Detailed information for compound 2070445

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.404 | Formula: C19H21N5
  • H donors: 1 H acceptors: 3 LogP: 1.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1ncc2c1CCCC2NCc1cnc(nc1)c1ccccc1
  • InChi: 1S/C19H21N5/c1-24-18-9-5-8-17(16(18)13-23-24)20-10-14-11-21-19(22-12-14)15-6-3-2-4-7-15/h2-4,6-7,11-13,17,20H,5,8-10H2,1H3
  • InChiKey: RZQSWFGLYITRRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.027 0.1547 0.44
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.027 0.1547 0.2357
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.003 0.2366
Loa Loa (eye worm) TAR-binding protein 0.0045 0.0118 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0573 0.3469 0.8131
Onchocerca volvulus Bile acid receptor homolog 0.0573 0.3469 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.235 0.5482
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0126 0.0227
Echinococcus multilocularis snurportin 1 0.0352 0.2069 0.2045
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0122 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0122 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0 0.5
Mycobacterium ulcerans putative regulatory protein 0.0032 0.0036 0.0416
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0397 0.235 0.5482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.1651 0.2519
Entamoeba histolytica hypothetical protein 0.0109 0.0524 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.0449 0.8585
Schistosoma mansoni RAR-like nuclear receptor 0.0573 0.3469 0.5344
Brugia malayi Nuclear hormone receptor E75 0.027 0.1547 0.3601
Echinococcus multilocularis ecdysone induced protein 78C 0.0573 0.3469 0.345
Brugia malayi Importin beta-1 subunit 0.0033 0.004 0.005
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.136 0.2066
Echinococcus granulosus geminin 0.1044 0.6466 1
Brugia malayi laminin alpha chain 0.0161 0.0854 0.1968
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0573 0.3469 0.5344
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.136 0.1334
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0303 0.1752 0.2677
Echinococcus granulosus pikachurin 0.0161 0.0854 0.128
Brugia malayi RNA recognition motif domain containing protein 0.0045 0.0118 0.0234
Echinococcus multilocularis neurogenic locus notch protein 0.0161 0.0854 0.0826
Loa Loa (eye worm) DR-78 0.027 0.1547 0.3584
Loa Loa (eye worm) hypothetical protein 0.0161 0.0854 0.1946
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0125 0.0627 0.0599
Brugia malayi small heat shock protein 0.0698 0.4262 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0573 0.3469 0.8131
Entamoeba histolytica hypothetical protein 0.0109 0.0524 1
Echinococcus granulosus neurogenic locus notch protein 0.0161 0.0854 0.128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.027 0.1547 0.2357
Loa Loa (eye worm) abnormal epIthelia family member 0.0161 0.0854 0.1946
Brugia malayi glutathione reductase 0.0043 0.0101 0.0195
Plasmodium vivax glutathione reductase, putative 0.0043 0.0101 0.746
Schistosoma mansoni coup transcription factor 0.0573 0.3469 0.5344
Brugia malayi Nuclear hormone receptor-like 1 0.0573 0.3469 0.8131
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0573 0.3469 0.8131
Brugia malayi tailless protein 0.027 0.1547 0.3601
Loa Loa (eye worm) hypothetical protein 0.0147 0.0764 0.1734
Echinococcus multilocularis thyroid hormone receptor alpha 0.0573 0.3469 0.345
Brugia malayi MH2 domain containing protein 0.0108 0.0515 0.1169
Brugia malayi nuclear receptor RXR 0.027 0.1547 0.3601
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Brugia malayi nuclear hormone receptor 0.027 0.1547 0.3601
Onchocerca volvulus 0.027 0.1547 0.44
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0142 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0118 0.0137
Trypanosoma brucei trypanothione reductase 0.0043 0.0101 0.7428
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0303 0.1752 0.1728
Loa Loa (eye worm) hypothetical protein 0.0271 0.1553 0.3598
Loa Loa (eye worm) hypothetical protein 0.0303 0.1752 0.407
Trypanosoma brucei PAB1-binding protein , putative 0.0046 0.0122 0.9608
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.003 0.168
Brugia malayi RNA, U transporter 1 0.0094 0.0426 0.0961
Onchocerca volvulus 0.0119 0.0584 0.1597
Brugia malayi photoreceptor-specific nuclear receptor 0.0573 0.3469 0.8131
Schistosoma mansoni cell polarity protein 0.0161 0.0854 0.128
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0116 0.586
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Brugia malayi steroid hormone receptor 0.0573 0.3469 0.8131
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.027 0.1547 0.1521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.1651 0.2519
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0101 0.1464
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0318 0.0682
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0573 0.3469 0.5344
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.004 0.1026
Brugia malayi Ets-domain containing protein 0.0077 0.0318 0.0706
Echinococcus granulosus Nuclear hormone receptor HR96 0.027 0.1547 0.2357
Schistosoma mansoni hypothetical protein 0.0125 0.0627 0.0928
Echinococcus multilocularis geminin 0.1044 0.6466 0.6455
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0177 0.0229
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0045 0.0116 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.0247 0.0514
Echinococcus granulosus nuclear receptor nhr 48 0.027 0.1547 0.2357
Brugia malayi RNA binding protein 0.0045 0.0118 0.0234
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Loa Loa (eye worm) glutathione reductase 0.0043 0.0101 0.0169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0287 0.1651 0.3831
Schistosoma mansoni slit 0.0161 0.0854 0.128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0573 0.3469 0.5344
Schistosoma mansoni ets-related 0.0233 0.1313 0.1993
Schistosoma mansoni nuclear hormone receptor 0.027 0.1547 0.2357
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0573 0.3469 0.345
Brugia malayi EGF-like domain containing protein 0.0161 0.0854 0.1968
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0177 0.0148
Loa Loa (eye worm) hypothetical protein 0.0161 0.0854 0.1946
Entamoeba histolytica hypothetical protein 0.0109 0.0524 1
Leishmania major cytochrome p450-like protein 0.0047 0.0126 0.7102
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0101 0.0072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0573 0.3469 0.345
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0045 0.0116 0.0134
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0573 0.3469 0.8127
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Loa Loa (eye worm) hypothetical protein 0.0241 0.136 0.3142
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0118 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0177 0.0229
Brugia malayi latrophilin 2 splice variant baaae 0.0271 0.1553 0.3615
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0125 0.0627 0.0599
Schistosoma mansoni survival motor neuron protein 0.0049 0.0142 0.0174
Brugia malayi cytochrome P450 0.0031 0.003 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0573 0.3469 0.8131
Loa Loa (eye worm) nuclear receptor nhr-7B 0.027 0.1547 0.3584
Onchocerca volvulus 0.0573 0.3469 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0524 0.0496
Schistosoma mansoni nuclear hormone receptor 0.0573 0.3469 0.5344
Brugia malayi Cytochrome P450 family protein 0.0047 0.0126 0.0253
Schistosoma mansoni nuclear receptor 0.027 0.1547 0.2357
Leishmania major cytochrome p450-like protein 0.0031 0.003 0.168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0573 0.3469 0.5344
Schistosoma mansoni thyroid hormone receptor 0.0573 0.3469 0.5344
Echinococcus granulosus slit 2 protein 0.0161 0.0854 0.128
Brugia malayi Latrophilin receptor protein 2 0.0125 0.0627 0.1434
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Schistosoma mansoni nuclear receptor nhr-48 0.027 0.1547 0.2357
Echinococcus granulosus single minded 2 0.0032 0.0036 0.001
Brugia malayi Cytochrome P450 family protein 0.0064 0.0234 0.0508
Schistosoma mansoni hypothetical protein 0.0352 0.2069 0.3168
Echinococcus multilocularis Nuclear hormone receptor HR96 0.027 0.1547 0.1521
Brugia malayi TAR-binding protein 0.0045 0.0118 0.0234
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Schistosoma mansoni hypothetical protein 0.0125 0.0627 0.0928
Brugia malayi bHLH-PAS transcription factor 0.0032 0.0036 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0573 0.3469 0.8131
Brugia malayi nuclear hormone receptor 0.0573 0.3469 0.8131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0573 0.3469 0.8127
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.0303 0.1752 0.407
Toxoplasma gondii LsmAD domain-containing protein 0.0046 0.0122 0.6261
Schistosoma mansoni hypothetical protein 0.0125 0.0627 0.0928
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.027 0.1547 0.3601
Brugia malayi nuclear hormone receptor family member odr-7 0.027 0.1547 0.3601
Brugia malayi laminin-like protein K08C7.3 precursor 0.0161 0.0854 0.1968
Brugia malayi hypothetical protein 0.0303 0.1752 0.4086
Echinococcus granulosus FTZ F1 alpha 0.0573 0.3469 0.5344
Brugia malayi Ets-domain containing protein 0.0077 0.0318 0.0706
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.027 0.1547 0.1521
Brugia malayi hypothetical protein 0.0241 0.136 0.3161
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0042 0.0097 0.0159
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0573 0.3469 0.345
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0177 1
Brugia malayi conserved hypotetical protein 0.027 0.1547 0.3601
Plasmodium vivax ataxin-2 like protein, putative 0.0046 0.0122 1
Echinococcus multilocularis FTZ F1 alpha 0.0573 0.3469 0.345
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Loa Loa (eye worm) fli-1 protein 0.0233 0.1313 0.3031
Loa Loa (eye worm) latrophilin receptor protein 2 0.0125 0.0627 0.1412
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0177 1
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.004 0.0669
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.2069 0.4817
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.1651 0.2519
Brugia malayi orphan nuclear receptor NR2E1 0.027 0.1547 0.3601
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0573 0.3469 0.5344
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0524 0.0769
Loa Loa (eye worm) RNA binding protein 0.0045 0.0118 0.0208
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0303 0.1752 0.407
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0234 0.0483
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Echinococcus granulosus thyroid hormone receptor alpha 0.027 0.1547 0.2357
Mycobacterium tuberculosis Probable reductase 0.0097 0.0449 0.8585
Leishmania major trypanothione reductase 0.0043 0.0101 0.5708
Loa Loa (eye worm) hypothetical protein 0.0303 0.1752 0.407
Brugia malayi hypothetical protein 0.0119 0.0584 0.1333
Schistosoma mansoni hypothetical protein 0.1044 0.6466 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0573 0.3469 0.345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0573 0.3469 0.8127
Brugia malayi Nuclear hormone receptor-like 1 0.0303 0.1752 0.4086
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0126 0.0227
Schistosoma mansoni hypothetical protein 0.0049 0.0142 0.0174
Echinococcus granulosus snurportin 1 0.0352 0.2069 0.3168
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0177 0.3023
Plasmodium falciparum glutathione reductase 0.0043 0.0101 0.746
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0118 0.0137
Brugia malayi nuclear receptor NHR-88 0.027 0.1547 0.3601
Brugia malayi Steroid receptor seven-up type 2 0.0573 0.3469 0.8131
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.004 0.1026
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.027 0.1547 0.44
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0126 0.6517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0573 0.3469 0.8127
Schistosoma mansoni hypothetical protein 0.0109 0.0524 0.0769
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0116 0.0134
Trichomonas vaginalis importin beta-1, putative 0.0027 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0125 0.0627 0.1412
Loa Loa (eye worm) hypothetical protein 0.0698 0.4262 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0573 0.3469 0.8131
Brugia malayi nuclear hormone receptor family member nhr-6 0.027 0.1547 0.3601
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0573 0.3469 0.5344
Loa Loa (eye worm) hypoxia-induced factor 1 0.0136 0.0691 0.1563
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0573 0.3469 0.5344
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0573 0.3469 0.8131
Brugia malayi hypothetical protein 0.027 0.1547 0.3601
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0318 0.0448
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0118 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.1651 0.1626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0573 0.3469 0.8127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0573 0.3469 0.5344
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0122 0.97
Schistosoma mansoni nuclear hormone receptor 0.027 0.1547 0.2357
Leishmania major hypothetical protein, conserved 0.0046 0.0122 0.6889
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0573 0.3469 0.8131
Entamoeba histolytica hypothetical protein 0.0109 0.0524 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0573 0.3469 0.8127
Brugia malayi Nuclear hormone receptor-like 1 0.0303 0.1752 0.4086
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0177 0.0229
Schistosoma mansoni single-minded 0.0044 0.0108 0.0122
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.027 0.1547 0.2357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.1651 0.2519
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.0449 0.8585
Echinococcus granulosus importin subunit beta 1 0.0033 0.004 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0573 0.3469 0.5344
Brugia malayi hypoxia-induced factor 1 0.0136 0.0691 0.1585
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0573 0.3469 0.8131
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0161 0.0854 0.128
Schistosoma mansoni laminin gamma-3 chain 0.0161 0.0854 0.128
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0126 1
Onchocerca volvulus 0.0049 0.0142 0.0309
Brugia malayi hypothetical protein 0.027 0.1547 0.3601
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0177 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.003 0.2366
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0126 1
Brugia malayi Thioredoxin reductase 0.0043 0.0101 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.027 0.1547 0.1521
Echinococcus multilocularis slit 2 protein 0.0161 0.0854 0.0826
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0573 0.3469 0.5344
Loa Loa (eye worm) MH2 domain-containing protein 0.0108 0.0515 0.1146
Plasmodium falciparum thioredoxin reductase 0.0043 0.0101 0.746
Schistosoma mansoni thyroid hormone receptor 0.0573 0.3469 0.5344
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0518 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0044 0.0108 0.0122
Brugia malayi nuclear receptor NHR-67 0.027 0.1547 0.3601
Schistosoma mansoni hypothetical protein 0.0271 0.1553 0.2366
Echinococcus multilocularis transfer RNA-Lys 0.0032 0.0036 0.0006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.027 0.1547 0.2357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0573 0.3469 0.8127
Loa Loa (eye worm) transcription factor SMAD2 0.0108 0.0515 0.1146
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.003 0.2366
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0045 0.0118 0.0208
Echinococcus multilocularis tar DNA binding protein 0.0045 0.0118 0.0088
Brugia malayi hypothetical protein 0.0303 0.1752 0.4086
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.0449 0.8585
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0573 0.3469 0.5344
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0101 0.0111
Loa Loa (eye worm) hypothetical protein 0.0303 0.1752 0.407
Leishmania major cytochrome p450-like protein 0.0031 0.003 0.168
Onchocerca volvulus Protein ultraspiracle homolog 0.0573 0.3469 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0125 0.0627 0.0928
Onchocerca volvulus 0.027 0.1547 0.44
Schistosoma mansoni gabp alpha 0.0077 0.0318 0.0448
Loa Loa (eye worm) nuclear hormone receptor 0.027 0.1547 0.3584
Brugia malayi ecdysone receptor 0.027 0.1547 0.3601
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Brugia malayi hypothetical protein 0.0147 0.0764 0.1756
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.0449 0.8585
Toxoplasma gondii thioredoxin reductase 0.0043 0.0101 0.4841
Brugia malayi PAS domain containing protein 0.0044 0.0108 0.0211
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0125 0.0627 0.0928
Brugia malayi Cytochrome P450 family protein 0.0047 0.0126 0.0253
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0177 1
Brugia malayi Nuclear hormone receptor E75 0.027 0.1547 0.3601
Schistosoma mansoni importin beta-1 0.0033 0.004 0.0015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0518 1
Schistosoma mansoni retinoic acid receptor RXR 0.0573 0.3469 0.5344
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.0449 0.8585
Brugia malayi Cytochrome P450 family protein 0.0031 0.003 0.0026
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0116 0.586
Echinococcus granulosus tar DNA binding protein 0.0045 0.0118 0.0137
Brugia malayi ecdysteroid receptor 0.0573 0.3469 0.8131
Loa Loa (eye worm) hypothetical protein 0.0033 0.004 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0573 0.3469 0.8131
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0573 0.3469 0.5344
Echinococcus granulosus GPCR family 2 0.0125 0.0627 0.0928
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0287 0.1651 0.3847
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0573 0.3469 0.345
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0045 0.0116 0.6556
Echinococcus multilocularis GPCR, family 2 0.0125 0.0627 0.0599
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0303 0.1752 0.2677
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Schistosoma mansoni hypothetical protein 0.1044 0.6466 1
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0524 0.0769
Brugia malayi Calcitonin receptor-like protein seb-1 0.0397 0.235 0.5494
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0118 0.0137
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0573 0.3469 0.5344
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.0449 0.8585
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0161 0.0854 0.1968
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0125 0.0627 0.1434
Echinococcus granulosus Nuclear hormone receptor HR96 0.027 0.1547 0.2357
Loa Loa (eye worm) hypothetical protein 0.0573 0.3469 0.8127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0573 0.3469 0.8131
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0303 0.1752 0.2677
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0122 0.97
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0177 1
Schistosoma mansoni zinc finger protein 0.027 0.1547 0.2357
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0101 0.8036
Brugia malayi hypothetical protein 0.0109 0.0524 0.1192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.1651 0.1626
Loa Loa (eye worm) nuclear receptor NHR-67 0.027 0.1547 0.3584
Loa Loa (eye worm) hypothetical protein 0.0119 0.0584 0.131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.1651 0.2519
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0573 0.3469 1
Brugia malayi Fli-1 protein 0.0233 0.1313 0.305
Loa Loa (eye worm) steroid hormone receptor 0.0573 0.3469 0.8127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0397 0.235 0.5494
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0045 0.0116 0.023
Loa Loa (eye worm) hypothetical protein 0.027 0.1547 0.3584
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0573 0.3469 0.8131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0573 0.3469 0.5344
Brugia malayi hypothetical protein 0.0046 0.0122 0.0244
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0126 0.0227
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0518 1
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0318 0.0289
Echinococcus granulosus ecdysone induced protein 78C 0.0573 0.3469 0.5344
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0518 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0573 0.3469 0.8131
Brugia malayi nuclear receptor RXR 0.0303 0.1752 0.4086
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0573 0.3469 0.345
Echinococcus multilocularis Nuclear hormone receptor HR96 0.027 0.1547 0.1521
Loa Loa (eye worm) hypothetical protein 0.0161 0.0854 0.1946
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0218
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0116 0.0087
Echinococcus multilocularis pikachurin 0.0161 0.0854 0.0826
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0101 0.0169
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0101 0.746
Schistosoma mansoni hypothetical protein 0.0125 0.0627 0.0928
Schistosoma mansoni nuclear receptor 0.027 0.1547 0.2357
Echinococcus multilocularis nuclear receptor nhr 48 0.027 0.1547 0.1521
Echinococcus multilocularis importin subunit beta 1 0.0033 0.004 0.001
Loa Loa (eye worm) hypothetical protein 0.0303 0.1752 0.407
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0573 0.3469 0.8131

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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