Detailed information for compound 1888398

Basic information

Technical information
  • TDR Targets ID: 1888398
  • Name: N-[(4-methoxyphenyl)methylideneamino]-4-(2,2, 3,3-tetrafluoropropoxymethyl)benzamide
  • MW: 398.351 | Formula: C19H18F4N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.98 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=N/NC(=O)c1ccc(cc1)COCC(C(F)F)(F)F
  • InChi: 1S/C19H18F4N2O3/c1-27-16-8-4-13(5-9-16)10-24-25-17(26)15-6-2-14(3-7-15)11-28-12-19(22,23)18(20)21/h2-10,18H,11-12H2,1H3,(H,25,26)/b24-10+
  • InChiKey: FOPWLTXRPLTGAU-YSURURNPSA-N  


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Synonyms

  • N-[(4-methoxyphenyl)methyleneamino]-4-(2,2,3,3-tetrafluoropropoxymethyl)benzamide
  • N-[(4-methoxybenzylidene)amino]-4-(2,2,3,3-tetrafluoropropoxymethyl)benzamide
  • MLS000698206
  • N'-(4-methoxybenzylidene)-4-[(2,2,3,3-tetrafluoropropoxy)methyl]benzohydrazide
  • SMR000227968
  • STK298552
  • AK-968/41026723

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0106 0.0514 0.0418
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0514 0.1236
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1121 0.1032
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0378 0.2333 1
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Toxoplasma gondii cathepsin CPC1 0.0106 0.0514 0.1236
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0378 0.2333 0.2333
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0106 0.0514 0.0418
Brugia malayi Cathepsin L-like precursor 0.0378 0.2333 0.2333
Trypanosoma brucei cysteine peptidase C (CPC) 0.0545 0.3448 1
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Echinococcus granulosus cathepsin L cysteine protease 0.0216 0.1251 0.1163
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0106 0.0514 0.2203
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0378 0.2333 0.6669
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1121 0.1121
Onchocerca volvulus 0.0378 0.2333 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0106 0.0514 0.0514
Schistosoma mansoni hypothetical protein 0.0205 0.1174 0.1085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0177 0.0078
Brugia malayi cathepsin Z-like cysteine proteinase 0.0106 0.0514 0.0514
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Leishmania major cysteine peptidase A (CPA) 0.0378 0.2333 0.6766
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.01 0.01
Echinococcus granulosus cathepsin b 0.1528 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0378 0.2333 0.2255
Plasmodium vivax vivapain-2 0.0378 0.2333 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0514 0.0418
Trypanosoma cruzi cysteine proteinase, putative 0.0216 0.1251 0.1163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Loa Loa (eye worm) cathepsin B 0.0545 0.3448 0.3448
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0216 0.1251 0.1163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0514 0.1236
Plasmodium vivax unspecified product 0.0216 0.1251 0.4054
Loa Loa (eye worm) hypothetical protein 0.0268 0.1595 0.1595
Schistosoma mansoni cathepsin s 0.0111 0.0546 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0514 0.1236
Schistosoma mansoni hypothetical protein 0.0205 0.1174 0.1085
Schistosoma mansoni alpha-glucosidase 0.0169 0.0939 0.0847
Echinococcus multilocularis cathepsin b 0.1528 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0514 0.0418
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0378 0.2333 0.2333
Toxoplasma gondii preprocathepsin c precursor, putative 0.0106 0.0514 0.1236
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0 0.5
Echinococcus multilocularis cathepsin L 0.0216 0.1251 0.1163
Loa Loa (eye worm) hypothetical protein 0.1528 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0216 0.1251 0.5364
Brugia malayi Cathepsin L-like precursor 0.0378 0.2333 0.2333
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1528 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0106 0.0514 0.0514
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1121 0.1032
Plasmodium vivax vivapain-1 0.0216 0.1251 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Entamoeba histolytica cysteine proteinase, putative 0.0216 0.1251 0.5364
Echinococcus granulosus cathepsin l1 0.0378 0.2333 0.2255
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0106 0.0514 0.1236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0268 0.1595 0.151
Brugia malayi cathepsin L-like cysteine proteinase 0.0106 0.0514 0.0514
Brugia malayi Papain family cysteine protease containing protein 0.0378 0.2333 0.2333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Echinococcus multilocularis cathepsin b 0.1528 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0106 0.0514 0.0418
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Brugia malayi Cathepsin L-like precursor 0.0378 0.2333 0.2333
Brugia malayi Papain family cysteine protease containing protein 0.0216 0.1251 0.1251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Entamoeba histolytica cysteine protease, putative 0.0106 0.0514 0.2203
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Onchocerca volvulus 0.0378 0.2333 1
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0514 0.0514
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0111 0.0546 0.0546
Toxoplasma gondii cathepsin B 0.0545 0.3448 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Entamoeba histolytica cysteine proteinase, putative 0.0216 0.1251 0.5364
Brugia malayi cathepsin F-like cysteine proteinase 0.0106 0.0514 0.0514
Entamoeba histolytica cysteine protease, putative 0.0106 0.0514 0.2203
Loa Loa (eye worm) hypothetical protein 0.0106 0.0514 0.0514
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Echinococcus granulosus cathepsin L cysteine proteinase 0.0378 0.2333 0.2255
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0177 0.0177
Trypanosoma cruzi cruzipain precursor, putative 0.0111 0.0546 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Loa Loa (eye worm) cysteine protease 0.0378 0.2333 0.2333
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0378 0.2333 0.6669
Plasmodium falciparum cysteine proteinase falcipain 3 0.0378 0.2333 1
Onchocerca volvulus 0.0378 0.2333 1
Brugia malayi Cathepsin L-like precursor 0.0378 0.2333 0.2333
Onchocerca volvulus 0.0378 0.2333 1
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0514 0.1236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0 0.5
Schistosoma mansoni cathepsin S (C01 family) 0.0106 0.0514 0.0418
Brugia malayi cathepsin L-like precursor 0.0268 0.1595 0.1595
Brugia malayi Cathepsin L-like precursor 0.0268 0.1595 0.1595
Brugia malayi cathepsin L precursor 0.0106 0.0514 0.0514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0514 0.1236
Onchocerca volvulus 0.0378 0.2333 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0514 0.1236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Echinococcus multilocularis cysteine protease 0.0378 0.2333 0.2255
Onchocerca volvulus 0.0114 0.0568 0.2436
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.01 0.01
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0514 0.0418
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0177 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0268 0.1595 0.4466
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0514 0.0418
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.0546 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Loa Loa (eye worm) hypothetical protein 0.0106 0.0514 0.0514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0177 0.0078
Onchocerca volvulus 0.0378 0.2333 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0545 0.3448 1
Toxoplasma gondii cathepsin CPL 0.0378 0.2333 0.6669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0216 0.1251 0.1163
Brugia malayi Papain family cysteine protease containing protein 0.0216 0.1251 0.1251
Brugia malayi Cathepsin L-like precursor 0.0378 0.2333 0.2333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0177 0.0078
Toxoplasma gondii cathepsin CPC2 0.0106 0.0514 0.1236
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0514 0.0418
Entamoeba histolytica cysteine proteinase 2 0.0216 0.1251 0.5364
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0514 0.1236
Mycobacterium ulcerans hypothetical protein 0.0029 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Entamoeba histolytica cysteine proteinase 1, putative 0.0216 0.1251 0.5364
Entamoeba histolytica hypothetical protein 0.0106 0.0514 0.2203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1251 0.3438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1528 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1528 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0378 0.2333 0.2255
Onchocerca volvulus 0.0378 0.2333 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0106 0.0514 0.0418
Schistosoma mansoni alpha-glucosidase 0.0169 0.0939 0.0847
Echinococcus granulosus geminin 0.0205 0.1174 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0514 0.1236
Echinococcus multilocularis cathepsin L 0.0106 0.0514 0.0418
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0378 0.2333 0.2255
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0514 0.0418
Entamoeba histolytica cysteine proteinase, putative 0.0378 0.2333 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0545 0.3448 0.3381
Onchocerca volvulus 0.0106 0.0514 0.2203
Plasmodium falciparum cysteine proteinase falcipain 1 0.0216 0.1251 0.4054
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Loa Loa (eye worm) hypothetical protein 0.0268 0.1595 0.1595
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0514 0.0514
Onchocerca volvulus Cathepsin L homolog 0.0378 0.2333 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0268 0.1595 0.1595
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0545 0.3448 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0216 0.1251 0.3438
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1121 0.1121
Loa Loa (eye worm) hypothetical protein 0.0106 0.0514 0.0514
Plasmodium vivax unspecified product 0.0111 0.0546 0.0178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0177 0.0078
Brugia malayi Cathepsin L-like precursor 0.0111 0.0546 0.0546
Entamoeba histolytica cysteine proteinase, putative 0.0216 0.1251 0.5364
Onchocerca volvulus 0.0268 0.1595 0.6839
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0216 0.1251 0.1163
Echinococcus multilocularis geminin 0.0205 0.1174 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0106 0.0514 0.1236
Trypanosoma cruzi cysteine peptidase, putative 0.0378 0.2333 0.2255
Plasmodium vivax vivapain-3 0.0216 0.1251 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1251 0.3438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0514 0.0418
Echinococcus granulosus cathepsin L 0.0216 0.1251 0.1163
Entamoeba histolytica cysteine protease, putative 0.0106 0.0514 0.2203
Echinococcus granulosus cathepsin l cysteine peptidase 0.0378 0.2333 0.2255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Loa Loa (eye worm) hypothetical protein 0.0378 0.2333 0.2333
Entamoeba histolytica cysteine protease, putative 0.0106 0.0514 0.2203
Loa Loa (eye worm) hypothetical protein 0.0268 0.1595 0.1595
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.01 0.0291
Trypanosoma cruzi cysteine peptidase, putative 0.0378 0.2333 0.2255
Giardia lamblia Cathepsin B precursor 0.0545 0.3448 1
Brugia malayi Cathepsin L-like precursor 0.0378 0.2333 0.2333
Echinococcus granulosus cysteine protease 0.0216 0.1251 0.1163
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1528 1 1
Plasmodium vivax vivapain-2 0.0378 0.2333 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0514 0.1236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0514 0.1236
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0106 0.0514 0.0514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0177 0.0078
Entamoeba histolytica cysteine protease, putative 0.0106 0.0514 0.2203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0514 0.1236
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0514 0.1236
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0 0.5
Echinococcus granulosus cathepsin L 0.0106 0.0514 0.0418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0378 0.2333 0.6669
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0216 0.1251 0.3438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Loa Loa (eye worm) hypothetical protein 0.0106 0.0514 0.0514
Onchocerca volvulus Cathepsin F homolog 0.0378 0.2333 1
Trypanosoma cruzi cysteine peptidase, putative 0.0216 0.1251 0.1163
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0106 0.0514 0.1236
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0514 0.1236
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0106 0.0514 0.2203
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0378 0.2333 0.2255
Echinococcus multilocularis cathepsin L cysteine protease 0.0378 0.2333 0.2255
Entamoeba histolytica cysteine proteinase, putative 0.0268 0.1595 0.6839
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0106 0.0514 0.1236
Entamoeba histolytica cysteine protease, putative 0.0378 0.2333 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1121 0.1032
Brugia malayi cathepsin Z-like cysteine proteinase 0.0106 0.0514 0.0514
Onchocerca volvulus Cathepsin L homolog 0.0378 0.2333 1
Echinococcus multilocularis cysteine protease 0.0378 0.2333 0.2255
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0177 0.0078
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0111 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.0106 0.0514 0.0514
Trypanosoma cruzi cysteine proteinase, putative 0.0216 0.1251 0.1163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0514 0.1236
Giardia lamblia Cathepsin B precursor 0.0545 0.3448 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0106 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Schistosoma mansoni cathepsin B (C01 family) 0.0106 0.0514 0.0418
Echinococcus granulosus cathepsin l1 0.0268 0.1595 0.151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Giardia lamblia Cathepsin B precursor 0.0545 0.3448 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0111 0.0546 0.0546
Brugia malayi Cathepsin L-like precursor 0.0268 0.1595 0.1595
Schistosoma mansoni cathepsin F (C01 family) 0.0378 0.2333 0.2255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.01 0.043
Schistosoma mansoni cathepsin F (C01 family) 0.0378 0.2333 0.2255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0378 0.2333 0.6669
Echinococcus granulosus cathepsin b 0.1528 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0514 0.1236
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1528 1 1
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Onchocerca volvulus Cathepsin L homolog 0.0106 0.0514 0.2203
Loa Loa (eye worm) ctsf protein 0.0378 0.2333 0.2333
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0111 0.0546 0.0546
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Brugia malayi fibroinase precursor 0.0106 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0268 0.1595 0.4466
Schistosoma mansoni cathepsin C 0.0106 0.0514 0.0418
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0545 0.3448 0.3381
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0177 0.0078
Loa Loa (eye worm) fibroinase 0.0378 0.2333 0.2333
Entamoeba histolytica cysteine protease, putative 0.0216 0.1251 0.5364
Trypanosoma cruzi cysteine protease, putative 0.0216 0.1251 0.1163
Trypanosoma cruzi cruzipain precursor, putative 0.0378 0.2333 0.2255
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0106 0.0514 0.2203
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0378 0.2333 1
Schistosoma mansoni cathepsin F (C01 family) 0.0268 0.1595 0.151
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0216 0.1251 0.1163
Trypanosoma cruzi cysteine peptidase, putative 0.0378 0.2333 0.2255
Loa Loa (eye worm) hypothetical protein 0.0111 0.0546 0.0546
Entamoeba histolytica cysteine proteinase, putative 0.0378 0.2333 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0546 0.0546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2333 0.6669
Leishmania major cathepsin L-like protease 0.0378 0.2333 0.6766
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.01 0.043

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 9.5283 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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