TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.645 | Formula: C22H33N3O4S2
H donors: 2 H acceptors: 2 LogP: 2.16 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: SC[C@@H](/C=C/CN1C[C@H](C[C@@H]1C(=O)N[C@H](C(=O)OC)CCSC)Oc1ccccc1)N
InChi: 1S/C22H33N3O4S2/c1-28-22(27)19(10-12-31-2)24-21(26)20-13-18(29-17-8-4-3-5-9-17)14-25(20)11-6-7-16(23)15-30/h3-9,16,18-20,30H,10-15,23H2,1-2H3,(H,24,26)/b7-6+/t16-,18+,19+,20-/m1/s1
InChiKey: DAKLZKDSHKWINM-RTEFKXEASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	muscleblind protein	0.0087	0.1999	0.1999
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0058	0.0058
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1156	0.2962
Schistosoma mansoni	BC026374 protein (S09 family)	0.0066	0.1445	0.1445
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.012	0.2858	0.88
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1445	0.1445
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0133	0.321	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0066	0.1445	0.1445
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0021	0.0258	0.0258
Loa Loa (eye worm)	integrin alpha pat-2	0.0264	0.6649	0.6649
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1156	0.2962
Mycobacterium tuberculosis	Probable esterase LipL	0.0021	0.0258	0.056
Loa Loa (eye worm)	hypothetical protein	0.0392	1	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0032	0.0545	0.0828
Onchocerca volvulus		0.0066	0.1445	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0011	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0021	0.0258	0.0258
Brugia malayi	MH2 domain containing protein	0.007	0.1538	0.1538
Loa Loa (eye worm)	glutaminase	0.016	0.3902	0.3902
Brugia malayi	Integrin alpha pat-2 precursor	0.0215	0.5341	0.5341
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0066	0.1445	0.4321
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0021	0.0258	0.0462
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0005	0.0005
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0258	0.0316
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.012	0.2858	0.88
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0021	0.0258	0.056
Mycobacterium tuberculosis	Conserved protein	0.0021	0.0258	0.056
Mycobacterium tuberculosis	Probable lipase LipD	0.0021	0.0258	0.056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0295	0.0295
Toxoplasma gondii	thioredoxin reductase	0.0053	0.1088	0.7037
Schistosoma mansoni	hypothetical protein	0.0012	0.0022	0.0022
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0015	0.0104	0.0104
Entamoeba histolytica	hypothetical protein	0.0021	0.0258	0.2232
Schistosoma mansoni	integrin alpha-ps	0.005	0.1021	0.1021
Echinococcus multilocularis	expressed protein	0.0218	0.5436	0.5436
Loa Loa (eye worm)	glutathione reductase	0.0053	0.1088	0.1088
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1156	0.2962
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.2971	0.517
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0032	0.0545	0.0828
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0021	0.0258	0.056
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1445	0.1445
Entamoeba histolytica	hypothetical protein	0.0021	0.0258	0.2232
Brugia malayi	hypothetical protein	0.0021	0.0258	0.0258
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0018	0.0185	0.0326
Echinococcus multilocularis	integrin alpha 3	0.0164	0.4026	0.4026
Echinococcus multilocularis	zinc finger protein	0.0013	0.0058	0.0058
Schistosoma mansoni	acetylcholinesterase	0.0066	0.1445	0.1445
Mycobacterium ulcerans	glutaminase	0.016	0.3902	1
Echinococcus granulosus	BC026374 protein S09 family	0.0066	0.1445	0.1445
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0018	0.0185	0.0184
Trypanosoma brucei	hypothetical protein, conserved	0.0021	0.0258	0.0135
Leishmania major	trypanothione reductase	0.0053	0.1088	0.18
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1445	0.1445
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.1096	0.1096
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0021	0.0258	0.0258
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0055	0.1156	0.1921
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0021	0.0258	0.0258
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0021	0.0257	0.0257
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0066	0.1445	0.1445
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0066	0.1445	0.1445
Schistosoma mansoni	integrin alpha	0.0215	0.5341	0.5341
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0018	0.0185	0.0269
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.1088	0.18
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0227	0.5671	1
Schistosoma mansoni	gliotactin	0.0066	0.1445	0.1445
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.012	0.2858	0.88
Mycobacterium ulcerans	lipase LipD	0.0021	0.0258	0.0462
Brugia malayi	Carboxylesterase family protein	0.0066	0.1445	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0168	0.413	0.413
Echinococcus granulosus	geminin	0.0203	0.504	0.504
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0258	0.0258
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0185	0.0184
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0058	0.0058
Toxoplasma gondii	hypothetical protein	0.0037	0.0668	0.3766
Trypanosoma cruzi	trypanothione reductase, putative	0.0018	0.0185	0.0184
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Giardia lamblia	Kinase, PLK	0.0055	0.1156	1
Echinococcus multilocularis	acetylcholinesterase	0.0392	1	1
Brugia malayi	Carboxylesterase family protein	0.0066	0.1445	0.1445
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0066	0.1445	0.4321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1445	0.1445
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.1156	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0258	0.0258
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1156	0.2962
Brugia malayi	Muscleblind-like protein	0.0087	0.1999	0.1999
Loa Loa (eye worm)	transcription factor SMAD2	0.007	0.1538	0.1538
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1156	0.2962
Schistosoma mansoni	hypothetical protein	0.0203	0.504	0.504
Entamoeba histolytica	hypothetical protein	0.0021	0.0258	0.2232
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0011	0.0005	0.0005
Mycobacterium tuberculosis	Conserved hypothetical protein	0.012	0.2848	0.8767
Trypanosoma brucei	polo-like protein kinase	0.0055	0.1156	0.177
Echinococcus multilocularis	acetylcholinesterase	0.0392	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0027	0.0424	0.1085
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0674	0.0674
Loa Loa (eye worm)	MH2 domain-containing protein	0.007	0.1538	0.1538
Echinococcus granulosus	neuroligin	0.0066	0.1445	0.1445
Loa Loa (eye worm)	carboxylesterase	0.0066	0.1445	0.1445
Echinococcus multilocularis	para nitrobenzyl esterase	0.0066	0.1445	0.1445
Brugia malayi	Thioredoxin reductase	0.0053	0.1088	0.1088
Treponema pallidum	NADH oxidase	0.0018	0.0185	0.5
Echinococcus multilocularis	muscleblind protein	0.0087	0.1999	0.1999
Schistosoma mansoni	integrin alpha-ps	0.0096	0.2232	0.2232
Brugia malayi	Carboxylesterase family protein	0.0066	0.1445	0.1445
Echinococcus granulosus	acetylcholinesterase	0.0392	1	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0055	0.1156	1
Schistosoma mansoni	bromodomain containing protein	0.0039	0.0729	0.0729
Echinococcus multilocularis	carboxylesterase 5A	0.0392	1	1
Echinococcus multilocularis	integrin alpha ps	0.0096	0.2232	0.2232
Trichomonas vaginalis	CAMK family protein kinase	0.0027	0.0424	0.1085
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1445	0.1445
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0021	0.0258	0.056
Onchocerca volvulus		0.0066	0.1445	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.2225	0.2225
Echinococcus granulosus	zinc finger protein	0.0013	0.0058	0.0058
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0018	0.0185	0.0185
Brugia malayi	beta-lactamase family protein	0.0021	0.0258	0.0258
Leishmania major	mitochondrial DNA polymerase beta	0.0227	0.5671	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0066	0.1445	0.3569
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0067	0.1468	1
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0018	0.0185	0.0185
Trichomonas vaginalis	glutaminase, putative	0.016	0.3902	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0066	0.1445	0.1445
Trichomonas vaginalis	mercuric reductase, putative	0.0018	0.0185	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1445	0.1445
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0134	0.3237	1
Mycobacterium tuberculosis	Probable hydrolase	0.0021	0.0258	0.056
Mycobacterium ulcerans	beta-lactamase	0.0021	0.0258	0.0462
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.012	0.2858	0.88
Schistosoma mansoni	hypothetical protein	0.0046	0.0917	0.0917
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0617	0.0617
Plasmodium falciparum	glutathione reductase	0.0053	0.1088	1
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0005	0.0005
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.1088	0.1088
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1999	0.1999
Echinococcus granulosus	acetylcholinesterase	0.0392	1	1
Schistosoma mansoni	zinc finger protein	0.0013	0.0058	0.0058
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0011	0.0005	0.0005
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0021	0.0258	0.0258
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1638	0.1638
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0258	0.0817
Trichomonas vaginalis	penicillin-binding protein, putative	0.0021	0.0258	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0118	0.2815	0.2815
Schistosoma mansoni	cpg binding protein	0.0038	0.0698	0.0698
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0032	0.0545	0.0656
Schistosoma mansoni	glutaminase	0.016	0.3902	0.3902
Trypanosoma brucei	RNA helicase, putative	0.0054	0.1126	0.1716
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0055	0.1156	0.1156
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0617	0.0617
Trichomonas vaginalis	spcc417.12 protein, putative	0.0066	0.1445	0.3703
Onchocerca volvulus		0.0066	0.1445	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0674	0.0674
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0015	0.0104	0.0104
Loa Loa (eye worm)	carboxylesterase	0.0066	0.1445	0.1445
Plasmodium falciparum	thioredoxin reductase	0.0053	0.1088	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Schistosoma mansoni	cpg binding protein	0.0035	0.0617	0.0617
Echinococcus granulosus	para nitrobenzyl esterase	0.0066	0.1445	0.1445
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0185	0.0185
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0018	0.0185	0.0184
Echinococcus multilocularis	muscleblind protein 1	0.0087	0.1999	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0258	0.0258
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0227	0.5671	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0021	0.0257	0.0257
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.2971	0.517
Brugia malayi	serine/threonine-protein kinase plk-2	0.0055	0.1156	0.1156
Trichomonas vaginalis	esterase, putative	0.0021	0.0258	0.0662
Echinococcus granulosus	integrin alpha ps	0.0096	0.2232	0.2232
Echinococcus granulosus	integrin alpha 3	0.0164	0.4026	0.4026
Mycobacterium tuberculosis	Probable lipase LipE	0.0021	0.0258	0.056
Echinococcus granulosus	expressed protein	0.0218	0.5436	0.5436
Echinococcus multilocularis	neuroligin	0.0066	0.1445	0.1445
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0066	0.1445	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1999	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0917	0.0917
Onchocerca volvulus		0.0066	0.1445	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0055	0.1156	0.1921
Brugia malayi	glutaminase DH11.1	0.016	0.3902	0.3902
Loa Loa (eye worm)	beta-lactamase	0.0021	0.0258	0.0258
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0018	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.005	0.1021	0.1021
Brugia malayi	Carboxylesterase family protein	0.0392	1	1
Echinococcus granulosus	carboxylesterase 5A	0.0392	1	1
Onchocerca volvulus		0.0035	0.0617	0.3019
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.1088	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.012	0.2858	0.88
Brugia malayi	hypothetical protein	0.0066	0.1445	0.1445
Echinococcus granulosus	cpg binding protein	0.0038	0.0698	0.0698
Mycobacterium tuberculosis	Probable reductase	0.012	0.2858	0.88
Schistosoma mansoni	transcription factor LCR-F1	0.0021	0.0258	0.0258
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0133	0.321	0.9915
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0412	0.0412
Loa Loa (eye worm)	acetylcholinesterase 1	0.0392	1	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.1088	0.3188
Toxoplasma gondii	ABC1 family protein	0.0021	0.0258	0.0575
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0014	0.0082	0.0082
Loa Loa (eye worm)	PHD-finger family protein	0.0012	0.0022	0.0022
Trypanosoma brucei	trypanothione reductase	0.0053	0.1088	0.1646
Trichomonas vaginalis	D-aminoacylase, putative	0.0021	0.0258	0.0662
Mycobacterium tuberculosis	Probable oxidoreductase	0.0133	0.321	0.9915
Echinococcus multilocularis	integrin alpha ps	0.0046	0.0917	0.0917
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0018	0.0185	0.0269
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0107	0.2529	0.4378
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0066	0.1445	0.3703
Schistosoma mansoni	hypothetical protein	0.0054	0.1126	0.1126
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1156	0.2962
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0107	0.2529	0.4378
Echinococcus granulosus	beta LACTamase domain containing family member	0.0021	0.0258	0.0258
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0021	0.0258	0.0258
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0107	0.2529	0.4273
Entamoeba histolytica	hypothetical protein	0.0021	0.0258	0.2232
Trichomonas vaginalis	D-aminoacylase, putative	0.0021	0.0258	0.0662
Leishmania major	hypothetical protein, conserved	0.0021	0.0258	0.0316
Echinococcus granulosus	fetal alzheimer antigen falz	0.0015	0.0104	0.0104
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0133	0.321	0.9915
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0021	0.0258	0.0258
Brugia malayi	beta-lactamase family protein	0.0021	0.0258	0.0258
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0066	0.1445	0.1445
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0018	0.0185	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0124	0.2971	0.5079
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0055	0.1156	0.1156
Schistosoma mansoni	hypothetical protein	0.0203	0.504	0.504
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0066	0.1445	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0791	0.0791
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0011	0.0005	0.0005
Plasmodium vivax	glutathione reductase, putative	0.0053	0.1088	1
Echinococcus multilocularis	integrin alpha ps	0.0096	0.2232	0.2232
Loa Loa (eye worm)	carboxylesterase	0.0392	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0021	0.0258	0.0662
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0014	0.0082	0.021
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1445	0.1445
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0392	1	1
Leishmania major	hypothetical protein, conserved	0.0124	0.2971	0.517
Mycobacterium ulcerans	hypothetical protein	0.012	0.2848	0.7241
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0258	0.0462
Mycobacterium tuberculosis	Conserved protein	0.0021	0.0258	0.056
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0018	0.0185	0.0269
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0096	0.2225	0.2225
Echinococcus granulosus	integrin alpha ps	0.0046	0.0917	0.0917
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0055	0.1156	0.1156
Trichomonas vaginalis	penicillin-binding protein, putative	0.0021	0.0258	0.0662
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1156	0.2962
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.1096	0.1096
Brugia malayi	glutathione reductase	0.0053	0.1088	0.1088
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0039	0.0728	0.1156
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0185	0.0184
Schistosoma mansoni	cpg binding protein	0.0038	0.0698	0.0698
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0032	0.0545	0.0828
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0258	0.0316
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0227	0.5671	1
Trichomonas vaginalis	glutathione reductase, putative	0.0018	0.0185	0.0473
Trypanosoma cruzi	polo-like protein kinase, putative	0.0055	0.1156	0.1921
Echinococcus granulosus	citrate lyase subunit beta protein	0.0014	0.0082	0.0082
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0185	0.0184
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0055	0.1156	0.7562
Echinococcus multilocularis	cpg binding protein	0.0038	0.0698	0.0698
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0066	0.1445	0.4321
Brugia malayi	Carboxylesterase family protein	0.0066	0.1445	0.1445
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0021	0.0258	0.0258
Schistosoma mansoni	kinase	0.0028	0.0443	0.0443
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0005	0.0005
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0185	0.5
Brugia malayi	Bromodomain containing protein	0.0046	0.0909	0.0909
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.012	0.2858	0.8808
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0331	0.0331
Brugia malayi	Bromodomain containing protein	0.0022	0.0294	0.0294
Mycobacterium ulcerans	esterase/lipase LipP	0.0021	0.0258	0.0462
Brugia malayi	PHD-finger family protein	0.0017	0.014	0.014
Brugia malayi	beta-lactamase	0.0021	0.0258	0.0258
Onchocerca volvulus		0.0066	0.1445	1
Echinococcus multilocularis	geminin	0.0203	0.504	0.504
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0185	0.5
Loa Loa (eye worm)	glutaminase 2	0.016	0.3902	0.3902
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0258	0.0258
Mycobacterium tuberculosis	Conserved protein	0.0021	0.0258	0.056
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0011	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0392	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3545945

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2074063