TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 259.175 | Formula: C12H16Cl2N2
H donors: 1 H acceptors: 0 LogP: 3.67 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CC1CC/C(=N\c2cc(C)ccc2Cl)/N1.Cl
InChi: 1S/C12H15ClN2.ClH/c1-8-3-5-10(13)11(7-8)15-12-6-4-9(2)14-12;/h3,5,7,9H,4,6H2,1-2H3,(H,14,15);1H
InChiKey: WGYAIQFBHIKUMU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0015
Echinococcus granulosus	histone acetyltransferase KAT2B	0.012	0.023	0.0978
Echinococcus multilocularis	lamin dm0	0.0023	0.0015	0.0063
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0178	0.0357	0.1518
Brugia malayi	RNA binding protein	0.0054	0.0083	0.0791
Brugia malayi	cathepsin L precursor	0.0018	0.0004	0.0034
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0031	0.0298
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0018	0.0004	0.0034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Onchocerca volvulus		0.0049	0.0072	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0004	0.0015
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0025	0.002	0.0046
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0004	0.0209
Brugia malayi	hypothetical protein	0.005	0.0073	0.0697
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.1078	0.2349	0.6481
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0018	0.0004	0.0209
Plasmodium falciparum	plasmepsin II	0.1078	0.2349	0.6481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0004	0.0209
Trypanosoma cruzi	cruzipain precursor, putative	0.0049	0.0072	0.0879
Toxoplasma gondii	aspartyl protease ASP3	0.1654	0.3623	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0004	0.0015
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0038	0.0048	0.0048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0411	0.0873	0.3716
Loa Loa (eye worm)	reprolysin	0.0038	0.0048	0.0203
Schistosoma mansoni	memapsin-2 (A01 family)	0.0411	0.0873	0.0873
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0036	0.0044	0.0523
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0031	0.0031
Echinococcus multilocularis	adam	0.005	0.0073	0.0313
Loa Loa (eye worm)	6-phosphofructokinase	0.0093	0.0169	0.0719
Plasmodium vivax	aspartyl proteinase, putative	0.0411	0.0873	0.2402
Brugia malayi	Pre-SET motif family protein	0.0178	0.0357	0.3384
Echinococcus granulosus	histone lysine methyltransferase setb	0.0025	0.002	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0189
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0018	0.0004	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0031	0.0134
Schistosoma mansoni	lamin	0.0023	0.0015	0.0015
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0411	0.0873	0.8283
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0004	0.0034
Brugia malayi	6-phosphofructokinase	0.0093	0.0169	0.1603
Toxoplasma gondii	phosphofructokinase PFKII	0.0025	0.0019	0.0043
Giardia lamblia	Cathepsin B precursor	0.0127	0.0245	1
Schistosoma mansoni	thyroid hormone receptor	0.0116	0.022	0.022
Brugia malayi	ADAMTS-like protease	0.0022	0.0013	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Brugia malayi	fibroinase precursor	0.0018	0.0004	0.0034
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0049	0.0072	0.019
Loa Loa (eye worm)	hypothetical protein	0.0025	0.002	0.0086
Schistosoma mansoni	cathepsin C	0.0018	0.0004	0.0004
Brugia malayi	6-phosphofructokinase	0.0093	0.0169	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0004	0.0015
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.0169	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0004	0.0209
Brugia malayi	hypothetical protein	0.0411	0.0873	0.8283
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0127	0.0245	0.1044
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0072	0.0879
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0127	0.0245	0.3093
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0127	0.0245	1
Echinococcus granulosus	cathepsin l1	0.0036	0.0044	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0018	0.0004	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0004	0.0015
Schistosoma mansoni	hypothetical protein	0.0107	0.0201	0.0201
Plasmodium vivax	vivapain-2	0.0049	0.0072	0.019
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0004	0.0034
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0022	0.0013	0.0122
Echinococcus granulosus	tar DNA binding protein	0.0054	0.0083	0.0355
Toxoplasma gondii	cathepsin B	0.0127	0.0245	0.0668
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0025	0.0019	0.065
Brugia malayi	acetyltransferase, GNAT family protein	0.0124	0.0237	0.2252
Onchocerca volvulus		0.0036	0.0044	0.047
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0004	0.0004
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0116	0.022	0.0939
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0023	0.0015	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0072	0.0879
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0004	0.0034
Onchocerca volvulus		0.0025	0.002	0.0191
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0025	0.002	0.0086
Schistosoma mansoni	hypothetical protein	0.0145	0.0284	0.0284
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0049	0.0072	0.019
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0004	0.0209
Plasmodium falciparum	plasmepsin IX	0.1654	0.3623	1
Loa Loa (eye worm)	hypothetical protein	0.0411	0.0873	0.3716
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0124	0.0237	0.101
Brugia malayi	angiogenesis inhibito	0.0022	0.0013	0.0122
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0036	0.0044	0.0113
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0018	0.0004	0.0004
Onchocerca volvulus	Cathepsin F homolog	0.0049	0.0072	0.079
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0018	0.0004	0.0034
Brugia malayi	aspartic protease BmAsp-1, identical	0.0411	0.0873	0.8283
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0004	0.0015
Plasmodium vivax	aspartyl protease, putative	0.1654	0.3623	1
Loa Loa (eye worm)	hypothetical protein	0.0493	0.1054	0.4486
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Plasmodium falciparum	plasmepsin VIII, putative	0.0411	0.0873	0.2402
Echinococcus multilocularis	musashi	0.0023	0.0015	0.0063
Plasmodium falciparum	plasmepsin VI	0.1078	0.2349	0.6481
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.0031	0.0357
Schistosoma mansoni	cathepsin D (A01 family)	0.4222	0.9302	0.9302
Plasmodium falciparum	plasmepsin X	0.1654	0.3623	1
Loa Loa (eye worm)	hypothetical protein	0.0371	0.0785	0.3341
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0031	0.1858
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0072	0.0686
Brugia malayi	cathepsin L-like cysteine proteinase	0.0018	0.0004	0.0034
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Plasmodium vivax	6-phosphofructokinase, putative	0.0025	0.0019	0.0043
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0025	0.0019	0.1139
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0025	0.0019	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0083	0.0083
Brugia malayi	cathepsin L-like precursor	0.0036	0.0044	0.0421
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.0169	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0004	0.0015
Toxoplasma gondii	aspartyl protease ASP1	0.1078	0.2349	0.6481
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0036	0.0044	0.0113
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.1078	0.2349	1
Onchocerca volvulus		0.0049	0.0072	0.079
Onchocerca volvulus		0.0023	0.0015	0.0129
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0044	0.0044
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.0031	0.0357
Schistosoma mansoni	cathepsin B (C01 family)	0.0018	0.0004	0.0004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0072	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0044	0.0189
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0031	0.0298
Echinococcus granulosus	cathepsin L	0.0031	0.0031	0.0134
Entamoeba histolytica	cysteine proteinase 1, putative	0.0031	0.0031	0.1858
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0093	0.0169	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0054	0.0083	0.0355
Plasmodium vivax	SET domain protein, putative	0.0025	0.002	0.0046
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0025	0.0019	0.0043
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0025	0.0019	0.0043
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0072	0.0686
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0124	0.0237	0.0237
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0049	0.0072	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0031	0.0134
Loa Loa (eye worm)	cathepsin B	0.0127	0.0245	0.1044
Plasmodium vivax	vivapain-3	0.0031	0.0031	0.0077
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0004	0.0034
Brugia malayi	hypothetical protein	0.0411	0.0873	0.8283
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0072	0.0686
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0044	0.0421
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0025	0.002	0.002
Echinococcus multilocularis	cathepsin b	0.0371	0.0785	0.3341
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0072	0.4276
Loa Loa (eye worm)	aspartyl protease 6	0.0411	0.0873	0.3716
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0072	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Plasmodium falciparum	plasmepsin IV	0.1078	0.2349	0.6481
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0371	0.0785	0.0785
Plasmodium falciparum	plasmepsin VII	0.0411	0.0873	0.2402
Echinococcus granulosus	expressed protein	0.0319	0.0668	0.2845
Brugia malayi	Pre-SET motif family protein	0.0025	0.002	0.0191
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0072	0.0879
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0411	0.0873	0.2402
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.1078	0.2349	0.2349
Onchocerca volvulus		0.0049	0.0072	0.079
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0014	0.0059
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0036	0.0044	0.0113
Plasmodium vivax	aspartyl protease, putative	0.1654	0.3623	1
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0044	0.2628
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0049	0.0072	0.0308
Brugia malayi	RNA recognition motif domain containing protein	0.0054	0.0083	0.0791
Echinococcus multilocularis	cathepsin b	0.0371	0.0785	0.3341
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0371	0.0785	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0371	0.0785	0.0785
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0038	0.0048	0.0203
Plasmodium falciparum	histone acetyltransferase GCN5	0.0033	0.0038	0.0094
Brugia malayi	phosphofructokinase	0.0093	0.0169	0.1603
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0004	0.0015
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0004	0.0004
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Echinococcus multilocularis	cathepsin L	0.0018	0.0004	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0015
Echinococcus multilocularis	cathepsin L	0.0031	0.0031	0.0134
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0038	0.0048	0.0203
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0004	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0018	0.0004	0.0015
Loa Loa (eye worm)	ctsf protein	0.0049	0.0072	0.0308
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0025	0.002	0.0086
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0107	0.0201	0.0857
Loa Loa (eye worm)	intermediate filament protein	0.0023	0.0015	0.0063
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0049	0.0072	0.0308
Brugia malayi	Intermediate filament tail domain containing protein	0.0023	0.0015	0.014
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0031	0.0031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Onchocerca volvulus		0.0049	0.0072	0.079
Schistosoma mansoni	lamin	0.0023	0.0015	0.0015
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.005	0.0073	0.0073
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0072	0.0879
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0018	0.0004	0.0015
Giardia lamblia	Histone acetyltransferase GCN5	0.0033	0.0038	0.1408
Schistosoma mansoni	hypothetical protein	0.0145	0.0284	0.0284
Loa Loa (eye worm)	phosphofructokinase	0.0093	0.0169	0.0719
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0371	0.0785	0.0785
Entamoeba histolytica	acetyltransferase, GNAT family	0.0033	0.0038	0.2223
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Echinococcus granulosus	intermediate filament protein	0.0023	0.0015	0.0063
Trypanosoma brucei	RNA helicase, putative	0.0177	0.0355	1
Entamoeba histolytica	phosphofructokinase, putative	0.0093	0.0169	1
Plasmodium falciparum	plasmepsin V	0.0411	0.0873	0.2402
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0093	0.0169	0.4257
Trichomonas vaginalis	phosphofructokinase, putative	0.0025	0.0019	0.0082
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0004	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Brugia malayi	aspartic protease BmAsp-2, identical	0.0411	0.0873	0.8283
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Leishmania major	ATP-dependent phosphofructokinase	0.0093	0.0169	0.5592
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0044	0.0189
Echinococcus multilocularis	6 phosphofructokinase	0.0093	0.0169	0.0719
Echinococcus granulosus	lamin dm0	0.0023	0.0015	0.0063
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Brugia malayi	intermediate filament protein	0.0023	0.0015	0.014
Onchocerca volvulus		0.0049	0.0072	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.0072	0.0686
Giardia lamblia	Cathepsin B precursor	0.0127	0.0245	1
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0072	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Onchocerca volvulus		0.0411	0.0873	1
Loa Loa (eye worm)	cysteine protease	0.0049	0.0072	0.0308
Echinococcus granulosus	geminin	0.0145	0.0284	0.1207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0018	0.0004	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Entamoeba histolytica	cysteine protease, putative	0.0049	0.0072	0.4276
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0018	0.0004	0.0209
Echinococcus granulosus	6 phosphofructokinase	0.0093	0.0169	0.0719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0083	0.0083
Plasmodium vivax	plasmepsin IV, putative	0.1078	0.2349	0.6481
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0031	0.0031	0.0077
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0018	0.0004	0.0034
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0044	0.0421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Loa Loa (eye worm)	RNA binding protein	0.0054	0.0083	0.0355
Loa Loa (eye worm)	6-phosphofructokinase	0.0093	0.0169	0.0719
Plasmodium vivax	aspartyl protease, putative	0.0411	0.0873	0.2402
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0025	0.002	0.002
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0072	0.079
Schistosoma mansoni	6-phosphofructokinase	0.0093	0.0169	0.0169
Echinococcus granulosus	cathepsin L	0.0018	0.0004	0.0015
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0031	0.1858
Onchocerca volvulus		0.0023	0.0015	0.0129
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0004	0.0015
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0072	0.0308
Echinococcus multilocularis	tar DNA binding protein	0.0054	0.0083	0.0355
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.1078	0.2349	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0025	0.0019	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0049	0.0072	0.019
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0018	0.0004	0.0015
Brugia malayi	Pepsin A precursor	0.0411	0.0873	0.8283
Toxoplasma gondii	aspartyl protease	0.0411	0.0873	0.2402
Mycobacterium ulcerans	6-phosphofructokinase	0.0093	0.0169	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0025	0.002	0.002
Plasmodium vivax	aspartyl proteinase, putative	0.1078	0.2349	0.6481
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0107	0.0201	0.0857
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0018	0.0004	0.0015
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Schistosoma mansoni	6-phosphofructokinase	0.0093	0.0169	0.0169
Trichomonas vaginalis	phosphofructokinase, putative	0.0025	0.0019	0.0082
Loa Loa (eye worm)	fibroinase	0.0049	0.0072	0.0308
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308
Loa Loa (eye worm)	hypothetical protein	0.1078	0.2349	1
Echinococcus granulosus	cathepsin b	0.0371	0.0785	0.3341
Schistosoma mansoni	intermediate filament proteins	0.0023	0.0015	0.0015
Plasmodium vivax	vivapain-1	0.0031	0.0031	0.0077
Trichomonas vaginalis	phosphofructokinase, putative	0.0025	0.0019	0.0082
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0093	0.0169	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0018	0.0004	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0004	0.0015
Trichomonas vaginalis	phosphofructokinase, putative	0.0025	0.0019	0.0082
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0018	0.0004	0.0004
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0036	0.0044	0.0188
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Trichomonas vaginalis	phosphofructokinase, putative	0.0025	0.0019	0.0082
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0371	0.0785	0.0785
Echinococcus granulosus	cysteine protease	0.0031	0.0031	0.0134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0004	0.0015
Schistosoma mansoni	cathepsin S (C01 family)	0.0018	0.0004	0.0004
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0049	0.0072	0.0308
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0093	0.0169	0.5
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0004	0.0209
Brugia malayi	cathepsin B-like cysteine proteinase	0.0371	0.0785	0.7447
Echinococcus granulosus	cathepsin b	0.0371	0.0785	0.3341
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0004	0.0209
Giardia lamblia	Cathepsin B precursor	0.0127	0.0245	1
Loa Loa (eye worm)	acetyltransferase	0.0124	0.0237	0.101
Brugia malayi	Reprolysin	0.0022	0.0013	0.0122
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0031	0.1858
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0004	0.0015
Trypanosoma cruzi	cysteine protease, putative	0.0031	0.0031	0.0357
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0072	0.0072
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0072	0.079
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0025	0.0019	0.0043
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.0169	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0072	0.0308
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0093	0.0169	0.2117
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0072	0.0072
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Entamoeba histolytica	hypothetical protein	0.0018	0.0004	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0055
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0031	0.0031	0.0357
Echinococcus granulosus	cathepsin l1	0.0049	0.0072	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0018	0.0004	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0411	0.0873	0.3716
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0072	0.0308
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0072	0.4276
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0411	0.0873	0.0873
Echinococcus multilocularis	lamin	0.0023	0.0015	0.0063
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0072	0.0308
Entamoeba histolytica	cysteine proteinase 2	0.0031	0.0031	0.1858
Schistosoma mansoni	thyroid hormone receptor	0.0116	0.022	0.022
Echinococcus granulosus	lamin	0.0023	0.0015	0.0063
Toxoplasma gondii	cathepsin CPL	0.0049	0.0072	0.019
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0072	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0072	0.0308
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.1078	0.2349	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0015	0.0063
Plasmodium vivax	plasmepsin V, putative	0.0411	0.0873	0.2402
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0083	0.0083
Toxoplasma gondii	6-phosphofructokinase	0.0025	0.0019	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0018	0.0004	0.0015
Echinococcus granulosus	adam	0.005	0.0073	0.0313
Echinococcus multilocularis	cysteine protease	0.0049	0.0072	0.0308
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0036	0.0044	0.0188
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.1078	0.2349	1
Plasmodium falciparum	plasmepsin I	0.1078	0.2349	0.6481
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.0044	0.0421
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Onchocerca volvulus		0.0411	0.0873	1
Brugia malayi	small heat shock protein	0.0493	0.1054	1
Onchocerca volvulus		0.0202	0.0411	0.4685
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0004	0.0004
Plasmodium vivax	unspecified product	0.0031	0.0031	0.0077
Onchocerca volvulus		0.0049	0.0072	0.079
Schistosoma mansoni	cathepsin D (A01 family)	0.4222	0.9302	0.9302
Plasmodium vivax	vivapain-2	0.0049	0.0072	0.019
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0031	0.1858
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0889	0.1931	0.1931
Trichomonas vaginalis	phosphofructokinase, putative	0.0025	0.0019	0.0082
Loa Loa (eye worm)	TAR-binding protein	0.0054	0.0083	0.0355
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0083	0.0083
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0018	0.0004	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0072	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0015
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0031	0.0357
Echinococcus granulosus	cathepsin L cysteine protease	0.0031	0.0031	0.0134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0072	0.1264
Echinococcus multilocularis	expressed protein	0.0319	0.0668	0.2845
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0025	0.0019	0.0082
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0072	0.0686
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0036	0.0044	0.0188
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0127	0.0245	0.0245
Trichomonas vaginalis	set domain proteins, putative	0.0202	0.0411	0.1749
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0189
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0083	0.0083
Onchocerca volvulus		0.0049	0.0072	0.079
Echinococcus multilocularis	cysteine protease	0.0049	0.0072	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0015
Brugia malayi	TAR-binding protein	0.0054	0.0083	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0015
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0031	0.1858
Entamoeba histolytica	phosphofructokinase, putative	0.0093	0.0169	1
Entamoeba histolytica	phosphofructokinase, putative	0.0093	0.0169	1
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0038	0.0048	0.0048
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0004	0.0004
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.0169	0.0719
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0127	0.0245	0.6616
Plasmodium vivax	6-phosphofructokinase, putative	0.0025	0.0019	0.0043
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0025	0.002	0.002
Plasmodium falciparum	plasmepsin III	0.0411	0.0873	0.2402
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0004	0.0004
Echinococcus multilocularis	geminin	0.0145	0.0284	0.1207
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0025	0.0018	0.0077
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0072	0.0308

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)		Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting	ChEMBL.	25521963
Ki (binding)		Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 mins	ChEMBL.	25521963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3408281

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 2015478