Detailed information for compound 2073067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.296 | Formula: C17H24IN3O2
  • H donors: 2 H acceptors: 0 LogP: 2.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CN=C(N1)NCC1(CCCC1)c1ccc2c(c1)OCCO2.I
  • InChi: 1S/C17H23N3O2.HI/c1-2-6-17(5-1,12-20-16-18-7-8-19-16)13-3-4-14-15(11-13)22-10-9-21-14;/h3-4,11H,1-2,5-10,12H2,(H2,18,19,20);1H
  • InChiKey: ISCPMAXHWGMIMQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0119 0.2564 0.2426
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0229 0.0892
Echinococcus granulosus glutamate NMDA receptor subunit 0.0035 0.0565 0.0818
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0452 0.0653
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0017 0.0163 0.0236
Loa Loa (eye worm) glutamate receptor 1 0.0035 0.0565 0.086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0229 0.0348
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit beta 0.0029 0.0435 0.0258
Echinococcus granulosus carboxylesterase 5A 0.0013 0.0055 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0229 0.0348
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0229 0.0348
Toxoplasma gondii protease inhibitor PI2 0.0016 0.0121 0.1462
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0017 0.0163 0.0236
Onchocerca volvulus 0.0023 0.0292 0.1191
Loa Loa (eye worm) hypothetical protein 0.029 0.6572 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0229 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0229 0.0348
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0018 0.0182 0.22
Echinococcus multilocularis glutamate receptor 2 0.0044 0.0777 0.1123
Echinococcus granulosus glutamate receptor 2 0.0026 0.0365 0.0528
Brugia malayi prostaglandin transporter 0.0023 0.0292 0.0445
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0119 0.2564 0.2274
Onchocerca volvulus 0.0023 0.0292 0.1191
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0016 0.0121 0.1462
Loa Loa (eye worm) STAT protein 0.0083 0.1709 0.2601
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0044 0.0777 0.1123
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0452 0.1762
Echinococcus multilocularis Glycosyl transferase, family 35 0.0061 0.1193 0.1725
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.003 0.0469 0.0678
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0029 0.0435 0.3647
Loa Loa (eye worm) dihydrofolate reductase 0.0119 0.2564 0.3901
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0229 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0229 0.0348
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0018 0.0182 0.0988
Loa Loa (eye worm) hypothetical protein 0.0016 0.0121 0.0184
Echinococcus granulosus glycogen phosphorylase 0.0061 0.1193 0.1725
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0435 0.2363
Echinococcus multilocularis tyrosyl tRNA synthetase 0.0066 0.1317 0.1905
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Brugia malayi dihydrofolate reductase family protein 0.0119 0.2564 0.3901
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0229 0.0348
Echinococcus multilocularis tar DNA binding protein 0.0021 0.0236 0.0341
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0445
Echinococcus multilocularis expressed protein 0.0016 0.0121 0.0175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0642 0.0928
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0017 0.0163 0.0236
Brugia malayi methionyl-tRNA synthetase 0.0029 0.0435 0.0662
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0045 0.0807 0.1158
Brugia malayi hypothetical protein 0.003 0.0452 0.0687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0229 0.0348
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0435 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0229 0.0331
Schistosoma mansoni integrin alpha-ps 0.0012 0.0032 0.0126
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.003 0.0469 0.5671
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0229 0.0331
Brugia malayi Integrin alpha pat-2 precursor 0.0051 0.0954 0.1451
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0469 0.2548
Giardia lamblia Methionyl-tRNA synthetase 0.0029 0.0435 0.3647
Entamoeba histolytica glycogen phosphorylase, putative 0.0061 0.1193 1
Entamoeba histolytica hypothetical protein 0.0029 0.0435 0.3647
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Brugia malayi TAR-binding protein 0.0021 0.0236 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0229 0.0348
Schistosoma mansoni thyroid hormone receptor 0.002 0.0229 0.0892
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0018 0.0182 0.22
Loa Loa (eye worm) hypothetical protein 0.0013 0.0055 0.0084
Echinococcus multilocularis ubiquitin specific protease 41 0.003 0.0469 0.0678
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0229 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0021 0.0236 0.0919
Schistosoma mansoni hypothetical protein 0.0047 0.0848 0.3308
Chlamydia trachomatis dihydrofolate reductase 0.0119 0.2564 0.6627
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0018 0.0182 0.1525
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0642 0.0928
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0018 0.0182 0.22
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0469 0.2548
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0229 0.0348
Brugia malayi sodium-independent organic anion transporter family protein 0.0023 0.0292 0.0445
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Onchocerca volvulus Putative organic anion transporter 0.0023 0.0292 0.1191
Loa Loa (eye worm) hypothetical protein 0.0016 0.0121 0.0184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0642 0.0928
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0023 0.0292 0.0423
Echinococcus granulosus integrin alpha ps 0.0023 0.0291 0.042
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Brugia malayi nuclear hormone receptor 0.002 0.0229 0.0348
Brugia malayi Cytochrome P450 family protein 0.0013 0.0054 0.0081
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0018 0.0182 0.0709
Loa Loa (eye worm) hypothetical protein 0.0016 0.0121 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0642 0.2503
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0229 0.0348
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0229 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0435 0.2363
Echinococcus granulosus survival motor neuron protein 1 0.029 0.6572 0.9504
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Entamoeba histolytica glycogen phosphorylase, putative 0.0026 0.0375 0.3141
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0044 0.0777 0.1123
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0026 0.0375 0.0196
Toxoplasma gondii methionyl-tRNA synthetase 0.0029 0.0435 0.5261
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0046 0.0827 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0229 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0435 0.2363
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0229 0.0348
Leishmania major tyrosyl-tRNA synthetase, putative 0.0037 0.0634 0.7667
Entamoeba histolytica hypothetical protein 0.003 0.0452 0.3787
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0016 0.0121 0.0184
Echinococcus multilocularis integrin alpha ps 0.0023 0.0291 0.042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0415 0.0631
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0469 0.5671
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.003 0.0469 0.0714
Brugia malayi nuclear receptor RXR 0.0011 0.0004 0.0006
Echinococcus multilocularis dihydrofolate reductase 0.0119 0.2564 0.3707
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0059 0.1143 0.1739
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0452 0.0653
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.003 0.0469 0.1829
Echinococcus granulosus integrin alpha ps 0.0011 0.001 0.0014
Echinococcus multilocularis survival motor neuron protein 1 0.029 0.6572 0.9504
Loa Loa (eye worm) glutaminase 2 0.0089 0.184 0.2801
Loa Loa (eye worm) ATP-citrate synthase 0.0041 0.0728 0.1107
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0469 0.2548
Brugia malayi SPARC precursor 0.0016 0.0121 0.0184
Toxoplasma gondii transporter, major facilitator family protein 0.0023 0.0292 0.3537
Echinococcus multilocularis NMDA receptor 0.0017 0.0163 0.0236
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0017 0.0163 0.0236
Trichomonas vaginalis glycogen phosphorylase, putative 0.0061 0.1193 0.648
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0038 0.0642 0.0976
Brugia malayi STAT protein, DNA binding domain containing protein 0.0083 0.1709 0.2601
Schistosoma mansoni cellular tumor antigen P53 0.0045 0.08 0.3121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0229 0.0331
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0037 0.0634 0.3444
Brugia malayi sodium-independent organic anion transporter family protein 0.0023 0.0292 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0229 0.0348
Echinococcus multilocularis integrin alpha 3 0.0039 0.0673 0.0974
Schistosoma mansoni tar DNA-binding protein 0.0021 0.0236 0.0919
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0045 0.0807 0.0449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0642 0.2503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0229 0.0348
Echinococcus granulosus Solute carrier organic anion transporter family 0.0023 0.0292 0.0423
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0018 0.0182 0.0709
Echinococcus multilocularis nmda type glutamate receptor 0.0062 0.1219 0.1763
Echinococcus multilocularis integrin alpha ps 0.0011 0.001 0.0014
Echinococcus granulosus follistatin 0.0016 0.0121 0.0175
Schistosoma mansoni nuclear hormone receptor 0.002 0.0229 0.0892
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0046 0.0827 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0006
Schistosoma mansoni thyroid hormone receptor 0.002 0.0229 0.0892
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.003 0.0469 0.0678
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0016 0.0121 0.1462
Schistosoma mansoni follistatin 0.0016 0.0121 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0229 0.0348
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0229 0.0331
Chlamydia trachomatis glutamine binding protein 0.0045 0.0807 0.1158
Echinococcus granulosus acetylcholinesterase 0.0013 0.0055 0.008
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0018 0.0182 0.0277
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0242 0.2928
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0044 0.0777 0.1123
Schistosoma mansoni integrin alpha 0.0051 0.0954 0.3721
Loa Loa (eye worm) TAR-binding protein 0.0021 0.0236 0.0359
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0004 0.0015
Echinococcus multilocularis glycogen phosphorylase 0.0061 0.1193 0.1725
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0046 0.0827 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0229 0.0331
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0016 0.0121 0.1462
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0229 0.0348
Brugia malayi Carboxylesterase family protein 0.0013 0.0055 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0445
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0565 0.2206
Leishmania major tyrosyl or methionyl-tRNA synthetase-like protein 0.0029 0.0435 0.5261
Brugia malayi RNA binding protein 0.0021 0.0236 0.0359
Echinococcus granulosus tar DNA binding protein 0.0021 0.0236 0.0341
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Echinococcus multilocularis acetylcholinesterase 0.0013 0.0055 0.008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0229 0.0892
Loa Loa (eye worm) acetylcholinesterase 1 0.0013 0.0055 0.0084
Echinococcus granulosus integrin alpha 3 0.0039 0.0673 0.0974
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0229 0.0892
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, beta chain PheT 0.0029 0.0435 0.0063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0229 0.0331
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0044 0.0777 0.1123
Onchocerca volvulus Glycogen phosphorylase homolog 0.0061 0.1193 0.7438
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.0029 0.0435 0.5261
Brugia malayi hypothetical protein 0.0021 0.0242 0.0368
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0045 0.0807 0.0637
Echinococcus multilocularis tumor protein p63 0.0304 0.6915 1
Echinococcus multilocularis follistatin 0.0016 0.0121 0.0175
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0242 0.2928
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0229 0.0892
Onchocerca volvulus 0.0023 0.0292 0.1191
Loa Loa (eye worm) integrin alpha pat-2 0.0079 0.1605 0.2442
Schistosoma mansoni dihydrofolate reductase 0.0119 0.2564 1
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0018 0.0182 0.22
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0642 0.2503
Giardia lamblia Glycogen phosphorylase 0.0061 0.1193 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0044 0.0777 0.1123
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0229 0.0331
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0242 0.2928
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0023 0.0292 0.0423
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0565 0.2206
Plasmodium vivax tyrosine--tRNA ligase, putative 0.0037 0.0634 0.7667
Loa Loa (eye worm) RNA binding protein 0.0021 0.0236 0.0359
Plasmodium vivax methionine-tRNA ligase, putative 0.0029 0.0435 0.5261
Trypanosoma cruzi tyrosyl-tRNA synthetase, putative 0.0037 0.0634 0.7667
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0121 0.0184
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0018 0.0182 0.1525
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0229 0.0892
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0039 0.0661 0.1006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0469 0.5671
Echinococcus multilocularis acetylcholinesterase 0.0013 0.0055 0.008
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0062 0.1219 0.1763
Brugia malayi Carboxylesterase family protein 0.0013 0.0055 0.0084
Loa Loa (eye worm) hypothetical protein 0.004 0.0696 0.1058
Giardia lamblia Tyrosyl-tRNA synthetase 0.0037 0.0634 0.5316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0642 0.0928
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0242 0.2928
Schistosoma mansoni glycogen phosphorylase 0.0061 0.1193 0.4652
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0435 0.5261
Trichomonas vaginalis glycogen phosphorylase, putative 0.0061 0.1193 0.648
Schistosoma mansoni integrin alpha-ps 0.0023 0.0291 0.1134
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.003 0.0469 0.0678
Loa Loa (eye worm) hypothetical protein 0.0016 0.0121 0.0184
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0165 0.3647 1
Brugia malayi hypothetical protein 0.0023 0.0292 0.0445
Brugia malayi secreted modular calcium-binding protein 1 0.0016 0.0121 0.0184
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0017 0.0163 0.0236
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0045 0.0807 0.1158
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0029 0.0435 0.5261
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.0037 0.0634 0.7667
Schistosoma mansoni methionyl-tRNA synthetase 0.0029 0.0435 0.1697
Entamoeba histolytica glycogen phosphorylase, putative 0.0026 0.0375 0.3141
Toxoplasma gondii ATP-citrate lyase, putative 0.0041 0.0728 0.88
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0046 0.0827 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0229 0.0348
Echinococcus granulosus FTZ F1 alpha 0.002 0.0229 0.0331
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0121 0.0184
Schistosoma mansoni organic anion transporter 0.0023 0.0292 0.1141
Schistosoma mansoni tyrosyl-tRNA synthetase 0.0066 0.1317 0.5138
Onchocerca volvulus Putative organic anion transporter 0.0023 0.0292 0.1191
Brugia malayi Pre-SET motif family protein 0.0068 0.1342 0.2042
Brugia malayi hypothetical protein 0.0013 0.0068 0.0104
Brugia malayi ATP-citrate synthase 0.0041 0.0728 0.1107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0445
Loa Loa (eye worm) hypothetical protein 0.0013 0.0055 0.0084
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0029 0.0435 0.5261
Mycobacterium ulcerans glutaminase 0.0089 0.184 0.1689
Echinococcus granulosus acetylcholinesterase 0.0013 0.0055 0.008
Entamoeba histolytica hypothetical protein 0.003 0.0452 0.3787
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.003 0.0469 0.3932
Loa Loa (eye worm) hypothetical protein 0.0018 0.0182 0.0277
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0229 0.0331
Echinococcus multilocularis glutamate receptor 2 0.0026 0.0365 0.0528
Onchocerca volvulus 0.0077 0.1562 1
Trypanosoma brucei tyrosyl/methionyl-tRNA synthetase, putative 0.0029 0.0435 0.5261
Onchocerca volvulus 0.0023 0.0292 0.1191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0229 0.0331
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0068 0.1342 0.2042
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0046 0.0827 1
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.0165 0.3647 1
Schistosoma mansoni agrin 0.0016 0.0121 0.0472
Brugia malayi hypothetical protein 0.0011 0.0004 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0242 0.2928
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0049
Schistosoma mansoni organic anion transporter 0.0023 0.0292 0.1141
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0242 0.2928
Entamoeba histolytica tyrosyl-tRNA synthetase, putative 0.0037 0.0634 0.5316
Brugia malayi steroid hormone receptor 0.002 0.0229 0.0348
Brugia malayi ecdysteroid receptor 0.002 0.0229 0.0348
Brugia malayi sodium-independent organic anion transporter family protein 0.0023 0.0292 0.0445
Plasmodium falciparum tyrosine--tRNA ligase 0.0037 0.0634 0.7667
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Schistosoma mansoni coup transcription factor 0.002 0.0229 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0435 0.2363
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0018 0.0182 0.0263
Onchocerca volvulus 0.0045 0.08 0.4714
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0004 0.0006
Loa Loa (eye worm) agrin synaptic family protein 0.0016 0.0121 0.0184
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0661 0.1006
Loa Loa (eye worm) glutamate receptor 2 0.0035 0.0565 0.086
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0054 0.0081
Echinococcus multilocularis agrin 0.0016 0.0121 0.0175
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0021 0.0236 0.0359
Onchocerca volvulus 0.0018 0.0182 0.0423
Brugia malayi nuclear receptor NHR-88 0.002 0.0229 0.0348
Echinococcus multilocularis integrin alpha ps 0.0023 0.0291 0.042
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0229 0.0749
Trichomonas vaginalis methionyl-tRNA synthetase, putative 0.0029 0.0435 0.2363
Schistosoma mansoni tar DNA-binding protein 0.0021 0.0236 0.0919
Schistosoma mansoni hypothetical protein 0.003 0.0452 0.1762
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0038 0.0642 0.0976
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0018 0.0182 0.0263
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0018 0.0182 0.22
Trichomonas vaginalis set domain proteins, putative 0.0077 0.1562 0.8485
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0044 0.0777 0.1123
Brugia malayi Glutamate receptor 2 precursor 0.0035 0.0565 0.086
Brugia malayi RNA recognition motif domain containing protein 0.0021 0.0236 0.0359
Loa Loa (eye worm) carboxylesterase 0.0013 0.0055 0.0084
Brugia malayi Glutamate receptor 1 precursor 0.0035 0.0565 0.086
Onchocerca volvulus 0.0023 0.0292 0.1191
Loa Loa (eye worm) hypothetical protein 0.0045 0.08 0.1218
Brugia malayi hypothetical protein 0.0023 0.0292 0.0445
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0229 0.0892
Entamoeba histolytica glycogen phosphorylase, putative 0.0061 0.1193 1
Brugia malayi glutaminase DH11.1 0.0089 0.184 0.2801
Leishmania major hypothetical protein 0.0029 0.0435 0.5261
Leishmania major hypothetical protein, conserved 0.0029 0.0435 0.5261
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0229 0.0348
Toxoplasma gondii tRNA binding domain-containing protein 0.0029 0.0435 0.5261
Brugia malayi carbohydrate phosphorylase 0.0061 0.1193 0.1815
Schistosoma mansoni glutamate receptor NMDA 0.0044 0.0777 0.3029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0229 0.0348
Schistosoma mansoni survival motor neuron protein 0.0059 0.1143 0.4457
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0229 0.0348
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Schistosoma mansoni glutamate receptor NMDA 0.0035 0.0565 0.2206
Leishmania major hypothetical protein, conserved 0.0021 0.0242 0.2928
Trichomonas vaginalis glutaminase, putative 0.0089 0.184 1
Brugia malayi hypothetical protein 0.0011 0.0004 0.0006
Entamoeba histolytica hypothetical protein 0.003 0.0452 0.3787
Echinococcus granulosus Glycosyl transferase family 35 0.0061 0.1193 0.1725
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0229 0.0749
Echinococcus granulosus agrin 0.0016 0.0121 0.0175
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0565 0.2206
Schistosoma mansoni glycogen phosphorylase 0.0061 0.1193 0.4652
Echinococcus granulosus glutamate receptor 2 0.0044 0.0777 0.1123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0229 0.0348
Entamoeba histolytica glycogenphosphorylase, putative 0.0026 0.0375 0.3141
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0229 0.0331
Schistosoma mansoni hypothetical protein 0.0059 0.1143 0.4457
Echinococcus granulosus ubiquitin specific protease 41 0.003 0.0469 0.0678
Echinococcus granulosus tumor protein p63 0.0304 0.6915 1
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0565 0.2206
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0435 0.5261
Schistosoma mansoni hypothetical protein 0.0017 0.0163 0.0637
Echinococcus granulosus aminoacyl tRNA synthase complex interacting 0.0029 0.0435 0.0629
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0045 0.0807 0.1158
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0029 0.0435 0.0662
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0018 0.0182 0.22
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0229 0.0348
Onchocerca volvulus 0.0059 0.1143 0.7092
Entamoeba histolytica hypothetical protein 0.0029 0.0435 0.3647
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0469 0.5671
Trypanosoma cruzi MFS transporter, putative 0.0023 0.0292 0.3537
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0242 0.2928
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0229 0.0892
Echinococcus granulosus tyrosyl tRNA synthetase 0.0066 0.1317 0.1905
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0445
Echinococcus multilocularis carboxylesterase 5A 0.0013 0.0055 0.008
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.003 0.0469 0.0678
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0013 0.0055 0.0215
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0229 0.0749
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0039
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0435 1 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0017 0.0163 0.0236
Brugia malayi hypothetical protein 0.029 0.6572 1
Onchocerca volvulus 0.002 0.0229 0.0749
Loa Loa (eye worm) hypothetical protein 0.0021 0.0242 0.0368
Echinococcus granulosus glycogen phosphorylase 0.0061 0.1193 0.1725
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0035 0.0565 0.0818
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0121 0.0184
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0006
Echinococcus granulosus dihydrofolate reductase 0.0119 0.2564 0.3707
Schistosoma mansoni ATP-binding cassette transporter 0.0035 0.0565 0.2206
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0565 0.2206
Echinococcus granulosus nmda type glutamate receptor 0.0062 0.1219 0.1763
Echinococcus granulosus glutamate receptor subunit protein glur 0.0017 0.0163 0.0236
Chlamydia trachomatis glycogen phosphorylase 0.0061 0.1193 0.2358
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0023 0.0292 0.0423
Schistosoma mansoni tar DNA-binding protein 0.0021 0.0236 0.0919
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0435 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0229 0.0892
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0023 0.0292 0.0445
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0229 0.0331
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0016 0.0121 0.1462
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0229 0.0892
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0565 0.0818
Echinococcus multilocularis glycogen phosphorylase 0.0061 0.1193 0.1725
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0005
Entamoeba histolytica hypothetical protein 0.003 0.0452 0.3787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0229 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0021 0.0236 0.0919
Loa Loa (eye worm) glycogen phosphorylase 0.0061 0.1193 0.1815
Schistosoma mansoni ATP-citrate synthase 0.0035 0.0578 0.2256
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.003 0.0469 0.1829
Schistosoma mansoni glutaminase 0.0089 0.184 0.7179
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0046 0.0827 1
Onchocerca volvulus Putative organic anion transporter 0.0023 0.0292 0.1191
Toxoplasma gondii tRNA synthetases class I family protein 0.0037 0.0634 0.7667
Loa Loa (eye worm) hypothetical protein 0.003 0.0469 0.0714
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0445
Loa Loa (eye worm) hypothetical protein 0.002 0.0229 0.0348
Loa Loa (eye worm) glutaminase 0.0089 0.184 0.2801
Plasmodium falciparum tRNA import protein tRIP 0.0029 0.0435 0.5261
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0044 0.0777 0.1123
Echinococcus multilocularis aminoacyl tRNA synthase complex interacting 0.0029 0.0435 0.0629
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0044 0.0777 0.1123
Brugia malayi Dihydrofolate reductase 0.0119 0.2564 0.3901
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0018 0.0182 0.22
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0121 0.0184
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0229 0.0331
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.003 0.0469 0.3932
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0229 0.0348
Loa Loa (eye worm) hypothetical protein 0.0023 0.0292 0.0445
Schistosoma mansoni glycogen phosphorylase 0.0026 0.0375 0.1461
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0229 0.0331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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