.0471	0.0471
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0146	0.0572	0.0656
Echinococcus granulosus	calcium activated potassium channel	0.0146	0.0572	0.0572
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0082	0.0083
Toxoplasma gondii	transporter, cation channel family protein	0.0146	0.0572	0.0867
Onchocerca volvulus		0.0067	0.022	0.1272
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0082	0.0097
Loa Loa (eye worm)	phosphatidylinositol 3	0.0123	0.0471	0.0536
Plasmodium vivax	hypothetical protein	0.0123	0.0471	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0146	0.0572	0.0572
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0146	0.0572	0.0675
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0362	0.1537	0.1537
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0642	0.2787	0.3277
Trichomonas vaginalis	conserved hypothetical protein	0.028	0.117	0.135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0239	0.0985	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0146	0.0572	0.0675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1242	0.547	0.6446
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0123	0.0471	0.0471
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0146	0.0572	0.0656
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0123	0.0471	0.0522
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0642	0.2787	0.3266
Plasmodium vivax	SET domain protein, putative	0.0036	0.0082	0.117
Toxoplasma gondii	hypothetical protein	0.0146	0.0572	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0146	0.0572	0.0675
Entamoeba histolytica	hypothetical protein	0.0123	0.0471	0.0522
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0146	0.0572	0.0572
Toxoplasma gondii	hypothetical protein	0.0146	0.0572	0.0867
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0123	0.0471	0.0471
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0123	0.0471	0.0471
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0123	0.0471	0.0522
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0442
Echinococcus granulosus	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0522
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.0031	0.0015
Schistosoma mansoni	transient receptor potential channel	0.0146	0.0572	0.0675
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Echinococcus multilocularis	cpg binding protein	0.0071	0.0237	0.0237
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0514	0.2214	0.2587
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0146	0.0572	0.0572
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0123	0.0471	0.0557
Echinococcus multilocularis	sodium leak channel non selective protein	0.0146	0.0572	0.0572
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0146	0.0572	0.0572
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0239	0.0985	0.1131
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0795	0.3471	0.4077
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0146	0.0572	0.0572
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.007	0.007
Echinococcus granulosus	voltage gated potassium channel	0.0146	0.0572	0.0572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1914	0.8469	1
Entamoeba histolytica	hypothetical protein	0.0123	0.0471	0.0522
Echinococcus multilocularis	voltage dependent calcium channel	0.0146	0.0572	0.0572
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0123	0.0471	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Echinococcus multilocularis	transfer RNA-Gly	0.0146	0.0572	0.0572
Echinococcus granulosus	transient receptor potential gamma protein	0.0146	0.0572	0.0572
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0123	0.0471	0.0522
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0022	0.0018	0.0018
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1914	0.8469	1
Onchocerca volvulus		0.0123	0.0471	0.3603
Entamoeba histolytica	hypothetical protein	0.0362	0.1537	0.1785
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1634	0.7219	0.8519
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0522
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0146	0.0572	0.4533
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0123	0.0471	0.0538
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0642	0.2787	0.2787
Leishmania major	hypothetical protein, unknown function	0.0146	0.0572	0.0543
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0123	0.0471	0.0522
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0123	0.0471	0.0522
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1522	0.672	0.7927
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1144	0.5028	0.5922
Schistosoma mansoni	hypothetical protein	0.036	0.1526	0.1802
Brugia malayi	FAT domain containing protein	0.028	0.117	0.1364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1144	0.5028	0.5922
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0362	0.1537	0.1815
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1522	0.672	0.7927
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0146	0.0572	0.0656
Echinococcus granulosus	shaker cognate	0.0146	0.0572	0.0572
Loa Loa (eye worm)	voltage-gated potassium channel	0.0146	0.0572	0.0655
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1914	0.8469	0.8469
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0123	0.0471	1
Plasmodium falciparum	importin beta, putative	0.0034	0.007	0.0901
Entamoeba histolytica	hypothetical protein	0.0042	0.0108	0.0091
Echinococcus multilocularis	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Schistosoma mansoni	hypothetical protein	0.0146	0.0572	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0471	0.0536
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0146	0.0572	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0146	0.0572	0.0572
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0522
Trichomonas vaginalis	set domain proteins, putative	0.0278	0.1163	0.1341
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0146	0.0572	0.0675
Echinococcus multilocularis	serine protein kinase ATM	0.0362	0.1537	0.1537
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0146	0.0572	0.0572
Onchocerca volvulus		0.0123	0.0471	0.3603
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0362	0.1537	0.1785
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0123	0.0471	0.0538
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1284	0.5654	0.6665
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0245	0.1012	0.1176
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0123	0.0471	0.0522
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0123	0.0471	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0146	0.0572	0.0656
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0146	0.0572	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1144	0.5028	0.5922
Echinococcus multilocularis	ryanodine receptor 44f	0.0146	0.0572	0.0572
Echinococcus granulosus	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.028	0.117	0.1363
Loa Loa (eye worm)	hypothetical protein	0.0239	0.0985	0.1144
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0146	0.0572	0.0656
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1033	0.4536	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0642	0.2787	0.3266
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0522
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.4529	0.5331
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0146	0.0572	0.0675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0362	0.1537	0.1785
Echinococcus granulosus	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0146	0.0572	0.0572
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0146	0.0572	0.0572
Brugia malayi	ion channel NompC	0.0146	0.0572	0.0656
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0082	0.0097
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0146	0.0572	0.0656
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0642	0.2787	0.2787
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0042	0.0013
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0123	0.0471	0.0538
Echinococcus granulosus	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0123	0.0471	0.0538
Brugia malayi	Transient-receptor-potential like protein	0.0146	0.0572	0.0656
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0146	0.0572	0.0572
Entamoeba histolytica	hypothetical protein	0.0123	0.0471	0.0522
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0146	0.0572	0.0572
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0123	0.0471	0.0471
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0362	0.1537	0.1798
Schistosoma mansoni	transient receptor potential channel	0.0146	0.0572	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0403	0.1721	0.2015
Giardia lamblia	GTOR	0.1914	0.8469	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0123	0.0471	0.0471
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0082	0.0097
Schistosoma mansoni	two-pore calcium channel	0.0146	0.0572	0.0675
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0362	0.1537	0.1785
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.0031	0.0031
Schistosoma mansoni	hypothetical protein	0.0956	0.4189	0.4946
Echinococcus multilocularis	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0146	0.0572	0.0572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0362	0.1537	0.1785
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.4529	0.5331
Echinococcus granulosus	transient receptor potential cation channel	0.0146	0.0572	0.0572
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0146	0.0572	0.0642
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1914	0.8469	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0146	0.0572	0.0572
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0146	0.0572	0.0572
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0108	0.0108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1033	0.4536	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0471	0.0536
Echinococcus multilocularis	transient receptor potential cation channel	0.0146	0.0572	0.0572
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0042	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1424	0.6278	0.7404
Toxoplasma gondii	transporter, cation channel family protein	0.0146	0.0572	0.0867
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0146	0.0572	0.0656
Entamoeba histolytica	hypothetical protein	0.0027	0.0042	0.0013
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1914	0.8469	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0123	0.0471	0.0522
Loa Loa (eye worm)	phosphatidylinositol 3	0.0123	0.0471	0.0536
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0082	0.0097
Loa Loa (eye worm)	phosphatidylinositol 3	0.0123	0.0471	0.0536
Echinococcus multilocularis	voltage dependent calcium channel	0.0146	0.0572	0.0572
Echinococcus multilocularis	snurportin 1	0.036	0.1526	0.1526
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0082	0.0082
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0403	0.1721	0.2706
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0471	0.0522
Echinococcus granulosus	transient receptor potential cation channel	0.0146	0.0572	0.0572
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0146	0.0572	0.0572
Echinococcus granulosus	cpg binding protein	0.0071	0.0237	0.0237
Loa Loa (eye worm)	phosphatidylinositol 3	0.0123	0.0471	0.0536
Schistosoma mansoni	hypothetical protein	0.0198	0.0804	0.0949
Brugia malayi	CXXC zinc finger family protein	0.0067	0.022	0.024
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0146	0.0572	0.0656
Echinococcus multilocularis	transient receptor potential gamma protein	0.0146	0.0572	0.0572
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0146	0.0572	0.0675
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1914	0.8469	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.0031	0.0031
Brugia malayi	hypothetical protein	0.0042	0.0108	0.0107
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0123	0.0471	0.5
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Echinococcus multilocularis	Zinc finger, PHD finger	0.0123	0.0471	0.0471
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1914	0.8469	0.8464
Schistosoma mansoni	cpg binding protein	0.0071	0.0237	0.0279
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0123	0.0471	0.0442
Schistosoma mansoni	ran	0.0025	0.0031	0.0036
Echinococcus granulosus	hyperpolarization activated cyclic	0.0146	0.0572	0.0572
Echinococcus multilocularis	voltage gated potassium channel	0.0146	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1914	0.8469	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0123	0.0471	0.0522
Schistosoma mansoni	ryanodine receptor related	0.0146	0.0572	0.0675
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0123	0.0471	0.0706
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0362	0.1537	0.1785
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0123	0.0471	0.0536
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0123	0.0471	0.0522
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1522	0.672	0.7927
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0123	0.0471	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0123	0.0471	0.0442
Entamoeba histolytica	hypothetical protein	0.0042	0.0108	0.0091
Schistosoma mansoni	importin beta-1	0.0034	0.007	0.0083
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0146	0.0572	0.0642
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Echinococcus granulosus	hyperpolarization activated cyclic	0.0146	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0146	0.0572	0.0572
Schistosoma mansoni	calcium-activated potassium channel	0.0146	0.0572	0.0675
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0123	0.0471	0.0522
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0123	0.0471	0.0471
Echinococcus multilocularis	short transient receptor potential channel 6	0.0146	0.0572	0.0572
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0146	0.0572	0.0572
Schistosoma mansoni	hypothetical protein	0.0042	0.0108	0.0127
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.028	0.117	0.117
Leishmania major	hypothetical protein, conserved	0.0123	0.0471	0.0442
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0123	0.0471	0.0522
Loa Loa (eye worm)	voltage-gated potassium channel	0.0146	0.0572	0.0655
Schistosoma mansoni	vesicular amine transporter	0.0146	0.0572	0.0675
Echinococcus multilocularis	potassium voltage gated channel protein	0.0146	0.0572	0.0572
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1914	0.8469	0.8464
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0108	0.0127
Leishmania major	phosphatidylinositol kinase, putative	0.0123	0.0471	0.0442
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	0.0522
Echinococcus granulosus	snurportin 1	0.036	0.1526	0.1526
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0123	0.0471	0.0522
Schistosoma mansoni	voltage-gated ion channel	0.0146	0.0572	0.0675
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0123	0.0471	0.0522
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0146	0.0572	0.0572
Schistosoma mansoni	transient receptor potential channel	0.0146	0.0572	0.0675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0642	0.2787	0.3266
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0123	0.0471	0.0557
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0022	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0362	0.1537	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0572	0.0655
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0123	0.0471	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0123	0.0471	0.0557
Echinococcus granulosus	potassium large conductance calcium activated	0.0146	0.0572	0.0572
Echinococcus multilocularis	transient receptor potential cation channel	0.0146	0.0572	0.0572
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0146	0.0572	0.0675
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.2257	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0082	0.0082
Schistosoma mansoni	voltage-gated potassium channel	0.0146	0.0572	0.0675
Onchocerca volvulus		0.0146	0.0572	0.4533
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.4529	0.5331
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0146	0.0572	0.0675
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0642	0.2787	0.3291
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0146	0.0572	0.0572
Echinococcus granulosus	voltage dependent calcium channel	0.0146	0.0572	0.0572
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0108	0.0108
Echinococcus granulosus	voltage dependent calcium channel	0.0146	0.0572	0.0572
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0144	0.0561	0.0663
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0123	0.0471	0.0538
Plasmodium vivax	importin-beta 2, putative	0.0034	0.007	0.0901
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0146	0.0572	0.0572
Echinococcus granulosus	sodium leak channel non selective protein	0.0146	0.0572	0.0572
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0123	0.0471	0.0706
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0123	0.0471	0.0706
Brugia malayi	voltage-dependent calcium channel	0.0146	0.0572	0.0656
Echinococcus granulosus	transient receptor potential cation channel	0.0146	0.0572	0.0572
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0123	0.0471	0.0471
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.036	0.1526	0.1784
Echinococcus granulosus	short transient receptor potential channel 6	0.0146	0.0572	0.0572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0642	0.2787	0.3266
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0146	0.0572	0.0675
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0146	0.0572	0.0656
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1914	0.8469	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= 20.8 %	Compound was evaluated for the antinociceptive effects at the dose 0.025(mg/kg)	ChEMBL.	1507202
Change (functional)	= 20.8 %	Compound was evaluated for the antinociceptive effects at the dose 0.025(mg/kg)	ChEMBL.	1507202
Change (functional)	= 28.4 %	Compound was evaluated for the antinociceptive effects at the dose 1.0(mg/kg)	ChEMBL.	1507202
Change (functional)	= 28.4 %	Compound was evaluated for the antinociceptive effects at the dose 1.0(mg/kg)	ChEMBL.	1507202
Change (functional)	= 33.4 %	Compound was evaluated for the antinociceptive effects at the dose 0.25(mg/kg)	ChEMBL.	1507202
Change (functional)	= 33.4 %	Compound was evaluated for the antinociceptive effects at the dose 0.25(mg/kg)	ChEMBL.	1507202
Change (functional)	= 34 %	Compound was evaluated for the antinociceptive effects at the dose 0.5(mg/kg)	ChEMBL.	1507202
Change (functional)	= 34 %	Compound was evaluated for the antinociceptive effects at the dose 0.5(mg/kg)	ChEMBL.	1507202
Change (functional)	= 68.3 %	Compound was evaluated for the antinociceptive effects at the dose 0.1(mg/kg)	ChEMBL.	1507202
Change (functional)	= 68.3 %	Compound was evaluated for the antinociceptive effects at the dose 0.1(mg/kg)	ChEMBL.	1507202
Change (functional)	= 85 %	Compound was evaluated for the antinociceptive effects at the dose 0.05(mg/kg)	ChEMBL.	1507202
Change (functional)	= 85 %	Compound was evaluated for the antinociceptive effects at the dose 0.05(mg/kg)	ChEMBL.	1507202
EC50 (functional)	= 116.2 nM	Effective concentration for inhibition of human Cannabinoid receptor 2-mediated adenylylcyclase using African green monkey (COS-7) cells transfected with the cDNA of human CB2 receptor	ChEMBL.	9379442
EC50 (functional)	= 116.2 nM	Effective concentration for inhibition of human Cannabinoid receptor 2-mediated adenylylcyclase using African green monkey (COS-7) cells transfected with the cDNA of human CB2 receptor	ChEMBL.	9379442
EC50 (functional)	= 927 nM	Effective concentration for inhibition of Cannabinoid receptor 1-mediated adenylylcyclase activity using African green monkey (COS-7) cells transfected with the cDNA of rat CB1 receptor	ChEMBL.	9379442
EC50 (functional)	= 927 nM	Effective concentration for inhibition of Cannabinoid receptor 1-mediated adenylylcyclase activity using African green monkey (COS-7) cells transfected with the cDNA of rat CB1 receptor	ChEMBL.	9379442
Inhibition (functional)	= 26.3 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.05(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 26.3 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.05(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 52.6 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.1(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 52.6 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.1(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 56.4 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.25(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 56.4 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.25(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 73.7 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.5(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 73.7 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.5(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 97.4 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.5(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 97.4 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.5(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 100 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.5(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 100 %	Compound was evaluated for the percent inhibition of arachidonic acid-induced paw edema at the dose 0.5(mg/kg)	ChEMBL.	1507202
Inhibition (functional)	= 101 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.05 (mg/kg) (Increases in paw volume is -1.2 uL)	ChEMBL.	1507202
Inhibition (functional)	= 101 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.05 (mg/kg) (Increases in paw volume is -1.2 uL)	ChEMBL.	1507202
Inhibition (functional)	= 135 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.1 (mg/kg) (Increases in paw volume is -10 uL)	ChEMBL.	1507202
Inhibition (functional)	= 135 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.1 (mg/kg) (Increases in paw volume is -10 uL)	ChEMBL.	1507202
Inhibition (functional)	= 150 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.25 (mg/kg) (Increases in paw volume is -14 uL)	ChEMBL.	1507202
Inhibition (functional)	= 150 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.25 (mg/kg) (Increases in paw volume is -14 uL)	ChEMBL.	1507202
Inhibition (functional)	= 171 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.5 (mg/kg) (Increases in paw volume is -20 uL)	ChEMBL.	1507202
Inhibition (functional)	= 171 %	Compound was evaluated for the percent inhibition of PAF-induced Paw edema at the dose 0.5 (mg/kg) (Increases in paw volume is -20 uL)	ChEMBL.	1507202
Ki (binding)	= 32.3 nM	Binding to Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat CB1.	ChEMBL.	9379442
Ki (binding)	= 32.3 nM	Binding to Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat CB1.	ChEMBL.	9379442
Ki (binding)	= 170.5 nM	Binding affinity to Cannabinoid receptor 2 using African green monkey (COS-7) cells Chinese hamster ovary(CHO) cells transfected with the cDNA of human CB2	ChEMBL.	9379442
Ki (binding)	= 170.5 nM	Binding affinity to Cannabinoid receptor 2 using African green monkey (COS-7) cells Chinese hamster ovary(CHO) cells transfected with the cDNA of human CB2	ChEMBL.	9379442
Ki (binding)	= 480.6 nM	Binding affinity for Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat brain synaptosomal membrane preparations.	ChEMBL.	9379442
Ki (binding)	= 480.6 nM	Binding affinity for Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat brain synaptosomal membrane preparations.	ChEMBL.	9379442
No. of cells (functional)	= 0.3	Compound was evaluated for the effect on leukocyte adhesion at the dose 1.0 (mg/kg) ;oral administration	ChEMBL.	1507202
No. of cells (functional)	= 0.64	Compound was evaluated for the effect on leukocyte adhesion at the dose 0.1 (mg/kg) ;oral administration	ChEMBL.	1507202
No. of cells (functional)	= 0.87	Compound was evaluated for the effect on leukocyte adhesion at the dose 0.5 (mg/kg) ;oral administration	ChEMBL.	1507202
No. of cells (functional)	= 0.88	Compound was evaluated for the effect on leukocyte adhesion at the dose 0.01 (mg/kg) ;oral administration	ChEMBL.	1507202
No. of cells (functional)	= 1.34	Compound was evaluated for the effect on leukocyte adhesion at the dose 0.05 (mg/kg) ;oral administration	ChEMBL.	1507202
Response (functional)	= 5.8	Compound was evaluated for the cataleptic effect in the mouse at the dose 0.1(mg/kg)	ChEMBL.	1507202
Response (functional)	= 12.2	Compound was evaluated for the cataleptic effect in the mouse at the dose 1.0(mg/kg)	ChEMBL.	1507202

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL320408

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 176154