Detailed information for compound 1849858

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.45 | Formula: C25H22F2N2O4
  • H donors: 0 H acceptors: 3 LogP: 3.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OC1C=CC(C1)n1ccc(=O)n(c1=O)Cc1cc(F)cc(c1)F)CCc1ccccc1
  • InChi: 1S/C25H22F2N2O4/c26-19-12-18(13-20(27)14-19)16-29-23(30)10-11-28(25(29)32)21-7-8-22(15-21)33-24(31)9-6-17-4-2-1-3-5-17/h1-5,7-8,10-14,21-22H,6,9,15-16H2
  • InChiKey: YLRHZQFTXYIYSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0087 0.2475 0.305
Loa Loa (eye worm) hypothetical protein 0.005 0.1094 0.1349
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0807 0.1072
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0435 0.2262
Plasmodium vivax SET domain protein, putative 0.0031 0.042 0.135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1076 0.143
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0435 0.141
Mycobacterium tuberculosis Probable reductase 0.0208 0.6931 0.8892
Trichomonas vaginalis spcc417.12 protein, putative 0.0038 0.0666 0.0711
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0435 0.141
Loa Loa (eye worm) hypothetical protein 0.005 0.1093 0.1348
Brugia malayi Amino acid permease family protein 0.005 0.1094 0.1295
Loa Loa (eye worm) hypothetical protein 0.0038 0.0666 0.0808
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0224 0.7525 0.7525
Brugia malayi Fli-1 protein 0.0236 0.7945 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0038 0.0666 0.0767
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0435 0.141
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0095 0.2776 0.3689
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Loa Loa (eye worm) amino acid permease 0.005 0.1094 0.1349
Toxoplasma gondii thioredoxin reductase 0.0091 0.2629 0.9457
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0435 0.141
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.2649 0.3521
Loa Loa (eye worm) carboxylesterase 0.0038 0.0666 0.0808
Loa Loa (eye worm) hypothetical protein 0.0082 0.2293 0.2862
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1667 0.1667
Plasmodium falciparum glutathione reductase 0.0091 0.2629 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Loa Loa (eye worm) hypothetical protein 0.0042 0.0835 0.1021
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0616 0.0687
Loa Loa (eye worm) hypothetical protein 0.0053 0.1238 0.1531
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1667 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0064 0.1609 0.1609
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0435 0.1333
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0435 0.141
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0231 0.7786 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.7278 0.9157
Schistosoma mansoni gabp alpha 0.0078 0.2128 0.2128
Echinococcus multilocularis acetylcholinesterase 0.0224 0.7525 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0038 0.0666 0.0885
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0435 0.0433
Onchocerca volvulus 0.0038 0.0666 0.0309
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0435 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0231 0.7786 1
Schistosoma mansoni ets-related 0.0236 0.7945 0.7945
Echinococcus granulosus acetylcholinesterase 0.0224 0.7525 1
Schistosoma mansoni hypothetical protein 0.0024 0.0153 0.0153
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0378 0.0502
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0064 0.1609 0.1846
Brugia malayi Carboxylesterase family protein 0.0224 0.7525 0.9466
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1667 0.5894
Leishmania major trypanothione reductase 0.0091 0.2629 1
Echinococcus granulosus para nitrobenzyl esterase 0.0038 0.0666 0.0885
Echinococcus granulosus acetylcholinesterase 0.0224 0.7525 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0835 0.1021
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.2629 1
Onchocerca volvulus 0.0038 0.0666 0.0309
Loa Loa (eye worm) hypothetical protein 0.005 0.1094 0.1349
Mycobacterium tuberculosis Probable dehydrogenase 0.0208 0.6931 0.8892
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0064 0.1609 0.1609
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.042 0.0558
Echinococcus granulosus neuroligin 0.0038 0.0666 0.0885
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0435 0.0467
Loa Loa (eye worm) hypothetical protein 0.0066 0.1714 0.2131
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0095 0.2776 0.3689
Schistosoma mansoni gliotactin 0.0038 0.0666 0.0666
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0038 0.0666 0.0885
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.1535 0.1893
Mycobacterium tuberculosis Carboxylesterase LipT 0.0038 0.0666 0.0767
Schistosoma mansoni bromodomain containing protein 0.0073 0.1975 0.1975
Loa Loa (eye worm) hypothetical protein 0.0042 0.0835 0.1021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1667 1
Echinococcus multilocularis geminin 0.0182 0.5957 0.7916
Brugia malayi Melibiase family protein 0.0064 0.1609 0.1949
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0807 0.1072
Brugia malayi Pre-SET motif family protein 0.0031 0.042 0.0438
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.1535 0.9169
Onchocerca volvulus 0.0038 0.0666 0.0309
Treponema pallidum NADH oxidase 0.0032 0.0435 1
Echinococcus multilocularis solute carrier family 12 0.005 0.1094 0.1454
Mycobacterium ulcerans carboxylesterase, LipT 0.0038 0.0666 0.3712
Schistosoma mansoni ap endonuclease 0.0022 0.0075 0.0075
Plasmodium falciparum glutathione reductase 0.0032 0.0435 0.141
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.1535 0.1855
Loa Loa (eye worm) hypothetical protein 0.005 0.1094 0.1349
Echinococcus granulosus carboxylesterase 5A 0.0224 0.7525 1
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.2128 0.2829
Loa Loa (eye worm) hypothetical protein 0.0224 0.7525 0.9469
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.1822 0.2421
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0435 0.141
Schistosoma mansoni neuroligin 3 (S09 family) 0.0038 0.0666 0.0666
Brugia malayi Bromodomain containing protein 0.0044 0.0908 0.1058
Loa Loa (eye worm) hypothetical protein 0.005 0.1094 0.1349
Brugia malayi Carboxylesterase family protein 0.0038 0.0666 0.0751
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1076 0.1272
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0435 0.1333
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0435 0.141
Brugia malayi Carboxylesterase family protein 0.0038 0.0666 0.0751
Trypanosoma brucei trypanothione reductase 0.0091 0.2629 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1238 0.1478
Brugia malayi Carboxylesterase family protein 0.0224 0.7525 0.9466
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0435 0.141
Loa Loa (eye worm) hypothetical protein 0.0042 0.0835 0.1021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.1148 0.1526
Loa Loa (eye worm) acetylcholinesterase 1 0.0224 0.7525 0.9469
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.1382 0.1713
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0095 0.2776 0.2776
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1076 0.143
Trichomonas vaginalis set domain proteins, putative 0.0248 0.8384 1
Loa Loa (eye worm) carboxylesterase 0.0224 0.7525 0.9469
Loa Loa (eye worm) hypothetical protein 0.0051 0.1148 0.1417
Plasmodium vivax glutathione reductase, putative 0.0091 0.2629 1
Schistosoma mansoni acetylcholinesterase 0.0038 0.0666 0.0666
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.042 0.1277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0038 0.0666 0.0711
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0038 0.0666 0.0767
Loa Loa (eye worm) hypothetical protein 0.005 0.1094 0.1349
Loa Loa (eye worm) hypothetical protein 0.0037 0.0616 0.0745
Loa Loa (eye worm) hypothetical protein 0.0224 0.7525 0.9469
Loa Loa (eye worm) hypothetical protein 0.0038 0.0666 0.0808
Echinococcus multilocularis acetylcholinesterase 0.0224 0.7525 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0435 0.0578
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.1535 0.9169
Brugia malayi hypothetical protein 0.0038 0.0666 0.0751
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0095 0.2776 0.3689
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.042 0.042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0666 0.0666
Schistosoma mansoni ap endonuclease 0.0022 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0182 0.5957 0.5957
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1667 0.2215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1238 0.1478
Brugia malayi Ets-domain containing protein 0.0078 0.2128 0.2609
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0435 0.2262
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0235 0.0312
Brugia malayi Pre-SET motif family protein 0.0218 0.7278 0.9152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1238 0.1531
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0435 0.141
Brugia malayi Ets-domain containing protein 0.0078 0.2128 0.2609
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0435 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.2649 0.3521
Loa Loa (eye worm) hypothetical protein 0.0038 0.0666 0.0808
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1667 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1667 0.2065
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.1535 0.5715
Brugia malayi Carboxylesterase family protein 0.0038 0.0666 0.0751
Brugia malayi glutathione reductase 0.0091 0.2629 0.3246
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0038 0.0666 0.0885
Loa Loa (eye worm) hypothetical protein 0.0038 0.0666 0.0808
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0666 0.0666
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0208 0.6931 0.8892
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0435 0.0578
Loa Loa (eye worm) fli-1 protein 0.0236 0.7945 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0435 0.0458
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0095 0.2776 0.2776
Brugia malayi Thioredoxin reductase 0.0091 0.2629 0.3246
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.1535 0.1535
Onchocerca volvulus 0.0038 0.0666 0.0309
Loa Loa (eye worm) hypothetical protein 0.005 0.1094 0.1349
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0208 0.6931 0.8892
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0095 0.2776 0.2776
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0126 0.0065
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0126 0.0065
Loa Loa (eye worm) hypothetical protein 0.0047 0.1012 0.1245
Echinococcus granulosus solute carrier family 12 0.005 0.1094 0.1454
Onchocerca volvulus 0.0038 0.0666 0.0309
Loa Loa (eye worm) hypothetical protein 0.0042 0.0835 0.1021
Loa Loa (eye worm) hypothetical protein 0.005 0.1094 0.1349
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0042 0.0835 0.1021
Mycobacterium tuberculosis Probable oxidoreductase 0.0231 0.7786 1
Loa Loa (eye worm) carboxylesterase 0.0038 0.0666 0.0808
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0235 0.0312
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0435 0.0435
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0435 0.0433
Echinococcus granulosus BC026374 protein S09 family 0.0038 0.0666 0.0885
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0231 0.7786 1
Brugia malayi PHD-finger family protein 0.0029 0.0336 0.0331
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0666 0.0666
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1667 0.2215
Plasmodium falciparum thioredoxin reductase 0.0091 0.2629 1
Schistosoma mansoni hypothetical protein 0.0182 0.5957 0.5957
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0091 0.2629 0.3313
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1667 0.6233
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1667 0.1667
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0435 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.0911 0.1117
Schistosoma mansoni hypothetical protein 0.0037 0.0616 0.0616
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0153 0.016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1076 0.143
Loa Loa (eye worm) thioredoxin reductase 0.0091 0.2629 0.3287
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.042 0.042
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0075 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1076 0.1076
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.1535 0.204
Loa Loa (eye worm) hypothetical protein 0.0038 0.0666 0.0808
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0075 0.01
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0435 0.141
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0435 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0435 0.2262
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.1822 0.2421
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0235 0.0235
Schistosoma mansoni BC026374 protein (S09 family) 0.0038 0.0666 0.0666
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.1535 0.204
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0075 0.01
Plasmodium vivax thioredoxin reductase, putative 0.0091 0.2629 1
Loa Loa (eye worm) glutathione reductase 0.0091 0.2629 0.3287
Echinococcus multilocularis zinc finger protein 0.0023 0.0108 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1076 0.1076
Brugia malayi Carboxylesterase family protein 0.0038 0.0666 0.0751
Loa Loa (eye worm) hypothetical protein 0.0038 0.0666 0.0808
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.005 0.1094 0.1295
Echinococcus granulosus zinc finger protein 0.0023 0.0108 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1076 0.143
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.2128 0.2655
Schistosoma mansoni zinc finger protein 0.0023 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0042 0.0835 0.1021
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0095 0.2776 0.2776
Echinococcus multilocularis neuroligin 0.0038 0.0666 0.0885
Echinococcus multilocularis para nitrobenzyl esterase 0.0038 0.0666 0.0885
Loa Loa (eye worm) hypothetical protein 0.0064 0.1609 0.1998
Echinococcus granulosus geminin 0.0182 0.5957 0.7916
Echinococcus multilocularis carboxylesterase 5A 0.0224 0.7525 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.1148 0.1148
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0075 0.0062
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0435 0.141
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0208 0.6931 0.8892
Plasmodium falciparum thioredoxin reductase 0.0032 0.0435 0.141
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.1148 0.1526
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1076 0.1326
Loa Loa (eye worm) hypothetical protein 0.0038 0.0666 0.0808
Onchocerca volvulus 0.0248 0.8384 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0435 0.141
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.005 0.1094 0.1094
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.2128 0.2829
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0435 0.141
Toxoplasma gondii melibiase subfamily protein 0.0095 0.2776 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0208 0.6931 0.8892
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1076 0.1076
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0435 0.141

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.