Detailed information for compound 1871069

Basic information

Technical information
  • TDR Targets ID: 1871069
  • Name: 3-phenylpropyl (E)-6-cyclohexyl-6-methoxy-5-m ethylhex-3-enoate
  • MW: 358.514 | Formula: C23H34O3
  • H donors: 0 H acceptors: 1 LogP: 5.92 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(C(/C=C/CC(=O)OCCCc1ccccc1)C)C1CCCCC1
  • InChi: 1S/C23H34O3/c1-19(23(25-2)21-15-7-4-8-16-21)11-9-17-22(24)26-18-10-14-20-12-5-3-6-13-20/h3,5-6,9,11-13,19,21,23H,4,7-8,10,14-18H2,1-2H3/b11-9+
  • InChiKey: WFDPQRQYLWKFNQ-PKNBQFBNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-phenylpropyl (E)-6-cyclohexyl-6-methoxy-5-methyl-hex-3-enoate
  • (E)-6-cyclohexyl-6-methoxy-5-methylhex-3-enoic acid 3-phenylpropyl ester
  • (E)-6-cyclohexyl-6-methoxy-5-methyl-hex-3-enoic acid 3-phenylpropyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit beta 0.0158 1 1
Loa Loa (eye worm) tubulin beta chain 0.0069 0.3392 0.3392
Loa Loa (eye worm) BEN-1 protein 0.0158 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0158 1 1
Loa Loa (eye worm) tubulin gamma chain 0.0158 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0069 0.3392 0.3392
Brugia malayi Tubulin beta-1 chain 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Echinococcus granulosus tubulin beta 1 chain 0.0158 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0158 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0089 0.493 0.493
Leishmania major gamma-tubulin 0.0158 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0158 1 1
Entamoeba histolytica tubulin alpha chain, putative 0.0158 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0158 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0158 1 1
Leishmania major delta tubulin, putative 0.0069 0.3392 0.3392
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.493 0.493
Plasmodium falciparum tubulin epsilon chain, putative 0.0158 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Trypanosoma brucei beta tubulin 0.0158 1 1
Trypanosoma brucei tubulin gamma chain 0.0158 1 1
Loa Loa (eye worm) beta-tubulin 0.0158 1 1
Echinococcus granulosus beta tubulin 0.0158 1 1
Echinococcus multilocularis tubulin alpha chain 0.0158 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0089 0.493 0.493
Schistosoma mansoni alpha tubulin 0.0158 1 1
Echinococcus granulosus tubulin alpha chain 0.0158 1 1
Mycobacterium ulcerans cell division protein FtsZ 0.0069 0.3392 1
Trichomonas vaginalis tubulin beta chain, putative 0.0158 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0158 1 1
Loa Loa (eye worm) BEN-1 protein 0.0158 1 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Echinococcus granulosus tubulin epsilon chain 0.0158 1 1
Echinococcus multilocularis beta tubulin 0.0158 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.3392 0.3392
Leishmania major zeta tubulin, putative 0.0069 0.3392 0.3392
Echinococcus granulosus tubulin gamma 1 chain 0.0158 1 1
Brugia malayi Tubulin alpha chain 0.0069 0.3392 0.3392
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.493 0.493
Toxoplasma gondii beta tubulin 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Trichomonas vaginalis tubulin, putative 0.0089 0.493 0.493
Echinococcus multilocularis Tubulin alpha 1 chain 0.0158 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0158 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 1 1
Trypanosoma brucei beta tubulin 0.0158 1 1
Echinococcus multilocularis beta tubulin 0.0158 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0158 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0158 1 1
Echinococcus granulosus tubulin alpha chain 0.0158 1 1
Echinococcus granulosus tubulin subunit TubB 0.0158 1 1
Entamoeba histolytica tubulin gamma chain 0.0158 1 1
Giardia lamblia Beta tubulin 0.0158 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.493 0.493
Trypanosoma cruzi zeta tubulin, putative 0.0069 0.3392 0.3392
Trichomonas vaginalis tubulin beta chain, putative 0.0089 0.493 0.493
Schistosoma mansoni tubulin subunit alpha 0.0069 0.3392 0.3392
Echinococcus granulosus Tubulin alpha 1 chain 0.0158 1 1
Onchocerca volvulus 0.0089 0.493 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.0158 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0158 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0158 1 1
Leishmania major epsilon tubulin, putative 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Treponema pallidum cell division protein FtsZ 0.0069 0.3392 1
Brugia malayi Tubulin beta chain 0.0089 0.493 0.493
Leishmania major beta tubulin 0.0158 1 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0069 0.3392 1
Brugia malayi Cell division protein ftsZ 0.0069 0.3392 0.3392
Plasmodium vivax delta tubulin, putative 0.0069 0.3392 0.3392
Brugia malayi Tubulin beta chain 0.0069 0.3392 0.3392
Echinococcus granulosus beta tubulin 0.0158 1 1
Brugia malayi alpha-tubulin 0.0158 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 1 1
Giardia lamblia Epsilon tubulin 0.0069 0.3392 0.3392
Mycobacterium leprae cell division protein FtsZ 0.0069 0.3392 0.5
Trypanosoma cruzi epsilon tubulin, putative 0.0158 1 1
Giardia lamblia Beta tubulin 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0158 1 1
Trypanosoma brucei beta tubulin 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0158 1 1
Loa Loa (eye worm) hypothetical protein 0.0158 1 1
Trypanosoma cruzi tubulin delta chain 0.0069 0.3392 0.3392
Trypanosoma brucei tubulin delta chain 0.0069 0.3392 0.3392
Trypanosoma cruzi epsilon tubulin, putative 0.0158 1 1
Schistosoma mansoni tubulin subunit delta 0.0069 0.3392 0.3392
Trichomonas vaginalis tubulin gamma chain, putative 0.0158 1 1
Brugia malayi Tubulin gamma chain 0.0158 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Echinococcus granulosus tubulin delta chain 0.0069 0.3392 0.3392
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.3392 0.3392
Echinococcus multilocularis hypothetical protein 0.0158 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0158 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0069 0.3392 0.3392
Echinococcus multilocularis tubulin alpha chain 0.0158 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 1 1
Schistosoma mansoni alpha tubulin 0.0158 1 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0158 1 1
Trypanosoma brucei zeta tubulin 0.0069 0.3392 0.3392
Plasmodium vivax tubulin beta chain, putative 0.0158 1 1
Echinococcus multilocularis tubulin alpha chain 0.0158 1 1
Brugia malayi tubulin alpha chain - mouse 0.0158 1 1
Trypanosoma brucei alpha tubulin 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Echinococcus granulosus tubulin subunit beta 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0089 0.493 0.493
Leishmania major beta tubulin 0.0158 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0158 1 1
Trypanosoma cruzi zeta tubulin, putative 0.0069 0.3392 0.3392
Trichomonas vaginalis tubulin, putative 0.0089 0.493 0.493
Schistosoma mansoni tubulin subunit beta 0.0158 1 1
Giardia lamblia Alpha-tubulin 0.0158 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0069 0.3392 0.3392
Trypanosoma brucei epsilon tubulin 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Schistosoma mansoni tubulin subunit beta 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Schistosoma mansoni tubulin subunit epsilon 0.0158 1 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0158 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.0158 1 1
Echinococcus multilocularis tubulin subunit beta 0.0158 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0069 0.3392 0.3392
Echinococcus multilocularis tubulin subunit TubB 0.0158 1 1
Plasmodium falciparum tubulin gamma chain 0.0158 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Trypanosoma brucei alpha tubulin 0.0158 1 1
Plasmodium vivax tubulin epsilon chain, putative 0.0158 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0089 0.493 0.493
Schistosoma mansoni tubulin subunit beta 0.0158 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0158 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0158 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0158 1 1
Trichomonas vaginalis tubulin, putative 0.0158 1 1
Echinococcus granulosus alpha tubulin 0.0158 1 1
Giardia lamblia Delta tubulin 0.0069 0.3392 0.3392
Leishmania major alpha tubulin 0.0158 1 1
Schistosoma mansoni tubulin subunit alpha 0.0158 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0158 1 1
Echinococcus granulosus tubulin alpha chain 0.0158 1 1
Brugia malayi Tubulin alpha-2 chain 0.0158 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0158 1 1
Trypanosoma cruzi beta tubulin, putative 0.0158 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.0158 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0069 0.3392 0.3392
Schistosoma mansoni alpha tubulin 0.0158 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0158 1 1
Schistosoma mansoni tubulin subunit gamma 0.0158 1 1
Plasmodium falciparum tubulin beta chain 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Giardia lamblia Beta tubulin 0.0158 1 1
Echinococcus multilocularis tubulin delta chain 0.0069 0.3392 0.3392
Echinococcus granulosus tubulin alpha chain 0.0158 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Trypanosoma brucei epsilon tubulin 0.0158 1 1
Loa Loa (eye worm) tubulin beta chain 0.0158 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0158 1 1
Schistosoma mansoni tubulin subunit alpha 0.0158 1 1
Trypanosoma cruzi tubulin delta chain 0.0069 0.3392 0.3392
Trichomonas vaginalis tubulin beta chain, putative 0.0158 1 1
Schistosoma mansoni tubulin subunit beta 0.0158 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0158 1 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0069 0.3392 0.3392
Echinococcus granulosus tubulin beta 4A class IVa 0.0158 1 1
Brugia malayi Tubulin alpha chain 0.0158 1 1
Toxoplasma gondii beta-1 tubulin, putative 0.0158 1 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0069 0.3392 1
Toxoplasma gondii beta-tubulin, putative 0.0158 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0158 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 1 1
Echinococcus granulosus tubulin alpha 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.493 0.493
Leishmania major beta tubulin 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Plasmodium falciparum alpha tubulin 2 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Giardia lamblia Gamma tubulin 0.0158 1 1
Trichomonas vaginalis tubulin, putative 0.0069 0.3392 0.3392
Echinococcus granulosus tubulin alpha chain 0.0158 1 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0069 0.3392 0.3392
Echinococcus multilocularis tubulin epsilon chain 0.0158 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0158 1 1
Entamoeba histolytica tubulin family protein 0.0158 1 1
Echinococcus multilocularis tubulin alpha chain 0.0158 1 1
Schistosoma mansoni tubulin subunit alpha 0.0158 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.0158 1 1
Schistosoma mansoni tubulin subunit beta 0.0069 0.3392 0.3392
Leishmania major beta tubulin 0.0158 1 1
Trypanosoma brucei alpha tubulin 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0158 1 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0089 0.493 0.493
Loa Loa (eye worm) alpha-tubulin 0.0158 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0158 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0158 1 1
Brugia malayi Tubulin alpha-2 chain 0.0158 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 1 1
Trypanosoma brucei alpha tubulin, putative 0.0089 0.493 0.493
Schistosoma mansoni tubulin subunit beta 0.0158 1 1
Trypanosoma cruzi tubulin gamma chain 0.0158 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3392 0.3392
Entamoeba histolytica tubulin family protein 0.0158 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0158 1 1
Toxoplasma gondii alpha tubulin TUBA1 0.0158 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0158 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0158 1 1
Trypanosoma brucei beta tubulin 0.0158 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0158 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0158 1 1
Trypanosoma brucei epsilon tubulin 0.0158 1 1
Echinococcus multilocularis tubulin alpha chain 0.0158 1 1
Trypanosoma brucei alpha tubulin 0.0158 1 1
Giardia lamblia Alpha-tubulin 0.0158 1 1
Brugia malayi beta-tubulin, identical 0.0158 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0158 1 1
Plasmodium falciparum alpha tubulin 1 0.0158 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1
Trypanosoma brucei beta tubulin 0.0158 1 1
Echinococcus multilocularis tubulin alpha 0.0158 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.0158 1 1
Loa Loa (eye worm) alpha-tubulin 0.0158 1 1
Leishmania major alpha tubulin 0.0158 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0158 1 1
Trypanosoma brucei zeta tubulin, putative 0.0069 0.3392 0.3392
Plasmodium falciparum tubulin delta chain, putative 0.0069 0.3392 0.3392
Leishmania major alpha tubulin 0.0158 1 1
Leishmania major beta tubulin 0.0158 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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