Detailed information for compound 1816357

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 350.805 | Formula: C18H15ClN6
  • H donors: 2 H acceptors: 3 LogP: 4.1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNc1nc(c2ccc(cc2)Cl)c2c(n1)n(nc2C)c1ccccc1
  • InChi: 1S/C18H15ClN6/c1-11-15-16(12-7-9-13(19)10-8-12)21-18(23-20)22-17(15)25(24-11)14-5-3-2-4-6-14/h2-10H,20H2,1H3,(H,21,22,23)
  • InChiKey: DHMQDTRSXJTDMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0505 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0106 0.0106
Loa Loa (eye worm) MBOAT family protein 0.0505 0.0831 0.0831
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0101 0.014 0.014
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0053 0.0634
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Echinococcus multilocularis transcription factor Dp 1 0.0034 0.0025 0.0025
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0505 0.0831 0.9972
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0505 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0057
Echinococcus multilocularis chromobox protein 1 0.0121 0.0173 0.0173
Loa Loa (eye worm) hhat protein 0.0505 0.0831 0.0831
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0505 0.0831 0.0831
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0016 0.0016
Echinococcus granulosus GPCR family 2 0.0042 0.0039 0.0039
Echinococcus multilocularis zinc finger protein 0.5359 0.9135 0.9135
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0011 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0021 0.0197
Trichomonas vaginalis chromobox protein, putative 0.0121 0.0173 0.1631
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0042 0.0039 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.0363 0.0363
Entamoeba histolytica vacuolar protein sorting 26 0.0505 0.0831 0.9972
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0505 0.0831 0.0831
Schistosoma mansoni sterol O-acyltransferase 1 0.0505 0.0831 0.0831
Loa Loa (eye worm) PHD-finger family protein 0.0051 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0021 0.0197
Loa Loa (eye worm) hypothetical protein 0.0424 0.0692 0.0692
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0025 0.0239
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0505 0.0831 1
Plasmodium falciparum phd finger protein, putative 0.0051 0.0053 0.0634
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0074 0.0092 0.0895
Loa Loa (eye worm) intermediate filament protein 0.0026 0.001 0.001
Echinococcus granulosus L aminoadipate semialdehyde 0.0069 0.0085 0.0085
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0505 0.0831 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0505 0.0831 0.9631
Echinococcus granulosus zinc finger protein 0.5359 0.9135 0.9135
Loa Loa (eye worm) MBOAT family protein 0.0505 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0505 0.0831 0.0831
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0048 0.0455
Toxoplasma gondii hypothetical protein 0.0505 0.0831 1
Schistosoma mansoni hypothetical protein 0.0086 0.0114 0.0114
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0505 0.0831 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.001
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.5864 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0507 0.0833 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0505 0.0831 0.0831
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0505 0.0831 0.0831
Loa Loa (eye worm) MBOAT family protein 0.5864 1 1
Leishmania major hypothetical protein, conserved 0.0035 0.0025 0.0105
Schistosoma mansoni hypothetical protein 0.0766 0.1277 0.1277
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0025 0.0025
Schistosoma mansoni zinc finger protein 0.5864 1 1
Echinococcus granulosus intermediate filament protein 0.0026 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0025 0.0105
Echinococcus multilocularis cpg binding protein 0.0057 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0042 0.0039 0.0039
Echinococcus granulosus dnaJ subfamily B 0.0766 0.1277 0.1277
Echinococcus multilocularis survival motor neuron protein 1 0.0424 0.0692 0.0692
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0025 0.0025
Echinococcus multilocularis Chromobox protein 3 0.002 0.0000000057622 0.0000000057622
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0121 0.0173 0.1631
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0524 0.0862 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0082 0.0106 0.1273
Echinococcus granulosus lamin dm0 0.0026 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0068 0.0082 0.0082
Brugia malayi beta-lactamase family protein 0.0035 0.0025 0.0025
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0059 0.0068 0.0608
Brugia malayi Latrophilin receptor protein 2 0.0042 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0042 0.0039 0.0039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0021 0.0197
Onchocerca volvulus 0.0035 0.0025 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0016 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0016 0.0016
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0016 0.0016
Echinococcus granulosus PHD finger protein rhinoceros 0.0051 0.0053 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0106 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0248 0.039 0.442
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0215 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0092 0.0123 0.0123
Onchocerca volvulus 0.0505 0.0831 0.784
Leishmania major glycerol uptake protein, putative 0.0505 0.0831 0.9631
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0025 0.0025
Treponema pallidum fructose-bisphosphate aldolase 0.0507 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0016 0.0016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0082 0.0106 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0042 0.0039 0.0039
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0059 0.0068 0.0068
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0248 0.039 0.442
Echinococcus granulosus phd:f box containing protein 0.0029 0.0016 0.0016
Echinococcus granulosus neuropeptide s receptor 0.0416 0.0679 0.0679
Echinococcus granulosus Chromobox protein 3 0.002 0.0000000057622 0.0000000057622
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0117 0.0166 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0104 0.0145 0.0145
Leishmania major glycerol uptake protein, putative 0.0505 0.0831 0.9631
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Entamoeba histolytica hypothetical protein, conserved 0.0505 0.0831 0.9972
Brugia malayi CXXC zinc finger family protein 0.0054 0.0058 0.0058
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0505 0.0831 0.0831
Leishmania major glycerol uptake protein, putative 0.0505 0.0831 0.9631
Schistosoma mansoni hypothetical protein 0.0042 0.0039 0.0039
Leishmania major glycerol uptake protein, putative 0.0505 0.0831 0.9631
Schistosoma mansoni cpg binding protein 0.0057 0.0063 0.0063
Brugia malayi CHD4 protein 0.0023 0.0005 0.0005
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0215 0.0333 0.0333
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0028 0.0028
Trypanosoma cruzi glycerol uptake protein, putative 0.0505 0.0831 0.9631
Echinococcus multilocularis sterol O acyltransferase 1 0.0505 0.0831 0.0831
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0505 0.0831 0.0831
Plasmodium vivax JmjC domain containing protein 0.0029 0.0016 0.0198
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.001 0.001
Echinococcus granulosus cpg binding protein 0.0057 0.0063 0.0063
Brugia malayi jmjC domain containing protein 0.0113 0.016 0.016
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0016 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0042 0.0039 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0025 0.0239
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0073 0.0091 0.0857
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0505 0.0831 0.0831
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0016 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0113 0.016 0.016
Trypanosoma cruzi GUP1, putative 0.0505 0.0831 0.9631
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0505 0.0831 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0134 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0505 0.0831 0.0831
Echinococcus multilocularis L aminoadipate semialdehyde 0.0069 0.0085 0.0085
Brugia malayi Heterochromatin protein 1 0.0121 0.0173 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0025 0.0239
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.016 0.016
Echinococcus granulosus lamin 0.0026 0.001 0.001
Echinococcus granulosus chromobox protein 1 0.0121 0.0173 0.0173
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0524 0.0862 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0082 0.0774
Loa Loa (eye worm) CXXC zinc finger family protein 0.0054 0.0058 0.0058
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2297 0.3896 0.3896
Leishmania major mitochondrial DNA polymerase beta 0.0524 0.0862 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0059 0.0068 0.0068
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0091 0.0857
Echinococcus granulosus o acyltransferase membrane bound domain 0.0505 0.0831 0.0831
Onchocerca volvulus Alhambra homolog 0.0051 0.0053 0.0497
Echinococcus multilocularis PHD finger protein rhinoceros 0.0051 0.0053 0.0053
Loa Loa (eye worm) heterochromatin protein 1 0.0121 0.0173 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0025 0.0304
Echinococcus multilocularis neuropeptide s receptor 0.0416 0.0679 0.0679
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0042 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0505 0.0831 0.0831
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0016 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0042 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0505 0.0831 0.9972
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0505 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0505 0.0831 0.0831
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0005 0.0005
Onchocerca volvulus 0.0035 0.0025 0.0239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0021 0.0197
Trypanosoma cruzi GUP1, putative 0.0505 0.0831 0.9631
Echinococcus multilocularis lysine specific demethylase 5A 0.011 0.0155 0.0155
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0005 0.0005
Brugia malayi diacylglycerol acyltransferase 0.0505 0.0831 0.0831
Brugia malayi hypothetical protein 0.0424 0.0692 0.0692
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0016 0.0198
Echinococcus granulosus transcription factor Dp 1 0.0034 0.0025 0.0025
Brugia malayi PHD-finger family protein 0.0051 0.0053 0.0053
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0505 0.0831 0.0831
Echinococcus granulosus o acyltransferase membrane bound domain 0.0505 0.0831 0.0831
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Brugia malayi latrophilin 2 splice variant baaae 0.0092 0.0123 0.0123
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.5864 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0025 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0051 0.0053 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0025 0.0025
Echinococcus granulosus chromobox protein 1 0.0121 0.0173 0.0173
Brugia malayi jmjC domain containing protein 0.0215 0.0333 0.0333
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0021 0.0197
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0022 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0091 0.0857
Schistosoma mansoni hypothetical protein 0.0092 0.0123 0.0123
Trichomonas vaginalis porcupine, putative 0.0505 0.0831 0.784
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Onchocerca volvulus 0.0054 0.0058 0.0549
Brugia malayi MH2 domain containing protein 0.0232 0.0363 0.0363
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.009 0.012 0.1221
Leishmania major hypothetical protein, conserved 0.0505 0.0831 0.9631
Echinococcus multilocularis GPCR, family 2 0.0042 0.0039 0.0039
Echinococcus granulosus sterol O acyltransferase 1 0.0505 0.0831 0.0831
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0042 0.0039 0.0039
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0059 0.0068 0.0608
Echinococcus granulosus peregrin 0.0051 0.0053 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0134 0.0196 0.0196
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.0363 0.0363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0021 0.0197
Brugia malayi Bromodomain containing protein 0.0051 0.0053 0.0053
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0248 0.039 1
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0505 0.0831 0.0831
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0248 0.039 0.442
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0016 0.0016
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0505 0.0831 0.0831
Echinococcus multilocularis lamin 0.0026 0.001 0.001
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0016 0.0016
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0505 0.0831 0.0831
Brugia malayi chromobox protein homolog 3 0.0068 0.0082 0.0082
Echinococcus granulosus survival motor neuron protein 1 0.0424 0.0692 0.0692
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0505 0.0831 0.0831
Onchocerca volvulus 0.0069 0.0085 0.0799
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0106 0.0106
Trypanosoma cruzi glycerol uptake protein, putative 0.0505 0.0831 0.9631
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0505 0.0831 0.0831
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0005 0.0005
Toxoplasma gondii ABC1 family protein 0.0035 0.0025 0.0304
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0505 0.0831 0.0831
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0021 0.0197
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Plasmodium vivax SET domain protein, putative 0.0082 0.0106 0.1273
Schistosoma mansoni cpg binding protein 0.0054 0.0058 0.0058
Onchocerca volvulus 0.0101 0.014 0.1317
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0248 0.039 0.8828
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0248 0.039 0.8828
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0051 0.0053 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0025 0.0105
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0000051572 0.0001
Trichomonas vaginalis esterase, putative 0.0035 0.0025 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0068 0.0082 0.0774
Echinococcus multilocularis lamin dm0 0.0026 0.001 0.001
Toxoplasma gondii PHD-finger domain-containing protein 0.0051 0.0053 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0505 0.0831 0.784
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0086 0.0114 0.0114
Onchocerca volvulus 0.0086 0.0114 0.1077
Brugia malayi SET domain containing protein 0.0024 0.0007 0.0007
Brugia malayi MBOAT family protein 0.0505 0.0831 0.0831
Loa Loa (eye worm) beta-lactamase 0.0035 0.0025 0.0025
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0059 0.0068 0.0068
Onchocerca volvulus 0.0053 0.0057 0.0538
Echinococcus multilocularis jumonji domain containing protein 0.007 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0011 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0507 0.0833 0.7862
Trichomonas vaginalis conserved hypothetical protein 0.0505 0.0831 0.784
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0134 0.0196 0.0196
Schistosoma mansoni lamin 0.0026 0.001 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0766 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0039
Echinococcus multilocularis chromobox protein 1 0.0121 0.0173 0.0173
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0059 0.0068 0.0608
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0524 0.0862 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0069 0.0085 0.0085
Mycobacterium tuberculosis Conserved hypothetical protein 0.0276 0.0438 1
Schistosoma mansoni hypothetical protein 0.0042 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.01 0.0137 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0134 0.0196 0.0196
Onchocerca volvulus 0.0639 0.106 1
Onchocerca volvulus 0.0035 0.0025 0.0239
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0221 0.0344 0.7718
Loa Loa (eye worm) hhat protein 0.0505 0.0831 0.0831
Schistosoma mansoni hypothetical protein 0.0315 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0082 0.0106 0.0106
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Echinococcus granulosus lysine specific demethylase 5A 0.0113 0.016 0.016
Brugia malayi intermediate filament protein 0.0026 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Echinococcus multilocularis geminin 0.0315 0.0506 0.0506
Plasmodium vivax hypothetical protein, conserved 0.002 0.0000051572 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0181 0.0275 0.0275
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0562 0.0927 0.0927
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0074 0.0092 0.0895
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0016 0.0198
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0069 0.0085 0.0085
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0505 0.0831 0.0831
Brugia malayi Pre-SET motif family protein 0.0082 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0315 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0505 0.0831 0.0831
Brugia malayi MBOAT family protein 0.0505 0.0831 0.0831
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0016 0.0016
Brugia malayi Pre-SET motif family protein 0.0562 0.0927 0.0927
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0016 0.0016
Brugia malayi Hhat protein 0.0505 0.0831 0.0831
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0507 0.0833 1
Trichomonas vaginalis set domain proteins, putative 0.0639 0.106 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0074 0.0092 0.0895
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0059 0.0068 0.0068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0025 0.0025
Onchocerca volvulus 0.0026 0.001 0.0099
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.001 0.001
Trichomonas vaginalis transmembrane protein nessy, putative 0.0505 0.0831 0.784
Loa Loa (eye worm) hypothetical protein 0.0069 0.0085 0.0085
Echinococcus granulosus geminin 0.0315 0.0506 0.0506
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0016 0.0198
Brugia malayi beta-lactamase 0.0035 0.0025 0.0025
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0505 0.0831 0.9972
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0021 0.0197
Echinococcus granulosus jumonji domain containing protein 0.007 0.0087 0.0087
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0074 0.0092 0.0895
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0059 0.0068 0.0608
Schistosoma mansoni lamin 0.0026 0.001 0.001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0077 0.0099 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0025 0.0105
Onchocerca volvulus 0.0026 0.001 0.0099
Schistosoma mansoni survival motor neuron protein 0.0086 0.0114 0.0114
Schistosoma mansoni chromobox protein 0.0121 0.0173 0.0173
Brugia malayi MBOAT family protein 0.0505 0.0831 0.0831
Brugia malayi beta-lactamase family protein 0.0035 0.0025 0.0025
Echinococcus granulosus neuropeptide receptor A26 0.0416 0.0679 0.0679
Echinococcus multilocularis peregrin 0.0051 0.0053 0.0053
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0505 0.0831 0.9972
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Echinococcus granulosus o acyltransferase membrane bound domain 0.0505 0.0831 0.0831
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0082 0.0106 0.0106
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0025 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0505 0.0831 0.784
Mycobacterium ulcerans hypothetical protein 0.0276 0.0438 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0082 0.0106 0.0106
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0059 0.0068 0.0815
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0016 0.0016
Giardia lamblia Fructose-bisphosphate aldolase 0.0507 0.0833 1
Echinococcus multilocularis neuropeptide receptor A26 0.0416 0.0679 0.0679
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0091
Brugia malayi MBOAT family protein 0.0505 0.0831 0.0831
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0048 0.0455
Trypanosoma brucei glycerol uptake protein, putative 0.0505 0.0831 0.9631
Echinococcus multilocularis musashi 0.0026 0.001 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.016 0.016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0105 0.0146 0.1753
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0051 0.0053 0.0053
Leishmania major glycerol uptake protein, putative 0.0505 0.0831 0.9631
Toxoplasma gondii PHD-finger domain-containing protein 0.0051 0.0053 0.0634
Schistosoma mansoni cpg binding protein 0.0057 0.0063 0.0063
Trypanosoma brucei glycerol uptake protein, putative 0.0505 0.0831 0.9631
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0059 0.0068 0.0068
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0505 0.0831 0.0831
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0082 0.0774
Schistosoma mansoni chromobox protein 0.0121 0.0173 0.0173
Toxoplasma gondii hypothetical protein 0.0084 0.0111 0.1332
Onchocerca volvulus 0.002 0.0000000057622 0.000000054371

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 10 mm Antibacterial activity against Escherichia coli O157:H7 isolated from poultry at 100 ug/ml after 24 hr by agar well diffusion method ChEMBL. No reference
IZ (functional) = 16 mm Antifungal activity against Candida albicans at 100 ug/ml after 48 to 72 hr by agar well diffusion method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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