Detailed information for compound 1877464

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 579.964 | Formula: C28H23ClFN5O6
  • H donors: 0 H acceptors: 4 LogP: 3.17 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCn1/c(=N/C(=O)c2c(C)onc2c2c(F)cccc2Cl)/c(cc2c1nc1ccccn1c2=O)C(=O)OCC
  • InChi: 1S/C28H23ClFN5O6/c1-4-40-28(38)17-14-16-24(31-20-10-5-6-11-34(20)27(16)37)35(12-13-39-3)25(17)32-26(36)21-15(2)41-33-23(21)22-18(29)8-7-9-19(22)30/h5-11,14H,4,12-13H2,1-3H3/b32-25+
  • InChiKey: LCNXGEUSJCOHAM-WGPBWIAQSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0037 0.0233 0.1109
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0057
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0182 0.0334
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.003
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0106 0.1081 0.5431
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0815 0.7479
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Schistosoma mansoni serine/threonine kinase 0.0025 0.0091 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Brugia malayi GSG2 0.0135 0.1435 0.2629
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0025 0.0091 0.0386
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0048 0.0087
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0031 0.008
Onchocerca volvulus 0.002 0.0031 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Schistosoma mansoni hypothetical protein 0.0023 0.0069 0.0053
Trypanosoma cruzi prolyl endopeptidase 0.0037 0.0233 0.1109
Brugia malayi jmjC domain containing protein 0.0071 0.0654 0.1198
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.0001
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0233 0.2639 0.2627
Loa Loa (eye worm) hypothetical protein 0.006 0.0521 0.0955
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0017 0.0031
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0483 0.0885
Plasmodium falciparum MO15-related protein kinase 0.0025 0.0091 0.0288
Echinococcus multilocularis dual specificity 0.0106 0.1081 0.1067
Schistosoma mansoni hypothetical protein 0.0135 0.1435 0.1422
Echinococcus granulosus dual specificity 0.0106 0.1081 0.1067
Entamoeba histolytica protein kinase, putative 0.0179 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.1954 0.3581
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0233 0.2639 0.4835
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0654 0.064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0088
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0037 0.0233 0.1037
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0026 0.004
Brugia malayi chromobox protein homolog 3 0.0047 0.0361 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0192 0.1581
Echinococcus multilocularis dual specificity 0.0106 0.1081 0.1067
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.138 0.8844
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0037 0.0233 0.0218
Echinococcus multilocularis acylamino acid releasing enzyme 0.0037 0.0233 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) hypothetical protein 0.0233 0.2639 0.4835
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi oligopeptidase b 0.0037 0.0233 0.1109
Loa Loa (eye worm) hypothetical protein 0.0177 0.1954 0.3581
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0405 0.0742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0017 0.003
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0106 0.1081 0.198
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0037 0.0233 0.1109
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1081 0.1067
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0031 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.1977 0.1964
Brugia malayi hypothetical protein 0.0022 0.0048 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni chromobox protein 0.0084 0.0815 0.0801
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0037 0.0233 0.1037
Plasmodium vivax glutathione reductase, putative 0.0057 0.0483 0.1784
Plasmodium falciparum peptidase, putative 0.0037 0.0233 0.0829
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0192 0.1581
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) haspin protein kinase 0.0137 0.1457 0.267
Echinococcus granulosus GPCR family 2 0.0019 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Brugia malayi endochitinase 0.0147 0.1582 0.2898
Onchocerca volvulus 0.002 0.0031 0.0057
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0037 0.0233 0.1109
Echinococcus granulosus serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Trichomonas vaginalis chitinase, putative 0.0022 0.0048 0.0212
Loa Loa (eye worm) prolyl oligopeptidase 0.0463 0.5458 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.138 0.8844
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0156 0.1691 0.8543
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0361 0.3182
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0025 0.0091 0.0167
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0031 0.0016
Brugia malayi prolyl oligopeptidase family protein 0.0156 0.1691 0.3098
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.1977 1
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Echinococcus granulosus Dipeptidyl peptidase 9 0.0156 0.1691 0.1678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Plasmodium vivax vivapain-2 0.002 0.0031 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0009
Loa Loa (eye worm) haspin protein kinase 0.0135 0.1435 0.2629
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma brucei oligopeptidase b 0.0037 0.0233 0.1109
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Onchocerca volvulus 0.002 0.0031 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0037 0.0233 0.0218
Plasmodium vivax chitinase 0.0022 0.0048 0.0125
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0031 0.0057
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0026 0.004
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0025 0.0091 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Schistosoma mansoni lamin 0.0033 0.0182 0.0167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.0001
Toxoplasma gondii hypothetical protein 0.0233 0.2639 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0028
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Entamoeba histolytica protein kinase domain containing protein 0.0179 0.1977 1
Brugia malayi hypothetical protein 0.0043 0.0316 0.0579
Schistosoma mansoni lamin 0.0033 0.0182 0.0167
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) fibroinase 0.002 0.0031 0.0057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0233 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Brugia malayi prolyl oligopeptidase family protein 0.0037 0.0233 0.0427
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0017 0.0007
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0037 0.0233 0.1401
Brugia malayi Protein kinase domain containing protein 0.0025 0.0091 0.0167
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0007
Onchocerca volvulus 0.002 0.0031 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Brugia malayi glutathione reductase 0.0057 0.0483 0.0885
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0463 0.5458 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0088
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0026 0.001
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0156 0.1691 0.6388
Echinococcus multilocularis lamin 0.0033 0.0182 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0728 0.3632
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0728 0.3632
Loa Loa (eye worm) cuticular endochitinase 0.0147 0.1582 0.2898
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0233 0.2639 0.2627
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0091 0.0619
Plasmodium vivax vivapain-2 0.002 0.0031 0.006
Loa Loa (eye worm) cysteine protease 0.002 0.0031 0.0057
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0026 0.0053
Giardia lamblia Alanyl dipeptidyl peptidase 0.0037 0.0233 0.1964
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0654 0.064
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0646 0.3214
Loa Loa (eye worm) hypothetical protein 0.0037 0.0236 0.0433
Brugia malayi prolyl oligopeptidase family protein 0.0037 0.0233 0.0427
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0025 0.0091 0.0386
Echinococcus granulosus serine:threonine protein kinase NLK 0.0025 0.0091 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0463 0.5458 0.5451
Onchocerca volvulus 0.0033 0.0182 0.0334
Onchocerca volvulus 0.002 0.0031 0.0057
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0031 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0026 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Schistosoma mansoni chitinase 0.0022 0.0048 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0031 0.005
Schistosoma mansoni hypothetical protein 0.0205 0.2292 0.228
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0017 0.0009
Onchocerca volvulus Cathepsin F homolog 0.002 0.0031 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Onchocerca volvulus 0.0033 0.0182 0.0334
Echinococcus granulosus chromobox protein 1 0.0084 0.0815 0.0801
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0483 0.3025
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0463 0.5458 0.5451
Onchocerca volvulus 0.002 0.0031 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) chitinase I 0.0147 0.1582 0.2898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0361 0.0662
Onchocerca volvulus 0.0233 0.2639 0.4835
Loa Loa (eye worm) hypothetical protein 0.0047 0.0361 0.0662
Echinococcus granulosus dual specificity 0.0106 0.1081 0.1067
Entamoeba histolytica prolyl oligopeptidase family protein 0.0037 0.0233 0.1037
Trypanosoma brucei protein kinase, putative 0.0025 0.0091 0.0386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0017 0.0031
Echinococcus multilocularis lamin dm0 0.0033 0.0182 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Leishmania major serine/threonine kinase-like protein, putative 0.0025 0.0091 0.0386
Onchocerca volvulus Putative chitinase 0.0022 0.0048 0.0088
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0815 0.1493
Trypanosoma brucei prolyl endopeptidase 0.0037 0.0233 0.1109
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0025 0.0091 0.0076
Echinococcus granulosus prolyl endopeptidase 0.0037 0.0233 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0031 0.005
Entamoeba histolytica hypothetical protein 0.0179 0.1977 1
Brugia malayi hypothetical protein 0.0022 0.0048 0.0088
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0026 0.0053
Schistosoma mansoni hypothetical protein 0.0233 0.2639 0.2627
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0521 0.0955
Echinococcus multilocularis musashi 0.0033 0.0182 0.0167
Trypanosoma brucei prolyl oligopeptidase, putative 0.0037 0.0233 0.1109
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Onchocerca volvulus Cathepsin L homolog 0.002 0.0031 0.0057
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0179 0.1977 1
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0025 0.0091 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0026 0.5
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0106 0.1081 0.4061
Mycobacterium tuberculosis Probable peptidase 0.0037 0.0233 0.1401
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0106 0.1081 0.5431
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0325 0.3763 0.3754
Brugia malayi Glycosyl hydrolases family 18 protein 0.0022 0.0048 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0288 0.0527
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Loa Loa (eye worm) glutathione reductase 0.0057 0.0483 0.0885
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0037 0.0233 0.1109
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0023 0.0069 0.0053
Schistosoma mansoni protein kinase 0.0025 0.0091 0.0076
Mycobacterium ulcerans PE-PGRS family protein 0.0022 0.0048 0.0173
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0233 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0119 0.1241 0.2274
Entamoeba histolytica hypothetical protein 0.0023 0.0069 0.0193
Echinococcus granulosus cathepsin l1 0.002 0.0031 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0031 0.0016
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0179 0.1977 1
Echinococcus multilocularis dual specificity 0.0106 0.1081 0.1067
Trichomonas vaginalis serine/threonine kinase, putative 0.0025 0.0091 0.0619
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.138 0.8844
Entamoeba histolytica chitinase, putative 0.0147 0.1582 0.797
Brugia malayi Endochitinase 0.0164 0.1799 0.3296
Entamoeba histolytica prolyl oligopeptidase family protein 0.0037 0.0233 0.1037
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0025 0.0091 0.0386
Onchocerca volvulus Putative endochitinase 0.0164 0.1799 0.3296
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0022 0.0048 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0233 0.1109
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0026 0.0056
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0026 0.004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0483 0.0469
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0182 0.0334
Trypanosoma cruzi oligopeptidase b 0.0037 0.0233 0.1109
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0026 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0091 0.0619
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.1977 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0031 0.006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1558 1
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0022 0.0048 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0091 0.0619
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0037 0.0233 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0031 0.0016
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0017 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Onchocerca volvulus 0.002 0.0031 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Brugia malayi Endochitinase 0.0022 0.0048 0.0088
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0026 0.004
Leishmania major chitinase 0.0147 0.1582 0.7986
Leishmania major cathepsin L-like protease 0.0077 0.0728 0.3632
Brugia malayi prolyl oligopeptidase family protein 0.0463 0.5458 1
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0525 0.2601
Onchocerca volvulus Cathepsin L homolog 0.002 0.0031 0.0057
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0031 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0091 0.0076
Mycobacterium ulcerans chitinase/cellulase 0.0125 0.1317 1
Brugia malayi cyclin-dependent kinase 7 homolog 0.0025 0.0091 0.0167
Echinococcus multilocularis GPCR, family 2 0.0019 0.0017 0.0001
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0037 0.0233 0.1964
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0037 0.0233 0.0218
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0728 0.3632
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.1081 0.5394
Brugia malayi endochitinase 0.0164 0.1799 0.3296
Entamoeba histolytica protein kinase, putative 0.0179 0.1977 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0017 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Onchocerca volvulus Putative endochitinase 0.0164 0.1799 0.3296
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0233 0.1037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0521 0.0955
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Entamoeba histolytica protein kinase, putative 0.0106 0.1081 0.5394
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0025 0.0091 0.0386
Brugia malayi Glycosyl hydrolases family 18 protein 0.0022 0.0048 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0156 0.1691 0.8543
Echinococcus granulosus intermediate filament protein 0.0033 0.0182 0.0167
Loa Loa (eye worm) haspin protein kinase 0.0135 0.1435 0.2629
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0037 0.0233 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus granulosus cyclin dependent kinase 9 0.0025 0.0091 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0316 0.0301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0028
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0026 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Plasmodium falciparum chitinase 0.0022 0.0048 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0017 0.003
Plasmodium falciparum glutathione reductase 0.0057 0.0483 0.1784
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Mycobacterium tuberculosis Possible chitinase 0.0125 0.1317 0.8434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0028
Leishmania major cathepsin L-like protease 0.0077 0.0728 0.3632
Plasmodium vivax hypothetical protein, conserved 0.0233 0.2639 1
Brugia malayi Thioredoxin reductase 0.0057 0.0483 0.0885
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Entamoeba histolytica cell division protein kinase 2, putative 0.0025 0.0091 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0405 0.3598
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0031 0.0016
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0037 0.0233 0.1109
Loa Loa (eye worm) hypothetical protein 0.0233 0.2639 0.4835
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0325 0.3763 0.3754
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0521 0.0955
Echinococcus granulosus chromobox protein 1 0.0084 0.0815 0.0801
Schistosoma mansoni chromobox protein 0.0084 0.0815 0.0801
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0025 0.0091 0.0619
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0405 0.3598
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis cysteine protease 0.002 0.0031 0.0016
Echinococcus multilocularis prolyl endopeptidase 0.0037 0.0233 0.0218
Echinococcus multilocularis hypothetical protein 0.0023 0.0069 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0233 0.0829
Plasmodium falciparum conserved protein, unknown function 0.0233 0.2639 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0031 0.0016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0026 0.0053
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.138 0.8844
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0037 0.0233 0.1605
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0031 0.0057
Echinococcus granulosus dual specificity 0.0106 0.1081 0.1067
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0026 0.0053
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0654 0.064
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0025 0.0091 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Schistosoma mansoni hypothetical protein 0.0043 0.0316 0.0301
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1558 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.138 0.8844
Loa Loa (eye worm) hypothetical protein 0.0037 0.0233 0.0427
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0288 0.0527
Giardia lamblia Kinase, CMGC DYRK 0.0106 0.1081 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma brucei trypanothione reductase 0.0057 0.0483 0.2385
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0017 0.003
Onchocerca volvulus Putative endochitinase 0.0147 0.1582 0.2898
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0654 0.064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Brugia malayi jmjC domain containing protein 0.0071 0.0654 0.1198
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0031 0.006
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0025 0.0091 0.0386
Brugia malayi prolyl oligopeptidase family protein 0.0037 0.0233 0.0427
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0025 0.0091 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus multilocularis cyclin dependent kinase 9 0.0025 0.0091 0.0076
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0483 0.2385
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0025 0.0091 0.0288
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0026 0.0053
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0037 0.0233 0.0829
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0026 0.0047
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0017 0.0007
Toxoplasma gondii thioredoxin reductase 0.0057 0.0483 0.1784
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0179 0.1977 0.3622
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Onchocerca volvulus Putative endochitinase 0.0147 0.1582 0.2898
Brugia malayi intermediate filament protein 0.0033 0.0182 0.0334
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0156 0.1691 0.1678
Treponema pallidum NADH oxidase 0.002 0.0026 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0463 0.5458 0.5451
Echinococcus granulosus mitogen activated protein kinase 15 0.0025 0.0091 0.0076
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0022 0.0048 0.0088
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0026 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Plasmodium falciparum glutathione reductase 0.002 0.0026 0.004
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0156 0.1691 0.8543
Schistosoma mansoni intermediate filament proteins 0.0033 0.0182 0.0167
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0483 0.1784
Brugia malayi hypothetical protein 0.0135 0.1435 0.2629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Leishmania major cathepsin L-like protease 0.0077 0.0728 0.3632
Leishmania major trypanothione reductase 0.0057 0.0483 0.2385
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.138 0.8655
Giardia lamblia Alanyl dipeptidyl peptidase 0.0037 0.0233 0.1964
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Onchocerca volvulus Putative endochitinase 0.0164 0.1799 0.3296
Mycobacterium tuberculosis Probable reductase 0.013 0.138 0.8844
Mycobacterium ulcerans chitinase/cellulase 0.0125 0.1317 1
Onchocerca volvulus 0.0037 0.0236 0.0433
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0233 0.1109
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0728 0.3632
Schistosoma mansoni hypothetical protein 0.0041 0.0288 0.0273
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0654 0.064
Onchocerca volvulus 0.0233 0.2639 0.4835
Brugia malayi isocitrate dehydrogenase 0.0019 0.0017 0.0031
Trichomonas vaginalis protein kinase atmrk1, putative 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis cysteine protease 0.002 0.0031 0.0016
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0156 0.1691 0.8543
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) prolyl oligopeptidase 0.0037 0.0233 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0031 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Schistosoma mansoni hypothetical protein 0.0205 0.2292 0.228
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0017 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1558 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0654 0.064
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0156 0.1691 0.1678
Echinococcus multilocularis chromobox protein 1 0.0084 0.0815 0.0801
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0007
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0156 0.1691 0.8543
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0321
Onchocerca volvulus Prolyl endopeptidase homolog 0.0037 0.0233 0.0427
Brugia malayi Protein kinase domain containing protein 0.0179 0.1977 0.3622
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0316 0.0301
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0026 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0654 0.064
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0017 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0654 0.1198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0483 0.0469
Echinococcus granulosus geminin 0.0205 0.2292 0.228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus granulosus lamin dm0 0.0033 0.0182 0.0167
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0233 0.1964
Echinococcus granulosus lamin 0.0033 0.0182 0.0167
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0031 0.0057
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0037 0.0233 0.1964
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0026 0.004
Leishmania major oligopeptidase b 0.0037 0.0233 0.1109
Loa Loa (eye worm) ctsf protein 0.002 0.0031 0.0057
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1558 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0009
Brugia malayi hypothetical protein 0.0119 0.1241 0.2274
Loa Loa (eye worm) microfilarial chitinase 0.0143 0.1534 0.281
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.0091 0.0308
Brugia malayi Cell division protein kinase 2 0.0025 0.0091 0.0167
Echinococcus granulosus serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0106 0.1081 0.5431
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0316 0.0301
Plasmodium falciparum thioredoxin reductase 0.002 0.0026 0.004
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0325 0.3763 0.3754
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0026 0.5
Entamoeba histolytica prolyl oligopeptidase family protein 0.0037 0.0233 0.1037
Echinococcus granulosus dual specificity 0.0179 0.1977 0.1964
Echinococcus multilocularis dual specificity 0.0179 0.1977 0.1964
Toxoplasma gondii hypothetical protein 0.0037 0.0233 0.0829
Echinococcus granulosus serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Brugia malayi Heterochromatin protein 1 0.0084 0.0815 0.1493
Toxoplasma gondii prolyl endopeptidase 0.0037 0.0233 0.0829
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0815 0.7479
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0037 0.0233 0.0218
Loa Loa (eye worm) hypothetical protein 0.0125 0.1317 0.2413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0026 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0361 0.3182
Toxoplasma gondii cathepsin CPL 0.002 0.0031 0.006
Echinococcus multilocularis geminin 0.0205 0.2292 0.228
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0026 0.5
Echinococcus multilocularis chromobox protein 1 0.0084 0.0815 0.0801
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0026 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Leishmania major cysteine peptidase A (CPA) 0.002 0.0031 0.008
Onchocerca volvulus Putative endochitinase 0.0022 0.0048 0.0088
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0106 0.1081 0.198
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0182 0.0334
Plasmodium falciparum thioredoxin reductase 0.0057 0.0483 0.1784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0032 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5805 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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