Detailed information for compound 1790223

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 510.509 | Formula: C23H29F3N6O4
  • H donors: 1 H acceptors: 4 LogP: 3.59 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)N1CCN(CC1)c1ccc(cn1)NC(=O)c1oc(nc1C(F)(F)F)N1CCC(CC1)C
  • InChi: 1S/C23H29F3N6O4/c1-3-35-22(34)32-12-10-30(11-13-32)17-5-4-16(14-27-17)28-20(33)18-19(23(24,25)26)29-21(36-18)31-8-6-15(2)7-9-31/h4-5,14-15H,3,6-13H2,1-2H3,(H,28,33)
  • InChiKey: WHRGYIPAFPBVLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens diacylglycerol O-acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Neospora caninum diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Theileria parva diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium falciparum diacylglycerol O-acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma mansoni diacylglycerol O-acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Brugia malayi diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium vivax diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128200 All targets in OG5_128200
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium yoelii acyl transferase-related Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium berghei diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Neospora caninum sterol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus granulosus diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium hominis acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium knowlesi diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus multilocularis diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium parvum diacylglycerol acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Babesia bovis diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0132 0.0345
Schistosoma mansoni biogenic amine (5HT) receptor 0.0544 0.4332 0.4324
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0544 0.4332 0.4324
Loa Loa (eye worm) matrixin family protein 0.0138 0.1042 0.1116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Echinococcus granulosus biogenic amine 5HT receptor 0.0544 0.4332 0.4329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0069 0.0481 0.0467
Schistosoma mansoni myosin xvIII 0.0544 0.4332 0.4324
Loa Loa (eye worm) hypothetical protein 0.0097 0.0707 0.0756
Schistosoma mansoni biogenic amine receptor 0.0544 0.4332 0.4324
Brugia malayi Matrixin family protein 0.0062 0.0428 0.0958
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0014
Onchocerca volvulus 0.0088 0.0638 0.1287
Entamoeba histolytica hypothetical protein 0.0026 0.0132 0.1872
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0074 0.0141
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0033 0.0282
Onchocerca volvulus 0.0544 0.4332 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus neuropeptide FF receptor 2 0.0544 0.4332 0.4329
Echinococcus granulosus neuropeptide receptor A26 0.0544 0.4332 0.4329
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Schistosoma mansoni biogenic amine (5HT) receptor 0.0544 0.4332 0.4324
Schistosoma mansoni opsin-like receptor 0.0544 0.4332 0.4324
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0097 0.0707 1
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0097 0.0707 1
Schistosoma mansoni neuropeptide F-like receptor 0.0544 0.4332 0.4324
Echinococcus granulosus rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Echinococcus granulosus allatostatin A receptor 0.0544 0.4332 0.4329
Entamoeba histolytica deoxycytidyl transferase, putative 0.0027 0.0139 0.1972
Brugia malayi Hemopexin family protein 0.0088 0.0638 0.1446
Loa Loa (eye worm) TYRA-2 protein 0.0544 0.4332 0.4648
Echinococcus multilocularis G protein coupled receptor 139 0.0544 0.4332 0.4329
Onchocerca volvulus 0.0064 0.0443 0.0826
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Trypanosoma brucei unspecified product 0.0018 0.0072 0.0586
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0544 0.4332 0.4648
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0132 0.014
Echinococcus multilocularis g protein coupled receptor 0.0544 0.4332 0.4329
Schistosoma mansoni terminal deoxycytidyl transferase 0.0027 0.0139 0.0124
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0097 0.0707 0.5947
Echinococcus multilocularis g-protein coupled receptor 0.0544 0.4332 0.4329
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0097 0.0707 1
Echinococcus granulosus intermediate filament protein 0.0021 0.0093 0.0088
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0132 0.0117
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0132 1
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0097 0.0707 0.1448
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0074 0.0068
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Schistosoma mansoni amine GPCR 0.0544 0.4332 0.4324
Echinococcus multilocularis dna polymerase kappa 0.0027 0.0139 0.0134
Onchocerca volvulus 0.0544 0.4332 1
Onchocerca volvulus 0.0544 0.4332 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0544 0.4332 0.4324
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus fmrfamide receptor 0.0544 0.4332 0.4329
Brugia malayi larval opioid receptor 0.0544 0.4332 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.0139 0.0125
Echinococcus multilocularis neuropeptides capa receptor 0.0544 0.4332 0.4329
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0097 0.0707 0.1604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0069 0.0481 0.0467
Schistosoma mansoni biogenic amine receptor 0.0544 0.4332 0.4324
Echinococcus granulosus rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Echinococcus multilocularis serotonin receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0544 0.4332 0.4329
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0093 0.0097
Brugia malayi intermediate filament protein 0.0021 0.0093 0.0182
Onchocerca volvulus 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0301 0.0321
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0132 0.1476
Trypanosoma cruzi DNA polymerase eta, putative 0.0027 0.0139 0.1581
Onchocerca volvulus 0.0544 0.4332 1
Loa Loa (eye worm) RecQ helicase 0.0019 0.0074 0.0077
Schistosoma mansoni neuropeptide receptor 0.0544 0.4332 0.4324
Loa Loa (eye worm) hypothetical protein 0.0062 0.0428 0.0457
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0128
Onchocerca volvulus 0.0047 0.0301 0.049
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus geminin 0.0122 0.0909 0.0904
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0097 0.0707 0.0792
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0109 0.0804 0.0799
Echinococcus granulosus rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0132 0.0117
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0544 0.4332 0.4329
Schistosoma mansoni ap endonuclease 0.0013 0.0033 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis fmrfamide receptor 0.0544 0.4332 0.4329
Echinococcus granulosus G protein coupled receptor 139 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Trichomonas vaginalis set domain proteins, putative 0.037 0.2917 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0072 0.0586
Brugia malayi Hhat protein 0.0026 0.0132 0.0273
Onchocerca volvulus 0.0544 0.4332 1
Onchocerca volvulus 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus multilocularis lamin 0.0021 0.0093 0.0088
Schistosoma mansoni opsin-like receptor 0.0544 0.4332 0.4324
Echinococcus granulosus sterol O acyltransferase 1 0.0026 0.0132 0.0127
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0122 0.0249
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Brugia malayi hypothetical protein 0.0544 0.4332 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0109 0.0804 0.0907
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0097 0.0707 1
Schistosoma mansoni hypothetical protein 0.0122 0.0909 0.0895
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0015 0.0014
Schistosoma mansoni DNA polymerase eta 0.0027 0.0139 0.0124
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0544 0.4332 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0544 0.4332 1
Echinococcus granulosus somatostatin receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0097 0.0707 0.0702
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0109 0.0804 1
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0132 0.014
Schistosoma mansoni hypothetical protein 0.0064 0.0443 0.0428
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0074 0.0605
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.014
Leishmania major glycerol uptake protein, putative 0.0026 0.0132 0.1289
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus multilocularis fmrfamide receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0544 0.4332 0.4329
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0076 0.0538 0.1212
Trichomonas vaginalis porcupine, putative 0.0026 0.0132 0.0345
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0132 0.1476
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0544 0.4332 0.4324
Onchocerca volvulus 0.037 0.2917 0.6662
Leishmania major hypothetical protein, conserved 0.0026 0.0132 0.1289
Onchocerca volvulus 0.0544 0.4332 1
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0097 0.0707 1
Schistosoma mansoni adenoreceptor 0.0544 0.4332 0.4324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0301 0.0286
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0544 0.4332 0.4324
Brugia malayi Serotonin receptor 0.0544 0.4332 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0544 0.4332 0.4324
Loa Loa (eye worm) hypothetical protein 0.0314 0.2469 0.2648
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0132 0.1872
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Brugia malayi MBOAT family protein 0.0026 0.0132 0.0273
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0097 0.0707 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Brugia malayi RE15519p 0.0544 0.4332 1
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0097 0.0707 1
Schistosoma mansoni amine GPCR 0.0544 0.4332 0.4324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0226 0.1757 0.1752
Schistosoma mansoni hypothetical protein 0.0122 0.0909 0.0895
Brugia malayi Pre-SET motif family protein 0.0325 0.2554 0.5881
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0027 0.0139 0.0124
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0132 0.014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0047 0.0301 0.0296
Brugia malayi MBOAT family protein 0.0026 0.0132 0.0273
Brugia malayi G protein-coupled receptor F59B2.13 0.0544 0.4332 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0062 0.0428 0.0413
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0132 0.1872
Onchocerca volvulus Matrilysin homolog 0.0062 0.0428 0.079
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0074 0.0068
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0153 0.1166 0.1161
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0544 0.4332 0.4329
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0074 0.0138
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0074 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.014
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus multilocularis neuropeptide receptor A26 0.0544 0.4332 0.4329
Brugia malayi Dopamine receptor protein 2 0.0544 0.4332 1
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0097 0.0707 0.0726
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Schistosoma mansoni aldehyde dehydrogenase 0.0109 0.0804 0.079
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0132 0.0345
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0153 0.1166 0.1152
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0033 0.0028
Onchocerca volvulus 0.0544 0.4332 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0015 0.0002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0544 0.4332 0.4329
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0132 0.0127
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0132 0.0127
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Onchocerca volvulus 0.0544 0.4332 1
Echinococcus granulosus neuropeptide receptor 0.0544 0.4332 0.4329
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0139 0.1581
Echinococcus granulosus orexin receptor type 2 0.0544 0.4332 0.4329
Trypanosoma brucei DNA polymerase eta, putative 0.0027 0.0139 0.1581
Echinococcus granulosus tm gpcr rhodopsin 0.0544 0.4332 0.4329
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0544 0.4332 0.4324
Onchocerca volvulus 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.009 0.0094
Loa Loa (eye worm) G-protein coupled receptor 0.0544 0.4332 0.4648
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0097 0.0707 0.0726
Brugia malayi hypothetical protein 0.0544 0.4332 1
Schistosoma mansoni NAD dehydrogenase 0.0097 0.0707 0.0692
Echinococcus granulosus rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Schistosoma mansoni alpha-1 adrenergic receptor 0.0544 0.4332 0.4324
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0544 0.4332 0.4329
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0097 0.0707 0.0692
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0544 0.4332 0.4324
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0072 0.0586
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0139 0.1581
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0093 0.0097
Chlamydia trachomatis D-amino acid dehydrogenase 0.0097 0.0707 0.5
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0097 0.0707 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0544 0.4332 0.4324
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0132 0.0127
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0074 0.0631
Echinococcus granulosus rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Schistosoma mansoni neuropeptide f receptor 76f 0.0544 0.4332 0.4324
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0544 0.4332 0.4329
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0544 0.4332 0.4329
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0011 0.0015 0.001
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0027 0.0139 0.0125
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0097 0.0707 0.0702
Echinococcus multilocularis sex peptide receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Loa Loa (eye worm) matrixin family protein 0.015 0.1143 0.1224
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0097 0.0707 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0132 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Loa Loa (eye worm) matrix metalloproteinase 0.0062 0.0428 0.0457
Brugia malayi sulfakinin receptor protein 0.0544 0.4332 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0045 0.0287 0.0282
Echinococcus granulosus neuropeptides capa receptor 0.0544 0.4332 0.4329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0301 0.0286
Brugia malayi hypothetical protein 0.0544 0.4332 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0069 0.0481 0.0476
Onchocerca volvulus 0.0062 0.0428 0.079
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0097 0.0707 0.0726
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0097 0.0707 0.1604
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0132 0.0127
Brugia malayi Melatonin receptor type 1A 0.0544 0.4332 1
Echinococcus multilocularis neuropeptide Y receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis orexin receptor type 2 0.0544 0.4332 0.4329
Brugia malayi ImpB/MucB/SamB family protein 0.0027 0.0139 0.029
Echinococcus granulosus g protein coupled receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0074 0.0068
Brugia malayi G-protein coupled receptor 0.0544 0.4332 1
Schistosoma mansoni neuropeptide receptor 0.0544 0.4332 0.4324
Mycobacterium ulcerans D-amino acid oxidase Aao 0.116 0.9318 1
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0015 0.0002
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0033 0.0191 0.0176
Trypanosoma brucei unspecified product 0.0018 0.0072 0.0586
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.1063 0.8535 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0064 0.0443 0.0993
Echinococcus granulosus rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0033 0.0033
Brugia malayi hypothetical protein 0.0544 0.4332 1
Echinococcus multilocularis musashi 0.0021 0.0093 0.0088
Schistosoma mansoni lamin 0.0021 0.0093 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0109 0.0804 0.0799
Brugia malayi Matrixin family protein 0.0062 0.0428 0.0958
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0097 0.0707 0.1448
Onchocerca volvulus 0.0544 0.4332 1
Echinococcus granulosus bloom syndrome protein 0.0019 0.0074 0.0068
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus multilocularis geminin 0.0122 0.0909 0.0904
Schistosoma mansoni hypothetical protein 0.0544 0.4332 0.4324
Brugia malayi cDNA sequence BC016226 0.0097 0.0707 0.1604
Schistosoma mansoni hypothetical protein 0.0544 0.4332 0.4324
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0097 0.0707 0.6061
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus multilocularis g protein coupled receptor 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0076 0.0538 0.0575
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0544 0.4332 0.4329
Echinococcus multilocularis neuropeptide receptor 0.0544 0.4332 0.4329
Leishmania major glycerol uptake protein, putative 0.0026 0.0132 0.1289
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.116 0.9318 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0707 0.0756
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0147
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0074 0.0068
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0047 0.0301 0.258
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0077
Schistosoma mansoni survival motor neuron protein 0.0064 0.0443 0.0428
Onchocerca volvulus 0.0544 0.4332 1
Schistosoma mansoni fad oxidoreductase 0.0097 0.0707 0.0692
Echinococcus multilocularis sterol O acyltransferase 1 0.0026 0.0132 0.0127
Schistosoma mansoni DNA helicase recq1 0.0019 0.0074 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0033 0.0028
Leishmania major glycerol uptake protein, putative 0.0026 0.0132 0.1289
Echinococcus granulosus hypothetical protein 0.0544 0.4332 0.4329
Plasmodium vivax SET domain protein, putative 0.0047 0.0301 0.258
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.0015 0.001
Echinococcus granulosus neuropeptide receptor 0.0544 0.4332 0.4329
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0074 0.0141
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0097 0.0707 1
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0132 0.0127
Loa Loa (eye worm) hhat protein 0.0026 0.0132 0.014
Toxoplasma gondii exonuclease III APE 0.0013 0.0033 0.0282
Leishmania major hypothetical protein, conserved 0.0097 0.0707 0.8734
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0544 0.4332 0.4324
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0069 0.0481 0.0514
Schistosoma mansoni intermediate filament proteins 0.0021 0.0093 0.0078
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0097 0.0707 0.0692
Echinococcus granulosus alpha 1A adrenergic receptor 0.0544 0.4332 0.4329
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0033 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0011 0.0015 0.001
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0132 0.0117
Giardia lamblia DINP protein human, muc B family 0.0027 0.0139 0.1581
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0097 0.0707 0.0756
Schistosoma mansoni hypothetical protein 0.0088 0.0638 0.0624
Echinococcus granulosus tachykinin peptides receptor 99D 0.0544 0.4332 0.4329
Echinococcus granulosus g protein coupled receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0544 0.4332 0.4329
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0097 0.0707 0.8734
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0027 0.0139 0.0134
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0544 0.4332 0.4648
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0074 0.036
Schistosoma mansoni ap endonuclease 0.0013 0.0033 0.0018
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0544 0.4332 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0069 0.0481 0.1081
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0097 0.0707 0.0726
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0544 0.4332 0.4648
Brugia malayi neuropeptide F receptor 0.0544 0.4332 1
Echinococcus granulosus dna polymerase kappa 0.0027 0.0139 0.0134
Brugia malayi diacylglycerol acyltransferase 0.0153 0.1166 0.2667
Leishmania major glycerol uptake protein, putative 0.0026 0.0132 0.1289
Echinococcus multilocularis neuropeptide Y receptor 0.0544 0.4332 0.4329
Echinococcus granulosus lamin 0.0021 0.0093 0.0088
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0132 0.1476
Onchocerca volvulus 0.0544 0.4332 1
Brugia malayi G protein-coupled receptor 0.0544 0.4332 1
Echinococcus multilocularis allatostatin A receptor 0.0544 0.4332 0.4329
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0132 0.0117
Leishmania major DNA polymerase kappa, putative 0.0027 0.0139 0.1381
Schistosoma mansoni biogenic amine receptor 0.0544 0.4332 0.4324
Echinococcus multilocularis neuropeptide s receptor 0.0544 0.4332 0.4329
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0153 0.1166 0.1249
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.116 0.9318 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0074 0.0138
Echinococcus granulosus neuropeptide s receptor 0.0544 0.4332 0.4329
Schistosoma mansoni d-amino acid oxidase 0.116 0.9318 0.9317
Leishmania major hypothetical protein, conserved 0.0097 0.0707 0.8734
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.014
Echinococcus multilocularis G-protein coupled receptor, putative 0.0544 0.4332 0.4329
Echinococcus granulosus sex peptide receptor 0.0544 0.4332 0.4329
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0544 0.4332 0.4324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) neuropeptide F receptor 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0132 0.0127
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0132 0.0127
Schistosoma mansoni amine GPCR 0.0544 0.4332 0.4324
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0076 0.0538 0.0594
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0132 0.0117
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0544 0.4332 0.4648
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0074 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0036 0.0213 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Brugia malayi MBOAT family protein 0.0026 0.0132 0.0273
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0683 0.5456 0.5453
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0544 0.4332 0.4329
Echinococcus granulosus neuropeptide Y receptor 0.0544 0.4332 0.4329
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0139 0.1581
Loa Loa (eye worm) melatonin receptor type 1A 0.0544 0.4332 0.4648
Brugia malayi hypothetical protein 0.0314 0.2469 0.5686
Echinococcus granulosus survival motor neuron protein 1 0.0314 0.2469 0.2466
Onchocerca volvulus Matrix metalloproteinase homolog 0.0138 0.1042 0.2238
Echinococcus multilocularis microtubule associated protein 2 0.1244 1 1
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0132 0.1872
Echinococcus multilocularis dro:myosuppressin receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0132 0.0127
Mycobacterium ulcerans DNA polymerase IV 0.0027 0.0139 0.0115
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0093 0.0182
Onchocerca volvulus Neuropeptide F receptor homolog 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0428 0.0457
Echinococcus multilocularis neuropeptide receptor 0.0544 0.4332 0.4329
Schistosoma mansoni hypothetical protein 0.0026 0.0132 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Echinococcus multilocularis lamin dm0 0.0021 0.0093 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0301 0.0286
Toxoplasma gondii aldehyde dehydrogenase 0.0109 0.0804 0.6899
Brugia malayi putative neuropeptide receptor NPR1 0.0544 0.4332 1
Brugia malayi AKH receptor 0.0544 0.4332 1
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0153 0.1166 0.1161
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0027 0.0139 0.0134
Echinococcus multilocularis dna polymerase eta 0.0027 0.0139 0.0134
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0544 0.4332 0.4329
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0132 0.0345
Echinococcus multilocularis g protein coupled receptor 0.0544 0.4332 0.4329
Mycobacterium ulcerans DNA polymerase IV 0.0027 0.0139 0.0115
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0074 0.0605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0069 0.0481 0.0467
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0036 0.0213 0.0461
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.014
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0074 0.1042
Echinococcus granulosus GPCR family 2 0.0011 0.0015 0.001
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0132 0.1872
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0097 0.0707 0.0702
Brugia malayi hypothetical protein 0.0544 0.4332 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0132 0.1476
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0132 0.0127
Schistosoma mansoni DNA helicase recq5 0.0019 0.0074 0.0058
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0544 0.4332 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0325 0.2554 0.2739
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0074 0.0631
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0132 0.1872
Mycobacterium ulcerans aldehyde dehydrogenase 0.0109 0.0804 0.0831
Trichomonas vaginalis DNA polymerase eta, putative 0.0027 0.0139 0.0369
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0544 0.4332 0.4329
Loa Loa (eye worm) hhat protein 0.0026 0.0132 0.014
Brugia malayi Matrixin family protein 0.015 0.1143 0.2613
Brugia malayi MBOAT family protein 0.0026 0.0132 0.0273
Loa Loa (eye worm) hypothetical protein 0.0062 0.0428 0.0457
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0153 0.1166 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Trypanosoma brucei unspecified product 0.0027 0.0139 0.1581
Onchocerca volvulus 0.0544 0.4332 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0544 0.4332 0.4329
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0074 0.036
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0132 0.0127
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0097 0.0707 0.6061
Echinococcus granulosus dna polymerase eta 0.0027 0.0139 0.0134
Brugia malayi Matrixin family protein 0.0062 0.0428 0.0958
Echinococcus granulosus biogenic amine 5HT receptor 0.0544 0.4332 0.4329
Loa Loa (eye worm) neuropeptide F receptor 0.0544 0.4332 0.4648
Leishmania major glycerol uptake protein, putative 0.0026 0.0132 0.1289
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0153 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Brugia malayi hypothetical protein 0.0544 0.4332 1
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0132 0.014
Schistosoma mansoni microtubule-associated protein tau 0.1244 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0003
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0544 0.4332 0.4324
Schistosoma mansoni hypothetical protein 0.0544 0.4332 0.4324
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0132 0.0127
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0027 0.0139 0.0147
Brugia malayi Dopamine receptor protein 1 0.0544 0.4332 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0069 0.0481 0.0476
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0544 0.4332 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Toxoplasma gondii hypothetical protein 0.0026 0.0132 0.1135
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Onchocerca volvulus 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus serotonin receptor 0.0544 0.4332 0.4329
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0013 0.0033 0.5
Schistosoma mansoni amine GPCR 0.0544 0.4332 0.4324
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0097 0.0707 0.0192
Schistosoma mansoni opsin-like receptor 0.0544 0.4332 0.4324
Schistosoma mansoni growth hormone secretagogue receptor 0.0544 0.4332 0.4324
Brugia malayi Matrixin family protein 0.0062 0.0428 0.0958
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0301 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0301 0.0286
Schistosoma mansoni aldehyde dehydrogenase 0.0109 0.0804 0.079
Echinococcus granulosus neuropeptides capa receptor 0.0544 0.4332 0.4329
Echinococcus granulosus tm gpcr rhodopsin 0.0544 0.4332 0.4329
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0544 0.4332 0.4324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Echinococcus multilocularis GPCR, family 2 0.0011 0.0015 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0074 0.0068
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0707 0.0756
Schistosoma mansoni neuropeptide receptor 0.0544 0.4332 0.4324
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Schistosoma mansoni fad oxidoreductase 0.0097 0.0707 0.0692
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0097 0.0707 1
Loa Loa (eye worm) G-protein coupled receptor 0.0544 0.4332 0.4648
Schistosoma mansoni lamin 0.0021 0.0093 0.0078
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Brugia malayi hypothetical protein 0.0544 0.4332 1
Brugia malayi Serotonin receptor 0.0544 0.4332 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0027 0.0139 0.1381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.0015 0.001
Leishmania major DNA polymerase eta, putative 0.0027 0.0139 0.1381
Brugia malayi hypothetical protein 0.0544 0.4332 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Onchocerca volvulus 0.0026 0.0132 0.0093
Onchocerca volvulus 0.0544 0.4332 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0132 0.0127
Trypanosoma cruzi GUP1, putative 0.0026 0.0132 0.1476
Trypanosoma cruzi GUP1, putative 0.0026 0.0132 0.1476
Onchocerca volvulus Matrilysin homolog 0.0138 0.1042 0.2238
Schistosoma mansoni histamine h1 receptor 0.0544 0.4332 0.4324
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0074 0.0141
Mycobacterium ulcerans hydrolase 0.0076 0.0538 0.0544
Echinococcus granulosus lamin dm0 0.0021 0.0093 0.0088
Echinococcus multilocularis neuropeptide FF receptor 2 0.0544 0.4332 0.4329
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0074 0.0529
Brugia malayi neuropeptide F receptor 0.0544 0.4332 1
Brugia malayi Dopamine receptor 0.0544 0.4332 1
Schistosoma mansoni zinc finger protein 0.0026 0.0132 0.0117
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0097 0.0707 0.0702
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Brugia malayi ImpB/MucB/SamB family protein 0.0027 0.0139 0.029
Echinococcus granulosus peptide allatostatin:somatostatin 0.0544 0.4332 0.4329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0109 0.0804 0.0831
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0544 0.4332 0.4324
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0097 0.0707 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0544 0.4332 0.4329
Brugia malayi follicle stimulating hormone receptor 0.0544 0.4332 1
Echinococcus multilocularis somatostatin receptor 0.0544 0.4332 0.4329
Schistosoma mansoni hypothetical protein 0.0544 0.4332 0.4324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0213 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0132 0.0345
Brugia malayi RE18450p 0.0097 0.0707 0.1604
Schistosoma mansoni sterol O-acyltransferase 1 0.0026 0.0132 0.0117
Brugia malayi Pre-SET motif family protein 0.0047 0.0301 0.0664
Echinococcus granulosus dro:myosuppressin receptor 0.0544 0.4332 0.4329
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0132 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0069 0.0481 0.0476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0097 0.0707 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0544 0.4332 0.4648
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0013 0.0033 0.0465
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0027 0.0139 0.0369
Mycobacterium ulcerans aldehyde dehydrogenase 0.0109 0.0804 0.0831
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0153 0.1166 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0097 0.0707 1
Brugia malayi hypothetical protein 0.0544 0.4332 1
Toxoplasma gondii hypothetical protein 0.0097 0.0707 0.6061
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus g protein coupled receptor 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Brugia malayi G-protein coupled receptor 0.0544 0.4332 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0544 0.4332 0.4329
Loa Loa (eye worm) hypothetical protein 0.0128 0.0957 0.1025
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0132 0.1476
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Loa Loa (eye worm) hypothetical protein 0.0544 0.4332 0.4648
Echinococcus granulosus 7TM GPCR rhodopsin 0.0544 0.4332 0.4329
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0097 0.0707 0.0192
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0544 0.4332 0.4329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0069 0.0481 0.0476
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0153 0.1166 1
Schistosoma mansoni neuropeptide F-like receptor 0.0544 0.4332 0.4324
Echinococcus granulosus tm gpcr rhodopsin 0.0544 0.4332 0.4329
Echinococcus granulosus rhodopsin orphan GPCR 0.0544 0.4332 0.4329
Brugia malayi hypothetical protein 0.0544 0.4332 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Schistosoma mansoni amine GPCR 0.0544 0.4332 0.4324
Brugia malayi ORL1-like opioid receptor 0.0544 0.4332 1
Echinococcus multilocularis serotonin receptor 0.0544 0.4332 0.4329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0544 0.4332 0.4324
Schistosoma mansoni hypothetical protein 0.0024 0.0122 0.0107
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0097 0.0707 1
Brugia malayi GnHR receptor homolog 0.0544 0.4332 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0301 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.1581
Brugia malayi Calcitonin receptor-like protein seb-1 0.0036 0.0213 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0072 0.0586
Brugia malayi putative neuropeptide receptor 0.0544 0.4332 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0074 0.0605
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0226 0.1757 0.1752
Brugia malayi MBOAT family protein 0.0026 0.0132 0.0273
Onchocerca volvulus Putative fad oxidoreductase 0.0097 0.0707 0.1448
Schistosoma mansoni neuropeptide receptor 0.0544 0.4332 0.4324
Echinococcus granulosus g-protein coupled receptor 0.0544 0.4332 0.4329
Echinococcus multilocularis survival motor neuron protein 1 0.0314 0.2469 0.2466
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0139 0.1581

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 228 nM Inhibition of human DGAT-1 expressed in insect Sf9 cell microsomes using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA as substrate after 2 hrs ChEMBL. 24120540

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.