Detailed information for compound 1782713

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.505 | Formula: C21H32N4O
  • H donors: 1 H acceptors: 1 LogP: 3.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCN1C1CCN(C1)c1ccc(cc1)NC(=O)N1CCCCC1
  • InChi: 1S/C21H32N4O/c1-17-6-5-14-25(17)20-11-15-24(16-20)19-9-7-18(8-10-19)22-21(26)23-12-3-2-4-13-23/h7-10,17,20H,2-6,11-16H2,1H3,(H,22,26)
  • InChiKey: PYUCVLVRHYGSER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References
Macaca mulatta Histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Histamine receptor H3   445 aa 385 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0164 0.0445
Brugia malayi glutathione reductase 0.0047 0.0924 0.2506
Brugia malayi Sugar transporter family protein 0.0014 0.0164 0.0445
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0207 0.0859
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0018 0.0048
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Brugia malayi beta-lactamase family protein 0.0036 0.0663 0.1796
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0207 0.0569
Leishmania major trypanothione reductase 0.0047 0.0924 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0207 0.0044
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0164 0.0445
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0663 0.0997
Echinococcus multilocularis geminin 0.0165 0.3713 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0362 0.4832
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0545 0.1467
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Schistosoma mansoni hypothetical protein 0.0165 0.3713 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0663 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0562 0.0404
Echinococcus multilocularis solute carrier family 22 0.0014 0.0164 0.0442
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0362 0.0975
Brugia malayi hypothetical protein 0.0014 0.0164 0.0445
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0561 0.1521
Echinococcus granulosus GPCR family 2 0.0015 0.0189 0.0509
Onchocerca volvulus 0.0014 0.0164 0.0445
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0018 0.0049
Onchocerca volvulus 0.0014 0.0164 0.0445
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0362 0.5182
Leishmania major glucose transporter, lmgt2 0.0032 0.0571 0.5345
Loa Loa (eye worm) sugar transporter 0.0014 0.0164 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0164 0.0663
Trypanosoma brucei glucose transporter 2A 0.0032 0.0571 0.5345
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0189 0.0509
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.233 0.4331
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0483 0.13
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0663 0.0997
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0009 0.0034 0.0093
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.1979 0.5329
Schistosoma mansoni hypothetical protein 0.0102 0.2224 0.5989
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0189 0.0512
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0483 0.13
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0028 0.0483 0.13
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0924 0.152
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0483 0.13
Loa Loa (eye worm) hypothetical protein 0.0036 0.0663 0.1796
Loa Loa (eye worm) hypothetical protein 0.0008 0.0018 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0571 0.2505
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0971 0.263
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.5165 1
Brugia malayi Sugar transporter family protein 0.0102 0.2224 0.6028
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0546 0.1481
Onchocerca volvulus 0.0028 0.0483 0.1309
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0207 0.0067
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0924 0.2506
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0018 0.0048
Plasmodium vivax amine transporter, putative 0.0028 0.0483 0.0324
Onchocerca volvulus 0.0164 0.369 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0207 0.0044
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0571 0.5345
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0164 0.0663
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0234 0.0912
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0561 0.5221
Echinococcus multilocularis GPCR, family 2 0.0015 0.0189 0.0509
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0529 0.1424
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0665 0.6593
Schistosoma mansoni sugar transporter 0.0014 0.0164 0.0442
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.1309
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0207 0.0859
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.1309
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0028 0.0483 0.1309
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0164 0.0445
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0207 0.0044
Mycobacterium ulcerans beta-lactamase 0.0036 0.0663 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0571 0.2505
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0107 0.0289
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Echinococcus granulosus solute carrier family 22 0.0014 0.0164 0.0442
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0483 0.13
Loa Loa (eye worm) serotonin transporter b 0.0164 0.369 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0378 0.163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0546 0.1481
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2609 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0562 0.0404
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0164 0.0442
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0571 0.2505
Schistosoma mansoni transient receptor potential channel 0.0064 0.1338 0.3604
Loa Loa (eye worm) hypothetical protein 0.0031 0.0546 0.1481
Onchocerca volvulus 0.0014 0.0164 0.0445
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0665 0.6593
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0546 0.1471
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0571 0.2505
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2224 0.5989
Mycobacterium ulcerans hypothetical protein 0.0036 0.0663 1
Onchocerca volvulus 0.0014 0.0164 0.0445
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.0495
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Schistosoma mansoni hypothetical protein 0.0015 0.0189 0.0509
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0562 0.0617
Schistosoma mansoni sodium-dependent amino acid transporter 0.0028 0.0483 0.13
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0561 0.1511
Leishmania major glucose transporter, lmgt3 0.0032 0.0571 0.5345
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0546 0.1471
Mycobacterium tuberculosis Conserved protein 0.0036 0.0663 0.0997
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0362 0.156
Brugia malayi Thioredoxin reductase 0.0047 0.0924 0.2506
Onchocerca volvulus 0.0036 0.0663 0.1796
Onchocerca volvulus 0.0014 0.0164 0.0445
Echinococcus multilocularis General substrate transporter 0.0088 0.1887 0.5082
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0164 0.1428
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.1309
Echinococcus multilocularis solute carrier family 22 0.0014 0.0164 0.0442
Mycobacterium leprae Probable lipase LipE 0.0036 0.0663 0.1637
Echinococcus multilocularis serotonin transporter 0.0164 0.369 0.9936
Echinococcus multilocularis solute carrier family 22 0.0014 0.0164 0.0442
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0571 0.5345
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0362 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0663 0.1796
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0516 0.1389
Schistosoma mansoni sodium/chloride dependent transporter 0.0164 0.369 0.9936
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1338 0.3604
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0207 0.2171
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0561 0.1511
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0207 0.0569
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0207 0.0044
Schistosoma mansoni sugar transporter 0.0014 0.0164 0.0442
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0017 0.0221 0.0596
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1338 0.3604
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0282 0.0235
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2224 0.5989
Schistosoma mansoni hypothetical protein 0.0165 0.3713 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.369 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0483 0.13
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0546 0.1471
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0072 0.0195
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0546 0.1481
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0483 0.13
Loa Loa (eye worm) glutamate receptor 0.0014 0.0145 0.0394
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.233 0.4331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0189 0.0512
Loa Loa (eye worm) hypothetical protein 0.0028 0.0483 0.1309
Brugia malayi major facilitator superfamily protein 0.0014 0.0164 0.0445
Echinococcus granulosus serotonin transporter 0.0164 0.369 0.9936
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Onchocerca volvulus Putative transporter 0.0014 0.0164 0.0445
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0189 0.0509
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0164 0.0663
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0694 0.1881
Onchocerca volvulus 0.0014 0.0164 0.0445
Loa Loa (eye worm) hypothetical protein 0.0025 0.0413 0.1119
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0207 0.0086
Leishmania major protein kinase, putative 0.0031 0.0561 0.5221
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0546 0.2395
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0107 0.0289
Trypanosoma brucei trypanothione reductase 0.0047 0.0924 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0665 0.0779
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0663 0.2922
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0665 0.051
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0028 0.0483 0.13
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0571 0.2505
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Onchocerca volvulus 0.0028 0.0483 0.1309
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0663 0.0997
Leishmania major hypothetical protein, conserved 0.0036 0.0663 0.6557
Brugia malayi hypothetical protein 0.0014 0.0164 0.0445
Brugia malayi major facilitator superfamily protein 0.0014 0.0164 0.0445
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0207 0.0569
Loa Loa (eye worm) hypothetical protein 0.0025 0.0411 0.1115
Loa Loa (eye worm) norepinephrine transporter 0.0164 0.369 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0164 0.369 1
Plasmodium falciparum hexose transporter 0.0102 0.2224 0.2094
Loa Loa (eye worm) hypothetical protein 0.0023 0.0362 0.0982
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0663 0.1785
Schistosoma mansoni glucose transport protein 0.0102 0.2224 0.5989
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0545 0.1467
Brugia malayi Cam kinase protein 1 0.0031 0.0561 0.1521
Loa Loa (eye worm) hypothetical protein 0.0033 0.0609 0.165
Brugia malayi beta-lactamase family protein 0.0036 0.0663 0.1796
Brugia malayi hypothetical protein 0.0014 0.0164 0.0445
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Loa Loa (eye worm) hypothetical protein 0.0028 0.0483 0.1309
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0663 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0028 0.0483 0.13
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0018 0.0048
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0362 0.2604
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0561 0.1521
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0378 0.163
Schistosoma mansoni glucose transporter 0.0014 0.0164 0.0442
Schistosoma mansoni sugar transporter 0.0014 0.0164 0.0442
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0072 0.0194
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0562 0.0404
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0483 0.13
Onchocerca volvulus 0.0014 0.0164 0.0445
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0362 0.0346
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0483 0.13
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0561 0.1511
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.1979 0.5329
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0663 0.1785
Loa Loa (eye worm) hypothetical protein 0.0031 0.0561 0.1521
Onchocerca volvulus 0.0014 0.0164 0.0445
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0122 0.0332
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0483 0.13
Plasmodium falciparum thioredoxin reductase 0.0047 0.0924 0.0773
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.0495
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0018 0.0048
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0362 0.2604
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0663 0.2922
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0609 0.165
Schistosoma mansoni protein kinase 0.0031 0.0561 0.1511
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0663 0.1796
Echinococcus granulosus solute carrier family 22 0.0014 0.0164 0.0442
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0561 0.1521
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0164 0.0445
Onchocerca volvulus 0.0014 0.0164 0.0445
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0018 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Echinococcus granulosus voltage gated potassium channel 0.001 0.0072 0.0194
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0207 0.0559
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2224 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0663 0.1796
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0663 0.2922
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0164 0.0663
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0207 0.2171
Onchocerca volvulus 0.0014 0.0164 0.0445
Brugia malayi beta-lactamase 0.0036 0.0663 0.1796
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0663 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0164 0.0442
Onchocerca volvulus 0.0036 0.0663 0.1796
Onchocerca volvulus 0.0014 0.0164 0.0445
Mycobacterium tuberculosis Conserved protein 0.0036 0.0663 0.0997
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0663 0.6557
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0018 0.0048
Brugia malayi Receptor family ligand binding region containing protein 0.0009 0.0034 0.0093
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0207 0.0562
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0483 0.13
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0571 0.5345
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0072 0.0194
Schistosoma mansoni sugar transporter 0.0014 0.0164 0.0442
Loa Loa (eye worm) sugar transporter 0.0102 0.2224 0.6028
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0018 0.0048
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0562 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.1309
Plasmodium falciparum protein kinase 7 0.0288 0.6599 0.6542
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.233 0.4331
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0971 0.263
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0483 0.13
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2609 0.489
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0571 0.5345
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0018 0.0048
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0207 0.2171
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0561 0.1511
Trypanosoma cruzi hexose transporter 0.0032 0.0571 0.5345
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0164 0.0442
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0663 0.1785
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0164 0.0663
Loa Loa (eye worm) hypothetical protein 0.0164 0.369 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0665 0.6593
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0561 0.1511
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0546 0.1137
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0164 0.0442
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0694 0.1869
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0028 0.0491 0.1321
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0663 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0189 0.0512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.233 0.4331
Loa Loa (eye worm) beta-lactamase 0.0036 0.0663 0.1796
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0018 0.0048
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0362 0.6996
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0483 0.13
Loa Loa (eye worm) solute carrier family 6 member 4 0.0164 0.369 1
Trichomonas vaginalis esterase, putative 0.0036 0.0663 0.2922
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0207 0.0067
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Schistosoma mansoni protein kinase 0.0031 0.0561 0.1511
Treponema pallidum NADH oxidase 0.0016 0.0207 0.035
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2224 0.5989
Plasmodium falciparum glutathione reductase 0.0047 0.0924 0.0773
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Loa Loa (eye worm) hypothetical protein 0.0028 0.0483 0.1309
Schistosoma mansoni transient receptor potential channel 0.0096 0.2092 0.5634
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0164 0.1428
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0663 0.0997
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0924 0.2489
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0362 0.0975
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0296 0.1261
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0571 0.5345
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0207 0.0559
Entamoeba histolytica protein kinase, putative 0.0031 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0581 0.1574
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0207 0.0569
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0189 0.0512
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0164 0.1428
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0018 0.0048
Echinococcus granulosus geminin 0.0165 0.3713 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0562 0.0404
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0164 0.0442
Schistosoma mansoni hypothetical protein 0.0015 0.0189 0.0509
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0483 0.13
Schistosoma mansoni protein kinase 0.0031 0.0561 0.1511
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.37 0.3595
Onchocerca volvulus 0.0014 0.0164 0.0445
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0665 0.6593
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0014 0.0145 0.0391
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0164 0.0445
Onchocerca volvulus 0.0014 0.0164 0.0445
Schistosoma mansoni metabotropic glutamate receptor 0.0113 0.2473 0.666
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0562 0.0617
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0562 0.0404
Toxoplasma gondii hypothetical protein 0.0028 0.0483 0.0495
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0072 0.0194
Onchocerca volvulus 0.0014 0.0164 0.0445
Loa Loa (eye worm) hypothetical protein 0.0096 0.2092 0.567
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0164 0.0445
Loa Loa (eye worm) hypothetical protein 0.0037 0.0694 0.1881
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0663 0.0997
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0362 0.0975
Onchocerca volvulus 0.0014 0.0164 0.0445
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0561 0.1511
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0164 0.0663
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0018 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0663 0.6557
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0362 0.4832
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.2092 0.5634
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2224 0.5989
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0362 0.2604
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0189 0.0509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0561 0.1511
Mycobacterium tuberculosis Conserved protein 0.0036 0.0663 0.0997
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0207 0.1131
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0694 0.1869
Entamoeba histolytica protein kinase, putative 0.0031 0.0561 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2609 0.489
Plasmodium falciparum amino acid transporter, putative 0.0028 0.0483 0.0324
Brugia malayi hypothetical protein 0.0028 0.0483 0.1309
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Plasmodium vivax glutathione reductase, putative 0.0047 0.0924 0.0773
Loa Loa (eye worm) hypothetical protein 0.0036 0.0663 0.1796
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2609 0.489
Loa Loa (eye worm) glutamate receptor 0.0009 0.0034 0.0093
Mycobacterium ulcerans sugar transporter 0.0014 0.0164 0.1428
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0924 0.0773
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0663 0.6557
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0018 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0663 0.1796
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0072 0.0194
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0516 0.1389
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0561 0.1511
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1338 0.3604
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0562 0.0617
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0018 0.0048
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0924 0.2489
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0018 0.0048
Trypanosoma brucei glucose transporter 1E 0.0032 0.0571 0.5345
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0028 0.0491 0.1321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0971 0.263
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0207 0.0569
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0546 1
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.2092 0.5634
Echinococcus granulosus solute carrier family 22 0.0014 0.0164 0.0442
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2224 0.5989
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.37 0.5495
Toxoplasma gondii protein kinase, putative 0.0288 0.6599 1
Schistosoma mansoni glucose transport protein 0.0102 0.2224 0.5989
Loa Loa (eye worm) hypothetical protein 0.0028 0.0483 0.1309
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0028 0.0483 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0561 0.1511
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2224 0.3201
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0195
Loa Loa (eye worm) hypothetical protein 0.0036 0.0663 0.1796
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0663 0.0997
Schistosoma mansoni transient receptor potential channel 0.0064 0.1338 0.3604
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1225 0.3321
Loa Loa (eye worm) hypothetical protein 0.0164 0.369 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0207 0.0569
Toxoplasma gondii thioredoxin reductase 0.0047 0.0924 0.1181
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.233 0.4331
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0028 0.0483 0.13
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0663 0.1637
Schistosoma mansoni hypothetical protein 0.0015 0.0189 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0164 0.0663
Echinococcus granulosus General substrate transporter 0.0088 0.1887 0.5082
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.233 0.88
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0663 0.0997
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Loa Loa (eye worm) hypothetical protein 0.0017 0.0221 0.06
Brugia malayi Sugar transporter family protein 0.0014 0.0164 0.0445
Onchocerca volvulus 0.0036 0.0663 0.1796
Toxoplasma gondii ABC1 family protein 0.0036 0.0663 0.0775
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0072 0.0194
Plasmodium falciparum thioredoxin reductase 0.0016 0.0207 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0207 0.0569
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.37 0.3595
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2224 0.5989
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0018 0.0049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0483 0.1309
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0028 0.0491 0.133
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Onchocerca volvulus 0.0028 0.0483 0.1309
Leishmania major glucose transporter, lmgt1 0.0032 0.0571 0.5345
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0282 0.0235
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0362 0.0308
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0207 0.3143
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2224 0.5989
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0665 0.6593
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0207 0.0569
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0189 0.0509
Treponema pallidum sodium- and chloride- dependent transporter 0.0164 0.369 1
Schistosoma mansoni glucose transport protein 0.0102 0.2224 0.5989
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Loa Loa (eye worm) glutathione reductase 0.0047 0.0924 0.2506
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0562 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0571 0.5345
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0207 0.0559
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0028 0.0491 0.133
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0571 0.5345
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0483 0.13
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0018 0.0048
Plasmodium vivax hexose transporter 0.0102 0.2224 0.2094
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.0495
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.2092 0.5634
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0571 0.2505
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0483 0.0324
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Brugia malayi Metabotropic glutamate receptor precursor. 0.0009 0.0034 0.0093
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0483 0.13
Mycobacterium tuberculosis Probable reductase 0.0107 0.233 0.4331
Loa Loa (eye worm) hypothetical protein 0.0036 0.0663 0.1796
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0018 0.0048
Brugia malayi metabotropic glutamate receptor type 2 0.0017 0.0221 0.06
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.0445
Plasmodium falciparum glutathione reductase 0.0016 0.0207 0.0044
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0665 0.051
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0663 0.1785
Loa Loa (eye worm) hypothetical protein 0.0049 0.0971 0.263
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2224 0.5989
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0561 0.2462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0207 0.0569
Loa Loa (eye worm) hypothetical protein 0.0028 0.0483 0.1309
Plasmodium falciparum transporter, putative 0.0028 0.0483 0.0324
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0164 0.369 0.9936
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0924 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0362 0.0982
Echinococcus multilocularis solute carrier family 22 0.0014 0.0164 0.0442
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0093
Echinococcus granulosus solute carrier family 22 0.0014 0.0164 0.0442
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0546 0.9253
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0546 0.1471
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0018 0.0048
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0562 0.0404
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0028 0.0483 0.13
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0663 0.2922
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0207 0.0569
Schistosoma mansoni hypothetical protein 0.0033 0.0609 0.1639
Loa Loa (eye worm) hypothetical protein 0.0028 0.0483 0.1309
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1338 0.3604
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0571 0.2505
Toxoplasma gondii hypothetical protein 0.0028 0.0483 0.0495
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0362 0.0201
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0164 0.0663
Echinococcus granulosus metabotropic glutamate receptor 5 0.0017 0.0221 0.0596
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0562 0.0404
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0483 0.1309
Schistosoma mansoni hypothetical protein 0.0015 0.0189 0.0509
Trypanosoma brucei glucose transporter, putative 0.0032 0.0571 0.5345
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0018 0.0048
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0362 0.0975
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0663 0.2922
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0164 0.0663
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0009 0.0034 0.0093

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.3 nM Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed as inhibition of calcium mobilization by FLIPR assay ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human MCH1R assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human histamine H1 receptor assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) < 40 % Antagonist activity at human histamine H2 receptor assessed as inhibition of calcium mobilization at 10 uM by FLIPR assay relative to control ChEMBL. 23591110
Inhibition (functional) = 108 % Antagonist activity at human histamine H3 receptor in human T-REx-293 cells assessed as inhibition of basal GTPgammaS binding at 10 uM after 90 mins by scintillation counting analysis relative to control ChEMBL. 23591110
Ki (binding) = 6 nM Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation counting analysis ChEMBL. 23591110

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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