TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 767.006 | Formula: C34H34Cl3N3O11
H donors: 7 H acceptors: 8 LogP: 4.72 Rotable bonds: 8
Rule of 5 violations (Lipinski): 3
SMILES: OC/C(=N\NC(=O)c1ccc(c(c1)Cl)Cl)/[C@@]1(O)C[C@H](O[C@H]2C[C@H](N)[C@@H]([C@@H](O2)C)O)c2c(C1)c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2OC.Cl
InChi: 1S/C34H33Cl2N3O11.ClH/c1-13-28(41)19(37)9-23(49-13)50-21-11-34(47,22(12-40)38-39-33(46)14-6-7-17(35)18(36)8-14)10-16-25(21)32(45)27-26(30(16)43)29(42)15-4-3-5-20(48-2)24(15)31(27)44;/h3-8,13,19,21,23,28,40-41,43,45,47H,9-12,37H2,1-2H3,(H,39,46);1H/b38-22+;/t13-,19-,21-,23-,28+,34-;/m0./s1
InChiKey: DFODJOCFAAIAJF-LFWQVYDSSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0023	0.0039	0.0026
Loa Loa (eye worm)	aspartyl protease 6	0.0048	0.0224	0.0266
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Onchocerca volvulus		0.0069	0.037	0.0842
Schistosoma mansoni	amine GPCR	0.0069	0.037	0.0357
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0073	0.04	0.0408
Loa Loa (eye worm)	hypothetical protein	0.006	0.0309	0.0373
Brugia malayi	phosphoinositide-dependent protein kinase I	0.1122	0.7927	1
Echinococcus granulosus	bloom syndrome protein	0.0055	0.0269	0.0257
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.037	0.0357
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0126	0.0849
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Schistosoma mansoni	serine/threonine protein kinase	0.1122	0.7927	0.7925
Echinococcus granulosus	orexin receptor type 2	0.0069	0.037	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0198	0.495
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0095	0.0612
Trichomonas vaginalis	DNA polymerase eta, putative	0.0073	0.04	0.0408
Echinococcus granulosus	dna polymerase kappa	0.0073	0.04	0.0387
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0198	0.495
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0069	0.037	0.0357
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0041	0.0169	0.0156
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0069	0.037	0.0357
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0023	0.0039	0.0032
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0048	0.0224	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0188	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0069	0.037	0.0357
Onchocerca volvulus		0.0069	0.037	0.0842
Trichomonas vaginalis	AGC family protein kinase	0.1122	0.7927	1
Echinococcus granulosus	neuropeptide receptor A26	0.0069	0.037	0.0357
Echinococcus granulosus	g-protein coupled receptor	0.0069	0.037	0.0357
Schistosoma mansoni	gabp alpha	0.0087	0.0504	0.0491
Schistosoma mansoni	DNA helicase recq5	0.0023	0.0039	0.0026
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	biogenic amine receptor	0.0069	0.037	0.0357
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.037	0.0357
Schistosoma mansoni	ets-related	0.0265	0.1782	0.1771
Echinococcus granulosus	hypothetical protein	0.0069	0.037	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Brugia malayi	Dopamine receptor	0.0069	0.037	0.0451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.037	0.0357
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.037	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0136	0.3392
Brugia malayi	sulfakinin receptor protein	0.0069	0.037	0.0451
Trypanosoma cruzi	DNA polymerase eta, putative	0.0072	0.039	0.9749
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.1122	0.7927	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0136	0.3392
Echinococcus granulosus	neuropeptide FF receptor 2	0.0069	0.037	0.0357
Brugia malayi	G-protein coupled receptor	0.0069	0.037	0.0451
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0029	0.0086	0.1939
Brugia malayi	polk-prov protein	0.0045	0.0198	0.0233
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0069	0.037	0.0357
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0069	0.037	0.0451
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.037	0.0357
Schistosoma mansoni	memapsin-2 (A01 family)	0.0048	0.0224	0.0211
Onchocerca volvulus		0.0069	0.037	0.0842
Loa Loa (eye worm)	fli-1 protein	0.0265	0.1782	0.2235
Brugia malayi	Fli-1 protein	0.0265	0.1782	0.2235
Brugia malayi	G-protein coupled receptor	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus granulosus	GA binding protein alpha chain	0.0087	0.0504	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0603	0.4204	0.4197
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0027	0.0069	0.1445
Schistosoma mansoni	growth hormone secretagogue receptor	0.0069	0.037	0.0357
Brugia malayi	hypothetical protein	0.0043	0.0188	0.0221
Leishmania major	DNA polymerase eta, putative	0.0072	0.039	1
Onchocerca volvulus		0.0291	0.1962	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.037	0.0357
Brugia malayi	ORL1-like opioid receptor	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	hypothetical protein	0.002	0.0018	0.0005
Plasmodium falciparum	plasmepsin VII	0.0048	0.0224	0.1579
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0069	0.037	0.0451
Echinococcus multilocularis	serotonin receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.037	0.0357
Toxoplasma gondii	aspartyl protease	0.0048	0.0224	0.1579
Trichomonas vaginalis	DNA helicase recq, putative	0.0029	0.0086	0.0009
Plasmodium vivax	aspartyl protease, putative	0.0048	0.0224	0.1579
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.0039	0.019
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0095	0.0612
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0069	0.037	0.0357
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0069	0.037	0.0357
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.037	0.0357
Schistosoma mansoni	hypothetical protein	0.0069	0.037	0.0357
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.037	0.0357
Plasmodium falciparum	plasmepsin VIII, putative	0.0048	0.0224	0.1579
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.037	0.0451
Brugia malayi	Importin beta-1 subunit	0.0035	0.0126	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	G protein-coupled receptor	0.0069	0.037	0.0451
Loa Loa (eye worm)	TYRA-2 protein	0.0069	0.037	0.0451
Schistosoma mansoni	amine GPCR	0.0069	0.037	0.0357
Echinococcus granulosus	dna polymerase eta	0.0072	0.039	0.0377
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0136	0.3392
Entamoeba histolytica	recQ family helicase, putative	0.0029	0.0086	0.0009
Schistosoma mansoni	neuropeptide receptor	0.0069	0.037	0.0357
Plasmodium falciparum	plasmepsin I	0.0205	0.1344	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	Serotonin receptor	0.0069	0.037	0.0451
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0048	0.0224	0.0266
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0205	0.1344	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Trypanosoma brucei	unspecified product	0.0065	0.0342	0.8569
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Onchocerca volvulus		0.0069	0.037	0.0842
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0069	0.037	0.0842
Toxoplasma gondii	aspartyl protease ASP1	0.0205	0.1344	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0172	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2544	0.3198
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	hypothetical protein	0.0069	0.037	0.0357
Brugia malayi	follicle stimulating hormone receptor	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0049	0.0226	0.5655
Plasmodium falciparum	plasmepsin V	0.0048	0.0224	0.1579
Onchocerca volvulus		0.0069	0.037	0.0842
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0041	0.0169	0.0115
Brugia malayi	Melatonin receptor type 1A	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0095	0.0612
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0041	0.0169	0.0156
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0188	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus multilocularis	GA binding protein alpha chain	0.0087	0.0504	0.0491
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0057	0.0286	0.0264
Leishmania major	hypothetical protein, conserved	0.003	0.0095	0.2165
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	Dopamine receptor protein 1	0.0069	0.037	0.0451
Brugia malayi	Pepsin A precursor	0.0048	0.0224	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Onchocerca volvulus		0.0069	0.037	0.0842
Brugia malayi	aspartic protease BmAsp-1, identical	0.0048	0.0224	0.0266
Echinococcus multilocularis	snurportin 1	0.0372	0.2544	0.2534
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0069	0.037	0.0451
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0205	0.1344	0.1612
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.04	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.0039	0.0032
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0069	0.037	0.0357
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0095	0.2111
Brugia malayi	larval opioid receptor	0.0069	0.037	0.0451
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0069	0.037	0.0357
Brugia malayi	Protein kinase domain containing protein	0.1122	0.7927	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0095	0.0612
Echinococcus granulosus	g protein coupled receptor	0.0069	0.037	0.0357
Entamoeba histolytica	hypothetical protein	0.0043	0.0188	0.0139
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0069	0.037	0.0842
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.037	0.0357
Echinococcus granulosus	g protein coupled receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0309	0.0373
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0095	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0224	0.0266
Trichomonas vaginalis	DNA helicase recq1, putative	0.0055	0.0269	0.0242
Entamoeba histolytica	protein kinase, putative	0.1122	0.7927	1
Schistosoma mansoni	histamine h1 receptor	0.0069	0.037	0.0357
Trypanosoma cruzi	DNA polymerase eta, putative	0.0043	0.0188	0.4523
Echinococcus granulosus	7tm_1 domain containing protein	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0205	0.1344	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0072	0.039	0.0476
Echinococcus granulosus	serotonin receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0087	0.0504	0.062
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.04	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0023	0.0039	0.0026
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Echinococcus granulosus	neuropeptide s receptor	0.0069	0.037	0.0357
Brugia malayi	hypothetical protein	0.003	0.0095	0.0103
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.1122	0.7927	0.7925
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	neuropeptide receptor	0.0069	0.037	0.0357
Brugia malayi	putative neuropeptide receptor	0.0069	0.037	0.0451
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.037	0.0451
Plasmodium falciparum	plasmepsin IV	0.0205	0.1344	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0069	0.037	0.0357
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0023	0.0039	0.0026
Loa Loa (eye worm)	pax transcription factor protein 2	0.0291	0.1962	0.2462
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	neuropeptide receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Onchocerca volvulus		0.0069	0.037	0.0842
Onchocerca volvulus		0.0069	0.037	0.0842
Echinococcus granulosus	7TM GPCR rhodopsin	0.0069	0.037	0.0357
Loa Loa (eye worm)	RecQ helicase	0.0055	0.0269	0.0324
Schistosoma mansoni	blooms syndrome DNA helicase	0.0043	0.0187	0.0174
Brugia malayi	MH2 domain containing protein	0.0144	0.0911	0.1134
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0041	0.0169	0.7315
Echinococcus multilocularis	sex peptide receptor	0.0069	0.037	0.0357
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.037	0.0357
Brugia malayi	hypothetical protein	0.0069	0.037	0.0451
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0079	0.1701
Brugia malayi	RE15519p	0.0069	0.037	0.0451
Onchocerca volvulus		0.0069	0.037	0.0842
Plasmodium vivax	aspartyl protease, putative	0.0048	0.0224	0.1579
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0079	0.1745
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0126	0.0849
Schistosoma mansoni	amine GPCR	0.0069	0.037	0.0357
Echinococcus multilocularis	allatostatin A receptor	0.0069	0.037	0.0357
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0023	0.0039	0.019
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0037	0.0142	0.0968
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0069	0.037	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0226	0.5665
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Schistosoma mansoni	tsg101-related	0.007	0.0378	0.0366
Schistosoma mansoni	opsin-like receptor	0.0069	0.037	0.0357
Schistosoma mansoni	amine GPCR	0.0069	0.037	0.0357
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0069	0.037	0.0357
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0172	0.02
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0069	0.037	0.0451
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0069	0.037	0.0357
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.037	0.0451
Schistosoma mansoni	hypothetical protein	0.0372	0.2544	0.2534
Schistosoma mansoni	tsg101-related	0.0057	0.0286	0.0274
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0043	0.0188	0.1312
Onchocerca volvulus		0.0069	0.037	0.0842
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0309	0.0373
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0041	0.0169	0.0156
Schistosoma mansoni	hypothetical protein	0.0069	0.037	0.0357
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.037	0.0357
Echinococcus granulosus	dro:myosuppressin receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus granulosus	somatostatin receptor	0.0069	0.037	0.0357
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.0039	0.019
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0037	0.0139	0.0944
Brugia malayi	Dopamine receptor protein 2	0.0069	0.037	0.0451
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.037	0.0357
Echinococcus granulosus	neuropeptide receptor	0.0069	0.037	0.0357
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.037	0.0357
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.037	0.0357
Brugia malayi	AKH receptor	0.0069	0.037	0.0451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Schistosoma mansoni	myosin xvIII	0.0069	0.037	0.0357
Trypanosoma brucei	unspecified product	0.0028	0.0078	0.1961
Onchocerca volvulus		0.0069	0.037	0.0842
Brugia malayi	GnHR receptor homolog	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	Ets-domain containing protein	0.0087	0.0504	0.062
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0911	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Trichomonas vaginalis	AGC family protein kinase	0.1122	0.7927	1
Leishmania major	DNA polymerase eta, putative	0.0043	0.0188	0.4639
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	somatostatin receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	dna polymerase kappa	0.0073	0.04	0.0387
Echinococcus multilocularis	neuropeptide receptor	0.1411	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0069	0.037	0.0451
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.037	0.0357
Schistosoma mansoni	DNA helicase recq1	0.0023	0.0039	0.0026
Plasmodium falciparum	plasmepsin IX	0.0048	0.0224	0.1579
Echinococcus multilocularis	orexin receptor type 2	0.0069	0.037	0.0357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Brugia malayi	Pax transcription factor protein 2	0.0291	0.1962	0.2462
Schistosoma mansoni	adenoreceptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0911	0.1134
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0069	0.037	0.0451
Schistosoma mansoni	amine GPCR	0.0069	0.037	0.0357
Schistosoma mansoni	DNA polymerase eta	0.0072	0.039	0.0377
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0224	0.0266
Loa Loa (eye worm)	hypothetical protein	0.003	0.0095	0.0103
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0198	0.0233
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0095	0.2376
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Onchocerca volvulus		0.0069	0.037	0.0842
Echinococcus granulosus	sex peptide receptor	0.0069	0.037	0.0357
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0069	0.037	0.0357
Plasmodium falciparum	plasmepsin II	0.0205	0.1344	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Giardia lamblia	DINP protein human, muc B family	0.0049	0.0226	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0069	0.037	0.0357
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0084	0.0479	0.0467
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0048	0.0224	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0069	0.037	0.0357
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0041	0.0169	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0413	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0479	0.0589
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.0039	0.0032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.037	0.0357
Schistosoma mansoni	neuropeptide receptor	0.0069	0.037	0.0357
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0027	0.0069	0.1733
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0309	0.0373
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Plasmodium falciparum	plasmepsin VI	0.0205	0.1344	1
Plasmodium falciparum	plasmepsin III	0.0048	0.0224	0.1579
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.037	0.0357
Entamoeba histolytica	hypothetical protein	0.0043	0.0188	0.0139
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0126	0.0113
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0048	0.0222	0.1565
Entamoeba histolytica	hypothetical protein	0.0043	0.0188	0.0139
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.037	0.0357
Plasmodium falciparum	importin beta, putative	0.0035	0.0126	0.0849
Brugia malayi	G protein-coupled receptor F59B2.13	0.0069	0.037	0.0451
Brugia malayi	hypothetical protein	0.0048	0.0224	0.0266
Brugia malayi	hypothetical protein	0.0048	0.0224	0.0266
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0029	0.0086	0.2164
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.037	0.0357
Schistosoma mansoni	biogenic amine receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0023	0.0039	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Onchocerca volvulus		0.0069	0.037	0.0842
Echinococcus multilocularis	G protein coupled receptor 139	0.1411	1	1
Plasmodium vivax	plasmepsin IV, putative	0.0205	0.1344	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0029	0.0086	0.1891
Brugia malayi	Ets-domain containing protein	0.0087	0.0504	0.062
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.037	0.0357
Echinococcus multilocularis	neuropeptide s receptor	0.0069	0.037	0.0357
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.037	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Schistosoma mansoni	opsin-like receptor	0.0069	0.037	0.0357
Brugia malayi	hypothetical protein	0.0084	0.0479	0.0589
Echinococcus granulosus	G protein coupled receptor 139	0.0069	0.037	0.0357
Echinococcus multilocularis	serotonin receptor	0.0069	0.037	0.0357
Schistosoma mansoni	neuropeptide receptor	0.1411	1	1
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.1122	0.7927	1
Echinococcus multilocularis	g-protein coupled receptor	0.0069	0.037	0.0357
Onchocerca volvulus		0.0069	0.037	0.0842
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Brugia malayi	Bloom's syndrome protein homolog	0.0055	0.0269	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0205	0.1344	0.1333
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0172	0.02
Entamoeba histolytica	hypothetical protein	0.0043	0.0188	0.0139
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0126	0.3163
Schistosoma mansoni	tsg101-related	0.007	0.0378	0.0366
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.037	0.0357
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Echinococcus multilocularis	dna polymerase eta	0.0072	0.039	0.0377
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0188	0.0175
Trypanosoma brucei	DNA polymerase eta, putative	0.0072	0.039	0.9758
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0205	0.1344	0.1333
Onchocerca volvulus		0.0069	0.037	0.0842
Echinococcus granulosus	snurportin 1	0.0372	0.2544	0.2534
Trichomonas vaginalis	DNA helicase recq, putative	0.0055	0.0269	0.0242
Mycobacterium ulcerans	DNA polymerase IV	0.0073	0.04	0.5
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0126	0.0113
Trichomonas vaginalis	hypothetical protein	0.0041	0.017	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	aspartic protease BmAsp-2, identical	0.0048	0.0224	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0166	0.1071	0.1337
Brugia malayi	putative neuropeptide receptor NPR1	0.0069	0.037	0.0451
Echinococcus granulosus	allatostatin A receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0069	0.037	0.0451
Plasmodium vivax	plasmepsin V, putative	0.0048	0.0224	0.1579
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.1122	0.7927	0.7925
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.037	0.0451
Echinococcus multilocularis	bloom syndrome protein	0.0055	0.0269	0.0257
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Brugia malayi	ImpB/MucB/SamB family protein	0.0041	0.0169	0.0197
Brugia malayi	ImpB/MucB/SamB family protein	0.0072	0.039	0.0476
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.037	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0049	0.0226	1
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0069	0.037	0.0357
Trypanosoma brucei	unspecified product	0.0028	0.0078	0.1961
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0069	0.037	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.037	0.0357
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.04	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0069	0.037	0.0451
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.037	0.0357
Echinococcus granulosus	fmrfamide receptor	0.0069	0.037	0.0357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Loa Loa (eye worm)	melatonin receptor type 1A	0.0069	0.037	0.0451
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0205	0.1344	1
Onchocerca volvulus		0.0069	0.037	0.0842
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0084	0.0479	0.0467
Plasmodium falciparum	plasmepsin X	0.0048	0.0224	0.1579
Echinococcus multilocularis	dro:myosuppressin receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0224	0.0211
Schistosoma mansoni	importin beta-1	0.0035	0.0126	0.0113
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.04	1
Schistosoma mansoni	opsin-like receptor	0.0069	0.037	0.0357
Plasmodium vivax	aspartyl protease, putative	0.0048	0.0224	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0039	0.0032
Brugia malayi	Serotonin receptor	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Brugia malayi	neuropeptide F receptor	0.0069	0.037	0.0451
Brugia malayi	neuropeptide F receptor	0.0069	0.037	0.0451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Schistosoma mansoni	hypothetical protein	0.0069	0.037	0.0357
Trichomonas vaginalis	AGC family protein kinase	0.1122	0.7927	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0126	0.0143
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0041	0.0169	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.037	0.0357
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0069	0.037	0.0357
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0021	0.0025	0.0083
Plasmodium vivax	aspartyl proteinase, putative	0.0048	0.0224	0.1579
Brugia malayi	RNA, U transporter 1	0.0099	0.0587	0.0725
Onchocerca volvulus		0.0069	0.037	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1344	0.1682
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0013	0.0337
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0126	0.3163
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.037	0.0357
Leishmania major	hypothetical protein, conserved	0.0027	0.0069	0.1482
Echinococcus granulosus	g protein coupled receptor	0.0069	0.037	0.0357
Trypanosoma brucei	DNA polymerase IV, putative	0.0065	0.0342	0.8569
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0069	0.037	0.0357
Plasmodium vivax	aspartyl proteinase, putative	0.0205	0.1344	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.04	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0069	0.037	0.0357
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0069	0.037	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.04	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.037	0.0451
Leishmania major	DNA polymerase kappa, putative	0.0049	0.0226	0.5655
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0013	0.0337
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.037	0.0357
Schistosoma mansoni	cathepsin D (A01 family)	0.0603	0.4204	0.4197
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.037	0.0357
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0069	0.037	0.0451
Schistosoma mansoni	biogenic amine receptor	0.0069	0.037	0.0357
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0188	0.0175
Mycobacterium ulcerans	DNA polymerase IV	0.0073	0.04	0.5
Toxoplasma gondii	aspartyl protease ASP3	0.0048	0.0224	0.1579
Echinococcus multilocularis	neuropeptide receptor A26	0.0069	0.037	0.0357
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.04	1

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 6.6 uM	Inhibition of DNA synthesis in mouse L1210 cells	ChEMBL.	690999

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3244761

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1891014