TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.464 | Formula: C20H30N2O2
H donors: 1 H acceptors: 1 LogP: 2.48 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCN1CCC(CC1)CNC(=O)C1(CC1)c1cccc(c1)C
InChi: 1S/C20H30N2O2/c1-16-4-3-5-18(14-16)20(8-9-20)19(23)21-15-17-6-10-22(11-7-17)12-13-24-2/h3-5,14,17H,6-13,15H2,1-2H3,(H,21,23)
InChiKey: OYZOQRJDPCSOHB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0019	0.0056	0.0062
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0019	0.0056	0.0062
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0019	0.0056	0.0062
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0019	0.0056	0.062
Trypanosoma brucei	DNA damage repair protein, putative	0.0007	0.0005	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0012	0.0117
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0029	0.0101	0.0247
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0077	0.0226
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0019	0.0056	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0391	0.0561
Plasmodium falciparum	glutathione reductase	0.0011	0.0023	0.1606
Echinococcus granulosus	cyclin dependent kinase 1	0.0013	0.0031	0.0068
Echinococcus multilocularis	ryanodine receptor 44f	0.0696	0.3066	0.7742
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0019	0.0056	0.0132
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0011	0.0023	0.0811
Plasmodium vivax	phospholipase C-like, putative	0.0025	0.0082	0.6828
Echinococcus granulosus	microtubule associated protein 2	0.0361	0.1578	0.3981
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0019	0.0056	0.0132
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0019	0.0056	0.0052
Echinococcus granulosus	ryanodine receptor 44f	0.0696	0.3066	0.7742
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Entamoeba histolytica	protein kinase, putative	0.0015	0.004	0.0424
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0019	0.0056	0.0132
Trichomonas vaginalis	1-phosphatidylinositol phosphodiesterase, putative	0.001	0.0019	0.0204
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0015	0.0038	0.0405
Echinococcus granulosus	cytohesin 1	0.0091	0.0377	0.0944
Schistosoma mansoni	voltage-gated ion channel	0.0019	0.0056	0.0062
Loa Loa (eye worm)	hypothetical protein	0.156	0.6907	1
Brugia malayi	phospholipase C homolog	0.0043	0.0165	0.0161
Echinococcus granulosus	NDR protein kinase	0.0007	0.0004	0.0000080509
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0011	0.0023	0.0605
Trypanosoma cruzi	cdc2-related kinase 1	0.0013	0.0031	0.0055
Echinococcus multilocularis	shaker cognate	0.0019	0.0056	0.0132
Echinococcus multilocularis	transient receptor potential cation channel	0.0019	0.0056	0.0132
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.007	0.0283	0.0404
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0015	0.004	0.0052
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0007	0.0004	0.0000046119
Schistosoma mansoni	DNA polymerase IV / kappa	0.0007	0.0005	0.0002
Onchocerca volvulus		0.001	0.0019	0.0182
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Trypanosoma brucei	unspecified product	0.0016	0.0045	0.0095
Echinococcus granulosus	serine:threonine protein kinase N2	0.0007	0.0004	0.0000080509
Schistosoma mansoni	hypothetical protein	0.019	0.0817	0.0967
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0013	0.0031	0.008
Schistosoma mansoni	transient receptor potential channel	0.0019	0.0056	0.0062
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0012	0.0117
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0007	0.0004	0.0000046119
Echinococcus granulosus	voltage gated potassium channel	0.0019	0.0056	0.0132
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0011	0.0023	0.0049
Trypanosoma cruzi	trypanothione reductase, putative	0.0011	0.0023	0.0039
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0077	0.0153
Plasmodium falciparum	glutathione reductase	0.0033	0.0118	1
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0025	0.0082	0.0079
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0033	0.0118	0.0288
Echinococcus multilocularis	sodium channel protein	0.0019	0.0056	0.0132
Echinococcus multilocularis	two pore calcium channel protein 1	0.0019	0.0056	0.0132
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0016	0.0045	0.0059
Toxoplasma gondii	transporter, cation channel family protein	0.0019	0.0056	0.2271
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Trypanosoma cruzi	CYC2-like cyclin 4, putative	0.0008	0.0007	0.0004
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.0045	0.0505
Entamoeba histolytica	protein kinase, putative	0.0016	0.0045	0.0484
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.001	0.0019	0.0022
Brugia malayi	hypothetical protein	0.001	0.0019	0.0015
Echinococcus granulosus	shaker cognate	0.0019	0.0056	0.0132
Echinococcus multilocularis	voltage dependent calcium channel	0.0019	0.0056	0.0132
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0019	0.0056	0.0076
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0008	0.0007	0.008
Brugia malayi	Doublecortin family protein	0.001	0.0019	0.0015
Schistosoma mansoni	loxhd1	0.001	0.0019	0.0018
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.001	0.0019	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0021	0.023
Schistosoma mansoni	phospholipase C beta	0.001	0.0019	0.0018
Echinococcus multilocularis	stromal cell derived factor 2	0.0196	0.0846	0.213
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0021	0.023
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.1057	0.4673	1
Echinococcus granulosus	sodium leak channel non selective protein	0.0019	0.0056	0.0132
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0019	0.0056	0.0132
Schistosoma mansoni	atypical protein kinase C	0.001	0.0018	0.0017
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0019	0.0056	0.0052
Echinococcus granulosus	voltage dependent calcium channel	0.0019	0.0056	0.0132
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0011	0.0023	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Brugia malayi	protein kinase C II.	0.0012	0.0027	0.0023
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0077	0.0153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0008	0.0073
Echinococcus granulosus	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Brugia malayi	phospholipase C homolog	0.0016	0.0046	0.0042
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0077	0.0106
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0016	0.0045	0.0103
Echinococcus granulosus	potassium large conductance calcium activated	0.0019	0.0056	0.0132
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0019	0.0056	0.0062
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0019	0.0056	0.0132
Plasmodium falciparum	phosphoinositide-specific phospholipase C	0.0025	0.0082	0.6828
Echinococcus multilocularis	short transient receptor potential channel 6	0.0019	0.0056	0.0132
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0008	0.0011	0.0081
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0039
Loa Loa (eye worm)	MIR domain-containing protein	0.0196	0.0846	0.122
Schistosoma mansoni	hypothetical protein	0.0019	0.0056	0.0062
Echinococcus multilocularis	cytohesin 1	0.0091	0.0377	0.0944
Schistosoma mansoni	hypothetical protein	0.001	0.0019	0.0018
Trypanosoma brucei	DNA polymerase kappa, putative	0.0007	0.0005	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0426
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0011	0.0113
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.1898	0.8412	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0011	0.0023	0.0811
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0039	0.0146	0.0301
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0015	0.0038	0.007
Brugia malayi	Protein kinase c protein 2	0.0026	0.0089	0.0085
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0077	0.0087
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0016	0.0045	0.0041
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0019	0.0056	0.0132
Trypanosoma brucei	unspecified product	0.0023	0.0077	0.0164
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0008	0.0072
Echinococcus multilocularis	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Echinococcus granulosus	transient receptor potential cation channel	0.0019	0.0056	0.0132
Echinococcus granulosus	hypothetical protein	0.0019	0.0056	0.0132
Echinococcus multilocularis	two pore calcium channel protein 2	0.0019	0.0056	0.0132
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0039
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0019	0.0056	0.0132
Leishmania major	phosphoinositide-specific phospholipase C, putative	0.0037	0.0136	0.0415
Schistosoma mansoni	serine/threonine-protein kinase	0.0008	0.0011	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Echinococcus multilocularis	cyclin dependent kinase 1	0.0013	0.0031	0.0068
Trypanosoma cruzi	trypanothione reductase, putative	0.0033	0.0118	0.0242
Echinococcus multilocularis	microtubule associated protein 2	0.0361	0.1578	0.3981
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.1057	0.4673	1
Trypanosoma brucei	trypanothione reductase	0.0033	0.0118	0.0253
Echinococcus multilocularis	transient receptor potential cation channel	0.0019	0.0056	0.0132
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.007	0.0283	0.0279
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0019	0.0056	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0153	0.0653	0.7704
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0051	0.0199	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0078	0.0107
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0019	0.0056	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0017	0.0173
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Loa Loa (eye worm)	voltage-gated potassium channel	0.0019	0.0056	0.0076
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0019	0.0056	0.0132
Trypanosoma cruzi	target of rapamycin kinase 3	0.0012	0.0025	0.0042
Echinococcus multilocularis	serine threonine protein kinase	0.0029	0.0104	0.0253
Toxoplasma gondii	cyclin2 related protein	0.0008	0.0007	0.008
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0007	0.0004	0.0000080509
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0019	0.0056	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0033	0.0118	0.0289
Schistosoma mansoni	vesicular amine transporter	0.0019	0.0056	0.0062
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0077	0.0184
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0077	0.2382
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0007	0.0004	0.0000080509
Loa Loa (eye worm)	doublecortin family protein	0.001	0.0019	0.0022
Echinococcus granulosus	transient receptor potential cation channel	0.0019	0.0056	0.0132
Echinococcus granulosus	voltage dependent calcium channel	0.0019	0.0056	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Schistosoma mansoni	lipoxygenase	0.001	0.0019	0.0018
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0077	0.0885
Echinococcus multilocularis	transient receptor potential cation channel	0.0019	0.0056	0.0132
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0019	0.0056	0.0132
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Echinococcus granulosus	thioredoxin glutathione reductase	0.0033	0.0118	0.0289
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0013	0.0031	0.1139
Echinococcus granulosus	short transient receptor potential channel 6	0.0019	0.0056	0.0132
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0077	0.0184
Echinococcus multilocularis	calcium activated potassium channel	0.0019	0.0058	0.0137
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0019	0.0056	0.0132
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0077	0.0073
Echinococcus granulosus	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Loa Loa (eye worm)	voltage-gated potassium channel	0.0019	0.0056	0.0076
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0019	0.0056	0.0062
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0153	0.0653	0.7704
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0118	0.0136
Brugia malayi	glutathione reductase	0.0033	0.0118	0.0114
Brugia malayi	MIR domain containing protein	0.0196	0.0846	0.0843
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0043	0.0165	0.0191
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0019	0.0056	0.016
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0019	0.0056	0.0052
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0039	0.0146	0.0312
Echinococcus multilocularis	ryanodine receptor 44f	0.0897	0.3958	1
Schistosoma mansoni	voltage-dependent calcium channel	0.0019	0.0056	0.0062
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0019	0.0056	0.0052
Trypanosoma brucei	glycosylphosphatidylinositol-specific phospholipase C	0.001	0.0019	0.0041
Trypanosoma brucei	unspecified product	0.0016	0.0045	0.0095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0021	0.023
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0019	0.0056	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.004	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0011	0.0023	0.028
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0077	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0337	0.0483
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0077	0.0184
Onchocerca volvulus		0.0072	0.0292	0.3416
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0031	0.0032
Echinococcus granulosus	transient receptor potential cation channel	0.0019	0.0056	0.0132
Echinococcus multilocularis	Polycystic kidney disease protein	0.001	0.0019	0.0038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0008	0.0072
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0077	0.1892
Leishmania major	hypothetical protein, conserved	0.0719	0.3168	1
Trichomonas vaginalis	mercuric reductase, putative	0.0011	0.0023	0.0254
Plasmodium falciparum	LCCL domain-containing protein	0.001	0.0019	0.1213
Echinococcus granulosus	Polycystic kidney disease protein	0.001	0.0019	0.0038
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0011	0.0023	0.005
Entamoeba histolytica	protein kinase, putative	0.0011	0.0023	0.0224
Trichomonas vaginalis	CMGC family protein kinase	0.0013	0.0031	0.0341
Onchocerca volvulus		0.0035	0.0127	0.1459
Loa Loa (eye worm)	hypothetical protein	0.1359	0.6015	0.8707
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0019	0.0056	0.0132
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0045	0.0049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0008	0.0072
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0013	0.0031	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.004	0.0445
Echinococcus granulosus	hyperpolarization activated cyclic	0.0019	0.0056	0.0132
Echinococcus multilocularis	lipoxygenase domain containing protein	0.001	0.0019	0.0038
Brugia malayi	cell division control protein 2 homolog	0.0013	0.0031	0.0027
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0019	0.0056	0.062
Plasmodium vivax	cyclin, putative	0.0008	0.0007	0.0159
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0007	0.0004	0.0000046119
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0019	0.0056	0.0052
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Echinococcus granulosus	cyclin dependent kinase 5	0.0013	0.0031	0.0068
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0059	0.0238	0.0591
Echinococcus multilocularis	transient receptor potential cation channel	0.0019	0.0056	0.0132
Entamoeba histolytica	MIR domain protein	0.0196	0.0846	1
Leishmania major	phosphatidylinositol-specific phospholipase-like protein	0.0025	0.0082	0.0244
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0008	0.001	0.0006
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0019	0.0056	0.0132
Onchocerca volvulus		0.0196	0.0846	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0045	0.0095
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0075	0.0305	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0011	0.0023	0.0057
Toxoplasma gondii	transporter, cation channel family protein	0.0019	0.0056	0.2271
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0019	0.0056	0.0132
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.003	0.0109	0.0152
Trypanosoma cruzi	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0082	0.0337	0.0711
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0077	0.0087
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0019	0.0056	0.0062
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0019	0.0056	0.2271
Echinococcus multilocularis	cyclin dependent kinase 5	0.0013	0.0031	0.0068
Schistosoma mansoni	serine/threonine kinase	0.0007	0.0004	0.0000037865
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0007	0.0004	0.0000080509
Giardia lamblia	Kinase, CMGC CDK	0.0013	0.0031	0.0393
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0057
Entamoeba histolytica	protein kinase, putative	0.0015	0.004	0.0424
Schistosoma mansoni	ryanodine receptor related	0.1254	0.5546	0.6591
Plasmodium falciparum	cyclin, putative	0.0008	0.0007	0.0159
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.1359	0.6015	0.7149
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Entamoeba histolytica	cell division protein kinase 2, putative	0.0013	0.0031	0.0319
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0011	0.0023	0.1606
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0077	0.0153
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0012	0.0025	0.0062
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0015	0.0038	0.0405
Plasmodium falciparum	thioredoxin reductase	0.0033	0.0118	1
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0019	0.0056	0.0132
Loa Loa (eye worm)	hypothetical protein	0.002	0.0064	0.0087
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.0045	0.0505
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0077	0.0087
Trypanosoma brucei	hypothetical protein, conserved	0.0007	0.0005	0.0011
Echinococcus granulosus	transient receptor potential cation channel	0.0019	0.0056	0.0132
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0011	0.0023	0.005
Trypanosoma cruzi	Protein kinase B	0.0008	0.0011	0.0012
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0013	0.0031	0.0068
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0019	0.0056	0.0109
Schistosoma mansoni	hypothetical protein	0.019	0.0817	0.0967
Trypanosoma brucei	cyclin 2	0.0008	0.0007	0.0015
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0091	0.0377	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0007	0.0004	0.0000080509
Trichomonas vaginalis	AGC family protein kinase	0.0007	0.0004	0.0023
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Leishmania major	hypothetical protein, conserved	0.001	0.0019	0.0044
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0011	0.0023	0.0049
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0015	0.0038	0.0081
Loa Loa (eye worm)	Plcb4 protein	0.0057	0.0228	0.0325
Schistosoma mansoni	stromal cell-derived factor 2 precursor-like protein	0.0196	0.0846	0.1002
Trypanosoma brucei	DNA damage repair protein, putative	0.0007	0.0005	0.0011
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0019	0.0056	0.0132
Echinococcus multilocularis	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0011	0.0023	0.0605
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0021	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Echinococcus multilocularis	protein kinase c iota type	0.001	0.0018	0.0035
Schistosoma mansoni	microtubule-associated protein tau	0.0361	0.1578	0.1872
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0039
Leishmania major	CYC2-like cyclin, putative	0.0008	0.0007	0.0006
Echinococcus granulosus	two pore calcium channel protein 2	0.0019	0.0056	0.0132
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0075	0.0305	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0013	0.0031	0.0068
Echinococcus multilocularis	lipoxygenase domain containing protein	0.001	0.0019	0.0038
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0077	0.0153
Schistosoma mansoni	lipoxygenase	0.0029	0.0101	0.0116
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0011	0.0023	0.0039
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0019	0.0056	0.0052
Brugia malayi	Hr1 repeat family protein	0.0007	0.0004	0.0000031851
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0077	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Schistosoma mansoni	two-pore calcium channel	0.0019	0.0056	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0337	0.0483
Trypanosoma cruzi	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0082	0.0337	0.0711
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0077	0.0226
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0004	0.0000031851
Loa Loa (eye worm)	voltage-gated calcium channel	0.0019	0.0056	0.0076
Echinococcus multilocularis	transient receptor potential gamma protein	0.0019	0.0056	0.0132
Brugia malayi	polk-prov protein	0.0007	0.0005	0.0001
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0007	0.0004	0.0000080509
Echinococcus granulosus	lipoxygenase domain containing protein	0.001	0.0019	0.0038
Onchocerca volvulus		0.001	0.0019	0.018
Plasmodium vivax	multidomain scavenger receptor, putative	0.001	0.0019	0.1213
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0019	0.0056	0.0132
Loa Loa (eye worm)	glutathione reductase	0.0033	0.0118	0.0166
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0015	0.0038	0.0041
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.1254	0.5546	0.5545
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0019	0.0056	0.0052
Schistosoma mansoni	calcium-activated potassium channel	0.0019	0.0056	0.0062
Onchocerca volvulus		0.001	0.0019	0.018
Trypanosoma brucei	DNA polymerase kappa, putative	0.0007	0.0005	0.0011
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0019	0.0056	0.0132
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0019	0.0056	0.064
Schistosoma mansoni	phospholipase C beta	0.0057	0.0228	0.0267
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0011	0.0023	0.5
Onchocerca volvulus		0.0019	0.0056	0.062
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0028	0.0314
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0019	0.0056	0.0062
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0012	0.0025	0.0053
Echinococcus granulosus	protein kinase c epsilon type	0.0012	0.0027	0.0059
Brugia malayi	Protein kinase domain containing protein	0.0015	0.004	0.0036
Echinococcus granulosus	hyperpolarization activated cyclic	0.0019	0.0056	0.0132
Plasmodium vivax	glutathione reductase, putative	0.0033	0.0118	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0025	0.0269
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0045	0.0095
Echinococcus granulosus	ryanodine receptor 44f	0.0897	0.3958	1
Trichomonas vaginalis	CMGC family protein kinase	0.0013	0.0031	0.0341
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0019	0.0056	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0238	0.0339
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0004	0.0000037865
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0021	0.0222
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0039
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0075	0.0305	1
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0019	0.0056	0.0132
Trichomonas vaginalis	AGC family protein kinase	0.0007	0.0004	0.0023
Giardia lamblia	Fructose-bisphosphate aldolase	0.0153	0.0653	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0019	0.0056	0.0132
Loa Loa (eye worm)	hypothetical protein	0.1537	0.6805	0.9851
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0019	0.0056	0.0132
Brugia malayi	voltage-dependent calcium channel	0.0019	0.0056	0.0052
Brugia malayi	Cytohesin 3	0.0091	0.0377	0.0374
Echinococcus multilocularis	transient receptor potential cation channel	0.0019	0.0056	0.0132
Treponema pallidum	fructose-bisphosphate aldolase	0.0153	0.0653	1
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.004	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0002
Loa Loa (eye worm)	thioredoxin reductase	0.0033	0.0118	0.0166
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0019	0.0056	0.0132
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0019	0.0056	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0025	0.0269
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0011	0.0023	0.0027
Echinococcus granulosus	RUN	0.001	0.0019	0.0038
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0011	0.0023	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0011	0.0113
Brugia malayi	Thioredoxin reductase	0.0033	0.0118	0.0114
Giardia lamblia	Kinase, CMGC CDK	0.0013	0.0031	0.0393
Echinococcus granulosus	protein kinase c iota type	0.001	0.0018	0.0035
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0077	0.1103
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0019	0.0056	0.0132
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0011	0.0023	0.0023
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Schistosoma mansoni	rab6-interacting	0.001	0.0019	0.0018
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0033	0.0118	0.3366
Echinococcus multilocularis	cyclin dependent kinase	0.0013	0.0031	0.0068
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0019	0.0056	0.0052
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0019	0.0056	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Echinococcus multilocularis	conserved hypothetical protein	0.0019	0.0056	0.0132
Echinococcus granulosus	protein kinase C gamma type	0.0029	0.0104	0.0253
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0004	0.0000037865
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0021	0.023
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0019	0.0056	0.0076
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0011	0.0023	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Brugia malayi	p70 ribosomal S6 kinase beta	0.0011	0.0023	0.0019
Echinococcus multilocularis	voltage gated potassium channel	0.0019	0.0056	0.0132
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0007	0.0004	0.0000046119
Toxoplasma gondii	transporter, cation channel family protein	0.0019	0.0056	0.2271
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0029	0.0101	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0021	0.023
Echinococcus multilocularis	voltage gated potassium channel	0.0019	0.0056	0.0132
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0077	0.0865
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0007	0.0004	0.0000080509
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0015	0.0038	0.0103
Echinococcus granulosus	short transient receptor potential channel 6	0.0019	0.0056	0.0132
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0007	0.0004	0.0000046119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0015	0.0157
Loa Loa (eye worm)	cytohesin 3	0.0091	0.0377	0.0541
Loa Loa (eye worm)	calcium channel	0.0019	0.0056	0.0076
Echinococcus granulosus	RNA directed DNA polymerase	0.002	0.0064	0.0152
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0008	0.0011	0.0012
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0019	0.0056	0.0062
Echinococcus granulosus	dna polymerase eta	0.0023	0.0077	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.004	0.0445
Schistosoma mansoni	polycystin 1-related	0.001	0.0019	0.0018
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0077	0.0153
Loa Loa (eye worm)	ryanodine receptor	0.0339	0.1478	0.2135
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0011	0.0023	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0027	0.0028
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0019	0.0056	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.0045	0.0505
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0038	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Loa Loa (eye worm)	ryanodine receptor	0.0019	0.0056	0.0076
Schistosoma mansoni	serine/threonine-protein kinase	0.0008	0.0011	0.0008
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0019	0.0056	0.0062
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0016	0.0045	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.004	0.0445
Plasmodium vivax	protein kinase Crk2	0.0013	0.0031	0.2253
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0011	0.0023	0.5
Schistosoma mansoni	transient receptor potential channel	0.0019	0.0056	0.0062
Leishmania major	trypanothione reductase	0.0033	0.0118	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Echinococcus multilocularis	RUN	0.001	0.0019	0.0038
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0007	0.0004	0.0000080509
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0019	0.0056	0.0062
Echinococcus granulosus	TRP transient receptor potential channel	0.0019	0.0056	0.0132
Brugia malayi	hypothetical protein	0.0019	0.0056	0.0052
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0019	0.0056	0.0132
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0118	0.0136
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0011	0.0023	0.1606
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0019	0.0056	0.0052
Echinococcus granulosus	stromal cell derived factor 2	0.0196	0.0846	0.213
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0019	0.0056	0.0132
Trypanosoma brucei	cdc2-related kinase 1	0.0013	0.0031	0.0066
Echinococcus granulosus	sodium channel protein	0.0019	0.0056	0.0132
Brugia malayi	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4	0.0057	0.0228	0.0224
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0077	0.0184
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0011	0.0023	0.005
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0004	0.0000037865
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0015	0.0038	0.007
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0019	0.0056	0.0132
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0039
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0011	0.0023	0.1606
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0011	0.0023	0.0057
Brugia malayi	hypothetical protein	0.001	0.0019	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0022
Echinococcus granulosus	voltage gated potassium channel	0.0019	0.0056	0.0132
Trypanosoma cruzi	cdc2-related kinase 1	0.0013	0.0031	0.0055
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.002	0.0064	0.0152
Echinococcus granulosus	transient receptor potential cation channel	0.0019	0.0056	0.0132
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0019	0.0056	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Echinococcus granulosus	transient receptor potential gamma protein	0.0019	0.0056	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0025	0.0269
Trichomonas vaginalis	CMGC family protein kinase	0.0013	0.0031	0.0341
Toxoplasma gondii	hypothetical protein	0.0019	0.0056	0.2271
Echinococcus multilocularis	voltage dependent calcium channel	0.0019	0.0056	0.0132
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0008	0.0007	0.0004
Trypanosoma cruzi	cdc2-related kinase 3	0.0013	0.0031	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0426
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0011	0.0023	0.002
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0019	0.0056	0.0132
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0015	0.0038	0.0081
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0007	0.006
Echinococcus multilocularis	transfer RNA-Gly	0.0019	0.0056	0.0132
Trichomonas vaginalis	glutathione reductase, putative	0.0011	0.0023	0.0254
Brugia malayi	ion channel NompC	0.0019	0.0056	0.0052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0008	0.0073
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0025	0.0269
Schistosoma mansoni	transient receptor potential channel	0.0019	0.0056	0.0062
Trypanosoma brucei	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0086	0.0354	0.0758
Giardia lamblia	GTOR	0.0015	0.0038	0.0505
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0015	0.0038	0.0086
Toxoplasma gondii	thioredoxin reductase	0.0033	0.0118	0.5054
Echinococcus multilocularis	sodium leak channel non selective protein	0.0019	0.0056	0.0132
Toxoplasma gondii	AGC kinase	0.0011	0.0023	0.0781
Leishmania major	hypothetical protein, unknown function	0.0019	0.0056	0.016
Echinococcus granulosus	transient receptor potential cation channel	0.0019	0.0056	0.0132
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0019	0.0056	0.0132
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0077	0.2382
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Trypanosoma brucei	CYC2-like cyclin, putative	0.0008	0.0007	0.0015
Brugia malayi	Variant SH3 domain containing protein	0.003	0.0109	0.0105
Echinococcus granulosus	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0023	0.0075	0.0103
Leishmania major	phospholipase c-like protein	0.0039	0.0146	0.0445
Brugia malayi	cation channel family protein	0.0019	0.0056	0.0052
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0011	0.0023	0.1606
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0337	0.0483
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.004	0.0445
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0077	0.0184
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0007	0.0004	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0013	0.0031	0.0039
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0019	0.0056	0.012
Trichomonas vaginalis	1-phosphatidylinositol phosphodiesterase, putative	0.001	0.0019	0.0204
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0007	0.0004	0.0000080509
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0019	0.0056	0.064
Echinococcus multilocularis	geminin	0.019	0.0817	0.2056
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0019	0.0056	0.0076
Plasmodium vivax	thioredoxin reductase, putative	0.0033	0.0118	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0077	0.0106
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0015	0.004	0.0085
Schistosoma mansoni	transient receptor potential channel 4	0.0019	0.0056	0.0062
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0013	0.0031	0.0039
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0031	0.0027
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0007	0.0004	0.0000080509
Echinococcus granulosus	Protein kinase C brain isozyme	0.0033	0.0118	0.0288
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0426
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0016	0.0045	0.0059
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0019	0.0056	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.004	0.0445
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0019	0.0056	0.2271
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0008	0.0011	0.0081
Echinococcus multilocularis	short transient receptor potential channel 6	0.0019	0.0056	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Entamoeba histolytica	cell division protein kinase 2, putative	0.0013	0.0031	0.0319
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0019	0.0056	0.0076
Echinococcus granulosus	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Echinococcus granulosus	serine/threonine protein kinase	0.0008	0.0011	0.0017
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0008	0.001	0.0006
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0015	0.0038	0.0086
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0019	0.0056	0.0132
Leishmania major	DNA polymerase eta, putative	0.0023	0.0077	0.0226
Schistosoma mansoni	60S ribosomal protein L21	0.0019	0.0056	0.0062
Echinococcus granulosus	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Trypanosoma cruzi	CYC2-like cyclin 6, putative	0.0008	0.0007	0.0004
Echinococcus granulosus	geminin	0.019	0.0817	0.2056
Trypanosoma cruzi	cdc2-related kinase 3	0.0013	0.0031	0.0055
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0011	0.0021	0.0719
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0019	0.0056	0.0132
Echinococcus multilocularis	RNA directed DNA polymerase	0.002	0.0064	0.0152
Toxoplasma gondii	hypothetical protein	0.0019	0.0056	0.2271
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0153	0.0653	0.7709
Trichomonas vaginalis	AGC family protein kinase	0.0007	0.0004	0.0023
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0022
Echinococcus multilocularis	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0019	0.0056	0.0062
Echinococcus multilocularis	potassium large conductance calcium activated	0.0019	0.0056	0.0132
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0019	0.0056	0.0062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0045	0.0095
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0056	0.0062
Plasmodium falciparum	thioredoxin reductase	0.0011	0.0023	0.1606
Echinococcus multilocularis	rac serine:threonine kinase	0.0008	0.0011	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0082	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0004	0.0000031851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0025	0.0269
Echinococcus granulosus	calcium activated potassium channel	0.0019	0.0058	0.0137
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Trypanosoma brucei	hypothetical protein, conserved	0.0007	0.0005	0.0011
Echinococcus multilocularis	potassium voltage gated channel protein	0.0019	0.0056	0.0132
Schistosoma mansoni	ryanodine receptor 1 skeletal muscle	0.0339	0.1478	0.1753
Trypanosoma brucei	chrX additional, unordered contigs	0.0007	0.0005	0.0011
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0013	0.0031	0.008
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0019	0.0056	0.0132
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0077	0.0073
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0012	0.0117
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0008	0.0073
Echinococcus multilocularis	transient receptor potential cation channel	0.0019	0.0056	0.0132
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0045	0.0041
Loa Loa (eye worm)	ion channel NompC	0.0019	0.0056	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0021	0.023
Plasmodium falciparum	protein kinase 5	0.0013	0.0031	0.2253
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0015	0.0038	0.0103
Schistosoma mansoni	rab6-interacting	0.001	0.0019	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0029	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0004	0.0000037865
Loa Loa (eye worm)	hypothetical protein	0.0897	0.3958	0.5728
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0056	0.0076
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0019	0.0056	0.0062
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0077	0.0164
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0004	0.0000046119
Trypanosoma brucei	cdc2-related kinase 3	0.0013	0.0031	0.0066
Echinococcus granulosus	two pore calcium channel protein 1	0.0019	0.0056	0.0132
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0019	0.0056	0.0052
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0058	0.0229	1
Brugia malayi	olfactory channel protein osm-9	0.0019	0.0056	0.0052
Brugia malayi	Transient-receptor-potential like protein	0.0019	0.0056	0.0052
Echinococcus multilocularis	protein kinase c epsilon type	0.0012	0.0027	0.0059
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0038	0.0049
Onchocerca volvulus		0.0102	0.0429	0.5042
Schistosoma mansoni	voltage-gated cation channel	0.0019	0.0056	0.0062
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0012	0.0027	0.0034
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0077	0.1892
Echinococcus granulosus	lipoxygenase domain containing protein	0.001	0.0019	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0077	0.0164
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0019	0.0056	0.0052
Leishmania major	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0082	0.0337	0.105
Echinococcus granulosus	cyclin dependent kinase	0.0013	0.0031	0.0068
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0059	0.0238	0.0591
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0077	0.0885
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0031	0.0032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0008	0.0073
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0019	0.0056	0.0052
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0019	0.0056	0.0052
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0196	0.0846	1
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0019	0.0056	0.0052
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0077	0.0164
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0011	0.0023	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0127	0.0178

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3496278

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2069263