TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 553.499 | Formula: C26H25F6N5O2
H donors: 1 H acceptors: 4 LogP: 6.08 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCn1nnc(n1)C1=C(CC(NC1=O)(c1ccc(cc1)OCCCC(F)(F)F)C(F)(F)F)c1ccc(cc1)C
InChi: 1S/C26H25F6N5O2/c1-3-37-35-22(34-36-37)21-20(17-7-5-16(2)6-8-17)15-24(26(30,31)32,33-23(21)38)18-9-11-19(12-10-18)39-14-4-13-25(27,28)29/h5-12H,3-4,13-15H2,1-2H3,(H,33,38)
InChiKey: YTDRWNDMSGPTFZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	monoacylglycerol O-acyltransferase 2	Starlite/ChEMBL	References
Homo sapiens	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_127120	All targets in OG5_127120
Leishmania braziliensis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Candida albicans	similar to diacylglycerol acyltransferase type 2B	Get druggable targets OG5_127120	All targets in OG5_127120
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133242	All targets in OG5_133242
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	Get druggable targets OG5_133242	All targets in OG5_133242
Candida albicans	similar to diacylglycerol acyltransferase type 2B	Get druggable targets OG5_127120	All targets in OG5_127120
Schistosoma japonicum	2-acylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Cryptosporidium parvum	hypothetical protein with 4 transmembrane domains	Get druggable targets OG5_127120	All targets in OG5_127120
Leishmania donovani	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_127120	All targets in OG5_127120
Trypanosoma congolense	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_127120	All targets in OG5_127120
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Schistosoma japonicum	2-acylglycerol O-acyltransferase 2-A, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Onchocerca volvulus		Get druggable targets OG5_127120	All targets in OG5_127120
Trypanosoma brucei gambiense	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_127120	All targets in OG5_127120
Leishmania infantum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Brugia malayi	UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II	Get druggable targets OG5_133242	All targets in OG5_133242
Trypanosoma brucei	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	Get druggable targets OG5_133242	All targets in OG5_133242
Schistosoma japonicum	ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative	Get druggable targets OG5_133242	All targets in OG5_133242
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	Get druggable targets OG5_133242	All targets in OG5_133242
Leishmania major	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Brugia malayi	diacylglycerol acyltransferase family protein	Get druggable targets OG5_127120	All targets in OG5_127120
Toxoplasma gondii	dgat2l1-prov protein	Get druggable targets OG5_127120	All targets in OG5_127120
Neospora caninum	Diacylglycerol acyl transferase, related	Get druggable targets OG5_127120	All targets in OG5_127120

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	diacylglycerol acyltransferase, putative	monoacylglycerol O-acyltransferase 2	334 aa	297 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0098	0.0674	0.1435
Echinococcus multilocularis	General substrate transporter	0.0089	0.0602	0.0659
Schistosoma mansoni	hypothetical protein	0.0034	0.0136	0.0126
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.0725	0.0795
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0047	0.0036
Brugia malayi	MH2 domain containing protein	0.0115	0.082	0.0776
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.012	0.0863	0.0853
Echinococcus granulosus	GPCR family 2	0.0034	0.0136	0.014
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0141	0.013
Loa Loa (eye worm)	sugar transporter	0.0104	0.0725	0.0715
Echinococcus granulosus	expressed protein	0.012	0.0863	0.0949
Echinococcus granulosus	regulator of G protein signaling 3	0.012	0.0863	0.0949
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0157	0.0264
Echinococcus multilocularis	axis inhibition protein axin	0.012	0.0863	0.0949
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0171	0.1287	0.2667
Leishmania major	pyruvate kinase	0.0576	0.4697	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Entamoeba histolytica	hypothetical protein	0.012	0.0863	0.2562
Brugia malayi	beta-lactamase	0.0034	0.0141	0.0094
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.0725	0.0795
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0047	0.0027
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.0409	0.0443
Brugia malayi	PXA domain containing protein	0.012	0.0863	0.082
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0114	0.0115
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0144	0.0133
Mycobacterium tuberculosis	Probable lipase LipD	0.0034	0.0141	0.0263
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0022	0.0034	0.0073
Trypanosoma cruzi	hexose transporter	0.0032	0.0123	0.0261
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0114	0.0067
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0141	0.03
Leishmania major	pyruvate kinase	0.0576	0.4697	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.012	0.0863	0.0853
Echinococcus granulosus	pyruvate kinase	0.0296	0.2339	0.2593
Plasmodium falciparum	protein kinase 6	0.0444	0.3582	0.7602
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0576	0.4697	0.4672
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0144	0.0208
Brugia malayi	PXA domain containing protein	0.012	0.0863	0.082
Mycobacterium tuberculosis	Conserved protein	0.0034	0.0141	0.0263
Schistosoma mansoni	alkaline phosphatase	0.0157	0.1173	0.1163
Loa Loa (eye worm)	pyruvate kinase	0.0576	0.4697	0.4691
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0065	0.0054
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0442	0.0875
Echinococcus granulosus	geminin	0.0188	0.1433	0.1583
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0114	0.0103
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0123	0.0261
Echinococcus granulosus	alkaline phosphatase	0.0157	0.1173	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0114	0.0103
Schistosoma mansoni	axis inhibition protein axin	0.012	0.0863	0.0853
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0047	0.0027
Entamoeba histolytica	hypothetical protein	0.012	0.0863	0.2562
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0047	0.01
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0047	0.004
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0047	0.004
Schistosoma mansoni	pyruvate kinase	0.0576	0.4697	0.4691
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0144	0.0148
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0136	0.014
Loa Loa (eye worm)	pyruvate kinase	0.0121	0.0873	0.0863
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0123	0.0214
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Echinococcus multilocularis	regulator of G protein signaling 7	0.012	0.0863	0.0949
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0123	0.019
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0114	0.0103
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1087	0.8989	0.8988
Brugia malayi	Bromodomain containing protein	0.0083	0.0552	0.0507
Mycobacterium ulcerans	esterase/lipase LipP	0.0034	0.0141	0.0229
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0141	0.0252
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0034	0.0141	0.013
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.0433	0.3493	0.3878
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0141	0.0202
Entamoeba histolytica	protein kinase, putative	0.0035	0.0144	0.0304
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.0433	0.3493	0.3878
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0863	0.1797
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0141	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0047	0.0036
Trichomonas vaginalis	penicillin-binding protein, putative	0.0034	0.0141	0.0252
Echinococcus multilocularis	regulator of G protein signaling 3	0.012	0.0863	0.0949
Entamoeba histolytica	hypothetical protein	0.0187	0.1428	0.4336
Loa Loa (eye worm)	hypothetical protein	0.012	0.0863	0.0853
Schistosoma mansoni	hypothetical protein	0.0082	0.0538	0.0528
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0144	0.0097
Brugia malayi	PHD-finger family protein	0.0028	0.0084	0.0038
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0467	0.0422
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0034	0.0141	0.0263
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0136	0.014
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0144	0.0235
Echinococcus granulosus	General substrate transporter	0.0089	0.0602	0.0659
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0144	0.0133
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0123	0.019
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0136	0.014
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0022	0.0034	0.0073
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0144	0.0235
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0576	0.4697	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0576	0.4697	1
Schistosoma mansoni	axis inhibition protein axin	0.012	0.0863	0.0853
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0114	0.0211
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.007	0.0442	0.0875
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0034	0.0141	0.0263
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0022	0.0034	0.0023
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0123	0.0214
Mycobacterium tuberculosis	Probable esterase LipL	0.0034	0.0141	0.0263
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0103	0.0102
Schistosoma mansoni	serine/threonine protein kinase	0.0125	0.0904	0.0894
Brugia malayi	regulator of G-protein signaling rgs-7	0.012	0.0863	0.082
Schistosoma mansoni	regulator of G protein signaling	0.012	0.0863	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0467	0.0456
Onchocerca volvulus		0.0098	0.0674	0.1171
Brugia malayi	diacylglycerol acyltransferase family protein	0.0098	0.0674	0.063
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0103	0.0102
Brugia malayi	A-kinase anchor protein 10, precursor	0.012	0.0863	0.082
Brugia malayi	Cam kinase protein 1	0.0035	0.0144	0.0097
Schistosoma mansoni	hypothetical protein	0.0023	0.0044	0.0033
Leishmania major	glucose transporter, lmgt2	0.0032	0.0123	0.019
Trichomonas vaginalis	pyruvate kinase, putative	0.0576	0.4697	1
Leishmania major	diacylglycerol acyltransferase, putative	0.0098	0.0674	0.1373
Toxoplasma gondii	protein kinase, putative	0.0296	0.2343	0.4952
Schistosoma mansoni	regulator of G protein signaling	0.012	0.0863	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0141	0.013
Brugia malayi	Bromodomain containing protein	0.0042	0.0209	0.0163
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0123	0.0261
Echinococcus multilocularis	pyruvate kinase	0.0296	0.2339	0.2593
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0034	0.0141	0.0145
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.0725	0.0795
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0144	0.0258
Schistosoma mansoni	transcription factor LCR-F1	0.0187	0.1428	0.1418
Onchocerca volvulus	Pyruvate kinase homolog	0.0576	0.4697	1
Echinococcus multilocularis	alkaline phosphatase	0.0157	0.1173	0.1294
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0144	0.0208
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0442	0.0432
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0576	0.4697	1
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0863	0.1797
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0034	0.0141	0.0229
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0098	0.0674	0.0664
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0157	0.0264
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.0409	0.0443
Loa Loa (eye worm)	RGS-3 protein	0.012	0.0863	0.0853
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0123	0.019
Echinococcus granulosus	pyruvate kinase	0.0576	0.4697	0.522
Mycobacterium tuberculosis	Conserved protein	0.0034	0.0141	0.0263
Echinococcus multilocularis	zinc finger protein	0.0022	0.0035	0.0026
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.012	0.0863	0.0949
Trypanosoma brucei	pyruvate kinase 1, putative	0.0576	0.4697	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0141	0.0252
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.0725	0.1502
Brugia malayi	hypothetical protein	0.012	0.0863	0.082
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0576	0.4697	0.4672
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0125	0.0904	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0433	0.3493	0.3485
Toxoplasma gondii	pyruvate kinase PyK1	0.0576	0.4697	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0136	0.014
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.1087	0.8989	0.8988
Loa Loa (eye worm)	beta-lactamase	0.0034	0.0141	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0863	0.1797
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0144	0.0148
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.1087	0.8989	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0136	0.014
Brugia malayi	Regulator of G protein signaling domain containing protein	0.012	0.0863	0.082
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0034	0.0141	0.0263
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.012	0.0863	0.0949
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0157	0.1173	0.1294
Brugia malayi	Sugar transporter family protein	0.0104	0.0725	0.0681
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.0725	0.1482
Giardia lamblia	Pyruvate kinase	0.0296	0.2339	0.4929
Brugia malayi	UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II	0.0433	0.3493	0.3462
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0136	0.009
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0157	0.1173	0.1294
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Trypanosoma brucei	hypothetical protein, conserved	0.0034	0.0141	0.0229
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.082	0.0809
Schistosoma mansoni	hypothetical protein	0.0034	0.0136	0.0126
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0114	0.0144
Echinococcus multilocularis	pyruvate kinase	0.0576	0.4697	0.522
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.0751	0.0708
Loa Loa (eye worm)	hypothetical protein	0.012	0.0863	0.0853
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0157	0.1173	0.1294
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0144	0.0148
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0034	0.0141	0.0094
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.012	0.0863	0.0853
Schistosoma mansoni	hypothetical protein	0.0034	0.0136	0.0126
Chlamydia trachomatis	pyruvate kinase	0.0576	0.4697	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.1214	0.1204
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0442	0.0875
Loa Loa (eye worm)	pyruvate kinase	0.0576	0.4697	0.4691
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0157	0.1173	0.1294
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.0751	0.0708
Schistosoma mansoni	protein kinase	0.0035	0.0144	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0402	0.3231	0.3224
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0725	0.0795
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0442	0.0432
Schistosoma mansoni	hypothetical protein	0.0187	0.1428	0.1418
Schistosoma mansoni	hypothetical protein	0.0034	0.0136	0.0126
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0062	0.0057
Mycobacterium ulcerans	lipase LipD	0.0034	0.0141	0.0229
Echinococcus multilocularis	axis inhibition protein axin	0.012	0.0863	0.0949
Loa Loa (eye worm)	PXA domain-containing protein	0.012	0.0863	0.0853
Echinococcus granulosus	zinc finger protein	0.0022	0.0035	0.0026
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0144	0.0148
Trichomonas vaginalis	penicillin-binding protein, putative	0.0034	0.0141	0.0252
Schistosoma mansoni	glucose transport protein	0.0104	0.0725	0.0715
Schistosoma mansoni	regulator of G protein signaling	0.012	0.0863	0.0853
Toxoplasma gondii	ABC1 family protein	0.0034	0.0141	0.0229
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0047	0.0036
Brugia malayi	hypothetical protein	0.0187	0.1428	0.1387
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0144	0.0208
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0157	0.0335
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.007	0.0442	0.048
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0047	0.0027
Echinococcus granulosus	pyruvate kinase	0.0296	0.2339	0.2593
Brugia malayi	hypothetical protein	0.012	0.0863	0.082
Trypanosoma brucei	pyruvate kinase 1	0.0576	0.4697	1
Schistosoma mansoni	z-protein (S1r protein)	0.012	0.0863	0.0853
Schistosoma mansoni	protein kinase	0.0035	0.0144	0.0133
Echinococcus multilocularis	regulator of G protein signaling	0.012	0.0863	0.0949
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0136	0.0126
Echinococcus multilocularis	regulator of G protein signaling 7	0.012	0.0863	0.0949
Brugia malayi	regulator of G-protein signaling egl-10	0.012	0.0863	0.082
Schistosoma mansoni	bromodomain containing protein	0.007	0.0442	0.0432
Plasmodium vivax	hexose transporter	0.0104	0.0725	0.1458
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0123	0.0214
Plasmodium falciparum	protein kinase 7	0.0296	0.2343	0.4938
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0157	0.1173	0.1294
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0144	0.0235
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0144	0.0208
Entamoeba histolytica	pyruvate kinase, putative	0.0402	0.3231	1
Onchocerca volvulus		0.0162	0.1214	0.2355
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0141	0.013
Mycobacterium ulcerans	pyruvate kinase	0.0576	0.4697	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0136	0.009
Echinococcus multilocularis	pyruvate kinase	0.0576	0.4697	0.522
Plasmodium vivax	pyruvate kinase, putative	0.0576	0.4697	1
Schistosoma mansoni	glucose transport protein	0.0104	0.0725	0.0715
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.1087	0.8989	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0157	0.0238
Echinococcus granulosus	regulator of G protein signaling 3	0.012	0.0863	0.0949
Echinococcus multilocularis	pyruvate kinase	0.0296	0.2339	0.2593
Echinococcus granulosus	axis inhibition protein axin	0.012	0.0863	0.0949
Loa Loa (eye worm)	pyruvate kinase	0.0576	0.4697	0.4691
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0863	0.1797
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0144	0.0148
Plasmodium falciparum	pyruvate kinase 2	0.0296	0.2339	0.4929
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0047	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0141	0.03
Loa Loa (eye worm)	hypothetical protein	0.012	0.0863	0.0853
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0144	0.0208
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0047	0.0051
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0123	0.019
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0144	0.0133
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0098	0.0674	0.1373
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0725	0.0795
Schistosoma mansoni	hypothetical protein	0.0104	0.0725	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0576	0.4697	0.4691
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0157	0.0238
Echinococcus multilocularis	pyruvate kinase	0.0296	0.2339	0.2593
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0144	0.0148
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0123	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0123	0.0214
Mycobacterium tuberculosis	Probable hydrolase	0.0034	0.0141	0.0263
Mycobacterium ulcerans	beta-lactamase	0.0034	0.0141	0.0229
Loa Loa (eye worm)	hypothetical protein	0.012	0.0863	0.0853
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.012	0.0863	0.1797
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0782	0.6424	0.7142
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0125	0.0904	0.0994
Mycobacterium leprae	Probable lipase LipE	0.0034	0.0141	0.0263
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0044	0.0033
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.0751	0.0741
Loa Loa (eye worm)	pyruvate kinase-PB	0.0402	0.3231	0.3224
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0144	0.0208
Entamoeba histolytica	hypothetical protein	0.0187	0.1428	0.4336
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0171	0.1287	0.2667
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0022	0.0034	0.0073
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0157	0.0264
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0098	0.0674	0.1435
Giardia lamblia	Pyruvate kinase	0.0576	0.4697	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.007	0.0442	0.048
Brugia malayi	beta-lactamase family protein	0.0034	0.0141	0.0094
Echinococcus multilocularis	geminin	0.0188	0.1433	0.1583
Entamoeba histolytica	hypothetical protein	0.012	0.0863	0.2562
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0144	0.0208
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0062	0.0051
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0144	0.0148
Entamoeba histolytica	hypothetical protein	0.0187	0.1428	0.4336
Echinococcus granulosus	regulator of G protein signaling 7	0.012	0.0863	0.0949
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0022	0.0034	0.0073
Trichomonas vaginalis	esterase, putative	0.0034	0.0141	0.0252
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1087	0.8989	0.8985
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0141	0.013
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0114	0.0067
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0123	0.019
Plasmodium vivax	pyruvate kinase 2, putative	0.0296	0.2339	0.4929
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0123	0.019
Schistosoma mansoni	serine/threonine protein kinase	0.0125	0.0904	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0123	0.0214
Toxoplasma gondii	aldehyde dehydrogenase	0.007	0.0442	0.0875
Loa Loa (eye worm)	hypothetical protein	0.012	0.0863	0.0853
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0576	0.4697	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.021	0.0199
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0114	0.0206
Schistosoma mansoni	hypothetical protein	0.0022	0.0034	0.0023
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.012	0.0863	0.0853
Schistosoma mansoni	regulator of G protein signaling	0.012	0.0863	0.0853
Leishmania major	hypothetical protein, conserved	0.0034	0.0141	0.0229
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0174	0.1318	0.1277
Leishmania major	protein kinase, putative	0.0035	0.0144	0.0235
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0144	0.0148
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0114	0.0115
Brugia malayi	pyruvate kinase	0.0121	0.0873	0.083
Mycobacterium tuberculosis	Probable lipase LipE	0.0034	0.0141	0.0263
Schistosoma mansoni	hypothetical protein	0.0188	0.1433	0.1423
Entamoeba histolytica	protein kinase, putative	0.0035	0.0144	0.0304
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0123	0.019
Plasmodium falciparum	pyruvate kinase	0.0576	0.4697	1
Plasmodium falciparum	hexose transporter	0.0104	0.0725	0.1458
Mycobacterium tuberculosis	Conserved protein	0.0034	0.0141	0.0263
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0034	0.0141	0.013
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0114	0.0195
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0034	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0047	0.025	0.0239
Schistosoma mansoni	hypothetical protein	0.0073	0.0467	0.0456
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0157	0.1173	0.1294
Toxoplasma gondii	dgat2l1-prov protein	0.0098	0.0674	0.1373
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0144	0.0208
Schistosoma mansoni	pyruvate kinase	0.0576	0.4697	0.4691
Toxoplasma gondii	pyruvate kinase PyKII	0.0296	0.2339	0.4943
Echinococcus multilocularis	pyruvate kinase	0.0455	0.3676	0.4083
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.0433	0.3493	0.3485
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0187	0.1428	0.1578
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0125	0.0904	0.0894
Brugia malayi	pyruvate kinase, muscle isozyme	0.0121	0.0873	0.083
Entamoeba histolytica	hypothetical protein	0.0187	0.1428	0.4336
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0442	0.0875
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0219	0.1697	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0136	0.0126
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.082	0.0809
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.0725	0.0795
Leishmania major	glucose transporter, lmgt1	0.0032	0.0123	0.019
Schistosoma mansoni	alkaline phosphatase	0.0157	0.1173	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0114	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0141	0.013
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0187	0.0196
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0157	0.0335
Echinococcus multilocularis	Regulator of G protein signaling 20	0.012	0.0863	0.0949
Echinococcus granulosus	axis inhibition protein axin	0.012	0.0863	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0141	0.013
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0725	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0232	0.0221
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0444	0.3582	0.7602
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0062	0.0057
Loa Loa (eye worm)	hypothetical protein	0.012	0.0863	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0512	0.0501
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0144	0.0235
Schistosoma mansoni	zinc finger protein	0.0022	0.0035	0.0024
Schistosoma mansoni	regulator of G protein signaling	0.012	0.0863	0.0853
Schistosoma mansoni	hypothetical protein	0.0188	0.1433	0.1423
Onchocerca volvulus	Pyruvate kinase homolog	0.0576	0.4697	1
Echinococcus granulosus	pyruvate kinase	0.0576	0.4697	0.522
Schistosoma mansoni	pyruvate kinase	0.0296	0.2339	0.233
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1207	1	1
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0022	0.0034	0.0023
Leishmania major	glucose transporter, lmgt3	0.0032	0.0123	0.019
Echinococcus granulosus	beta LACTamase domain containing family member	0.0034	0.0141	0.0145
Schistosoma mansoni	serine/threonine protein kinase	0.1207	1	1
Brugia malayi	hypothetical protein	0.0162	0.1214	0.1172
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0187	0.1428	0.1578
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0187	0.0196
Schistosoma mansoni	glucose transport protein	0.0104	0.0725	0.0715
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0725	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0144	0.0133
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0047	0.0027
Brugia malayi	Regulator of G protein signaling domain containing protein	0.012	0.0863	0.082
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0751	0.0741
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0144	0.0208
Mycobacterium leprae	conserved hypothetical protein	0.0034	0.0141	0.0263
Mycobacterium ulcerans	hypothetical protein	0.0034	0.0141	0.0229
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0017	0.0006
Echinococcus multilocularis	expressed protein	0.012	0.0863	0.0949
Echinococcus multilocularis	regulator of G protein signaling 3	0.012	0.0863	0.0949
Schistosoma mansoni	protein kinase	0.0035	0.0144	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0863	0.1797
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0123	0.0261
Trichomonas vaginalis	pyruvate kinase, putative	0.0576	0.4697	1
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0098	0.0674	0.0664
Echinococcus granulosus	regulator of G protein signaling 7	0.012	0.0863	0.0949
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0863	0.1797
Echinococcus granulosus	Regulator of G protein signaling 20	0.012	0.0863	0.0949
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0123	0.0214
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.007	0.0442	0.0908
Onchocerca volvulus	Pyruvate kinase homolog	0.0576	0.4697	1
Brugia malayi	beta-lactamase family protein	0.0034	0.0141	0.0094
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0157	0.0264
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0047	0.0063
Echinococcus granulosus	pyruvate kinase	0.0296	0.2339	0.2593
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0171	0.1287	0.2687

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 121 nM	Inhibition of human MGAT2 by LC/MS assay	ChEMBL.	24900580
IC50 (binding)	= 121 nM	MGAT LCMS Assay	BINDINGDB.	No reference
IC50 (binding)	= 33330 nM	Inhibition of human MGAT2 by SPA assay	ChEMBL.	24900580
IC50 (binding)	= 33330 nM	MGAT SPA Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441599

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1792465