Detailed information for compound 2000497

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 387.438 | Formula: C21H21N7O
  • H donors: 3 H acceptors: 5 LogP: 1.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(c1ccccn1)(C)C)Nc1ncc2c(c1)[nH]nc2c1ccnc(c1)C
  • InChi: 1S/C21H21N7O/c1-13-10-14(7-9-22-13)19-15-12-24-18(11-16(15)27-28-19)25-20(29)26-21(2,3)17-6-4-5-8-23-17/h4-12H,1-3H3,(H,27,28)(H2,24,25,26,29)
  • InChiKey: PWCFRJPZFNBBDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0043 0.0601 0.4076
Echinococcus granulosus translational activator gcn1 0.001 0.0009 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0043 0.0601 0.3815
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0.0042 0.0213
Loa Loa (eye worm) hypothetical protein 0.0261 0.4494 0.4489
Brugia malayi ORL1-like opioid receptor 0.001 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis mitogen activated protein kinase 3 0.0097 0.1562 0.1562
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0018 0.0143 0.0143
Leishmania major phosphatidylinositol kinase related protein, putative 0.0011 0.0033 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis g-protein coupled receptor 0.001 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0017 0.014 0.014
Schistosoma mansoni adenoreceptor 0.001 0.001 0.001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0687 0.0687
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0017 0.014 0.014
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Schistosoma mansoni opsin-like receptor 0.001 0.001 0.001
Schistosoma mansoni Smad4 0.001 0.0008 0.0008
Schistosoma mansoni myosin xvIII 0.001 0.001 0.001
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0042 0.0133
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.001 0.001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.001 0.001
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.005 0.0726 0.4536
Brugia malayi RNA recognition motif domain containing protein 0.0092 0.1477 0.5798
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1511 0.1503
Schistosoma mansoni ap endonuclease 0.0012 0.0042 0.0042
Echinococcus granulosus mitogen activated protein kinase 3 0.0097 0.1562 0.1562
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0164 0.0156
Echinococcus multilocularis fmrfamide receptor 0.001 0.001 0.001
Schistosoma mansoni importin-beta 2 0.001 0.0009 0.0009
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.001 0.001
Giardia lamblia Kinase, CMGC MAPK 0.0097 0.1562 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0687 0.0687
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0011 0.0033 0.0163
Echinococcus granulosus Smad4 0.001 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0011 0.0033 0.0033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0042 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Trypanosoma cruzi DNA repair protein, putative 0.0012 0.0042 0.0061
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0091 0.1462 1
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Toxoplasma gondii microneme protein MIC17B 0.0029 0.034 0.0426
Echinococcus granulosus neuropeptide Y receptor 0.001 0.001 0.001
Schistosoma mansoni smad1 5 8 and 0.001 0.0008 0.0008
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0039 0.053 0.3355
Echinococcus granulosus neuropeptides capa receptor 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0358 0.6224 0.6224
Echinococcus multilocularis somatostatin receptor 0.001 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus granulosus neuropeptides capa receptor 0.001 0.001 0.001
Brugia malayi G-protein coupled receptor 0.001 0.001 0.0006
Onchocerca volvulus 0.0029 0.034 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0016 0.0109 0.0109
Onchocerca volvulus 0.0029 0.034 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0014 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0012 0.0042 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0011 0.0033 0.0153
Schistosoma mansoni smad 0.001 0.0008 0.0008
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0008 0.0008
Echinococcus multilocularis importin 5 0.001 0.0009 0.0009
Schistosoma mansoni neuropeptide receptor 0.001 0.001 0.001
Onchocerca volvulus 0.0029 0.034 1
Echinococcus granulosus g-protein coupled receptor 0.001 0.001 0.001
Toxoplasma gondii PAN domain-containing protein 0.0444 0.7769 1
Schistosoma mansoni amine GPCR 0.001 0.001 0.001
Brugia malayi RNA binding protein 0.0092 0.1477 0.5798
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0033 0.0096
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0036 0.0473 0.0465
Echinococcus granulosus G protein coupled receptor 139 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.001 0.001 0.001
Echinococcus multilocularis transportin 1 0.001 0.0009 0.0009
Onchocerca volvulus 0.0029 0.034 1
Schistosoma mansoni hypothetical protein 0.0104 0.1683 0.1683
Brugia malayi RE15519p 0.001 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Entamoeba histolytica Ran family GTPase 0.0039 0.053 0.3585
Leishmania major DNA repair protein, putative 0.0012 0.0042 0.0213
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.001 0.001
Echinococcus granulosus neuropeptide s receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0011 0.0033 0.0033
Brugia malayi Serotonin receptor 0.001 0.001 0.0006
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1683 0.6612
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0332
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.001 0.0001
Schistosoma mansoni ran 0.0039 0.053 0.053
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.001 0.001
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0042 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0039 0.053 0.6744
Brugia malayi G-protein coupled receptor 0.001 0.001 0.0006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0011 0.0033 0.0153
Echinococcus granulosus g protein coupled receptor 0.001 0.001 0.001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.001 0.0001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0042 0.0427
Echinococcus multilocularis snurportin 1 0.0569 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0016 0.0109 0.0643
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0011 0.0033 0.0153
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0097 0.1562 1
Echinococcus granulosus hypothetical protein 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis translational activator gcn1 0.001 0.0009 0.0009
Schistosoma mansoni biogenic amine receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0152 0.2541 0.2535
Echinococcus multilocularis GPCR, family 2 0.0048 0.0687 0.0687
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.001 0.0001
Toxoplasma gondii HEAT repeat-containing protein 0.0053 0.0782 0.0996
Schistosoma mansoni neuropeptide receptor 0.001 0.001 0.001
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.001 0.001
Brugia malayi sulfakinin receptor protein 0.001 0.001 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0042 0.0213
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.001 0.001
Echinococcus granulosus serotonin receptor 0.001 0.001 0.001
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0097 0.1562 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1511 0.1511
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1511 0.1511
Onchocerca volvulus 0.0029 0.034 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis mitogen activated protein kinase 0.0097 0.1562 0.1562
Brugia malayi putative neuropeptide receptor 0.001 0.001 0.0006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0018 0.0143 0.0143
Schistosoma mansoni biogenic amine receptor 0.001 0.001 0.001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0011 0.0026 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0033 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.001 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.001 0.001
Schistosoma mansoni opsin-like receptor 0.001 0.001 0.001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0008 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.2541 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni hypothetical protein 0.001 0.001 0.001
Echinococcus multilocularis Smad4 0.001 0.0008 0.0008
Schistosoma mansoni histamine h1 receptor 0.001 0.001 0.001
Echinococcus multilocularis geminin 0.0358 0.6224 0.6224
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0011 0.0026 0.0026
Toxoplasma gondii microneme protein MIC17A 0.0029 0.034 0.0426
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.001 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.001 0.001
Brugia malayi Serotonin receptor 0.001 0.001 0.0006
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.001 0.001
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0011 0.0033 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.001 0.001 0.001
Schistosoma mansoni ap endonuclease 0.0012 0.0042 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0017 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0012 0.0042 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.001 0.001
Echinococcus granulosus neuropeptide receptor A26 0.001 0.001 0.001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.001 0.001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.001 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0687 0.0687
Schistosoma mansoni tar DNA-binding protein 0.0092 0.1477 0.1477
Loa Loa (eye worm) hypothetical protein 0.0261 0.4494 0.4489
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0351 0.0351
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.001 0.0006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.001 0.001
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.001 0.001
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0008 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1511 0.5932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Schistosoma mansoni bromodomain containing protein 0.0031 0.0382 0.0382
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.001 0.001
Echinococcus granulosus transportin 1 0.001 0.0009 0.0009
Echinococcus multilocularis fmrfamide receptor 0.001 0.001 0.001
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.0033 0.0003
Plasmodium vivax importin-beta 2, putative 0.0053 0.0782 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0033 0.0096
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.001 0.0006
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0011 0.0025 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0042 0.0427
Echinococcus granulosus somatostatin receptor 0.001 0.001 0.001
Loa Loa (eye worm) kap beta 3 protein 0.001 0.0009 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0091 0.1462 0.1462
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0687 0.0679
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0039 0.053 0.0671
Loa Loa (eye worm) hypothetical protein 0.007 0.1072 0.1065
Brugia malayi MAP kinase sur-1 0.0097 0.1562 0.6134
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0687 0.2679
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0097 0.1562 1
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Loa Loa (eye worm) hypothetical protein 0.0104 0.1683 0.1676
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.001 0.001
Toxoplasma gondii FATC domain-containing protein 0.0016 0.0109 0.0129
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.001 0.001
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.001 0.0006
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.034 0.0332
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.001 0.0001
Brugia malayi RNA, U transporter 1 0.0151 0.2538 0.999
Schistosoma mansoni smad1 5 8 and 0.001 0.0008 0.0008
Brugia malayi PHD-finger family protein 0.0012 0.0047 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Onchocerca volvulus 0.0029 0.034 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Toxoplasma gondii hypothetical protein 0.0029 0.034 0.0426
Leishmania major importin beta-1 subunit, putative 0.0043 0.0601 0.3815
Toxoplasma gondii microneme protein, putative 0.0029 0.034 0.0426
Echinococcus multilocularis allatostatin A receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.001 0.001
Trypanosoma brucei protein kinase, putative 0.0097 0.1562 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0042 0.0034
Toxoplasma gondii PAN domain-containing protein 0.0029 0.034 0.0426
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0039 0.053 0.3252
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0012 0.0042 0.0213
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.001 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.1562 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0332
Schistosoma mansoni amine GPCR 0.001 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Brugia malayi WGR domain containing protein 0.005 0.0726 0.2835
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0687 0.0687
Schistosoma mansoni amine GPCR 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0012 0.0042 0.0061
Echinococcus multilocularis serine protein kinase ATM 0.0016 0.0109 0.0109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.2541 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.001 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0465 0.8154 0.8154
Trypanosoma brucei importin beta-1 subunit, putative 0.0053 0.0782 0.4975
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1511 0.1511
Brugia malayi Importin beta-1 subunit 0.0053 0.0782 0.3053
Toxoplasma gondii target of rapamycin (TOR), putative 0.0011 0.0033 0.0031
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.034 0.0332
Echinococcus multilocularis neuropeptide receptor 0.001 0.001 0.001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0011 0.0033 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0012 0.0042 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0013 0.007 0.0242
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0039 0.053 0.053
Toxoplasma gondii microneme protein MIC4 0.0029 0.034 0.0426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.001 0.0006
Echinococcus granulosus poly ADP ribose polymerase 1 0.0091 0.1462 0.1462
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.001 0.001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0012 0.0042 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.001 0.001
Schistosoma mansoni neuropeptide receptor 0.001 0.001 0.001
Echinococcus granulosus tar DNA binding protein 0.0092 0.1477 0.1477
Brugia malayi neuropeptide F receptor 0.001 0.001 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0008 0.0008
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0011 0.0033 0.0033
Brugia malayi hypothetical protein 0.0017 0.014 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0109 0.0643
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Echinococcus multilocularis neuropeptide receptor 0.001 0.001 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0042 0.0213
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0092 0.1477 0.1477
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0097 0.1562 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.0109 0.0498
Echinococcus granulosus WGR domain containing protein 0.0028 0.0336 0.0336
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.001 0.001
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.034 0.0332
Onchocerca volvulus 0.0029 0.034 1
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.001 0.001
Echinococcus granulosus allatostatin A receptor 0.001 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.001 0.001
Toxoplasma gondii PAN domain-containing protein 0.0029 0.034 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.1562 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1562 0.1562
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.1562 1
Echinococcus granulosus serine protein kinase ATM 0.0016 0.0109 0.0109
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0012 0.0042 0.0213
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0091 0.1462 0.1462
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0033 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus granulosus poly adp ribose polymerase 2 0.005 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Trichomonas vaginalis importin beta-1, putative 0.0043 0.0601 0.3815
Echinococcus granulosus poly (ADP ribose) polymerase 0.0028 0.0336 0.0336
Brugia malayi WGR domain containing protein 0.0091 0.1462 0.5742
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.001 0.001
Echinococcus granulosus geminin 0.0358 0.6224 0.6224
Loa Loa (eye worm) PHD-finger family protein 0.001 0.0009 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.001 0.0001
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.001 0.001
Onchocerca volvulus 0.0029 0.034 1
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0177
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0097 0.1562 1
Echinococcus granulosus importin subunit beta 1 0.0053 0.0782 0.0782
Echinococcus granulosus GTP binding nuclear protein Ran 0.0039 0.053 0.053
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0042 0.0042
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0039 0.053 0.3252
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0011 0.0033 0.0163
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.005 0.0726 0.4536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.034 0.0332
Schistosoma mansoni hypothetical protein 0.001 0.001 0.001
Toxoplasma gondii subtilisin SUB12 0.0029 0.034 0.0426
Schistosoma mansoni biogenic amine receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus granulosus neuropeptide receptor 0.001 0.001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.001 0.001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0008 0.0008
Echinococcus granulosus fmrfamide receptor 0.001 0.001 0.001
Trichomonas vaginalis ran, putative 0.0039 0.053 0.3355
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0048 0.0687 0.0687
Echinococcus multilocularis serotonin receptor 0.001 0.001 0.001
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus multilocularis tar DNA binding protein 0.0092 0.1477 0.1477
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0569 1 1
Brugia malayi Dopamine receptor protein 1 0.001 0.001 0.0006
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.001 0.001
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Echinococcus granulosus smad 0.001 0.0008 0.0008
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.001 0.001
Toxoplasma gondii PAN domain-containing protein 0.0029 0.034 0.0426
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0097 0.1562 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0092 0.1477 0.1469
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0029 0.034 0.0426
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0053 0.0782 0.0774
Brugia malayi Melatonin receptor type 1A 0.001 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0332
Toxoplasma gondii PAN domain-containing protein 0.0029 0.034 0.0426
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0039 0.053 0.6744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Trypanosoma brucei importin beta-1 subunit, putative 0.0053 0.0782 0.4975
Entamoeba histolytica hypothetical protein 0.0017 0.014 0.0904
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.1562 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus granulosus sex peptide receptor 0.001 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1511 0.1511
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0011 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Entamoeba histolytica hypothetical protein 0.0017 0.014 0.0904
Onchocerca volvulus 0.0029 0.034 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0147 0.2464 0.2458
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus multilocularis importin subunit beta 1 0.0053 0.0782 0.0782
Trypanosoma brucei poly(adp-ribose) polymerase 0.005 0.0726 0.462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Entamoeba histolytica hypothetical protein 0.0017 0.014 0.0904
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0332
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0012 0.0042 0.0061
Loa Loa (eye worm) TAR-binding protein 0.0092 0.1477 0.1469
Echinococcus granulosus g protein coupled receptor 0.001 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0097 0.1562 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.001 0.001
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Leishmania major GTP-binding protein, putative 0.0039 0.053 0.3355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1511 0.1511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1511 0.1511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0061
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.001 0.001
Brugia malayi GnHR receptor homolog 0.001 0.001 0.0006
Loa Loa (eye worm) RNA binding protein 0.0092 0.1477 0.1469
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0039 0.053 0.0522
Brugia malayi hypothetical protein 0.001 0.001 0.0006
Schistosoma mansoni amine GPCR 0.001 0.001 0.001
Brugia malayi Bromodomain containing protein 0.0037 0.0485 0.188
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0332
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni smad1 5 8 and 0.001 0.0008 0.0008
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.001 0.001
Toxoplasma gondii exonuclease III APE 0.0012 0.0042 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0147 0.2464 0.2458
Toxoplasma gondii microneme protein MIC17C 0.0029 0.034 0.0426
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.001 0.001
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.001 0.0006
Brugia malayi Dopamine receptor protein 2 0.001 0.001 0.0006
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Toxoplasma gondii hypothetical protein 0.0029 0.034 0.0426
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.2541 0.2535
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Brugia malayi kap beta 3 protein 0.001 0.0009 0.0002
Schistosoma mansoni poly [ADP-ribose] polymerase 0.005 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Brugia malayi follicle stimulating hormone receptor 0.001 0.001 0.0006
Entamoeba histolytica hypothetical protein 0.0016 0.0109 0.0687
Brugia malayi G protein-coupled receptor 0.001 0.001 0.0006
Onchocerca volvulus DNA ligase 3 homolog 0.0012 0.0042 0.0979
Brugia malayi MH2 domain containing protein 0.0147 0.2464 0.9698
Schistosoma mansoni neuropeptide receptor 0.001 0.001 0.001
Brugia malayi neuropeptide F receptor 0.001 0.001 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.005 0.0726 0.0719
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0358 0.6224 0.6224
Echinococcus multilocularis serotonin receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Schistosoma mansoni opsin-like receptor 0.001 0.001 0.001
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.034 0.0332
Toxoplasma gondii PAN/Apple domain-containing protein 0.0029 0.034 0.0426
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0039 0.053 0.3252
Schistosoma mansoni ran 0.0039 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0011 0.0033 0.0033
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0021 0.0204 0.0204
Brugia malayi TAR-binding protein 0.0092 0.1477 0.5798
Echinococcus granulosus g protein coupled receptor 0.001 0.001 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0017 0.014 0.014
Schistosoma mansoni importin beta-1 0.0053 0.0782 0.0782
Entamoeba histolytica hypothetical protein 0.0017 0.014 0.0904
Schistosoma mansoni hypothetical protein 0.0048 0.0687 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.001 0.001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.001 0.001
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.001 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0043 0.0601 0.3719
Echinococcus granulosus poly (ADP ribose) polymerase 0.0014 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.001 0.001
Brugia malayi larval opioid receptor 0.001 0.001 0.0006
Schistosoma mansoni amine GPCR 0.001 0.001 0.001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.001 0.001
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.001 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0012 0.0042 0.0227
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0011 0.0033 0.0153
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0011 0.0033 0.0153
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0011 0.0033 0.0153
Echinococcus granulosus neuropeptide receptor 0.001 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0012 0.0042 0.0061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.001 0.001
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0092 0.1477 0.1477
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Echinococcus multilocularis sex peptide receptor 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0569 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0011 0.0033 0.0153
Onchocerca volvulus 0.0029 0.034 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.001 0.001
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.001 0.001
Loa Loa (eye worm) TYRA-2 protein 0.001 0.001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0332
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.001 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0092 0.1477 0.1477
Echinococcus granulosus fetal alzheimer antigen falz 0.0011 0.0026 0.0026
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0097 0.1562 1
Echinococcus multilocularis g protein coupled receptor 0.001 0.001 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.001 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0687 0.0687
Echinococcus granulosus poly (ADP ribose) polymerase 0.0014 0.0083 0.0083
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0011 0.0033 0.0033
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.001 0.0006
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.001 0.0001
Echinococcus granulosus importin 5 0.001 0.0009 0.0009
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.001 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.001 0.001
Brugia malayi Dopamine receptor 0.001 0.001 0.0006
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.005 0.0726 0.0726
Toxoplasma gondii PAN domain-containing protein 0.0444 0.7769 1
Schistosoma mansoni tar DNA-binding protein 0.0092 0.1477 0.1477
Brugia malayi PAN domain containing protein 0.0029 0.034 0.1309
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.001 0.001
Brugia malayi Bromodomain containing protein 0.0019 0.0164 0.0613
Onchocerca volvulus 0.0029 0.034 1
Echinococcus multilocularis smad 0.001 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0095 0.1526 0.1955
Entamoeba histolytica hypothetical protein 0.0014 0.0083 0.0506
Loa Loa (eye worm) hypothetical protein 0.0048 0.0687 0.0679
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0687 0.2679
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0351 0.0351
Echinococcus multilocularis orexin receptor type 2 0.001 0.001 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0011 0.0033 0.0153
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0043 0.0601 0.3815
Echinococcus granulosus neuropeptide Y receptor 0.001 0.001 0.001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0039 0.053 0.206
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0043 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.001 0.001
Trypanosoma brucei DNA repair protein, putative 0.0012 0.0042 0.0213
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0109 0.0397
Echinococcus granulosus mitogen activated protein kinase 0.0097 0.1562 0.1562
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0097 0.1562 0.2001
Echinococcus granulosus orexin receptor type 2 0.001 0.001 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0012 0.0042 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0202 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.001 0.001
Echinococcus granulosus GPCR family 2 0.0048 0.0687 0.0687
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.001 0.001
Brugia malayi AKH receptor 0.001 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1511 0.1511
Loa Loa (eye worm) importin-beta domain-containing protein 0.001 0.0009 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0153
Plasmodium falciparum importin beta, putative 0.0053 0.0782 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 106.2 nM BindingDB_Patents: IMAP-FP Assay. Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was determined from a 10 point (1:3 serial dilution, 3 uM starting compound concentration) titration curve using the following outlined procedure. To each well of a black Corning 384-well plate (Corning Catalog #3575), 7.5 mL of compound (3333 fold dilution in final assay volume of 25 uL) was dispensed, followed by the addition of 15 uL of kinase buffer (tween containing kinase buffer, Molecular Devices) containing 0.0364 ng/mL (0.833 nM) of phosphorylated active hERK2 enzyme. Following a 15 minute compound & enzyme incubation, each reaction was initiated by the addition of 10 uL kinase buffer containing 2.45 uM ERK2 IMAP substrate peptides (2.25 uM-unlabeled IPTTPITTTYFFFK-COOH and 200 nM-labeled IPTTPITTTYFFFK-5FAM (5-carboxyfluorescein)-COOH), and 75 uM ATP. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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