Detailed information for compound 177525

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 540.696 | Formula: C33H40N4O3
  • H donors: 4 H acceptors: 2 LogP: 4.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCC(=N)NCCc1ccc2c(c1)c1C[C@@]3(O)C4Cc5c6[C@]3([C@H](c1[nH]2)Oc6c(O)cc5)CCN4CC1CC1
  • InChi: 1S/C33H40N4O3/c1-2-3-4-27(34)35-13-11-19-7-9-24-22(15-19)23-17-33(39)26-16-21-8-10-25(38)30-28(21)32(33,31(40-30)29(23)36-24)12-14-37(26)18-20-5-6-20/h7-10,15,20,26,31,36,38-39H,2-6,11-14,16-18H2,1H3,(H2,34,35)/t26?,31-,32-,33+/m0/s1
  • InChiKey: UAIUAJRUOCAUGH-NHTBSUTASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica serine/threonine kinase, putative 0.0417 0.2081 0.4029
Plasmodium vivax tyrosine kinase-like protein, putative 0.0417 0.2081 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0417 0.2081 0.2081
Echinococcus multilocularis tensin 0.0594 0.2995 0.2995
Brugia malayi jmjC domain containing protein 0.0038 0.0123 0.0238
Echinococcus multilocularis activated cdc42 kinase 1 0.0417 0.2081 0.2081
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Brugia malayi hypothetical protein 0.0417 0.2081 0.4042
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0131 0.0602 0.0602
Echinococcus granulosus ephrin type A receptor 4 A 0.0417 0.2081 0.2081
Brugia malayi Protein kinase domain containing protein 0.1011 0.5147 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0417 0.2081 0.4042
Schistosoma mansoni shc transforming protein 0.0594 0.2995 0.2995
Onchocerca volvulus 0.1011 0.5147 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0143 0.0665 0.1291
Loa Loa (eye worm) hypothetical protein 0.0033 0.01 0.0194
Schistosoma mansoni hypothetical protein 0.0043 0.0153 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0012 0.061
Onchocerca volvulus Tyrosine kinase homolog 0.0417 0.2081 0.3973
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0417 0.2081 0.2081
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0073
Trypanosoma cruzi polo-like protein kinase, putative 0.0079 0.0337 0.1618
Entamoeba histolytica serine/threonine kinase, putative 0.0417 0.2081 0.4029
Onchocerca volvulus 0.0594 0.2995 0.577
Brugia malayi Tyrosine-protein kinase abl-1 0.1011 0.5147 1
Echinococcus multilocularis epidermal growth factor receptor 0.0417 0.2081 0.2081
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.005 0.0237
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0594 0.2995 0.5818
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0636 0.3209 0.3209
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.005
Echinococcus granulosus epidermal growth factor receptor 0.0417 0.2081 0.2081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0151
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1011 0.5147 0.5147
Echinococcus granulosus tyrosine protein kinase ABL1 0.1011 0.5147 0.5147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0131 0.0602 0.0602
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Brugia malayi Variant SH3 domain containing protein 0.0594 0.2995 0.5818
Brugia malayi PHD-finger family protein 0.0031 0.0089 0.0172
Onchocerca volvulus 0.0594 0.2995 0.577
Echinococcus granulosus NCK adaptor protein 0.0594 0.2995 0.2995
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0131 0.0602 0.0602
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0089 0.0426
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0401 0.8837
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0417 0.2082 0.2082
Echinococcus granulosus SH2 motif 0.0594 0.2995 0.2995
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.1231 0.1231
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0252 0.1231 0.2391
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Echinococcus granulosus lamin dm0 0.0029 0.0077 0.0077
Brugia malayi C-terminal src kinase protein 1 0.0417 0.2081 0.4042
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0059 0.0114
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0077 0.0149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.01 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0161 0.0313
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0136 0.0136
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0417 0.2081 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0586 0.1138
Brugia malayi integrin-linked kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) SRC-1 0.1011 0.5147 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1011 0.5147 1
Trypanosoma brucei polo-like protein kinase 0.0079 0.0337 0.1618
Giardia lamblia Kinase, PLK 0.0079 0.0337 0.1619
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0092 0.044
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0059 0.0282
Schistosoma mansoni protein tyrosine kinase 0.0417 0.2081 0.208
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0201 0.0201
Leishmania major protein kinase, putative 0.0417 0.2082 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0079 0.0337 0.0633
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0136 0.0264
Echinococcus granulosus activin receptor type 0.0417 0.2082 0.2082
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0147 0.0286
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1011 0.5147 0.5147
Echinococcus granulosus SHC transforming protein 3 0.0594 0.2995 0.2995
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0417 0.2081 0.9994
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0237
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0015 0.0334
Brugia malayi SH2 domain containing protein 0.0594 0.2995 0.5818
Plasmodium vivax protein kinase, putative 0.0417 0.2081 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0059 0.3075
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0417 0.2081 0.2081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0147 0.0286
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0015 0.003
Schistosoma mansoni hypothetical protein 0.0594 0.2995 0.2995
Trypanosoma brucei glucosidase, putative 0.0032 0.0092 0.044
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0015 0.0015
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Echinococcus multilocularis tyrosine protein kinase csk 0.0417 0.2081 0.2081
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0337 0.1619
Echinococcus multilocularis chromobox protein 1 0.0059 0.0234 0.0234
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Trypanosoma cruzi protein kinase, putative 0.0417 0.2081 0.9994
Entamoeba histolytica hypothetical protein 0.0038 0.0126 0.0223
Schistosoma mansoni alpha glucosidase 0.0032 0.0092 0.0092
Onchocerca volvulus 0.0161 0.076 0.1379
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0417 0.2081 0.9994
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0092 0.0178
Echinococcus granulosus lamin 0.0029 0.0077 0.0077
Echinococcus granulosus retinal guanylyl cyclase 2 0.0417 0.2081 0.2081
Entamoeba histolytica receptor protein kinase, putative 0.0417 0.2081 0.4029
Loa Loa (eye worm) serine/threonine protein kinase 0.0417 0.2081 0.4042
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0417 0.2081 0.2081
Onchocerca volvulus 0.0026 0.0063 0.0007
Schistosoma mansoni tyrosine kinase 0.1011 0.5147 0.5147
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Onchocerca volvulus 0.0029 0.0077 0.0035
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0417 0.2081 1
Brugia malayi Raf kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0012 0.0056
Schistosoma mansoni alpha-glucosidase 0.0123 0.0562 0.0562
Schistosoma mansoni lamin 0.0029 0.0077 0.0077
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0092 0.044
Brugia malayi Glycosyl hydrolases family 31 protein 0.0143 0.0665 0.1291
Loa Loa (eye worm) TK/DDR protein kinase 0.0417 0.2081 0.4042
Plasmodium falciparum protein kinase, putative 0.0417 0.2081 0.9994
Echinococcus multilocularis growth factor receptor bound protein 2 0.0594 0.2995 0.2995
Echinococcus multilocularis lamin dm0 0.0029 0.0077 0.0077
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Loa Loa (eye worm) TK/Met protein kinase 0.0417 0.2081 0.4042
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0152 0.0152
Entamoeba histolytica ankyrin repeat protein 0.0417 0.2081 0.4029
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Entamoeba histolytica serine/threonine kinase, putative 0.0417 0.2081 0.4029
Brugia malayi glutathione reductase 0.004 0.0136 0.0263
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0073
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0417 0.2081 0.4042
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0092 0.044
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0594 0.2995 0.2995
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0012 0.0257
Echinococcus granulosus tyrosine protein kinase Src42A 0.1011 0.5147 0.5147
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0059 0.3075
Echinococcus granulosus tyrosine protein kinase Lyn 0.1011 0.5148 0.5148
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0194 0.0376
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0021 0.0449
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0594 0.2995 0.2995
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.1011 0.5147 0.5147
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Loa Loa (eye worm) hypothetical protein 0.0153 0.072 0.1399
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.2081 1
Schistosoma mansoni adapter molecule crk 0.0594 0.2995 0.2995
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.2081 1
Echinococcus multilocularis SHC transforming protein 3 0.0594 0.2995 0.2995
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.026 0.0505
Schistosoma mansoni alpha-glucosidase 0.0123 0.0562 0.0562
Toxoplasma gondii thioredoxin reductase 0.004 0.0136 0.0651
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0079 0.0337 0.1618
Echinococcus multilocularis tumor protein p63 0.0361 0.1789 0.1789
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Schistosoma mansoni tyrosine kinase 0.1011 0.5147 0.5147
Schistosoma mansoni growth factor receptor-bound protein 0.0594 0.2995 0.2995
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0131 0.0602 0.117
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.005 0.0237
Brugia malayi Variant SH3 domain containing protein 0.0594 0.2995 0.5818
Brugia malayi SH2 domain containing protein 0.0594 0.2995 0.5818
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2082 0.4031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0131 0.0602 0.0602
Onchocerca volvulus 0.1011 0.5147 1
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0092 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.2081 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0401 0.8837
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0149
Echinococcus granulosus insulin receptor 0.0417 0.2081 0.2081
Loa Loa (eye worm) hypothetical protein 0.0161 0.076 0.1478
Schistosoma mansoni hypothetical protein 0.0043 0.0153 0.0152
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Echinococcus multilocularis signal transduction protein lnk realted 0.0594 0.2995 0.2995
Loa Loa (eye worm) TK/FER protein kinase 0.0417 0.2081 0.4042
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Trypanosoma cruzi protein kinase, putative 0.0417 0.2081 0.9994
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0092 0.0178
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0113 0.054
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0417 0.2081 0.208
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1011 0.5147 0.5147
Echinococcus granulosus receptor type guanylyl cyclase 0.0417 0.2081 0.2081
Schistosoma mansoni hypothetical protein 0.0594 0.2995 0.2995
Loa Loa (eye worm) RGC/RGC protein kinase 0.0417 0.2081 0.4042
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0089 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0417 0.2081 1
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus granulosus protein tyrosine kinase 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0594 0.2995 0.2995
Brugia malayi SH2 domain containing protein 0.0594 0.2995 0.5818
Onchocerca volvulus 0.1011 0.5147 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0454 0.0454
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0123 0.0238
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0064 0.0309
Loa Loa (eye worm) SH2 domain-containing protein 0.0594 0.2995 0.5818
Brugia malayi Furin-like cysteine rich region family protein 0.0417 0.2081 0.4042
Entamoeba histolytica serine/threonine kinase, putative 0.0417 0.2081 0.4029
Echinococcus multilocularis tyrosine protein kinase Abl 0.1011 0.5147 0.5147
Trichomonas vaginalis STE family protein kinase 0.0417 0.2081 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0401 0.8837
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0417 0.2081 0.2081
Brugia malayi SH2 domain containing protein 0.0594 0.2995 0.5818
Onchocerca volvulus 0.0083 0.0354 0.058
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0594 0.2995 0.2995
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0417 0.2081 0.2081
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0594 0.2995 0.5818
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0089 0.0173
Echinococcus multilocularis integrin linked protein kinase 0.0417 0.2081 0.2081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0191 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.0665 0.0665
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0417 0.2081 0.4042
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Echinococcus multilocularis tyrosine protein kinase csk 0.0417 0.2081 0.2081
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Echinococcus granulosus epidermal growth factor receptor 0.0417 0.2081 0.2081
Echinococcus multilocularis NCK adaptor protein 0.0594 0.2995 0.2995
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0594 0.2995 0.2995
Echinococcus granulosus tensin 0.0594 0.2995 0.2995
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0059 0.3075
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Onchocerca volvulus 0.0417 0.2081 0.3973
Loa Loa (eye worm) TK/FER protein kinase 0.0417 0.2081 0.4042
Entamoeba histolytica protein kinase, putative 0.0594 0.2996 0.5811
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0077 0.0149
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0417 0.2081 0.2081
Echinococcus granulosus lysosomal alpha glucosidase 0.0143 0.0665 0.0665
Brugia malayi chromobox protein homolog 3 0.0033 0.01 0.0193
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0122 0.0585
Echinococcus granulosus dna polymerase kappa 0.0016 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0417 0.2082 1
Loa Loa (eye worm) hypothetical protein 0.1011 0.5147 1
Trichomonas vaginalis protein kinase atn1, putative 0.0417 0.2081 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0079 0.0337 0.0655
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0417 0.2081 0.2081
Onchocerca volvulus 0.0417 0.2081 0.3973
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Echinococcus granulosus tar DNA binding protein 0.0113 0.0512 0.0512
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Brugia malayi Sex muscle abnormal protein 5 0.0594 0.2995 0.5818
Loa Loa (eye worm) TK/FER protein kinase 0.0417 0.2081 0.4042
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Trichomonas vaginalis TK family protein kinase 0.0417 0.2081 1
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Giardia lamblia Kinase 0.0417 0.2081 1
Trichomonas vaginalis AGC family protein kinase 0.0417 0.2081 1
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0012 0.0012
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0417 0.2081 1
Onchocerca volvulus 0.0417 0.2081 0.3973
Brugia malayi hypothetical protein 0.0038 0.0126 0.0245
Schistosoma mansoni kinase 0.004 0.0136 0.0136
Entamoeba histolytica hypothetical protein, conserved 0.0417 0.2081 0.4029
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0594 0.2995 0.2995
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0015 0.0073
Echinococcus granulosus activated cdc42 kinase 1 0.0417 0.2081 0.2081
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0417 0.2081 0.4042
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0012 0.0056
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0594 0.2995 0.2995
Entamoeba histolytica tyrosin kinase, putative 0.0417 0.2081 0.4029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0417 0.2081 0.4042
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0059 0.3075
Schistosoma mansoni patched 1 0.0045 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0126 0.0126
Loa Loa (eye worm) TK/EPH protein kinase 0.0417 0.2081 0.4042
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Echinococcus granulosus tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0136 0.0136
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0173
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0417 0.2081 0.208
Brugia malayi Heterochromatin protein 1 0.0059 0.0234 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.2081 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0417 0.2081 0.4029
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0079 0.0337 0.0337
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0161 0.0161
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0012 0.0012
Giardia lamblia DINP protein human, muc B family 0.0016 0.0012 0.0056
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1011 0.5147 0.5147
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Brugia malayi Thioredoxin reductase 0.004 0.0136 0.0263
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trypanosoma brucei unspecified product 0.0016 0.0012 0.0056
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0417 0.2081 0.2081
Loa Loa (eye worm) hypothetical protein 0.0053 0.0204 0.0396
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0123 0.0123
Echinococcus granulosus dna polymerase eta 0.0038 0.0122 0.0122
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.0665 0.0665
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0012 0.0056
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Entamoeba histolytica receptor protein kinase, putative 0.0417 0.2081 0.4029
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0161 0.0773
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0073
Echinococcus multilocularis tyrosine kinase 0.1011 0.5147 0.5147
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0089 0.0426
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0594 0.2995 0.5818
Entamoeba histolytica tyrosin kinase, putative 0.0417 0.2081 0.4029
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Schistosoma mansoni hypothetical protein 0.0043 0.0153 0.0152
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0092 0.0092
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.01 0.0478
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0012 0.0012
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0594 0.2995 0.2995
Echinococcus multilocularis peregrin 0.0031 0.0089 0.0089
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.2081 1
Brugia malayi Protein kinase domain containing protein 0.1011 0.5147 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) TK/ROR protein kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Schistosoma mansoni vav2 0.0594 0.2995 0.2995
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0337 0.1619
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0417 0.2081 0.208
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Schistosoma mansoni nck2/grb4 0.0594 0.2995 0.2995
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0131 0.0602 0.0602
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0337 0.1619
Schistosoma mansoni protein kinase 0.0417 0.2082 0.2082
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0092 0.044
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0114
Echinococcus granulosus tyrosine protein kinase csk 0.0417 0.2081 0.2081
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.0703 0.0703
Onchocerca volvulus 0.0594 0.2995 0.577
Echinococcus multilocularis protein dispatched 1 0.0051 0.0194 0.0194
Echinococcus granulosus SH2 domain containing protein 7 0.0594 0.2995 0.2995
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Echinococcus multilocularis transfer RNA-Thr 0.0417 0.2081 0.2081
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Echinococcus granulosus tyrosine protein kinase Blk 0.1011 0.5147 0.5147
Onchocerca volvulus 0.0417 0.2081 0.3973
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0454 1
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0417 0.2081 0.4029
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0471 0.0893
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0417 0.2081 0.4042
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0092 0.0092
Brugia malayi SH2 domain containing protein 0.1011 0.5147 1
Echinococcus granulosus c src tyrosine kinase 0.1011 0.5147 0.5147
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0059 0.0114
Schistosoma mansoni tensin 0.0594 0.2995 0.2995
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0417 0.2082 0.2082
Schistosoma mansoni serine/threonine RGC 0.0417 0.2081 0.208
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Leishmania major protein kinase, putative 0.0417 0.2081 0.9994
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0594 0.2995 0.2995
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0012 0.0023
Echinococcus granulosus intermediate filament protein 0.0029 0.0077 0.0077
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni tensin 0.0594 0.2995 0.2995
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Brugia malayi SH2 domain containing protein 0.1011 0.5147 1
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Entamoeba histolytica cysteine surface protein, putative 0.0417 0.2081 0.4029
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0512 0.0512
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0594 0.2995 0.2995
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.2081 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.0191 0.0191
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0417 0.2081 0.2081
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Echinococcus granulosus tyrosine protein kinase csk 0.0417 0.2081 0.2081
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0131 0.0627
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0234 0.1123
Brugia malayi hypothetical protein 0.0252 0.1231 0.2391
Echinococcus multilocularis raf serine:threonine protein kinase 0.0417 0.2081 0.2081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0126 0.0126
Brugia malayi serine/threonine-protein kinase plk-2 0.0079 0.0337 0.0655
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0122
Echinococcus granulosus tyrosine protein kinase csk 0.0417 0.2081 0.2081
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0417 0.2081 0.2081
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0234 0.1123
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0471 0.0471
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0012 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Loa Loa (eye worm) RGC/RGC protein kinase 0.0417 0.2081 0.4042
Brugia malayi SH2 domain containing protein 0.0594 0.2995 0.5818
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0059 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0337 0.1619
Echinococcus granulosus suppressor of cytokine signaling 6 0.0594 0.2995 0.2995
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0131 0.0602 0.0602
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0012 0.0056
Schistosoma mansoni microtubule-associated protein tau 0.1951 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.0191 0.0917
Echinococcus multilocularis SH2 motif 0.0594 0.2995 0.2995
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Plasmodium falciparum thioredoxin reductase 0.004 0.0136 0.0651
Echinococcus granulosus retinal guanylyl cyclase 2 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Brugia malayi Protein kinase domain containing protein 0.1011 0.5147 1
Schistosoma mansoni hypothetical protein 0.0043 0.0153 0.0152
Echinococcus granulosus kinase suppressor of Ras 1 0.0417 0.2081 0.2081
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0059 0.1293
Echinococcus multilocularis geminin 0.0181 0.0861 0.0861
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0015
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0401 0.8837
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0594 0.2995 0.5818
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Leishmania major hypothetical protein, conserved 0.0417 0.2081 0.9994
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0113 0.0106
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0012 0.0012
Brugia malayi N-terminal motif family protein 0.0153 0.072 0.1399
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Onchocerca volvulus 0.0029 0.0077 0.0035
Loa Loa (eye worm) protein kinase domain-containing protein 0.0417 0.2081 0.4042
Brugia malayi protein-tyrosine kinase 0.1011 0.5147 1
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0471 0.0471
Onchocerca volvulus 0.1011 0.5147 1
Brugia malayi Protein kinase domain containing protein 0.1011 0.5147 1
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0161 0.0161
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0594 0.2995 0.5818
Echinococcus granulosus tyrosine protein kinase 0.0417 0.2081 0.2081
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.2081 0.208
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Onchocerca volvulus 0.0417 0.2081 0.3973
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0021 0.0449
Schistosoma mansoni signal transduction protein lnk-related 0.0594 0.2995 0.2995
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Loa Loa (eye worm) heterochromatin protein 1 0.0059 0.0234 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0123 0.0123
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0092 0.0156
Echinococcus granulosus tyrosine kinase 0.1011 0.5147 0.5147
Entamoeba histolytica ankyrin repeat protein 0.0417 0.2081 0.4029
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0092 0.044
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1011 0.5147 0.5147
Mycobacterium ulcerans hypothetical protein 0.0025 0.0059 0.3075
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0594 0.2995 0.577
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Trichomonas vaginalis protein tyrosine kinase, putative 0.0417 0.2081 1
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0337 0.1619
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Onchocerca volvulus 0.0053 0.0201 0.0279
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Onchocerca volvulus 0.1011 0.5147 1
Echinococcus multilocularis SH2 motif 0.0594 0.2995 0.2995
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0417 0.2081 0.208
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.0191 0.4205
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0147 0.0285
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Schistosoma mansoni GTPase activating protein 0.0594 0.2995 0.2995
Brugia malayi Receptor family ligand binding region containing protein 0.0417 0.2081 0.4042
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0026 0.1346
Brugia malayi hypothetical protein 0.0594 0.2995 0.5818
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0026 1
Trypanosoma brucei trypanothione reductase 0.004 0.0136 0.0651
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.0454 1
Brugia malayi SH2 domain containing protein 0.0594 0.2995 0.5818
Entamoeba histolytica serine/threonine kinase, putative 0.0417 0.2081 0.4029
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0417 0.2081 0.3973
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Schistosoma mansoni lamin 0.0029 0.0077 0.0077
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0191 0.0191
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0059 0.1293
Loa Loa (eye worm) glutathione reductase 0.004 0.0136 0.0264
Schistosoma mansoni protein kinase 0.0417 0.2082 0.2082
Loa Loa (eye worm) STAT protein 0.0594 0.2995 0.5818
Brugia malayi Bromodomain containing protein 0.0031 0.0089 0.0172
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0092 0.044
Echinococcus multilocularis musashi 0.0029 0.0077 0.0077
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0471 0.0914
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.005
Echinococcus multilocularis tyrosine protein kinase Srms 0.1011 0.5147 0.5147
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0123 0.0122
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus granulosus N chimaerin 0.0594 0.2995 0.2995
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0594 0.2995 0.2995
Loa Loa (eye worm) TK/RYK protein kinase 0.0417 0.2081 0.4042
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Onchocerca volvulus Alhambra homolog 0.0031 0.0089 0.0059
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0417 0.2081 0.2081
Schistosoma mansoni SH2A 0.0594 0.2995 0.2995
Plasmodium falciparum protein kinase, putative 0.0417 0.2081 0.9994
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0114
Echinococcus multilocularis microtubule associated protein 2 0.1951 1 1
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0512 0.0512
Echinococcus multilocularis ephrin type A receptor 4 A 0.0417 0.2081 0.2081
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Echinococcus granulosus growth factor receptor bound protein 2 0.0594 0.2995 0.2995
Loa Loa (eye worm) hypothetical protein 0.0105 0.0471 0.0914
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0131 0.0602 0.1169
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Brugia malayi ephrin receptor 1 precursor 0.0417 0.2081 0.4042
Schistosoma mansoni hypothetical protein 0.0181 0.0861 0.0861
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) TK/FER protein kinase 0.0417 0.2081 0.4042
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0594 0.2995 0.2995
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0059 0.0282
Toxoplasma gondii protein kinase domain-containing protein 0.0417 0.2081 0.9994
Trypanosoma brucei Pseudokinase, putative 0.0417 0.2081 0.9994
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0417 0.2081 1
Schistosoma mansoni tyrosine kinase 0.1011 0.5147 0.5147
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0401 0.8837
Entamoeba histolytica tyrosin kinase, putative 0.0417 0.2081 0.4029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.0015
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0092 0.0156
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.0191 0.0917
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0191 0.0191
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0417 0.2081 0.2081
Echinococcus granulosus natriuretic peptide receptor 1 0.0417 0.2081 0.2081
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Leishmania major DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Schistosoma mansoni tensin 0.0594 0.2995 0.2995
Schistosoma mansoni tensin-related 0.0594 0.2995 0.2995
Schistosoma mansoni tyrosine kinase 0.1011 0.5147 0.5147
Loa Loa (eye worm) hypothetical protein 0.0055 0.0213 0.0415
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0008 0.0015
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0153 0.072 0.1299
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Schistosoma mansoni hypothetical protein 0.0181 0.0861 0.0861
Brugia malayi bone morphogenetic protein type 1 receptor 0.0417 0.2081 0.4042
Echinococcus granulosus tyrosine protein kinase HCK 0.0417 0.2081 0.2081
Echinococcus granulosus peregrin 0.0031 0.0089 0.0089
Echinococcus granulosus raf serine:threonine protein kinase 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0417 0.2081 0.4042
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0417 0.2081 0.2081
Brugia malayi RhoGAP domain containing protein 0.0594 0.2995 0.5818
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0417 0.2081 0.208
Brugia malayi Immunoglobulin I-set domain containing protein 0.0417 0.2081 0.4042
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0417 0.2081 0.2081
Schistosoma mansoni suppressor of cytokine signaling 0.0594 0.2995 0.2995
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0059 0.3075
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1011 0.5147 0.5147
Echinococcus granulosus expressed conserved protein 0.0099 0.0438 0.0438
Echinococcus granulosus neuropeptide s receptor 0.0396 0.1974 0.1974
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0012 0.0056
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0077 0.0149
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0417 0.2081 0.2081
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Echinococcus granulosus tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Echinococcus multilocularis tyrosine protein kinase pr2 0.0417 0.2081 0.2081
Brugia malayi Variant SH3 domain containing protein 0.0594 0.2995 0.5818
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0417 0.2081 0.2081
Entamoeba histolytica SH2 domain containing protein 0.0594 0.2995 0.5809
Loa Loa (eye worm) TK/ALK protein kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) TAR-binding protein 0.0113 0.0512 0.0996
Echinococcus granulosus retinal guanylyl cyclase 2 0.0417 0.2081 0.2081
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0417 0.2081 0.2081
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0079 0.0337 0.0337
Brugia malayi jmjC domain containing protein 0.0102 0.0454 0.0882
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0594 0.2995 0.5818
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0059 0.0092
Onchocerca volvulus 0.0417 0.2081 0.3973
Echinococcus granulosus geminin 0.0181 0.0861 0.0861
Echinococcus multilocularis protein tyrosine kinase 0.0417 0.2081 0.2081
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.039
Echinococcus granulosus tyrosine protein kinase Src42A 0.0594 0.2995 0.2995
Loa Loa (eye worm) TK/FER protein kinase 0.0417 0.2081 0.4042
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Entamoeba histolytica tyrosin kinase, putative 0.0417 0.2081 0.4029
Echinococcus granulosus tyrosine kinase 0.1011 0.5147 0.5147
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0454 0.0454
Brugia malayi SRC-1 0.1011 0.5147 1
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0586 0.1138
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.2081 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1011 0.5147 0.5147
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0479 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Schistosoma mansoni intermediate filament proteins 0.0029 0.0077 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0512 0.0512
Echinococcus granulosus signal transduction protein lnk realted 0.0594 0.2995 0.2995
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0015
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0512 0.0512
Echinococcus multilocularis tyrosine protein kinase HCK 0.0417 0.2081 0.2081
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.2081 0.208
Loa Loa (eye worm) TK/ABL protein kinase 0.1011 0.5147 1
Onchocerca volvulus 0.0417 0.2081 0.3973
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0059 0.0282
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0401 0.8665
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Brugia malayi Guanylyl cyclase protein 23 0.0417 0.2081 0.4042
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0015 0.0073
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Brugia malayi hypothetical protein 0.0417 0.2081 0.4042
Echinococcus granulosus suppressor of cytokine signaling 7 0.0594 0.2995 0.2995
Leishmania major trypanothione reductase 0.004 0.0136 0.0651
Brugia malayi Tyrosine-protein kinase PR2 0.0417 0.2081 0.4042
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Brugia malayi Variant SH3 domain containing protein 0.0594 0.2995 0.5818
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Echinococcus granulosus hypothetical protein 0.0594 0.2995 0.2995
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Schistosoma mansoni hypothetical protein 0.0051 0.0194 0.0194
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0417 0.2081 0.4042
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0012 0.061
Onchocerca volvulus 0.0051 0.0194 0.0265
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0123 0.0122
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0136 0.2985
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica hypothetical protein 0.0038 0.0126 0.0223
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.0454 1
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0078 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0131 0.0627
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0417 0.2081 0.2081
Schistosoma mansoni survival motor neuron protein 0.0051 0.0194 0.0194
Echinococcus multilocularis neuropeptide receptor A26 0.0396 0.1974 0.1974
Plasmodium vivax glutathione reductase, putative 0.004 0.0136 0.0651
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0191 1
Schistosoma mansoni tyrosine protein kinase 0.0417 0.2081 0.208
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis expressed conserved protein 0.0099 0.0438 0.0438
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Echinococcus multilocularis protein kinase 0.0417 0.2081 0.2081
Echinococcus multilocularis dna polymerase eta 0.0038 0.0122 0.0122
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0026 0.0566
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0 0.5
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Leishmania major DNA polymerase eta, putative 0.0038 0.0122 0.0585
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Schistosoma mansoni chromobox protein 0.0059 0.0234 0.0234
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0089 0.0426
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Brugia malayi TAR-binding protein 0.0113 0.0512 0.0995
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0021 0.0449
Loa Loa (eye worm) TK/ACK protein kinase 0.0417 0.2081 0.4042
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0594 0.2995 0.5818
Echinococcus multilocularis activin receptor type 0.0417 0.2082 0.2082
Plasmodium falciparum glutathione reductase 0.004 0.0136 0.0651
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0147 0.0285
Loa Loa (eye worm) RNA binding protein 0.0113 0.0512 0.0996
Loa Loa (eye worm) TK protein kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0092 0.044
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1011 0.5147 0.5147
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0092 0.044
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0417 0.2081 0.4042
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0059 0.3075
Leishmania major DNA polymerase eta, putative 0.0026 0.0064 0.0309
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0417 0.2081 0.4042
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0594 0.2995 0.5818
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0074 0.0144
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0417 0.2081 0.4042
Echinococcus multilocularis tar DNA binding protein 0.0113 0.0512 0.0512
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0113 0.0512 0.0996
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Plasmodium falciparum phd finger protein, putative 0.0031 0.0089 0.0426
Echinococcus granulosus tyrosine protein kinase Src64B 0.1011 0.5147 0.5147
Loa Loa (eye worm) TK/FER protein kinase 0.0417 0.2081 0.4042
Echinococcus multilocularis 0.0594 0.2995 0.2995
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0161 0.0161
Schistosoma mansoni tyrosine kinase 0.1011 0.5147 0.5147
Loa Loa (eye worm) TK/FER protein kinase 0.0417 0.2081 0.4042
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1011 0.5147 0.5147
Echinococcus multilocularis insulin receptor 0.0417 0.2081 0.2081
Loa Loa (eye worm) TK protein kinase 0.1011 0.5147 1
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Echinococcus multilocularis tensin 0.0594 0.2995 0.2995
Brugia malayi Protein kinase domain containing protein 0.1011 0.5147 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.0191 0.0191
Plasmodium falciparum tyrosine kinase-like protein 0.0417 0.2081 0.9994
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0417 0.2081 0.2081
Loa Loa (eye worm) SH2 domain-containing protein 0.0594 0.2995 0.5818
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.0454 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0161 0.0313
Echinococcus multilocularis tyrosine protein kinase shark 0.1011 0.5147 0.5147
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Plasmodium falciparum protein kinase, putative 0.0417 0.2082 1
Schistosoma mansoni hypothetical protein 0.0038 0.0126 0.0126
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1011 0.5147 0.5147
Treponema pallidum NADH oxidase 0.0014 0 0.5
Giardia lamblia Kinase, NEK 0.0417 0.2081 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0114
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0131 0.0602 0.0602
Trypanosoma brucei Flagellum attachment zone protein 20 0.0417 0.2081 0.9994
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Onchocerca volvulus 0.0594 0.2995 0.577
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1011 0.5147 0.5147
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis tyrosine protein kinase 0.0417 0.2081 0.2081
Brugia malayi RNA binding protein 0.0113 0.0512 0.0995
Brugia malayi intermediate filament protein 0.0029 0.0077 0.0149
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0059 0.3075
Entamoeba histolytica hypothetical protein 0.0038 0.0126 0.0223
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0594 0.2995 0.2995
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0594 0.2995 0.2995
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0136 0.0651
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1545 0.7903 0.7903
Schistosoma mansoni chromobox protein 0.0059 0.0234 0.0234
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0026 0.0123
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Brugia malayi MH2 domain containing protein 0.0127 0.0586 0.1138
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0092 0.044
Entamoeba histolytica hypothetical protein 0.0038 0.0126 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.005
Echinococcus multilocularis neuropeptide s receptor 0.0396 0.1974 0.1974
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0136 0.0651
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0015 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus granulosus tm gpcr rhodopsin 0.0636 0.3209 0.3209
Brugia malayi RNA recognition motif domain containing protein 0.0113 0.0512 0.0995
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0417 0.2082 1
Toxoplasma gondii protein kinase 0.0417 0.2081 0.9994
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0594 0.2995 0.2995
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Echinococcus multilocularis FL cytokine receptor 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0594 0.2995 0.577
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1011 0.5147 0.5147
Schistosoma mansoni growth factor receptor-bound protein 0.0594 0.2995 0.2995
Echinococcus granulosus SH2 motif 0.0594 0.2995 0.2995
Onchocerca volvulus 0.1011 0.5147 1
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0012 0.0023
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Giardia lamblia Protein 21.1 0.0417 0.2081 1
Echinococcus multilocularis SH2 motif 0.0594 0.2995 0.2995
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0337 0.1619
Schistosoma mansoni ephrin receptor 0.0417 0.2081 0.208
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0417 0.2081 0.9994
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0152 0.0152
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0417 0.2081 0.2081
Echinococcus multilocularis tyrosine protein kinase csk 0.0417 0.2081 0.2081
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.1231 0.1231
Echinococcus granulosus chromobox protein 1 0.0059 0.0234 0.0234
Brugia malayi cytokine inducible SH2-containing protein 5 0.0594 0.2995 0.5818
Loa Loa (eye worm) TK/FAK protein kinase 0.0417 0.2081 0.4042
Echinococcus granulosus neuropeptide receptor A26 0.0396 0.1974 0.1974
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0015
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0015 0.0015
Echinococcus multilocularis natriuretic peptide receptor 1 0.0417 0.2081 0.2081
Echinococcus multilocularis protein patched 0.0045 0.0161 0.0161
Echinococcus multilocularis protein kinase 0.0417 0.2081 0.2081
Loa Loa (eye worm) SH2 domain-containing protein 0.0594 0.2995 0.5818
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0417 0.2081 0.4042
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0417 0.2081 0.4029
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1011 0.5147 0.5147
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0079 0.0337 0.1618
Onchocerca volvulus 0.0417 0.2081 0.3973
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0417 0.2081 0.4042
Onchocerca volvulus Serine\/threonine kinase homolog 0.0079 0.0337 0.0547
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.2081 0.208
Schistosoma mansoni hypothetical protein 0.0417 0.2081 0.208
Echinococcus granulosus tumor protein p63 0.0361 0.1789 0.1789
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0015 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Brugia malayi SH2 domain containing protein 0.0594 0.2995 0.5818
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.2081 0.208
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0012 0.0056
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0417 0.2082 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0594 0.2995 0.2995
Brugia malayi hypothetical protein 0.0161 0.076 0.1477
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.0703 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Trypanosoma brucei protein kinase, putative 0.0417 0.2082 1
Loa Loa (eye worm) TK/FER protein kinase 0.1011 0.5147 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0073
Echinococcus granulosus tyrosine protein kinase pr2 0.0417 0.2081 0.2081
Schistosoma mansoni suppressor of cytokine signaling 0.0594 0.2995 0.2995
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0059 0.0092
Loa Loa (eye worm) RGC/RGC protein kinase 0.0417 0.2081 0.4042
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0337 0.0337
Giardia lamblia PHD finger protein 15 0.0031 0.0089 0.0426
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0417 0.2081 0.2081
Schistosoma mansoni hypothetical protein 0.0031 0.0089 0.0089
Echinococcus multilocularis protein KINase family member (kin 25) 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Toxoplasma gondii STE kinase 0.0417 0.2081 0.9994
Echinococcus multilocularis receptor type guanylyl cyclase 0.0417 0.2081 0.2081
Schistosoma mansoni DNA polymerase eta 0.0038 0.0122 0.0122
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1011 0.5147 0.5147
Entamoeba histolytica serine/threonine kinase, putative 0.0417 0.2081 0.4029
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0122 0.0585
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1011 0.5147 0.5147
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0092 0.044
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0417 0.2081 0.2081
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Onchocerca volvulus 0.0594 0.2995 0.577
Schistosoma mansoni tensin-related 0.0594 0.2995 0.2995
Trypanosoma cruzi DNA polymerase eta, putative 0.0026 0.0064 0.0309
Plasmodium falciparum tyrosine kinase-like protein 0.0417 0.2081 0.9994
Loa Loa (eye worm) hypothetical protein 0.0594 0.2995 0.5818
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0015 0.0073
Brugia malayi CHE-14 protein 0.0045 0.0161 0.0312
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Entamoeba histolytica hypothetical protein 0.0417 0.2081 0.4029
Schistosoma mansoni tyrosine kinase 0.1011 0.5147 0.5147
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0026 0.0124
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0594 0.2995 0.5818
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0417 0.2081 0.2081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0191 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0092 0.044
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0417 0.2081 0.4042
Echinococcus granulosus tyrosine kinase 0.0417 0.2081 0.2081
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0113 0.054
Echinococcus multilocularis lamin 0.0029 0.0077 0.0077
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0594 0.2995 0.2995
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0056
Echinococcus granulosus activated cdc42 kinase 1 0.0417 0.2081 0.2081
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0594 0.2996 0.5811
Echinococcus multilocularis tyrosine protein kinase csk 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0594 0.2995 0.2995
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0012 0.0257
Loa Loa (eye worm) TK/CSK protein kinase 0.0417 0.2081 0.4042
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0417 0.2081 0.4029
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0512 0.0512
Entamoeba histolytica protein kinase, putative 0.0417 0.2081 0.4029
Echinococcus granulosus chromobox protein 1 0.0059 0.0234 0.0234
Echinococcus granulosus expressed conserved protein 0.0594 0.2995 0.2995
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0417 0.2082 1
Brugia malayi Tensin 0.0594 0.2995 0.5818
Plasmodium vivax tyrosine kinase-like protein, putative 0.0417 0.2081 1
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.01 0.0478
Echinococcus granulosus tyrosine protein kinase Srms 0.1011 0.5147 0.5147
Echinococcus multilocularis chromobox protein 1 0.0059 0.0234 0.0234
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0059 0.0114
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0594 0.2995 0.2995
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0594 0.2995 0.2995
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Schistosoma mansoni protein kinase 0.0417 0.2082 0.2082
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.2081 0.4029
Onchocerca volvulus 0.0594 0.2995 0.577
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0417 0.2081 0.3973
Echinococcus granulosus fibroblast growth factor receptor 4 0.0417 0.2081 0.2081
Giardia lamblia Kinase, NEK 0.0417 0.2081 1
Echinococcus multilocularis epidermal growth factor receptor 0.0417 0.2081 0.2081
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0594 0.2995 0.2995
Echinococcus multilocularis c src tyrosine kinase 0.1011 0.5147 0.5147
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Echinococcus multilocularis heat shock protein 70 0.0417 0.2081 0.2081
Echinococcus multilocularis N chimaerin 0.0594 0.2995 0.2995
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.005
Loa Loa (eye worm) TK/EGFR protein kinase 0.0417 0.2081 0.4042
Brugia malayi hypothetical protein 0.1011 0.5147 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0417 0.2081 0.208
Entamoeba histolytica tyrosine kinase, putative 0.0417 0.2081 0.4029
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0 0.5
Brugia malayi isocitrate dehydrogenase 0.0017 0.0015 0.0029
Echinococcus multilocularis tyrosine kinase 0.0417 0.2081 0.2081
Echinococcus granulosus protein kinase 0.0417 0.2081 0.2081
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Loa Loa (eye worm) hypothetical protein 0.0417 0.2081 0.4042
Mycobacterium tuberculosis Probable reductase 0.0092 0.0401 0.8837
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Schistosoma mansoni protein kinase 0.0417 0.2081 0.208
Echinococcus granulosus integrin linked protein kinase 0.0417 0.2081 0.2081
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0092 0.044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0021 0.0449
Schistosoma mansoni ephrin receptor 0.0417 0.2081 0.208
Echinococcus granulosus tyrosine protein kinase shark 0.1011 0.5147 0.5147
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0122 0.0237
Brugia malayi Protein kinase domain containing protein 0.0417 0.2081 0.4042
Onchocerca volvulus 0.0417 0.2081 0.3973
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0337 0.1619
Schistosoma mansoni hypothetical protein 0.0029 0.0078 0.0078
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Trichomonas vaginalis TKL family protein kinase 0.0417 0.2081 1
Schistosoma mansoni tyrosine kinase 0.0417 0.2081 0.208

Activities

Activity type Activity value Assay description Source Reference
Ke (binding) = 0.17 nM Ability to displace U-69,593 from human recombinant Opioid receptor kappa 1 in CHO cells using [35S]- GTPgama S Assay ChEMBL. 12519069
Ke (binding) = 0.17 nM Ability to displace U-69,593 from human recombinant Opioid receptor kappa 1 in CHO cells using [35S]- GTPgama S Assay ChEMBL. 12519069
Ke (binding) = 3.31 nM Ability to displace DPDPE from human recombinant Opioid receptor delta 1 in CHO cells using [35S]- GTPgama S Assay ChEMBL. 12519069
Ke (binding) = 3.31 nM Ability to displace DPDPE from human recombinant Opioid receptor delta 1 in CHO cells using [35S]- GTPgama S Assay ChEMBL. 12519069
Ke (binding) = 5.33 nM Ability to displace DAMGO from human recombinant Opioid receptor mu 1 in CHO cells using [35S]- GTPgama S Assay ChEMBL. 12519069
Ke (binding) = 5.33 nM Ability to displace DAMGO from human recombinant Opioid receptor mu 1 in CHO cells using [35S]- GTPgama S Assay ChEMBL. 12519069
Ki (binding) = 0.3 nM Ability to displace [3H]-U69,593 from human recombinant Opioid receptor kappa 1 in CHO cells ChEMBL. 12519069
Ki (binding) = 0.3 nM Ability to displace [3H]-U69,593 from human recombinant Opioid receptor kappa 1 in CHO cells ChEMBL. 12519069
Ki (binding) = 38.22 nM Ability to displace [3H]-DPDPE from human recombinant Opioid receptor delta 1 in CHO cells ChEMBL. 12519069
Ki (binding) = 38.22 nM Ability to displace [3H]-DPDPE from human recombinant Opioid receptor delta 1 in CHO cells ChEMBL. 12519069
Ki (binding) = 219.16 nM Ability to displace [3H]-DAMGO from human recombinant Opioid receptor mu 1 in CHO cells ChEMBL. 12519069
Ki (binding) = 219.16 nM Ability to displace [3H]-DAMGO from human recombinant Opioid receptor mu 1 in CHO cells ChEMBL. 12519069
Ratio (binding) = 20 Selectivity between delta receptor and kappa receptor ChEMBL. 12519069
Ratio (binding) = 31 Selectivity between mu receptor and kappa receptor ChEMBL. 12519069
Ratio (binding) = 127 Selectivity between delta receptor and kappa receptor ChEMBL. 12519069
Ratio (binding) = 730 Selectivity between mu receptor and kappa receptor ChEMBL. 12519069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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