Detailed information for compound 1792465

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 553.499 | Formula: C26H25F6N5O2
  • H donors: 1 H acceptors: 4 LogP: 6.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCn1nnc(n1)C1=C(CC(NC1=O)(c1ccc(cc1)OCCCC(F)(F)F)C(F)(F)F)c1ccc(cc1)C
  • InChi: 1S/C26H25F6N5O2/c1-3-37-35-22(34-36-37)21-20(17-7-5-16(2)6-8-17)15-24(26(30,31)32,33-23(21)38)18-9-11-19(12-10-18)39-14-4-13-25(27,28)29/h5-12H,3-4,13-15H2,1-2H3,(H,33,38)
  • InChiKey: YTDRWNDMSGPTFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase No references
Homo sapiens monoacylglycerol O-acyltransferase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to diacylglycerol acyltransferase type 2B Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma mansoni diacylglycerol O-acyltransferase 1 Get druggable targets OG5_127120 All targets in OG5_127120
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133242 All targets in OG5_133242
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127120 All targets in OG5_127120
Trypanosoma cruzi diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma japonicum 2-acylglycerol O-acyltransferase 1, putative Get druggable targets OG5_127120 All targets in OG5_127120
Trypanosoma brucei diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Echinococcus granulosus alpha 16 mannosyl glycoprotein Get druggable targets OG5_133242 All targets in OG5_133242
Trypanosoma congolense diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Trypanosoma cruzi diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein Get druggable targets OG5_133242 All targets in OG5_133242
Trypanosoma brucei gambiense diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Loa Loa (eye worm) diacylglycerol acyltransferase Get druggable targets OG5_127120 All targets in OG5_127120
Candida albicans similar to diacylglycerol acyltransferase type 2B Get druggable targets OG5_127120 All targets in OG5_127120
Neospora caninum Diacylglycerol acyl transferase, related Get druggable targets OG5_127120 All targets in OG5_127120
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II Get druggable targets OG5_133242 All targets in OG5_133242
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II Get druggable targets OG5_133242 All targets in OG5_133242
Cryptosporidium parvum hypothetical protein with 4 transmembrane domains Get druggable targets OG5_127120 All targets in OG5_127120
Toxoplasma gondii dgat2l1-prov protein Get druggable targets OG5_127120 All targets in OG5_127120
Leishmania infantum diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Leishmania donovani diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Leishmania major diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Onchocerca volvulus Get druggable targets OG5_127120 All targets in OG5_127120
Leishmania braziliensis diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma japonicum 2-acylglycerol O-acyltransferase 2-A, putative Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma japonicum ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative Get druggable targets OG5_133242 All targets in OG5_133242
Brugia malayi diacylglycerol acyltransferase family protein Get druggable targets OG5_127120 All targets in OG5_127120
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major diacylglycerol acyltransferase, putative monoacylglycerol O-acyltransferase 2 334 aa 297 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0442 0.0875
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0114 0.0103
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0433 0.3493 0.3878
Echinococcus granulosus regulator of G protein signaling 3 0.012 0.0863 0.0949
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.012 0.0863 0.0853
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0023
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0098 0.0674 0.0664
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.0725 0.1482
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.1428 0.1578
Schistosoma mansoni serine/threonine protein kinase 0.1207 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0232 0.0221
Loa Loa (eye worm) hypothetical protein 0.012 0.0863 0.0853
Entamoeba histolytica pyruvate kinase, putative 0.0402 0.3231 1
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0022 0.0034 0.0023
Brugia malayi beta-lactamase family protein 0.0034 0.0141 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0467 0.0422
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0157 0.0264
Entamoeba histolytica protein kinase, putative 0.0035 0.0144 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0863 0.1797
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0044 0.0033
Echinococcus granulosus regulator of G protein signaling 7 0.012 0.0863 0.0949
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0047 0.0027
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0144 0.0133
Trypanosoma cruzi pyruvate kinase 2, putative 0.0576 0.4697 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.012 0.0863 0.0949
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0144 0.0235
Echinococcus granulosus regulator of G protein signaling 7 0.012 0.0863 0.0949
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0144 0.0148
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0141 0.0263
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.012 0.0863 0.0853
Schistosoma mansoni regulator of G protein signaling 0.012 0.0863 0.0853
Loa Loa (eye worm) hypothetical protein 0.0034 0.0141 0.013
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0098 0.0674 0.0664
Mycobacterium tuberculosis Conserved protein 0.0034 0.0141 0.0263
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0144 0.0148
Brugia malayi diacylglycerol acyltransferase family protein 0.0098 0.0674 0.063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0136 0.014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0409 0.0443
Leishmania major glucose transporter, lmgt2 0.0032 0.0123 0.019
Echinococcus multilocularis expressed protein 0.012 0.0863 0.0949
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0136 0.014
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0141 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0863 0.1797
Onchocerca volvulus Pyruvate kinase homolog 0.0576 0.4697 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0141 0.013
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0126
Echinococcus granulosus intestinal type alkaline phosphatase 0.0157 0.1173 0.1294
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0123 0.0261
Plasmodium falciparum protein kinase 6 0.0444 0.3582 0.7602
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0782 0.6424 0.7142
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0144 0.0208
Schistosoma mansoni hypothetical protein 0.0104 0.0725 0.0715
Loa Loa (eye worm) hypothetical protein 0.012 0.0863 0.0853
Schistosoma mansoni glucose transport protein 0.0104 0.0725 0.0715
Loa Loa (eye worm) hypothetical protein 0.0031 0.0114 0.0103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0133
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0751 0.0741
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0442 0.048
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0098 0.0674 0.1435
Entamoeba histolytica protein kinase, putative 0.0035 0.0144 0.0304
Chlamydia trachomatis pyruvate kinase 0.0576 0.4697 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0114 0.0206
Loa Loa (eye worm) sugar transporter 0.0104 0.0725 0.0715
Plasmodium falciparum pyruvate kinase 2 0.0296 0.2339 0.4929
Echinococcus granulosus expressed protein 0.012 0.0863 0.0949
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0157 0.1173 0.1294
Mycobacterium tuberculosis Conserved protein 0.0034 0.0141 0.0263
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0144 0.0208
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0144 0.0148
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0442 0.0432
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.1428 0.1578
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0144 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0863 0.1797
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 0.3582 0.7602
Brugia malayi hypothetical protein 0.0187 0.1428 0.1387
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.0725 0.0795
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0034 0.0073
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0174 0.1318 0.1277
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0047 0.0063
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0157 0.1173 0.1294
Giardia lamblia Pyruvate kinase 0.0576 0.4697 1
Mycobacterium ulcerans pyruvate kinase 0.0576 0.4697 1
Schistosoma mansoni alkaline phosphatase 0.0157 0.1173 0.1163
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0125 0.0904 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.0725 0.0795
Loa Loa (eye worm) hypothetical protein 0.0078 0.0512 0.0501
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0062 0.0051
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0047 0.0027
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0047 0.0051
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.012 0.0863 0.1797
Brugia malayi Pyruvate kinase, muscle isozyme 0.0576 0.4697 0.4672
Trypanosoma brucei pyruvate kinase 1, putative 0.0576 0.4697 1
Echinococcus multilocularis regulator of G protein signaling 3 0.012 0.0863 0.0949
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0141 0.0252
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0136 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0725 0.1502
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0442 0.0875
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0141 0.0202
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0144 0.0148
Echinococcus multilocularis pyruvate kinase 0.0455 0.3676 0.4083
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0098 0.0674 0.1435
Loa Loa (eye worm) RGS-3 protein 0.012 0.0863 0.0853
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.0725 0.0795
Toxoplasma gondii dgat2l1-prov protein 0.0098 0.0674 0.1373
Schistosoma mansoni hypothetical protein 0.0073 0.0467 0.0456
Entamoeba histolytica hypothetical protein 0.0187 0.1428 0.4336
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1207 1 1
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0103 0.0102
Loa Loa (eye worm) pyruvate kinase-PB 0.0402 0.3231 0.3224
Loa Loa (eye worm) hypothetical protein 0.0034 0.0141 0.013
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0144 0.0148
Loa Loa (eye worm) hypothetical protein 0.0034 0.0136 0.0126
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.1428 0.1418
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0141 0.03
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0157 0.0238
Onchocerca volvulus Pyruvate kinase homolog 0.0576 0.4697 1
Schistosoma mansoni glucose transport protein 0.0104 0.0725 0.0715
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0187 0.0196
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0123 0.019
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.0725 0.0795
Loa Loa (eye worm) hypothetical protein 0.0034 0.0141 0.013
Toxoplasma gondii ABC1 family protein 0.0034 0.0141 0.0229
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1087 0.8989 1
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0157 0.1173 0.1294
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0157 0.0264
Entamoeba histolytica hypothetical protein 0.012 0.0863 0.2562
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0141 0.0263
Echinococcus granulosus pyruvate kinase 0.0576 0.4697 0.522
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0144 0.0148
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0433 0.3493 0.3462
Brugia malayi pyruvate kinase, muscle isozyme 0.0121 0.0873 0.083
Trichomonas vaginalis pyruvate kinase, putative 0.0576 0.4697 1
Schistosoma mansoni regulator of G protein signaling 0.012 0.0863 0.0853
Echinococcus multilocularis axis inhibition protein axin 0.012 0.0863 0.0949
Schistosoma mansoni pyruvate kinase 0.0296 0.2339 0.233
Echinococcus multilocularis pyruvate kinase 0.0296 0.2339 0.2593
Onchocerca volvulus 0.0098 0.0674 0.1171
Brugia malayi PHD-finger family protein 0.0028 0.0084 0.0038
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0144 0.0235
Giardia lamblia Pyruvate kinase 0.0296 0.2339 0.4929
Leishmania major hypothetical protein, conserved 0.0034 0.0141 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0141 0.03
Loa Loa (eye worm) hypothetical protein 0.0107 0.0751 0.0741
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0114 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0123 0.0214
Brugia malayi Regulator of G protein signaling domain containing protein 0.012 0.0863 0.082
Echinococcus granulosus axis inhibition protein axin 0.012 0.0863 0.0949
Brugia malayi regulator of G-protein signaling egl-10 0.012 0.0863 0.082
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0136 0.014
Loa Loa (eye worm) hypothetical protein 0.0073 0.0467 0.0456
Brugia malayi Bromodomain containing protein 0.0042 0.0209 0.0163
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0123 0.0261
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0157 0.1173 0.1294
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0126
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0187 0.0196
Echinococcus granulosus beta-adrenergic receptor kinase 0.0125 0.0904 0.0994
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0442 0.0908
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1087 0.8989 1
Echinococcus granulosus pyruvate kinase 0.0576 0.4697 0.522
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0123 0.0214
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0141 0.013
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0114 0.0144
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0036
Plasmodium falciparum protein kinase 7 0.0296 0.2343 0.4938
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0141 0.0229
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0141 0.013
Mycobacterium ulcerans lipase LipD 0.0034 0.0141 0.0229
Echinococcus multilocularis pyruvate kinase 0.0576 0.4697 0.522
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0033
Loa Loa (eye worm) hypothetical protein 0.0402 0.3231 0.3224
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0126
Brugia malayi beta-lactamase family protein 0.0034 0.0141 0.0094
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0047 0.004
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0157 0.0264
Echinococcus multilocularis geminin 0.0188 0.1433 0.1583
Loa Loa (eye worm) hypothetical protein 0.0047 0.025 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0123 0.0214
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0433 0.3493 0.3485
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Loa Loa (eye worm) pyruvate kinase 0.0576 0.4697 0.4691
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0576 0.4697 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0863 0.0853
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0157 0.1173 0.1294
Echinococcus multilocularis alkaline phosphatase 0.0157 0.1173 0.1294
Echinococcus granulosus regulator of G protein signaling 3 0.012 0.0863 0.0949
Echinococcus granulosus axis inhibition protein axin 0.012 0.0863 0.0949
Echinococcus granulosus zinc finger protein 0.0022 0.0035 0.0026
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0219 0.1697 0.3589
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0047 0.004
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0047 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0904 0.0894
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0062 0.0057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0442 0.0875
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1087 0.8989 0.8988
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0157 0.0264
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0141 0.0263
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1087 0.8989 0.8985
Trypanosoma brucei glucose transporter 1E 0.0032 0.0123 0.019
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0157 0.0335
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0047 0.0036
Leishmania major glucose transporter, lmgt1 0.0032 0.0123 0.019
Echinococcus multilocularis axis inhibition protein axin 0.012 0.0863 0.0949
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Loa Loa (eye worm) hypothetical protein 0.0576 0.4697 0.4691
Schistosoma mansoni regulator of G protein signaling 0.012 0.0863 0.0853
Schistosoma mansoni z-protein (S1r protein) 0.012 0.0863 0.0853
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0141 0.0229
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0114 0.0067
Brugia malayi hypothetical protein 0.012 0.0863 0.082
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0123 0.019
Echinococcus multilocularis pyruvate kinase 0.0296 0.2339 0.2593
Schistosoma mansoni pyruvate kinase 0.0576 0.4697 0.4691
Brugia malayi Pyruvate kinase, M2 isozyme 0.0576 0.4697 0.4672
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.0725 0.0795
Entamoeba histolytica hypothetical protein 0.012 0.0863 0.2562
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0442 0.0432
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0442 0.0875
Loa Loa (eye worm) PXA domain-containing protein 0.012 0.0863 0.0853
Mycobacterium ulcerans hypothetical protein 0.0034 0.0141 0.0229
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.012 0.0863 0.0853
Loa Loa (eye worm) pyruvate kinase 0.0576 0.4697 0.4691
Schistosoma mansoni hypothetical protein 0.0188 0.1433 0.1423
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0141 0.0094
Trichomonas vaginalis pyruvate kinase, putative 0.0576 0.4697 1
Brugia malayi pyruvate kinase 0.0121 0.0873 0.083
Echinococcus multilocularis pyruvate kinase 0.0296 0.2339 0.2593
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0114 0.0115
Brugia malayi Cam kinase protein 1 0.0035 0.0144 0.0097
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0047 0.0027
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0141 0.0263
Mycobacterium leprae Probable lipase LipE 0.0034 0.0141 0.0263
Schistosoma mansoni pyruvate kinase 0.0576 0.4697 0.4691
Trypanosoma cruzi hexose transporter 0.0032 0.0123 0.0261
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0141 0.0263
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0047 0.0027
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0123 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0123 0.0214
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0114 0.0195
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0144 0.0208
Plasmodium falciparum hexose transporter 0.0104 0.0725 0.1458
Echinococcus multilocularis regulator of G protein signaling 7 0.012 0.0863 0.0949
Trypanosoma brucei pyruvate kinase 1 0.0576 0.4697 1
Echinococcus multilocularis regulator of G protein signaling 0.012 0.0863 0.0949
Schistosoma mansoni bromodomain containing protein 0.007 0.0442 0.0432
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0144 0.0097
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.1287 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0863 0.1797
Schistosoma mansoni axis inhibition protein axin 0.012 0.0863 0.0853
Echinococcus granulosus geminin 0.0188 0.1433 0.1583
Mycobacterium ulcerans beta-lactamase 0.0034 0.0141 0.0229
Toxoplasma gondii pyruvate kinase PyK1 0.0576 0.4697 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0136 0.014
Trypanosoma cruzi pyruvate kinase 2, putative 0.0576 0.4697 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0144 0.0208
Loa Loa (eye worm) hypothetical protein 0.0034 0.0141 0.013
Entamoeba histolytica hypothetical protein 0.0187 0.1428 0.4336
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0034 0.0073
Plasmodium vivax pyruvate kinase 2, putative 0.0296 0.2339 0.4929
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0062 0.0057
Echinococcus granulosus pyruvate kinase 0.0296 0.2339 0.2593
Echinococcus multilocularis GPCR, family 2 0.0034 0.0136 0.014
Brugia malayi PXA domain containing protein 0.012 0.0863 0.082
Plasmodium falciparum pyruvate kinase 0.0576 0.4697 1
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0863 0.1797
Loa Loa (eye worm) hypothetical protein 0.0433 0.3493 0.3485
Loa Loa (eye worm) hypothetical protein 0.0034 0.0141 0.013
Schistosoma mansoni protein kinase 0.0035 0.0144 0.0133
Brugia malayi A-kinase anchor protein 10, precursor 0.012 0.0863 0.082
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0047 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0442 0.0875
Schistosoma mansoni alkaline phosphatase 0.0157 0.1173 0.1163
Brugia malayi Regulator of G protein signaling domain containing protein 0.012 0.0863 0.082
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0157 0.0335
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0144 0.0208
Echinococcus multilocularis regulator of G protein signaling 3 0.012 0.0863 0.0949
Loa Loa (eye worm) hypothetical protein 0.0034 0.0141 0.013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0114 0.0103
Schistosoma mansoni hypothetical protein 0.0188 0.1433 0.1423
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Brugia malayi Bromodomain containing protein 0.0083 0.0552 0.0507
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0409 0.0443
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0157 0.0238
Loa Loa (eye worm) hypothetical protein 0.012 0.0863 0.0853
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0141 0.0252
Loa Loa (eye worm) pyruvate kinase 0.0121 0.0873 0.0863
Schistosoma mansoni hypothetical protein 0.0187 0.1428 0.1418
Echinococcus multilocularis pyruvate kinase 0.0576 0.4697 0.522
Leishmania major pyruvate kinase 0.0576 0.4697 1
Echinococcus granulosus Regulator of G protein signaling 20 0.012 0.0863 0.0949
Loa Loa (eye worm) hypothetical protein 0.0162 0.1214 0.1204
Schistosoma mansoni zinc finger protein 0.0022 0.0035 0.0024
Schistosoma mansoni axis inhibition protein axin 0.012 0.0863 0.0853
Mycobacterium tuberculosis Conserved protein 0.0034 0.0141 0.0263
Toxoplasma gondii pyruvate kinase PyKII 0.0296 0.2339 0.4943
Loa Loa (eye worm) pyruvate kinase 0.0576 0.4697 0.4691
Plasmodium vivax pyruvate kinase, putative 0.0576 0.4697 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0123 0.0214
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0136 0.009
Entamoeba histolytica hypothetical protein 0.0187 0.1428 0.4336
Entamoeba histolytica hypothetical protein 0.0187 0.1428 0.4336
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0123 0.019
Toxoplasma gondii protein kinase, putative 0.0296 0.2343 0.4952
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0141 0.0252
Schistosoma mansoni protein kinase 0.0035 0.0144 0.0133
Trichomonas vaginalis esterase, putative 0.0034 0.0141 0.0252
Schistosoma mansoni regulator of G protein signaling 0.012 0.0863 0.0853
Schistosoma mansoni glucose transport protein 0.0104 0.0725 0.0715
Loa Loa (eye worm) hypothetical protein 0.012 0.0863 0.0853
Echinococcus granulosus alkaline phosphatase 0.0157 0.1173 0.1294
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0144 0.0208
Schistosoma mansoni hypothetical protein 0.0034 0.0136 0.0126
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0141 0.0145
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0144 0.0208
Onchocerca volvulus 0.0162 0.1214 0.2355
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0433 0.3493 0.3878
Brugia malayi hypothetical protein 0.0162 0.1214 0.1172
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0141 0.0252
Echinococcus granulosus GPCR family 2 0.0034 0.0136 0.014
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0034 0.0073
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0114 0.0067
Echinococcus granulosus General substrate transporter 0.0089 0.0602 0.0659
Schistosoma mansoni regulator of G protein signaling 0.012 0.0863 0.0853
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0141 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0144 0.0258
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0103 0.0102
Leishmania major protein kinase, putative 0.0035 0.0144 0.0235
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.0725 0.0795
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0141 0.0252
Brugia malayi regulator of G-protein signaling rgs-7 0.012 0.0863 0.082
Brugia malayi Sugar transporter family protein 0.0104 0.0725 0.0681
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.1287 0.2687
Plasmodium vivax hexose transporter 0.0104 0.0725 0.1458
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0144 0.0148
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0123 0.0214
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0098 0.0674 0.1373
Schistosoma mansoni hypothetical protein 0.0082 0.0538 0.0528
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0123 0.019
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0144 0.0133
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0144 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.082 0.0809
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.012 0.0863 0.0949
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0141 0.0229
Brugia malayi hypothetical protein 0.012 0.0863 0.082
Echinococcus multilocularis regulator of G protein signaling 7 0.012 0.0863 0.0949
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0144 0.0133
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0141 0.0263
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.0725 0.0795
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0123 0.0261
Schistosoma mansoni protein kinase 0.0035 0.0144 0.0133
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.012 0.0863 0.0853
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0144 0.0235
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1087 0.8989 0.8988
Leishmania major glucose transporter, lmgt3 0.0032 0.0123 0.019
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.1287 0.2667
Leishmania major diacylglycerol acyltransferase, putative 0.0098 0.0674 0.1373
Brugia malayi MH2 domain containing protein 0.0115 0.082 0.0776
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.082 0.0809
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0017 0.0006
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0144 0.0208
Onchocerca volvulus Pyruvate kinase homolog 0.0576 0.4697 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0065 0.0054
Leishmania major pyruvate kinase 0.0576 0.4697 1
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0141 0.0263
Entamoeba histolytica hypothetical protein 0.012 0.0863 0.2562
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0144 0.0148
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0442 0.048
Trypanosoma brucei glucose transporter, putative 0.0032 0.0123 0.019
Echinococcus granulosus pyruvate kinase 0.0296 0.2339 0.2593
Echinococcus multilocularis beta adrenergic receptor kinase 0.0125 0.0904 0.0994
Echinococcus granulosus pyruvate kinase 0.0296 0.2339 0.2593
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0863 0.1797
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0114 0.0115
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0034 0.0073
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0022 0.0034 0.0023
Loa Loa (eye worm) beta-lactamase 0.0034 0.0141 0.013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0751 0.0708
Echinococcus multilocularis zinc finger protein 0.0022 0.0035 0.0026
Mycobacterium leprae Probable pyruvate kinase PykA 0.0576 0.4697 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0114 0.0103
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.0725 0.0795
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0751 0.0708
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0136 0.0126
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.012 0.0863 0.0949
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0047 0.01
Loa Loa (eye worm) hypothetical protein 0.012 0.0863 0.0853
Trypanosoma brucei glucose transporter 2A 0.0032 0.0123 0.019
Brugia malayi PXA domain containing protein 0.012 0.0863 0.082
Echinococcus multilocularis General substrate transporter 0.0089 0.0602 0.0659
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0904 0.0894
Brugia malayi beta-lactamase 0.0034 0.0141 0.0094

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 121 nM Inhibition of human MGAT2 by LC/MS assay ChEMBL. 24900580
IC50 (binding) = 121 nM MGAT LCMS Assay BINDINGDB. No reference
IC50 (binding) = 33330 nM Inhibition of human MGAT2 by SPA assay ChEMBL. 24900580
IC50 (binding) = 33330 nM MGAT SPA Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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