Detailed information for compound 1943216

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.414 | Formula: C22H17F2N7
  • H donors: 2 H acceptors: 4 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc(C)nc(c1)c1[nH]c(nc1c1ccc2n(c1)ncn2)CNc1ccccc1F
  • InChi: 1S/C22H17F2N7/c1-13-8-15(23)9-18(28-13)22-21(14-6-7-20-26-12-27-31(20)11-14)29-19(30-22)10-25-17-5-3-2-4-16(17)24/h2-9,11-12,25H,10H2,1H3,(H,29,30)
  • InChiKey: CMDOQJWYHZTTIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens activin A receptor, type IB Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus TGF beta receptor type 1 Get druggable targets OG5_129709 All targets in OG5_129709
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma mansoni protein kinase Get druggable targets OG5_129709 All targets in OG5_129709
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase Get druggable targets OG5_129709 All targets in OG5_129709
Echinococcus multilocularis TGF beta receptor type 1 Get druggable targets OG5_129709 All targets in OG5_129709
Brugia malayi bone morphogenetic protein type 1 receptor Get druggable targets OG5_129709 All targets in OG5_129709
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04674 transforming growth factor, beta receptor I, putative Get druggable targets OG5_129709 All targets in OG5_129709
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus TGF-beta receptor type-1 Get druggable targets OG5_129709 All targets in OG5_129709
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0047 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0099 0.0224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0215 0.0215
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0335 0.3987 1
Echinococcus granulosus geminin 0.0199 0.2264 0.2264
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0335 0.3987 1
Echinococcus multilocularis zinc finger protein 0.0023 0.0037 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0047 0.0047
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0649 0.0649
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0047 0.0047
Brugia malayi bone morphogenetic protein type 1 receptor 0.0191 0.2164 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0121 0.028
Schistosoma mansoni hypothetical protein 0.0034 0.018 0.018
Echinococcus multilocularis geminin 0.0199 0.2264 0.2264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0649 0.1607
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0271 0.0271
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0335 0.3987 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0797 0.3686
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.1165 0.1165
Brugia malayi jmjC domain containing protein 0.0044 0.0299 0.1192
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1672 0.1672
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0299 0.0299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0117 0.1228 0.558
Treponema pallidum hypothetical protein 0.0335 0.3987 0.5
Schistosoma mansoni protein kinase 0.0086 0.0836 0.0836
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0649 0.3495
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0047 0.0047
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0299 0.0299
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0047 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.152 0.7027
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0121 0.028
Schistosoma mansoni bromodomain containing protein 0.0074 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.005 0.038 0.1758
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.1672 0.1672
Brugia malayi hypothetical protein 0.0042 0.0281 0.1107
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0082 0.0082
Schistosoma mansoni coup transcription factor 0.0024 0.0047 0.0047
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.1672 0.7729
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0047 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0121 0.028
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1672 1
Schistosoma mansoni hypothetical protein 0.0199 0.2264 0.2264
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0281 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0047 0.0217
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0047 0.0047
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0047 0.0047
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0074 0.0687 0.3173
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1672 0.1672
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.018 0.018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0215 0.0796
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0099 0.0245
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0099 0.0224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0047 0.0047
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.018 0.1112
Leishmania major hypothetical protein, conserved 0.003 0.0121 0.0141
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0335 0.3987 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0045
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0649 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0649 0.1607
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0649 0.0649
Giardia lamblia PHD finger protein 15 0.0034 0.018 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0641 0.2963
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.1672 1
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0759 0.3365
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0634 0.0634
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0099 0.0245
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.1672 0.1672
Schistosoma mansoni hypothetical protein 0.008 0.0759 0.0759
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0047 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0649 0.1607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0634 0.0634
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0874 0.0874
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1672 0.1672
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0099 0.0224
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0087 0.0847 0.0847
Brugia malayi P38 map kinase family protein 2 0.0152 0.1672 0.7679
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.001 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0649 0.0649
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0335 0.3987 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0082 0.0082
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0215 0.0995
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0047 0.0047
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.152 0.7027
Loa Loa (eye worm) hypothetical protein 0.0045 0.0317 0.1464
Schistosoma mansoni hypothetical protein 0.0037 0.0215 0.0215
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0281 0.0281
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0047 0.0217
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0426 0.197
Echinococcus granulosus activin receptor type 0.0087 0.0847 0.0847
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.018 0.1112
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0059 0.0489 0.2261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0426 0.0426
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0034 0.018 0.0831
Loa Loa (eye worm) hypothetical protein 0.0117 0.1228 0.5676
Echinococcus multilocularis GPCR, family 2 0.0037 0.0215 0.0215
Plasmodium falciparum phd finger protein, putative 0.0034 0.018 0.0427
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0426 0.0426
Brugia malayi protein C17H12.11 0.0074 0.0676 0.2972
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0099 0.0224
Schistosoma mansoni hypothetical protein 0.0037 0.0215 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0047 0.0217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0047 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0047 0.0047
Brugia malayi MH2 domain containing protein 0.014 0.152 0.6962
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0191 0.2164 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.056
Loa Loa (eye worm) hypothetical protein 0.0074 0.0676 0.3125
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0215 0.0215
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0047 0.0047
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0047 0.0047
Brugia malayi jmjC domain containing protein 0.0112 0.1165 0.5284
Entamoeba histolytica hypothetical protein 0.0042 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0045
Schistosoma mansoni hypothetical protein 0.0037 0.0215 0.0215
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0457
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0426 0.1792
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0426 0.0426
Brugia malayi PHD-finger family protein 0.0034 0.018 0.0628
Brugia malayi hypothetical protein 0.003 0.0121 0.0351
Mycobacterium ulcerans hypothetical protein 0.0028 0.0099 0.0224
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0053 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0426 0.0426
Brugia malayi Bromodomain containing protein 0.0088 0.0861 0.3846
Loa Loa (eye worm) hypothetical protein 0.0048 0.0352 0.1626
Echinococcus granulosus GPCR family 2 0.0037 0.0215 0.0215
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0099 0.0224
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0047 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0281 0.0281
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0099 0.0224
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0074 0.0687 0.3173
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0047 0.0047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0042 0.0281 0.0281
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1672 0.1672
Schistosoma mansoni hypothetical protein 0.0199 0.2264 0.2264
Echinococcus granulosus zinc finger protein 0.0023 0.0037 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0281 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0047 0.0217
Loa Loa (eye worm) hypothetical protein 0.008 0.0759 0.3509
Brugia malayi hypothetical protein 0.0074 0.0676 0.2972
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0426 0.0426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0047 0.0217
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0045
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0349 0.0349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0117 0.1228 0.558
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0099 0.0224
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0215 0.0796
Brugia malayi PHD-finger family protein 0.0029 0.0117 0.033
Echinococcus granulosus peregrin 0.0037 0.0215 0.0215
Brugia malayi Bromodomain containing protein 0.0045 0.0316 0.127
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0042 0.0281 1
Echinococcus multilocularis activin receptor type 0.0087 0.0847 0.0847
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0047 0.0217
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0047 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0034 0.018 0.0427
Echinococcus granulosus TGF beta receptor type 1 0.0192 0.2174 0.2174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0215 0.0995
Onchocerca volvulus Alhambra homolog 0.0034 0.018 1
Echinococcus multilocularis TGF beta receptor type 1 0.0192 0.2174 0.2174
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.018 0.0831
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0099 0.0245
Echinococcus multilocularis peregrin 0.0037 0.0215 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0047 0.0217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0047 0.0047
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0009 0.0042
Brugia malayi Protein kinase domain containing protein 0.0074 0.0687 0.3022
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0299 0.1383
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0047 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0426 0.0426
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1672 1
Onchocerca volvulus 0.0028 0.0099 0.3909
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0457
Brugia malayi Bromodomain containing protein 0.0037 0.0215 0.0794
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0099 0.0224
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.1165 0.1165
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.018 0.018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0047 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0099 0.0224
Schistosoma mansoni hypothetical protein 0.0037 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0457
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0047 0.0047
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0649 0.1607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0426 0.0426
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.1672 1
Entamoeba histolytica hypothetical protein 0.0042 0.0281 1
Echinococcus granulosus TGF-beta receptor type-1 0.0192 0.2174 0.2174
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.018 0.018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0281 0.0281
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0117 0.1228 0.5676
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0215 0.0215
Schistosoma mansoni zinc finger protein 0.0023 0.0037 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0649 0.0649
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0217
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0047 0.0047
Schistosoma mansoni protein kinase 0.0192 0.2174 0.2174
Entamoeba histolytica hypothetical protein 0.0042 0.0281 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0299 0.0299

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 41.9 nM Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase assay ChEMBL. 26483198
IC50 (binding) > 10000 nM Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay ChEMBL. 26483198

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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