TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 579.964 | Formula: C28H23ClFN5O6
H donors: 0 H acceptors: 4 LogP: 3.17 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COCCn1/c(=N/C(=O)c2c(C)onc2c2c(F)cccc2Cl)/c(cc2c1nc1ccccn1c2=O)C(=O)OCC
InChi: 1S/C28H23ClFN5O6/c1-4-40-28(38)17-14-16-24(31-20-10-5-6-11-34(20)27(16)37)35(12-13-39-3)25(17)32-26(36)21-15(2)41-33-23(21)22-18(29)8-7-9-19(22)30/h5-11,14H,4,12-13H2,1-3H3/b32-25+
InChiKey: LCNXGEUSJCOHAM-WGPBWIAQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Thioredoxin reductase	0.0057	0.0483	0.0885
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.013	0.138	0.8655
Echinococcus multilocularis	dual specificity	0.0106	0.1081	0.1067
Schistosoma mansoni	lamin	0.0033	0.0182	0.0167
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0106	0.1081	0.198
Trichomonas vaginalis	CMGC family protein kinase	0.0025	0.0091	0.0619
Leishmania major	cathepsin L-like protease	0.0077	0.0728	0.3632
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Leishmania major	oligopeptidase b	0.0037	0.0233	0.1109
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0037	0.0233	0.1109
Schistosoma mansoni	hypothetical protein	0.0043	0.0316	0.0301
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0521	0.0955
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0025	0.0091	0.0167
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0316	0.0301
Schistosoma mansoni	chromobox protein	0.0084	0.0815	0.0801
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0192	0.1581
Leishmania major	serine/threonine kinase-like protein, putative	0.0025	0.0091	0.0386
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.013	0.138	0.8844
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.0654	0.064
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0405	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0031	0.005
Onchocerca volvulus	Putative endochitinase	0.0164	0.1799	0.3296
Mycobacterium tuberculosis	Probable reductase	0.013	0.138	0.8844
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0815	0.7479
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0233	0.0427
Schistosoma mansoni	chitinase	0.0022	0.0048	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Brugia malayi	GSG2	0.0135	0.1435	0.2629
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0025	0.0091	0.0076
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.013	0.138	0.8844
Schistosoma mansoni	hypothetical protein	0.0205	0.2292	0.228
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0025	0.0091	0.0288
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.0233	0.2639	0.2627
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0025	0.0091	0.0167
Loa Loa (eye worm)	haspin protein kinase	0.0135	0.1435	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0048	0.0088
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0031	0.0057
Brugia malayi	jmjC domain containing protein	0.0019	0.0015	0.0028
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0017	0.0002
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0031	0.0016
Loa Loa (eye worm)	thioredoxin reductase	0.0057	0.0483	0.0885
Loa Loa (eye worm)	hypothetical protein	0.006	0.0521	0.0955
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0015	0.0028
Onchocerca volvulus	Putative endochitinase	0.0147	0.1582	0.2898
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0654	0.064
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0156	0.1691	0.1678
Plasmodium falciparum	thioredoxin reductase	0.002	0.0026	0.004
Brugia malayi	glutathione reductase	0.0057	0.0483	0.0885
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0015	0.0028
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0728	0.3632
Toxoplasma gondii	hypothetical protein	0.0233	0.2639	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0017	0.0001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.013	0.138	0.8844
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0463	0.5458	0.5451
Onchocerca volvulus		0.0033	0.0182	0.0334
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.002	0.0026	0.0047
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0017	0.0031
Echinococcus multilocularis	cysteine protease	0.002	0.0031	0.0016
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0233	0.1109
Onchocerca volvulus	Putative chitinase	0.0022	0.0048	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0017	0.0009
Brugia malayi	Cathepsin L-like precursor	0.002	0.0031	0.0057
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Schistosoma mansoni	protein kinase	0.0025	0.0091	0.0076
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0057	0.0483	0.3025
Schistosoma mansoni	hypothetical protein	0.0205	0.2292	0.228
Brugia malayi	Cathepsin L-like precursor	0.002	0.0031	0.0057
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0145	0.1558	1
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Entamoeba histolytica	protein kinase, putative	0.0106	0.1081	0.5394
Onchocerca volvulus		0.0233	0.2639	0.4835
Giardia lamblia	Kinase, CMGC DYRK	0.0106	0.1081	1
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0031	0.0016
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0017	0.0002
Echinococcus multilocularis	hypothetical protein	0.0023	0.0069	0.0053
Loa Loa (eye worm)	chitinase I	0.0147	0.1582	0.2898
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0026	0.0053
Entamoeba histolytica	chitinase, putative	0.0147	0.1582	0.797
Trichomonas vaginalis	CMGC family protein kinase	0.0025	0.0091	0.0619
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0815	0.0801
Schistosoma mansoni	hypothetical protein	0.0023	0.0069	0.0053
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.002	0.0026	0.0053
Echinococcus multilocularis	dual specificity	0.0179	0.1977	0.1964
Plasmodium falciparum	glutathione reductase	0.002	0.0026	0.004
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0017	0.0002
Loa Loa (eye worm)	prolyl oligopeptidase	0.0463	0.5458	1
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0037	0.0233	0.1109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0031	0.0057
Brugia malayi	prolyl oligopeptidase family protein	0.0463	0.5458	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Entamoeba histolytica	hypothetical protein, conserved	0.0037	0.0233	0.1037
Brugia malayi	hypothetical protein	0.0022	0.0048	0.0088
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0057	0.0483	0.0469
Onchocerca volvulus		0.002	0.0031	0.0057
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1317	0.2413
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0233	0.0829
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0654	0.064
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0233	0.0427
Schistosoma mansoni	hypothetical protein	0.0019	0.0017	0.0001
Giardia lamblia	Kinase, CAMK CAMKL	0.0025	0.0091	0.0619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Toxoplasma gondii	cathepsin CPL	0.002	0.0031	0.006
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0156	0.1691	0.8543
Entamoeba histolytica	hypothetical protein, conserved	0.0022	0.0048	0.0087
Schistosoma mansoni	lamin	0.0033	0.0182	0.0167
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0179	0.1977	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0654	0.064
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0017	0.0009
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.002	0.0026	0.004
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0017	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Entamoeba histolytica	protein kinase domain containing protein	0.0025	0.0091	0.0308
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0135	0.1435	0.1422
Entamoeba histolytica	protein kinase, putative	0.0179	0.1977	1
Schistosoma mansoni	hypothetical protein	0.0233	0.2639	0.2627
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0017	0.0001
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0015	0.0028
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0037	0.0233	0.1964
Plasmodium falciparum	MO15-related protein kinase	0.0025	0.0091	0.0288
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Plasmodium vivax	chitinase	0.0022	0.0048	0.0125
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0815	0.0801
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0106	0.1081	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2639	0.4835
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0031	0.0057
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0017	0.0009
Brugia malayi	Endochitinase	0.0164	0.1799	0.3296
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0182	0.0334
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0106	0.1081	0.5431
Plasmodium falciparum	conserved protein, unknown function	0.0233	0.2639	1
Echinococcus multilocularis	lamin dm0	0.0033	0.0182	0.0167
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0026	0.0053
Leishmania major	cathepsin L-like protease	0.002	0.0031	0.008
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0025	0.0091	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0015	0.0028
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0361	0.0662
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0037	0.0233	0.0218
Entamoeba histolytica	cell division protein kinase 2, putative	0.0025	0.0091	0.0308
Plasmodium vivax	hypothetical protein, conserved	0.0233	0.2639	1
Trypanosoma cruzi	oligopeptidase b	0.0037	0.0233	0.1109
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.002	0.0026	0.0056
Schistosoma mansoni	hypothetical protein	0.0135	0.1435	0.1422
Leishmania major	cathepsin L-like protease	0.002	0.0031	0.008
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0031	0.008
Mycobacterium ulcerans	PE-PGRS family protein	0.0022	0.0048	0.0173
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0156	0.1691	0.1678
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Echinococcus granulosus	lamin dm0	0.0033	0.0182	0.0167
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0015	0.0028
Mycobacterium tuberculosis	Probable oxidoreductase	0.0145	0.1558	1
Leishmania major	cathepsin L-like protease	0.002	0.0031	0.008
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0031	0.0016
Trichomonas vaginalis	chitinase, putative	0.0022	0.0048	0.0212
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0037	0.0233	0.1037
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0017	0.0007
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0017	0.0001
Brugia malayi	Protein kinase domain containing protein	0.0179	0.1977	0.3622
Echinococcus multilocularis	cysteine protease	0.002	0.0031	0.0016
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Onchocerca volvulus	Putative endochitinase	0.0164	0.1799	0.3296
Mycobacterium tuberculosis	Possible chitinase	0.0125	0.1317	0.8434
Brugia malayi	hypothetical protein	0.0119	0.1241	0.2274
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0106	0.1081	0.5431
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0025	0.0091	0.0619
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.002	0.0026	0.001
Loa Loa (eye worm)	glycosyl hydrolase family 18 protein	0.0022	0.0048	0.0088
Brugia malayi	Cathepsin L-like precursor	0.002	0.0031	0.0057
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0037	0.0233	0.0427
Brugia malayi	prolyl oligopeptidase family protein	0.0037	0.0233	0.0427
Brugia malayi	jmjC domain containing protein	0.0019	0.0015	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0091	0.0619
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0017	0.0031
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.0017	0.0007
Entamoeba histolytica	protein kinase domain containing protein	0.0179	0.1977	1
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0175	0.0321
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0463	0.5458	1
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0037	0.0233	0.1037
Echinococcus granulosus	GPCR family 2	0.0019	0.0017	0.0001
Schistosoma mansoni	hypothetical protein	0.0041	0.0288	0.0273
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0037	0.0233	0.1109
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0037	0.0233	0.1037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Brugia malayi	Cell division protein kinase 2	0.0025	0.0091	0.0167
Plasmodium vivax	vivapain-2	0.002	0.0031	0.006
Brugia malayi	jmjC domain containing protein	0.0071	0.0654	0.1198
Echinococcus multilocularis	Glycoside hydrolase, chitinase domain containing protein 1	0.0022	0.0048	0.0033
Trypanosoma cruzi	oligopeptidase b	0.0037	0.0233	0.1109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0031	0.005
Echinococcus multilocularis	geminin	0.0205	0.2292	0.228
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Echinococcus multilocularis	dual specificity	0.0106	0.1081	0.1067
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0182	0.0334
Brugia malayi	hypothetical protein	0.0022	0.0048	0.0088
Brugia malayi	prolyl oligopeptidase family protein	0.0156	0.1691	0.3098
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.002	0.0026	0.004
Brugia malayi	hypothetical protein	0.0135	0.1435	0.2629
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0316	0.0301
Onchocerca volvulus		0.002	0.0031	0.0057
Loa Loa (eye worm)	ctsf protein	0.002	0.0031	0.0057
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0091	0.0619
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0106	0.1081	0.4061
Schistosoma mansoni	serine/threonine protein kinase	0.0179	0.1977	0.1964
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.0728	0.3632
Leishmania major	cathepsin L-like protease	0.002	0.0031	0.008
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1954	0.3581
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0037	0.0233	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0236	0.0433
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0316	0.0301
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0017	0.003
Brugia malayi	Heterochromatin protein 1	0.0084	0.0815	0.1493
Trypanosoma cruzi	trypanothione reductase, putative	0.0057	0.0483	0.2385
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0135	0.1435	0.1422
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1081	1
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.0233	0.2639	0.2627
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0325	0.3763	0.3754
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.013	0.138	0.8844
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Loa Loa (eye worm)	cuticular endochitinase	0.0147	0.1582	0.2898
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0182	0.0167
Echinococcus granulosus	acylamino acid releasing enzyme	0.0037	0.0233	0.0218
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0025	0.0091	0.0386
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0654	0.1198
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0135	0.1435	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1954	0.3581
Echinococcus granulosus	dual specificity	0.0106	0.1081	0.1067
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0017	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0361	0.3182
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0023	0.0069	0.0053
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0031	0.0057
Plasmodium falciparum	thioredoxin reductase	0.0057	0.0483	0.1784
Trypanosoma brucei	prolyl endopeptidase	0.0037	0.0233	0.1109
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0091	0.0076
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0026	0.5
Brugia malayi	intermediate filament protein	0.0033	0.0182	0.0334
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0026	0.0053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0031	0.008
Echinococcus granulosus	thioredoxin glutathione reductase	0.0057	0.0483	0.0469
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0037	0.0233	0.0218
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0025	0.0091	0.0288
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0031	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0233	0.1964
Entamoeba histolytica	hypothetical protein	0.0043	0.0316	0.1463
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Echinococcus multilocularis	lamin	0.0033	0.0182	0.0167
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.002	0.0026	0.0053
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0025	0.0091	0.0386
Echinococcus granulosus	Glycoside hydrolase chitinase domain containing protein 1	0.0022	0.0048	0.0033
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0017	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Trichomonas vaginalis	serine/threonine kinase, putative	0.0025	0.0091	0.0619
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0156	0.1691	0.8543
Toxoplasma gondii	prolyl endopeptidase	0.0037	0.0233	0.0829
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0025	0.0091	0.0386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Mycobacterium tuberculosis	Probable dehydrogenase	0.013	0.138	0.8844
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0037	0.0233	0.0829
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Onchocerca volvulus		0.002	0.0031	0.0057
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.002	0.0026	0.001
Entamoeba histolytica	hypothetical protein	0.0179	0.1977	1
Echinococcus granulosus	dual specificity	0.0106	0.1081	0.1067
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0233	0.1109
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.0815	0.1493
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0156	0.1691	0.1678
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0179	0.1977	0.3622
Echinococcus granulosus	chromobox protein 1	0.0084	0.0815	0.0801
Loa Loa (eye worm)	fibroinase	0.002	0.0031	0.0057
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0135	0.1435	0.1422
Entamoeba histolytica	protein kinase, putative	0.0179	0.1977	1
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Brugia malayi	Cathepsin L-like precursor	0.002	0.0031	0.0057
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.0525	0.2601
Toxoplasma gondii	thioredoxin reductase	0.0057	0.0483	0.1784
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0728	0.3632
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0031	0.0057
Giardia lamblia	Kinase, CAMK CAMKL	0.0025	0.0091	0.0619
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.002	0.0026	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0233	0.0427
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1081	1
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1081	1
Onchocerca volvulus		0.002	0.0031	0.0057
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Leishmania major	cathepsin L-like protease	0.002	0.0031	0.008
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Entamoeba histolytica	hypothetical protein	0.0023	0.0069	0.0193
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.002	0.0026	0.0053
Trypanosoma brucei	protein kinase, putative	0.0025	0.0091	0.0386
Plasmodium falciparum	peptidase, putative	0.0037	0.0233	0.0829
Schistosoma mansoni	serine/threonine kinase	0.0025	0.0091	0.0076
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0031	0.0016
Echinococcus granulosus	prolyl endopeptidase	0.0037	0.0233	0.0218
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0182	0.0334
Echinococcus granulosus	chromobox protein 1	0.0084	0.0815	0.0801
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.002	0.0026	0.001
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0361	0.3182
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0288	0.0527
Treponema pallidum	NADH oxidase	0.002	0.0026	0.5
Plasmodium falciparum	glutathione reductase	0.0057	0.0483	0.1784
Plasmodium vivax	glutathione reductase, putative	0.0057	0.0483	0.1784
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0179	0.1977	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0031	0.0016
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0179	0.1977	1
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0521	0.0955
Brugia malayi	chromobox protein homolog 3	0.0047	0.0361	0.0662
Onchocerca volvulus		0.0033	0.0182	0.0334
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0037	0.0233	0.0218
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0017	0.003
Entamoeba histolytica	protein kinase domain containing protein	0.0106	0.1081	0.5394
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0037	0.0233	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2639	0.4835
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0182	0.0334
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0646	0.3214
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Brugia malayi	jmjC domain containing protein	0.0019	0.0015	0.0028
Onchocerca volvulus		0.002	0.0031	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0048	0.0088
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0037	0.0233	0.1109
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0025	0.0091	0.0076
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0325	0.3763	0.3754
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Giardia lamblia	Kinase, CAMK CAMKL	0.0025	0.0091	0.0619
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0031	0.0016
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0026	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.0654	0.064
Echinococcus granulosus	lamin	0.0033	0.0182	0.0167
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0037	0.0233	0.1037
Brugia malayi	Endochitinase	0.0022	0.0048	0.0088
Loa Loa (eye worm)	microfilarial chitinase	0.0143	0.1534	0.281
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Brugia malayi	Cathepsin L-like precursor	0.002	0.0031	0.0057
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0031	0.0016
Brugia malayi	jmjC domain containing protein	0.0071	0.0654	0.1198
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0156	0.1691	0.8543
Onchocerca volvulus	Putative endochitinase	0.0164	0.1799	0.3296
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0025	0.0091	0.0167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.0654	0.064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.002	0.0026	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0145	0.1558	1
Echinococcus granulosus	geminin	0.0205	0.2292	0.228
Brugia malayi	prolyl oligopeptidase family protein	0.0037	0.0233	0.0427
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0017	0.0002
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0521	0.0955
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0192	0.1581
Loa Loa (eye worm)	haspin protein kinase	0.0135	0.1435	0.2629
Leishmania major	trypanothione reductase	0.0057	0.0483	0.2385
Brugia malayi	endochitinase	0.0147	0.1582	0.2898
Brugia malayi	jmjC domain containing protein	0.0019	0.0015	0.0028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0026	0.0053
Schistosoma mansoni	hypothetical protein	0.0019	0.0017	0.0001
Schistosoma mansoni	hypothetical protein	0.0019	0.0017	0.0001
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1081	1
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0815	0.7479
Onchocerca volvulus	Putative endochitinase	0.0022	0.0048	0.0088
Entamoeba histolytica	hypothetical protein	0.0043	0.0316	0.1463
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0156	0.1691	0.8543
Leishmania major	chitinase	0.0147	0.1582	0.7986
Trichomonas vaginalis	CMGC family protein kinase	0.0025	0.0091	0.0619
Trypanosoma brucei	trypanothione reductase	0.0057	0.0483	0.2385
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0025	0.0091	0.0619
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0463	0.5458	0.5451
Brugia malayi	Protein kinase domain containing protein	0.0025	0.0091	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1241	0.2274
Trypanosoma cruzi	prolyl endopeptidase	0.0037	0.0233	0.1109
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0031	0.006
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0037	0.0233	0.1964
Brugia malayi	hypothetical protein	0.0043	0.0316	0.0579
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0091	0.0619
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0017	0.0001
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0135	0.1435	0.1422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0025	0.0091	0.0076
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0031	0.0057
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.002	0.0026	0.004
Brugia malayi	Cathepsin L-like precursor	0.002	0.0031	0.0057
Loa Loa (eye worm)	hypothetical protein	0.002	0.0031	0.0057
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.002	0.0026	0.004
Toxoplasma gondii	hypothetical protein	0.0037	0.0233	0.0829
Schistosoma mansoni	serine/threonine protein kinase	0.0106	0.1081	0.1067
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0145	0.1558	1
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0325	0.3763	0.3754
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0025	0.0091	0.0076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0017	0.0002
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.0654	0.064
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0015	0.0028
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Echinococcus granulosus	dual specificity	0.0179	0.1977	0.1964
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0463	0.5458	0.5451
Echinococcus multilocularis	prolyl endopeptidase	0.0037	0.0233	0.0218
Onchocerca volvulus	Putative endochitinase	0.0147	0.1582	0.2898
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0156	0.1691	0.6388
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0091	0.0619
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0179	0.1977	1
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0037	0.0233	0.1109
Echinococcus multilocularis	cyclin dependent kinase 9	0.0025	0.0091	0.0076
Echinococcus granulosus	mitogen activated protein kinase 15	0.0025	0.0091	0.0076
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0037	0.0233	0.0218
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0031	0.006
Mycobacterium ulcerans	chitinase/cellulase	0.0125	0.1317	1
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1081	1
Echinococcus granulosus	cathepsin l1	0.002	0.0031	0.0016
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0017	0.0001
Plasmodium vivax	vivapain-2	0.002	0.0031	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0017	0.0007
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0025	0.0091	0.0386
Leishmania major	cathepsin L-like protease	0.0077	0.0728	0.3632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0091	0.0619
Brugia malayi	endochitinase	0.0164	0.1799	0.3296
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Mycobacterium ulcerans	chitinase/cellulase	0.0125	0.1317	1
Echinococcus granulosus	dual specificity	0.0106	0.1081	0.1067
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0037	0.0233	0.1964
Trichomonas vaginalis	CMGC family protein kinase	0.0025	0.0091	0.0619
Trypanosoma cruzi	trypanothione reductase, putative	0.002	0.0026	0.0053
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0017	0.0031
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0037	0.0233	0.1964
Mycobacterium tuberculosis	Probable peptidase	0.0037	0.0233	0.1401
Leishmania major	cathepsin L-like protease	0.0077	0.0728	0.3632
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0017	0.0001
Echinococcus granulosus	intermediate filament protein	0.0033	0.0182	0.0167
Echinococcus multilocularis	dual specificity	0.0106	0.1081	0.1067
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0017	0.0009
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0728	0.3632
Echinococcus multilocularis	musashi	0.0033	0.0182	0.0167
Loa Loa (eye worm)	prolyl oligopeptidase	0.0037	0.0233	0.0427
Onchocerca volvulus		0.002	0.0031	0.0057
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.002	0.0026	0.004
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0288	0.0527
Schistosoma mansoni	chromobox protein	0.0084	0.0815	0.0801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0156	0.1691	0.8543
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0037	0.0233	0.1401
Plasmodium vivax	thioredoxin reductase, putative	0.0057	0.0483	0.1784
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0031	0.006
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0017	0.003
Onchocerca volvulus		0.0233	0.2639	0.4835
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Plasmodium falciparum	chitinase	0.0022	0.0048	0.0125
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0022	0.0048	0.0088
Echinococcus granulosus	cyclin dependent kinase 9	0.0025	0.0091	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0361	0.0662
Entamoeba histolytica	hypothetical protein	0.0043	0.0316	0.1463
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0017	0.0002
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0026	0.0053
Onchocerca volvulus		0.0037	0.0236	0.0433
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0405	0.3598
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1081	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.0233	0.2639	0.4835
Loa Loa (eye worm)	glutathione reductase	0.0057	0.0483	0.0885
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0022	0.0048	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Entamoeba histolytica	hypothetical protein	0.0043	0.0316	0.1463
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0091	0.0619
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0037	0.0233	0.1605
Trypanosoma brucei	oligopeptidase b	0.0037	0.0233	0.1109
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0037	0.0233	0.0218
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0106	0.1081	0.198
Brugia malayi	prolyl oligopeptidase family protein	0.0037	0.0233	0.0427
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0031	0.005
Loa Loa (eye worm)	haspin protein kinase	0.0137	0.1457	0.267
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0728	0.3632
Onchocerca volvulus		0.002	0.0031	0.0057
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0037	0.0233	0.1109
Loa Loa (eye worm)	cysteine protease	0.002	0.0031	0.0057
Toxoplasma gondii	NADPH-glutathione reductase	0.002	0.0026	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0031	0.005
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0405	0.3598
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0017	0.0009

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0032 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.5805 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.2213 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	5.8584 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	47.7548 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3197839

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1877464