TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 342.425 | Formula: C21H24F2N2
H donors: 1 H acceptors: 0 LogP: 4.4 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1[C@@H]2CC[C@H]1C[C@@H](C2)NC(c1ccc(cc1)F)c1ccc(cc1)F
InChi: 1S/C21H24F2N2/c1-25-19-10-11-20(25)13-18(12-19)24-21(14-2-6-16(22)7-3-14)15-4-8-17(23)9-5-15/h2-9,18-21,24H,10-13H2,1H3/t18-,19-,20+
InChiKey: QVIXLSYROOSFHA-OWZKRDHZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	636 aa	31.8 %
Neospora caninum	sodium-dependent transporter, putative	Dopamine transporter	619 aa	498 aa	32.3 %
Echinococcus granulosus	sodium and chloride dependent glycine	Dopamine transporter	619 aa	594 aa	41.4 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Dopamine transporter	619 aa	509 aa	40.1 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Dopamine transporter	619 aa	551 aa	39.9 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Dopamine transporter	619 aa	578 aa	32.9 %
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Dopamine transporter	619 aa	604 aa	37.9 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Dopamine transporter	619 aa	599 aa	41.9 %
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	558 aa	41.8 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Dopamine transporter	619 aa	557 aa	23.9 %
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	588 aa	40.3 %
Onchocerca volvulus		Dopamine transporter	619 aa	612 aa	23.5 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Dopamine transporter	619 aa	599 aa	44.2 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Dopamine transporter	619 aa	522 aa	36.0 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	32.9 %
Plasmodium vivax	hypothetical protein, conserved	Dopamine transporter	619 aa	657 aa	20.1 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	33.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0227	0.1683	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0103	0.0402	0.0402
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0107	0.044	0.044
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0107	0.044	0.044
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0227	0.1683	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0103	0.0402	0.0402
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Brugia malayi	integrin-linked kinase	0.0077	0.0136	0.0806
Schistosoma mansoni	tyrosine kinase	0.0107	0.044	0.044
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0077	0.0136	0.0136
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0107	0.044	0.044
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0103	0.0402	0.0402
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0227	0.1683	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0643	0.3227
Loa Loa (eye worm)	FKBP5 protein	0.0227	0.1683	0.8448
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0078	0.0143	0.0143
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0107	0.044	0.044
Schistosoma mansoni	ephrin receptor	0.0077	0.0136	0.0136
Onchocerca volvulus		0.0077	0.0136	0.1857
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0077	0.0136	0.0136
Brugia malayi	SH2 domain containing protein	0.0103	0.0402	0.2387
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0126	0.0643	0.3819
Brugia malayi	hypothetical protein	0.0077	0.0136	0.0806
Echinococcus granulosus	tyrosine kinase	0.0103	0.0402	0.0402
Echinococcus granulosus	integrin linked protein kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	protein tyrosine kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0107	0.044	0.044
Brugia malayi	Integrin alpha pat-2 precursor	0.0167	0.1061	0.6307
Schistosoma mansoni	tyrosine kinase	0.0107	0.044	0.044
Brugia malayi	Guanylyl cyclase protein 23	0.0077	0.0136	0.0806
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.0136	0.0681
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.0136	0.0136
Brugia malayi	hypothetical protein	0.0077	0.0136	0.0806
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0078	0.0143	0.0143
Loa Loa (eye worm)	TK/Met protein kinase	0.0077	0.0136	0.0681
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0077	0.0136	0.1857
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0077	0.0136	0.0806
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Echinococcus multilocularis	epidermal growth factor receptor	0.0077	0.0136	0.0136
Echinococcus granulosus	raf serine:threonine protein kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Onchocerca volvulus		0.0103	0.0402	0.5498
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/RYK protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0107	0.044	0.044
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.0136	0.0681
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Loa Loa (eye worm)	TK/ABL protein kinase	0.0103	0.0402	0.2016
Echinococcus granulosus	receptor type guanylyl cyclase	0.0077	0.0136	0.0136
Brugia malayi	Tyrosine-protein kinase PR2	0.0077	0.0136	0.0806
Brugia malayi	Protein kinase domain containing protein	0.0103	0.0402	0.2387
Echinococcus multilocularis	integrin linked protein kinase	0.0077	0.0136	0.0136
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0746	0.7015	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0107	0.044	0.044
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Loa Loa (eye worm)	TK/FAK protein kinase	0.0077	0.0136	0.0681
Brugia malayi	ephrin receptor 1 precursor	0.0077	0.0136	0.0806
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Brugia malayi	hypothetical protein	0.0103	0.0402	0.2387
Echinococcus granulosus	protein kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	immunophilin	0.0227	0.1683	0.1683
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0227	0.1683	0.1683
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus granulosus	natriuretic peptide receptor 1	0.0077	0.0136	0.0136
Echinococcus multilocularis	transfer RNA-Thr	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	TK/CSK protein kinase	0.0109	0.0464	0.2332
Leishmania major	protein kinase, putative	0.0078	0.0143	0.0045
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0107	0.044	0.044
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0469	0.2355
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0007	0.0042
Schistosoma mansoni	tyrosine protein kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.0136	0.0681
Trypanosoma brucei	protein kinase, putative	0.0078	0.0143	0.0045
Schistosoma mansoni	ephrin receptor	0.0077	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Leishmania major	peptidylprolyl isomerase-like protein	0.0227	0.1683	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0107	0.044	0.044
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0077	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Plasmodium falciparum	protein kinase, putative	0.0078	0.0143	0.0045
Echinococcus granulosus	activated cdc42 kinase 1	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0746	0.7015	0.5
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0077	0.0136	0.0136
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0077	0.0136	0.0136
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0942	0.9033	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0103	0.0402	0.0402
Echinococcus granulosus	tyrosine kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0103	0.0402	0.0402
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0227	0.1683	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0109	0.0469	0.2787
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0077	0.0136	0.0136
Onchocerca volvulus		0.0103	0.0402	0.5498
Entamoeba histolytica	protein kinase domain containing protein	0.0078	0.0143	0.0045
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.0136	0.0136
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0227	0.1683	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0109	0.0464	0.0464
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0077	0.0136	0.0136
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0227	0.1683	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Brugia malayi	C-terminal src kinase protein 1	0.0077	0.0136	0.0806
Brugia malayi	Protein kinase domain containing protein	0.0103	0.0402	0.2387
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0077	0.0136	0.0136
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0227	0.1683	1
Onchocerca volvulus		0.0077	0.0136	0.1857
Brugia malayi	Protein kinase domain containing protein	0.0103	0.0402	0.2387
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	insulin receptor	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0469	0.2355
Echinococcus multilocularis	fk506 binding protein	0.0227	0.1683	0.1683
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0107	0.044	0.044
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0196	0.1361	0.6831
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0077	0.0136	0.0806
Onchocerca volvulus		0.0077	0.0136	0.1857
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0078	0.0143	0.001
Loa Loa (eye worm)	TK/DDR protein kinase	0.0077	0.0136	0.0681
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus granulosus	integrin alpha ps	0.0075	0.0113	0.0113
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	protein tyrosine kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0227	0.1683	0.1683
Echinococcus multilocularis	activin receptor type	0.0078	0.0143	0.0143
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0107	0.044	0.044
Echinococcus multilocularis	tyrosine protein kinase csk	0.0109	0.0464	0.0464
Brugia malayi	Protein kinase domain containing protein	0.0103	0.0402	0.2387
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0078	0.0143	0.0045
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0109	0.0469	0.2355
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0227	0.1683	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/ALK protein kinase	0.0077	0.0136	0.0681
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0227	0.1683	0.1683
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0077	0.0136	0.0806
Schistosoma mansoni	tyrosine kinase	0.0139	0.0769	0.0769
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0077	0.0136	0.0806
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0174	0.0174
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0227	0.1683	1
Echinococcus granulosus	integrin alpha 3	0.0128	0.066	0.066
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	protein kinase	0.0078	0.0143	0.0143
Onchocerca volvulus		0.0109	0.0469	0.6422
Schistosoma mansoni	hypothetical protein	0.0077	0.0136	0.0136
Echinococcus granulosus	activin receptor type	0.0078	0.0143	0.0143
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0107	0.044	0.044
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	protein tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0077	0.0136	0.0136
Echinococcus granulosus	serotonin transporter	0.0109	0.0469	0.0469
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0077	0.0136	0.0136
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0077	0.0136	0.0681
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0077	0.0136	0.0136
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0078	0.0143	0.0045
Echinococcus multilocularis	tyrosine protein kinase	0.0077	0.0136	0.0136
Brugia malayi	Furin-like cysteine rich region family protein	0.0077	0.0136	0.0806
Echinococcus multilocularis	integrin alpha 3	0.0128	0.066	0.066
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase shark	0.1036	1	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0109	0.0469	0.0469
Echinococcus multilocularis	protein kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0077	0.0136	0.0136
Schistosoma mansoni	serine/threonine RGC	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase csk	0.0109	0.0464	0.0464
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Onchocerca volvulus		0.0077	0.0136	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0136	0.0681
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0077	0.0136	0.0136
Echinococcus multilocularis	heat shock protein 70	0.0077	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Loa Loa (eye worm)	TK/ROR protein kinase	0.0077	0.0136	0.0681
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0227	0.1683	1
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Onchocerca volvulus		0.0077	0.0136	0.1857
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0107	0.044	0.044
Loa Loa (eye worm)	integrin alpha pat-2	0.0258	0.1992	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0077	0.0136	0.0136
Echinococcus granulosus	epidermal growth factor receptor	0.0077	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus granulosus	c src tyrosine kinase	0.0139	0.0769	0.0769
Onchocerca volvulus		0.0103	0.0402	0.5498
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Schistosoma mansoni	immunophilin	0.0227	0.1683	0.1683
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0103	0.0402	0.0402
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase csk	0.0109	0.0464	0.0464
Echinococcus granulosus	tyrosine protein kinase csk	0.0109	0.0464	0.0464
Echinococcus multilocularis	protein kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase Srms	0.0103	0.0402	0.0402
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0227	0.1683	1
Onchocerca volvulus		0.0103	0.0402	0.5498
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0077	0.0136	0.0806
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0077	0.0136	0.0681
Echinococcus multilocularis	tyrosine protein kinase csk	0.0109	0.0464	0.0464
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0103	0.0402	0.1719
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0402	0.2016
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0107	0.0447	0.0447
Brugia malayi	Raf kinase	0.0077	0.0136	0.0806
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	epidermal growth factor receptor	0.0077	0.0136	0.0136
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0077	0.0136	0.0136
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0107	0.044	0.044
Loa Loa (eye worm)	norepinephrine transporter	0.0109	0.0469	0.2355
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0077	0.0136	0.0806
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	activated cdc42 kinase 1	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.101	0.9734	0.9734
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0227	0.1683	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0077	0.0136	0.0681
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus multilocularis	integrin alpha ps	0.0075	0.0113	0.0113
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0227	0.1683	1
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Echinococcus granulosus	ephrin type A receptor 4 A	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0692	0.3474
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0227	0.1683	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0227	0.1683	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0077	0.0136	0.0136
Echinococcus multilocularis	c src tyrosine kinase	0.0139	0.0769	0.0769
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0077	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0469	0.2355
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0077	0.0136	0.0136
Onchocerca volvulus		0.0103	0.0402	0.5498
Loa Loa (eye worm)	SRC-1	0.0107	0.044	0.2208
Schistosoma mansoni	protein kinase	0.0078	0.0143	0.0143
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0107	0.044	0.044
Brugia malayi	Protein kinase domain containing protein	0.0103	0.0402	0.2387
Schistosoma mansoni	sodium/chloride dependent transporter	0.0109	0.0469	0.0469
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0077	0.0136	0.0136
Brugia malayi	SRC-1	0.0107	0.044	0.2613
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	integrin alpha-ps	0.0075	0.0113	0.0113
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Brugia malayi	SH2 domain containing protein	0.0135	0.073	0.4341
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0077	0.0136	0.0136
Onchocerca volvulus		0.0135	0.073	1
Schistosoma mansoni	tyrosine kinase	0.1036	1	1
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0107	0.044	0.044
Loa Loa (eye worm)	TK protein kinase	0.0103	0.0402	0.2016
Loa Loa (eye worm)	TK/INSR protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0103	0.0402	0.0402
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0077	0.0136	0.0136
Schistosoma mansoni	protein kinase	0.0078	0.0143	0.0143
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0077	0.0136	0.0681
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0077	0.0136	0.1857
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0103	0.0402	0.0402
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0077	0.0136	0.0136
Brugia malayi	Receptor family ligand binding region containing protein	0.0077	0.0136	0.0806
Echinococcus multilocularis	epidermal growth factor receptor	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase Blk	0.0103	0.0402	0.0402
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Brugia malayi	protein-tyrosine kinase	0.0103	0.0402	0.2387
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0227	0.1683	0.1683
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Schistosoma mansoni	tyrosine kinase	0.0103	0.0402	0.0402
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0077	0.0136	0.0136
Echinococcus multilocularis	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0077	0.0136	0.0806
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0077	0.0136	0.0136
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0077	0.0136	0.0806
Leishmania major	fk506-binding protein 1-like protein	0.0227	0.1683	1
Echinococcus multilocularis	tyrosine kinase	0.0103	0.0402	0.0402
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0227	0.1683	1
Schistosoma mansoni	integrin alpha	0.0167	0.1061	0.1061
Schistosoma mansoni	tyrosine kinase	0.0107	0.044	0.044
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0077	0.0136	0.0681
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.0136	0.0681
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Onchocerca volvulus		0.0077	0.0136	0.1857
Echinococcus multilocularis	insulin receptor	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.0136	0.0681
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0077	0.0136	0.0136
Echinococcus multilocularis	FL cytokine receptor	0.0077	0.0136	0.0136
Echinococcus granulosus	activated cdc42 kinase 1	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0078	0.0143	0.0045
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0107	0.044	0.044
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0077	0.0136	0.0136
Echinococcus multilocularis	serotonin transporter	0.0109	0.0469	0.0469
Trichomonas vaginalis	fk506-binding protein, putative	0.0227	0.1683	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.0136	0.0681
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0077	0.0136	0.0136
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0077	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase csk	0.0109	0.0464	0.0464
Schistosoma mansoni	immunophilin	0.0196	0.1361	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0291	0.146
Loa Loa (eye worm)	serotonin transporter b	0.0109	0.0469	0.2355
Loa Loa (eye worm)	TK protein kinase	0.0077	0.0136	0.0681
Echinococcus multilocularis	integrin alpha ps	0.0075	0.0113	0.0113
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0107	0.044	0.044
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0077	0.0136	0.0681
Brugia malayi	Tyrosine-protein kinase abl-1	0.0107	0.044	0.2613
Onchocerca volvulus		0.0077	0.0136	0.1857
Onchocerca volvulus	Tyrosine kinase homolog	0.0077	0.0136	0.1857
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0107	0.044	0.044
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0107	0.044	0.044
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0227	0.1683	0.8448
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0227	0.1683	0.5
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0196	0.1361	0.1361
Trichomonas vaginalis	immunophilin, putative	0.0227	0.1683	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Schistosoma mansoni	protein kinase	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0077	0.0136	0.0136
Echinococcus granulosus	kinase suppressor of Ras 1	0.0077	0.0136	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0103	0.0402	0.2016
Echinococcus granulosus	tyrosine protein kinase HCK	0.0077	0.0136	0.0136
Echinococcus granulosus	tyrosine kinase	0.0103	0.0402	0.0402
Loa Loa (eye worm)	TK/ACK protein kinase	0.0077	0.0136	0.0681
Onchocerca volvulus		0.0077	0.0136	0.1857
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0196	0.1361	0.1361
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0077	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0077	0.0136	0.0806
Loa Loa (eye worm)	serine/threonine protein kinase	0.0077	0.0136	0.0681
Echinococcus granulosus	tyrosine protein kinase	0.0077	0.0136	0.0136
Onchocerca volvulus		0.0077	0.0136	0.1857
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0077	0.0136	0.0806

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 59.4 nM	Displacement of [3H]Pirenzepine from Muscarinic receptor M1	ChEMBL.	16213721
Ki (binding)	= 661 nM	Displacement of [3H]WIN from DAT in rat brain membrane	ChEMBL.	16213721
Ki (binding)	= 48500 nM	Displacement of [3H]Citalopram from SERT	ChEMBL.	16213721
Ki (binding)	= 152000 nM	Displacement of [3H]Nisoxetine from NET	ChEMBL.	16213721

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3085019

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1821925