Detailed information for compound 178864

Basic information

Technical information
  • TDR Targets ID: 178864
  • Name: 2-bromo-3-[[4-(2-chlorophenyl)piperazin-1-yl] methyl]-[1,3]thiazolo[2,3-b]quinazolin-5-one
  • MW: 489.816 | Formula: C21H18BrClN4OS
  • H donors: 0 H acceptors: 1 LogP: 4.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1N1CCN(CC1)Cc1c(Br)sc2n1c(=O)c1c(n2)cccc1
  • InChi: 1S/C21H18BrClN4OS/c22-19-18(27-20(28)14-5-1-3-7-16(14)24-21(27)29-19)13-25-9-11-26(12-10-25)17-8-4-2-6-15(17)23/h1-8H,9-13H2
  • InChiKey: IBBJIYNHPADRCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-3-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]thiazolo[2,3-b]quinazolin-5-one
  • 2-bromo-3-[[4-(2-chlorophenyl)-1-piperazinyl]methyl]-5-thiazolo[2,3-b]quinazolinone
  • 2-bromo-3-[[4-(2-chlorophenyl)piperazino]methyl]thiazolo[2,3-b]quinazolin-5-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutathione reductase 0.0062 0.0471 0.1174
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1503 1
Echinococcus multilocularis protein cereblon 0.0296 0.2508 0.6213
Brugia malayi RE15519p 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0181 0.1503 0.3748
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0051 0.0127
Brugia malayi beta-lactamase family protein 0.0181 0.1503 0.3748
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2009 0.501
Schistosoma mansoni hypothetical protein 0.0296 0.2508 0.7319
Brugia malayi beta-lactamase family protein 0.0181 0.1503 0.3748
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0167 0.0376
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0065 0.0189
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0065 0.0189
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0315 0.1203
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0086 0.0327
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0065 0.0189
Onchocerca volvulus Dual oxidase homolog 0.0239 0.2009 0.8012
Onchocerca volvulus 0.0016 0.0065 0.0256
Echinococcus multilocularis peroxidasin 0.0239 0.2009 0.4978
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.011 0.0734
Brugia malayi hypothetical protein 0.0032 0.0204 0.0509
Brugia malayi putative neuropeptide receptor 0.0016 0.0065 0.0162
Schistosoma mansoni cpg binding protein 0.0057 0.0427 0.1245
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0002 0.0006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0242 0.0925
Schistosoma mansoni inositol monophosphatase 0.0036 0.0242 0.0708
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0051 0.0126
Schistosoma mansoni cpg binding protein 0.0061 0.0455 0.1329
Schistosoma mansoni peroxidasin 0.0239 0.2009 0.5864
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0086 0.0571
Loa Loa (eye worm) inositol-1 0.0036 0.0242 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0159 0.0606
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0191 0.0476
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0066 0.0193
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0242 0.161
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus granulosus orexin receptor type 2 0.0016 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Brugia malayi nuclear receptor NHR-88 0.003 0.0191 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0159 0.0606
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0252
Brugia malayi CXXC zinc finger family protein 0.0057 0.0427 0.1064
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0115 0.0762
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0191 0.0759
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0115 0.0437
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0625 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0111 0.0274
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0191 0.0473
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0625 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0065 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1124 0.3279
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0449 0.0448
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0115 0.0439
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.0765
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0356 0.2371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0157 0.0597
Plasmodium vivax hypothetical protein, conserved 0.0181 0.1503 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0356 0.0889
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0988 0.2882
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0625 0.3954
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0065 0.016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1124 0.2802
Onchocerca volvulus 0.0016 0.0065 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1124 0.2784
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0081 0.0201
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0305 0.2592 0.7564
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.061
Onchocerca volvulus 0.0016 0.0065 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0065 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0236 0.0899
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0449 0.2982
Brugia malayi hypothetical protein 0.0073 0.0561 0.1399
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0115 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0191 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0181 0.1503 0.3748
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0115 0.0533
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0002 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0065 0.016
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0065 0.016
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0002 0.0006
Onchocerca volvulus 0.0016 0.0065 0.0256
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0065 0.016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0191 0.0473
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0216 0.0823
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0191 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0191 0.0476
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0065 0.016
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0191 0.0476
Brugia malayi nuclear receptor NHR-88 0.0014 0.0051 0.0128
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.005 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0065 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0242 0.0925
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0141 0.116 0.2874
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0065 0.016
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0115 0.1808
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1016 0.2966
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0165
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0191 0.0476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Schistosoma mansoni hypothetical protein 0.0022 0.0119 0.0348
Schistosoma mansoni nuclear receptor 0.0014 0.0051 0.0149
Mycobacterium tuberculosis Probable esterase LipL 0.0181 0.1503 0.1503
Echinococcus granulosus serotonin receptor 0.0016 0.0065 0.016
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0065 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.052
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0002 0.0006
Brugia malayi Probable ClpP-like protease 0.008 0.0625 0.1559
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.1503 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0115 0.0765
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0191 0.0557
Loa Loa (eye worm) glutathione reductase 0.0062 0.0471 0.1174
Brugia malayi Inositol-1 0.0036 0.0242 0.0605
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0066 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0187 0.0714
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0051 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0065 0.016
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0065 0.016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0447 0.3825 0.9538
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0191 0.0473
Brugia malayi beta-lactamase 0.0181 0.1503 0.3748
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0191 0.0473
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.0765
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0051 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.052
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0065 0.0162
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0025 0.0165
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0065 0.016
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0051 0.0128
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0315 0.1965
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0141 0.116 0.2874
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0002 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0065 0.0162
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.1243 0.8126
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Loa Loa (eye worm) RecQ helicase 0.0021 0.0111 0.0276
Entamoeba histolytica hypothetical protein 0.0073 0.0561 0.214
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0181 0.1503 1
Brugia malayi hypothetical protein 0.0016 0.0066 0.0165
Entamoeba histolytica hypothetical protein 0.0073 0.0561 0.214
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0065 0.0162
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0065 0.0162
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0066 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Onchocerca volvulus 0.0016 0.0065 0.0256
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0005
Onchocerca volvulus 0.0057 0.0427 0.17
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0065 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0236 0.0899
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Brugia malayi hypothetical protein 0.0014 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Entamoeba histolytica hypothetical protein, conserved 0.0296 0.2508 0.9565
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0236 0.157
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0191 0.0476
Schistosoma mansoni biogenic amine receptor 0.0016 0.0065 0.0189
Leishmania major hypothetical protein, conserved 0.0049 0.0356 0.2243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0191 0.0473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1124 0.2784
Schistosoma mansoni myosin xvIII 0.0016 0.0065 0.0189
Brugia malayi MH2 domain containing protein 0.0116 0.0938 0.2339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1124 0.2784
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0057 0.0216
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0413 0.1031
Trichomonas vaginalis helicase, putative 0.0013 0.004 0.0152
Onchocerca volvulus Peroxidase homolog 0.0239 0.2009 0.8012
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0065 0.0189
Schistosoma mansoni amine GPCR 0.0016 0.0065 0.0189
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0115 0.0441
Brugia malayi hypothetical protein 0.0016 0.0066 0.0165
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.1243 0.8269
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Toxoplasma gondii hypothetical protein 0.0009 0.0002 0.0013
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0115 0.0765
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2009 0.501
Onchocerca volvulus 0.0016 0.0065 0.0256
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0065 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Giardia lamblia GTOR 0.0045 0.0315 0.1201
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0449 0.2866
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0167 0.2645
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0025 0.0095
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0115 0.0533
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0315 0.0786
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0051 0.0202
Brugia malayi Latrophilin receptor protein 2 0.0141 0.116 0.2893
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0141 0.116 0.3386
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0115 0.0336
Schistosoma mansoni hypothetical protein 0.0256 0.2156 0.6294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0216 0.0823
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0115 0.1808
Schistosoma mansoni zinc finger protein 0.0014 0.0051 0.0149
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0051 0.0127
Loa Loa (eye worm) latrophilin receptor protein 2 0.0141 0.116 0.2893
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0065 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0356 0.2371
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0006
Echinococcus granulosus allatostatin A receptor 0.0016 0.0065 0.016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0315 0.2098
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0496 0.3302
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0065 0.016
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2009 0.501
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0561 0.1638
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0625 0.4159
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0065 0.016
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0025 0.0165
Schistosoma mansoni hypothetical protein 0.0016 0.0065 0.0189
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0065 0.0162
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0242 0.0601
Brugia malayi Melatonin receptor type 1A 0.0016 0.0065 0.0162
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0051 0.0149
Brugia malayi Peroxidasin 0.0239 0.2009 0.501
Brugia malayi nuclear receptor RXR 0.0016 0.0066 0.0165
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0065 0.0256
Brugia malayi neuropeptide F receptor 0.0016 0.0065 0.0162
Brugia malayi larval opioid receptor 0.0016 0.0065 0.0162
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0242 0.0925
Loa Loa (eye worm) RNA binding protein 0.0125 0.1016 0.2534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0191 0.0476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0191 0.0473
Echinococcus granulosus sex peptide receptor 0.0016 0.0065 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0447 0.3825 0.9538
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0057 0.0378
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0115 0.061
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0065 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Mycobacterium tuberculosis Conserved protein 0.0181 0.1503 0.1503
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.0471 0.047
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0065 0.016
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.1243 0.1243
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0183
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0051 0.0127
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0236 0.157
Mycobacterium tuberculosis Conserved protein 0.0181 0.1503 0.1503
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0065 0.0189
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0065 0.016
Mycobacterium tuberculosis Probable hydrolase 0.0181 0.1503 0.1503
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0625 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Onchocerca volvulus 0.0016 0.0065 0.0256
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2009 0.501
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0057 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0191 0.0476
Brugia malayi conserved hypotetical protein 0.0014 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1016 0.2966
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0065 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0065 0.016
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0072 0.021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0065 0.016
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0065 0.016
Onchocerca volvulus 0.0181 0.1503 0.5994
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0066 0.0165
Plasmodium falciparum thioredoxin reductase 0.0022 0.0115 0.1808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0057 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0216 0.0823
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0191 0.0473
Plasmodium falciparum thioredoxin reductase 0.0062 0.0471 0.7519
Mycobacterium tuberculosis Probable lipase LipE 0.0181 0.1503 0.1503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0065 0.0162
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0181 0.1503 0.1503
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0115 0.0765
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0088 0.0585
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0165
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0081 0.0201
Brugia malayi latrophilin 2 splice variant baaae 0.0305 0.2592 0.6462
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.4036 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0561 0.139
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0315 0.1203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Schistosoma mansoni neuropeptide receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0315 0.2098
Onchocerca volvulus Protein cereblon homolog 0.0296 0.2508 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0315 0.092
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0236 0.1429
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0471 0.1166
Loa Loa (eye worm) blistered cuticle protein 3 0.0239 0.2009 0.501
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0115 0.0285
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Echinococcus granulosus dnaJ subfamily B 0.0401 0.3426 0.8488
Schistosoma mansoni amine GPCR 0.0016 0.0065 0.0189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0141 0.116 0.2874
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Schistosoma mansoni biogenic amine receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0111 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.0519
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0111 0.0422
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0051 0.0127
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0088 0.1378
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0191 0.0557
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.1347
Echinococcus granulosus fmrfamide receptor 0.0016 0.0065 0.016
Schistosoma mansoni hypothetical protein 0.0073 0.0561 0.1638
Mycobacterium ulcerans beta-lactamase 0.0181 0.1503 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0065 0.0162
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0496 0.3189
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0002 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0157 0.0597
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0065 0.016
Schistosoma mansoni DNA helicase recq5 0.0009 0.0002 0.0007
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0167 0.08
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1503 0.5734
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0625 0.4159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Leishmania major hypothetical protein, conserved 0.0181 0.1503 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0496 0.1449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1124 0.3279
Brugia malayi G-protein coupled receptor 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2009 0.501
Entamoeba histolytica hypothetical protein 0.0073 0.0561 0.214
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0065 0.0189
Loa Loa (eye worm) hypothetical protein 0.0176 0.146 0.3641
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0065 0.016
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0252
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0384 0.0952
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0449 0.1111
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0356 0.2371
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0181 0.1503 0.3748
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0181 0.1503 0.1503
Schistosoma mansoni hypothetical protein 0.0016 0.0065 0.0189
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0181 0.1503 0.3748
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0256 0.0635
Onchocerca volvulus 0.0009 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0051 0.0128
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0625 0.1549
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0065 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0216 0.0823
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0065 0.016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0086 0.0214
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0191 0.0476
Brugia malayi Dopamine receptor 0.0016 0.0065 0.0162
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0065 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Brugia malayi DIX domain containing protein 0.0009 0.0002 0.0005
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.146 0.5822
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.1613
Echinococcus granulosus neuropeptide receptor 0.0016 0.0065 0.016
Brugia malayi nuclear hormone receptor 0.0014 0.0051 0.0128
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0315 0.0781
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0115 0.0762
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0191 0.0473
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0065 0.016
Mycobacterium ulcerans hypothetical protein 0.0181 0.1503 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0051 0.0127
Schistosoma mansoni thyroid hormone receptor 0.0286 0.2421 0.7066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Schistosoma mansoni cpg binding protein 0.0061 0.0455 0.1329
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0081 0.0203
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0086 0.0416
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0005
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0002 0.0005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0086 0.0329
Schistosoma mansoni DNA helicase recq1 0.0009 0.0002 0.0007
Schistosoma mansoni hypothetical protein 0.0016 0.0065 0.0189
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0065 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0065 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.052
Echinococcus multilocularis serotonin receptor 0.0016 0.0065 0.016
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0008 0.0001 0.0002
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1016 0.2966
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0065 0.016
Schistosoma mansoni nuclear receptor 0.0014 0.0051 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.0765
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0625 0.1825
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0051 0.0149
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0086 0.0214
Treponema pallidum fructose-bisphosphate aldolase 0.0309 0.2622 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1016 0.2966
Loa Loa (eye worm) hypothetical protein 0.0181 0.1503 0.3748
Onchocerca volvulus 0.0016 0.0065 0.0256
Schistosoma mansoni coup transcription factor 0.003 0.0191 0.0557
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0065 0.016
Echinococcus multilocularis cpg binding protein 0.0061 0.0455 0.1128
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0449 0.1309
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0496 0.1893
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0065 0.016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0449 0.2982
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2009 0.501
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0575
Schistosoma mansoni hypothetical protein 0.0141 0.116 0.3386
Onchocerca volvulus 0.0016 0.0065 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0179 0.0682
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0065 0.016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0191 0.0476
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0057 0.0141
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0065 0.016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0051 0.0126
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Entamoeba histolytica hypothetical protein 0.0073 0.0561 0.214
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0115 0.0115
Onchocerca volvulus 0.0181 0.1503 0.5994
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1016 0.2966
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0191 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0191 0.0476
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0065 0.0162
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0115 0.0285
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Schistosoma mansoni amine GPCR 0.0016 0.0065 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0191 0.0476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0625 0.4157
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0938 0.2339
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.1472
Schistosoma mansoni peroxidasin 0.0239 0.2009 0.5864
Schistosoma mansoni dep domain containing protein 0.0009 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.2622 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.3426 0.8488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0191 0.0476
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0315 0.0786
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0057 0.0378
Onchocerca volvulus 0.0239 0.2009 0.8012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0051 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0191 0.0473
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0242 0.0601
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1503 0.5734
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0384 0.1941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0057 0.0217
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0115 0.0439
Brugia malayi RNA binding protein 0.0125 0.1016 0.2534
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0065 0.016
Onchocerca volvulus Peroxidasin homolog 0.0239 0.2009 0.8012
Schistosoma mansoni hypothetical protein 0.0141 0.116 0.3386
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0065 0.0189
Echinococcus multilocularis sex peptide receptor 0.0016 0.0065 0.016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0286 0.2421 0.5998
Onchocerca volvulus 0.0239 0.2009 0.8012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0625 1
Schistosoma mansoni nuclear hormone receptor 0.003 0.0191 0.0557
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0209 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1503 0.5734
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Brugia malayi Thioredoxin reductase 0.0062 0.0471 0.1174
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0065 0.0189
Toxoplasma gondii thioredoxin reductase 0.0062 0.0471 0.3131
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.1613
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0874 0.5815
Brugia malayi neuropeptide F receptor 0.0016 0.0065 0.0162
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0625 0.2125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1124 0.2784
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0065 0.016
Onchocerca volvulus Chorion peroxidase homolog 0.0239 0.2009 0.8012
Echinococcus multilocularis tar DNA binding protein 0.0125 0.1016 0.2517
Onchocerca volvulus 0.0016 0.0065 0.0256
Echinococcus granulosus beta LACTamase domain containing family member 0.0181 0.1503 0.3724
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0065 0.0162
Schistosoma mansoni hypothetical protein 0.0016 0.0065 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0356 0.5684
Brugia malayi sulfakinin receptor protein 0.0016 0.0065 0.0162
Onchocerca volvulus 0.0014 0.0051 0.0202
Loa Loa (eye worm) hypothetical protein 0.0181 0.1503 0.3748
Schistosoma mansoni opsin-like receptor 0.0016 0.0065 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0236 0.0899
Onchocerca volvulus 0.0016 0.0065 0.0256
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0065 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0216 0.0823
Mycobacterium tuberculosis Probable lipase LipD 0.0181 0.1503 0.1503
Schistosoma mansoni adenoreceptor 0.0016 0.0065 0.0189
Brugia malayi hypothetical protein 0.0049 0.0356 0.0889
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0002 0.0006
Echinococcus granulosus peroxidasin 0.0239 0.2009 0.4978
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0115 0.0765
Brugia malayi follicle stimulating hormone receptor 0.0468 0.4011 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0065 0.016
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0329
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0051 0.0128
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0167 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Trypanosoma brucei trypanothione reductase 0.0062 0.0471 0.3131
Schistosoma mansoni amine GPCR 0.0016 0.0065 0.0189
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0115 0.0765
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0191 0.0557
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Brugia malayi tailless protein 0.0014 0.0051 0.0128
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0066 0.0164
Schistosoma mansoni hypothetical protein 0.0401 0.3426 1
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0002 0.0005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0065 0.0189
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0141 0.116 0.2874
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0065 0.016
Schistosoma mansoni biogenic amine receptor 0.0016 0.0065 0.0189
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0065 0.016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Brugia malayi Blistered cuticle protein 3 0.0239 0.2009 0.501
Echinococcus granulosus GPCR family 2 0.0141 0.116 0.2874
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0115 0.0762
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.1016 0.2534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.0519
Echinococcus granulosus g protein coupled receptor 0.0016 0.0065 0.016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0191 0.0473
Brugia malayi nuclear receptor RXR 0.0014 0.0051 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0191 0.0476
Brugia malayi Dopamine receptor protein 1 0.0016 0.0065 0.0162
Brugia malayi TAR-binding protein 0.0125 0.1016 0.2534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1124 0.3279
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0065 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0216 0.0823
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0086 0.0086
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.0471 0.289
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.4036 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0115 0.0441
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0468 0.4011 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0066 0.0165
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0051 0.0126
Mycobacterium tuberculosis Conserved protein 0.0181 0.1503 0.1503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Schistosoma mansoni neuropeptide receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.0765
Onchocerca volvulus 0.0016 0.0065 0.0256
Trichomonas vaginalis esterase, putative 0.0181 0.1503 0.5734
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0191 0.0473
Loa Loa (eye worm) hypothetical protein 0.003 0.0191 0.0476
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0065 0.016
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0119 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0065 0.016
Brugia malayi AKH receptor 0.0016 0.0065 0.0162
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0065 0.016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0115 0.0765
Echinococcus granulosus protein cereblon 0.0296 0.2508 0.6213
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.1016 0.2534
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.2622 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0065 0.016
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0065 0.0162
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0315 0.0781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0181 0.1503 0.3724
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0115 0.0765
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2009 0.501
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0242 0.0925
Mycobacterium ulcerans esterase/lipase LipP 0.0181 0.1503 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0065 0.016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0191 0.0557
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0191 0.0557
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0057 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0065 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0236 0.0899
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0191 0.0476
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0191 0.0476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0165
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0005
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0065 0.0189
Echinococcus multilocularis geminin 0.0337 0.2865 0.7097
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0017
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0065 0.016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0496 0.3302
Brugia malayi Serotonin receptor 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0051 0.0127
Echinococcus granulosus hypothetical protein 0.0016 0.0065 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0159 0.0606
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0141 0.116 0.2893
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Echinococcus granulosus somatostatin receptor 0.0016 0.0065 0.016
Brugia malayi GnHR receptor homolog 0.0016 0.0065 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.004 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0315 0.1203
Onchocerca volvulus 0.0016 0.0065 0.0256
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0256 0.0635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Brugia malayi ecdysone receptor 0.0014 0.0051 0.0128
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0065 0.0162
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0115 0.0765
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0086 0.0215
Echinococcus granulosus g protein coupled receptor 0.0016 0.0065 0.016
Onchocerca volvulus 0.0016 0.0065 0.0256
Schistosoma mansoni opsin-like receptor 0.0016 0.0065 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0191 0.0476
Onchocerca volvulus 0.0016 0.0065 0.0256
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0057 0.0378
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0057 0.0216
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2009 0.501
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Brugia malayi hypothetical protein 0.0016 0.0065 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0356 0.2371
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0496 0.1238
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1124 0.2802
Brugia malayi steroid hormone receptor 0.003 0.0191 0.0476
Onchocerca volvulus 0.0181 0.1503 0.5994
Echinococcus granulosus bloom syndrome protein 0.0021 0.0111 0.0274
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0115 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0051 0.0127
Leishmania major trypanothione reductase 0.0062 0.0471 0.3016
Schistosoma mansoni neuropeptide receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) hypothetical protein 0.0141 0.116 0.2893
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0065 0.0162
Brugia malayi nuclear receptor NHR-67 0.0014 0.0051 0.0128
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0625 0.3675
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0086 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0191 0.0476
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0086 0.0575
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0119 0.0296
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Echinococcus granulosus neuropeptide s receptor 0.0471 0.4036 1
Brugia malayi nuclear hormone receptor 0.003 0.0191 0.0476
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0384 0.0952
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0005
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0315 0.2098
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0065 0.0162
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0242 0.1613
Schistosoma mansoni histamine h1 receptor 0.0016 0.0065 0.0189
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0115 0.0287
Echinococcus granulosus geminin 0.0337 0.2865 0.7097
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0471 0.3131
Onchocerca volvulus 0.003 0.0191 0.0759
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0938 0.2339
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.0471 0.1174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0057 0.0217
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0051 0.0127
Echinococcus granulosus g protein coupled receptor 0.0016 0.0065 0.016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0065 0.016
Plasmodium falciparum glutathione reductase 0.0022 0.0115 0.1808
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Brugia malayi Serotonin receptor 0.0016 0.0065 0.0162
Treponema pallidum NADH oxidase 0.0022 0.0115 0.0113
Schistosoma mansoni hypothetical protein 0.0337 0.2865 0.8361
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0066 0.0193
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0256 0.2156 0.5343
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0384 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0181 0.1503 0.3748
Loa Loa (eye worm) hypothetical protein 0.0314 0.2665 0.6645
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0051 0.0128
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0079 0.0198
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0356 0.5684
Brugia malayi G-protein coupled receptor 0.0016 0.0065 0.0162
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0209 0.0679
Brugia malayi Dopamine receptor protein 2 0.0016 0.0065 0.0162
Schistosoma mansoni inositol monophosphatase 0.0036 0.0242 0.0708
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0191 0.0557
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0191 0.0473
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1503 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0002 0.0005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0051 0.0128
Mycobacterium ulcerans lipase LipD 0.0181 0.1503 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0065 0.0162
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0561 0.139
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0051 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0258 0.0986
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0152
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Plasmodium vivax glutathione reductase, putative 0.0062 0.0471 0.289
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0065 0.016
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0065 0.016
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0065 0.016
Brugia malayi G protein-coupled receptor 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0002 0.0006
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0065 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Brugia malayi Sulfatase family protein 0.0008 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.0016 0.0065 0.0189
Echinococcus granulosus FTZ F1 alpha 0.003 0.0191 0.0473
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0191 0.0473
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0065 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0065 0.016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0191 0.0476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0065 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0315 0.1203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0315 0.1203
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0191 0.0476
Brugia malayi hypothetical protein 0.0009 0.0002 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0191 0.0557
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0128
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0065 0.016
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0002 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.0243
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0496 0.3302
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0065 0.016
Toxoplasma gondii exonuclease III APE 0.0018 0.0086 0.0575
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0191 0.0759
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0065 0.016
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0006
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0256 0.2156 0.5343
Loa Loa (eye worm) hypothetical protein 0.0305 0.2592 0.6462
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0115 0.061
Mycobacterium leprae conserved hypothetical protein 0.0181 0.1503 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0181 0.1503 0.3748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0051 0.0127
Toxoplasma gondii ABC1 family protein 0.0181 0.1503 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1503 0.5734
Brugia malayi hypothetical protein 0.0009 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0051 0.0149
Brugia malayi ORL1-like opioid receptor 0.0016 0.0065 0.0162
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0051 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0191 0.0476
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2009 0.501
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0002 0.0006
Echinococcus granulosus neuropeptide receptor 0.0016 0.0065 0.016
Brugia malayi ecdysteroid receptor 0.003 0.0191 0.0476
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0065 0.0189
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0191 0.0557
Echinococcus multilocularis somatostatin receptor 0.0016 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0191 0.0759
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.008 0.0625 0.1559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.0519
Schistosoma mansoni amine GPCR 0.0016 0.0065 0.0189
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0057 0.0378
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0329
Onchocerca volvulus Peroxidasin homolog 0.0239 0.2009 0.8012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0065 0.016
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.4036 1
Onchocerca volvulus 0.0016 0.0065 0.0256
Toxoplasma gondii hypothetical protein 0.0028 0.0167 0.1112
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0216 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0051 0.0126
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0191 0.0557
Plasmodium falciparum glutathione reductase 0.0062 0.0471 0.7519
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0065 0.016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0191 0.0476
Schistosoma mansoni hypothetical protein 0.0141 0.116 0.3386
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2622 1
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0065 0.016
Mycobacterium leprae Probable lipase LipE 0.0181 0.1503 1
Brugia malayi hypothetical protein 0.0014 0.0051 0.0128
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0002 0.0007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0315 0.2098
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0384 0.0384
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0625 0.4157
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0449 0.1111
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0008 0.0001 0.0002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0315 0.1965
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0065 0.0162
Echinococcus multilocularis serotonin receptor 0.0016 0.0065 0.016
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0496 0.123
Loa Loa (eye worm) beta-lactamase 0.0181 0.1503 0.3748
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) DR-78 0.0014 0.0051 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0008 0.0032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0115 0.0765
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0065 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0216 0.0823
Onchocerca volvulus 0.0014 0.0051 0.0202
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0065 0.016
Giardia lamblia Fructose-bisphosphate aldolase 0.0309 0.2622 1
Schistosoma mansoni neuropeptide receptor 0.0016 0.0065 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0065 0.0189
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0356 0.2103
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0051 0.0127
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0471 0.1166
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0057 0.0141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0447 0.3825 0.9538
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Brugia malayi hypothetical protein 0.012 0.0977 0.2437
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1503 0.4387
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0111 0.0276
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0008 0.0056
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0191 0.0473
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0449 0.1119
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0025 0.0095
Loa Loa (eye worm) TAR-binding protein 0.0125 0.1016 0.2534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0057 0.0217
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0427 0.1064
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0496 0.1238
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0239 0.2009 0.501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0057 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0236 0.0899
Echinococcus multilocularis GPCR, family 2 0.0141 0.116 0.2874
Brugia malayi hypothetical protein 0.0239 0.2009 0.501
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0051 0.0149
Schistosoma mansoni thyroid hormone receptor 0.0286 0.2421 0.7066
Echinococcus granulosus tar DNA binding protein 0.0125 0.1016 0.2517
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0065 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0117
Onchocerca volvulus 0.0239 0.2009 0.8012
Schistosoma mansoni hypothetical protein 0.0337 0.2865 0.8361
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0447 0.3825 0.9538
Onchocerca volvulus Peroxidase homolog 0.0239 0.2009 0.8012
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0065 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1503 0.4387
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0115 0.0115
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0191 0.0473
Brugia malayi N-terminal motif family protein 0.0176 0.146 0.3641
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0191 0.0476
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0181 0.1503 0.1503
Loa Loa (eye worm) hypothetical protein 0.0296 0.2508 0.6253
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0162
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0625 0.1549
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.1613
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0051 0.0202
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0242 0.2897
Brugia malayi hypothetical protein 0.0296 0.2508 0.6253
Echinococcus granulosus cpg binding protein 0.0061 0.0455 0.1128
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0496 0.123
Onchocerca volvulus 0.0016 0.0065 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0165
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1503 0.5734

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) 0 nM Displacement of clonidine from Alpha-2 adrenergic receptor of rat brain cortex ChEMBL. 9703460
Ki (binding) > 10000 nM Binding affinity towards Alpha-1 adrenergic receptor measured by displacement of [3H]-prazosin from rat brain cortex membranes ChEMBL. 9703460
Ki (binding) > 10000 nM Binding affinity towards Alpha-1 adrenergic receptor measured by displacement of [3H]-prazosin from rat brain cortex membranes ChEMBL. 9703460
Ratio (binding) 0 Relative affinity for alpha2 and alpha1 adrenergic receptors ChEMBL. 9703460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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