Detailed information for compound 1885053

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.888 | Formula: C23H19ClN6O3
  • H donors: 1 H acceptors: 5 LogP: 3.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\C(=C\1/NCCN1Cc1ccc(nc1)Cl)\[N+](=O)[O-])/C(=O)c1cn(c2c1cccc2)C
  • InChi: 1S/C23H19ClN6O3/c1-28-14-18(17-4-2-3-5-19(17)28)22(31)16(11-25)10-20(30(32)33)23-26-8-9-29(23)13-15-6-7-21(24)27-12-15/h2-7,10,12,14,26H,8-9,13H2,1H3/b16-10+,23-20-
  • InChiKey: YICWHKDIQJOFBH-XFNLHSONSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.0312 0.067
Brugia malayi calpain 7 0.032 0.0437 0.0437
Entamoeba histolytica cysteine proteinase, putative 0.1246 0.2412 0.4936
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0431 0.0673 0.0672
Echinococcus granulosus calpain A 0.032 0.0437 0.0436
Plasmodium falciparum serine repeat antigen 8 0.0531 0.0887 0.1898
Loa Loa (eye worm) hypothetical protein 0.0148 0.007 0.007
Echinococcus granulosus Mastin 0.0342 0.0483 0.0482
Giardia lamblia Cathepsin L precursor 0.0531 0.0887 0.2393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1246 0.2412 0.5188
Brugia malayi Trypsin family protein 0.1498 0.295 0.295
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0915 0.1705 0.2291
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.0514
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0351 0.0502 0.0501
Onchocerca volvulus 0.2295 0.4649 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0118 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Mycobacterium tuberculosis Possible exported protein 0.0385 0.0574 0.5033
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0229 0.0242 0.0242
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Echinococcus multilocularis cysteine protease 0.2295 0.4649 0.4648
Brugia malayi Trypsin family protein 0.0342 0.0483 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Trypanosoma cruzi cruzipain precursor, putative 0.0715 0.1279 0.1218
Plasmodium falciparum serine repeat antigen 9 0.0531 0.0887 0.1898
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.0514
Echinococcus granulosus transmembrane protease serine 3 0.0342 0.0483 0.0482
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0849 0.1565 0.1564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1246 0.2412 0.3281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Giardia lamblia Cysteine protease 0.0531 0.0887 0.2393
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.065 0.114 0.114
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2295 0.4649 1
Brugia malayi Cathepsin L-like precursor 0.0715 0.1279 0.1279
Entamoeba histolytica cysteine proteinase, putative 0.2295 0.4649 1
Schistosoma mansoni dopamine-beta-monooxygenase 0.0229 0.0242 0.0241
Echinococcus multilocularis cathepsin L cysteine protease 0.2295 0.4649 0.4648
Giardia lamblia Cathepsin L precursor 0.0531 0.0887 0.2393
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.0312 0.067
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0531 0.0887 0.1898
Onchocerca volvulus 0.2295 0.4649 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0915 0.1705 0.2291
Echinococcus multilocularis calpain 7 (C02 family) 0.032 0.0437 0.0436
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0628 0.1094 0.1094
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0479 0.0776 0.0776
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0531 0.0887 0.1898
Brugia malayi Cathepsin L-like precursor 0.158 0.3124 0.3124
Echinococcus multilocularis prolyl endopeptidase 0.0148 0.007 0.0069
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0342 0.0483 0.0482
Onchocerca volvulus Cathepsin F homolog 0.2295 0.4649 1
Toxoplasma gondii kringle domain-containing protein 0.0615 0.1066 0.2284
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0531 0.0887 0.1907
Onchocerca volvulus 0.2295 0.4649 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0531 0.0887 0.1484
Brugia malayi Cathepsin L-like precursor 0.2295 0.4649 0.4649
Schistosoma mansoni Mername-AA248 (C02 family) 0.032 0.0437 0.0436
Plasmodium vivax vivapain-2 0.2295 0.4649 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0118 0.0005 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Entamoeba histolytica cysteine protease, putative 0.0531 0.0887 0.1484
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.0312 0.067
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0915 0.1705 0.3661
Trypanosoma cruzi metacaspase, putative 0.0262 0.0312 0.0244
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1853 0.3705 0.3661
Brugia malayi Cathepsin L-like precursor 0.2295 0.4649 0.4649
Loa Loa (eye worm) hypothetical protein 0.0342 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0715 0.1279 0.1279
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.032 0.0437 0.037
Trypanosoma cruzi cysteine proteinase, putative 0.1246 0.2412 0.2359
Brugia malayi hypothetical protein 0.0309 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0531 0.0887 0.1907
Onchocerca volvulus 0.0529 0.0881 0.1895
Entamoeba histolytica cysteine protease, putative 0.0531 0.0887 0.1484
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2295 0.4649 1
Schistosoma mansoni cathepsin D (A01 family) 0.1452 0.2851 0.2851
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0531 0.0887 0.1898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.0887 0.1907
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0262 0.0312 0.066
Plasmodium vivax aspartyl proteinase, putative 0.0479 0.0776 0.1659
Echinococcus multilocularis dihydrofolate reductase 0.0265 0.0319 0.0319
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0262 0.0312 0.0312
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4804 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.2295 0.4649 0.4648
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0179 0.0136 0.0135
Trypanosoma cruzi cruzipain precursor, putative 0.3495 0.7209 0.7189
Trypanosoma brucei metacaspase MCA2 0.0262 0.0312 0.0339
Giardia lamblia Cysteine protease 0.0531 0.0887 0.2393
Plasmodium falciparum cysteine repeat modular protein 1 0.0615 0.1066 0.2284
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Echinococcus multilocularis cathepsin L 0.1246 0.2412 0.2412
Trypanosoma brucei metacaspase 0.0262 0.0312 0.0339
Plasmodium vivax unspecified product 0.1246 0.2412 0.5183
Brugia malayi Cathepsin L-like precursor 0.2295 0.4649 0.4649
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0531 0.0887 0.0886
Onchocerca volvulus 0.2295 0.4649 1
Onchocerca volvulus 0.065 0.114 0.2452
Onchocerca volvulus Prolyl endopeptidase homolog 0.0148 0.007 0.0149
Plasmodium vivax aspartyl protease, putative 0.0162 0.0099 0.0201
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0326 0.045 0.045
Schistosoma mansoni growth factor receptor-bound protein 0.0326 0.045 0.045
Leishmania major cathepsin L-like protease 0.2295 0.4649 0.6414
Trypanosoma brucei calpain-like protein, putative 0.032 0.0437 0.0514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0531 0.0887 0.0887
Schistosoma mansoni memapsin-2 (A01 family) 0.0118 0.0005 0.0005
Brugia malayi Trypsin family protein 0.0342 0.0483 0.0483
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0894 0.166 0.1659
Echinococcus granulosus tissue type plasminogen activator 0.0615 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0715 0.1279 0.1279
Trypanosoma cruzi cysteine peptidase, putative 0.3495 0.7209 0.7189
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0531 0.0887 0.1898
Echinococcus granulosus cysteine protease 0.1246 0.2412 0.2412
Echinococcus multilocularis Tolloid protein 1 0.0179 0.0136 0.0135
Loa Loa (eye worm) hypothetical protein 0.0229 0.0242 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1246 0.2412 0.3281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Trypanosoma cruzi hypothetical protein, conserved 0.0615 0.1066 0.1003
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0531 0.0887 0.1898
Echinococcus multilocularis cathepsin L 0.0531 0.0887 0.0886
Loa Loa (eye worm) hypothetical protein 0.0625 0.1087 0.1087
Onchocerca volvulus 0.2295 0.4649 1
Onchocerca volvulus Cathepsin L homolog 0.2295 0.4649 1
Trypanosoma cruzi metacaspase, putative 0.0262 0.0312 0.0244
Onchocerca volvulus 0.1498 0.295 0.6345
Loa Loa (eye worm) STAT protein 0.035 0.0501 0.0501
Schistosoma mansoni calpain-7 (C02 family) 0.032 0.0437 0.0436
Brugia malayi Papain family cysteine protease containing protein 0.2295 0.4649 0.4649
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.0312 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Echinococcus granulosus thymidylate synthase 0.065 0.114 0.114
Onchocerca volvulus Cathepsin L homolog 0.2295 0.4649 1
Trypanosoma cruzi cysteine peptidase, putative 0.3495 0.7209 0.7189
Onchocerca volvulus 0.0342 0.0483 0.1037
Trypanosoma brucei Metacaspase-4 0.0262 0.0312 0.0339
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Echinococcus granulosus cathepsin b 0.4804 1 1
Giardia lamblia Cathepsin L precursor 0.0531 0.0887 0.2393
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2295 0.4649 0.4648
Onchocerca volvulus 0.2295 0.4649 1
Loa Loa (eye worm) dihydrofolate reductase 0.0265 0.0319 0.0319
Loa Loa (eye worm) thymidylate synthase 0.065 0.114 0.114
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Loa Loa (eye worm) fibroinase 0.2295 0.4649 0.4649
Giardia lamblia Cathepsin L precursor 0.0531 0.0887 0.2393
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1246 0.2412 0.2412
Brugia malayi Cathepsin L-like precursor 0.2295 0.4649 0.4649
Leishmania major cathepsin L-like protease 0.2295 0.4649 0.6414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Entamoeba histolytica cysteine proteinase, putative 0.1246 0.2412 0.4936
Trypanosoma cruzi metacaspase, putative 0.0262 0.0312 0.0244
Echinococcus multilocularis thymidylate synthase 0.065 0.114 0.114
Echinococcus multilocularis cysteine protease 0.2295 0.4649 0.4648
Loa Loa (eye worm) hypothetical protein 0.158 0.3124 0.3124
Echinococcus multilocularis caspase 2 0.0473 0.0763 0.0762
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Toxoplasma gondii prolyl endopeptidase 0.0148 0.007 0.0138
Schistosoma mansoni peptidylglycine monooxygenase 0.0229 0.0242 0.0241
Loa Loa (eye worm) hypothetical protein 0.4804 1 1
Plasmodium falciparum serine repeat antigen 4 0.0531 0.0887 0.1898
Schistosoma mansoni cathepsin D (A01 family) 0.1452 0.2851 0.2851
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0531 0.0887 0.1907
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Plasmodium falciparum serine repeat antigen 5 0.0531 0.0887 0.1898
Plasmodium vivax calpain, putative 0.032 0.0437 0.0929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0915 0.1705 0.3661
Entamoeba histolytica cysteine proteinase, putative 0.158 0.3124 0.6547
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0531 0.0887 0.2393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.158 0.3124 0.6719
Mycobacterium ulcerans thymidylate synthase 0.065 0.114 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Schistosoma mansoni growth factor receptor-bound protein 0.0326 0.045 0.045
Brugia malayi cathepsin F-like cysteine proteinase 0.0715 0.1279 0.1279
Leishmania major cathepsin L-like protease 0.3495 0.7209 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.0887 0.1907
Onchocerca volvulus 0.2295 0.4649 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0342 0.0483 0.0482
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.032 0.0437 0.0514
Brugia malayi cathepsin L-like cysteine proteinase 0.0531 0.0887 0.0887
Loa Loa (eye worm) hypothetical protein 0.0175 0.0127 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Giardia lamblia Cathepsin L precursor 0.0531 0.0887 0.2393
Trypanosoma cruzi cysteine proteinase, putative 0.1246 0.2412 0.2359
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0262 0.0312 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1246 0.2412 0.5188
Schistosoma mansoni hypothetical protein 0.0342 0.0483 0.0482
Echinococcus granulosus cathepsin L cysteine proteinase 0.2295 0.4649 0.4648
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.032 0.0437 0.037
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0915 0.1705 0.1647
Schistosoma mansoni dihydrofolate reductase 0.0265 0.0319 0.0319
Plasmodium falciparum serine repeat antigen 2 0.0531 0.0887 0.1898
Plasmodium falciparum serine repeat antigen 7 0.0531 0.0887 0.1898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1507 0.2969 0.2969
Plasmodium vivax unspecified product 0.0715 0.1279 0.2742
Onchocerca volvulus 0.0342 0.0483 0.1037
Echinococcus granulosus cathepsin l1 0.158 0.3124 0.3123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Loa Loa (eye worm) hypothetical protein 0.0715 0.1279 0.1279
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.037
Loa Loa (eye worm) TK/ROR protein kinase 0.0615 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0342 0.0483 0.0483
Echinococcus granulosus caspase 3 0.0367 0.0536 0.0535
Echinococcus granulosus cathepsin l1 0.2295 0.4649 0.4648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0342 0.0483 0.0482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0342 0.0483 0.0482
Schistosoma mansoni calpain-7 (C02 family) 0.032 0.0437 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2295 0.4649 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0531 0.0887 0.0887
Loa Loa (eye worm) hypothetical protein 0.2295 0.4649 0.4649
Loa Loa (eye worm) calpain family protein 1 0.0849 0.1565 0.1565
Brugia malayi cathepsin L-like precursor 0.158 0.3124 0.3124
Schistosoma mansoni caspase-7 (C14 family) 0.0628 0.1094 0.1094
Echinococcus granulosus calpain 5 0.032 0.0437 0.0436
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.032 0.0437 0.037
Plasmodium falciparum plasmepsin IV 0.0479 0.0776 0.1659
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Echinococcus granulosus caspase 2 0.0473 0.0763 0.0762
Schistosoma mansoni cathepsin C 0.0531 0.0887 0.0886
Giardia lamblia Hypothetical protein 0.0531 0.0887 0.2393
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.0887 0.1907
Trypanosoma brucei metacaspase MCA3 0.0262 0.0312 0.0339
Plasmodium falciparum plasmepsin I 0.0479 0.0776 0.1659
Echinococcus multilocularis cathepsin b 0.4804 1 1
Leishmania major cathepsin L-like protease 0.2295 0.4649 0.6414
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0342 0.0483 0.0482
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.0887 0.1907
Plasmodium falciparum serine repeat antigen 6 0.0531 0.0887 0.1898
Leishmania major metacaspase, putative 0.0262 0.0312 0.0339
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0431 0.0673 0.0672
Loa Loa (eye worm) hypothetical protein 0.0849 0.1565 0.1565
Trypanosoma cruzi metacaspase, putative 0.0262 0.0312 0.0244
Trypanosoma brucei metacaspase 5, putative 0.0262 0.0312 0.0339
Loa Loa (eye worm) cysteine protease 0.2295 0.4649 0.4649
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Brugia malayi Papain family cysteine protease containing protein 0.0531 0.0887 0.0887
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1853 0.3705 0.3705
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0531 0.0887 0.1898
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0463 0.074 0.074
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0715 0.1279 0.1279
Onchocerca volvulus 0.0342 0.0483 0.1037
Brugia malayi Trypsin family protein 0.0342 0.0483 0.0483
Schistosoma mansoni cathepsin F (C01 family) 0.2295 0.4649 0.4648
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0715 0.1279 0.1279
Trypanosoma brucei calpain-like protein, putative 0.032 0.0437 0.0514
Giardia lamblia Cathepsin L-like protease 0.0531 0.0887 0.2393
Loa Loa (eye worm) calpain 5 0.0224 0.0231 0.0231
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0531 0.0887 0.1898
Trypanosoma cruzi cysteine peptidase, putative 0.1246 0.2412 0.2359
Loa Loa (eye worm) hypothetical protein 0.0431 0.0673 0.0673
Echinococcus granulosus Tolloid protein 1 0.0179 0.0136 0.0135
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Brugia malayi dihydrofolate reductase family protein 0.0265 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.0342 0.0483 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Trypanosoma cruzi major cysteine proteinase, putative 0.1732 0.3447 0.3401
Loa Loa (eye worm) hypothetical protein 0.0531 0.0887 0.0887
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.158 0.3124 0.6719
Giardia lamblia Cathepsin B precursor 0.0531 0.0887 0.2393
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.037
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0894 0.166 0.1659
Plasmodium vivax vivapain-1 0.1246 0.2412 0.5183
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0431 0.0673 0.0672
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0715 0.1279 0.1218
Echinococcus multilocularis Mastin 0.0342 0.0483 0.0482
Onchocerca volvulus 0.0211 0.0205 0.0439
Schistosoma mansoni cathepsin F (C01 family) 0.2295 0.4649 0.4648
Toxoplasma gondii cathepsin CPL 0.2295 0.4649 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.3495 0.7209 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0479 0.0776 0.1659
Loa Loa (eye worm) trypsin family protein 0.0342 0.0483 0.0483
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Schistosoma mansoni cathepsin B (C01 family) 0.0531 0.0887 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.0887 0.1907
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1246 0.2412 0.2412
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0531 0.0887 0.1898
Echinococcus multilocularis transmembrane protease serine 3 0.0342 0.0483 0.0482
Loa Loa (eye worm) hypothetical protein 0.0342 0.0483 0.0483
Plasmodium falciparum plasmepsin II 0.0479 0.0776 0.1659
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0531 0.0887 0.2393
Echinococcus granulosus cathepsin L cysteine protease 0.1246 0.2412 0.2412
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0531 0.0887 0.1907
Entamoeba histolytica cysteine proteinase 1, putative 0.1246 0.2412 0.4936
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0531 0.0887 0.1907
Onchocerca volvulus 0.0342 0.0483 0.1037
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0309 0.0413 0.0346
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Brugia malayi Papain family cysteine protease containing protein 0.1246 0.2412 0.2412
Loa Loa (eye worm) hypothetical protein 0.0211 0.0205 0.0205
Entamoeba histolytica cysteine protease, putative 0.0531 0.0887 0.1484
Loa Loa (eye worm) hypothetical protein 0.0118 0.0005 0.0005
Toxoplasma gondii cathepsin CPC2 0.0531 0.0887 0.1898
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4804 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0531 0.0887 0.1907
Trypanosoma cruzi metacaspase 5, putative 0.0262 0.0312 0.0244
Echinococcus granulosus cathepsin b 0.4804 1 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0628 0.1094 0.1094
Schistosoma mansoni caspase-3 (C14 family) 0.0628 0.1094 0.1094
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0531 0.0887 0.0886
Mycobacterium tuberculosis Hypothetical protein 0.0309 0.0413 0.3622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Echinococcus multilocularis caspase 8 0.0262 0.0312 0.0311
Brugia malayi Cathepsin L-like cysteine proteinase 0.158 0.3124 0.3124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Brugia malayi Pepsin A precursor 0.0118 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Brugia malayi Cathepsin L-like precursor 0.2295 0.4649 0.4649
Plasmodium vivax vivapain-2 0.2295 0.4649 1
Leishmania major cathepsin L-like protease 0.2295 0.4649 0.6414
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2295 0.4649 0.4649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0531 0.0887 0.1907
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Echinococcus multilocularis calpain A 0.0894 0.1661 0.166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Brugia malayi Papain family cysteine protease containing protein 0.0531 0.0887 0.0887
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0531 0.0887 0.0886
Giardia lamblia Cysteine protease 0.0531 0.0887 0.2393
Trypanosoma cruzi kinesin, putative 0.0224 0.0231 0.0163
Giardia lamblia Cysteine protease 0.0531 0.0887 0.2393
Loa Loa (eye worm) hypothetical protein 0.0531 0.0887 0.0887
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.065 0.114 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0211 0.0205 0.0204
Brugia malayi prolyl oligopeptidase family protein 0.0148 0.007 0.007
Onchocerca volvulus 0.0342 0.0483 0.1037
Loa Loa (eye worm) hypothetical protein 0.158 0.3124 0.3124
Trypanosoma brucei calpain-like protein, putative 0.032 0.0437 0.0514
Plasmodium falciparum metacaspase 1 0.0262 0.0312 0.066
Brugia malayi hypothetical protein 0.0342 0.0483 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1853 0.3705 0.7971
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Trypanosoma cruzi cysteine peptidase, putative 0.3495 0.7209 0.7189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.032 0.0437 0.037
Loa Loa (eye worm) hypothetical protein 0.1498 0.295 0.295
Onchocerca volvulus 0.158 0.3124 0.6719
Echinococcus granulosus caspase 0.0628 0.1094 0.1094
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0342 0.0483 0.0482
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0479 0.0776 0.0776
Entamoeba histolytica hypothetical protein 0.0531 0.0887 0.1484
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0133 0.0036 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.0887 0.1907
Echinococcus multilocularis caspase 0.0628 0.1094 0.1094
Loa Loa (eye worm) calpain family protein 1 0.0625 0.1087 0.1087
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Leishmania major cysteine peptidase A (CPA) 0.2295 0.4649 0.6414
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0531 0.0887 0.1898
Onchocerca volvulus 0.0531 0.0887 0.1907
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Plasmodium vivax hypothetical protein, conserved 0.0262 0.0312 0.066
Loa Loa (eye worm) hypothetical protein 0.0342 0.0483 0.0483
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4804 1 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0118 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1246 0.2412 0.2359
Echinococcus granulosus calpain A 0.0894 0.1661 0.166
Onchocerca volvulus Cathepsin L homolog 0.0531 0.0887 0.1907
Echinococcus multilocularis calpain family protein 1, d 0.0625 0.1087 0.1086
Onchocerca volvulus 0.1157 0.2221 0.4777
Brugia malayi Protein kinase domain containing protein 0.0615 0.1066 0.1066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0531 0.0887 0.0886
Brugia malayi Angiotensin-converting enzyme family protein 0.0463 0.074 0.074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2295 0.4649 0.4648
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1246 0.2412 0.2412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0531 0.0887 0.1907
Loa Loa (eye worm) hypothetical protein 0.158 0.3124 0.3124
Loa Loa (eye worm) hypothetical protein 0.0531 0.0887 0.0887
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4804 1 1
Onchocerca volvulus 0.0615 0.1066 0.2292
Loa Loa (eye worm) hypothetical protein 0.1498 0.295 0.295
Echinococcus granulosus enteropeptidase 0.0342 0.0483 0.0482
Plasmodium vivax aspartyl protease, putative 0.0162 0.0099 0.0201
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0531 0.0887 0.1898
Brugia malayi Trypsin-like protease protein 5 0.0342 0.0483 0.0483
Brugia malayi hypothetical protein 0.0211 0.0205 0.0205
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.278 0.5684 0.5653
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Trypanosoma cruzi major cysteine proteinase, putative 0.0531 0.0887 0.0823
Echinococcus multilocularis caspase 3 0.0367 0.0536 0.0535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4804 1 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0531 0.0887 0.1898
Loa Loa (eye worm) hypothetical protein 0.0529 0.0881 0.0881
Echinococcus multilocularis cathepsin L cysteine protease 0.2295 0.4649 0.4648
Echinococcus granulosus dihydrofolate reductase 0.0265 0.0319 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.0887 0.1907
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0615 0.1066 0.2284
Loa Loa (eye worm) hypothetical protein 0.0479 0.0776 0.0776
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2295 0.4649 0.4649
Schistosoma mansoni caspase-7 (C14 family) 0.0473 0.0763 0.0762
Loa Loa (eye worm) calpain 0.032 0.0437 0.0437
Giardia lamblia Cathepsin B precursor 0.0531 0.0887 0.2393
Mycobacterium ulcerans hypothetical protein 0.0342 0.0483 0.4231
Brugia malayi Cell death protein 3 precursor 0.0473 0.0763 0.0763
Giardia lamblia Cathepsin B precursor 0.1853 0.3705 1
Trypanosoma cruzi cysteine protease, putative 0.1246 0.2412 0.2359
Brugia malayi Kringle domain containing protein 0.0615 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0531 0.0887 0.0887
Echinococcus granulosus caspase 8 0.0262 0.0312 0.0311
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.065 0.114 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0479 0.0776 0.0776
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0531 0.0887 0.1898
Giardia lamblia Cathepsin B precursor 0.1853 0.3705 1
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.0887 0.1907
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Giardia lamblia Cathepsin B precursor 0.0531 0.0887 0.2393
Schistosoma mansoni calpain C (C02 family) 0.032 0.0437 0.0436
Leishmania major kinesin, putative 0.0224 0.0231 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Brugia malayi Papain family cysteine protease containing protein 0.1246 0.2412 0.2412
Echinococcus granulosus cathepsin L 0.0531 0.0887 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.0312 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2295 0.4649 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.037
Echinococcus granulosus prolyl endopeptidase 0.0148 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0615 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0531 0.0887 0.0887
Entamoeba histolytica cysteine protease, putative 0.0531 0.0887 0.1484
Giardia lamblia Encystation-specific protease 0.0531 0.0887 0.2393
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1853 0.3705 0.5093
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.037
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0265 0.0319 0.2796
Entamoeba histolytica cysteine proteinase, putative 0.1246 0.2412 0.4936
Brugia malayi calpain 5 0.0224 0.0231 0.0231
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Echinococcus multilocularis cathepsin b 0.4804 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0342 0.0483 0.0482
Brugia malayi STAT protein, DNA binding domain containing protein 0.035 0.0501 0.0501
Loa Loa (eye worm) cathepsin B 0.1853 0.3705 0.3705
Plasmodium vivax serine-repeat antigen (SERA) 0.0531 0.0887 0.1898
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0148 0.007 0.0069
Brugia malayi Cathepsin L-like precursor 0.2295 0.4649 0.4649
Plasmodium falciparum cysteine proteinase falcipain 3 0.2295 0.4649 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Brugia malayi Sex muscle abnormal protein 5 0.0326 0.045 0.045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0531 0.0887 0.0887
Trypanosoma cruzi kinesin, putative 0.0224 0.0231 0.0163
Entamoeba histolytica cysteine protease, putative 0.0531 0.0887 0.1484
Brugia malayi calpain family protein 1 0.0849 0.1565 0.1565
Entamoeba histolytica cysteine proteinase, putative 0.1246 0.2412 0.4936
Schistosoma mansoni hypothetical protein 0.0615 0.1066 0.1066
Trypanosoma brucei antigen, putative 0.032 0.0437 0.0514
Chlamydia trachomatis dihydrofolate reductase 0.0265 0.0319 0.5
Toxoplasma gondii cathepsin CPC1 0.0531 0.0887 0.1898
Trypanosoma brucei cysteine peptidase C (CPC) 0.1853 0.3705 0.5093
Trypanosoma cruzi calpain cysteine peptidase, putative 0.032 0.0437 0.037
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0531 0.0887 0.0886
Brugia malayi hypothetical protein 0.0118 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.032 0.0437 0.037
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0894 0.166 0.1659
Plasmodium falciparum metacaspase-like protein 0.0262 0.0312 0.066
Entamoeba histolytica cysteine protease, putative 0.2295 0.4649 1
Brugia malayi Dihydrofolate reductase 0.0265 0.0319 0.0319
Plasmodium vivax metacaspase 1, putative 0.0262 0.0312 0.066
Brugia malayi Papain family cysteine protease containing protein 0.0531 0.0887 0.0887
Leishmania major cathepsin L-like protease 0.2295 0.4649 0.6414
Giardia lamblia Cathepsin L-like protease 0.0531 0.0887 0.2393
Brugia malayi Cathepsin L-like precursor 0.158 0.3124 0.3124
Entamoeba histolytica cysteine proteinase 2 0.1246 0.2412 0.4936
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0479 0.0776 0.0776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Toxoplasma gondii aspartyl protease ASP3 0.0162 0.0099 0.0201
Echinococcus multilocularis calpain 5 0.032 0.0437 0.0436
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0531 0.0887 0.2393
Plasmodium vivax serine-repeat antigen (SERA) 0.0531 0.0887 0.1898
Echinococcus multilocularis growth factor receptor bound protein 2 0.0326 0.045 0.045
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.0514
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0265 0.0319 0.2796
Echinococcus multilocularis hypothetical protein 0.032 0.0437 0.0436
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0265 0.0319 0.2796
Brugia malayi cathepsin Z-like cysteine proteinase 0.0531 0.0887 0.0887
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0116 0.0001 0.0001
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0479 0.0776 0.1668
Brugia malayi hypothetical protein 0.0118 0.0005 0.0005
Echinococcus multilocularis enteropeptidase 0.0342 0.0483 0.0482
Onchocerca volvulus 0.0118 0.0005 0.0011
Giardia lamblia Cathepsin B precursor 0.0531 0.0887 0.2393
Plasmodium vivax unspecified product 0.0531 0.0887 0.1898
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0531 0.0887 0.1907
Onchocerca volvulus 0.0118 0.0005 0.0011
Schistosoma mansoni cathepsin S (C01 family) 0.0531 0.0887 0.0886
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0262 0.0312 0.0311
Echinococcus granulosus calpain 7 C02 family 0.032 0.0437 0.0436
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Giardia lamblia Hypothetical protein 0.0531 0.0887 0.2393
Brugia malayi fibroinase precursor 0.0531 0.0887 0.0887
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0531 0.0887 0.0886
Echinococcus multilocularis apoptotic protease activating factor 1 0.0211 0.0205 0.0204
Echinococcus multilocularis tissue type plasminogen activator 0.0615 0.1066 0.1066
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Trypanosoma brucei kinesin, putative 0.0224 0.0231 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Plasmodium falciparum serine repeat antigen 1 0.0531 0.0887 0.1898
Brugia malayi calpain family protein 1 0.0849 0.1565 0.1565
Loa Loa (eye worm) aspartyl protease 6 0.0118 0.0005 0.0005
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0894 0.166 0.1659
Loa Loa (eye worm) hypothetical protein 0.0116 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0179 0.0136 0.0136
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0531 0.0887 0.0886
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0262 0.0312 0.066
Plasmodium falciparum plasmepsin X 0.0162 0.0099 0.0201
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0531 0.0887 0.0886
Brugia malayi cathepsin L precursor 0.0531 0.0887 0.0887
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Schistosoma mansoni cercarial elastase (S01 family) 0.0342 0.0483 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2295 0.4649 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0342 0.0483 0.0482
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Trypanosoma cruzi metacaspase 5, putative 0.0262 0.0312 0.0244
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0531 0.0887 0.0887
Giardia lamblia Cathepsin B precursor 0.0531 0.0887 0.2393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0531 0.0887 0.1907
Entamoeba histolytica cysteine protease, putative 0.0531 0.0887 0.1484
Schistosoma mansoni calpain (C02 family) 0.032 0.0437 0.0436
Toxoplasma gondii aspartyl protease ASP1 0.0479 0.0776 0.1659
Schistosoma mansoni cathepsin s 0.0715 0.1279 0.1278
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0342 0.0483 0.0483
Plasmodium falciparum plasmepsin IX 0.0162 0.0099 0.0201
Giardia lamblia Cathepsin B precursor 0.1853 0.3705 1
Echinococcus multilocularis calpain 0.032 0.0437 0.0436
Loa Loa (eye worm) hypothetical protein 0.0531 0.0887 0.0887
Echinococcus multilocularis glycoprotein Antigen 5 0.0342 0.0483 0.0482
Loa Loa (eye worm) ctsf protein 0.2295 0.4649 0.4649
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0531 0.0887 0.1484
Toxoplasma gondii preprocathepsin c precursor, putative 0.0531 0.0887 0.1898
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.032 0.0437 0.0514
Plasmodium falciparum serine repeat antigen 3 0.0531 0.0887 0.1898
Echinococcus granulosus calpain 0.032 0.0437 0.0436
Trypanosoma brucei calpain-like protein, putative 0.032 0.0437 0.0514
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1498 0.295 0.295
Leishmania major hypothetical protein, conserved 0.0615 0.1066 0.1396
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0262 0.0312 0.067
Entamoeba histolytica cysteine protease, putative 0.1246 0.2412 0.4936
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0531 0.0887 0.1898
Plasmodium falciparum cysteine proteinase falcipain 1 0.1246 0.2412 0.5183
Plasmodium vivax vivapain-3 0.1246 0.2412 0.5183
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0531 0.0887 0.2393
Loa Loa (eye worm) hypothetical protein 0.0753 0.1359 0.1359
Echinococcus granulosus glycoprotein Antigen 5 0.0342 0.0483 0.0482
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0915 0.1705 0.3661
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.0312 0.067
Loa Loa (eye worm) hypothetical protein 0.0342 0.0483 0.0483
Onchocerca volvulus Cell death protein 3 homolog 0.0473 0.0763 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0309 0.0413 0.0888
Loa Loa (eye worm) hypothetical protein 0.0473 0.0763 0.0763
Loa Loa (eye worm) hypothetical protein 0.0262 0.0312 0.0312
Echinococcus granulosus cathepsin L 0.1246 0.2412 0.2412
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0431 0.0673 0.0673
Entamoeba histolytica cysteine proteinase, putative 0.2295 0.4649 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0148 0.007 0.0069
Plasmodium vivax plasmepsin IV, putative 0.0479 0.0776 0.1659
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0531 0.0887 0.0887
Schistosoma mansoni hypothetical protein 0.0211 0.0205 0.0204
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.0005 0.0005
Plasmodium falciparum plasmepsin VI 0.0479 0.0776 0.1659
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0342 0.0483 0.0482
Toxoplasma gondii cathepsin B 0.1853 0.3705 0.7968
Brugia malayi aspartic protease BmAsp-2, identical 0.0118 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.2295 0.4649 0.4611
Giardia lamblia Cathepsin L precursor 0.0531 0.0887 0.2393
Schistosoma mansoni cathepsin F (C01 family) 0.158 0.3124 0.3123
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0531 0.0887 0.1907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3495 0.7209 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2295 0.4649 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0326 0.045 0.045
Brugia malayi thymidylate synthase 0.065 0.114 0.114
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0531 0.0887 0.0887
Leishmania major cathepsin L-like protease 0.3495 0.7209 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0531 0.0887 0.0886

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 75.71 % Cytotoxicity against human HepG2 cells assessed as growth inhibition at 40 ug/ml by MTT assay ChEMBL. 24684840
IC50 (functional) = 15.79 uM Cytotoxicity against human HepG2 cells assessed as growth inhibition by MTT assay ChEMBL. 24684840

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 24684840

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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