Detailed information for compound 1869423

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1017.2 | Formula: C51H84O20
  • H donors: 10 H acceptors: 11 LogP: -0.98 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCC1OC(CO[C@H]2CC[C@]3([C@H](C2)CC[C@@H]2[C@@H]3C(=O)C[C@]3([C@H]2CC2C3[C@H](C)[C@]3(O2)CCC(CO3)C)C)C)C(C(C1OCOCC1OC(CO)C(C(C1O)O)COCC1OC(CO)C(C(C1O)O)CO)O)O
  • InChi: 1S/C51H84O20/c1-24-7-10-51(67-18-24)25(2)40-33(71-51)12-31-28-6-5-26-11-27(8-9-49(26,3)41(28)32(56)13-50(31,40)4)65-22-39-46(61)47(62)48(36(17-55)70-39)66-23-64-21-38-45(60)43(58)30(35(16-54)69-38)19-63-20-37-44(59)42(57)29(14-52)34(15-53)68-37/h24-31,33-48,52-55,57-62H,5-23H2,1-4H3/t24?,25-,26-,27-,28-,29?,30?,31-,33?,34?,35?,36?,37?,38?,39?,40?,41+,42?,43?,44?,45?,46?,47?,48?,49-,50-,51+/m0/s1
  • InChiKey: ZCEKEIZEKMMQLN-RSIDUPIKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0117 0.0277 0.1005
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0023 0.0035
Onchocerca volvulus 0.0934 0.2678 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0386 0.2229
Schistosoma mansoni survival motor neuron protein 0.0049 0.0075 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.0743 0.0737
Loa Loa (eye worm) hypothetical protein 0.0536 0.1507 0.5625
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0351 0.0964 0.1456
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0391 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0023 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0111 0.0414
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0122 0.0292 0.0286
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0536 0.1507 0.5625
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0023 0.0035
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.0792 1
Brugia malayi MH2 domain containing protein 0.0251 0.0669 0.2473
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0006 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0117 0.0277 0.0271
Loa Loa (eye worm) hypothetical protein 0.0275 0.074 0.2764
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0054 0.0568
Onchocerca volvulus 0.0934 0.2678 1
Onchocerca volvulus 0.0934 0.2678 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0043 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0023 0.0086
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0023 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0068 0.0133 0.3253
Brugia malayi hypothetical protein 0.0399 0.1104 0.4103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0023 0.0086
Brugia malayi hypothetical protein 0.0536 0.1507 0.5611
Loa Loa (eye worm) hypothetical protein 0.0245 0.0654 0.2442
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.034 0.4219
Onchocerca volvulus 0.0346 0.095 0.3501
Schistosoma mansoni transcription factor LCR-F1 0.0375 0.1034 0.1563
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0023 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0743 0.1123
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0023 0.0052
Brugia malayi Matrixin family protein 0.0275 0.074 0.2739
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0268
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.0669 0.2498
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0071
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0156 0.0391 0.0385
Schistosoma mansoni hypothetical protein 0.0117 0.0277 0.0419
Echinococcus granulosus GPCR family 2 0.0117 0.0277 0.041
Loa Loa (eye worm) hypothetical protein 0.0399 0.1104 0.4123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0043 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.0743 0.1114
Onchocerca volvulus Matrix metalloproteinase homolog 0.061 0.1724 0.6411
Loa Loa (eye worm) hypothetical protein 0.0335 0.0916 0.3421
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0117 0.0277 0.041
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.005 0.0066
Brugia malayi Pre-SET motif family protein 0.0068 0.0133 0.0466
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0023 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0023 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0034
Mycobacterium leprae PROBABLE HYDROLASE 0.0335 0.0916 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0117 0.0277 0.0271
Brugia malayi jmjC domain containing protein 0.0038 0.0043 0.0129
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0391 0.0109
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.074 0.2764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.0743 0.0737
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0023 0.0015
Echinococcus granulosus microtubule associated protein 2 0.2274 0.6616 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0023 0.0052
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0934 0.2678 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0023 0.0035
Entamoeba histolytica hypothetical protein 0.0375 0.1034 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1032 0.2964 0.4475
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.005 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0023 0.0086
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0391 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0019 0.0071
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0019 0.026
Onchocerca volvulus 0.0934 0.2678 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Schistosoma mansoni hypothetical protein 0.0253 0.0677 0.1024
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0023 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0087 0.0189 0.0277
Loa Loa (eye worm) hypothetical protein 0.0934 0.2678 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1032 0.2964 0.296
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0476 0.1332 0.4974
Loa Loa (eye worm) hypothetical protein 0.0536 0.1507 0.5625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0743 0.1123
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0023 0.0017
Brugia malayi jmjC domain containing protein 0.0096 0.0215 0.0773
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0536 0.1507 0.5625
Brugia malayi Matrixin family protein 0.0697 0.1981 0.7387
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0536 0.1507 0.5625
Schistosoma mansoni microtubule-associated protein tau 0.2274 0.6616 1
Brugia malayi Pre-SET motif family protein 0.0476 0.1332 0.4957
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.0743 0.1114
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.0233 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0023 0.0052
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0542 0.1526 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0087 0.0189 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0023 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0023 0.0086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0023 0.0086
Brugia malayi nuclear receptor NHR-88 0.0031 0.0023 0.0052
Schistosoma mansoni hypothetical protein 0.0049 0.0075 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0216
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0023 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0023 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0023 0.0025
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0391 1
Echinococcus multilocularis adam 17 protease 0.0195 0.0505 0.0499
Loa Loa (eye worm) hypothetical protein 0.0079 0.0164 0.0611
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0019 0.0029
Echinococcus multilocularis peregrin 0.0032 0.0027 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0023 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0023 0.0035
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0934 0.2678 1
Brugia malayi nuclear hormone receptor 0.0031 0.0023 0.0052
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0023 0.0086
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0122 0.0292 0.0432
Brugia malayi Probable ClpP-like protease 0.0156 0.0391 0.1432
Loa Loa (eye worm) hypothetical protein 0.0371 0.1022 0.3817
Entamoeba histolytica hypothetical protein 0.0375 0.1034 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0375 0.1034 0.1028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0371 0.1022 0.3796
Brugia malayi Bromodomain containing protein 0.0032 0.0027 0.0066
Echinococcus multilocularis geminin 0.0868 0.2483 0.2479
Schistosoma mansoni hypothetical protein 0.0117 0.0277 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.0409 0.1135 0.424
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0087 0.0189 0.0286
Entamoeba histolytica hypothetical protein 0.0375 0.1034 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0023 0.0025
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0355 0.0975 0.9267
Brugia malayi PHD-finger family protein 0.0029 0.0019 0.0037
Onchocerca volvulus 0.0536 0.1507 0.5594
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0536 0.1507 0.5611
Brugia malayi hypothetical protein 0.0034 0.0032 0.0087
Echinococcus multilocularis GPCR, family 2 0.0117 0.0277 0.0271
Schistosoma mansoni hypothetical protein 0.0868 0.2483 0.3753
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0023 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0068 0.0133 0.0202
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0536 0.1507 0.5611
Brugia malayi Matrixin family protein 0.0275 0.074 0.2739
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0091 0.2136
Brugia malayi steroid hormone receptor 0.0031 0.0023 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0253 0.0677 0.2529
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0536 0.1507 0.5625
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0023 0.0017
Schistosoma mansoni hypothetical protein 0.0375 0.1034 0.1563
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0157 0.0238
Onchocerca volvulus 0.0031 0.0023 0.0015
Schistosoma mansoni hypothetical protein 0.0346 0.095 0.1436
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0633 0.0627
Loa Loa (eye worm) hypothetical protein 0.0399 0.1104 0.4123
Onchocerca volvulus Huntingtin homolog 0.0245 0.0654 0.2388
Brugia malayi Bromodomain containing protein 0.0083 0.0177 0.0631
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0053 0.0047
Onchocerca volvulus 0.0542 0.1526 0.5666
Schistosoma mansoni bromodomain containing protein 0.007 0.0139 0.021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0023 0.0025
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0215 0.0316
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.034 0.4219
Echinococcus granulosus adam 0.0034 0.0032 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.0669 0.2498
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0335 0.0916 1
Onchocerca volvulus 0.0049 0.0075 0.0212
Brugia malayi Hemopexin family protein 0.0346 0.095 0.3525
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0117 0.0277 0.041
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0092 0.0203 0.0298
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0023 0.0017
Brugia malayi Matrixin family protein 0.0275 0.074 0.2739
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0023 0.0035
Brugia malayi Matrixin family protein 0.0275 0.074 0.2739
Loa Loa (eye worm) latrophilin receptor protein 2 0.0117 0.0277 0.1036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0023 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0792 1
Echinococcus multilocularis adam 0.0034 0.0032 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0117 0.0277 0.1005
Loa Loa (eye worm) hypothetical protein 0.0399 0.1104 0.4123
Loa Loa (eye worm) hypothetical protein 0.0045 0.0066 0.0245
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0054 0.0568
Loa Loa (eye worm) hypothetical protein 0.0238 0.0633 0.2363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0023 0.0025
Toxoplasma gondii hypothetical protein 0.0054 0.0091 0.2136
Onchocerca volvulus 0.0068 0.0133 0.043
Brugia malayi PHD-finger family protein 0.0028 0.0014 0.0019
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0156 0.0391 0.3642
Onchocerca volvulus 0.0934 0.2678 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0189 0.0706
Loa Loa (eye worm) hypothetical protein 0.0536 0.1507 0.5625
Brugia malayi hypothetical protein 0.0238 0.0633 0.2337
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0128 0.0184
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0023 0.0035
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0391 1
Onchocerca volvulus 0.0934 0.2678 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0277 0.1036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0536 0.1507 0.5611
Brugia malayi hypothetical protein 0.0245 0.0654 0.2416
Schistosoma mansoni peptidase Clp (S14 family) 0.0156 0.0391 0.0591
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0092 0.0203 0.0727
Schistosoma mansoni hypothetical protein 0.0117 0.0277 0.0419
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0019 0.026
Loa Loa (eye worm) hypothetical protein 0.0245 0.0654 0.2442
Loa Loa (eye worm) hypothetical protein 0.005 0.0081 0.0301
Plasmodium falciparum phd finger protein, putative 0.0029 0.0019 0.026
Brugia malayi ecdysteroid receptor 0.0031 0.0023 0.0052
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0053 0.007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0126 0.0181
Plasmodium vivax SET domain protein, putative 0.0068 0.0133 0.3253
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0019 0.026
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0023 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0375 0.1034 0.1555
Brugia malayi hypothetical protein 0.0536 0.1507 0.5611
Onchocerca volvulus Huntingtin homolog 0.0245 0.0654 0.2388
Loa Loa (eye worm) matrixin family protein 0.061 0.1724 0.6436
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0934 0.2678 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0019 0.0019
Onchocerca volvulus Matrilysin homolog 0.0275 0.074 0.2712
Onchocerca volvulus 0.0275 0.074 0.2712
Toxoplasma gondii hypothetical protein 0.0047 0.0071 0.163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0133 0.0202
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0934 0.2678 1
Entamoeba histolytica hypothetical protein 0.0375 0.1034 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0023 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0189 0.0286
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0043 0.0162
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0023 0.0025
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0195 0.0505 0.0763
Schistosoma mansoni hypothetical protein 0.0117 0.0277 0.0419
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0391 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0023 0.0025
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0023 0.0025
Echinococcus granulosus peregrin 0.0032 0.0027 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0023 0.0035
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0091 0.2136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0371 0.1022 0.3817
Brugia malayi latrophilin 2 splice variant baaae 0.0253 0.0677 0.2504
Brugia malayi hypothetical protein 0.0375 0.1034 0.384
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0743 0.1123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0189 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0276 0.0743 0.2749
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0023 0.0052
Echinococcus granulosus geminin 0.0868 0.2483 0.3747
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0023 0.0035
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0391 0.5
Loa Loa (eye worm) hypothetical protein 0.0399 0.1104 0.4123
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0054 0.0568
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.034 0.4219
Onchocerca volvulus 0.0934 0.2678 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0023 0.0052
Onchocerca volvulus 0.0934 0.2678 1
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0092 0.0203 0.0307
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0092 0.0203 0.0197
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0034 0.0032 0.0049
Brugia malayi LBP/BPI 0.0399 0.1104 0.4103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.008 0.0906
Onchocerca volvulus Matrilysin homolog 0.0685 0.1947 0.7251
Loa Loa (eye worm) matrix metalloproteinase 0.0275 0.074 0.2764
Schistosoma mansoni coup transcription factor 0.0031 0.0023 0.0035
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0037 0.0031
Brugia malayi Bromodomain containing protein 0.0043 0.0058 0.0182
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0128 0.0121
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0156 0.0391 0.0583
Loa Loa (eye worm) hypothetical protein 0.0156 0.0391 0.1461
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.0233 0.0227
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0068 0.0133 0.0127
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0023 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0371 0.1022 0.3796
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0043 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0023 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Loa Loa (eye worm) matrixin family protein 0.0697 0.1981 0.7396
Onchocerca volvulus 0.0399 0.1104 0.4081
Giardia lamblia DNA repair protein RAD52 0.0355 0.0975 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0023 0.0052
Echinococcus multilocularis microtubule associated protein 2 0.2274 0.6616 0.6614
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.0233 0.1728
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0023 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0023 0.0052
Schistosoma mansoni hypothetical protein 0.0868 0.2483 0.3753
Echinococcus granulosus adam 17 protease 0.0214 0.0562 0.0841
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0023 0.0052
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0633 0.0948
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0276 0.0743 0.2773
Onchocerca volvulus 0.0536 0.1507 0.5594
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0019 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0075 0.0249
Mycobacterium ulcerans hydrolase 0.0335 0.0916 1
Schistosoma mansoni hypothetical protein 0.0029 0.0019 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0086
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0335 0.0916 0.3399
Loa Loa (eye worm) hypothetical protein 0.0351 0.0964 0.3598
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0215 0.0209
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0156 0.0391 0.5
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0156 0.0391 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0023 0.0086
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0054 0.0568
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0023 0.0017
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0391 0.0109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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