TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.404 | Formula: C19H21N5
H donors: 1 H acceptors: 3 LogP: 1.86 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cn1ncc2c1CCCC2NCc1cnc(nc1)c1ccccc1
InChi: 1S/C19H21N5/c1-24-18-9-5-8-17(16(18)13-23-24)20-10-14-11-21-19(22-12-14)15-6-3-2-4-7-15/h2-4,6-7,11-13,17,20H,5,8-10H2,1H3
InChiKey: RZQSWFGLYITRRT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0241	0.136	0.3161
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0573	0.3469	0.5344
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0573	0.3469	0.5344
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0136	0.0691	0.1563
Trichomonas vaginalis	importin beta-1, putative	0.0027	0	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0573	0.3469	0.5344
Loa Loa (eye worm)	fli-1 protein	0.0233	0.1313	0.3031
Echinococcus granulosus	ecdysone induced protein 78C	0.0573	0.3469	0.5344
Plasmodium vivax	thioredoxin reductase, putative	0.0043	0.0101	0.746
Echinococcus multilocularis	slit 2 protein	0.0161	0.0854	0.0826
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0101	0.0072
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.027	0.1547	0.2357
Brugia malayi	hypothetical protein	0.0303	0.1752	0.4086
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0573	0.3469	0.5344
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Schistosoma mansoni	ets-related	0.0233	0.1313	0.1993
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0	0.5
Brugia malayi	hypoxia-induced factor 1	0.0136	0.0691	0.1585
Brugia malayi	Cytochrome P450 family protein	0.0047	0.0126	0.0253
Schistosoma mansoni	aldehyde dehydrogenase	0.0055	0.0177	0.0229
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0109	0.0524	0.0496
Brugia malayi	hypothetical protein	0.0147	0.0764	0.1756
Schistosoma mansoni	hypothetical protein	0.0125	0.0627	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1752	0.407
Plasmodium falciparum	ataxin-2 like protein, putative	0.0046	0.0122	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0241	0.136	0.1334
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0287	0.1651	0.1626
Schistosoma mansoni	thyroid hormone receptor	0.0573	0.3469	0.5344
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0854	0.1946
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0573	0.3469	0.345
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1752	0.407
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0573	0.3469	0.5344
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0573	0.3469	0.5344
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0627	0.1412
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0573	0.3469	0.8127
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0287	0.1651	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1752	0.407
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0125	0.0627	0.0599
Echinococcus granulosus	single minded 2	0.0032	0.0036	0.001
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0573	0.3469	0.5344
Trypanosoma cruzi	PAB1-binding protein , putative	0.0046	0.0122	0.97
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0287	0.1651	0.1626
Echinococcus granulosus	GPCR family 2	0.0125	0.0627	0.0928
Echinococcus granulosus	geminin	0.1044	0.6466	1
Schistosoma mansoni	nuclear receptor	0.027	0.1547	0.2357
Brugia malayi	tailless protein	0.027	0.1547	0.3601
Echinococcus multilocularis	nuclear receptor nhr 48	0.027	0.1547	0.1521
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0161	0.0854	0.1968
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0573	0.3469	0.5344
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.027	0.1547	0.44
Loa Loa (eye worm)	hypothetical protein	0.0698	0.4262	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0125	0.0627	0.1434
Brugia malayi	Nuclear hormone receptor E75	0.027	0.1547	0.3601
Onchocerca volvulus	Protein ultraspiracle homolog	0.0573	0.3469	1
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0573	0.3469	0.8127
Schistosoma mansoni	importin beta-1	0.0033	0.004	0.0015
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Brugia malayi	hypothetical protein	0.027	0.1547	0.3601
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0573	0.3469	1
Brugia malayi	nuclear receptor RXR	0.0303	0.1752	0.4086
Brugia malayi	RNA recognition motif domain containing protein	0.0045	0.0118	0.0234
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Loa Loa (eye worm)	thioredoxin reductase	0.0043	0.0101	0.0169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0287	0.1651	0.2519
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Brugia malayi	Ets-domain containing protein	0.0077	0.0318	0.0706
Plasmodium falciparum	thioredoxin reductase	0.0043	0.0101	0.746
Schistosoma mansoni	zinc finger protein	0.027	0.1547	0.2357
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0055	0.0177	0.0148
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0118	0.0137
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0101	0.0111
Leishmania major	trypanothione reductase	0.0043	0.0101	0.5708
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0097	0.0449	0.8585
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0303	0.1752	0.2677
Echinococcus multilocularis	geminin	0.1044	0.6466	0.6455
Plasmodium vivax	glutathione reductase, putative	0.0043	0.0101	0.746
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0573	0.3469	0.8127
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0097	0.0449	0.8585
Brugia malayi	PAS domain containing protein	0.0044	0.0108	0.0211
Echinococcus multilocularis	transfer RNA-Lys	0.0032	0.0036	0.0006
Mycobacterium tuberculosis	Probable oxidoreductase	0.0108	0.0518	1
Schistosoma mansoni	single-minded	0.0044	0.0108	0.0122
Loa Loa (eye worm)	TAR-binding protein	0.0045	0.0118	0.0208
Loa Loa (eye worm)	glutathione reductase	0.0043	0.0101	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0247	0.0514
Brugia malayi	Nuclear hormone receptor-like 1	0.0573	0.3469	0.8131
Echinococcus multilocularis	ecdysone induced protein 78C	0.0573	0.3469	0.345
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0043	0.0101	0.1464
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0573	0.3469	0.8131
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.027	0.1547	0.3601
Brugia malayi	Nuclear hormone receptor-like 1	0.0303	0.1752	0.4086
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0109	0.0524	0.0769
Trypanosoma cruzi	trypanothione reductase, putative	0.0043	0.0101	0.8036
Brugia malayi	nuclear hormone receptor family member nhr-6	0.027	0.1547	0.3601
Echinococcus granulosus	pikachurin	0.0161	0.0854	0.128
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0125	0.0627	0.0928
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0573	0.3469	0.5344
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Brugia malayi	hypothetical protein	0.0046	0.0122	0.0244
Trypanosoma cruzi	cytochrome P450, putative	0.0047	0.0126	1
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1752	0.407
Schistosoma mansoni	nuclear receptor nhr-48	0.027	0.1547	0.2357
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0142	0.0174
Trypanosoma cruzi	PAB1-binding protein , putative	0.0046	0.0122	0.97
Brugia malayi	glutathione reductase	0.0043	0.0101	0.0195
Schistosoma mansoni	hypothetical protein	0.0125	0.0627	0.0928
Echinococcus granulosus	FTZ F1 alpha	0.0573	0.3469	0.5344
Loa Loa (eye worm)	cytochrome P450 family protein	0.0047	0.0126	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Schistosoma mansoni	transcription factor LCR-F1	0.0109	0.0524	0.0769
Brugia malayi	latrophilin 2 splice variant baaae	0.0271	0.1553	0.3615
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0097	0.0449	0.8585
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0031	0.003	0.2366
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0177	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0573	0.3469	0.5344
Leishmania major	cytochrome p450-like protein	0.0047	0.0126	0.7102
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.027	0.1547	0.44
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0055	0.0177	0.3023
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0097	0.0449	0.8585
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0287	0.1651	0.2519
Mycobacterium ulcerans	putative regulatory protein	0.0032	0.0036	0.0416
Brugia malayi	hypothetical protein	0.0303	0.1752	0.4086
Schistosoma mansoni	laminin gamma-3 chain	0.0161	0.0854	0.128
Brugia malayi	TAR-binding protein	0.0045	0.0118	0.0234
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0573	0.3469	0.8131
Loa Loa (eye worm)	cytochrome P450 family protein	0.0047	0.0126	0.0227
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0573	0.3469	0.5344
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0045	0.0116	0.023
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0045	0.0116	0.0134
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.004	0.1026
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0125	0.0627	0.0928
Mycobacterium tuberculosis	Probable dehydrogenase	0.0097	0.0449	0.8585
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0573	0.3469	0.8127
Echinococcus granulosus	snurportin 1	0.0352	0.2069	0.3168
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Loa Loa (eye worm)	cytochrome P450 family protein	0.0064	0.0234	0.0483
Schistosoma mansoni	nuclear hormone receptor	0.0573	0.3469	0.5344
Brugia malayi	Thioredoxin reductase	0.0043	0.0101	0.0195
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0573	0.3469	0.5344
Brugia malayi	small heat shock protein	0.0698	0.4262	1
Brugia malayi	conserved hypotetical protein	0.027	0.1547	0.3601
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0573	0.3469	0.8127
Onchocerca volvulus	Bile acid receptor homolog	0.0573	0.3469	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0046	0.0122	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0573	0.3469	0.8127
Loa Loa (eye worm)	hypothetical protein	0.0271	0.1553	0.3598
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0118	0.0137
Brugia malayi	ecdysone receptor	0.027	0.1547	0.3601
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0031	0.003	0.2366
Schistosoma mansoni	aryl hydrocarbon receptor	0.0044	0.0108	0.0122
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0161	0.0854	0.1968
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0303	0.1752	0.407
Brugia malayi	EGF-like domain containing protein	0.0161	0.0854	0.1968
Schistosoma mansoni	nuclear hormone receptor	0.027	0.1547	0.2357
Echinococcus granulosus	slit 2 protein	0.0161	0.0854	0.128
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.027	0.1547	0.2357
Schistosoma mansoni	coup transcription factor	0.0573	0.3469	0.5344
Onchocerca volvulus		0.0119	0.0584	0.1597
Schistosoma mansoni	hypothetical protein	0.0109	0.0524	0.0769
Echinococcus multilocularis	GPCR, family 2	0.0125	0.0627	0.0599
Brugia malayi	Latrophilin receptor protein 2	0.0125	0.0627	0.1434
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0287	0.1651	0.3847
Entamoeba histolytica	hypothetical protein	0.0109	0.0524	1
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Brugia malayi	MH2 domain containing protein	0.0108	0.0515	0.1169
Brugia malayi	Fli-1 protein	0.0233	0.1313	0.305
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0764	0.1734
Schistosoma mansoni	nuclear hormone receptor	0.027	0.1547	0.2357
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.027	0.1547	0.3584
Toxoplasma gondii	thioredoxin reductase	0.0043	0.0101	0.4841
Brugia malayi	Cytochrome P450 family protein	0.0064	0.0234	0.0508
Leishmania major	cytochrome p450-like protein	0.0031	0.003	0.168
Brugia malayi	nuclear hormone receptor family member odr-7	0.027	0.1547	0.3601
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0573	0.3469	0.8131
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0573	0.3469	0.8131
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.004	0.001
Brugia malayi	orphan nuclear receptor NR2E1	0.027	0.1547	0.3601
Schistosoma mansoni	RAR-like nuclear receptor	0.0573	0.3469	0.5344
Echinococcus granulosus	Nuclear hormone receptor HR96	0.027	0.1547	0.2357
Plasmodium falciparum	ataxin-2 like protein, putative	0.0046	0.0122	1
Echinococcus granulosus	importin subunit beta 1	0.0033	0.004	0.0015
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0125	0.0627	0.1412
Schistosoma mansoni	retinoic acid receptor RXR	0.0573	0.3469	0.5344
Loa Loa (eye worm)	CYP4Cod1	0.0047	0.0126	0.0227
Brugia malayi	Steroid receptor seven-up type 2	0.0573	0.3469	0.8131
Schistosoma mansoni	hypothetical protein	0.0352	0.2069	0.3168
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0303	0.1752	0.2677
Echinococcus multilocularis	snurportin 1	0.0352	0.2069	0.2045
Brugia malayi	nuclear receptor NHR-67	0.027	0.1547	0.3601
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0573	0.3469	0.345
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0033	0.004	0.0023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0116	0.586
Echinococcus granulosus	GA binding protein alpha chain	0.0077	0.0318	0.0448
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0142	0.0291
Onchocerca volvulus		0.027	0.1547	0.44
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0045	0.0116	0.0087
Trypanosoma brucei	PAB1-binding protein , putative	0.0046	0.0122	0.9608
Schistosoma mansoni	slit	0.0161	0.0854	0.128
Entamoeba histolytica	hypothetical protein	0.0109	0.0524	1
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0077	0.0318	0.0682
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0161	0.0854	0.128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0573	0.3469	0.8127
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0303	0.1752	0.1728
Entamoeba histolytica	hypothetical protein	0.0109	0.0524	1
Leishmania major	hypothetical protein, conserved	0.0046	0.0122	0.6889
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0854	0.1946
Echinococcus granulosus	tar DNA binding protein	0.0045	0.0118	0.0137
Echinococcus granulosus	neurogenic locus notch protein	0.0161	0.0854	0.128
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0108	0.0518	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0573	0.3469	0.8131
Trypanosoma cruzi	cytochrome P450, putative	0.0047	0.0126	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0573	0.3469	0.8131
Brugia malayi	Importin beta-1 subunit	0.0033	0.004	0.005
Schistosoma mansoni	thyroid hormone receptor	0.0573	0.3469	0.5344
Onchocerca volvulus		0.0573	0.3469	1
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0573	0.3469	0.8131
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0116	0.1772
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0108	0.0518	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0303	0.1752	0.4086
Loa Loa (eye worm)	abnormal epIthelia family member	0.0161	0.0854	0.1946
Entamoeba histolytica	hypothetical protein	0.0109	0.0524	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0161	0.0854	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Echinococcus granulosus	nuclear receptor nhr 48	0.027	0.1547	0.2357
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.004	0.1026
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0055	0.0177	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0854	0.1946
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0573	0.3469	0.8131
Echinococcus multilocularis	FTZ F1 alpha	0.0573	0.3469	0.345
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0177	1
Schistosoma mansoni	gabp alpha	0.0077	0.0318	0.0448
Trypanosoma brucei	cytochrome P450, putative	0.0047	0.0126	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.027	0.1547	0.2357
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0118	0.0137
Toxoplasma gondii	aldehyde dehydrogenase	0.0055	0.0177	1
Brugia malayi	bHLH-PAS transcription factor	0.0032	0.0036	0.0041
Schistosoma mansoni	hypothetical protein	0.0125	0.0627	0.0928
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0287	0.1651	0.2519
Brugia malayi	cytochrome P450	0.0031	0.003	0.0026
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.027	0.1547	0.1521
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0573	0.3469	0.8131
Brugia malayi	ecdysteroid receptor	0.0573	0.3469	0.8131
Schistosoma mansoni	hypothetical protein	0.1044	0.6466	1
Brugia malayi	laminin alpha chain	0.0161	0.0854	0.1968
Loa Loa (eye worm)	MH2 domain-containing protein	0.0108	0.0515	0.1146
Onchocerca volvulus		0.027	0.1547	0.44
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0045	0.0118	0.0088
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0042	0.0097	0.0159
Brugia malayi	Cytochrome P450 family protein	0.0047	0.0126	0.0253
Schistosoma mansoni	hypothetical protein	0.1044	0.6466	1
Leishmania major	cytochrome p450-like protein	0.0031	0.003	0.168
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0352	0.2069	0.4817
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0118	0.0137
Brugia malayi	Cytochrome P450 family protein	0.0031	0.003	0.0026
Brugia malayi	photoreceptor-specific nuclear receptor	0.0573	0.3469	0.8131
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.027	0.1547	0.1521
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0045	0.0116	0.6556
Echinococcus multilocularis	GA binding protein alpha chain	0.0077	0.0318	0.0289
Brugia malayi	hypothetical protein	0.0119	0.0584	0.1333
Echinococcus multilocularis	pikachurin	0.0161	0.0854	0.0826
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0573	0.3469	0.345
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0397	0.235	0.5482
Brugia malayi	nuclear hormone receptor	0.0573	0.3469	0.8131
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0097	0.0449	0.8585
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0177	1
Loa Loa (eye worm)	nuclear hormone receptor	0.027	0.1547	0.3584
Schistosoma mansoni	hypothetical protein	0.0049	0.0142	0.0174
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0573	0.3469	0.345
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0287	0.1651	0.3831
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0045	0.0118	0.0208
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0573	0.3469	0.5344
Schistosoma mansoni	cell polarity protein	0.0161	0.0854	0.128
Brugia malayi	hypothetical protein	0.0109	0.0524	0.1192
Loa Loa (eye worm)	hypothetical protein	0.027	0.1547	0.3584
Echinococcus granulosus	survival motor neuron protein 1	0.0241	0.136	0.2066
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.027	0.1547	0.1521
Trypanosoma brucei	trypanothione reductase	0.0043	0.0101	0.7428
Schistosoma mansoni	aldehyde dehydrogenase	0.0055	0.0177	0.0229
Brugia malayi	RNA binding protein	0.0045	0.0118	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0584	0.131
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0397	0.235	0.5494
Schistosoma mansoni	hypothetical protein	0.0271	0.1553	0.2366
Brugia malayi	RNA, U transporter 1	0.0094	0.0426	0.0961
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0125	0.0627	0.0599
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0108	0.0518	1
Plasmodium falciparum	glutathione reductase	0.0043	0.0101	0.746
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0031	0.003	0.168
Brugia malayi	nuclear receptor RXR	0.027	0.1547	0.3601
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0047	0.0126	0.6517
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0573	0.3469	0.8131
Schistosoma mansoni	hypothetical protein	0.0125	0.0627	0.0928
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0573	0.3469	0.345
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0287	0.1651	0.2519
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0573	0.3469	0.8131
Loa Loa (eye worm)	RNA binding protein	0.0045	0.0118	0.0208
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0116	0.586
Loa Loa (eye worm)	hypothetical protein	0.0397	0.235	0.5482
Mycobacterium tuberculosis	Probable reductase	0.0097	0.0449	0.8585
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0573	0.3469	0.345
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0118	0.0137
Onchocerca volvulus		0.0049	0.0142	0.0309
Toxoplasma gondii	LsmAD domain-containing protein	0.0046	0.0122	0.6261
Brugia malayi	hypothetical protein	0.027	0.1547	0.3601
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0573	0.3469	0.8131
Brugia malayi	Nuclear hormone receptor E75	0.027	0.1547	0.3601
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0573	0.3469	0.8131
Brugia malayi	nuclear receptor NHR-88	0.0573	0.3469	0.8131
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1752	0.407
Echinococcus granulosus	Nuclear hormone receptor HR96	0.027	0.1547	0.2357
Brugia malayi	nuclear hormone receptor	0.027	0.1547	0.3601
Loa Loa (eye worm)	DR-78	0.027	0.1547	0.3584
Brugia malayi	nuclear receptor NHR-88	0.027	0.1547	0.3601
Brugia malayi	steroid hormone receptor	0.0573	0.3469	0.8131
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.027	0.1547	0.2357
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0397	0.235	0.5494
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0055	0.0177	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.027	0.1547	0.1521
Loa Loa (eye worm)	transcription factor SMAD2	0.0108	0.0515	0.1146
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0573	0.3469	0.5344
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3469	0.8127
Brugia malayi	Ets-domain containing protein	0.0077	0.0318	0.0706
Loa Loa (eye worm)	nuclear receptor NHR-67	0.027	0.1547	0.3584
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0045	0.0116	0.0134
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.027	0.1547	0.1521
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0303	0.1752	0.2677
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0031	0.003	0.2366
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0573	0.3469	0.345
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.004	0.0669
Schistosoma mansoni	nuclear receptor	0.027	0.1547	0.2357
Loa Loa (eye worm)	steroid hormone receptor	0.0573	0.3469	0.8127
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0122	0.0218
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.027	0.1547	0.2357
Loa Loa (eye worm)	hypothetical protein	0.0241	0.136	0.3142

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3496624

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2070445