Detailed information for compound 20576

Basic information

Technical information
  • TDR Targets ID: 20576
  • Name: 3-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl] propanoic acid
  • MW: 369.434 | Formula: C20H19NO4S
  • H donors: 1 H acceptors: 3 LogP: 4.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1sc(nc1c1ccc(cc1)OC)CCC(=O)O
  • InChi: 1S/C20H19NO4S/c1-24-15-7-3-13(4-8-15)19-20(14-5-9-16(25-2)10-6-14)26-17(21-19)11-12-18(22)23/h3-10H,11-12H2,1-2H3,(H,22,23)
  • InChiKey: SGHNJMBVVMKJIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]propanoic acid
  • 3-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]propanoic acid
  • 3-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Leishmania major cathepsin L-like protease 0.0018 0.0161 0.0331
Leishmania major cathepsin L-like protease 0.0018 0.0161 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Echinococcus granulosus Tubulin beta 2C chain 0.009 0.4855 0.4855
Brugia malayi Tubulin beta chain 0.0018 0.0138 0.0284
Trypanosoma brucei epsilon tubulin 0.0041 0.1657 0.3413
Echinococcus multilocularis tubulin epsilon chain 0.0041 0.1657 0.1657
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Schistosoma mansoni hypothetical protein 0.0169 1 1
Loa Loa (eye worm) tubulin alpha chain 0.005 0.2214 0.4561
Trypanosoma cruzi tubulin delta chain 0.0018 0.0138 0.0284
Brugia malayi Tubulin gamma chain 0.0041 0.1657 0.3413
Leishmania major beta tubulin 0.009 0.4855 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.005 0.2214 0.4561
Trypanosoma brucei epsilon tubulin 0.0041 0.1657 0.3413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Brugia malayi Cathepsin L-like precursor 0.0018 0.0161 0.0331
Leishmania major epsilon tubulin, putative 0.0041 0.1657 0.3413
Leishmania major beta tubulin 0.009 0.4855 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Leishmania major beta tubulin 0.009 0.4855 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.2214 0.4402
Leishmania major gamma-tubulin 0.0041 0.1657 0.3413
Trichomonas vaginalis tubulin gamma chain, putative 0.0041 0.1657 0.3221
Loa Loa (eye worm) tubulin beta-1 chain 0.009 0.4855 1
Echinococcus granulosus beta tubulin 0.009 0.4855 0.4855
Schistosoma mansoni tubulin subunit beta 0.009 0.4855 0.4855
Loa Loa (eye worm) hypothetical protein 0.0032 0.1048 0.2159
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0161 0.0331
Schistosoma mansoni tubulin subunit beta 0.009 0.4855 0.4855
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0161 0.0161
Leishmania major beta tubulin 0.009 0.4855 1
Echinococcus granulosus tubulin alpha chain 0.005 0.2214 0.2214
Trypanosoma cruzi epsilon tubulin, putative 0.0041 0.1657 0.3413
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0161 0.0331
Toxoplasma gondii cathepsin CPL 0.0018 0.0161 0.0331
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0018 0.0138 0.0284
Plasmodium falciparum tubulin delta chain, putative 0.0018 0.0138 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Leishmania major beta tubulin 0.009 0.4855 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Echinococcus granulosus peroxisome assembly protein 26 0.005 0.2214 0.2214
Onchocerca volvulus 0.0023 0.0491 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.2214 0.4402
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.0491 0.0749
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.2214 0.4402
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Toxoplasma gondii beta-tubulin, putative 0.009 0.4855 1
Echinococcus granulosus tubulin alpha 3 chain 0.005 0.2214 0.2214
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.2214 0.4402
Trypanosoma brucei beta tubulin 0.009 0.4855 1
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.2214 0.4402
Loa Loa (eye worm) tubulin beta chain 0.0018 0.0138 0.0284
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0161 0.0331
Brugia malayi Tubulin alpha-2 chain 0.005 0.2214 0.4561
Echinococcus multilocularis tubulin beta 1 chain 0.009 0.4855 0.4855
Leishmania major beta tubulin 0.009 0.4855 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0161 0.0331
Trypanosoma brucei zeta tubulin 0.0018 0.0138 0.0284
Schistosoma mansoni tubulin subunit alpha 0.005 0.2214 0.2214
Echinococcus granulosus Tubulin beta 2C chain 0.009 0.4855 0.4855
Echinococcus granulosus tubulin alpha 1C chain 0.005 0.2214 0.2214
Schistosoma mansoni tubulin subunit epsilon 0.0041 0.1657 0.1657
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.2214 0.4402
Trypanosoma cruzi zeta tubulin, putative 0.0018 0.0138 0.0284
Loa Loa (eye worm) tubulin alpha chain 0.005 0.2214 0.4561
Echinococcus multilocularis tubulin, beta 4A class IVa 0.009 0.4855 0.4855
Entamoeba histolytica tubulin alpha chain, putative 0.005 0.2214 0.4375
Echinococcus multilocularis tubulin alpha chain 0.005 0.2214 0.2214
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0161 0.0048
Leishmania major cathepsin L-like protease 0.0018 0.0161 0.0331
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0161 0.0161
Trypanosoma brucei tubulin delta chain 0.0018 0.0138 0.0284
Leishmania major beta tubulin 0.009 0.4855 1
Echinococcus multilocularis peroxisome assembly protein 26 0.005 0.2214 0.2214
Mycobacterium ulcerans cell division protein FtsZ 0.0018 0.0138 0.5
Echinococcus multilocularis tubulin alpha chain 0.005 0.2214 0.2214
Trypanosoma cruzi tubulin gamma chain 0.0041 0.1657 0.3413
Plasmodium vivax tubulin epsilon chain, putative 0.0041 0.1657 0.3413
Trichomonas vaginalis tubulin gamma chain, putative 0.0041 0.1657 0.3221
Echinococcus multilocularis Tubulin alpha 1 chain 0.005 0.2214 0.2214
Trypanosoma cruzi zeta tubulin, putative 0.0018 0.0138 0.0284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Toxoplasma gondii beta tubulin 0.009 0.4855 1
Giardia lamblia Beta tubulin 0.009 0.4855 1
Loa Loa (eye worm) alpha-tubulin 0.005 0.2214 0.4561
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0161 0.0331
Leishmania major beta tubulin 0.009 0.4855 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Schistosoma mansoni tubulin subunit alpha 0.005 0.2214 0.2214
Echinococcus multilocularis cysteine protease 0.0018 0.0161 0.0161
Entamoeba histolytica tubulin alpha-1 chain 0.005 0.2214 0.4375
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0032 0.1048 0.2159
Echinococcus granulosus tubulin delta chain 0.0018 0.0138 0.0138
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.2214 0.4402
Loa Loa (eye worm) tubulin beta chain 0.009 0.4855 1
Schistosoma mansoni alpha tubulin 0.005 0.2214 0.2214
Giardia lamblia Beta tubulin 0.009 0.4855 1
Echinococcus granulosus tubulin epsilon chain 0.0041 0.1657 0.1657
Echinococcus granulosus tubulin subunit beta 0.009 0.4855 0.4855
Echinococcus granulosus tubulin gamma 1 chain 0.0041 0.1657 0.1657
Echinococcus multilocularis tubulin alpha 0.0041 0.1657 0.1657
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.2214 0.4402
Echinococcus granulosus Tubulin beta 2C chain 0.009 0.4855 0.4855
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0161 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Trichomonas vaginalis tubulin beta chain, putative 0.009 0.4855 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0161 0.0048
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0161 0.0331
Plasmodium falciparum alpha tubulin 2 0.005 0.2214 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Echinococcus multilocularis tubulin alpha 3 chain 0.005 0.2214 0.2214
Leishmania major beta tubulin 0.009 0.4855 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.3501 0.7211
Trypanosoma brucei alpha tubulin, putative 0.0023 0.0491 0.1012
Echinococcus multilocularis beta tubulin 0.009 0.4855 0.4855
Brugia malayi Tubulin beta-1 chain 0.009 0.4855 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Plasmodium vivax vivapain-2 0.0018 0.0161 0.0331
Echinococcus granulosus tubulin alpha 0.0041 0.1657 0.1657
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Brugia malayi Cathepsin L-like precursor 0.0018 0.0161 0.0331
Brugia malayi beta-tubulin, identical 0.009 0.4855 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Loa Loa (eye worm) tubulin gamma chain 0.0041 0.1657 0.3413
Trypanosoma brucei beta tubulin 0.009 0.4855 1
Echinococcus multilocularis tubulin alpha chain 0.005 0.2214 0.2214
Schistosoma mansoni tubulin subunit beta 0.009 0.4855 0.4855
Loa Loa (eye worm) BEN-1 protein 0.009 0.4855 1
Trypanosoma brucei epsilon tubulin 0.0041 0.1657 0.3413
Brugia malayi Cathepsin L-like precursor 0.0018 0.0161 0.0331
Brugia malayi Tubulin alpha chain 0.005 0.2214 0.4561
Brugia malayi Tubulin alpha-2 chain 0.005 0.2214 0.4561
Schistosoma mansoni alpha tubulin 0.005 0.2214 0.2214
Trypanosoma brucei beta tubulin 0.009 0.4855 1
Toxoplasma gondii alpha-tubulin I, putative 0.005 0.2214 0.4561
Echinococcus multilocularis Tubulin beta 2C chain 0.009 0.4855 0.4855
Schistosoma mansoni hypothetical protein 0.0169 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0161 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Echinococcus granulosus Tubulin alpha 1 chain 0.005 0.2214 0.2214
Loa Loa (eye worm) tubulin alpha-3 chain 0.0026 0.0695 0.1431
Loa Loa (eye worm) hypothetical protein 0.005 0.2214 0.4561
Leishmania major cathepsin L-like protease 0.0069 0.3501 0.7211
Echinococcus granulosus Tubulin alpha 1 chain 0.005 0.2214 0.2214
Giardia lamblia Beta tubulin 0.009 0.4855 1
Trichomonas vaginalis tubulin gamma chain, putative 0.009 0.4855 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0161 0.0161
Trichomonas vaginalis tubulin, putative 0.0023 0.0491 0.0749
Schistosoma mansoni tubulin subunit beta 0.009 0.4855 0.4855
Toxoplasma gondii alpha tubulin TUBA1 0.005 0.2214 0.4561
Loa Loa (eye worm) fibroinase 0.0018 0.0161 0.0331
Echinococcus multilocularis tubulin alpha 1C chain 0.005 0.2214 0.2214
Giardia lamblia Alpha-tubulin 0.005 0.2214 0.4402
Echinococcus granulosus tubulin subunit TubB 0.005 0.2214 0.2214
Leishmania major beta tubulin 0.009 0.4855 1
Schistosoma mansoni tubulin subunit beta 0.009 0.4855 0.4855
Plasmodium vivax vivapain-2 0.0018 0.0161 0.0331
Echinococcus multilocularis tubulin alpha 3 chain 0.005 0.2214 0.2214
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0161 0.0331
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Plasmodium vivax tubulin gamma chain, putative 0.0041 0.1657 0.3413
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.2532 0.5215
Echinococcus multilocularis tubulin delta chain 0.0018 0.0138 0.0138
Echinococcus granulosus Tubulin beta 2C chain 0.009 0.4855 0.4855
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Leishmania major cathepsin L-like protease 0.0069 0.3501 0.7211
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.3501 0.7211
Trichomonas vaginalis tubulin alpha chain, putative 0.009 0.4855 1
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Leishmania major cathepsin L-like protease 0.0069 0.3501 0.7211
Trypanosoma brucei tubulin gamma chain 0.0041 0.1657 0.3413
Loa Loa (eye worm) ctsf protein 0.0018 0.0161 0.0331
Loa Loa (eye worm) tubulin beta-2A chain 0.009 0.4855 1
Echinococcus granulosus Tubulin alpha 1 chain 0.005 0.2214 0.2214
Entamoeba histolytica tubulin family protein 0.009 0.4855 1
Echinococcus granulosus tubulin beta 4A class IVa 0.009 0.4855 0.4855
Treponema pallidum cell division protein FtsZ 0.0018 0.0138 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Brugia malayi tubulin alpha-2 chain 0.005 0.2214 0.4561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Plasmodium falciparum tubulin beta chain 0.009 0.4855 1
Trypanosoma brucei alpha tubulin 0.005 0.2214 0.4561
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0026 0.0695 0.1181
Loa Loa (eye worm) tubulin beta-4 chain 0.009 0.4855 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0161 0.0161
Brugia malayi Cell division protein ftsZ 0.0018 0.0138 0.0284
Trypanosoma brucei beta tubulin 0.0041 0.1657 0.3413
Loa Loa (eye worm) BEN-1 protein 0.009 0.4855 1
Schistosoma mansoni tubulin subunit gamma 0.0041 0.1657 0.1657
Schistosoma mansoni tubulin subunit beta 0.0018 0.0138 0.0138
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0018 0.0138 0.0284
Echinococcus granulosus tubulin beta 1 chain 0.009 0.4855 0.4855
Echinococcus multilocularis Tubulin beta 2C chain 0.009 0.4855 0.4855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.0491 0.0749
Echinococcus granulosus tubulin alpha chain 0.005 0.2214 0.2214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Brugia malayi Tubulin alpha chain 0.0018 0.0138 0.0284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Giardia lamblia Gamma tubulin 0.0041 0.1657 0.3221
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0023 0.0491 0.0749
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0041 0.1657 0.3413
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0161 0.0331
Trichomonas vaginalis tubulin epsilon chain, putative 0.009 0.4855 1
Leishmania major beta tubulin 0.009 0.4855 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0161 0.0331
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.0491 0.0749
Plasmodium falciparum tubulin gamma chain 0.0041 0.1657 0.3413
Leishmania major beta tubulin 0.009 0.4855 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0032 0.1048 0.193
Echinococcus granulosus tubulin alpha chain 0.005 0.2214 0.2214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Schistosoma mansoni alpha tubulin 0.005 0.2214 0.2214
Trichomonas vaginalis tubulin, putative 0.0023 0.0491 0.0749
Brugia malayi Tubulin beta chain 0.0023 0.0491 0.1012
Giardia lamblia Alpha-tubulin 0.005 0.2214 0.4402
Leishmania major beta tubulin 0.009 0.4855 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0041 0.1657 0.3413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Trichomonas vaginalis tubulin alpha chain, putative 0.0041 0.1657 0.3221
Leishmania major beta tubulin 0.009 0.4855 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.3108 0.6402
Leishmania major cathepsin L-like protease 0.0018 0.0161 0.0331
Echinococcus granulosus alpha tubulin 0.005 0.2214 0.2214
Trypanosoma cruzi tubulin delta chain 0.0018 0.0138 0.0284
Echinococcus multilocularis Tubulin beta 2C chain 0.009 0.4855 0.4855
Echinococcus multilocularis tubulin alpha 1C chain 0.005 0.2214 0.2214
Echinococcus multilocularis geminin 0.0169 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0041 0.1657 0.3413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Loa Loa (eye worm) tubulin alpha 2 0.0032 0.1048 0.2159
Schistosoma mansoni tubulin subunit alpha 0.0018 0.0138 0.0138
Echinococcus multilocularis Tubulin alpha 1 chain 0.005 0.2214 0.2214
Leishmania major zeta tubulin, putative 0.0018 0.0138 0.0284
Loa Loa (eye worm) tubulin alpha 2 0.0032 0.1048 0.2159
Echinococcus multilocularis Tubulin alpha 1 chain 0.005 0.2214 0.2214
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Brugia malayi Cathepsin L-like precursor 0.0018 0.0161 0.0331
Echinococcus multilocularis Tubulin beta 2C chain 0.009 0.4855 0.4855
Toxoplasma gondii beta-1 tubulin, putative 0.009 0.4855 1
Entamoeba histolytica tubulin family protein 0.009 0.4855 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.3501 0.7211
Loa Loa (eye worm) beta-tubulin 0.009 0.4855 1
Echinococcus granulosus tubulin alpha 3 chain 0.005 0.2214 0.2214
Plasmodium vivax tubulin beta chain, putative 0.009 0.4855 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Echinococcus multilocularis tubulin subunit TubB 0.005 0.2214 0.2214
Loa Loa (eye worm) alpha-tubulin 0.005 0.2214 0.4561
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.005 0.2214 0.4402
Schistosoma mansoni tubulin subunit alpha 0.005 0.2214 0.2214
Plasmodium vivax tubulin alpha chain, putative 0.005 0.2214 0.4561
Echinococcus multilocularis beta tubulin 0.009 0.4855 0.4855
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Echinococcus granulosus tubulin alpha chain 0.005 0.2214 0.2214
Echinococcus granulosus Tubulin beta 2C chain 0.009 0.4855 0.4855
Trypanosoma brucei alpha tubulin 0.005 0.2214 0.4561
Trypanosoma cruzi beta tubulin, putative 0.009 0.4855 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0161 0.0331
Echinococcus multilocularis tubulin subunit beta 0.009 0.4855 0.4855
Echinococcus multilocularis hypothetical protein 0.005 0.2214 0.2214
Loa Loa (eye worm) hypothetical protein 0.0026 0.0695 0.1431
Echinococcus multilocularis tubulin alpha chain 0.005 0.2214 0.2214
Leishmania major delta tubulin, putative 0.0018 0.0138 0.0284
Leishmania major beta tubulin 0.009 0.4855 1
Entamoeba histolytica tubulin gamma chain 0.0041 0.1657 0.3188
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Trichomonas vaginalis tubulin epsilon chain, putative 0.009 0.4855 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0018 0.0138 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Plasmodium vivax delta tubulin, putative 0.0018 0.0138 0.0284
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Plasmodium falciparum alpha tubulin 1 0.005 0.2214 0.4561
Trypanosoma cruzi alpha tubulin, putative 0.005 0.2214 0.4561
Leishmania major beta tubulin 0.009 0.4855 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0041 0.1657 0.1657
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.3501 0.7211
Echinococcus multilocularis cysteine protease 0.0018 0.0161 0.0161
Schistosoma mansoni tubulin subunit delta 0.0018 0.0138 0.0138
Schistosoma mansoni tubulin subunit beta 0.009 0.4855 0.4855
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0161 0.0048
Trypanosoma brucei alpha tubulin 0.005 0.2214 0.4561
Echinococcus granulosus tubulin alpha 1C chain 0.005 0.2214 0.2214
Trichomonas vaginalis tubulin beta chain, putative 0.0023 0.0491 0.0749
Echinococcus granulosus cathepsin l1 0.0018 0.0161 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Plasmodium vivax tubulin alpha chain, putative 0.005 0.2214 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Mycobacterium leprae cell division protein FtsZ 0.0018 0.0138 0.5
Trypanosoma brucei zeta tubulin, putative 0.0018 0.0138 0.0284
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Trypanosoma brucei beta tubulin 0.009 0.4855 1
Leishmania major cathepsin L-like protease 0.0018 0.0161 0.0331
Echinococcus multilocularis Tubulin beta 2C chain 0.009 0.4855 0.4855
Brugia malayi alpha-tubulin 0.005 0.2214 0.4561
Brugia malayi tubulin alpha chain - mouse 0.005 0.2214 0.4561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Leishmania major beta tubulin 0.009 0.4855 1
Leishmania major alpha tubulin 0.005 0.2214 0.4561
Trichomonas vaginalis tubulin, putative 0.009 0.4855 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3501 0.7211
Loa Loa (eye worm) cysteine protease 0.0018 0.0161 0.0331
Brugia malayi Cathepsin L-like precursor 0.0018 0.0161 0.0331
Trypanosoma brucei alpha tubulin 0.005 0.2214 0.4561
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0161 0.0161
Echinococcus granulosus tubulin alpha chain 0.005 0.2214 0.2214
Mycobacterium tuberculosis Cell division protein FtsZ 0.0018 0.0138 1
Echinococcus multilocularis tubulin alpha chain 0.005 0.2214 0.2214
Echinococcus granulosus beta tubulin 0.009 0.4855 0.4855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0161 0.0048
Leishmania major beta tubulin 0.009 0.4855 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 100 uM In vitro vasodilatory activity in isolated rat aorta ChEMBL. 8164261
IC50 (functional) < 0.1 uM In vitro antiplatelet activity against arachidonic acid induced malondialdehyde production ChEMBL. 8164261

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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