TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.804 | Formula: C25H22Cl3NO6
H donors: 2 H acceptors: 5 LogP: 5.9 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: CC(OC(=O)C1=C(C)N(Cc2ccc(c(c2)Cl)Cl)C(=C(C1c1ccccc1Cl)C(=O)O)C(=O)O)C
InChi: 1S/C25H22Cl3NO6/c1-12(2)35-25(34)19-13(3)29(11-14-8-9-17(27)18(28)10-14)22(24(32)33)21(23(30)31)20(19)15-6-4-5-7-16(15)26/h4-10,12,20H,11H2,1-3H3,(H,30,31)(H,32,33)
InChiKey: VDQBVXYOYYYIBB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References
Homo sapiens	phosphorylase, glycogen	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	intermediate filament protein	0.0022	0.0157	0.0405
Leishmania major	mitochondrial DNA polymerase beta	0.0229	0.3386	1
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0014	0.0033	0.0023
Trichomonas vaginalis	chromobox protein, putative	0.0019	0.0115	0.027
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0019	0.0115	0.2722
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0041	0.0106
Loa Loa (eye worm)	transcription factor SMAD2	0.009	0.1229	0.3164
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0116	0.0299
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0019	0.0115	0.2722
Echinococcus granulosus	Niemann Pick C1 protein	0.0079	0.1055	0.1233
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0536	0.1359
Brugia malayi	SET domain containing protein	0.0019	0.0115	0.0295
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0115	0.2897
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0014	0.0041	0.0184
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0035	0.0359	0.0412
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0035	0.0359	0.0924
Mycobacterium tuberculosis	Probable dehydrogenase	0.0081	0.1078	0.633
Schistosoma mansoni	survival motor neuron protein	0.004	0.0439	0.0507
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0116	0.063
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0115	0.027
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.009	0.1219	0.7163
Trichomonas vaginalis	chromobox protein, putative	0.0116	0.1627	0.4174
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0048	0.0568	0.0659
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0081	0.1078	0.633
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0021	0.0139	0.0152
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Mycobacterium ulcerans	hypothetical protein	0.0121	0.1698	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0113	0.1585	0.1859
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0121	0.1698	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0116	0.0299
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0832	0.2123
Schistosoma mansoni	hypothetical protein	0.0019	0.0115	0.0123
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0019	0.0115	0.0123
Trichomonas vaginalis	chromobox protein, putative	0.0019	0.0115	0.027
Echinococcus granulosus	lamin dm0	0.0022	0.0157	0.0174
Entamoeba histolytica	hypothetical protein	0.0029	0.027	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0707	0.1819
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0261	0.3883	0.3877
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2862	0.7371
Entamoeba histolytica	glycogen phosphorylase, putative	0.0113	0.1576	0.3878
Onchocerca volvulus		0.004	0.0439	0.0862
Mycobacterium tuberculosis	Probable oxidoreductase	0.009	0.1219	0.7163
Brugia malayi	Heterochromatin protein 1	0.0116	0.1627	0.4189
Echinococcus granulosus	thioredoxin glutathione reductase	0.0036	0.0378	0.0435
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0115	0.027
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0019	0.0116	0.063
Plasmodium falciparum	thioredoxin reductase	0.0035	0.0371	1
Toxoplasma gondii	thioredoxin reductase	0.0035	0.0371	0.9397
Echinococcus granulosus	zinc finger protein	0.0016	0.0064	0.0064
Echinococcus granulosus	intermediate filament protein	0.0022	0.0157	0.0174
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0115	0.2897
Leishmania major	4-coumarate:coa ligase-like protein	0.0019	0.0116	0.0315
Echinococcus multilocularis	musashi	0.0022	0.0157	0.0147
Schistosoma mansoni	lamin	0.0022	0.0157	0.0174
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0909	0.2321
Echinococcus multilocularis	microtubule associated protein 2	0.0556	0.8483	0.8481
Mycobacterium tuberculosis	Probable reductase	0.0081	0.1078	0.633
Schistosoma mansoni	chromobox protein	0.0019	0.0115	0.0123
Schistosoma mansoni	microtubule-associated protein tau	0.0556	0.8483	1
Plasmodium falciparum	acyl-CoA synthetase	0.0014	0.0041	0.086
Trichomonas vaginalis	chromobox protein, putative	0.0019	0.0115	0.027
Echinococcus granulosus	Protein patched homolog 1	0.0034	0.0349	0.04
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0018	0.0102	0.0092
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0359	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0349	0.0875
Schistosoma mansoni	hypothetical protein	0.0033	0.033	0.0378
Brugia malayi	hypothetical protein	0.0029	0.027	0.0696
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0116	0.0299
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0035	0.0371	0.2138
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0295
Schistosoma mansoni	hypothetical protein	0.0033	0.033	0.0378
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0034	0.0349	0.0899
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0261	0.3883	1
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0113	0.1576	0.9279
Echinococcus multilocularis	Niemann Pick C1 protein	0.0079	0.1055	0.1046
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0019	0.0115	0.0123
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0229	0.3386	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0029	0.0112
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0019	0.0116	0.063
Echinococcus granulosus	chromobox protein 1	0.0116	0.1627	0.1908
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0157	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0832	0.2143
Echinococcus granulosus	glycogen phosphorylase	0.0261	0.3883	0.4572
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0029	0.027	0.0307
Loa Loa (eye worm)	PHD-finger family protein	0.0017	0.0078	0.02
Giardia lamblia	Glycogen phosphorylase	0.0261	0.3883	1
Echinococcus granulosus	expressed conserved protein	0.0074	0.098	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0116	0.0299
Onchocerca volvulus		0.0022	0.0157	0.0113
Echinococcus multilocularis	protein dispatched 1	0.0039	0.0424	0.0414
Trypanosoma cruzi	ISWI complex protein	0.0012	0.0011	0.0002
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0081	0.1078	0.8725
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0019	0.0115	0.2722
Schistosoma mansoni	chromobox protein	0.0019	0.0115	0.0123
Leishmania major	4-coumarate:coa ligase-like protein	0.0019	0.0116	0.0315
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0014	0.0041	0.0184
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0359	0.0412
Trichomonas vaginalis	hypothetical protein	0.0019	0.0115	0.027
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.004	0.0439	0.1132
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0081	0.1078	0.633
Echinococcus multilocularis	Chromo domain	0.0019	0.0115	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0041	0.0106
Brugia malayi	Thioredoxin reductase	0.0035	0.0371	0.0955
Brugia malayi	Bromodomain containing protein	0.0031	0.0299	0.0771
Entamoeba histolytica	acyl-coA synthetase, putative	0.0019	0.0116	0.0005
Echinococcus multilocularis	zinc finger protein	0.0016	0.0064	0.0054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0359	0.0412
Brugia malayi	MH2 domain containing protein	0.009	0.1229	0.3164
Echinococcus multilocularis	glycogen phosphorylase	0.0261	0.3883	0.3877
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0032	0.032	0.0919
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0116	0.063
Schistosoma mansoni	zinc finger protein	0.0016	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0136	0.1946	0.2285
Schistosoma mansoni	hypothetical protein	0.0136	0.1946	0.2285
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Echinococcus granulosus	tumor protein p63	0.0272	0.4061	0.4781
Onchocerca volvulus		0.0022	0.0157	0.0113
Schistosoma mansoni	bromodomain containing protein	0.0051	0.0613	0.0712
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0108	0.1507	0.4434
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0019	0.0115	0.2897
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Schistosoma mansoni	chromobox protein	0.0116	0.1627	0.1908
Echinococcus multilocularis	expressed conserved protein	0.0074	0.098	0.0971
Schistosoma mansoni	cellular tumor antigen P53	0.004	0.044	0.0507
Echinococcus multilocularis	chromobox protein 2	0.0019	0.0115	0.0105
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0035	0.0359	0.0412
Loa Loa (eye worm)	bromodomain containing protein	0.0014	0.004	0.0104
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0019	0.0115	0.0123
Schistosoma mansoni	glycogen phosphorylase	0.0261	0.3883	0.4572
Echinococcus multilocularis	sterol regulatory element binding protein	0.0034	0.0349	0.0339
Brugia malayi	Protein cec-1.	0.0019	0.0115	0.0295
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.009	0.1219	1
Schistosoma mansoni	hypothetical protein	0.0033	0.033	0.0378
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0108	0.1507	0.4434
Plasmodium falciparum	glutathione reductase	0.0035	0.0371	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0372	0.5625	0.562
Schistosoma mansoni	lamin	0.0022	0.0157	0.0174
Echinococcus granulosus	Chromobox protein 3	0.0019	0.0115	0.0123
Trypanosoma brucei	trypanothione reductase	0.0035	0.0371	0.1069
Echinococcus multilocularis	tumor protein p63	0.0272	0.4061	0.4055
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0536	0.1359
Plasmodium vivax	acyl-CoA synthetase, putative	0.0014	0.0041	0.086
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0014	0.0033	0.0027
Echinococcus granulosus	fetal alzheimer antigen falz	0.0018	0.0102	0.0108
Entamoeba histolytica	hypothetical protein	0.0029	0.027	0.0413
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0019	0.0116	0.063
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0113	0.1576	0.9279
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0019	0.0115	0.0295
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0021	0.0139	0.0129
Echinococcus granulosus	lamin	0.0022	0.0157	0.0174
Brugia malayi	Intermediate filament tail domain containing protein	0.0022	0.0157	0.0405
Echinococcus multilocularis	glycogen phosphorylase	0.0261	0.3883	0.3877
Leishmania major	4-coumarate:coa ligase-like protein	0.0019	0.0116	0.0315
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0014	0.0041	0.008
Loa Loa (eye worm)	MH2 domain-containing protein	0.009	0.1229	0.3164
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Echinococcus granulosus	sterol regulatory element binding protein	0.0034	0.0349	0.04
Plasmodium falciparum	heterochromatin protein 1	0.0019	0.0115	0.2897
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0019	0.0115	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0151	0.0389
Chlamydia trachomatis	glycogen phosphorylase	0.0261	0.3883	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0116	0.063
Brugia malayi	hypothetical protein	0.0019	0.0115	0.0295
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0081	0.1078	0.633
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.2716
Schistosoma mansoni	hypothetical protein	0.0029	0.027	0.0307
Echinococcus multilocularis	chromobox protein 1	0.0116	0.1627	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0033	0.033	0.085
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0229	0.3386	1
Onchocerca volvulus		0.0051	0.0613	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0295
Schistosoma mansoni	glycogen phosphorylase	0.0113	0.1576	0.1848
Loa Loa (eye worm)	hypothetical protein	0.004	0.044	0.1132
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0079	0.1055	0.2495
Leishmania major	hypothetical protein, conserved	0.0012	0.0011	0.0002
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0014	0.0033	0.0027
Echinococcus granulosus	neuropeptide receptor A26	0.0372	0.5625	0.6627
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0295
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0029	0.0112
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0229	0.3386	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0035	0.0359	0.0924
Brugia malayi	Valyl-tRNA synthetase	0.0019	0.0115	0.0295
Echinococcus multilocularis	survival motor neuron protein 1	0.0195	0.2862	0.2855
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0116	0.063
Schistosoma mansoni	hypothetical protein	0.0017	0.0078	0.008
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0035	0.0359	0.0349
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0019	0.0116	0.063
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0048	0.0568	0.0559
Entamoeba histolytica	hypothetical protein	0.0029	0.027	0.0413
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0014	0.0033	0.0027
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0261	0.3883	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0295
Echinococcus multilocularis	Niemann Pick C1 protein	0.0113	0.1585	0.1577
Plasmodium vivax	thioredoxin reductase, putative	0.0035	0.0371	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0019	0.0115	0.0123
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0029	0.0112
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0029	0.027	0.0261
Brugia malayi	Associated with TFs and helicases family protein	0.0019	0.0115	0.0295
Brugia malayi	PHD-finger family protein	0.002	0.0131	0.0338
Onchocerca volvulus		0.0019	0.0116	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0832	0.2123
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0081	0.1078	0.633
Brugia malayi	hypothetical protein	0.0195	0.2862	0.7371
Entamoeba histolytica	glycogenphosphorylase, putative	0.0113	0.1576	0.3878
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0022	0.0157	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0041	0.0106
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0019	0.0116	0.0005
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0261	0.3883	1
Leishmania major	trypanothione reductase	0.0035	0.0371	0.1069
Echinococcus multilocularis	Chromobox protein 3	0.0019	0.0115	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0116	0.063
Schistosoma mansoni	patched 1	0.0034	0.0349	0.04
Echinococcus granulosus	chromobox protein 2	0.0019	0.0115	0.0123
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0116	0.063
Echinococcus granulosus	Glycosyl transferase family 35	0.0261	0.3883	0.4572
Echinococcus granulosus	microtubule associated protein 2	0.0556	0.8483	1
Brugia malayi	CHE-14 protein	0.0034	0.0349	0.0899
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Echinococcus granulosus	neuropeptide s receptor	0.0372	0.5625	0.6627
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0012	0.001	0.0026
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0014	0.0033	0.0027
Brugia malayi	glutathione reductase	0.0035	0.0371	0.0955
Echinococcus multilocularis	lamin dm0	0.0022	0.0157	0.0147
Echinococcus granulosus	geminin	0.0136	0.1946	0.2285
Schistosoma mansoni	chromobox protein	0.0116	0.1627	0.1908
Trichomonas vaginalis	Heterochromatin protein, putative	0.0019	0.0115	0.027
Brugia malayi	carbohydrate phosphorylase	0.0261	0.3883	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0613	0.1579
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0012	0.001	0.5
Schistosoma mansoni	hypothetical protein	0.004	0.0439	0.0507
Schistosoma mansoni	glycogen phosphorylase	0.0261	0.3883	0.4572
Echinococcus multilocularis	chromobox protein 1	0.0116	0.1627	0.1618
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0115	0.027
Brugia malayi	Bromodomain containing protein	0.006	0.076	0.1958
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0021	0.0139	0.0152
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0108	0.1507	0.4434
Brugia malayi	CHD4 protein	0.0021	0.0139	0.0357
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0032	0.032	0.0919
Brugia malayi	chromobox protein homolog 3	0.0065	0.0832	0.2143
Trypanosoma cruzi	ISWI complex protein	0.0012	0.0011	0.0002
Trypanosoma brucei	ISWI complex protein	0.0012	0.0011	0.0002
Plasmodium vivax	glutathione reductase, putative	0.0035	0.0371	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0039	0.043	0.1244
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.007	0.0909	0.2108
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0041	0.0106
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0029	0.027	0.0307
Entamoeba histolytica	hypothetical protein	0.0029	0.027	0.0413
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0013	0.0029	0.0112
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0029	0.027	0.026
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0115	0.027
Echinococcus multilocularis	geminin	0.0136	0.1946	0.1938
Schistosoma mansoni	hypothetical protein	0.0012	0.0011	0.0001
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0018	0.0102	0.0108
Schistosoma mansoni	intermediate filament proteins	0.0022	0.0157	0.0174
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0032	0.032	0.0919
Schistosoma mansoni	transcription factor LCR-F1	0.0029	0.027	0.0307
Trypanosoma cruzi	trypanothione reductase, putative	0.0035	0.0371	0.1069
Brugia malayi	intermediate filament protein	0.0022	0.0157	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0295
Loa Loa (eye worm)	CHromoDomain protein family member	0.0021	0.0139	0.0357
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Treponema pallidum	NADH oxidase	0.0012	0.001	0.5
Echinococcus multilocularis	lamin	0.0022	0.0157	0.0147
Loa Loa (eye worm)	glycogen phosphorylase	0.0261	0.3883	1
Echinococcus multilocularis	protein patched	0.0034	0.0349	0.0339
Echinococcus granulosus	Chromo domain	0.0019	0.0115	0.0123
Loa Loa (eye worm)	thioredoxin reductase	0.0035	0.0371	0.0955
Brugia malayi	Niemann-Pick C1 protein precursor	0.0079	0.1055	0.2716
Loa Loa (eye worm)	glutathione reductase	0.0035	0.0371	0.0955
Entamoeba histolytica	glycogen phosphorylase, putative	0.0261	0.3883	1
Brugia malayi	M-phase phosphoprotein, mpp8	0.0019	0.0115	0.0295
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0035	0.0359	0.0349
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Entamoeba histolytica	glycogen phosphorylase, putative	0.0261	0.3883	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0065	0.0832	0.1904
Entamoeba histolytica	glycogen phosphorylase, putative	0.0113	0.1576	0.3878
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0036	0.0378	0.0369
Echinococcus granulosus	chromobox protein 1	0.0116	0.1627	0.1908
Echinococcus granulosus	histone lysine methyltransferase setb	0.0014	0.0033	0.0027
Echinococcus granulosus	glycogen phosphorylase	0.0261	0.3883	0.4572
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0012	0.001	0.5
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0019	0.0115	0.2897
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0032	0.032	0.0919
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Schistosoma mansoni	hypothetical protein	0.0033	0.033	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0354	0.0912
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0909	0.2321
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.009	0.1219	0.7163
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0116	0.0299
Schistosoma mansoni	zinc finger protein	0.0012	0.0011	0.0001
Echinococcus granulosus	survival motor neuron protein 1	0.0195	0.2862	0.3366
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0019	0.0116	0.0005
Echinococcus multilocularis	neuropeptide s receptor	0.0372	0.5625	0.562
Loa Loa (eye worm)	hypothetical protein	0.0031	0.03	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0468	0.1206
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0014	0.0033	0.0023
Onchocerca volvulus		0.004	0.044	0.0862
Toxoplasma gondii	hypothetical protein	0.0037	0.0394	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0081	0.1074	0.1256
Loa Loa (eye worm)	helicase	0.0019	0.0115	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0349	0.0899
Loa Loa (eye worm)	heterochromatin protein 1	0.0116	0.1627	0.4189
Trichomonas vaginalis	chromobox protein, putative	0.0116	0.1627	0.4174
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0115	0.027
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0041	0.0106
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0115	0.027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0295
Plasmodium vivax	heterochromatin protein 1, putative	0.0019	0.0115	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0295
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0014	0.0033	0.0027
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0115	0.027
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0019	0.0115	0.0105
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0116	0.0299

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 1.06 uM	In vitro inhibition of glucagon-stimulated glycogenolysis in primary rat hepatocytes	ChEMBL.	14505637
IC50 (binding)	= 13 nM	In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)	ChEMBL.	14505637
IC50 (binding)	= 13 nM	In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)	ChEMBL.	14505637
IC50 (binding)	= 41 nM	In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa)	ChEMBL.	14505637
IC50 (binding)	= 41 nM	In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa)	ChEMBL.	14505637

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL334272

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 188313