TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 394.53 | Formula: C23H26N2O2S
H donors: 0 H acceptors: 3 LogP: 5.3 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CSCc1ccc(nc1)c1cnc(o1)C(=O)CCCCCCc1ccccc1
InChi: 1S/C23H26N2O2S/c1-28-17-19-13-14-20(24-15-19)22-16-25-23(27-22)21(26)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16H,2-3,5,8-9,12,17H2,1H3
InChiKey: CGQZFHYRTLCHSU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Echinococcus granulosus	nephrin	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0109	0	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.037	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.037	0.706	0.706
Echinococcus multilocularis	anosmin 1	0.037	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.037	0.706	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0109	0	0.5
Brugia malayi	hypothetical protein	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.037	0.706	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	0.0386	0.0386
Schistosoma mansoni	nephrin	0.037	0.706	0.706
Onchocerca volvulus		0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus granulosus	contactin	0.037	0.706	0.706
Onchocerca volvulus		0.037	0.706	1
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.037	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Schistosoma mansoni	nephrin	0.037	0.706	0.706
Echinococcus multilocularis	roundabout 2	0.037	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.037	0.706	0.706
Brugia malayi	hypothetical protein	0.037	0.706	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.037	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.037	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.037	0.706	0.706
Onchocerca volvulus		0.037	0.706	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.037	0.706	0.706
Trichomonas vaginalis	protein kinase atn1, putative	0.0109	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.037	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.037	0.706	0.706
Echinococcus granulosus	Fibronectin type III domain containing protein	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0109	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.037	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Loa Loa (eye worm)	projectin	0.037	0.706	1
Schistosoma mansoni	tripartite motif protein trim9	0.037	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.037	0.706	1
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.037	0.706	0.706
Echinococcus multilocularis	Netrin receptor DCC	0.037	0.706	0.706
Plasmodium vivax	protein kinase, putative	0.0109	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0109	0	0.5
Echinococcus granulosus	Fibronectin type III	0.037	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.037	0.706	0.706
Schistosoma mansoni	serine/threonine protein kinase	0.037	0.706	0.706
Loa Loa (eye worm)	myotactin form A	0.037	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus multilocularis	cell adhesion molecule	0.037	0.706	0.706
Schistosoma mansoni	hemicentin	0.037	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Leishmania major	hypothetical protein, conserved	0.037	0.706	1
Giardia lamblia	Kinase, NEK	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0109	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	ankyrin repeat protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.037	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Echinococcus granulosus	titin	0.037	0.706	0.706
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	0.0386	0.0386
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Schistosoma mansoni	myosin-binding protein-related	0.037	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.037	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.037	0.706	0.706
Echinococcus granulosus	neuroglian	0.037	0.706	0.706
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.037	0.706	1
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Loa Loa (eye worm)	lethal protein 805	0.037	0.706	1
Onchocerca volvulus		0.037	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus granulosus	roundabout 2	0.037	0.706	0.706
Onchocerca volvulus		0.037	0.706	1
Echinococcus multilocularis	titin	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase	0.037	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Plasmodium falciparum	protein kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.037	0.706	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.037	0.706	0.706
Schistosoma mansoni	factor for adipocyte differentiation	0.037	0.706	0.706
Echinococcus granulosus	anosmin 1	0.037	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.037	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Giardia lamblia	Kinase	0.0109	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.037	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Brugia malayi	myotactin form A	0.037	0.706	1
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.037	0.706	0.706
Schistosoma mansoni	neuroglian	0.037	0.706	0.706
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.037	0.706	0.706
Entamoeba histolytica	receptor protein kinase, putative	0.0109	0	0.5
Schistosoma mansoni	hypothetical protein	0.037	0.706	0.706
Schistosoma mansoni	factor for adipocyte differentiation	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.037	0.706	1
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0	0.5
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0109	0	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.037	0.706	0.706
Echinococcus granulosus	Netrin receptor DCC	0.037	0.706	0.706
Echinococcus multilocularis	Netrin receptor DCC	0.037	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.037	0.706	0.706
Echinococcus granulosus	titin	0.037	0.706	0.706
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0109	0	0.5
Echinococcus granulosus	cell adhesion molecule	0.037	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Giardia lamblia	Protein 21.1	0.0109	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0109	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Trypanosoma cruzi	hypothetical protein, conserved	0.037	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0109	0	0.5
Schistosoma mansoni	hypothetical protein	0.037	0.706	0.706
Echinococcus granulosus	anosmin 1	0.037	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.037	0.706	1
Schistosoma mansoni	titin	0.037	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0109	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Echinococcus granulosus	Netrin receptor DCC	0.037	0.706	0.706
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0479	1	1
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus granulosus	usherin	0.037	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Brugia malayi	Lethal protein 805	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Toxoplasma gondii	STE kinase	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Echinococcus granulosus	G1Y162 protein	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.037	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.037	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0386	0.0547
Brugia malayi	Fibronectin type III domain containing protein	0.037	0.706	1
Echinococcus multilocularis	roundabout 2	0.037	0.706	0.706
Echinococcus multilocularis	neuroglian	0.037	0.706	0.706
Echinococcus multilocularis	transfer RNA-Phe	0.037	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Loa Loa (eye worm)	CAMK protein kinase	0.037	0.706	1
Brugia malayi	amidase	0.0123	0.0386	0.0547
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Echinococcus granulosus	fibronectin type III domain-containing protein	0.037	0.706	0.706
Echinococcus granulosus	EG95	0.037	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Echinococcus multilocularis	titin	0.037	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0109	0	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.037	0.706	0.706
Loa Loa (eye worm)	UNCoordinated family member	0.037	0.706	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	0.0386	0.0386
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Schistosoma mansoni	titin	0.037	0.706	0.706
Schistosoma mansoni	fatty-acid amide hydrolase	0.0123	0.0386	0.0386
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Brugia malayi	myotactin form B	0.037	0.706	1
Schistosoma mansoni	hypothetical protein	0.037	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Plasmodium falciparum	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.037	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.037	0.706	1
Echinococcus multilocularis	usherin	0.037	0.706	0.706
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.037	0.706	1
Onchocerca volvulus		0.037	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Schistosoma mansoni	factor for adipocyte differentiation	0.037	0.706	0.706
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.037	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Brugia malayi	SPRY domain containing protein	0.037	0.706	1
Trichomonas vaginalis	STE family protein kinase	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Echinococcus multilocularis	anosmin 1	0.037	0.706	0.706
Entamoeba histolytica	serine/threonine kinase, putative	0.0109	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.037	0.706	0.706
Trichomonas vaginalis	AGC family protein kinase	0.0109	0	0.5
Schistosoma mansoni	amidase	0.0123	0.0386	0.0386
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Echinococcus multilocularis	roundabout 2	0.037	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0109	0	0.5
Schistosoma mansoni	ephrin receptor	0.0479	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0109	0	0.5
Echinococcus multilocularis	anosmin 1	0.037	0.706	0.706
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0109	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.037	0.706	1
Brugia malayi	protein unc-22	0.037	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.037	0.706	1
Brugia malayi	Protein-tyrosine phosphatase	0.037	0.706	1
Schistosoma mansoni	titin	0.037	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Onchocerca volvulus		0.037	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus granulosus	roundabout 2	0.037	0.706	0.706
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	hypothetical protein	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Entamoeba histolytica	hypothetical protein, conserved	0.0109	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0109	0	0.5
Echinococcus granulosus	roundabout 2	0.037	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0109	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0109	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0109	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.706	1
Echinococcus granulosus	anosmin 1	0.037	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Echinococcus multilocularis	Fibronectin, type III	0.037	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0109	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0109	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.037	0.706	1
Brugia malayi	Lethal protein 805	0.037	0.706	1
Toxoplasma gondii	protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5
Giardia lamblia	Kinase, NEK	0.0109	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0109	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0109	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 11.1 nM	Inhibition of recombinant rat FAAH expressed in Escherichia coli assessed as breakdown of [14C]-oleamide by Dixon plot analysis	ChEMBL.	24456116

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3125306

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1822910