Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0235 | 0.028 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0267 | 0.0325 |
Plasmodium falciparum | amino acid transporter, putative | 0.0026 | 0.003 | 0.0226 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0917 | 0.2833 | 0.2812 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0048 | 0.01 | 0.0391 |
Onchocerca volvulus | 0.0036 | 0.0061 | 0.0042 | |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0048 | 0.01 | 0.007 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.0664 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.0415 | 0.0565 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.0099 | 0.0124 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0144 | 0.0197 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.0267 | 0.0364 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0061 | 0.0223 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0061 | 0.0042 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0152 | 0.0428 | 0.0545 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0226 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0144 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0428 | 0.0573 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0096 | 0.009 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 0.0684 | 0.0895 |
Brugia malayi | hypothetical protein | 0.0234 | 0.0684 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0029 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0048 | 0.01 | 0.6975 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0061 | 0.0071 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.2347 | 0.7333 | 0.7325 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0029 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0048 | 0.01 | 0.0124 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.0235 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0061 | 0.0071 |
Brugia malayi | intracellular kinase | 0.0053 | 0.0117 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0428 | 0.0573 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0917 | 0.2833 | 0.2812 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0028 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0029 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0061 | 0.0083 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0144 | 0.0156 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0061 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0061 | 0.0042 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0144 | 0.0156 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0096 | 0.009 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0096 | 0.012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0144 | 0.0156 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.0415 | 0.0554 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0096 | 0.0131 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0144 | 0.0185 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0009 | 0.0012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0144 | 0.0156 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0761 | 0.2343 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.0117 | 0.0463 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0026 | 0.003 | 0.0041 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0061 | 0.0223 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0048 | 0.01 | 0.0095 |
Echinococcus granulosus | serotonin transporter | 0.0152 | 0.0428 | 0.0545 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.2347 | 0.7333 | 1 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0053 | 0.0117 | 0.0087 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.2347 | 0.7333 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0061 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0048 | 0.01 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0415 | 0.0554 |
Echinococcus granulosus | protein kinase shaggy | 0.0053 | 0.0117 | 0.0119 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0048 | 0.01 | 0.0095 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0226 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0061 | 0.0071 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0096 | 0.009 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.0235 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0097 | 0.012 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0048 | 0.01 | 0.0095 |
Onchocerca volvulus | 0.0152 | 0.0428 | 0.0545 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0026 | 0.003 | 0.0226 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0061 | 0.0042 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0026 | 0.003 | 0.5 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0053 | 0.0117 | 0.0148 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0152 | 0.0428 | 0.0573 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0096 | 0.0066 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0028 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.1172 | 0.1589 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0028 | 0.0038 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0028 | 0.0084 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.0099 | 0.0136 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0028 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0428 | 0.0573 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0061 | 0.0223 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0061 | 0.0083 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0041 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0096 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0267 | 0.0353 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0761 | 0.2343 | 0.3195 |
Echinococcus granulosus | cyclin dependent kinase | 0.0048 | 0.01 | 0.0095 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0761 | 0.2343 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0061 | 0.0042 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0144 | 0.0156 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0009 | 0.0012 |
Plasmodium falciparum | transporter, putative | 0.0026 | 0.003 | 0.0226 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0048 | 0.01 | 0.007 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0053 | 0.0117 | 0.0148 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0028 | 0.0084 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0053 | 0.0117 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0053 | 0.0117 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0061 | 0.0083 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0048 | 0.01 | 0.0391 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0061 | 0.0083 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0096 | 0.009 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0053 | 0.0117 | 0.0463 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0061 | 0.3671 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0096 | 0.009 |
Brugia malayi | Protein kinase domain containing protein | 0.0048 | 0.01 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0029 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0061 | 0.0042 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0048 | 0.01 | 0.0391 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0053 | 0.0117 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0048 | 0.01 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0096 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.0684 | 0.0922 |
Onchocerca volvulus | 0.0036 | 0.0061 | 0.0042 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.0235 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0029 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0048 | 0.01 | 0.007 |
Brugia malayi | hypothetical protein | 0.0026 | 0.003 | 0.0041 |
Plasmodium falciparum | protein kinase 5 | 0.0048 | 0.01 | 0.8083 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0048 | 0.01 | 0.8083 |
Plasmodium vivax | amine transporter, putative | 0.0026 | 0.003 | 0.0226 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0048 | 0.01 | 0.0095 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0099 | 0.0094 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0144 | 0.0197 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0048 | 0.01 | 0.007 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0144 | 0.0115 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.003 | 0.0226 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0152 | 0.0428 | 0.0584 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0048 | 0.01 | 0.0391 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0061 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0061 | 0.0071 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0144 | 0.0156 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0061 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0917 | 0.2833 | 0.3838 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0048 | 0.01 | 0.6975 |
Loa Loa (eye worm) | serotonin transporter b | 0.0152 | 0.0428 | 0.0573 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0061 | 0.0223 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0144 | 0.0185 |
Brugia malayi | cell division control protein 2 homolog | 0.0048 | 0.01 | 0.0136 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0061 | 0.0031 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.0415 | 0.0565 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.01 | 0.697 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0099 | 0.0135 |
Entamoeba histolytica | protein kinase, putative | 0.0053 | 0.0117 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0061 | 0.0071 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0099 | 0.0094 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0235 | 0.028 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0048 | 0.01 | 0.0391 |
Echinococcus multilocularis | protein kinase shaggy | 0.0053 | 0.0117 | 0.0087 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0117 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0053 | 0.0117 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0027 | 0.0033 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0029 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.01 | 0.697 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0048 | 0.01 | 0.0095 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0152 | 0.0428 | 0.0545 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.01 | 0.697 |
Onchocerca volvulus | 0.0053 | 0.0117 | 0.0119 | |
Onchocerca volvulus | 0.0036 | 0.0061 | 0.0042 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0061 | 0.0071 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0061 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0053 | 0.0117 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0048 | 0.01 | 0.0124 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 0.0684 | 0.0656 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0053 | 0.0117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0061 | 0.0071 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0061 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0053 | 0.0117 | 0.0463 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0053 | 0.0117 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0061 | 0.0071 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.003 | 0.0226 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0226 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0048 | 0.01 | 0.0391 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.2347 | 0.7333 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0096 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.2343 | 0.3187 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0117 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0917 | 0.2833 | 0.3838 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0096 | 0.009 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0061 | 0.0083 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.2347 | 0.7333 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.2347 | 0.7333 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0053 | 0.0117 | 0.0119 |
Onchocerca volvulus | 0.0048 | 0.0099 | 0.0094 | |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0029 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0096 | 0.0131 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0026 | 0.003 | 0.0041 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0235 | 0.028 |
Plasmodium vivax | protein kinase Crk2 | 0.0048 | 0.01 | 0.8083 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.0235 | 0.028 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0761 | 0.2343 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0061 | 0.0042 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0152 | 0.0428 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0152 | 0.0428 | 0.0399 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.0235 | 0.032 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0144 | 0.0197 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0061 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0096 | 0.009 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.0235 | 0.0309 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0061 | 0.3671 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0029 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0152 | 0.0428 | 0.0573 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0048 | 0.01 | 0.0391 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0053 | 0.0117 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.